abstract: INTRODUCTION: @entity5011 is one of the most important causes of @entity295 of vertical transmission (1-2% of the carriers). The @entity281 may involve @entity204 or severe complications. The culture of vaginal and rectal @entity5011 is a screening test and it is performed to all pregnant @entity1 between 35-37 weeks of gestation. If it is positive, intrapartum @entity114 is prescribed. If it is negative or unknown, the antibiotic per protocol is given according to risk factors: rupture of membranes more than 18 hours, intrapartum temperature, or prematurity. The aim of this study is to quantify @entity1 who receive intrapartum antibiotic in relation to the positive culture and achievement with the SEGO's recommendation. MATERIAL AND METHODS: It describes a sample of 261 @entity1 of the Txagorritxu Hospital who have given birth during the work shift of researchers, excluding cesarean sections. VARIABLES: results of culture, antibiotic administration. Data were collected by reviewing and analyzed medical records using SPSS 17.0. RESULTS: From 261 @entity1 , 69 (26.4%) received antibiotic administration. From 69, 46 (66.67%) had a positive culture. 26 (37.68%) received antibiotics according to risk factors, although their cultures were negative or unknown. DISCUSSION: The results suggest there is a correct application of the SEGO's recommendation. Carrier @entity1 with no risk factors would not have received antibiotic therapy without screening.

title: [Descriptive study of intrapartum antibiotic prophylaxis of XXXX by group B Streptococcus in Txagorritxu].

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['neonatal sepsis']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ["newborn's death"]

answer: @entity281 :: (MESH:D007239,Disease) :: ['neonatal infection']


abstract: NudE-Like ( @entity40346 /NUDEL), through its interaction with LIS1 and @entity40347 , has been implicated in the etiology of @entity16 such as @entity12199 and @entity161 , respectively. Subsequently, a large portion of the research done on the function of @entity40346 has been specifically targeted to its role in brain development while ignoring its function in other developing and adult tissues. To begin a more global exploration of @entity40346 's function, this study characterizes the developmental expression pattern of the @entity40346 orthologs in the @entity3392 embryo. Our bioinformatic analyses identified two @entity40346 orthologs in the @entity3392 , @entity40348 and @entity40349 . @entity40348 is expressed predominantly in the anterior central nervous system (CNS), trigeminal ganglia, and eyes while @entity40349 is expressed in the developing somites and, later, in the CNS. In addition to the spatial differences in their expression patterns, these genes are also individually regulated in their temporal expression. Both are expressed maternally but at later time-points there are subtle differences. @entity40348 expression is lost between 6 and 12 hpf but then increases to a higher, near steady state, level from 72 to 120 hpf. @entity40349 expression decreases from 3 to 36 hpf and subsequently increases from 36 to 120 hpf. The non-overlapping expression patterns of these two orthologs may indicate that they have split the functional role of the one @entity40346 gene present in @entity1 species. The temporal and spatial regulation of these two orthologs will aid in the characterization of the multiple functions of this gene in both the developing and mature organism.

title: Expression profiles of @entity40348 and XXXX , two orthologs of the NudE-Like gene, in the @entity3392 .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders']

entities_list: @entity12199 :: ('MESH:D054082', 'Disease') :: ['lissencephaly']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity40349 :: (333957(Tax:7955),Gene) :: ['ndel1b']


abstract: @entity195 ( @entity195 ) is a @entity74 for which various in vivo models exist. The TgCRND8 @entity19 , transgenic for the @entity1 @entity477 , is an aggressive early onset model of @entity75 . Preliminary studies revealed that when the transgene is expressed on an A/J genetic background, these @entity19 not only survive longer but also deposit less parenchymal amyloid-beta ( @entity15370 ) peptides as compared to those on a C57BL/6 background. We performed a genome-wide study of an F2 intercross between TgCRND8 on an A/J background and C57BL/6 @entity19 , to identify genetic modulators of amyloid accumulation and deposition. We identified four highly significant QTLs that together account for 55% of the phenotypic variance in the number of plaques (Thioflavin S). QTLs were found on the distal part of chromosome 4 with an LOD score of 8.1 at D4Mit251, on chromosome 11 with an LOD score of 5.5 at D11Mit242, on chromosome 9 with an LOD score of 5.0 at D9Mit336 and on the proximal part of chromosome 8 with an LOD score of 4.5 at D8Mit223. A/J alleles at these loci are protective and all decreased the amount of @entity15370 deposition. Interestingly, the QTL on chromosome 11 is also significantly linked to the levels of brain @entity15370 (42) and @entity15370 (40). Although these QTLs do not control the levels of plasmatic @entity15370 , other regions on chromosomes 1 and 6 show significant linkage. Further characterization of these QTL regions may lead to the identification of genes involved in the pathogenesis of @entity195 .

title: Mapping genetic modulators of amyloid plaque deposition in TgCRND8 XXXX .

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain amyloid deposition']

entities_list: @entity477 :: ('351', 'Gene') :: ['amyloid precursor protein']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['complex disorder']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity19 :: (10090,Species) :: ['transgenic mice']


