abstract: Posttransplant @entity1017 is common after orthotopic liver transplantation. We sought to determine the extent of @entity1017 at 5 years after transplantation in @entity1 with @entity1561 ( @entity1561 ) @entity82 versus @entity1 with other types of @entity82 ( @entity1561 ). We studied 126 liver transplants performed between 2005 and 2007 at Saint Luc Hospital, University of Montreal. Seventeen of the 126 @entity1 (13.5%) had @entity1561 @entity82 . Ascites volume was difficult to assess, so we used the body mass index (BMI) at 3 months as the reference BMI. All @entity1 gained weight after transplantation, but BMI increased significantly more and earlier among the @entity1561 @entity1 [4.8 versus 1.5 kg/m(2) at 1 year (P   =   0.001), 5.0 versus 2.3 kg/m(2) at 2 years (P   =   0.01), and 5.6 versus 2.6 kg/m(2) at 5 years (P   =   0.009)] in comparison with @entity1561 @entity1 in unadjusted analyses. The greatest BMI increase over time was investigated with univariate and multivariate logistic regression analyses. The BMI increase was divided into tertiles for each period of time observed. The greatest BMI increase over time was defined as the top tertile of BMI increase. After adjustments for potential confounders (ie, total @entity165 , @entity6 , and length of hospital stay), @entity1561 was no longer associated with a risk of a greater BMI increase [odds ratio (OR)   =   3.73 at 1 year (P   =   0.11), OR   =   2.15 at 2 years (P   =   0.34), and OR   =   2.87 at 5 years (P   =   0.30)]. These findings suggest the need for multidisciplinary, early, and close weight monitoring for all @entity1 . All @entity1 could benefit from pretransplant counseling regarding @entity1017 and its consequences.

title: @entity1017 after orthotopic liver transplantation: is @entity1561 @entity82 a risk factor for greater XXXX ?

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity1561 :: ('MESH:D065626', 'Disease') :: ['NAFLD', 'nonalcoholic fatty liver disease', 'non-NAFLD']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1017 :: (MESH:D015430,Disease) :: ['weight gain']


abstract: BACKGROUND AND PURPOSE: The aim of this pilot study was to assess @entity71 in @entity1 with @entity510 using the test of variables of attention (TOVA). This is a computer-based continuous performance test providing objective measures of attention. We also compared the TOVA results with the attention and concentration domains of Montgomery   sberg Depression Rating Scale and Montreal cognitive assessment, 2 examiner-administrated neuropsychological instruments. METHODS: Nineteen @entity1 with moderate to good recovery (Glasgow outcome scale, 4-5) were assessed using the TOVA, Montgomery   sberg Depression Rating Scale, and Montreal cognitive assessment. The measurements were done when the @entity1 visited the hospital for a routine magnetic resonance imaging control of the @entity439 . RESULTS: TOVA performance was pathological in 58%. The dominating pattern was a worsening of performance in the second half of the test, commonly a failing to react to correct stimuli. We found no correlation between TOVA and the performance in concentration and attention domains of Montgomery   sberg Depression Rating Scale and Montreal cognitive assessment. CONCLUSIONS: @entity71 , measured by the TOVA, were common after @entity510 . This should be further studied to improve outcome.

title: @entity71 After XXXX Measured Using the Test of Variables of Attention.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['Attention deficits', 'attention deficits']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'subarachnoid hemorrhage']

answer: @entity510 :: (MESH:D013345,Disease) :: ['Aneurysmal Subarachnoid Hemorrhage']


abstract: PURPOSE: @entity191 ( @entity191 ) is the second most common @entity179 ; the safety and effects of radiation therapy on @entity191 are not well established. We report a @entity1 with @entity191 and a @entity1313 referred for radiation therapy and review the literature on this topic focusing on the incidence of @entity5 and @entity1313 in @entity191 , @entity1313 and radiation therapy as independent causes of @entity191 , and the safety and effect of radiation therapy, including functional radiosurgery, in @entity1 with @entity191 . METHODS AND MATERIALS: A PubMed literature review focusing on all English language publications from 1940 to 2014 identified 146 relevant articles, of which 91 discussed functional radiosurgery for @entity191 , 49 discussed "neoplastic @entity304 ," 4 discussed radiation-induced @entity304 , and 2 discussed the safety of fractionated radiation therapy in @entity1 with @entity191 . RESULTS: Odds ratios of 0.4 to 0.88 have been reported for the development of @entity5 in general among @entity1 with @entity191 , whereas the incidence ratios of @entity191 @entity1 developing a @entity1313 relative to the general population range from 0.9 to 1.61. @entity304 thought to arise as a sequelae of @entity5 growth have been described in 49 papers dating to 1953. We identified 4 reports of @entity191 that arose after radiation therapy, comprising a total of 7 @entity1 , including 5 adults and 2 pediatric @entity1 . Pediatric @entity1 showed a mixed response to @entity935 agonist therapy, whereas adults had little symptom improvement. Reports of @entity191 @entity1 irradiated in conventional fractionation for a variety of indications do not appear to indicate increased sensitivity to radiation therapy or exacerbated @entity191 symptoms after irradiation. Radiosurgery performed for management of refractory @entity400 in @entity191 @entity1 results in up to an 88% favorable outcome, with the onset of symptom improvement ranging from 3 days to 1 year and minimal @entity137 (not exceeding the @entity137 observed for the same stereotactic radiosurgery procedure performed for essential @entity400 in nonparkinsonian @entity1 ). CONCLUSIONS: @entity1 with @entity191 do not harbor an increased risk for the development of @entity5 in general and have similar incidence of @entity1313 as the general population. Tumor-induced @entity304 is a rare entity. @entity304 as a side effect of brain radiation is an uncommon phenomenon, even after high doses, but is associated with limited response to medical management. Rare cases in @entity1 , typically associated with bilateral imaging changes, have been described, which suggests possible uncommon genetic predisposition. There are no convincing reports that suggest that pre-existing @entity304 is worsened by radiation therapy, although a mechanistic possibility for this exists. Functional radiosurgery for management of refractory @entity400 in @entity191 @entity1 is safe and effective. Radiation therapy, either fractionated or stereotactic radiosurgery, appears to be safe when used judiciously for @entity1 with @entity191 , for the treatment of either @entity5 or @entity191 itself.

title: Should we irradiate a @entity1313 in a XXXX with @entity304 ? A case report and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinsonian symptoms', 'parkinsonism', 'Parkinsonism']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor', 'brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ['parkinsonian syndromes', "Parkinson's disease", 'PD']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: PURPOSE: Forme fruste @entity2941 (FFCC) is a @entity2941 that has minimal or no dilatation of the extrahepatic bile duct (EHBD) and is associated with pancreaticobiliary malunion (PBMU). The authors reviewed the long-term outcome of their @entity1 with FFCC. METHODS: Inpatient and outpatient records of 281 @entity1 with @entity2941 were reviewed. In this study, minimal dilatation of the EHBD was defined as its maximum diameter being less than 10 mm. RESULTS: There were 17 cases of FFCC identified. In all 17 @entity1 , PBMU was present. The mean age at EHBD excision was 2.9 years. Fourteen @entity1 had hepatico-jejunostomy, and three had hepatico-duodenostomy. The histology of the excised EHBD showed @entity9645 /sloughing (in 35.3% @entity1 ), @entity82 (52.9%), and inflammatory cell infiltration (41.2%). Over a mean postoperative follow-up period of 9.8 years, there have been no episodes of @entity255 or anastomotic stricture formation. CONCLUSIONS: The treatment of choice for FFCC in @entity1 is EHBD excision and hepatico-jejunostomy. There is little surgical morbidity if performed carefully.

title: Forme fruste XXXX : long-term follow-up with special reference to surgical technique.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity9645 :: ('MESH:D019226', 'Disease') :: ['mucosal ulceration']

entities_list: @entity2941 :: ('MESH:D015529', 'Disease') :: ['choledochal cyst']

entities_list: @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis']

answer: @entity2941 :: (MESH:D015529,Disease) :: ['choledochal cyst']


abstract: OBJECTIVE: Mutations in the @entity5345 gene confer a high risk for the development of @entity5344 . The aim of this study was to establish the frequency and spectrum of @entity5345 mutations in Czech @entity5344 families. SUBJECTS AND METHODS: We have screened 28 @entity1 with early-onset @entity5 and 54 @entity1 from risk families for germ-line mutations in @entity5345 . All coding exons were analyzed by the protein truncation test (PTT) and the reverse transcription polymerase chain reaction (RT-PCR). Detected variants were characterized by direct sequencing of PCR products. RESULTS: Five distinct deleterious mutations have been identified in six families. All the mutations led to the premature termination of translation. One mutation was detected in a group of 11 (9.1%) @entity1 with early-onset @entity0 . Two mutations were observed in 32 (6.3%) families with a history of @entity0 only. Three mutations were found in 22 (13.6%) families with both @entity5344 . The @entity26207 mutation was the only abnormality detected twice. In addition, two variant transcripts, the loss of exon 5 and in-frame 3-bp deletion at the beginning of exon 8, were identified only at the cDNA level. Their biological significance remains unknown. CONCLUSION: PTT analysis enables examination of long PCR products. The technique is useful for rapid detection of mutations in @entity0 .

title: Mutations of the @entity5345 gene in XXXX in the Czech Republic.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'hereditary breast cancer']

entities_list: @entity5344 :: ('MESH:D061325', 'Disease') :: ['breast and ovarian cancer', 'breast or ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity5344 :: (MESH:D061325,Disease) :: ['hereditary breast and ovarian cancer']


abstract: BACKGROUND AND PURPOSE: Vertebroplasty and kyphoplasty are frequently utilized in the treatment of symptomatic @entity174 . While prior studies have demonstrated @entity615 and care for @entity3604 @entity1 , disparities in spine augmentation have not been investigated. We investigated racial and health insurance status differences in the use of spine augmentation for the treatment of @entity3604 in the United States. MATERIALS AND METHODS: Using the Nationwide Inpatient Sample from 2005 to 2010, we selected all discharges with a primary diagnosis of @entity174 (International Classification of Diseases-9 code 733.13). @entity1 who received spine augmentation were identified by using International Classification of Diseases-9 procedure code 81.65 for vertebroplasty and 81.66 for kyphoplasty. @entity1 with a diagnosis of @entity5 were excluded. We compared usage rates of spine augmentation by race/ethnicity (white, black, Hispanic, and Asian/Pacific Islander) and insurance status (Medicare, Medicaid, self-pay, and private). Comparisons among groups were made by using   (2) tests. A multivariate logistic regression analysis was fit to determine variables associated with spine augmentation use. RESULTS: A total of 228,329 @entity1 were included in this analysis, of whom 129,206 (56.6%) received spine augmentation. Among @entity1 with spine augmentation, 97,022 (75%) received kyphoplasty and 32,184 (25%) received vertebroplasty; 57.5% (92,779/161,281) of white @entity1 received spine augmentation compared with 38.7% (1405/3631) of black @entity1 (P < .001). Hispanic @entity1 had significantly lower spine augmentation rates compared with white @entity1 (52.3%, 3777/7222, P < .001) as did Asian/Pacific Islander @entity1 (53.1%, 1784/3361, P < .001). The spine augmentation usage rate was 57.2% (114,768/200,662) among @entity1 with Medicare, significantly higher than that of those with Medicaid (43.9%, 1907/4341, P < .001) and those who self-pay (40.2%, 488/1214, P < .001). CONCLUSIONS: Our findings demonstrate substantial racial and health insurance-based disparities in the inpatient use of spinal augmentation for the treatment of @entity3604 .

title: Racial and Health Insurance Disparities of Inpatient Spine Augmentation for XXXX from 2005 to 2010.

