abstract: PURPOSE: To compare two published schedules of @entity900 plus @entity1487 ( @entity1487 ) infusion and radiation as either sequential or concomitant treatment for @entity137 and efficacy in @entity1 with unresectable @entity135 . @entity1 AND METHODS: This was a randomized trial between @entity900 100 mg/m2 over 15 minutes on day 1 plus @entity1487 1.0 g/m2 by continuous infusion on days 1 to 5, repeated every 3 weeks for three cycles, followed by 70 Gy of radiation in 7 to 8 weeks, versus @entity900 60 mg/m2 over 15 minutes on day 1 plus @entity1487 800 mg/m2 by continuous infusion on days 1 to 5 plus radiation 2 Gy on days 1 to 5, repeated every other week for seven cycles. Unresectable head and neck squamous @entity5 @entity1 not previously treated with radiation or chemotherapy and with a performance status of 0 to 2 were stratified by @entity5 ( @entity5 ) and node (N) groupings and performance status and randomized. RESULTS: Two hundred fifteen @entity1 were entered and 214 analyzed, 107 on each arm. After all treatment, overall response rates were different (P = .003), with similar complete response rates, but more partial responses and fewer @entity1 with no change or progression with concomitant treatment. Cox regression analysis for progression-free survival identified concomitant treatment (P = .003), Radiation Therapy Oncology Group (RTOG) stage III grouping (P < .0001), performance status (P = .0002), concomitant treatment (P = .003), and treating institution (P = .006) as significant. The sequential and concomitant treatments showed similar distant failure patterns (10% and 7%, respectively), but divergent regional failure rates (55% and 39%). Severe and worse toxic events were similar between the treatment programs, but radiation-induced @entity33 combined with @entity900 -induced water-losing @entity8 , in the concomitant arm only, demanded more supportive care. Survival duration was similar between the treatment arms, but significantly more @entity1 in the sequential arm died of their @entity5 (P = .011). CONCLUSION: Concomitant treatment offered improved disease control, predominantly of regional disease, but benefit was dependent on the experience of the treating institution. Translation of this benefit into improved survival is not yet evident, with an excess of @entity204 from other causes in the concomitant arm.

title: Randomized comparison of neoadjuvant @entity900 and XXXX infusion followed by radiation versus concomitant treatment in advanced @entity135 .

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'T', 'cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', 'fluorouracil']

answer: @entity1487 :: (MESH:D005472,Chemical) :: ['fluorouracil']


abstract: @entity674 ( @entity674 ) are the most common @entity361 of the gastro intestinal tract and express the @entity2467 proto-oncogene protein ( @entity2467 ). We report herein a case of a 58 years old male with upper @entity490 and @entity417 . Preoperative endoscopic and barium meal exams showed a @entity5 in the gastric fornix. Endoscopic biopsy revealed spindle-shaped cells with elongated nuclei specific of @entity674 . We performed a stapled resection of the gastric fornix associated with Hiss angle reconstruction. Postoperative histologic exam revealed the same spindle-shape cells characteristic of @entity674 with 2-5 mitosis/50HPF. Almost all of the cells showed immunoreactivity for @entity2467 , @entity2280 and a Ki-67 labeling index of 30%. Postoperative course was non eventful and after 3 month the @entity1 has no recurrence. CONCLUSIONS: @entity674 are rare @entity356 and are usually associated with @entity548 and @entity490 . The preoperative diagnosis is usually established by endoscopy with biopsy or endoscopic ultrasonography fine needle aspiration and barium meal exam. Only immunoreactivity is able to differentiate @entity674 from other @entity361 . Surgical resection is a safe and effective treatment. The chemotherapy with @entity669 kinases competitive inhibitors (e.g. @entity2213 ) is also recommended.

title: [Gastric XXXX . Case report].

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['submucosal tumor']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib mesylate']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumors']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['GIST', 'Gastrointestinal stromal tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['stromal tumor']


abstract: BACKGROUND: The success of robotic @entity453 ( @entity453 ) in recent years has led to the expansion of the procedure to @entity1 with more severe disease. Outcomes with these @entity1 have not yet been well characterized, and no reports on @entity453 performed in @entity1 with a preoperatively placed intraaortic balloon pump (IABP) are available. We present our initial experience with this @entity1 population. @entity1 AND METHODS: We evaluated 5 @entity1 with unstable @entity951 or @entity1002 requiring a preoperatively placed IABP who underwent @entity453 using the daVinci telemanipulation system. Procedures were performed either on the beating heart using an endostabilizer (n = 2) or on the arrested heart using remote access perfusion and @entity2333 (n = 3). The median @entity1 age was 67 years (range, 41-73 years), with a median preoperative ejection fraction of 43% (range, 26%-58%) and median EuroSCORE of 5 (range, 3-8). RESULTS: There were no major intraoperative technical issues. The median length of stay in the hospital and intensive care unit was 8 days (range, 5-13 days) and 66 hours (range, 41-142 hours), respectively. There were no intraoperative or 30-day mortalities. CONCLUSIONS: This early experience suggests that @entity453 is feasible in @entity1 with a preoperatively placed IABP. Both the beating heart and arrested heart versions can be used in this @entity1 population, further broadening the spectrum of applicability of this procedure.

title: Is an intraaortic balloon pump a contraindication to robotic XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic balloon endoocclusion']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['TECAB', 'totally endoscopic coronary artery bypass']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['impaired left ventricular function']

answer: @entity453 :: (MESH:D003324,Disease) :: ['totally endoscopic coronary artery bypass']


abstract: OBJECT: For the past 130 years, it has been believed that @entity101 -induced @entity1779 are the result of @entity397 of @entity397 of arteries that have degenerative changes. The majority of previous investigations have focused on autopsied brain. In this study, the authors attempted to verify the cause of @entity101 -induced @entity1779 by using surgical specimens of the penetrating arteries responsible for the @entity548 . METHODS: Between 1997 and 1999, the authors performed pathological studies in surgical specimens of lenticulostriate arteries that had been confirmed during microsurgery to be the cause of @entity101 -induced @entity548 of the putamen. @entity21962 were collected from 12 @entity1 . Fifteen of these arteries were verified as the pathological causes of @entity548 . They included six @entity4066 , six @entity397 with substantial degenerative changes, and three @entity397 with few degenerative changes. The pathological findings in the lenticulostriate artery dissections were similar to those of typical @entity4066 in major cerebral arteries. CONCLUSIONS: To the best of the authors' knowledge, @entity4066 of lenticulostriate arteries have not been identified as a cause of @entity101 -induced @entity1779 . When penetrating arteries are included as causative vessels, cerebral @entity4066 may be much more common than previously thought.

title: @entity4066 of penetrating cerebral arteries causing @entity101 -induced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'hemorrhages']

entities_list: @entity21962 :: ('MESH:D020144', 'Disease') :: ['Nineteen lenticulostriate arteries']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptures', 'microaneurysms or ruptures', 'arterial ruptures']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhage', 'cerebral hemorrhages']

entities_list: @entity4066 :: ('MESH:D020217', 'Disease') :: ['arterial dissections']

answer: @entity1779 :: (MESH:D002543,Disease) :: ['cerebral hemorrhage']


abstract: BIP1is a murine IgG antibody capable of enhancing the IgE binding to @entity56449 v 1, the major birch pollen allergen. We have previously generated a mimotope of BIP1, designated @entity56449 mim 1, from a constrained phage display peptide library. We demonstrated that oral immunization of BALB/c @entity19 with the @entity56449 mim 1 mimotope resulted in the induction of @entity56449 v 1-specific IgG. The aim of this study was to test the influence of such an oral immunization with @entity56449 mim 1 on a subsequent type I @entity56 response to @entity56449 v 1. Phages displaying @entity56449 mim 1 or control mimotopes, or PBS alone, were delivered to BALB/c @entity19 by intragastric gavages prior to systemic sensitization with recombinant @entity56449 v 1 and @entity12525 , an adjuvant inducing preferentially IgE antibody responses. Only @entity19 fed with @entity56449 mim 1-phages displayed substantially enhanced type I @entity56 skin reactivity to @entity56449 v 1, as compared to @entity19 pretreated with control mimotopes or PBS. A gastric digestion assay indicated that @entity56449 v 1 and its homologue from apple, Mal d 1, were degraded within seconds under physiological conditions. In contrast, phage-displayed mimotopes were resistant to digestion. Our data indicate that allergen mimics in the diet that resist digestion, can induce allergen specific IgG able to enhance an @entity56 response. We therefore conclude that sensitization via the oral route may represent a mechanism for aggravating @entity56 , probably leading to an earlier onset of symptoms even at lower allergen dosage.

title: Allergen mimotopes in food enhance @entity56 in XXXX .