abstract: OBJECTIVE: The aim of the present study was to investigate the most effective probiotic combinations to prevent @entity204 and @entity3166 ( @entity3166 ) in a premature @entity35 model. METHODS: One hundred fifty-eight premature Sprague-Dawley premature @entity35 were enrolled. Probiotic strains @entity1335 , @entity13854 , @entity9206 , @entity1336 , and @entity14914 were fed as a single strain or mixture with 2 or 3 strains for a total of 9 study groups; control groups received no exogenous probiotic supplement. Fecal samples were collected for 72 hours to detect probiotic strains and pathologic strains by real-time polymerase chain reaction. Colony counts of probiotic strains @entity526 and @entity4005 were compared between groups before and after 36 hours of the study period. The incidence of @entity204 and @entity3166 were compared via Fisher exact test between groups. RESULTS: The results demonstrated that @entity1336 alone (P = 0.0026) and @entity1335 with @entity13854 together (P = 0.0017) were more effective in reducing @entity3166 as compared with the control group. All of the study groups except @entity14914 and @entity1335 with @entity14914 definitely prevented @entity204 compared with controls. @entity1335 and @entity13854 together had significantly lower mortality than the control group (P < 0.0001). Colony counts of @entity526 and @entity4005 in stool samples were significantly decreased in the @entity1335 , @entity13854 , and @entity1336 group compared with the other study and control groups after 36 hours. CONCLUSIONS: Administration of a mixture of probiotic strains with @entity1335 and @entity13854 was most effective in preventing @entity204 and @entity3166 in this animal model, and these observations provide an evidence-based strategy for designing further neonatal clinical trials.

title: Efficacy of different probiotic combinations on @entity204 and XXXX in a premature @entity35 model.

entities_list: @entity3166 :: ('MESH:D020345', 'Disease') :: ['NEC', 'necrotizing enterocolitis']

entities_list: @entity9206 :: ('1579', 'Species') :: ['Lactobacillus acidophilus']

entities_list: @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella']

entities_list: @entity1335 :: ('1681', 'Species') :: ['Bifidobacterium bifidum', 'B bifidum']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E coli']

answer: @entity3166 :: (MESH:D020345,Disease) :: ['necrotizing enterocolitis']


abstract: BACKGROUND: Torcular or sinus confluence @entity1653 is rare and surgically formidable. This reported sinus confluence @entity1653 was associated with peritumoral @entity1779 . The surgical strategy and the mechanism of peritumoral @entity548 are discussed. CASE DESCRIPTION: A 42-year-old @entity1 presented with a history of @entity10 , @entity391 , and @entity76 for 2 months. Plain computed tomography (CT) scan and magnetic resonance imaging (MRI) demonstrated a high-density mass in the torcular region involving both lateral sinuses. MR angiography demonstrated complete occlusion of the left lateral sinus and straight sinus and @entity850 of the right lateral sinus. Two years after her first operation she experienced sudden @entity10 and @entity1805 . Plain CT scan and MRI showed a hyperintense @entity5 in the torcular region with an @entity1779 in the right occipital lobe. An angiogram demonstrated occlusion of the caudal part of the superior sagittal sinus, bilateral transverse sinuses, and straight sinus. @entity5 was done along with the left lateral sinus through a suboccipital and a supratentorial occipital craniotomy in the first operation. The @entity1 underwent total resection of the @entity5 at second operation through a bilateral occipital and suboccipital craniotomy along with resection of the dura including the confluence, the caudal part of the superior sagittal sinus, the right lateral sinus, and the straight sinus. The postoperative course was uneventful and postoperative MRI showed total @entity5 . CONCLUSION: Sinus confluence @entity1653 may present with peritumoral @entity548 . Radical removal may be possible when the sinus confluence is completely occluded and there is good collateral drainage.

title: Spontaneous peritumoral @entity548 associated with sinus confluence XXXX : case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Gross total removal of the tumor', 'removal of the tumor']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma']

entities_list: @entity1805 :: ('MESH:D006423', 'Disease') :: ['left upper quadrant hemianopsia']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['cerebellar dysfunction']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage', 'intracerebral hematoma']

answer: @entity1653 :: (MESH:D008579,Disease) :: ['meningioma']


abstract: From 1981 to 1987, 81 @entity1 with localized, unresectable @entity788 were treated at Thomas Jefferson University Hospital with a combination of intraoperative @entity1496 -125 implantation, external beam radiation, and peri-operative systemic chemotherapy. Fifty @entity1 had @entity34 and 31 @entity1 had @entity5 . Radioactive @entity1496 -125 seeds were implanted intraoperatively into the @entity5 to deliver a minimum peripheral dose of 12,000 cGy over one year. This was followed by external beam radiation (50-55 Gy) and systemic chemotherapy ( @entity1487 , @entity1138 +/- @entity11770 ). Incidence of peri-operative mortality was 5% (4/81). Early morbidity was observed in 34% of @entity1 and late complications in 32%. A median survival of 12 months and 2- and 5-year survival rates of 21% and 7% were observed. The determinate 2- and 5-year survival rates were 28% and 13%, respectively. The overall 2- and 5-year survival rates with @entity34 were 27% and 8% and for @entity5 , 13% and 3%, respectively (p less than 0.05). The determinate 2- and 5-year survival rates were 34% and 19% for Stage II and 19% and 5% for @entity5 , respectively (p = 0.08). Local control of disease was achieved in 71% of @entity1 . This combined modality approach appears to have achieved satisfactory local control of primary @entity5 and long term survival of selected @entity1 .

title: Long-term results of combined modality treatment with I-125 implantation for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['carcinoma of the pancreas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Stage III disease', 'cancer']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['Mitomycin-C']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['Stage II disease']

answer: @entity788 :: (MESH:D010190,Disease) :: ['carcinoma of the pancreas']