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic vertebral fracture', 'osteoporotic vertebral fractures', 'osteoporotic']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['vertebral body fractures', 'vertebral fracture']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['disparities in the treatment of back pain']

answer: @entity3604 :: (MESH:D058866,Disease) :: ['Osteoporotic Vertebral Fractures']


abstract: OBJECTIVE: To identify sonographically the site and entity of alterations in a high number of @entity1 with @entity158 . METHODS: Two different experienced operators (both rheumatologists), who were blinded to the clinical data, performed sonographic examinations on 528 shoulders of 425 consecutive @entity1 with @entity158 shoulder and in both shoulders of 198 control subjects. They carried out ultrasound examinations separately using a 7.5 MHz linear transducer. Investigation included the @entity924 joint, glenohumeral joint, @entity5818 , subscapularis bursa, and finally identification of calcifications. Before the ultrasonographic exam, a third experienced rheumatologist performed a physical examination in all @entity1 using specific tests of movement for evaluation of the long head of @entity924 joint. RESULTS: Sonographic alterations were found in a total of 94.1% of @entity1 . The structure most frequently involved was the supraspinatus tendon (64.6%). The long head of the biceps tendon (48.1%) and the acromioclavicular joint (51.5%) were also frequently involved. Different types of alterations in the various structures were detected. Significant differences were found with respect to controls. A high sensitivity and specificity of sonography was demonstrated compared to physical examination. CONCLUSIONS: Sonography evaluates accurately the single anatomic structures of the shoulder and identifies both the site and type of changes in @entity1 with @entity158 shoulder. The high sensitivity/specificity, non-invasiveness and low costs of this technique justify its routine utilisation in clinical rheumatological practice.

title: Sonographic study of XXXX shoulder.

entities_list: @entity5818 :: ('MESH:D019534', 'Disease') :: ['subacromial-subdeltoid bursa']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['long head of the biceps tendon, the supraspinatus tendon, infraspinatus tendon, subscapularis tendon, acromioclavicular', 'biceps tendon, the supraspinatus tendon, infraspinatus tendon, subscapularis tendon, and acromioclavicular']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['shoulder pain', 'painful']

answer: @entity158 :: (MESH:D010146,Disease) :: ['painful']


abstract: OBJECTIVE: To assess diagnostic accuracy of cranial ultrasound (CUS) performed through the @entity1347 ( @entity1347 ) and @entity2267 ( @entity2267 ) in @entity548 ( @entity548 ) in very low birthweight (VLBW) @entity1 . SETTING: Third-level neonatal intensive care unit (NICU). DESIGN: VLBW @entity1 consecutively admitted at Gaslini @entity1 's Hospital between February 2012 and September 2013 underwent both CUS and MR susceptibility-weighted imaging (SWI). CUS was performed at days 1, 2, 3 and 7 after birth, then weekly until term-equivalent age. All CUS examinations were performed through @entity1347 and @entity2267 using an 8   Mhz convex probe. Depending on the size, CBHs were classified as massive, limited or microhaemorrhages. Diagnostic accuracy of CUS through @entity1347 and @entity2267 in detecting all types of CBHs was assessed by comparing it with SWI, used as the gold-standard technique. RESULTS: 140 VLBW @entity1 were included. CUS sensitivity in detecting massive @entity548 through both @entity1347 and @entity2267 was excellent (100%). However, CUS sensitivity through @entity1347 dropped down to 16.7% (95% CI 1% to 46%) in cases of limited @entity548 , with sensitivity through @entity2267 remaining good (83.3%; 95% CI 53% to 100%). None of the microhaemorrhages diagnosed by SWI was identified by CUS, despite the use of @entity2267 . Specificity of CUS in detecting all degrees of @entity548 through both @entity1347 and @entity2267 was excellent (100%). CONCLUSIONS: Routine use of @entity2267 allows a better detection of limited @entity548 when compared with @entity1347 . Overall sensitivity of CUS in detecting @entity548 is low when microhaemorrhages are included. In other words, microhaemorrhages proved to be undetectable by CUS.

title: Accuracy of ultrasound in assessing XXXX in very low birthweight babies.

entities_list: @entity1 :: ('9606', 'Species') :: ['Children', 'infants']

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['AF', 'anterior fontanelle']

entities_list: @entity2267 :: ('MESH:D008417', 'Disease') :: ['MF', 'mastoid fontanelle']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['CBH', 'detecting cerebellar haemorrhages']

answer: @entity548 :: (MESH:D006470,Disease) :: ['cerebellar haemorrhages']


abstract: OBJECTIVE: In @entity43 , detection of sentinel nodes is an upcoming procedure. Perioperative determination of the @entity1 's sentinel node(s) might prevent a radical lymphadenectomy and associated morbidity. It is essential to understand the lymphatic drainage pathways of the ovaries, which are surprisingly up till now poorly investigated, to predict the anatomical regions where sentinel nodes can be found. We aimed to describe the lymphatic drainage pathways of the @entity1 ovaries including their @entity8668 . METHODS: A series of 3 @entity1 female fetuses and tissues samples from 1 @entity1 cadaveric specimen were studied. Immunohistochemical analysis was performed on @entity982 -embedded transverse sections (8 or 10  m) using antibodies against @entity14600 , @entity2281 , and a-smooth muscle actin to identify the lymphatic endothelium, Schwann, and smooth muscle cells, respectively. Three-dimensional reconstructions were created. RESULTS: Two major and 1 minor lymphatic drainage pathways from the ovaries were detected. One pathway drained via the proper ligament of the ovaries (ovarian ligament) toward the lymph nodes in the obturator fossa and the internal iliac artery. Another pathway drained the ovaries via the suspensory ligament (infundibulopelvic ligament) toward the para-aortic and paracaval lymph nodes. A third minor pathway drained the ovaries via the round ligament to the inguinal lymph nodes. Lymph vessels draining the fallopian tube all followed the lymphatic drainage pathways of the ovaries. CONCLUSIONS: The lymphatic drainage pathways of the ovaries invariably run via the suspensory ligament (infundibulopelvic ligament) and the proper ligament of the ovaries (ovarian ligament), as well as through the round ligament of the uterus. Because @entity43 might spread lymphogenously via these routes, the sentinel node can be detected in the para-aortic and paracaval regions, obturator fossa and surrounding internal iliac arteries, and inguinal regions. These findings support the strategy of injecting tracers in both ovarian ligaments to identify sentinel nodes.

title: Understanding Lymphatic Drainage Pathways of the Ovaries to Predict Sites for Sentinel Nodes in XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity8668 :: ('MESH:D001882', 'Disease') :: ['compartmental fascia borders']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Ovarian Cancer']


abstract: BACKGROUND: Recurrent @entity4553 is a relatively common, yet challenging, condition for both the @entity1 and the surgeon. The literature on the treatment of recurrent @entity4553 is sparse. The purpose of this study was to evaluate prospectively the functional outcome and @entity1 satisfaction following the Lapidus procedure for the treatment of recurrent @entity4553 . METHODS: Twenty-four @entity1 with a total of twenty-six symptomatic recurrences of @entity4553 after previous procedures for treatment of the @entity85 were included in the study. Exclusion criteria included prior fusion procedures on the foot or ankle, a previous Keller or Mayo procedure, @entity1723 , @entity1095 , or @entity1897 . A visual analog @entity158 scale and the American Orthopaedic Foot and Ankle Society Hallux Metatarsophalangeal-Interphalangeal Scale were administered preoperatively, at six months postoperatively, and yearly thereafter. Weight-bearing radiographs were also made preoperatively; at six weeks, three months, six months, and one year postoperatively; and yearly thereafter. @entity1 satisfaction was assessed at the latest follow-up evaluation. RESULTS: At twenty-four months, the mean score according to the American Orthopaedic Foot and Ankle Society (AOFAS) Hallux Metatarsophalangeal-Interphalangeal Scale had increased from 47.6 to 87.9 points, the mean score according to the visual analog @entity158 scale had improved from 6.2 to 1.4, the mean @entity4553 angle had improved from 37.1 degrees to 17.1 degrees, and the mean intermetatarsal angle had improved from 18 degrees to 8.6 degrees. The @entity1 were very satisfied after 77% of the twenty-six procedures, satisfied after 4%, and somewhat satisfied after 19%; no @entity1 was dissatisfied. There were no cases of hallux varus. Complications included three nonunions, all of which occurred in smokers, and two superficial wound infections. CONCLUSION: In appropriately selected @entity1 , the Lapidus procedure is a reliable and effective operation after failed surgical treatment of @entity4553 . LEVEL OF EVIDENCE: Therapeutic study, Level IV (case series [no, or historical, control group]). See p. 2 for complete description of levels of evidence.