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['type I allergic reactions', 'allergic']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: Exercise echocardiography was used to assess @entity741 after non-Q-wave acute @entity583 in 40 consecutive @entity1 . Resting @entity851 views and apical 4- and 2-chamber views were recorded, digitized, and stored. A maximal symptom-limited exercise test was performed within 21 days (mean 17.7 +/- 3) using a cycle ergometer with continuous monitoring and the echocardiogram was repeated in the same views. Resting and exercise echocardiograms were then compared. Coronary angiography was performed in all @entity1 within 21 days of exercise echocardiography. @entity850 in > or =50% of the lumen diameter was considered significant. Of the 40 @entity1 studied, 29 (72%) had continuing @entity951 and 11 (28%) had no @entity951 . Eighteen @entity1 (62%) with @entity951 developed @entity951 during exercise testing and 19 (65%) developed @entity308 . In @entity1 without @entity951 , 1 (9%) developed @entity951 (18%) developed @entity308 . The mean wall motion score index after exercise increased from 1.2 +/- 0.3 to 1.8 +/- 0.4 in @entity1 with continuing @entity951 (p <0.001) and from 1.2 +/- 0.3 to 1.4 +/- 0.3 in @entity1 without @entity951 (p = NS). Prolonged wall motion abnormalities lasting >20 minutes persisted in > or =1 segment in 27 of 29 @entity1 (93%) with @entity951 or in 2 of 1 1 @entity1 (18%) without @entity951 (p <0.001). @entity1 with continued @entity951 had predominantly 3-vessel @entity453 (22 of 29 [76%]) or 2-vessel disease (7 of 29 [24%]), and those without @entity951 (6 of 11 [55%]) or 2-vessel disease (4 of 11 [36%]). One @entity1 had 3-vessel disease. The duration of wall motion abnormality demonstrated a significant relation to 2- and 3-vessel @entity453 (p <0.001). Thus, @entity1 with non-Q-wave acute @entity583 had a high incidence of multivessel coronary disease not necessarily detected on routine exercise testing. There was also a significant incidence of prolonged wall motion abnormality.

title: Significance of prolonged left ventricular wall motion abnormalities after exercise echocardiography following non-Q-wave acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['parasternal long- and short-axis']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['ST-segment depression']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['postexercise angina and 2', 'angina had 1-vessel disease', 'angina']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['Stenosis']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: BACKGROUND: @entity3528 that persists after @entity8 ( @entity8 ), is the main cause of @entity2741 . Cinacalcet has been used to control @entity2741 in @entity8 @entity1 . OBJECTIVE: The aim of this study was to evaluate the effect of de novo cinacalcet in @entity8 @entity1 with @entity2741 and the evolution after its withdrawal. METHODS: This observational study included 41 @entity8 @entity1 (17 @entity1 ) with persistent @entity2741 (>6 months), defined as serum @entity460 (sCa) >= 10.5 mg/dL, and a mean age of 51.1    13.3 years with a functional allograft for >12 months. The time after surgery to begin cinacalcet was 33 months (range, 12.5-81.3). The initial dose of cinacalcet was 30 mg/d. In a subgroup of 14 @entity1 cinacalcet was stopped after 1 year. We studied the evolution of serum levels of @entity460 , @entity3151 , intact pathyroid hormone (iPTH), and serum @entity1011 . RESULTS: Calcemia normalized in all @entity1 (sCa <10.2 mg/dL). iPTH decreased (basal 267    212 pg/mL vs final: 219    160 pg/mL; P = ns) Serum @entity3151 increased (basal 2.85    0.48 mg/dL vs final 3.16    0.50 mg/dL; P = ns). Renal function remained stable (basal @entity1011 1.49    0.48 vs final 1.47    0.32 mg/dL; P = ns). After stopping cinacalcet, in group 1 calcemia persisted at normal levels in 50% (n = 7), but the drug had to be reintroduced in the other 50% after 10    7.9 months. No adverse events were documented. CONCLUSIONS: Cinacalcet is an effective alternative for the treatment of @entity2741 in @entity1 with persistent @entity2742 after @entity8 . Once the treatment is started, there is presently no invice to disclose to who tolerate its withdrawal or the time to do so.

title: Cinacalcet de novo in persistent @entity2741 after XXXX secondary to @entity2742 : long-term follow-up and effect of withdrawal.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['KT', 'kidney transplantation']

entities_list: @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia']

entities_list: @entity3528 :: ('MESH:D006962', 'Disease') :: ['Secondary hyperparathyroidism']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

entities_list: @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']

answer: @entity8 :: (MESH:D007674,Disease) :: ['kidney transplantation']


abstract: Vocal @entity912 is one of the frequently encountered complications after aortic surgery. However, reports of @entity3746 after aortic surgery have been limited. In a retrospective cohort study of @entity3746 after aortic surgery at a general hospital, we sought factors related to its development after aortic surgery to the descending thoracic aorta via left posterolateral thoracotomy. We reviewed data for a total of 69 @entity1 who, between 1989 and 1995, underwent aortic surgery to the descending thoracic aorta. We assessed factors associated with the development of @entity3746 and @entity260 . Postoperative @entity3746 appeared in 19 @entity1 . Multiple logistic regression analysis revealed two risk factors for @entity3746 : chronic dilatation of the aorta at the left subclavian artery (odds ratio = 8.67) and @entity254 proximal to the left subclavian artery (odds ratio = 17.7). The duration of mechanical ventilation was significantly prolonged for @entity1 with @entity3746 . Certain surgical factors associated with left subclavian artery increase the risk of @entity3746 after surgery on the descending thoracic aorta. Vocal @entity912 after aortic surgery did not increase aspiration @entity55 but was associated with @entity358 .

title: Vocal XXXX after surgery to the descending thoracic aorta via left posterolateral thoracotomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity3746 :: ('MESH:D014826', 'Disease') :: ['vocal cord paralysis']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['cord paralysis']

answer: @entity912 :: (MESH:D010243,Disease) :: ['cord paralysis']


abstract: The inhibition of the haematological alterations and prevention of @entity204 due to systemic @entity2021 after antigen challenge were investigated in @entity35 after various drug treatments. The i.v. injection of ovalbumin (250 micrograms/kg) into actively sensitized @entity35 induced marked @entity882 and haemoconcentration within 5 min and significant @entity491 within 30 min, lasting for 2 h after the challenge. Pretreatment with @entity31738 or @entity9691 (15-30 mg/kg i.p.) inhibited antigen-induced haemoconcentration, whereas @entity6849 (2-10 mg/kg i.p.) and @entity21327 (5-10 mg/kg p.o.), two platelet-activating factor (PAF) antagonists, interfered with @entity882 only. @entity24174 (1-20 mg/kg p.o.) dose dependently inhibited antigen-induced haemoconcentration and @entity882 but failed to @entity616 . @entity24174 also inhibited the @entity882 observed after the i.v. administration of PAF (4 micrograms/kg). Administration of ovalbumin at a dose of 1.5 mg/kg resulted in a lethal anaphylactic reaction in about 85% of the @entity35 . Pretreatment with @entity6849 (10 mg/kg i.p.), @entity31738 (30 mg/kg i.p.) or both increased the survival rate from 15 to 57, 68 and 87%, respectively. @entity24174 alone (20 mg/kg p.o.) completely blocked the lethal reaction. It was concluded that the ability of @entity24174 to antagonize @entity112 and PAF is important for its effectiveness against @entity2021 .

title: Interference of XXXX with @entity2021 induced by ovalbumin challenge in actively sensitized @entity35 .

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity24174 :: ('MESH:C020976', 'Chemical') :: ['Azelastine', 'azelastine']

entities_list: @entity31738 :: ('MESH:D008468', 'Chemical') :: ['meclizine']

entities_list: @entity9691 :: ('MESH:D016593', 'Chemical') :: ['terfenadine']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['block leukocytosis']

entities_list: @entity2021 :: ('MESH:D000707', 'Disease') :: ['anaphylaxis', 'anaphylactic shock']

answer: @entity24174 :: (MESH:C020976,Chemical) :: ['azelastine']


abstract: The polygenic nature of oral tolerance regulation was elucidated by the method of bidirectional selective breeding of @entity19 strains for @entity1668 ( @entity1668 ) and resistance (TR) starting from a genetically heterogeneous population achieved by the equilibrated intercrossing of eight inbred @entity19 strains (A/J, @entity7840 /2J, P/J, SWR/J, SJL/J, CBA/J, BALB/cJ and C57BL/6J). Seven days after intragastric administration of 5 mg OVA or BSA, @entity19 were intraperitoneally immunized with 100 microg of the corresponding antigen. The individual antibody titres were measured by haemagglutination. The phenotypes at the highest and lowest extremes were selected for assortative mating, avoiding consanguinity. The second litter of each mating couple was intraperitoneally immunized only to evaluate the immunocompetence of the corresponding generation and to ascertain the non-selection of non-responder @entity19 . A normal distribution of agglutinin titres ranging from 4 to 14 log2 was observed in the F0 population. In the F12 generation, TR and @entity1668 strains showed highly significant differences for agglutinin titres (TR=15.06+/-1.80 and @entity1668 =8.35+/-2.44), and IgG responses by ELISA. Up to the F12 generation, the mean realized heritability was 0.14+/-0.02. The response to the selection was 0.43 log2 and the selection differential 3.10 log2/generation. A provisional estimation indicated that oral tolerance may be influenced by eight or nine independent loci.

title: Genetics of immunological tolerance: I. Bidirectional selective breeding of XXXX for oral tolerance.

entities_list: @entity1668 :: ('MESH:D004198', 'Disease') :: ['TS', 'tolerance susceptibility']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: OBJECTIVE: To investigate the function of preserved ovaries following radical hysterectomy in premenopausal @entity1 with @entity2622 and to attempt to identify clinical factors influencing ovarian function. STUDY DESIGN: Between 1991 and 1998, 33 premenopausal @entity1 with International Federation of Gynecology and Obstetrics stage IB and II cervical @entity5 underwent @entity43 , including lateral ovarian transposition in 20 @entity1 . In 12 cases of @entity957 with deep stromal invasion or a suspicious, positive node, neoadjuvant chemotherapy was performed. Postoperative whole pelvic radiotherapy was administered to 11 @entity1 . Ovarian function was evaluated by serum FSH level during the follow-up period, 12 months to 9 years. RESULTS: Fifteen of 33 @entity1 became climacteric after treatment. Ten of 12 @entity1 over 40 years old became climacteric, as did 5 of 21 under 39 (P = .0013). Using multiple regression analysis, a significant correlation between @entity2670 and age (under 40) was observed (P = .0286). No ovarian recurrence or symptomatic @entity42 was observed in preserved ovaries during the study period. CONCLUSION: Ovarian preservation is safe in @entity1 under 40 years old undergoing radical hysterectomy even if they received additional treatment, such as neoadjuvant chemotherapy or postoperative radiotherapy with ovarian transposition.

title: Ovarian function after @entity43 for cervical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['radical hysterectomy with ovarian preservation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma']

entities_list: @entity42 :: ('MESH:D010048', 'Disease') :: ['ovarian cyst']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian dysfunction']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: @entity1822 ( @entity1822 ) account for 10-20% of all soft tissue @entity242 . We analyzed 10 primary, 5 metastatic, and 2 recurrent extrauterine @entity1822 . Genomic imbalances were detected in 15 out of the 17 @entity5 . The most common regions of loss were 13q (59%, 10 of 17), 10q (59%, 10 of 17), 2q (35%, 6 of 17), and 16q (29%, 5 of 17). The most common region of gain was 5p (35%, 6 of 17). High-level gain of DNA copy number was detected in 6p and 17p. @entity393 suppressor genes or the activation of oncogenes (or both of these factors) resulting from these copy number changes might play an important role in the development of extrauterine @entity1822 . Large @entity5 and @entity5 with @entity3 showed 10q deletions. Gain of 5p was detected only in G3 @entity5 . These findings are consistent with our earlier study on uterine @entity1822 and indicate that loss of 10q and gain of 5p are associated with an @entity146 . A larger series of cases is needed to confirm these results.

title: Loss of DNA copy number of 10q is associated with XXXX : a comparative genomic hybridization study.