abstract: The transcriptome of seedlings was analyzed from experiments performed on the International Space Station to study the interacting effects of light and gravity on plant tropisms (project named TROPI-2; Kiss et al. 2012). Seeds of @entity958 were germinated in space, and seedlings were then grown in the European Modular Cultivation System for 4  days at ~1g followed by exposure to a range of gravitational accelerations (from microgravity to 1g) and two light treatments (blue light with or without a 1  h pretreatment with red). At the end of the experiments, the cassettes containing the seedlings were frozen in the minus eighty laboratory freezer and returned to Earth on space shuttle mission STS-131. The RNA was extracted from whole seedlings and used for the transcriptome analyses. A comparison of 1g spaceflight samples with 1g ground controls identified 230 genes that were differentially regulated at least twofold, emphasizing the need for "in situ" tissue fixation on a 1g centrifuge as an important control for spaceflight experiments. A further comparison of all spaceflight samples with ground controls identified approximately 280 genes that were differentially regulated at least twofold. Of these genes, several were involved in regulating cell polarity (i.e., auxin, @entity460 , lipid metabolism), cell-wall development, @entity26 status, and cell defense or stress. However, when the transcriptome of the all g-treated spaceflight samples was compared with microgravity samples, only ~130 genes were identified as being differently regulated (P   <=  0.01). Of this subset, only 27 genes were at least twofold differently regulated between microgravity and 1g space samples and included putative/pseudo/undefined genes (14), transposable elements (5), an expansin ( @entity41828 ; At1g21240), a cell-wall kinase ( @entity41829 ; At1g21240), a laccase-like @entity3096 oxidase (TT10; At5g48100), among others.

title: Transcriptome analyses of XXXX seedlings grown in space: implications for gravity-responsive genes.

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis thaliana']


abstract: PURPOSE: To assess the impact of the number of lymph nodes removed and of the template of dissection during radical cystectomy for @entity150 on @entity1 ' survival rates. MATERIALS AND METHODS: We evaluated 282 consecutive @entity1 who underwent radical cystectomy for muscle-invasive or high-grade superficial @entity150 between 1995 and 2011. Exclusion criteria were incomplete follow-up data and neo-adjuvant or adjuvant treatments. @entity1 were divided into groups according to the most informative cut-point of number of lymph nodes retrieved and of the template of dissection. The @entity5 -specific survival rates were estimated by the Kaplan-Meier method. The univariate and multivariable forward-stepwise Cox proportional hazards regression were applied to analyze the survival outcomes. RESULTS: The mean (SD) follow-up was 59.2    44.3 months, and the mean (SD) age of the entire cohort population was 68.3    8.3 years. The @entity5 -specific survival rates were 58.7 and 47.7 % at 5 and 10 years, respectively. Considering both node-positive and node-negative @entity1 , those with at least 14 LNs removed and those submitted to extended or super-extended PLND experienced significantly higher @entity5 -specific survival at both univariate and multivariable analysis. CONCLUSIONS: @entity1 undergoing a more extended pelvic lymph node dissection, both in terms of number of LN removed and in terms of template of dissection, will experience a better @entity5 -specific survival. Our data support a potential role of lymphadenectomy on @entity5 outcome.

title: The number of nodes removed as well as the template of the dissection is independently correlated to XXXX -specific survival after radical cystectomy for @entity150 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Erycibe obtusifolia and Erycibe schmidtii, which belong to the same genus as Erycibe, are widely used in traditional medicine for the treatment of joint @entity158 and @entity309 ( @entity309 ). Porana sinensis has become a widely used substitute for Erycibe obtusifolia and Erycibe schmidtii as they have declined in the wild. In the present work, the content of the main active components, the acute @entity137 , the anti-nociceptive and anti-inflammatory activities of Porana sinensis, Erycibe obtusifolia and Erycibe schmidtii were compared, and the mechanisms of anti-nociceptive and anti-inflammatory activities were discussed. MATERIALS AND METHODS: A quantitative @entity2101 ( @entity2101 ) method was first developed to compare the content of the main active components ( @entity42361 , @entity43330 and @entity13259 ). The anti-inflammatory and anti-nociceptive activities of 40% ethanolic extracts of the three plants were compared using the models of @entity11574 -induced ear @entity4 , @entity406 -induced @entity32 , carrageenan-induced air pouch @entity32 , @entity1543 -induced writhing and @entity406 -induced nociception. The acute @entity137 of the 40% ethanolic extracts of the three plants was studied. RESULTS: The assay suggested a large content of @entity42361 , @entity43330 and @entity13259 in the three plants. The 40% ethanolic extracts of the three plants were almost non-toxic at the dose of 5g/kg and all of them showed significant anti-inflammatory effects in the tests of @entity11574 -induced ear @entity4 and @entity406 -induced @entity32 . In the carrageenan-induced air pouch @entity32 test, the synthesis of @entity1421 was significantly inhibited by all the extracts. They significantly inhibited the number of contortions induced by @entity1543 and the second phase of the @entity406 -induced licking response. @entity1510 was not able to reverse the analgesic effect of these extracts. CONCLUSION: The study identifies the similarity of the three plants in their main active components as well as acute @entity137 , anti-nociceptive and anti-inflammatory activities. It supports the use of Porana sinensis as a suitable substitute, but further studies are needed to confirm this.

title: Comparison of active constituents, acute XXXX , anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity42361 :: ('MESH:D012603', 'Chemical') :: ['scopoletin']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone']

entities_list: @entity2101 :: ('MESH:C538394', 'Disease') :: ['HPLC', 'high performance liquid chromatography']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