title: The Lapidus procedure as salvage after failed surgical treatment of XXXX : a prospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity4553 :: ('MESH:D006215', 'Disease') :: ['hallux valgus', 'hallux valgus deformity']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['insulin-dependent diabetes']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity']

answer: @entity4553 :: (MESH:D006215,Disease) :: ['hallux valgus']


abstract: BACKGROUND AND OBJECTIVE: Club cell secretory protein ( @entity10974 ) is a sensitive biomarker of airways epithelium integrity. It has gained interest as a biological marker in chronic @entity358 because of its presumed relationship to @entity32 . Little is known about the association between @entity10974 serum level and @entity565 , lung function and @entity1224 ( @entity1224 ). METHODS: Serum @entity10974 level was determined by latex immunoassay in 1298 @entity1 from the French Epidemiological case-control and family-based study on Genetics and Environment of Asthma (EGEA) (mean age 43 years; 49% @entity1 , 38% with @entity565 ). Pre-bronchodilator lung function (forced expiratory volume in 1   s (FEV1), forced vital capacity (FVC) and FEV1/FVC) and degree of @entity1224 , expressed as a function of the dose-response slope to @entity2710 test were measured. Standardized residuals @entity10974 z-scores were obtained by regressing @entity10974 level on the glomerular filtration rate. @entity10974 z-scores were correlated with @entity565 , lung function and @entity1224 in @entity1 with and without @entity565 . RESULTS: @entity10974 geometric mean level was 12.4    g/L (range: 2.2-70.6    g/L). In @entity1 without @entity565 , lower @entity10974 z-scores was associated with impaired FEV1/FVC% (b   =   0.50 (95% CI: 0.06, 0.95) and with higher degree of @entity1224 (b   =   0.24 (95% CI: 0.09, 0.39)). @entity10974 was not associated with @entity73 or @entity1224 in @entity1 with @entity565 . CONCLUSIONS: Lower @entity10974 serum level was associated with @entity73 and @entity1224 , suggesting that serum @entity10974 level may reflect early damages to the lung epithelium in adults without @entity565 .

title: Serum club cell protein 16 is associated with asymptomatic @entity1224 in adults: Findings from the French epidemiological study on the genetics and environment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired lung function']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung diseases']

entities_list: @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']

entities_list: @entity1224 :: ('MESH:D000402', 'Disease') :: ['AR', 'airway responsiveness']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: PURPOSE: To assess the prevalence of @entity1209 ( @entity1209 ) after Le @entity196 with and without the use of a multimodal antiemetic protocol shown to decrease @entity1209 ( @entity1209 ). MATERIALS AND METHODS: Consecutive @entity1 undergoing Le @entity196 with or without additional procedures at a single academic institution formed the intervention cohort for an institutional review board-approved prospective clinical trial with a retrospective comparison group. The intervention cohort was managed with a multimodal antiemetic protocol. The comparison group consisted of consecutive @entity1 who underwent similar surgical procedures at the same institution before protocol implementation. All @entity1 were asked to complete a postdischarge diary documenting the occurrence of @entity390 and @entity391 . Those who completed the diaries were included in this analysis. Data were analyzed with the Fisher exact test and the Wilcoxon rank sum test. A P value less than .05 was considered significant. RESULTS: Diaries were completed by 85% of @entity1 in the intervention group (79 of 93) and 75% of @entity1 in the comparison group (103 of 137). @entity1 in the intervention (n  = 79) and comparison (n  = 103) groups were similar in the proportion of @entity1 with validated risk factors for @entity1209 , including female gender, history of @entity1209 , age younger than 50  years, opioid use in the postanesthesia care unit (PACU), and @entity390 in the PACU (P  = .37). The prevalence of @entity1209 was unaffected by the antiemetic protocol. After discharge, @entity390 was reported by 72% of @entity1 in the intervention group and 60% of @entity1 in the comparison group (P  = .13) and @entity391 was reported by 22% of @entity1 in the intervention group and 29% of @entity1 in the comparison group (P  = .40). CONCLUSION: Modalities that successfully address @entity1209 after Le @entity196 might fail to affect @entity1209 , which is prevalent in this population. Future investigation will focus on methods to minimize @entity1209 .

title: Postdischarge @entity390 and Vomiting Remains Frequent After Le Fort I Osteotomy Despite Implementation of a Multimodal Antiemetic Protocol Effective in Reducing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['Fort I osteotomy']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['PDNV', 'postdischarge nausea and vomiting', 'PONV', 'postoperative nausea and vomiting']

answer: @entity1209 :: (MESH:D020250,Disease) :: ['Postoperative Nausea and Vomiting']


abstract: PURPOSE: To refine a preliminary analysis identifying a possibly increased prevalence of @entity600 among @entity1 born to @entity1 exposed to @entity903 in the first trimester. METHODS: This study used data from UnitedHealthcare, a large U.S. insurer, using datasets originally for a study of @entity752 in pregnancy. We identified @entity1 with a live-born delivery between January 1995 and September 2004. We classified @entity1 according to their first trimester mono- or mono/polytherapy exposure to @entity903 and other antidepressants. We confirmed @entity600 cases by medical record abstraction. We calculated the adjusted odds ratios (AORs) through logistic regression. RESULTS: For @entity903 , there were 815 @entity1 among 791 @entity1 exposed as monotherapy, and 1020 @entity1 among 989 @entity1 exposed as mono- or polytherapy. For other antidepressants, there were 4198 @entity1 among 4072 @entity1 exposed as monotherapy, and 4936 @entity1 among 4767 @entity1 exposed as mono- or polytherapy. AORs for all @entity600 associated with @entity903 were 1.89 (95%CI 1.20-2.98) for monotherapy, and 1.76 (95%CI 1.18-2.64) for mono- or polytherapy. AORs for @entity65 associated with @entity903 were 1.46 (95%CI 0.74-2.88) for monotherapy, and 1.68 (95%CI 0.95-2.97) for mono- or polytherapy. CONCLUSIONS: These more detailed @entity903 findings confirm previous findings of analyses of these data among @entity1 exposed to all types of antidepressants. The present findings are consistent with other recent results suggesting the possibility of a modestly increased occurrence of @entity600 following first trimester exposure to @entity903 compared to other antidepressants.

title: @entity903 in the first trimester and the prevalence of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'infants']

entities_list: @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'congenital malformations', 'malformation']

entities_list: @entity752 :: ('MESH:D016642', 'Chemical') :: ['bupropion']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular malformations']

answer: @entity600 :: (MESH:D000014,Disease) :: ['congenital malformations']


abstract: BACKGROUND: This study aims to evaluate whether withdrawal of a soy oil-based lipid emulsion from the @entity3147 ( @entity3147 ) regimen in @entity1 is associated with improved @entity412 and liver enzyme concentrations. METHODS: In this retrospective study, @entity1 with @entity2298 (>4.50 mmol/L) while receiving @entity3147 were retrieved from a prospective complication registration database. @entity1 received Intralipid 20% as part of an all-in-one system containing all necessary macro- and micronutrients, electrolytes, trace elements, and vitamins. RESULTS: Forty @entity1 with @entity2298 were included. Lipid emulsions were withdrawn from the all-in-one mixture for a median of 5 (range, 1-23) days, after which @entity412 concentrations decreased significantly (mean difference -2.5    0.30 mmol/L, P < .001). @entity492 aminotransaminase and leukocyte count decreased significantly (mean difference -35    17 U/L, P = .049 and -3.8    1.7*10E9/L, P = .028, respectively), whereas albumin level increased significantly (mean difference 2.1    0.9 g/L, P = .027). @entity493 aminotransaminase showed a nonsignificant reduction (mean difference -30    22 U/L, P = .194). In 11 @entity1 , the lipid emulsion was reintroduced, after which @entity412 levels showed a significant increase (mean difference 1.5    0.30 mmol/L, P = .001). CONCLUSIONS: Short-term withdrawal of the lipid fraction in the @entity3147 mixture is associated with a significant reduction of plasma @entity412 concentration. Reintroduction was related to an increase of @entity412 concentration. In addition, liver enzyme abnormalities and leukocyte count reduced, whereas albumin levels increased, suggesting that even short withdrawal of the lipid emulsion diminished @entity16 .

title: Treatment of XXXX in @entity1 receiving @entity3147 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'humans', 'patients']

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['hepatocellular damage and systemic inflammation']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['Aspartate']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['parenteral nutrition', 'PN']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['Alanine']

answer: @entity2298 :: (MESH:D015228,Disease) :: ['hypertriglyceridemia']


abstract: STUDY DESIGN: Retrospective analysis of the National Surgical Quality Improvement Program (NSQIP), a prospectively collected multicenter surgical outcomes database. OBJECTIVE: To determine the effect of preoperative nutritional status, as measured by serum albumin concentration, on outcomes following anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA: Nutritional status has been shown to be an important predictor of postoperative recovery and outcomes. Serum albumin concentration is an established marker of overall nutrition and @entity262 , however, its correlation to outcomes following ACDF is unknown. METHODS: ACDF cases from 2005 to 2010 were identified in the NSQIP and categorized by preoperative serum albumin: normal (>= 3.5 g/dL), hypoalbuminemic (<3.5 g/dL), or not measured. Independent demographic and comorbidity variables were assessed, including American Society of Anesthesiologists (ASA) classification. Risk factors for @entity260 were identified, including preoperative @entity4988 , and incorporated into a multivariable logistic regression model to determine the strength of preoperative @entity4988 as an adjusted predictor of @entity260 . RESULTS: There were 3671 ACDF cases, of which 1382 (37.6%) had preoperative albumin measurements. @entity1 with albumin measurements were older and more likely to have higher ASA class, @entity101 , and @entity6 . Hypoalbuminemic @entity1 had higher rates of having any major @entity260 (s), specifically @entity358 , @entity299 , and reoperation, relative to those with normal albumin (all P<0.01). These @entity1 also had longer lengths of stay (5.0 vs. 1.9 d). With multivariable regression, preoperative @entity4988 was a strong independent predictor of @entity260 , with an adjusted odds ratio of 3.37 (P=0.003). CONCLUSIONS: In this analysis of a prospective surgical outcomes database, preoperative serum @entity4988 was an important adjunct predictor of major complications following ACDF. In high-risk @entity1 with multiple medical comorbidities, we recommend that clinicians consider nutritional screening and optimization as part of preoperative risk assessment.