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior of LMS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['Leiomyosarcomas', 'LMS']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['Loss of function of tumor']

answer: @entity146 :: (MESH:D001523,Disease) :: ['aggressive behavior of leiomyosarcomas']


abstract: BACKGROUND: Repair of total @entity1700 (TAPVD) in neonates remains a challenge. It is associated with a high mortality. We aimed at determining a method for risk stratification of this group of @entity1 . METHODS: From 1994 to 2008, 54 @entity1 underwent simple TAPVD operations during the first month of life. Mean pulmonary arterial pressure ( @entity2786 ), mean systemic arterial pressure (MAP), systolic blood pressure, diastolic blood pressure, central venous pressure, and left atrial pressure were recorded in 44 of the 54 @entity1 for the first 36 hours postoperatively. The remaining 10 @entity1 were excluded because data from invasive pressure monitoring were not available. RESULTS: There were overall 8 deaths (18.2%, 8/44), including 4 (9%, 4/44) early deaths, and 5 reoperations (11.4%, 5/44). The mean @entity2786 was 23.1    6.4 mm Hg, the mean MAP was 50.3    5 mm Hg, and the @entity2786 -to MAP-ratio ( @entity2786 /MAP) was 0.80    0.36. By multivariable logistic analysis, the risk factors for mortality were a higher @entity2786 /MAP (p = 0.037) and lower operative weight (p = 0.02). All deaths had either a @entity2786 /MAP of greater than 0.80 or an operative weight of less than 2.5 kg. Hemodynamic index ( @entity2786 /MAP divided by operative weight) was predictive of mortality (p = 0.007). Furthermore, the hemodynamic index (p = 0.003) predicted prolonged length of stay in the intensive care unit by regression analysis. CONCLUSIONS: The hemodynamic index ( @entity2786 /MAP/weight) >= 0.25 in the first 36 hours after TAPVD repair in neonates is predictive of mortality. A higher index predicted longer stay in the intensive care unit. This hemodynamic index may be a useful adjunct for risk stratification in neonates undergoing TAPVD repair.

title: Hemodynamic index for risk stratification after neonatal total XXXX repair.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1700 :: ('MESH:D012587', 'Disease') :: ['anomalous pulmonary venous drainage']

answer: @entity1700 :: (MESH:D012587,Disease) :: ['anomalous pulmonary venous drainage']


abstract: PURPOSE: To evaluated the effect of the @entity31917 (GA), one of the effective components of Garcinia, in combination with a new multi-targeted oral medication, @entity2240 (SU) on @entity703 cell proliferation in vitro and on @entity5 growth in vivo. METHODS: After treatment with GA or SU, either alone or in combination, @entity98 and FACS analysis were used to examine cell viability and cycle distribution of the @entity703 cell lines 786-0 and Caki-1. Western blotting was employed to examine the expression of proteins related to the cell cycle and vascular formation. Furthermore, a xenograft model was applied to study the antitumor efficacy of SU or GA alone or in combination, with immunohistochemistry to detect expression of proteins related to xenograft growth and angiogenesis. Western blotting was used to examine NF-?B signaling pathway elements in xenografts. RESULTS: Treatment of 786-0 and @entity1 cells with GA or SU resulted in decreased @entity5 cell proliferation, especially with joint use. Cells accumulated more strongly in the sub-G1 phase after joint treatment with GA and SU than treatment of GA and SU alone. Western blotting arrays showed 1 protein significantly upregulated, 2 proteins downregulated, and 2 proteins unchanged. Moreover, combined use of GA and SU inhibited the growth and angiogenesis of xenografts generated from Caki-1 significantly. Immunohistochemistry arrays showed downregulation of the expression of proteins promoting xenograft growth and angiogenesis, and Western blotting showed inhibition of the NF-?B signaling pathway after treatment by GA alone and in combination with SU in xenografts. CONCLUSIONS: Our results show that the joint use of GA and SU can provide greater antitumor efficacy compared to either drug alone and thus may offer a new treatment strategy for @entity1358 .

title: XXXX with @entity31917 in combination with @entity2240 in vitro and in vivo.

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib']

entities_list: @entity31917 :: ('MESH:C052659', 'Chemical') :: ['gambogic acid']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal carcinoma']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['Targeting renal cell carcinoma']


abstract: BACKGROUND: The roles of age, length of service and job in various work-related @entity130 are unknown and deserve investigations among female workers. This study assessed their roles in the occurrence of injury. METHODS: Three-year prospective study of all 22,952 permanently employed @entity1 at the French national railway company: 63,620 @entity1 -years, 756 @entity130 with working days lost, coded using the company's injury classification derived from that of the French health insurance scheme. We investigated the incidence of four types of injury: fall on same level, fall to lower level, materials/equipment/objects handling, and other @entity130 . Data were analyzed using negative binomial regression. RESULTS: Workers aged <25 were subject to a higher risk for all types of @entity130 . Older workers (45-55 years) were subject to a higher injury risk for fall on same level and fall to lower level. For fall on same level as for fall to lower level the relative risk decreased steadily with increasing length of service with the company, from 1.60 for 1 year to 0.50-0.60 for >= 30 years. For @entity130 due to materials/equipment/objects handling the relative risk decreased from 1.05 for one year to 0.49 for 5-9 years, and then increased to about 1.50 for 20-29 years and >= 30 years. CONCLUSIONS: Younger and shorter lengths of service were at risk for various types of @entity130 . Higher length of service was at risk for injury due to materials/equipment/objects handling. Preventive measures should consider the respective risks associated with age, years of employment and job.

title: Roles of age, length of service and job in work-related injury: a prospective study of 63,620 XXXX -years in female workers.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'person']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'injury types']

answer: @entity1 :: (9606,Species) :: ['person']


abstract: PURPOSE: To assess the clinical activity and @entity137 of a combination chemotherapy regimen of @entity11730 and @entity900 in @entity1 with recurrent and/or metastatic @entity213 ( @entity213 ) in a retrospective study. METHODS: A total of 49 @entity1 were treated in an outpatient setting with @entity11730 80 mg/m(2) on days 1-14 and with @entity900 70 mg/m(2) on day 1 every 3 weeks for a maximum of six cycles as a first-line palliative chemotherapy. @entity1 who achieved complete response (CR), partial response (PR) or @entity66 ( @entity66 ) after six cycles received @entity11730 monotherapy as a maintenance therapy. RESULTS: The median @entity1 age was 55 years (range 33-79), 89.8 % were male, and the Eastern Cooperative Oncology Group performance status distribution was 0/1/2 (20.4 %/73.5 %/6.1 %). Of the 43 evaluable @entity1 , 2 (4.1 %) achieved CR and 20 (40.8 %) had a PR, for an overall response rate of 44.9 %. Thirteen @entity1 (26.6 %) had @entity66 . The median number of chemotherapy treatments was 4 (range 1-18). Nine @entity1 received maintenance @entity11730 monotherapy after six cycles of combination chemotherapy. With a mean 10.5 months (range 1.3-25.1) of follow-up, the median progression-free and overall survival were 4.5 (95 % CI, 3.7-5.3 months) and 10.8 months (95 % CI, 5.9-15.6 months), respectively. The main grade 3-4 @entity137 were @entity1398 (37 %), @entity417 (16 %) and @entity425 (8 %). Other @entity137 , including @entity390 / @entity391 , @entity33 and @entity16 , were mostly grade 1-2 and easily manageable. CONCLUSIONS: The combination of @entity11730 / @entity900 therapy had a favorable efficacy with manageable @entity137 as a first-line chemotherapy regimen for advanced @entity213 @entity1 .

title: The efficacy and @entity137 of XXXX and @entity900 as first-line chemotherapy in recurrent or metastatic @entity213 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['SD', 'stable disease']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['general weakness']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

answer: @entity11730 :: (5707,Gene) :: ['S-1']


abstract: OBJECTIVES: @entity2 rates vary considerably among U.S. racial/ethnic groups. We quantitatively analyzed the extent to which these differences can be attributed to differential patterns of smoking. METHODS: We utilized survey data from the U.S. Census to estimate smoking patterns in the following racial/ethnic groups: non-Hispanic whites, @entity7864 , Hispanics, Asian/Pacific Islanders and American Indians. We used several dose-response models of @entity2 to predict relative @entity2 rates in these groups based on reported smoking patterns, specifically, on smoking status (current, former, never), cigarettes per day, age started, and age quit (for former smokers). Predicted rates were compared to observed population rates for these groups. RESULTS: Black @entity1 had slightly lower predicted @entity2 rates than white @entity1 , but had 35-47% higher observed rates. Hispanic @entity1 had predicted rates about 25% lower than whites but observed rates 50% lower than whites; predicted rates for Hispanic @entity1 were 50% lower than whites compared to observed rates that were 60-70% lower. For Asian/Pacific Islanders, predicted and observed rates relative to whites were comparable. Predicted rates for American Indians were slightly higher than whites while observed rates were about 40% lower. CONCLUSION: Differences in smoking largely explain @entity2 rates in Asian/Pacific Islanders relative to whites and partially explain lower rates in Hispanics compared to whites. Increased rates in black @entity1 and decreased rates in American Indians are not explained by differences in smoking.

title: Racial and ethnic differences in XXXX incidence: how much is explained by differences in smoking patterns? (United States).