entities_list: @entity13259 :: ('MESH:D002726', 'Chemical') :: ['chlorogenic acid']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: BACKGROUND: After therapeutic endoscopy is performed in high-risk @entity1 with peptic @entity1066 , rebleeding occurs in about 25 to 30%. High dose intravenous proton pump inhibitors (PPI) have been recommended for the use in high-risk @entity1 to prevent rebleeding following successful therapeutic endoscopy. OBJECTIVE: Compare the efficacy between @entity10112 high dose bolus injections and continuous intravenous infusion to prevent rebleeding in peptic @entity1066 @entity1 after initial hemostasis is achieved by the therapeutic endoscopy. MATERIAL AND METHOD: A clinical block randomized control trial was conducted at Maharaj Nakorn Chiang Mai Hospital in massive peptic @entity1066 @entity1 . All @entity1 underwent endoscopic diagnosis and treatment within six hours of admission. Hemostasis was achieved by therapeutic endoscopy in 28 @entity1 who received 80 mg @entity10112 as a loading dose before intervention. They were randomized into two groups. The first group was given a high dose of @entity10112 , 40 mg bolus injections twice daily for seven days (n = 13). The second group was given continuous intravenous infusion of @entity10112 , 8 mg per hour for the first three days, followed with a 40 mg bolus injection twice daily similar to the first group from day 4 until day 7 (n = 15). After the seventh day, both groups were given 20 mg of oral @entity10112 once daily for two months. The data was analyzed by Fisher's exact test to compare the frequency of rebleeding within seven days after therapeutic endoscopy. RESULTS: The frequency of recurrent @entity548 between the high dose @entity10112 bolus injection group and the continuous intravenous infusion group was not significantly different, 30.8% and 33.3% respectively (p = 1.0). Three @entity1 in the high dose bolus group and five in the continuous infusion group underwent surgery (p = 0.68). There was no statistically significant difference between the two groups by volume of blood transfusion, length of hospital stay, or mortality. CONCLUSION: In the present study, both PPI drug administration methods showed an equally effective for massive peptic @entity1066 . Further studies with a larger sample size are recommended.

title: Randomized controlled trial of high dose bolus versus continuous intravenous infusion XXXX as an adjunct therapy to therapeutic endoscopy in massive @entity548 peptic @entity1066 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcer bleeding']

entities_list: @entity10112 :: ('MESH:C064276', 'Chemical') :: ['pantoprazole']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity10112 :: (MESH:C064276,Chemical) :: ['pantoprazole']


abstract: @entity2012 increases @entity5 risk. We aimed to determine the prevalence and the predictors of @entity5 in acromegalic @entity1 treated at our department. We retrospectively evaluated 160 acromegalic @entity1 [79 female (mean age 52.0    10.4 years) and 81 male (mean age 49.1    12.4 years)] between 1990 and 2012, with a mean follow up period of 7.1    5.7 years. The @entity1 were screened with colonoscopy, mammography, thyroid and prostate ultrasonography. @entity5 was found in 34 (21.3%) @entity1 . No significant difference was observed in the distribution of @entity5 among sexes (20.3% in F vs. 22.2% in M). @entity259 was the most frequent (n = 17, 10.6%) followed by the @entity0 (n = 4, 2.5%) and @entity14 (n = 3, 1.8%). @entity1358 in two @entity1 , @entity150 in two @entity1 , @entity5 , @entity5 , @entity320 , @entity263 , @entity2 , @entity3975 and @entity361 in brain in one @entity1 were detected. One @entity1 had both @entity1358 . Age of @entity1 at diagnosis of @entity2012 was significantly higher in @entity1 with @entity5 (45.8    9.9 vs. 40.9    11.3 years, p < 0.05). No significant difference was found in duration of the disease, initial GH levels and @entity442 % upper limit of normal values, the prevalence of @entity6 , @entity101 , @entity301 , @entity407 and treatment modalities between the @entity1 with/without @entity5 . In logistic regression analysis, older age at diagnosis was associated with @entity5 risk. The risk of @entity5 in @entity2012 especially the @entity259 risk seems to be more increased than known in the literature. Therefore, @entity2012 @entity1 should be screened routinely for @entity5 , especially for @entity259 due to it being up to four times higher prevalence than breast and @entity14 .

title: Increased XXXX risk in @entity2012 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity3975 :: ('MESH:D018277', 'Disease') :: ['parotid mucoepidermoid carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['periampullary tumor', 'Malignancy', 'cancer', 'rectal carcinoid tumor', 'tumors', 'malignancy']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly', 'Acromegaly']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['Renal cell cancer', 'thyroid and renal cell cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['malignant mesenchymal tumor']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['Thyroid cancer', 'thyroid cancer']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma']

answer: @entity259 :: (MESH:D013964,Disease) :: ['thyroid cancer']


abstract: In @entity43 , no valuable prognostic factors are available so far for predicting biological behaviour and clinical outcome. During the last years, overexpression of @entity1722 -oncogene has been reported to be a prognostic factor in various @entity1 @entity189 . Its prognostic value in @entity43 is still a matter of controversy. The records and histological specimens of 243 @entity1 with primary @entity43 were reviewed. Overexpression of @entity1722 -oncogene encoded transmembrane protein @entity19601 was determined immunohistochemically using polyclonal and monoclonal antibodies. Of 243 investigated @entity5 , 45 (19%) were positive. We examined the relationship between @entity19601 and clinical stage, histological type, grading and prognosis. @entity19601 overexpression differs within the histological subtypes of @entity5 . No correlation was found between @entity19601 overexpression and stage or histological grade. The follow-up data demonstrate that @entity1 with positive staining for @entity19601 have a significantly worse prognosis (p = 0.001) than those with negative staining. These results suggest that overexpression of @entity1722 oncogene is associated with higher biological @entity146 and unfavourable course of disease.

title: [Overexpression of @entity1722 oncogene in primary @entity43 : incidence and prognostic significance in 243 XXXX ].