title: Preoperative Nutritional Status as an Adjunct Predictor of Major XXXX Following Anterior Cervical Discectomy and Fusion.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['major postoperative complications', 'postoperative complication']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac complications']

answer: @entity260 :: (MESH:D011183,Disease) :: ['Postoperative Complications']


abstract: UNASSIGNED: Damage to the medial temporal lobe (MTL) has long been known to impair declarative memory, and recent evidence suggests that it also impairs visual perception. A theory termed the representational-hierarchical account explains @entity73 by assuming that MTL stores conjunctive representations of items and events, and that individuals with @entity75 must rely upon representations of simple visual features in posterior visual cortex, which are inadequate to support memory and perception under certain circumstances. One recent study of visual discrimination behavior revealed a surprising antiperceptual learning effect in MTL-damaged individuals: With exposure to a set of visual stimuli, discrimination performance worsened rather than improved [Barense, M. D., Groen, I. I. A., Lee, A. C. H., Yeung, L. K., Brady, S. M., Gregori, M., et al. Intact memory for irrelevant information impairs perception in @entity2730 . Neuron, 75, 157-167, 2012]. We extend the representational-hierarchical account to explain this paradox by assuming that difficult visual discriminations are performed by comparing the relative "representational tunedness"-or familiarity-of the to-be-discriminated items. Exposure to a set of highly similar stimuli entails repeated presentation of simple visual features, eventually rendering all feature representations maximally and, thus, equally familiar; hence, they are inutile for solving the task. Discrimination performance in @entity1 with @entity75 is therefore impaired by stimulus exposure. Because the unique conjunctions represented in MTL do not occur repeatedly, healthy individuals are shielded from this perceptual interference. We simulate this mechanism with a neural network previously used to explain recognition memory, thereby providing a model that accounts for both @entity51 caused by @entity75 with a unified architecture and mechanism.

title: A Computational Model of Perceptual and XXXX in Medial Temporal Lobe @entity2730 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['MTL lesions', 'MTL damage']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['such impairments']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['mnemonic and perceptual deficits']

answer: @entity51 :: (MESH:D009461,Disease) :: ['Mnemonic Deficits']


abstract: OBJECTIVE: To determine the incidence and type of mixoploidy in @entity1 blastocysts produced in vitro. DESIGN: A laboratory study of spare blastocysts from an IVF program. SETTING: University hospital laboratory. @entity1 (S): Thirty-nine couples undergoing IVF or intracytoplasmic sperm injection. INTERVENTION(S): A total of 103 blastocysts were classified as good- or poor-quality blastocysts based on morphology. A total of 6,927 interphase nuclei, 5,015 from 59 good-quality and 1,912 from 44 poor-quality blastocysts, were assessed for ploidy by fluorescence in situ hybridization with chromosome-specific DNA probes. MAIN OUTCOME MEASURE(S): The percentage and the type of @entity5700 cells present in each blastocyst. RESULT(S): Mixoploidy (mixture of diploid and @entity5700 cells) was found in 86% of good-quality and 82% of poor-quality blastocysts analyzed. The type of @entity5700 ranged from 3N to 14N, with tetraploidy being the most common between both groups. The proportion of @entity5700 cells per mixoploid blastocyst ranged from 1% to 88%. The percentage of @entity5700 nuclei within most good-quality mixoploid blastocysts was small (10%) and significantly lower than in poor-quality blastocysts (19%). CONCLUSION(S): Most @entity1 blastocysts produced in vitro contain @entity5700 , predominantly @entity8339 cells. The proportion of @entity5700 cells in the majority of good-quality blastocysts is low. The small numbers of blastocysts with a high percentage of @entity5700 cells may have implications for blastocyst transfer.

title: High rate of mixoploidy among XXXX blastocysts cultured in vitro.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'PATIENT']

entities_list: @entity5700 :: ('MESH:D011123', 'Disease') :: ['polyploid', 'polyploidy']

entities_list: @entity8339 :: ('MESH:D057891', 'Disease') :: ['tetraploid']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: @entity955 ( @entity955 ) is found in 1% of @entity1 above the age of 60 years. More than 5% of the population older than 69 years and about 14% of octogenarians are at risk for this @entity943 . It is estimated that 1.5 to 3 million @entity1 in the United States alone suffer from @entity955 . The public health implications and attendant morbidity are a significant drain on our health care system. HYPOTHESIS: The purpose of this study was to determine the clinical and echocardiographic predictors of success in converting @entity955 of > or = 24 h duration. METHODS: Demographic and clinical and echocardiographic parameters of 101 @entity1 with recent onset @entity955 (> 24 h) who received @entity2780 were studied. RESULTS: Of 101 @entity1 , 56 (55%) converted to sinus rhythm. Age, gender, @entity101 , @entity6 , left ventricular ejection fraction (< or = 35%), @entity712 , and previous medication for rate control had no significant effect on the conversion rate. Conversion rate was only 30% (9/30 @entity1 ) in the presence of an enlarged left atrium (LA > or = 5 cm) and 37.7% (23/61 @entity1 ) in the presence of @entity339 ( @entity339 ), whereas the conversion rate was 82.5% (33/40 @entity1 ) in the absence of @entity339 and 85% (29/34 @entity1 ) in the absence of both enlarged LA and @entity339 (p = <0.001). @entity1 with @entity453 ( @entity453 ) also exhibited a significantly greater response to @entity2780 than @entity1 without @entity453 (77 vs. 46%, p-value 0.005). CONCLUSION: As a therapy for cardioversion of @entity955 , @entity2780 is most effective in a selected subgroup @entity1 , such as in @entity1 with @entity453 and in @entity1 without @entity339 and/or markedly enlarged left atrium.

title: Cardioversion of @entity955 with XXXX : when is it most effective?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'persons']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral valve disease', 'MVD']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity2780 :: ('MESH:C067192', 'Chemical') :: ['ibutilide']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial fibrillation', 'AF']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity2780 :: (MESH:C067192,Chemical) :: ['ibutilide']


abstract: OBJECTIVE: Lowering low-density lipoprotein @entity165 ( @entity11429 ) with statins reduces @entity65 and slows plaque progression. While this therapeutic approach has been reported to favorably modify plaque composition, this is not well characterized in @entity1 . Also, the benefit of achieving @entity11429 levels below current recommended targets remains unknown. Frequency-domain optical coherence tomography (FD-OCT) enables visualization of plaque microstructures associated with plaque instability. We investigated plaque morphologies in @entity1 with low @entity11429 levels by using FD-OCT. METHODS: 293 and 122 non-obstructive lipid and fibrous plaques in 280 stable @entity6817 -treated CAD @entity1 were evaluated by FD-OCT imaging in vessels requiring percutaneous coronary intervention. Study subjects were stratified according to achieved @entity11429 levels (<50, 50-70, 70-100, <100  mg/dL). FD-OCT derived plaque microstructures were compared. RESULTS: @entity11429 levels <50  mg/dL and <70  mg/dL were observed in 13.9% (39/280) and 29.2% (82/280) of @entity1 , respectively. @entity1 with @entity11429 <50  mg/dL were more likely to be older (p  <  0.001) and receive a high-dose @entity6817 (p  =  0.01). On FD-OCT imaging, @entity1 with @entity11429 <50  mg/dL were more likely to have @entity82 (51.7, 43.2, 22.2 and 12.3%, p  =  0.01) and less likely to have lipid plaques (48.2, 56.7, 77.7 and 87.6%, p  =  0.01). In addition, @entity11429 level was significantly associated with lipid arc (173      76, 175      88, 196      102 and 234      85  , p  =  0.01) and fibrous cap thickness (139.9      93.9, 103.1      66.4, 92.5      48.5 and 92.1      47.8 um, p  =  0.001). In particular, the smallest lipid arc and thickest fibrous cap were observed in @entity1 who achieved @entity11429 <50  mg/dL. Multivariable analysis revealed @entity11429 levels (beta coefficient  -0.254, p  =  0.009) and high-dose @entity6817 use (beta coefficient 1.814, p  =  0.003) to independently associate with fibrous cap thickness. CONCLUSIONS: More stable plaque features were observed within non-obstructive @entity1856 in @entity1 with very low @entity11429 levels. These findings underscore @entity11429 level to stabilize plaques in @entity1 with CAD and high residual atherosclerotic risk.

title: Plaque microstructures in @entity1 with coronary artery disease who achieved very low low-density lipoprotein XXXX levels.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'humans', 'patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrous plaque']

entities_list: @entity1856 :: ('MESH:D058226', 'Disease') :: ['atheromas']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: BACKGROUND: @entity120 ( @entity120 ) is a significant cause of morbidity and mortality in @entity1 suffering from @entity358 . Diagnosis of @entity120 has always been a major clinical dilemma due to its non-specific clinical manifestations. However, diagnosing @entity120 and determining its severity are essential for the prognosis and treatment planning in @entity120 @entity1 . This study aimed at evaluating the correlation between the pulmonary artery diameter (PAD) in the @entity551 (PAP) in echocardiography of @entity1 . MATERIALS AND METHODS: PAD was evaluated in the CT-scan of 117 @entity1 suffering from @entity401 ( @entity401 ) and the correlation between PAD and PAP was studied. A receiver operating characteristic curve (ROC curve) which is indicative of the precision of the diagnostic test was drawn to find the cut off point for the MPAD representing @entity120 . The area under the curve was also calculated in order to define the discriminative power of the test. RESULTS: PAP higher than 25 mmHg was considered as @entity120 . PAD over 29 mm reported in the CT-scan for the diagnosis of @entity120 in @entity401 @entity1 had sensitivity of 63% and specificity of 41.5%. No significant linear correlation was found between PAD and PAP (P-value = 0.17, r = 0.15). The area under the ROC curve was calculated to be 0.49 in the cutoff point of 29 mm for determining @entity120 (CI 95% = 0.38-0.60, P = 0.89). CONCLUSION: ROC curve showed a weak discriminative power. PAD had low sensitivity and specificity in the CT-scan for the diagnosis of @entity120 . Therefore, we conclude that CT-scan alone is not helpful in finding @entity120 cases and further examinations are required.