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lower lung cancer', 'lung cancer', 'smoking and lung cancer']

entities_list: @entity7864 :: ('MESH:D055008', 'Disease') :: ['non-Hispanic blacks']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: CASE DESCRIPTION: A 19-month-old 536.4-kg (1,180-lb) Brown Swiss heifer was referred for evaluation of a firm swelling over the distal aspect of the right metatarsal region and chronic @entity1273 in the right hind limb. CLINICAL FINDINGS: Examination of radiographs of the right metatarsophalangeal joints revealed an expansile, smoothly marginated, @entity8 within the distal metaphysis of the metatarsal III and IV bone. Differential diagnoses included @entity79 , @entity2001 , @entity439 @entity2001 , @entity5 , @entity4034 , and @entity2331 . Aerobic microbial culture of the aspirate yielded moderate growth of branching, gram-positive, rod-shaped bacteria, which were presumptively identified as Nocardia spp. The isolate was subsequently identified as @entity7180 by 16S rRNA gene sequence analysis. TREATMENT AND OUTCOME: The lesion was surgically debrided, lavaged, and bandaged. Exercise was restricted, and systemic and local administration of antimicrobials was instituted. After a communication between the @entity2720 was iatrogenically created, the extralabel use of @entity581 was initiated. The heifer had noticeable clinical improvement within 2 weeks after initial evaluation and reportedly had no evidence of @entity1273 and minimal external blemishes 3 months after the second evaluation. CLINICAL RELEVANCE: To our knowledge, this is the first report on the diagnosis and management of a @entity79 attributable to N arthritidis infection in @entity291 . Complications encountered during treatment and the decision to engage in extralabel use of antimicrobial agents in the heifer described here may serve as a guide for food animal practitioners faced with the treatment of valuable @entity291 .

title: XXXX in the distal metaphysis of the metatarsal III and IV bone of a heifer.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['cyst-like lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity7180 :: ('MESH:D009617', 'Disease') :: ['Nocardia arthritidis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone abscess', 'long-bone abscess']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['metabolic bone disease']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysmal']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['abscess and the metatarsophalangeal joints']

answer: @entity7180 :: (MESH:D009617,Disease) :: ['Nocardia arthritidis infection']


abstract: Transcription of the carAB operon encoding the unique @entity12116 synthase of @entity526 reflects the dual function of @entity12116 in the biosynthesis of @entity369 and @entity17450 . The tandem pair of promoters is regulated by various mechanisms depending on the needs of both pathways and the maintenance of a @entity7391 / @entity10043 @entity377 balance. Here we focus on the linker regions that impose the distribution of target sites for DNA-binding proteins involved in @entity7391 - and @entity10043 -specific repression of the upstream promoter P1. We introduced deletions and insertions, and combinations thereof, in four linkers connecting the binding sites for integration host factor (IHF), PepA, PurR, and RNA polymerase and studied the importance of phasing and spacing of the targets and the importance of the @entity377 sequence of the linkers. The two PepA binding sites must be properly aligned and separated with respect to each other and to the promoter for both @entity7391 - and @entity10043 -mediated repression. Similarly, the phasing and spacing of the IHF and PEPA2 sites are strictly constrained but only for @entity7391 -specific repression. The IHF target is even dispensable for @entity10043 -mediated regulation. Thus, a correct localization of PepA within the higher-order nucleoprotein complex is a prerequisite for the establishment of @entity7391 -mediated repression and for the coupling between @entity10043 - and @entity7391 -dependent regulation. Our data also suggest the existence of a novel cis-acting @entity7391 -specific regulatory target located around position -60. Finally, the analysis of a P1 derivative devoid of its control region has led to a reappraisal of the effect of excess @entity5536 on P1 and has revealed that P1 has no need for a UP element.

title: Mutational analysis of intervening sequences connecting the binding sites for integration host factor, PepA, PurR, and RNA polymerase in the control region of the @entity526 carAB operon, encoding XXXX synthase.

entities_list: @entity12116 :: ('MESH:D002221', 'Chemical') :: ['carbamoylphosphate']

entities_list: @entity17450 :: ('MESH:D011742', 'Chemical') :: ['pyrimidine nucleotides']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

entities_list: @entity7391 :: ('MESH:C030986', 'Chemical') :: ['pyrimidine']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity12116 :: (MESH:D002221,Chemical) :: ['carbamoylphosphate']


abstract: BACKGROUND: @entity56 to @entity1542 have been described following ingestion of fish and were thought to be possible even if seafood is frozen or well-cooked. OBJECTIVE: This study aimed to confirm, by challenge test, that dead A. simplex larvae are not able to trigger @entity56 in @entity1 with proven @entity56 to this parasite. METHODS: Simple-blind, placebo-controlled, oral challenge tests with frozen A. simplex larvae were performed in 12 @entity1 who had suffered severe anaphylactic reactions after ingestion of seafood and diagnosed of @entity56 by skin prick test and specific IgE. If no reaction appeared, they were told to eat frozen seafood. 63 @entity1 who had suffered @entity110 or @entity110 / @entity113 by @entity56 to A. simplex were also advised to eat frozen seafood. All of them were reevaluated 6 months later. RESULTS: All @entity1 tolerated the dead larvae challenge test. After eating previously frozen seafood at least two times per week, all @entity1 , including those who had suffered anaphylactic reactions and those who had only presented cutaneous manifestations, remained asymptomatic. CONCLUSIONS: @entity1542 - @entity56 @entity1 tolerate ingestion of dead larvae. It is probable that these @entity1 can eat frozen fish and that a seafood-free diet is not necessary.

title: Freezing protects against allergy to XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1542 :: ('6269', 'Species') :: ['Anisakis simplex']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['A. simplex hypersensitivity', 'demonstratred hypersensitivity', 'Allergic reactions', 'allergic', 'allergic reactions', 'hypersensitivity']

entities_list: @entity113 :: ('MESH:D000799', 'Disease') :: ['angioedema']

entities_list: @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']

answer: @entity1542 :: (6269,Species) :: ['Anisakis simplex']


abstract: PURPOSE: Waldenstr  m's @entity8057 ( @entity8057 ) is a low-grade @entity706 in which @entity2225 is usually expressed on @entity5 cells. There is evidence that @entity1 with @entity8057 may benefit from treatment with the anti- @entity2225 monoclonal antibody rituximab. We performed a prospective phase II study to clearly define the activity of rituximab in @entity1 with this disease. @entity1 AND METHODS: Twenty-seven @entity1 with @entity8057 were treated with rituximab 375 mg/m(2) intravenously (IV) for 4 weeks. Three months after completion of rituximab, @entity1 without evidence of progressive disease received repeat 4-week courses of this agent. All @entity1 were symptomatic, their median age was 72 years, and 15 @entity1 were previously untreated. RESULTS: Twelve @entity1 (44%; 95% confidence interval, 25.5% to 64.7%) achieved a partial response after treatment with rituximab. Median time to response was 3.3 months (range, 2.2 to 7.1 months). Responses occurred in six (40%) of 15 previously untreated @entity1 and in six (50%) of 12 pretreated @entity1 . @entity1 with a serum immunoglobulin M less than 40 g/L had a significantly higher response rate. The median time to progression for all @entity1 was 16 months, and with a median follow-up of 15.7 months, nine of 12 responding @entity1 remain free of progression. Treatment with rituximab was well tolerated, with approximately one fourth of @entity1 experiencing some mild form of infusion-related @entity137 , usually fever and chills. CONCLUSION: Our prospective data indicate that rituximab is well tolerated and active in @entity1 with @entity8057 . Previously untreated and pretreated @entity1 seem to benefit equally. Repeat 4-week courses of rituximab may prolong the duration of response of the disease, but this observation requires confirmation in prospective, randomized trials. Furthermore, studies that will combine rituximab with chemotherapy may be relevant.

title: Treatment of Waldenstr  m's XXXX with rituximab.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoplasmacytic lymphoma']

entities_list: @entity8057 :: ('MESH:D008258', 'Disease') :: ['WM', 'macroglobulinemia']

answer: @entity8057 :: (MESH:D008258,Disease) :: ['macroglobulinemia']


abstract: Monoclonal antibodies that bound to the external domain of the @entity95 @entity11030 -related protein ( @entity8993 ) were taken into @entity95 fibroblasts by receptor-mediated endocytosis. Uptake occurred in fibroblasts from Watanabe-heritable hyperlipidemic @entity95 , which lack low density lipoprotein receptors, as well as in normal @entity95 fibroblasts. The fate of the internalized antibodies differed, depending on the domain of @entity8993 that was recognized. @entity8993 is synthesized as a single polypeptide chain that is cleaved to form a heterodimer of two noncovalently bound proteins, 1) a 515-kDa subunit that contains the binding domain, and 2) an 85-kDa subunit that contains the membrane-spanning region and cytoplasmic tail. A monoclonal antibody directed against the 515-kDa subunit (anti- @entity8993 515) rapidly dissociated from @entity8993 at pH 5.2. After uptake by cells this antibody dissociated from the receptor and was degraded in lysosomes. A second antibody directed against the external portion of the 85-kDa subunit (anti- @entity8993 85) failed to dissociate at acid pH. After uptake by cells this antibody was not degraded, but instead was released from the cells in an acid-precipitable form. When administered intravenously to @entity95 , both 125I-labeled antibodies were rapidly cleared from the circulation, 75-95% of the uptake occurring in the liver. The anti- @entity8993 515 antibody was degraded and acid-soluble products appeared in the plasma. No significant acid-soluble products appeared when the anti- @entity8993 -85 antibody was infused. We conclude that @entity8993 can carry out receptor-mediated endocytosis and that its ligand-binding domain, like the similar domain of the @entity11030 , undergoes an acid-dependent conformational change that ejects ligands within the endosome. We also conclude that in the body this endocytotic function is expressed primarily in the liver. Both of these conclusions lend support to the hypothesis that @entity8993 may function in @entity1 and animals as a receptor for apolipoprotein E-enriched lipoproteins, such as chylomicron remnants.