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancers', 'ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIMS: The phenomenon of immunosuppression induced by surgery is widely described as the adverse impact of surgical interventions on leukocytes' populations and secretion of several cytokines. Best of our knowledge, we present the first report evaluating the effect of surgical treatment on the specific anti- @entity5 immune response against @entity5 antigens. METHODS: The study included 30 @entity1 operated on for @entity2 . Specific secretion of @entity379 , @entity10807 , perforines, @entity3646 , @entity225 , @entity688 , @entity4155 was assessed by ELISPOT (Enzyme-Linked Immunosorbent Spot Assay). RESULTS: Number of cells secreting @entity379 , @entity10807 and perforines under the influence of autologous @entity5 antigens or mitogens was significantly decreased on the first day after surgery. During the postoperative recovery we observed an increase in the number of cells secreting @entity379 , but on the 7th day it still remained lower than before the operation. On the 28th postoperative day it reached a level which was not significantly higher than before the surgery. On the 1st and 7th postoperative day we discovered a significant increase in @entity688 secretion, in response to autologous @entity5 antigens. CONCLUSIONS: Our results suggest an immunosuppressive effect of surgery on the specific and nonspecific immune stimulation. This effect is particularly expressed in relation to @entity1198 -type immunological response which is associated with direct elimination of @entity5 cells. Another unfavourable observation is elevated secretion of immunosuppressive @entity688 in response to @entity5 antigens. These phenomena are associated with shorter survival of the @entity1 .

title: Surgery decreases number of cells secreting cytotoxic mediators and increases secretion of XXXX in @entity1 with @entity2 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour']

answer: @entity688 :: (3586,Gene) :: ['interleukin 10']


abstract: PURPOSE: Though various targets have been proposed and evaluated, no agent has yet been investigated in a clinical setting for @entity135 . The present study aimed to compare two fluorescently labeled anti- @entity12841 ( @entity12841 ) antibodies for detection of @entity213 ( @entity213 ). PROCEDURES: Antigen specificities and in vitro imaging of the fluorescently labeled anti- @entity12841 antibodies were performed. Next, @entity465 @entity19 (n   =   22) bearing @entity213 (OSC-19 and @entity42224 ) @entity5 received systemic injections of cetuximab-IRDye800CW, panitumumab-IRDye800CW, or IgG-IRDye800CW (a nonspecific control). @entity5 were imaged and resected using two near-infrared imaging systems, SPY and Pearl. Fluorescent lymph nodes were also identified, and all resected tissues were sent for pathology. RESULTS: Panitumumab-IRDye800CW and cetuximab-IRDye800CW had specific and high affinity binding for @entity12841 (K D   =   0.12 and 0.31  nM, respectively). Panitumumab-IRDye800CW demonstrated a 2-fold increase in fluorescence intensity compared to cetuximab-IRDye800CW in vitro. In vivo, both fluorescently labeled antibodies produced higher tumor-to-background ratios compared to IgG-IRDye800CW. However, there was no significant difference between the two in either cell line or imaging modality (OSC-19: p   =   0.08 SPY, p   =   0.48 Pearl; @entity42224 : p   =   0.77 SPY, p   =   0.59 Pearl; paired t tests). CONCLUSIONS: There was no significant difference between the two fluorescently labeled anti- @entity12841 monoclonal antibodies in @entity19 models of @entity213 . Both cetuximab and panitumumab can be considered suitable targeting agents for fluorescent intraoperative detection of @entity213 .

title: Preclinical comparison of near-infrared-labeled cetuximab and panitumumab for optical imaging of XXXX .

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

entities_list: @entity12841 :: ('13649(Tax:10090)', 'Gene') :: ['EGFR', 'epidermal growth factor receptor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tongue tumors', 'Tumors']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficient']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

answer: @entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']


abstract: Three cases of @entity81 arising in the skull base are reported. The @entity5 arose in females 34, 65, and 66 (median 55) years of age. Two @entity1 presented with @entity10 , and one with nasal obstruction. Radiographic studies revealed that all three lesions were expansile soft tissue masses centered in the clivus, at least 4 cm in greatest diameter. One lesion involved primarily the clivus, the others extended from the clivus into the sphenoid and ethmoid sinuses. Two of the three cases were initially misdiagnosed as @entity3580 or @entity511 . The initial treatment was curettage of gross disease in all three cases. One @entity1 also received radiation therapy. One @entity1 had local progression of disease, which was treated with surgery and radiation therapy. All @entity1 are clinically free of disease 11 to 26 months following the most recent treatment. @entity81 can and should be distinguished from @entity511 and @entity3580 , two @entity5 which more commonly arise in the skull base and which have the potential to metastasize.

title: XXXX of the skull base: a @entity5 which may be confused with @entity3580 and @entity511 . A report of three cases and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity81 :: ('MESH:D005350', 'Disease') :: ['chondromyxoid fibroma', 'Chondromyxoid fibroma']

answer: @entity81 :: (MESH:D005350,Disease) :: ['Chondromyxoid fibroma']


abstract: OBJECTIVE: To present a @entity1 with @entity20719 and @entity51 . This pathological entity has not been previously reported in national medical literature. BACKGROUND: @entity20719 is comprised of @entity1318 , @entity20718 and @entity1887 . It is a rare disease. Some isolated cases have been informed in the literature. The most extensive series was published by Grant et al in 1993. In this study, 20 @entity1 from various european countries were analyzed. METHOD: We describe a @entity1 with diagnosis suggestive of @entity20719 and expose the results of a review of the medical literature concerning this syndrome. We emphasize in @entity51 of these @entity1 . Such abnormalities are not actually well defined in this syndrome. RESULTS: A twelve-year-old male @entity1 was admitted to the hospital for @entity1282 . A diagnosis of @entity1318 was performed with endoscopy and esophagogram and confirmed with esophageal manometry. Physical examination showed @entity20718 and @entity51 . Stimulation of adrenal function with ACTH (Cortosin) was normal. Neurologic examination revealed: @entity1897 , @entity5433 ; corticospinal, psychomotor and @entity73 . CONCLUSION: @entity20719 must be in mind in physicians who see @entity1 with @entity1318 . Nevertheless @entity1887 is not always present in cases when diagnosis is performed. It may appear several years afterwards. @entity51 seems to be the most prominent feature.