title: Correlation between the Pulmonary Artery Pressure Measured in Echocardiography and Pulmonary Artery Diameter in the CT-Scan of XXXX Suffering from @entity401 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['Pulmonary hypertension', 'PH']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary parenchymal diseases']

entities_list: @entity401 :: ('MESH:D017563', 'Disease') :: ['ILD', 'interstitial lung disease']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['CT-scan and pulmonary artery pressure']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Fifteen @entity1 with treatment-refractory @entity14 were enrolled on a phase 1b study of Pexa-Vec (pexastimogene devacirepvec; JX-594), an oncolytic and immunotherapeutic vaccinia designed to selectively replicate in @entity5 cells. Pexa-Vec was administered intravenously every 14 days, at dose levels of 1   *   10(6), 1   *   10(7), or 3   *   10(7) plaque-forming units (pfu)/kg. The primary endpoint was to determine the maximum tolerated dose. Secondary endpoints were pharmacokinetics and pharmacodynamics as well as antitumor activity. @entity1 were heavily pretreated (mean 4.5 lines of therapy). All @entity1 received at least two Pexa-Vec doses (median = 4; range = 2-4). No dose-limiting @entity137 were reported, and the maximum tolerated dose was not reached. The most common adverse events were grade 1/2 flu-like symptoms, generally lasting <24 hours. During the first and last cycles, genome pharmacokinetics were unchanged. Infectious pfu could be detected in plasma up to 2 hours after cycle 1 and up to 30 minutes after cycle 4 (when antivaccinia antibody titers are known to have peaked). Ten @entity1 (67%) had radiographically stable disease. Given the acceptable safety profile of multiple intravenous Pexa-Vec infusions in @entity1 with treatment-refractory @entity14 , further trials evaluating efficacy of intravenous Pexa-Vec, as monotherapy or in combination with chemotherapeutic agents, is warranted in this @entity1 population.

title: Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: BACKGROUND: We evaluated the reliability of intact @entity461 (iPTH) levels 4 hours after thyroidectomy (4h-iPTH) as a predictor of @entity3747 in a large series of @entity1 . METHODS: A prospective experimental design involving 523 consecutive @entity1 between September 1, 2004, and June 30, 2005, was employed. The specificity, sensitivity, and overall accuracy of 4h-iPTH in predicting post-thyroidectomy @entity3747 and symptoms were determined. RESULTS: A total of 199 @entity1 developed @entity3747 (serum @entity460 concentrations <8.0 mg/dl). Five @entity1 still were receiving @entity560 /oral @entity460 at 6 months after the operation. Seventy-three @entity1 experienced mild symptoms. The 4h-iPTH levels were reduced in @entity14645 @entity1 (28.8 +/- 15.3 vs 11.2 +/- 11.6 pg/ml) (P < .001). The 4h-iPTH levels were within the normal range (10 to 65 pg/ml) in 360 @entity1 (290 normocalcemic) and subnormal in 163 @entity1 (129 @entity14645 , of whom 62 were symptomatic). The accuracy of 4h-iPTH levels <10 pg/ml in predicting post-thyroidectomy @entity3747 and symptoms was 80.1% and 78.6%, respectively. False-negative results were observed in 70 @entity14645 @entity1 (13.4%), 11 of whom were symptomatic (2.1%). CONCLUSIONS: Subnormal 4h-iPTH levels alone did not accurately predict clinically relevant postoperative @entity3747 . The optimal cut-off level and its integration with preoperative and postoperative serum @entity460 concentrations should be reconsidered.

title: @entity461 levels 4 hours after surgery do not accurately predict post-thyroidectomy XXXX .

entities_list: @entity3747 :: ('MESH:D006996', 'Disease') :: ['hypocalcemia']

entities_list: @entity14645 :: ('MESH:C562689', 'Disease') :: ['hypocalcemic']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone']

entities_list: @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']

answer: @entity3747 :: (MESH:D006996,Disease) :: ['hypocalcemia']


abstract: A long-term, large-scale ethnic armed conflict continues in @entity3595 Lanka, where militant separatists control a northern section of the island. The conflict has resulted in a large population of internally displaced @entity1 and a shortage of medical staff. Drug and equipment shortages compound the difficulty in access to medical care. This article reports the experiences from 1 November 2000 to 30 April 2001 recorded by review of medical records and by interviews, in the peripheral unit, in a separatist controlled area of the Mallavi maternity ward. There were 704 births. Most of the mothers had been displaced by the war (69.5 per cent) and had experienced food shortage (67.5 per cent). Referred @entity1 (18.1 per cent) had a high rate of caesarean section (44.3 per cent) and had travelled a mean of 57.6 km to reach Mallavi. There had been substantial antenatal care (94.0 per cent), @entity116 toxoid vaccination (95.1 per cent) and @entity311 prophylaxis (86.4 per cent). Risk factors for low birth weight included a maternal body mass index less than 19 ( @entity4736 .55, CI 1.11-2.16, P = .011), primiparity ( @entity4736 .44, CI 1.05-1.97, P = .024) and self-reported @entity281 during pregnancy ( @entity4736 .42, CI 1.03-1.97, P = .036). Rates of low birth weight, @entity2209 , neonatal deaths and maternal mortality in the Mallavi units were higher than the @entity3595 Lankan national averages. Improvements in quality of care and access to health care are unlikely while the war continues.

title: Obstetrics during Civil War: six months on a maternity ward in Mallavi, northern XXXX Lanka.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirths']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['malarial infection']

answer: @entity3595 :: (6717,Gene) :: ['Sri']


abstract: BACKGROUND: Reduced cognitive performance and high prevalence of @entity308 have been reported in @entity1 with @entity712 ( @entity712 ) and severe @entity1002 . However, effects of contemporary device therapy on cognitive performance and @entity308 symptoms have not been studied thoroughly. METHODS: Seventy-four consecutive @entity712 @entity1 -45 receiving a biventricular defibrillator (CRT-D) and 29 receiving an @entity5748 ( @entity1479 ) as a control group-were enrolled in this investigator-initiated, prospective, controlled, and investigator-blinded study. A set of neuropsychological tests (mini-mental state examination, DemTect, age-concentration test, and Beck @entity308 inventory) was performed before, at 3 and at 6 months after device implantation. RESULTS: DemTect-score improved significantly (F = 7.8; P = 0.007) after CRT-D-implantation compared with @entity1479 . Age-concentration test revealed better concentration ability after CRT-D-implantation (F = 8.3; P = 0.005) compared with @entity1479 . Under CRT-D mini-mental state examination showed a significant improvement (F = 4.2; P = 0.043). CRT with defibrillator therapy also improved @entity308 revealed by beck @entity308 inventory (F = 14.7; P< 0.001) compared with @entity1479 . CONCLUSION: This prospective study is the first to demonstrate @entity73 by resynchronization therapy in @entity712 @entity1 with severe @entity1002 . In contrast to @entity1479 therapy, the beneficial effect of CRT-D on psycho-cognitive performance might be attributed to improved cardiac function and haemodynamics.

title: Cardiac resynchronization therapy improves psycho-cognitive performance in XXXX with @entity712 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['psycho-cognitive improvement']

entities_list: @entity5748 :: ('MESH:D009105', 'Disease') :: ['implantable single or dual-chamber defibrillator']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND AIM: The authors present a retrospective analysis of 14 @entity1 treated for @entity279 ( @entity279 ). This study was conducted to evaluate and compare the difference of functional outcomes associated with the extent of surgical @entity5 . METHODS: Eleven @entity1 were male and three were female, with a mean age of 37.2 years (19-62 years). Pre- and postoperative magnetic resonance imaging was performed in all cases. Preoperative angiography was performed in 11 cases and preoperative embolization in four. The follow-up period ranged from 15 to 161 months (median, 47 months). RESULTS: Thirteen @entity1 had @entity5 , and the remaining one had an extradural lesion. All @entity1 underwent surgical removal, and total removal (TR) was achieved in 10 cases. In four @entity1 with preoperative embolization, @entity954 was minimal and TR was possible. In three of four @entity1 without TR, their functional outcomes were aggravated postoperatively. At the last follow-up (15-161 months), eight @entity1 were improved, three were stationary, and three deteriorated. All @entity1 who showed improvements underwent TR. The statistical analysis showed that TR produced a significantly better outcome than incomplete removal (p = 0.015). CONCLUSION: TR resulted in a better outcome for @entity279 . Preoperative embolization could be effective in the @entity954 and facilitate TR with an improved surgical outcome.

title: XXXX : surgical strategy and clinical outcome.

entities_list: @entity279 :: ('MESH:D018325', 'Disease') :: ['spinal cord hemangioblastoma', 'SCH']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['intramedullary tumor', 'removal of the tumor']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['reduction of intraoperative bleeding', 'intraoperative bleeding']

answer: @entity279 :: (MESH:D018325,Disease) :: ['Spinal cord hemangioblastoma']


abstract: OBJECTIVES: We determined the prevalence and associated risk factors of @entity101 in Hispanic elders, ages 60-92 years, living in Massachusetts. DESIGN: Cross-sectional study. SETTING: State of Massachusetts. SUBJECTS: A representative sample of 597 Hispanics of Caribbean origin (77% Puerto Ricans and 23% Dominicans) and 243 non-Hispanic Whites from the same neighborhoods. MEASURES: Blood pressure, income, health behaviors, chronic conditions, body mass index (BMI), and waist circumference. RESULTS: @entity101 was prevalent in all groups: 66% for Puerto Rican and 73% Dominican @entity1 , 69% for non-Hispanic White @entity1 ; and 75%, 76%, and 74% for @entity1 in these groups, respectively. Twenty-one percent of Puerto Rican and 15% of Dominican @entity1 had systolic @entity101 , compared to 9% for non-Hispanic White @entity1 (P < .01 anti P < .05, respectively). The prevalence of systolic @entity101 was 14% and 21% for Puerto Rican and Dominican @entity1 , compared to 13% for non-Hispanic White @entity1 (not significant). Puerto Rican @entity1 with @entity101 were less likely to have their blood pressure under control than were non-Hispanic While @entity1 . Puerto Rican and Dominican elders remained more than 2.6 times more likely to have systolic @entity101 than non-Hispanic White elders after adjusting potential confounders. CONCLUSION: @entity101 is prevalent in this population and systolic @entity101 is more prevalent among Hispanic vs non-Hispanic White elders. Investigation of genetic or other factors associated with this apparent excess risk of systolic @entity101 among elderly Hispanics, particularly among @entity1 , is warranted.