title: XXXX -related protein mediates endocytosis of monoclonal antibodies in cultured cells and @entity95 liver.

entities_list: @entity11030 :: ('100009086(Tax:9986)', 'Gene') :: ['low density lipoprotein receptor']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

answer: @entity11030 :: (100009086(Tax:9986),Gene) :: ['Low density lipoprotein receptor']


abstract: Up to 50% of the over 140,000 new @entity14 @entity1 will present with synchronous @entity14 and liver @entity3 . Surgical management of @entity1 with resectable synchronous @entity99 is complex and must consider multiple factors, including the presence of symptoms, location of @entity5 and liver metastases, extent of @entity5 (both primary and metastatic), @entity1 performance status, and underlying comorbidities. Possible approaches to this select group of @entity1 have included a synchronous resection of the colorectal primary and the hepatic metastases or a staged resection approach. The available literature regarding the safety of synchronous versus staged approaches confirms that a simultaneous resection may be performed in selected @entity1 with acceptable morbidity and mortality. Perioperative mortality when minor hepatectomies are combined with colorectal resection is consistently  <=5%. Perioperative morbidity varies considerably following both synchronous and staged resections. However, the bulk of the existing literature confirms that simultaneous resections are both feasible and safe when hepatic resections are limited to <3 segments. Data regarding the oncologic outcomes following synchronous versus staged resections for Stage IV @entity14 are more limited than those available regarding postoperative morbidity and mortality. The available data suggest equivalent overall and disease-free survival regardless of timing of resection. Experience with minimally invasive combined colorectal and hepatic resections is extremely limited to date and consists exclusively of small single center series. The potential benefits of a minimally invasive approach will await the results of larger studies.

title: Synchronous resection of colorectal primary and hepatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['colorectal hepatic metastasis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: The effect of preoperative chemotherapy in the treatment of @entity418 is difficult to assess because of the inadequacies of clinical staging. Endoscopic esophageal ultrasound (EUS) has been shown to be accurate in the clinical determination of depth of @entity5 invasion (T) and regional lymph node status (N). Therefore, EUS may be useful in assessing the effect of preoperative chemotherapy in the treatment of @entity418 . Eleven @entity1 with operable @entity7145 or esophagogastric junction underwent staging by EUS before treatment. This was followed by two courses (10 @entity1 ) or one course (1 @entity1 ) of chemotherapy: @entity2879 , 120 mg/m2 for 3 days; @entity632 , 20 mg/m2; and @entity900 , 100 mg/m2. Restaging by EUS was done after treatment. Ten @entity1 then underwent resection of the @entity5 with lymphadenectomy. One @entity1 was found to have metastatic disease at thoracotomy and did not undergo resection. However, tissue sampling was adequate for the determination of pathological stage. Independent pathological determinations of T and N were then obtained. On completion of chemotherapy, 9 @entity1 (82%) had relief or reduction of preoperative symptoms, and 9 @entity1 (82%) had either no evidence of @entity5 or reduction of @entity5 size by endoscopy. Despite this clinical and endoscopic response, no @entity1 had EUS-documented and pathology-confirmed reduction of T. However, 2 @entity1 had EUS-documented and pathology-confirmed progression of N. The accuracy of @entity2910 was 82% and of N, 73%.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX : esophageal ultrasound assessment of preoperative chemotherapy.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin hydrochloride']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['EUS in the determination of T']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal carcinoma']

entities_list: @entity7145 :: ('MESH:C562730', 'Disease') :: ['adenocarcinoma of the esophagus']

answer: @entity418 :: (MESH:D004938,Disease) :: ['Esophageal carcinoma']


abstract: BACKGROUND: @entity1005 ( @entity1005 ) may occur in @entity1 after exposure to a life-threatening illness. About one out of six @entity1 develop clinically relevant levels of @entity1005 symptoms after @entity583 ( @entity583 ). Symptoms of @entity1005 are associated with impaired quality of life and increase the risk of recurrent @entity65 . The main hypothesis of the @entity583 -SPRINT study is that trauma-focused psychological counseling is more effective than non-trauma focused counseling in preventing posttraumatic stress after @entity583 . METHODS/DESIGN: The study is a single-center, randomized controlled psychological trial with two active intervention arms. The sample consists of 426 @entity1 aged 18 years or older who are at 'high risk' to develop clinically relevant posttraumatic stress symptoms. 'High risk' @entity1 are identified with three single-item questions with a numeric rating scale (0 to 10) asking about ' @entity158 during @entity583 ', 'fear of dying until admission' and/or 'worrying and feeling helpless when being told about having @entity583 '. Exclusion criteria are emergency heart surgery, severe comorbidities, current severe @entity308 , @entity73 and suicidal ideation. @entity1 will be randomly allocated to a single 45-minute counseling session targeting either specific @entity583 -triggered traumatic reactions (that is, the verum intervention) or the general role of psychosocial stress in @entity301 (that is, the control intervention). The session will take place in the coronary care unit within 48 hours, by the bedside, after @entity1 have reached stable circulatory conditions. Each @entity1 will additionally receive an illustrated information booklet as study material. Sociodemographic factors, psychosocial and medical data, and cardiometabolic risk factors will be assessed during hospitalization. The primary outcome is the interviewer-rated posttraumatic stress level at three-month follow-up, which is hypothesized to be at least 20% lower in the verum group than in the control group using the t-test. Secondary outcomes are posttraumatic stress levels at 12-month follow-up, and psychosocial functioning and cardiometabolic risk factors at both follow-up assessments. DISCUSSION: If the verum intervention proves to be effective, the study will be the first to show that a brief trauma-focused psychological intervention delivered within a somatic health care setting can reduce the incidence of posttraumatic stress in @entity583 @entity1 . TRIAL REGISTRATION: ClinicalTrials.gov: NCT01781247.

title: XXXX - Stress PRevention INTervention ( @entity583 -SPRINT) to reduce the incidence of posttraumatic stress after @entity583 through trauma-focused psychological counseling: study protocol for a randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['disorientation, cognitive impairment']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['Posttraumatic Stress Disorder', 'PTSD']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute MI', 'MI', 'acute myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events']

answer: @entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']


abstract: BACKGROUND: @entity4760 are a common problem and result in more than 85,000 lower extremity amputations each year in the United States. Studies have suggested that between 25% and 50% of costs related to inpatient @entity6 care may be directly attributable to the @entity6 foot. Novel treatments for these wounds, while expensive, have been reported to improve healing rates, although no formal cost effectiveness analyses have been performed in order to address the cost effectiveness of a given therapy. OBJECTIVE: To estimate the cost effectiveness of common treatment strategies for @entity4760 . METHODS: Four main options are available for the treatment of @entity4760 : (1) standard care (SC), (2) standard treatment in a specialized wound care center (WCC), (3) treatment with @entity35745 , (4) or treatment with platelet releasate (PR). We utilized effectiveness data from published clinical trials, meta-analyses, and a database that includes data on 26,599 @entity1 with these wounds. Effectiveness was assessed as a percentage of @entity1066 healed at 20 and 32 weeks. RESULTS: Baseline effectiveness (with 95% confidence intervals) for SC, @entity35745 , PR, and WCC care were 30.9% (26.6, 35.1), 43.0% (37.3, 48.7), 36.8% (35.4, 38.2), and 35.6% (34.8, 36.4), respectively. Cost:effectiveness ratios for PR versus SC and @entity35745 versus SC were 414.40 and 36.59, respectively. Therefore the incremental cost of increasing the odds of healing by 1% over standard therapy was  414.40 for PR and  36.59 for @entity35745 . CONCLUSIONS: PR, @entity35745 , and WCC care all provided improved healing rates over standard care, and @entity35745 was less expensive and more effective than PR after 20 weeks of care.

title: Treatment options for XXXX : a cost-effectiveness analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity35745 :: ('MESH:C072194', 'Chemical') :: ['becaplermin']

entities_list: @entity4760 :: ('MESH:D017719', 'Disease') :: ['diabetic foot ulcers', 'Diabetic foot ulcers', 'diabetic neuropathic foot ulcers']

answer: @entity4760 :: (MESH:D017719,Disease) :: ['diabetic neuropathic foot ulcers']


abstract: It was the objective of this study to evaluate MR-guided, percutaneous @entity1068 injection of @entity157 in ten @entity1 scheduled for liver transplantation. Using a 0.2 T open MR scanner (Magnetom Open, Siemens Medical Systems, Erlangen, Germany) and percutaneous instillation of @entity1068 , 12 @entity96 (median @entity5 volume, 6.3; range, 0.6-43.2 ccm) were treated. Coagulation @entity39 , morbidity, and post-transplant histology were assessed. No major complications were observed. A mean of 16.4+/-11.4 ml @entity1068 was injected for each @entity5 . The median volume of the ablation @entity39 was 12.3 (range, 0.3-48.3) ccm. Three @entity5 were retreated and complete radiological @entity39 before liver transplantation was found in eight of 12 @entity5 (67%). One @entity1 developed @entity66 and was excluded from transplantation; thus nine of ten @entity1 underwent liver transplantation within 3.9+/-3.1 months. In the explants, satellite nodules (n = 2), new @entity96 (n = 2) and a complete @entity39 were found in five of 12 treated @entity5 (42%). During follow-up (median 41.3; range, 0.4-86.1 months), three @entity1 died, but no @entity5 -seeding or post-transplantation recurrence occurred. MR-guided @entity1068 injection is feasible, and may delay @entity5 progression. However, the local recurrence rate is high, and the spatial resolution of a low-field MR scanner limits the detection of small @entity5 .

title: MR-guided percutaneous XXXX ablation of @entity157 before liver transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['multifocal disease']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']


abstract: PURPOSE: To analyze the clinical presentation, microbiological evaluation, and management of post- @entity231 surgery @entity281 . METHODS: This is a retrospective chart review of 11 @entity1 with @entity281 after @entity231 surgery, managed between November 2006 and October 2009. The clinical characteristics and treatment outcomes were analyzed. RESULTS: All @entity1 presented within 1 to 10 weeks of primary surgery. The presenting visual acuity ranged from hand motions to 20/50. Ten of 11 @entity1 had sclerocorneal involvement, and 4 @entity1 had associated @entity3225 . The causative organisms were fungus (n = 6), bacteria (n = 4), or both (n = 1). Deroofing of the tunnel and sclerocorneal patch graft was done in 4 @entity1 . Intensive medication was administered to all @entity1 . The final visual acuity ranged from light perception to 20/50 at a mean follow-up of 119 days (median, 66 days; range, 2-357 days). Five @entity1 had >= 20/100 vision. The mean interval between presentation to resolution of infiltrate and formation of peripheral scarring was 20 days (median, 11 days; range, 2-66 days). CONCLUSIONS: @entity281 must be microbiologically evaluated. Intensive medical management, wound revision and repair may lead to a favorable outcome.

title: Clinicomicrobiological characteristics and treatment outcome of XXXX .