title: [ @entity1318 , @entity20718 without XXXX with @entity51 ( @entity20719 )].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

entities_list: @entity20719 :: ('MESH:C536008', 'Disease') :: ["Allgrove's syndrome"]

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['intellectual impairment']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['peripheral and autonomic neurological dysfunction', 'neurological dysfunction', 'Neurological dysfunction']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

answer: @entity1887 :: (MESH:D000309,Disease) :: ['adrenal insufficiency']


abstract: This study aimed to estimate the relationship between various @entity14822 and @entity633 in @entity101 Korean adults. Data obtained from the Korea National Health and Nutrition Examination Survey in 2011 to 2012 were analyzed. The study included 2330 @entity101 @entity1 . Total cholesterol (TC), @entity40582 ( @entity40582 ), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels were measured. @entity2299 parameters were defined as high @entity40582 >= 200mg/dL, low HDL-C as HDL-C <40mg/dL, high TC/HDL-C as TC/HDL-C ratio >= 4, high @entity40582 /HDL-C as @entity40582 /HDL-C ratio >= 3.8, and high LDL-C/HDL-C as LDL-C/HDL-C ratio >= 2.5. @entity633 was defined as a urine albumin to creatinine ratio (ACR) >= 30mg/g. @entity1 with @entity633 showed significantly higher levels of @entity40582 , TC/HDL-C, and @entity40582 /HDL-C and a lower level of HDL-C than @entity1 without @entity633 (all P<0.05). LogTG, TC/HDL-C, and logTG/HDL-C were positively correlated with ACR in both @entity1 and @entity1 ; however, HDL-C was negatively correlated with ACR in @entity1 and non-HDL-C was positively correlated with ACR in @entity1 . In @entity1 , there was no association between ACR and lipid parameters. However, in @entity1 , higher values for logTG, TC/HDL-C, and logTG/HDL-C were associated with an increased odds ratio (OR) for @entity633 (OR [95% confidence interval]: 1.53 [1.06-2.21], 1.21 [1.02-1.45], and 1.78 [1.21-2.63], respectively) and HDL-C with a decreased OR for @entity633 (0.78 [0.67-0.92]) after adjusting for all covariates. LogTG, TC/HDL-C, and logTG/HDL-C were associated with an increased prevalence of @entity633 in @entity101 @entity1 . Screening and treatment for @entity2299 may be necessary for @entity101 @entity1 to address potential @entity633 .

title: Relationship Between @entity2299 and XXXX in @entity101 Adults: A Nationwide Population-Based Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia', 'Dyslipidemia']

entities_list: @entity14822 :: ('MESH:C562935', 'Disease') :: ['lipid abnormalities']

entities_list: @entity40582 :: ('MESH:C566031', 'Disease') :: ['TG', 'triglyceride']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria', 'Albuminuria']

answer: @entity633 :: (MESH:D000419,Disease) :: ['Albuminuria']


abstract: The aim of this review was to examine the literature on the effects of surgery of the spastic hand in @entity1 with @entity306 on functional outcome and @entity121 . We performed a search of the relevant literature in Medline, Embase, and Biological Abstracts from 1966 to June 2006. The search resulted in eight studies on the effect of surgery on functional outcome and three studies on the effect of surgery on @entity121 . Heterogeneity in outcome measures precluded meta-analysis. The studies revealed that -- at the level of impairment -- surgery has a positive effect on supination and dorsiflexion of the wrist. At the level of function, surgery might improve grip strategy and induce an increase of the repertoire of grips and spontaneous use of the hand. The evidence for the functional effects is, however, limited. Whether the possibly improved function is mediated by alterations in @entity121 patterns remains unclear. The @entity121 studies provided inconclusive results. We concluded that surgery improves the position of the hand and there are indications that it might improve hand function. Future research should address the question: does surgery improve hand function and, if so, is this due solely to a better hand position or does change in @entity121 play an additional role?

title: Does surgical management of the hand in XXXX with spastic unilateral @entity306 affect functional outcome?

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle coordination']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: The intimate synapsis of homologous chromosome pairs (homologs) by synaptonemal complexes (SCs) is an essential feature of meiosis. In many organisms, synapsis and homologous recombination are interdependent: recombination promotes @entity13654 formation and SCs are required for crossing-over. Moreover, several studies indicate that initiation of @entity13654 assembly occurs at sites where crossovers will subsequently form. However, recent analyses in budding @entity375 and @entity238 imply a special role for centromeres in the initiation of @entity13654 formation. In addition, in budding @entity375 , persistent @entity13654 -dependent centromere-association facilitates the disjunction of chromosomes that have failed to become connected by crossovers. Here, we examine the interplay between SCs, recombination, and centromeres in a @entity1 . In @entity19 spermatocytes, centromeres do not serve as @entity13654 initiation sites and are invariably the last regions to synapse. However, centromeres are refractory to de-synapsis during diplonema and remain associated by short @entity13654 fragments. Since @entity13654 -dependent centromere association is lost before diakinesis, a direct role in homolog segregation seems unlikely. However, post- @entity13654 disassembly, we find evidence of inter-centromeric connections that could play a more direct role in promoting homolog biorientation and disjunction. A second class of persistent @entity13654 fragments is shown to be crossover-dependent. Super-resolution structured-illumination microscopy (SIM) reveals that these structures initially connect separate homolog axes and progressively diminish as chiasmata form. Thus, DNA crossing-over (which occurs during pachynema) and @entity2270 remodeling appear to be temporally distinct aspects of chiasma formation. SIM analysis of the synapsis and crossover-defective mutant @entity13460   /    implies that SCs prevent unregulated fusion of homolog axes. We propose that @entity13654 fragments retained during diplonema stabilize nascent bivalents and help orchestrate local chromosome reorganization that promotes centromere and chiasma function.