title: XXXX among Hispanic elders of a Caribbean origin in Massachusetts.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertension']


abstract: The objective of the present study was to test the hypothesis that endogenous @entity37491 ( @entity37491 ) activation contributes to left ventricular (LV) and @entity409 in @entity712 (CHF). Stimulation of the beta(3)-AR inhibits cardiac contraction. In the failing myocardium, beta(3)-ARs are upregulated, suggesting that stimulation of beta(3)-ARs may contribute to depressed cardiac performance in CHF. We assessed the functional significance of endogenous beta(3)-AR activation in 10 conscious @entity235 before and after pacing-induced CHF. Under normal conditions, L-748,337, a specific beta(3)-AR antagonist, produced a mild increase in LV contractile performance assessed by the slope (E(es)) of the LV pressure-volume relation (18%, 6.2 +/- 0.9 vs. 7.3 +/- 1.2 mmHg/ml, P < 0.05) and the improved LV relaxation time constant (tau; 28.4 +/- 1.9 vs. 26.8 +/- 1.0 ms, P < 0.05). After CHF, the plasma @entity1063 concentration increased eightfold, and L-748,337 produced a larger increase in E(es) (34%, 3.8 +/- 0.7 vs. 5.1 +/- 0.8 mmHg/ml, P < 0.05) and a greater decrease in tau (46.4 +/- 4.2 vs. 41.0 +/- 3.9 ms, P < 0.05). Similar responses were observed in isolated myocytes harvested from LV biopsies before and after CHF. In the normal myocyte, L-748,337 did not cause significant changes in contraction or relengthening. In contrast, in CHF myocytes, L-748,337 produced significant increases in contraction (5.8 +/- 0.9 vs. 6.8 +/- 0.9%, P < 0.05) and relengthening (33.5 +/- 4.2 vs. 39.7 +/- 4.0 microm/s, P < 0.05). The L-748,337-induced myocyte response was associated with improved intracellular @entity141 concentration regulation. In CHF myocytes, @entity5894 caused a decrease in contraction and relengthening, and adding @entity3044 to @entity5894 caused a further @entity308 of myocyte function. Stimulation of beta(3)-AR by endogenous @entity2922 contributes to the @entity308 of LV contraction and relaxation in CHF.

title: Endogenous XXXX activation contributes to left ventricular and @entity409 in @entity712 .

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['cardiomyocyte dysfunction']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

entities_list: @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity37491 :: (442979(Tax:9615),Gene) :: ['beta3-adrenoreceptor']


abstract: AIMS: Factors predicting outcomes after MitraClip implantation are not well defined. We aimed to report the influence of baseline renal function on short-term outcomes of @entity1 enrolled in the investigator-initiated German transcatheter mitral valve interventions (TRAMI) registry. METHODS AND RESULTS: Twenty participating German centres prospectively included 778 @entity1 (mean age 76.0 years [71-81], 38.8% female gender) at high surgical risk (mean logistic EuroSCORE 20% [12-32%]) undergoing TMVR with the MitraClip for the treatment of symptomatic functional (70%) or degenerative (30%) @entity339 (FMR, DMR). The @entity1 were stratified according to renal function before clip implantation. The prevalence of moderate to severe @entity8 (glomerular filtration rate [GFR] <60 ml/min) was 62.7% (37.3%, normal renal function [GFR >60 ml/min]; 49.6%, moderate @entity8 [GFR 30-60 ml/min]; 13.1%, severe @entity8 [GFR <30 ml/min]). TMVR was successfully completed in 98.2% of cases; acute procedural failure, in-hospital and 30-day mortality rates were 1.8%, 2.3% and 4.4%, respectively. Acute procedural failure and mortality rates (in-hospital, 30-day) were significantly higher in @entity1 with severe @entity8 (5.9%, 7.8%, 14.1%), as compared to @entity1 with moderately (1%, 1.3%, 3.0%) or mildly impaired to normal (1.4%, 1.7%, 2.9%) renal function (p<0.0001). Following Cox regression analysis, the prevalence of severe @entity8 at the time of TMVR was the only predictor for increased 30-day mortality rates (hazard ratio 3.42, 95% confidence interval 1.88-6.2; p<0.0001). CONCLUSIONS: Renal function at the time of interventional mitral valve repair with the MitraClip system is a strong predictor for procedural outcomes. @entity1 with severe @entity8 have a more than threefold increased risk for acute procedural failure, in-hospital death and 30-day mortality.

title: Predictors for short-term outcomes of @entity1 undergoing transcatheter mitral valve interventions: analysis of 778 prospective XXXX from the German TRAMI registry focusing on baseline renal function.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral valve regurgitation']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIMS: In order to reduce social inequality in @entity5 survival, knowledge is needed about where in the @entity5 trajectory disparities occur, and how social and health-related aspects may interact. We aimed to determine whether socioeconomic factors are related to @entity5 diagnosis stage, and whether socioeconomic disparities in survival after @entity43 can be explained by socioeconomic differences in @entity5 stage, comorbidity, treatment or lifestyle factors. METHODS: In the Danish Gynaecological Cancer Database we identified 2873 cases of @entity43 diagnosed between 2005 and 2010. From this data we retrieved information on prognostic factors, treatment information and lifestyle factors. Age, vital status, comorbidity, education, income and cohabitation status were ascertained from nationwide administrative registers. Associations were analyzed with logistic regression and Cox regression models. RESULTS: Educational level was weakly associated with @entity5 stage. Short education, lower income and living without a partner were related to poorer survival after @entity43 . Among @entity1 with @entity5 stage, HR (95% CI) for @entity204 was 1.75 (1.20-2.54) in shorter compared to longer educated @entity1 . After adjustment for comorbid conditions, @entity5 stage, @entity5 histology, operation status and lifestyle factors, socioeconomic differences in survival persisted. CONCLUSIONS: Socioeconomic disparities in survival after @entity43 were to some extent, but not fully explained by differences in important prognostic factors, suggesting further investigations into this problem, however implying that socially less advantaged @entity43 @entity1 should receive attention during @entity5 treatment and rehabilitation.

title: Do stage of disease, comorbidity or access to treatment explain socioeconomic differences in survival after @entity43 ? - A cohort study among Danish XXXX diagnosed 2005-2010.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'early cancer', 'tumour']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: High school athletes in the United States sustain millions of injuries annually, approximately 10% of which are @entity174 . However, there is no clear estimate of the number of @entity1642 sustained by high school athletes annually despite reports that @entity1642 account for 0.7% to 20% of injuries seen in sports medicine clinics. This suggests a high utilization of resources for a potentially preventable injury. In addition, @entity1642 have been associated with low energy availability and @entity1277 in young athletes, highlighting the importance of early recognition and intervention. PURPOSE: To investigate @entity1642 rates and patterns in a large national sample of US high school athletes. STUDY DESIGN: Descriptive epidemiologic study. METHODS: Data from High School RIO (Reporting Information Online), a national @entity2587 surveillance study, were analyzed to describe rates and patterns of @entity1642 sustained from 2005-2006 through 2012-2013, across sports and by sex. RESULTS: From 2005-2006 through 2012-2013, a total of 51,773 injuries were sustained during 25,268,873 athlete-exposures, of which 389 (0.8%) were @entity1642 , resulting in an overall @entity1642 rate of 1.54 per 100,000 athlete-exposures. Rates per 100,000 athlete-exposures were highest in @entity1 ' cross country (10.62), @entity1 ' gymnastics (7.43), and @entity1 ' cross country (5.42). In sex-comparable sports, @entity1 sustained more @entity1642 (63.3%) than did @entity1 (36.7%) and had higher rates of @entity1642 (2.22 vs 1.27; rate ratio, 1.75; 95% CI, 1.38-2.23). The most commonly injured sites were the lower leg (40.3% of all @entity1642 ), foot (34.9%), and lower back/lumbar spine/pelvis (15.2%). Management was nonsurgical in 98.7% of the cases, and 65.3% of injuries resulted in >= 3 weeks of time loss, medical disqualification, or an end to the season before athletes could return to play. CONCLUSION: Although a @entity395 , @entity1642 cause considerable morbidity for high school athletes of both sexes. Future research should evaluate risks of @entity1642 to drive development of targeted prevention efforts.

title: Epidemiology of Stress XXXX Among US High School Athletes, 2005-2006 Through 2012-2013.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity2587 :: ('MESH:D001265', 'Disease') :: ['sports injury']

entities_list: @entity1277 :: ('MESH:D001068', 'Disease') :: ['disordered eating']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare injury']

entities_list: @entity1642 :: ('MESH:D015775', 'Disease') :: ['stress fracture injury', 'stress fractures', 'stress fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture Injuries']


abstract: OBJECTIVE: The aim of the study was to evaluate whether the presence of normal ovarian tissue adjacent to an @entity5 (the 'ovarian crescent sign') could assist in the preoperative differential diagnosis of @entity20428 . METHODS: This was a prospective observational study including 100 @entity1 with a preoperative diagnosis of an @entity4134 . Demographic and biochemical data were collected and all @entity1 underwent a detailed transvaginal ultrasound scan. @entity5 volume, morphological characteristics and Doppler features were recorded in each case. In addition, the tissue adjacent to the cyst was systematically examined for the presence of normal ovarian tissue. All the findings were compared to the final histological diagnosis. RESULTS: Sixty-seven (67%) of the cysts removed were benign, nine (9%) were borderline and 24 (24%) @entity1 had invasive @entity5 . Normal ovarian tissue was seen in 58/76 (76%) @entity1 with @entity3 , and in one @entity1 (4%) with an invasive @entity5 . In the absence of normal ovarian tissue, @entity43 was diagnosed with a sensitivity of 96% and specificity of 76%. CONCLUSION: The presence of normal ovarian tissue adjacent to an @entity42 is a useful morphological feature that may be used to help exclude an invasive @entity43 in @entity1 with @entity4134 detected on ultrasound scan.