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Sclerocorneal tunnel infection', 'sclerocorneal tunnel infection']

entities_list: @entity3225 :: ('MESH:D009877', 'Disease') :: ['endophthalmitis']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

answer: @entity281 :: (MESH:D007239,Disease) :: ['sclerocorneal tunnel infection']


abstract: We did a @entity1030 ( @entity1030 ) @entity1 without chronic use of systemic glucocorticoids (CUG). @entity170 was found in 51% and @entity79 ( @entity79 ) was correlated with severity of disease. Low levels of @entity560 were found in 94%. All @entity1030 @entity1 may benefit from @entity560 supplementation and screening for low @entity79 . INTRODUCTION: @entity1 with chronic @entity3885 have low @entity79 , caused by chronic use of systemic glucocorticoids and hypovitaminosis D. However, @entity1 without CUG may also have low @entity79 . METHODS: We performed a cross-sectional analysis in 49 @entity1 (21 @entity1 , 28 postmenopausal @entity1 ), with @entity1030 without CUG, from Brazil (25 degrees 25' S). Several markers of bone metabolism were measured, plus @entity79 . @entity170 risk factors and history of @entity174 were investigated. Respiratory function was assessed by venous gasometry, spirometry, and oximetry. @entity79 results were compared to those of 40 healthy non-smokers controls. RESULTS: @entity1030 @entity1 had lower @entity79 at all sites (p < 0.01). @entity170 was observed in 51%. @entity79 independently correlated with @entity5 (lumbar spine, R = 0.38, p = 0.01; total femur, R = 0.36, p = 0.01; femoral neck, R = 0.40, p < 0.01). Ninety-four percent had low levels of @entity560 (<30 ng/mL) and 67% had @entity3528 . @entity560 was correlated with @entity26 saturation (R = 0.36, p = 0.01), with lower levels in those with saturation <88% (p = 0.01). CONCLUSION: @entity1 with @entity1030 without CUG have increased risk for @entity170 . Such @entity1 have hypovitaminosis D, which is correlated with the severity of disease. Screening for low @entity79 and @entity560 supplementation may be warranted to all @entity1030 @entity1 .

title: XXXX is associated with @entity170 and low levels of @entity560 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage of disease']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['Osteoporosis', 'osteoporosis']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['pulmonary obstructive disease']

entities_list: @entity3528 :: ('MESH:D006962', 'Disease') :: ['secondary hyperparathyroidism']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['cross-sectional analysis of chronic pulmonary obstructive disease', 'COPD']

entities_list: @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D', 'Vitamin D']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['Chronic obstructive pulmonary disease']


abstract: The purpose of this study was to demonstrate that living bone allotransplants can incorporate, remodel, and maintain mechanical properties without long-term immunosuppression in a fashion comparable to living autotransplants. For this, viability is maintained by repair of nutrient vessels and @entity2295 from implanted host-derived vasculature. Microsurgically revascularized femoral diaphysis allotransplants were transferred from young male New-Zealand-White (NZW) into 4 groups of male Dutch-Belted (DB) @entity95 . Short-term immunosuppression by @entity1140 (IS, groups 4 and 5) and host-derived @entity2295 ( @entity2295 ) from @entity4438 was used to maintain viability (groups 3 and 5) as independent variables. Group 2 received neither IS nor @entity2295 . Vascularized pedicled autotransplants were orthotopically transplanted in group 1. After 16 weeks, transplants were evaluated using radiologic, histologic, biomechanical, and histomorphometric parameters. Vascularized bone allotransplants treated with both short-term IS and host-derived @entity2295 (group 5) healed in a fashion similar to pedicled autotransplants (group 1). Their radiographic scores were higher than other groups. Groups with @entity4438 (3 and 5) showed significantly greater neoangiogenesis than ligated controls (2 and 4). @entity1140 administration did not affect neoangiogenesis. Elastic modulus and ultimate stress were significantly greater in autogenous bone than in allotransplanted femora. Biomechanical properties were not significantly different among allotransplants. Bone turnover was decreased with IS, but increased with @entity2295 by the @entity4438 . Living allogeneic femoral allotransplants treated with short-term IS and host-derived neoangiogenesis can lead to stable transplant incorporation in this @entity95 model. The combination of both factors optimizes bone healing. Transplant mineralization is improved with neoangiogenesis but diminished with IS.

title: Host-derived neoangiogenesis with short-term immunosuppression allows incorporation and remodeling of vascularized diaphyseal allogeneic XXXX femur transplants.

entities_list: @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularization', 'NV']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity4438 :: ('MESH:C563219', 'Disease') :: ['patent fascial flaps', 'implanted fascial flaps']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['Tacrolimus', 'tacrolimus']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: @entity778 ( @entity778 ) @entity1014 kinase (tk) gene incorporated into adenovirus was delivered intraperitoneally (ip) followed by an antiherpetic prodrug and topotecan in @entity1 with recurrent @entity43 . Tissue response was evaluated. Ten @entity1 underwent secondary debulking with subsequent delivery of ADV- @entity778 -tk therapy. Two @entity1 each were treated at dose level 1 (2 x 10(10) vector particles = @entity3548 ), 2 (2 x 10(11) @entity3548 ), and 3 (2 x 10(12) @entity3548 ); four @entity1 were treated at dose level 4 (2 x 10(13) @entity3548 ). Five @entity1 underwent second-look surgery about one month after @entity74 ( @entity74 ). Treatment response, presence of vector DNA, protein expression of @entity134 hormone receptors, @entity876 , @entity1722 and Ki67 protein were analyzed. At second-look, two out of five @entity1 were @entity5 -free and none of their peritoneal biopsies showed vector DNA. After @entity5 mass was smaller, desmoplastic reaction had increased, and @entity5 were less differentiated with an increase of Ki67 expression. There was no change in expression of hormone receptors, @entity876 , or @entity1722 . ADV- @entity778 -tk @entity74 appears to eliminate cells with higher differentiation first and might induce @entity82 . Dedifferentiation might render residual cells more sensitive to chemotherapy secondary to their subsequent higher mitotic activity.

title: Histologic and immunohistochemical analysis of tissue response to adenovirus-mediated herpes simplex XXXX kinase @entity74 of @entity43 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['Herpes simplex virus', 'HSV']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['epithelial ovarian cancer']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'GT, the vital tumor', 'tumors']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['gene therapy', 'GT']

entities_list: @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine']

answer: @entity1014 :: (MESH:D013936,Chemical) :: ['thymidine']


abstract: We have previously demonstrated that aging is associated with @entity55 in a @entity19 model of @entity130 . To further investigate these observations, we examined @entity358 , markers of neutrophil chemotaxis and adhesion, and lung endothelia responses in young and aged @entity19 following @entity130 . Analysis of lung tissue and bronchoalveolar lavage fluid 24 hours after injury revealed that more neutrophils accumulated in the lungs of aged @entity19 (p<0.05), but did not migrate into the alveoli. We then sought to determine if accumulation of neutrophils in the lungs of aged @entity19 was due to differences in the peripheral neutrophil pool or local changes within the lung. Following @entity130 , aged @entity19 developed a pronounced peripheral blood neutrophilia (p<0.05) in comparison to their younger counterparts. In aged animals, there was a reduced frequency and mean fluorescent intensity of neutrophil @entity18510 expression (p<0.05). Interestingly, in uninjured aged @entity19 , peripheral blood neutrophils demonstrated elevated chemokinesis, or hyperchemokinesis, (p<0.05), but showed a minimal chemotatic response to KC. To determine if age impacts neutrophil adhesion molecules, we assessed @entity6232 and @entity3804 expression on peripheral blood neutrophils. No age-dependent difference in the frequency or mean fluorescent intensity of @entity6232 or @entity3804 was observed post-burn @entity130 . Examination of pulmonary vasculature adhesion molecules which interact with neutrophil selectins and integrins revealed that @entity8024 ( @entity8024 ) was elevated in aged @entity19 at 24 hours after burn as compared to young @entity19 (p<0.05). Overall, our data suggests that age-associated pulmonary congestion observed following @entity130 may be due to differences in lung endothelial adhesion responses that are compounded by elevated numbers of hyperchemokinetic circulating neutrophils in aged @entity19 .

title: Dysregulation of neutrophil @entity18510 and pulmonary endothelial @entity8024 promotes age-related XXXX .