title: Interplay between synaptonemal complex, homologous recombination, and centromeres during XXXX meiosis.

answer: @entity1 :: (9606,Species) :: ['mammalian']


abstract: Objective: The aim of the present study was to explore factors influencing parents' decisions to adhere and persist with @entity71 pharmacotherapy in @entity1 . Method: Focus groups (n = 3) were conducted with 16 parents recruited from metropolitan Sydney. Group discussions explored factors impacting on treatment initiation, continuation, and cessation. Focus groups were audio-recorded, transcribed verbatim, and thematically content analyzed. Results: Parents commenced and continued pharmacotherapy due to its positive impact on their @entity1 's behavior. Improvements in the @entity1 's academic performance and social interactions encouraged persistence with therapy. Parents elected to cease therapy after their @entity1 experienced side effects including appetite suppression, @entity353 , and @entity25 . Concerns about long-term effects of @entity71 medication use including potential for addiction and growth stunting, in addition to the stigma surrounding @entity71 also contributed to parents ceasing treatment. Conclusion: The findings highlight a need for the provision of accurate information about @entity71 and its treatments to parents to empower their treatment decisions and promote adherence. (J. of Att. Dis. 2013; XX(X) XX-XX).

title: Parents' Perspectives About Factors Influencing Adherence to Pharmacotherapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbances']

answer: @entity71 :: (MESH:D001289,Disease) :: ['ADHD']


abstract: OBJECTIVE: To determine the frequency of clinically relevant abnormalities missed by failure to perform a blood smear evaluation in a specific subset of @entity235 receiving chemotherapy and to compare automated and manual neutrophil counts in the same population. DESIGN: Retrospective case series. ANIMALS: 50 @entity235 receiving chemotherapy with a total nucleated cell count > 4,000 nucleated cells/ L. PROCEDURES: 50 blood smears were evaluated for abnormalities that have strong potential to change the medical plan for a @entity1 : presence of blast cells, band neutrophils, nucleated RBCs, toxic change, hemoparasites, schistocytes, and spherocytes. Automated and manual neutrophil counts were compared. RESULTS: Blood smears from 10 (20%) @entity1 had >=  1 abnormalities. Blast cells were identified on 4 (8%) blood smears, increased nucleated RBCs were identified on 5 (10%), and very mild toxic change was identified on 2 (4%). Correlation coefficient of the neutrophil counts was 0.96. Analysis revealed a slight bias between the automated and manual neutrophil counts (mean    SD difference, -0.43   10(3)/ L    1.10   10(3)/ L). CONCLUSIONS AND CLINICAL RELEVANCE: In this series of @entity1 , neutrophil count correlation was very good. @entity922 were found on 20% of the blood smears. An automated CBC appears to be accurate for neutrophil counts, but a microscopic examination of the corresponding blood smear is still recommended; further studies are needed to determine whether the detection or frequency of these abnormalities would differ dependent on chemotherapy protocol, @entity5 , and decision thresholds used by the oncologist in the ordering of a CBC without a blood smear evaluation.

title: Comparison of automated versus manual neutrophil counts for the detection of cellular abnormalities in XXXX receiving chemotherapy: 50 cases (May to June 2008).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic disease']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['Clinically relevant abnormalities']

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: A total of 1873 @entity1 admitted to a random sampling survey in 15 of the 61 administrative districts in Tanzania in 1969 has been followed up at 1 year or later. The random sample included districts with a long-established @entity378 service (A districts), those with a service of recent inception (B districts), and those with no specialized @entity378 service (C districts). The main follow-up concerns 1607 @entity1 with @entity1907 of whom 693 had a positive culture at the initial survey, 557 a negative culture and 357 had not produced a specimen. At 1 year or later 12% of the 1607 @entity1 were lost from observation, 10% were alive but with no specimen or no result, 60% were culture-negative, 5% were culture-positive, and 12% were known to be dead. The proportion of @entity1 known to be dead was similar in the 3 types of service, but the proportion lost from observation was highest in the B districts, 24% compared with 7% in the A and 10% in the C districts. Most of the losses occurred early, 73% within the first 3 months. Of the 693 @entity1 with positive culture initially 9% were culture-positive at 1 year, as were 1% of the 557 culture-negative initially. The estimated proportion culture-negative at 1 year for the @entity1 culture-positive initially was highest in the A districts, 78%, and very similar in the B and C districts, 66% and 67%, respectively. The policies of therapy were studied in 1459 @entity1 ; 86% were treated in hospital initially for a mean duration of 63 days. The standard regimen of @entity3639 , @entity8299 and @entity3109 was prescribed in 78% of the @entity1 initially, the proportions being 93% in the A, 48% in the B and 81% in the C districts. The proportion of @entity1 who received or collected supplies of medicament for the full 12 months was only 35%, the proportions being 40% in the A, 20% in the B and 39% in the C districts.