title: The value of detection of normal ovarian tissue (the 'ovarian crescent sign') in the differential diagnosis of XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'ovarian malignancy']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesions', 'adnexal tumor', 'Tumor', 'malignancy']

entities_list: @entity42 :: ('MESH:D010048', 'Disease') :: ['ovarian cyst']

entities_list: @entity20428 :: ('MESH:D000291', 'Disease') :: ['adnexal lesions']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['non-invasive lesions']

entities_list: @entity4134 :: ('MESH:D000292', 'Disease') :: ['adnexal mass', 'adnexal masses']

answer: @entity4134 :: (MESH:D000292,Disease) :: ['adnexal masses']


abstract: PURPOSE: Despite theoretical advantages, no clear benefit was proven for initial application of robotic surgery for @entity356 so far. The aim of this analysis was to examine the role of robotic surgery regarding nodal dissection technically demanding areas compared to conventional laparoscopic surgery. METHODS: This analysis included 87 @entity1 who underwent robot-assisted distal gastrectomy (RADG) and 288 @entity1 who underwent laparoscopy-assisted distal gastrectomy (LADG) at the National @entity5 Center, Korea, between February 2009 and September 2011. Clinicopathologic data, surgery-related data, postoperative morbidity, and pathologic data for each nodal station were analyzed. RESULTS: Time to flatulence was 3.5      0.8  days for RADG and 3.8      0.8  days for LADG (P  =  0.01). Postoperative hospital stay was 6.7      1.0  days in RADG and 7.4      2.4  days in LADG (P  <  0.001).The number of dissected lymph nodes was 37.1      12.9 in the RADG group and 34.1      12.1 in the LADG group (P  =  0.044). In @entity1 undergoing D2 gastrectomy, the number of dissected lymph nodes in the N2 area was 16.3      7.7 for RADG and 13.2      5.3 for LADG (P  =  0.001). The number of dissected lymph nodes around the splenic artery area was 2.9      2.9 in RADG and 2.2      2.0 in LADG (P  =  0.04). Regarding @entity260 , there was no statistically significant difference [five @entity1 (5.7  %) in RADG and 26 @entity1 (9  %) in LADG) (P  =  0.330)]. CONCLUSION: RADG could provide an advantage over LADG in the dissection of the N2 area lymph nodes, especially around the splenic artery area.

title: Role of robot-assisted distal gastrectomy compared to laparoscopy-assisted distal gastrectomy in suprapancreatic nodal dissection for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: Patterns of intact parathyroid hormone (iPTH) elimination and subsequent recovery of parathyroid function were studied in seven @entity1 undergoing surgical removal of solitary hyperfunctioning @entity3243 . Using a sensitive two-site immunoradiometric assay, iPTH levels were measured pre, peri-, and postoperatively. Blood samples were taken at very early and at late stages, including 3, 6, 9, and 15 minutes and 48, 72, and 96 h after adenomectomy. A biexponential formula was calculated to fit the decreasing values of iPTH in all @entity1 . The @entity461 half-life in the early phase was 1.4 +/- 1.1 minutes (95% confidence limits). The @entity461 half-life in the second phase was 64.45 +/- 32.19 minutes (95% confidence limits). A third phase is represented by a slow, linear increase in plasma iPTH values as a result of the recovery of healthy suppressed parathyroid glands. The extrapolation to baseline of the later phase shows that the recovery of normal parathyroid function begins as soon as 240 minutes after adenomectomy and is independent of the decrease in @entity461 of adenomatous origin. All individual results were consistent with this model. Five @entity1 had iPTH values below 5 pg/ml, one had 15 pg/ml, and the last had 27 pg/ml 5 h after parathyroid adenomectomy. The recovery of the hormonal activity of the remaining glands occurred rapidly. By the postoperative hour 24 the mean serum iPTH concentration was 12.28 +/- 8.07 pg/ml. The intraoperative serum iPTH concentration offers a model to assess both recovery of hormonal secretion from functionally suppressed parathyroid glands and disappearance of parathyroid hormone.

title: Serum parathormone profile during surgical treatment of hyperfunctioning XXXX : a multicompartmental model.

entities_list: @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid adenoma']

answer: @entity3243 :: (MESH:D010282,Disease) :: ['parathyroid adenoma']


abstract: BACKGROUND: While @entity574 is an uncommon @entity74 and has various forms, its clinical features and outcome and its impact on @entity715 formation and the no-reflow phenomenon in the clinical setting of @entity583 ( @entity583 ) undergoing primary percutaneous coronary intervention (p-PCI) have not been discussed. The purpose of this study was to evaluate whether this @entity74 predisposes to a high burden of @entity715 formation, and subsequently leads to the no-reflow phenomenon and untoward clinical outcome in @entity1 with @entity583 undergoing p-PCI. METHODS AND RESULTS: In our hospital, emergency p-PCI was performed in 924 consecutive @entity1 with @entity583 between May 1993 and July 2001. Of these 924 @entity1 , 24 @entity1 (2.6%) who had an @entity1188 ( @entity1188 ) with @entity384 were retrospectively registered and constituted the @entity1 population of this study. Angiographic findings demonstrated that the @entity4122 type (defined as diffuse dilatation of 50% or more of the length of the @entity1188 ) was found most frequently (70%), followed by the fusiform type (20%; defined as a spindle-shaped dilatation in the @entity1188 ) and the saccular type (10%; defined as a localized spherical-shaped dilatation in the @entity1188 ). The right coronary artery was the most frequently involved vessel (54.2%), followed by the left anterior descending (25.0%) and the left circumflex arteries (20.8%). Coronary angiography revealed that all of these aneurysmal @entity1188 filled with heavy @entity715 (indicated as high-burden @entity715 formation). The no-reflow phenomenon (defined as <or=TIMI-2 flow) and distal embolization after p-PCI were found in 62.5 and 70.8% of the @entity1188 , respectively. The incidence of @entity1455 and the 30-day mortality rate were 25 and 8.3%, respectively. The survival rate was 90.9% (20/22) during a mean follow-up of 19 +/- 30 months. CONCLUSIONS: While @entity384 of an @entity1188 is an uncommon angiographic finding in the clinical setting of @entity583 , it is frequently associated with high-burden @entity715 formation and has a significantly lower incidence of successful reperfusion. However, the long-term survival of these @entity1 is excellent.

title: Clinical features and outcome of @entity574 in @entity1 with XXXX undergoing a primary percutaneous coronary intervention.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['aneurysmal dilatation']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct-related artery', 'IRA']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['anatomic disorder']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

entities_list: @entity574 :: ('MESH:D003323', 'Disease') :: ['coronary artery aneurysm']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: OBJECTIVE: To determine tissue solubilities of @entity10233 , @entity2614 , @entity4488 , and @entity1508 in @entity1707 and to evaluate the effects of freezing specimens on tissue solubility, SAMPLE POPULATION: Arterial blood samples and specimens of brain, heart, liver, kidney, muscle, and subcutaneous fat from 5 healthy female adult Chinese Meishan @entity1707 . PROCEDURE: Each tissue specimen was divided into 2 parts. One part was used to measure tissue-gas partition coefficients immediately after collection. The other part was frozen at -20 C for 6 days prior to determination of tissue-gas partition coefficients. Tissue-gas and blood-gas partition coefficients were measured by use of gas chromatography, and tissue-blood partition coefficients were calculated. Regression analysis was performed to determine whether fat-gas partition coefficients were correlated with lean tissue-gas partition coefficients. RESULTS: Tissue-gas and blood-gas partition coefficients of @entity1508 were greater than those of @entity4488 followed by coefficients of @entity2614 and @entity10233 . However, the order of anesthetic agents with the greatest to smallest tissue-blood partition coefficients was @entity2614 , @entity1508 , @entity4488 , and @entity10233 . Muscle-gas partition coefficients of @entity2614 and @entity4488 , liver-gas partition coefficients of @entity10233 and @entity1508 , and the kidney-gas partition coefficient of @entity4488 were significantly greater in frozen specimens, compared with fresh specimens. Lean tissue-gas partition coefficients of all 4 volatile anesthetics correlated directly with fat-gas partition coefficients. CONCLUSIONS AND CLINICAL RELEVANCE: The fat content of lean tissue is an important factor in determining the tissue solubility of volatile anesthetics. Freezing specimens before determination of tissue-gas partition coefficients may result in a false increase in tissue solubility.

title: Tissue solubility of four volatile anesthetics in fresh and frozen tissue specimens from XXXX .

entities_list: @entity1508 :: ('MESH:D006221', 'Chemical') :: ['halothane']

entities_list: @entity10233 :: ('MESH:C053562', 'Chemical') :: ['desflurane']

entities_list: @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']

entities_list: @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane']

answer: @entity1707 :: (9823,Species) :: ['swine']


abstract: An outbreak of @entity3069 . avium infection was diagnosed in one breed of @entity22036 ( @entity22036 f. domestica) in the Czech Republic. Nodular @entity75 were found in 42 (9.7%) pigeons of the 435 examined; histopathologic examination of livers with gross lesions of @entity4593 from 15 randomly selected pigeons revealed @entity32 typical for @entity17523 in all samples. Direct Ziehl-Neelsen (ZN) microscopy and conventional culture were performed for a total of 117 liver samples (42 pigeons with nodular lesions, 55 randomly selected pigeons without nodular lesions, and 20 randomly selected squabs). Acid-fast bacilli were observed in 19 (16.2%), and conventional culture yielded growth of M. a. avium in 40 (34.2%) liver samples. A triplex quantitative real-time PCR assay based on the IS901 detection system was performed successfully in 115 liver samples and revealed M. a. avium in 63 (54.8%) of them. @entity3069 a. avium was also detected in two squabs. Eight @entity95 ( @entity95 f. domestica) living in the breeding facility were also examined. @entity75 were only found in one adult male @entity95 . At necropsy, both direct ZN microscopy and culture gave negative results for mycobacteria in all examined @entity95 tissues. @entity3069 a. avium was diagnosed in a liver sample of one juvenile @entity95 using triplex qPCR, suggesting that M. a. avium infection can occur as early as juvenile animals.