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['prolonged pulmonary inflammation']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung congestion']

entities_list: @entity8024 :: ('15894(Tax:10090)', 'Gene') :: ['ICAM-1', 'intracellular adhesion molecule-1']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['trauma', 'burn injury', 'thermal injury']

answer: @entity55 :: (MESH:D011014,Disease) :: ['pulmonary inflammation']


abstract: We produced monoclonal antibodies (mAbs) against @entity6763 ), Los Angeles strain, and then evaluated them as potential candidates for preparing diagnostic reagents. Of the 318 cell lines expressing antibodies to the virus, 60% (192) secreted IgG and 40% (126) secreted IgM. Twenty-six mAbs were selected based on enzyme-linked immunosorbent assay (ELISA) and virus neutralization (VN) titers and characterized by immunoprecipitation, immunofluorescence and immunoblots. The selected mAbs were assigned to one of four groups based on their immunoprecipitation patterns. Group A (4 mAbs) precipitated a complex of three glycoproteins with molecular weight (MW) 130 kDa, 72 kDa and 55 kDa, which presumably represented gI of BHV-1. Monoclonal antibodies of this group were highly reactive in ELISA but had low VN titers. Group B (4 mAbs) precipitated a glycoprotein with MW of 71 kDa ( @entity24396 ). This group of mAbs had high VN titers. Group C (16 mAbs) precipitated a 97 kDa glycoprotein (gIII). Monoclonal antibodies of this group had high ELISA but low VN titers. Group D (2 mAbs) precipitated a double band of non-glycosylated proteins with MW of 37/32 kDa; these proteins could not be assigned to any of the antigens of @entity4374 previously described. ELISA and VN titers of this group of mAbs were low. To test the antigenic variability of the antigenic determinants which were recognized by these 4 groups of mAbs, we adapted Madin Darby @entity291 kidney cell-propagated @entity4374 Los Angeles strain to Crandell's feline kidney cell line. After the tenth passage in feline kidney cells, the epitopes on the 37/32 kDa peptide recognized by the mAbs group D were no longer detectable. Additional changes were noted in the electrophoretic mobility of the 130 kDa and 71 kDa glycoproteins (gI) identified by mAb of group A shifted downward. The 71 kDa glycoprotein ( @entity24396 ) reactive with mAb group B and the 97 kDa (gIII) reactive with mAb group C remained stable. Since clone No. 191 of group B mAb was potent in ELISA, VN, immunoblots and immunofluorescence, and recognized an epitope which did not change under selective pressure, we feel that the mAb produced by this clone are a good candidate for the production of diagnostic reagents.

title: Characterization of monoclonal antibodies to XXXX herpesvirus type I, Los Angeles strain.

entities_list: @entity6763 :: ('10320', 'Species') :: ['bovine herpesvirus type 1 (BHV-1']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: @entity54257 , NR5A1a) is a member of the NR5A nuclear receptor subfamily and has been implicated as a key transcriptional regulator of all ovarian steroidogenic genes in vitro. To establish links between the expression of @entity54257 and that of the steroidogenic genes in vivo, the objectives of this study were to clone @entity1641 @entity54257 and examine the regulation of its messenger RNA (mRNA) in follicular cells during @entity1 CG (hCG)-induced ovulation. The @entity1641 @entity54257 primary transcript was cloned by a combination of RT-PCR techniques. Results showed that the transcript was composed of a 5'-untranslated region (UTR) of 161 bp, an open reading frame (ORF) of 1386 bp that encodes a highly-conserved 461-amino acid protein, and a 3'-UTR of 518 bp. The cloning of @entity54257 also led to the unexpected and serendipitous isolation of the highly-related orphan nuclear receptor @entity54258 , which was shown to include a 5'-UTR of 243 bp, an ORF of 1488 bp, and a 3'-UTR of 1358 bp. The @entity54258 ORF encodes a 495-amino acid protein that is 60% identical to @entity54257 , including 99%-similar DNA-binding domains. Northern blot analysis revealed that @entity54257 and @entity54258 were expressed in all major steroidogenic tissues, with the exception that @entity54258 was not present in the adrenal. Interestingly, @entity54258 was found to be, by far, the major NR5A subfamily member expressed in the preovulatory follicle and the corpus luteum. Using a semiquantitative RT-PCR/Southern blotting approach, the regulation of @entity54257 and @entity54258 mRNAs in vivo was studied in @entity1641 follicular cells obtained from preovulatory follicles isolated between 0 and 39 h post hCG. Results showed that the theca interna was the predominant site of @entity54257 mRNA expression in the follicle, and that hCG caused a significant decrease in @entity54257 levels between 12-39 h in theca interna and between 24-39 h post hCG in granulosa cells (P < 0.05). In contrast, the granulosa cell layer was the predominant, if not the sole, site of @entity54258 mRNA expression in the follicle. Importantly, @entity54258 was much more highly expressed in granulosa cells than @entity54257 . The administration of hCG caused a significant decrease in @entity54258 transcripts in granulosa cells at 30, 36, and 39 h post hCG (P < 0.05). Thus, this study is the first to report the concomitant regulation of @entity54257 in theca interna and granulosa cells throughout the ovulation/luteinization process, and to demonstrate the novel expression and hormonal regulation of @entity54258 in ovarian cells. Based on the marked expression of @entity54258 in @entity1641 granulosa and luteal cells and on mounting evidence of a functional redundancy between @entity54257 and @entity54258 in other species, it is proposed that @entity54258 may play a key role in the regulation of gonadal steroidogenic gene expression.

title: Expression and regulation of transcripts encoding two members of the NR5A nuclear receptor subfamily of orphan nuclear receptors, steroidogenic factor-1 and XXXX , in @entity1641 ovarian cells during the ovulatory process.

answer: @entity54258 :: (100009700(Tax:9796),Gene) :: ['NR5A2']


abstract: We evaluated the results of surgical treatment of @entity741 with @entity1455 in ten @entity1 . Seven of 10 @entity1 survived after surgery. Other three @entity1 died of @entity881 (two @entity1 ) or severe left @entity67 (one @entity1 ). Two @entity1 with previous @entity1188 survived. Lesions in the group of survivors after surgery were left main trunk (LMT) disease in one @entity1 , three @entity66 (3VD) in two, 2VD in two and 1VD in two @entity1 . All nonsurvivors had LMT disease. Two @entity1 died in whom preoperative electrocardiography (ECG) had shown Q wave. No significant difference in periods from onset to start of cardiopulmonary bypass (CPB) and from onset to recanalization was found between survivors and nonsurvivors. CPB time and aorta cross-clamp time in survivors were similar to those in nonsurvivors. At 24-hour after operation, pulmonary capillary wedge pressure in survivors showed significantly low value compared to that in nonsurvivors (12.8 +/- 3.9, 19.3 +/- 1.5 mmHg, respectively, p less than 0.05). Four @entity1 out of seven survivors were in 1 of Forrester's classification, two in 2 and one in 3. Of three nonsurvivors, one were in 3 and two in 4. We conclude that mortality related to three risk factors: (1) LMT disease, (2) Q wave in preoperative ECG, and (3) hemodynamic state at 24-hour after operation.

title: [Surgical treatment of @entity741 with XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['vessel disease']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular power failure']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

answer: @entity1455 :: (MESH:D012770,Disease) :: ['cardiogenic shock']


abstract: OBJECTIVE: Lispro is a newly FDA-approved analog of @entity1 @entity2690 that will be widely used in @entity1 with @entity1723 . This @entity2690 , however, may have an increased potential for @entity4053 because of its very rapid subcutaneous absorption, especially in a setting of decreased @entity1735 intake. Using a short-term prospective randomized parallel group-study design, we studied the incidence of @entity4053 when lispro was given before breakfast compared with regular @entity1 @entity2690 . Since @entity1735 intake is a determinant of postprandial glycemia, we administered three isocaloric meals characterized by low, average, and high @entity1735 content. RESEARCH DESIGN AND METHODS: Two groups of six @entity1723 subjects were randomized to receive 0.15 U/kg of lispro or regular @entity1 @entity2690 subcutaneously before the ingestion of three 500-kcal breakfast meals of differing @entity1735 content on separate days. Lispro was administered at mealtime, and regular @entity2690 was administered 30 min before mealtime. RESULTS: Postprandial plasma @entity413 concentrations were decreased in the lispro group compared with the regular- @entity2690 group for all three meal types (P < 0.05), and @entity4053 developed more frequently and rapidly in the lispro group, compared with the regular- @entity2690 group by survival analysis. Additionally, peak @entity2690 concentrations were higher (P < 0.001) and peaked more rapidly (P < 0.05) in the lispro group, compared with the regular- @entity2690 group. CONCLUSIONS: We conclude that lispro has a tendency for early postprandial @entity4053 compared with regular @entity2690 in the setting of reduced @entity1735 intake. This fact should be told to @entity1 who decide to switch from regular @entity2690 to lispro. Health care professionals should instruct their @entity1723 @entity1 to monitor @entity413 levels frequently after switching to lispro since adjustments in their @entity1735 intake and/or their lispro dosage may be necessary to avoid @entity4053 .

title: Meal composition is a determinant of lispro-induced XXXX in @entity1723 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']


abstract: INTRODUCTION: The renal tubules play important roles in substance re-absorption from primary urine of the kidney, drug metabolism and gluconeogenesis in fasting and are vulnerable targets of nephrotoxic chemicals. Therefore, an appropriate functional model of renal tubules would enable the study of their functionality and chemical-induced @entity137 . We have developed a method to maintain primary renal tubules and sustain their biochemical functionality in culture for an extended period of time. METHODS: Primary @entity35 renal tubules were isolated from male @entity35 kidneys by collagenase perfusion and the tubules maintained in culture as a suspension by a gyratory culture method. RESULTS: The tubule fragments gradually formed renal tubule aggregates within 6days and were maintained in culture for up to 12days without apparent morphological changes. Biochemical functions including @entity413 release, @entity3649 uptake and @entity2388 uptake were retained for the observed period of 12days after isolation. The aggregates showed significant @entity7772 activity recovery from day 6 after isolation and this was maintained thereafter during the 12-day period of in-vitro culture. A new @entity137 test termed the cell spreading inhibition test (CSIT) of renal tubule aggregates was developed to study the effect of toxicants on cell spreading/growth and determine the minimum concentration of each toxicant that caused cell spreading inhibition (CSI-C). The CSI-Cs of selected nephrotoxic drugs were determined as @entity2644 (60 M), @entity900 (200 M), diclofenac (800 M), @entity1092 (10mM), and @entity801 (30mM). DISCUSSION: The gyratory method of primary renal tubule aggregate culture can retain tubular cell functions such as @entity413 release, @entity3649 uptake and allow @entity7772 activity to recover, which are essential for an in-vitro model. Therefore, renal tubule aggregates can be used as a model for studies of biochemical functions of renal tubules and relative @entity8 of nephrotoxic agents.

title: In-vitro maintenance and functionality of primary renal tubules and their application in the study of relative XXXX of nephrotoxic drugs.