title: Outbreak of XXXX . avium infection in one flock of @entity22036 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['granulomatous inflammation']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['granulomatous lesions', 'Pyogranulomatous lesions']

entities_list: @entity17523 :: ('MESH:D001715', 'Disease') :: ['avian mycobacteriosis']

entities_list: @entity95 :: ('9986', 'Species') :: ['domestic rabbits', 'rabbit', 'Oryctolagus cuniculus']

entities_list: @entity4593 :: ('MESH:D009165', 'Disease') :: ['mycobacteriosis']

entities_list: @entity3069 :: ('1764', 'Species') :: ['Mycobacterium', 'Mycobacterium avium subsp']

entities_list: @entity22036 :: ('8932', 'Species') :: ['Columba livia', 'domestic pigeons']

answer: @entity3069 :: (1764,Species) :: ['Mycobacterium avium subsp']


abstract: OBJECTIVE: To examine national trends of simple prostatectomy (SP) for @entity1067 ( @entity1067 ) focusing on perioperative outcomes and risk factors for complications. METHODS: The National Inpatient Sample (2002-2012) was utilized to identify @entity1 with @entity1067 undergoing SP. Analysis included demographics, hospital details, associated procedures and operative approach (open, robotic or laparoscopic). Outcomes included complications, length of stay (LOS), charges and mortality. Multivariate logistic regression was used to determine risk factors for perioperative complications. Linear regression was used to assess trends in the national annual utilization of SP. RESULTS: The study population included 35,171 @entity1 . Median LOS was 4 days (IQR 3-6). Cystolithotomy was performed concurrently in 6,041 @entity1 (17%). Overall complication rate was 28%, with @entity548 occurring most commonly. In total, 148 (0.4%) @entity1 experienced in-hospital mortality. On multivariate analysis, older age, black race and overall comorbidity were associated with greater risk of complications while use of a minimally invasive approach and concurrent cystolithotomy had a decreased risk. Over the study period, the national use of simple prostatectomy decreased, on average, by 145 cases per year (p=0.002). By 2012, 135/2580 procedures (5%) were performed using a minimally invasive approach. CONCLUSIONS: The nationwide utilization of SP for @entity1067 has decreased. Bleeding complications are common, but perioperative mortality is low. @entity1 who are older, black race or have multiple comorbidities are at higher risk of complications. Minimally invasive approaches, which are becoming increasingly utilized, may reduce perioperative morbidity.

title: National Trends of Simple Prostatectomy for XXXX with an Analysis of Risk Factors for Adverse Perioperative Outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity1067 :: (MESH:D011470,Disease) :: ['Benign Prostatic Hyperplasia']


abstract: This study aimed to prospectively evaluate the safety of endoscopic resection for early @entity5 in @entity355 ( @entity355 ) using the endoscopic cap resection (ER cap) technique. All resections performed between September 2000 and March 2006 with the ER-cap technique in @entity1 with @entity355 were included. Complications were classified 'acute' (during the procedure) or 'early' (< 48 h after the procedure). A total of 216 ER-cap procedures were performed in 121 @entity1 , of which 145 were performed with a standard hard cap and 71 with a large flexible cap. Specimens removed with the standard cap had a mean diameter of 20 mm (SD 5.0) versus 23 mm (SD 5.8) for the large cap (P < 0.001). Acute complications occurred in 51 procedures (24%), 49 bleedings and two perforations. All bleedings were effectively treated with hemostatic techniques and classified as mild complications. No @entity1 experienced a drop in hemoglobin levels or required blood transfusions or repeat interventions. The two perforations were classified as severe complications and treated conservatively. Three (1%) early complications, all bleedings, occurred and were effectively treated with endoscopic hemostatic techniques and classified as moderately severe complications. In manova the indication for the resection (high-grade @entity5 versus low-grade intraepithelial @entity5 or no @entity1141 ) was found to be significantly associated with an increased risk of @entity548 . Endoscopic cap resection in @entity355 is safe. Most complications become apparent immediately during the procedure and can be managed endoscopically. Bleeding after the endoscopic resection procedure and severe acute complications (i.e., perforations) are rare (2%).

title: Endoscopic cap resection for treatment of early Barrett's XXXX is safe: a prospective analysis of acute and early complications in 216 procedures.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ['BE', "Barrett's esophagus"]

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['acute bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['intraepithelial neoplasia or early cancer', 'neoplasia']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity5 :: (MESH:D009369,Disease) :: ['neoplasia']


abstract: PURPOSE: To evaluate the efficacy of fluorescent microsatellite analysis (MSA) for the serological diagnosis of @entity1606 ( @entity1606 ) of the urinary tract analyzing free @entity5 DNA in the serum of @entity5 @entity1 . EXPERIMENTAL DESIGN: We applied fluorescent MSA to detect serum-DNA alterations in @entity1 suffering from bladder and upper urinary tract @entity1606 and prospectively collected fresh @entity5 , peripheral blood, and serum specimens from 61 consecutive @entity1 to obtain the corresponding DNA. Fluorescent MSA was performed with a total of 17 polymorphic markers from the chromosomal regions 5q, 8p, 9p, 9q, 13q, 14q, 17p, 17q, and 20q in the 61 @entity5 @entity1 , as well as in 20 healthy controls. RESULTS: Molecular serological analysis led to @entity5 -specific diagnosis of @entity1606 in 80.3% (49 of 61) of cases. Four healthy controls displayed serum-DNA artifacts rendering a specificity of 80%. The highest frequency of serum-DNA alterations was detected for chromosomal region 8p with 36%. Chromosomes 5q, 9p, and 20q showed serum-DNA alterations in 18 to 21%. The identification of serum-DNA alterations was not statistically associated with underlying @entity5 stage (P = 0.29) but was more frequent in high-grade @entity5 (P = 0.08). CONCLUSIONS: MSA offers a highly sensitive method for serological diagnosis of @entity1606 . To optimize specificity, simultaneous analysis of @entity5 DNA is advised to rule out artifacts resembling @entity74 in MSA of serum DNA.

title: Molecular serological detection of DNA alterations in XXXX is highly sensitive and stage independent.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'local tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional cell carcinoma', 'TCC']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['allelic imbalance']

answer: @entity1606 :: (MESH:D002295,Disease) :: ['transitional cell carcinoma']


abstract: UNASSIGNED: @entity82 is a benign and slowly progressive @entity79 in which normal cancellous bone is replaced by immature woven bone and fibrous tissue. Precise excision of the lesion is crucial to restore function and aesthetics. We present our experience using surgical navigation technology for the recontouring of the faces of 8 @entity1 with maxillofacial @entity82 who were treated from 2012-2013, all of whom were thought suitable for surgical recontouring. Preoperative computed tomography (CT) scans were used to make a virtual plan based on the @entity1 's mirrored anatomy. During the operation we fixed a rigid digital reference frame to the @entity1 's forehead or mandible, depending on the site of the lesion. The @entity1 and the virtual image were matched through an individual recording technique. A pointing device was in constant use to find out whether the extent of resection was consistent with the preoperative design, and we assessed the surgical outcome by fusion of the preoperative planning and postoperative CT reconstruction images. The acquisition of the data sets was uncomplicated, and the use of surgical navigation improved the safety and the accuracy of the recontouring. There were no complications during 1-2 years follow up. Navigational guidance based on a virtual plan is safe and accurate, and is of value in the management of maxillofacial @entity82 .

title: Surgical management of maxillofacial XXXX under navigational guidance.

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['disorder of bone']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrous dysplasia', 'Fibrous dysplasia']

answer: @entity82 :: (MESH:D005355,Disease) :: ['fibrous dysplasia']


abstract: We fabricated a @entity505 nanotube (CNT)/adhesive @entity13768 (a @entity16549 ) composite-based dry electroencephalograph (EEG) electrode for capacitive measuring of EEG signals. As research related to brain-computer interface applications has advanced, the presence of hairs on a @entity1 's scalp has continued to present an obstacle to recorder EEG signals using dry electrodes. The CNT/a @entity16549 electrode developed here is elastic, highly conductive, self-adhesive, and capable of making conformal contact with and attaching to a hairy scalp. Onto the conductive disk, hundreds of conductive pillars coated with @entity14430 insulation layer were fabricated. @entity1129 was attached on the disk to transmit biosignals to the pillar. The top of disk was designed to be solderable, which enables the electrode to connect with a variety of commercial EEG acquisition systems. The mechanical and electrical characteristics of the electrode were tested, and the performances of the electrodes were evaluated by recording EEGs, including alpha rhythms, auditory-evoked potentials, and steady-state visually-evoked potentials. The results revealed that the electrode provided a high signal-to-noise ratio with good tolerance for motion. Almost no leakage current was observed. Although preamplifiers with ultrahigh input impedance have been essential for previous capacitive electrodes, the EEGs were recorded here by directly connecting a commercially available EEG acquisition system to the electrode to yield high-quality signals comparable to those obtained using conventional wet electrodes.

title: Self-Adhesive and Capacitive XXXX Nanotube-Based Electrode to Record Electroencephalograph Signals From the Hairy Scalp.

entities_list: @entity14430 :: ('MESH:C011055', 'Chemical') :: ['Parylene C']

entities_list: @entity13768 :: ('MESH:C013830', 'Chemical') :: ['polydimethylsiloxane']

entities_list: @entity1129 :: ('MESH:D001260', 'Disease') :: ['A CNT/aPDMS layer']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['Carbon']


abstract: We found previously that dietary soy protein, compared with casein, reduced plasma LDL @entity165 and increased HDL @entity165 concentrations in healthy @entity1 and @entity1 . However, there was considerable variation among individuals. The aim of this study was to characterize the lipoprotein responsiveness of individuals to examine whether different response patterns could be identified. Nine normolipemic @entity1 consumed 2 liquid-formula diets of identical composition except that the protein component was either soy protein or casein. After 1 mo of consuming each diet, the subjects' plasma HDL @entity165 (P < 0.01) and @entity1675 (P < 0.05) concentrations were increased by the soy-protein diet whereas the ratio of LDL @entity165 to HDL @entity165 was decreased (P < 0.01); total @entity165 , @entity1674 , LDL @entity165 , @entity755 and @entity3294 were insignificantly affected. In 5 individuals, however, soy protein reduced mean LDL @entity165 , LDL2 @entity165 , and LDL2 @entity755 concentrations by 26% and plasma @entity755 by 16%, whereas HDL @entity165 increased by 11%. In 3 other individuals, soy protein increased mean HDL @entity165 by 17% and plasma apo A-I by 12%, but did not lower LDL. In 1 subject, soy protein decreased LDL2 @entity165 by 11% and increased plasma @entity1674 by 40%, but neither HDL @entity165 nor apo A-I increased. We identified 3 types of lipemic responses to dietary soy protein involving a reduction in atherogenic LDL and increase in antiatherogenic HDL. In most subjects, the effects on both LDL and HDL were favorable, although fewer experienced either an increase in HDL or a decrease in LDL2.

title: Variable lipemic response to dietary soy protein in healthy, normolipemic XXXX .

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol']

entities_list: @entity1675 :: ('335', 'Gene') :: ['apolipoprotein (apo) A-I']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['men']