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamycin']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal toxicity']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine']

entities_list: @entity3649 :: ('MESH:D005690', 'Chemical') :: ['galactose']

entities_list: @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal toxicity']


abstract: BACKGROUND: The @entity425 commonly associated with @entity626 is widely believed to result from disuse atrophy secondary to @entity158 in the involved joint. However, @entity425 may be an etiologic factor in the development of @entity571 . OBJECTIVE: To explore the relation between @entity425 and @entity626 . DESIGN: Cross-sectional prevalence study. SETTING: Population-based, with recruitment by random-digit dialing. @entity1 : 462 volunteers 65 years of age or older. MEASUREMENTS: Radiographs of the knee were graded for the presence of @entity571 . Knee @entity158 and function were assessed with the Western Ontario and McMaster Universities Arthritis Index, the strength of leg flexors and extensors was assessed with isokinetic dynamometry, and lower-extremity lean tissue mass was assessed with dual-energy x-ray absorptiometry. RESULTS: Among @entity1 with @entity571 , @entity425 , but not hamstring weakness, was common. The ratio of extensor strength to body weight was approximately 20% lower in those with than in those without radiographic @entity571 . Notably, among @entity1 with @entity571 , @entity425 was present in the absence of knee @entity158 and was seen in @entity1 with normal lower-extremity lean mass (extensor strength, 30.1 lb-ft for those with @entity571 and 34.8 lb-ft for those without @entity571 ; P < 0.001). After adjustment for body weight, age, and sex, lesser quadriceps strength remained predictive of both radiographic and symptomatic @entity626 (odds ratio for prevalence of @entity571 per 10 lb-ft loss of strength, 0.8 [95% CI, 0.71 to 0.90] for radiographic @entity571 and 0.71 [CI, 0.51 to 0.87] for symptomatic @entity571 ). CONCLUSION: @entity425 may be present in @entity1 who have @entity571 but do not have knee @entity158 or @entity2057 ; this suggests that the weakness may be due to @entity121 . The data are consistent with the possibility that @entity425 is a primary risk factor for knee @entity158 , disability, and progression of @entity16 in @entity1 with @entity626 .

title: @entity425 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'PARTICIPANTS', 'persons']

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['osteoarthritis of the knee']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['tibiofemoral osteoarthritis', 'osteoarthritis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['joint damage']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['lower-extremity weakness', 'Quadriceps weakness', 'quadriceps weakness', 'extensor weakness']

entities_list: @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscle atrophy']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle dysfunction']

answer: @entity626 :: (MESH:D020370,Disease) :: ['osteoarthritis of the knee']


abstract: Since March 1986, coronary artery bypass grafting (CABG) by utilizing the right @entity432 ( @entity432 ) has been performed in 60 @entity1 during 3 year period. There were 52 males and 8 females, and age ranged from 34 to 73 year old with the mean of 56.2 year old. @entity66 and the left main disease involved 90% of the @entity1 . There were two @entity1 under hemodialysis for @entity177 , one @entity1 with @entity3039 , one @entity1 with @entity439 of the abdominal aorta, and two @entity1 with @entity4288 obliterance, preoperatively. Five @entity1 were second CABG. @entity432 was used as an in-situ graft in 57 @entity1 and as a free graft in 3 @entity1 and was anastomosed to 3 left anterior descending, 3 diagonal (all "free" graft), 5 circumflex, and 49 right coronary arteries. To bypass the other coronary arteries, the internal mammary artery graft (unilateral 38, bilateral 20, sequential 5) with or without saphenous vein graft was used. The mean number of distal anastomoses was 3.3 (1-5) and the mean number of arterial graft anastomoses was 2.4 (1-4) per @entity1 with the mean aortic cross clamp time of 62.4 minutes (23-137 minutes) and the mean cardiopulmonary bypass time of 120.8 minutes (69-210 minutes). Splenectomy, Y graft replacement of the abdominal aorta, and ascending aorta-bifemoral bypass were concomitantly carried out in each one @entity1 . Two @entity1 (3.3%) died of renal and @entity712 within 30 postoperative days. One @entity1 (1.7%) died of @entity64 lately. New Q wave was noted in 2 @entity1 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Coronary artery bypass grafting using XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Triple vessel disease']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['gastroepiploic artery', 'GEA']

entities_list: @entity3039 :: ('MESH:D016553', 'Disease') :: ['idiopathic thrombocytopenic purpura']

entities_list: @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis']

answer: @entity432 :: (MESH:D001157,Disease) :: ['gastroepiploic artery']


abstract: PURPOSE: Recently, we found that @entity53 induces cytokine and MMP gene expression in SV40 immortalized @entity1 corneal epithelial cells (SV40 HCEs). The purpose of this study was to determine if @entity53 stimulates MMP secretion by cultures of SV40 HCEs and primary @entity1 corneal epithelial cells. Further, we determined if @entity172 influenced cytokine and MMP gene expression in the primary cultures. METHODS: Gelatin zymography was used to identify @entity1476 and @entity1495 gelatinase activity in the culture medium from SV40 HCEs and primary @entity1 corneal epithelial cell cultures exposed to vehicle or @entity53 for 6 or 24 hour. In addition, @entity53 effects on cytokine and MMP gene expression in primary cultures were evaluated by real-time PCR methods. RESULTS: @entity53 had no significant effects on MMP activity in the culture media of either SV40 HCEs or primary corneal epithelial cell cultures. SV40 HCEs secreted predominantly @entity1476 , whereas the primary cultures secreted predominantly @entity1495 . In primary cultures, @entity53 caused a significant decrease of @entity650 and @entity687 gene expression, but had no effect on the levels of @entity1356 , @entity1476 , and @entity1495 gene expression. CONCLUSIONS: Our findings suggest that @entity53 effects on gelatinase gene expression in SV40 HCEs are not translated into changes in secreted MMP activity. @entity172 influences on gene expression of cytokine and MMPs in primary cultures are different from those in SV40 HCEs.

title: Comparative effects of @entity172 on matrix metalloproteinases and cytokines in immortalized and primary XXXX corneal epithelial cell cultures.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: A total of 316 @entity1 were included in a play-the-winner (PTW) designed study comparing the safety of enoxaparin started preoperatively versus postoperatively as prophylaxis against @entity1211 for digestive surgery. In a PTW-designed study the treatment of any next @entity1 depends on the outcome of the previous @entity1 . If successful, the next @entity1 receives the same treatment, if not, the comparative regimen is given. Excessive @entity548 according to specified criteria, severe adverse reactions, clinically detected @entity1150 ( @entity1150 ), or @entity1151 ( @entity1151 ) were criteria for classification as "loser." The PTW design allocates most @entity1 to the superior treatment. The main variable in PTW studies is the number of consecutive @entity1 receiving the same treatment. In this study 163 @entity1 were allocated to postoperatively started and 153 to preoperatively started prophylaxis with enoxaparin. The frequency of "winners" was found to be 82.8% and 78.4% in the post- and preoperatively treated groups, respectively. No significant differences were found between the groups with regard to frequency of "winners" or the number of consecutive @entity1 before change of treatment. The percentile of survival distribution did not detect superiority of any group. Prophylaxis against @entity1211 for digestive surgery using enoxaparin can safely be started preoperatively.

title: Evaluation of enoxaparin given before and after operation to prevent XXXX during digestive surgery: play-the-winner designed study.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['PE', 'pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis', 'DVT']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['postoperative venous thromboembolism', 'venous thromboembolism']

answer: @entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolism']


abstract: In areas where the agent of Lyme disease is intensely enzootic, the @entity19 reservoirs may be universally infected. Because a large proportion of the vector tick population appears to feed upon these hosts, the prevalence of @entity281 in the vectors should approach 100%. However, @entity281 in host-seeking nymphal ticks in nature rarely exceeds 40%. To help reconcile this apparent paradox, we examined whether estimates of prevalence might differ if we did not assume that infected ticks are randomly or uniformly distributed within a site. Nymphal @entity3966 were collected by dragging a series of 10-meter replicates within an intensely enzootic site. Estimates of the prevalence of @entity24553 , based upon the monthly means of individual 10-meter collections, were then compared with estimates derived by pooling all samples. Host-seeking ticks tended to cluster. The @entity2069 was present in 15.6% of 469 pooled ticks. When the prevalence estimate was based solely on ticks in clusters that contained one or more infected ticks, however, at least 50% of the ticks were infected. We conclude that nymphal @entity3966 infected by @entity2069 tend to aggregate spatially in nature, and that prevalence estimates based upon a mean value for pools may be misleading.

title: Clustering of host-seeking nymphal @entity3966 ( @entity3966 ) infected by @entity2069 ( XXXX ).

entities_list: @entity2069 :: ('139', 'Species') :: ['Lyme disease spirochetes', 'Lyme disease spirochete']

entities_list: @entity3966 :: ('6945', 'Species') :: ['deer ticks', 'Ixodes dammini']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity24553 :: ('MESH:D013145', 'Disease') :: ['spirochetal infection']

answer: @entity2069 :: (139,Species) :: ['Borrelia burgdorferi']