title: XXXX in Tanzania: a follow-up of a national sampling survey of drug resistance and other factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8299 :: ('MESH:D013828', 'Chemical') :: ['thiacetazone']

entities_list: @entity3639 :: ('MESH:D013307', 'Chemical') :: ['streptomycin']

entities_list: @entity3109 :: ('MESH:D007538', 'Chemical') :: ['isoniazid']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['Tuberculosis']


abstract: OBJECTIVE: In a single-center multiethnic lupus cohort, to investigate the influence of ethnicity on the prevalence of cumulative @entity149 (CNS) @entity1252 and damage, overall end-organ damage, and mortality. METHODS: Clinical features, end-organ damage, and mortality were compared by ethnic origin among @entity1 at a lupus clinic followed prospectively in a longitudinal design over a 32-year period. Statistical analysis to compare demographic features, cumulative disease manifestations, and damage included chi-square test as well as linear, logistic, and Poisson regressions adjusting for disease duration, age at diagnosis, and presence of dialysis and @entity101 . Kaplan-Meier and proportional hazard analyses were performed to compare survival. RESULTS: There were a total of 1017 @entity1 : 853 Caucasian, 88 African-Canadian, and 76 Chinese-Canadian. Age at diagnosis was younger and disease duration was shorter for Chinese-Canadians compared to Caucasians, but similar between African-Canadians and Caucasians. There was no significant difference in @entity6220 , comparing Caucasians to Chinese-Canadians. However, @entity6220 was greater in African-Canadians than Chinese-Canadians. There was no significant difference between ethnic groups in CNS damage. @entity8 was more common in African-Canadians than Caucasians, with no significant difference between Caucasian and Chinese-Canadian @entity1 . @entity8 was more common in African-Canadians and Chinese-Canadians than Caucasians. There was no significant difference in mortality among the 3 ethnic groups. CONCLUSION: In this single referral center cohort study, there was no significant difference in CNS damage or mortality among the 3 ethnic groups. African-Canadians had a higher prevalence of @entity8 and damage. Further investigation into other determinants such as genetic predisposition, treatment, and cultural perceptions is needed.

title: Ethnic variation in disease patterns and health outcomes in XXXX .

entities_list: @entity6220 :: ('MESH:D020279', 'Disease') :: ['CNS disease']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal damage', 'renal disease', 'Renal disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['renal and central nervous system']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['lupus disease']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']


abstract: BACKGROUND: @entity5441 ( @entity5441 ) is a group of disorders marked by the sustained overproduction of eosinophils, in which @entity1712 and inflammatory substance release cause damage to multiple organs. @entity2335 ( @entity2335 ) is an @entity32 caused by @entity1712 of the bladder wall. Although @entity2335 is often associated with @entity1712 , it has been rarely reported as a manifestation of @entity5441 . We report a case of @entity2335 as a primary manifestation of @entity5441 . The @entity1 was a 27-year-old male with a history of complete intracardiac repair of tetralogy of Fallot who presented with an acute onset of @entity3833 accompanied by @entity1712 (7.5 * 10(3)/ l, 60% of white blood cells). Ultrasonography and MRI of the bladder showed a bladder mass, a biopsy of which revealed @entity1712 and degranulation. METHODS: We performed a literature search in PubMed from 2001 to 2012 to find @entity1 with @entity2335 who may have had @entity5441 . RESULTS: There were 4 @entity1 with @entity5441 who had @entity2335 including the present case. Of 14 @entity1 reported as @entity2335 in whom the eosinophil count was described, 5 had eosinophils of >= 1,500/ l. None of the 5 @entity1 had secondary causes for @entity1712 . Of the 9 @entity1 with definite or probable @entity5441 , 7 @entity1 (78%) were male and 5 @entity1 (56%) showed a concomitant @entity344 . CONCLUSION: @entity5441 may not be uncommon as the cause of @entity2335 . Thorough evaluation and close monitoring are warranted in @entity2335 @entity1 with elevated eosinophils.

title: @entity2335 presented as a manifestation of XXXX : a case report and review of the literature.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disorder']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilic infiltration', 'eosinophilia']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['eosinophilic gastrointestinal disorder']

entities_list: @entity5441 :: ('MESH:D017681', 'Disease') :: ['HES', 'Hypereosinophilic syndrome']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['Eosinophilic cystitis', 'EC']

answer: @entity5441 :: (MESH:D017681,Disease) :: ['hypereosinophilic syndrome']


abstract: UNASSIGNED: A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether moderate @entity2332 @entity1167 with @entity1779 ( @entity1779 ) is more beneficial than deep hypothermic @entity1167 in elective aortic arch surgery. Altogether, 1028 papers were found using the reported search, of which 6 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, @entity1 group studied, study type, relevant outcomes and results of these papers are tabulated. There were four retrospective observational studies, one prospective randomized controlled trial and one meta-analysis study. There were no local or neuromuscular complications related to axillary arterial cannulation reported. In the elective setting, four studies showed that the in-hospital mortality for moderate @entity2332 is consistently low, ranging from 1.0 to 4.3%. In a large series of hemiarch replacement comparing 682 cases of @entity2332 with 94 cases of moderate @entity2332 with @entity1779 , 20 cases (2.8%) of permanent @entity51 were reported, compared to 3 cases (3.2%) in moderate @entity2332 . Three observational studies and a meta-analysis study did not identify an increased risk of @entity177 and dialysis following either deep or moderate @entity2332 although a higher incidence of @entity64 was reported in the meta-analysis study with @entity2332 (12.7 vs 7.3%). Longer cardiopulmonary bypass time and @entity1167 time were reported in four studies for @entity2332 , suggesting an increased time required for systemic cooling and rewarming in that group. Overall, these findings suggested that in elective aortic arch surgery, moderate @entity2332 with @entity1779 adapted to the duration of @entity1167 can be performed safely with acceptable mortality and morbidity outcomes. The risk of spinal cord and visceral organ complications is low with the use of this cerebral adjunct. Current studies did not identify an advantage in terms of @entity86 when compared with @entity2332 . The moderate @entity2332 strategy reduced operative time without increasing the mortality and morbidity of surgery.

title: Is moderate hypothermic @entity1167 with XXXX superior to deep hypothermic @entity1167 in elective aortic arch surgery?

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['postoperative renal failure']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bleeding']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['SACP', 'selective antegrade cerebral perfusion']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['deep hypothermia', 'hypothermia']

answer: @entity1779 :: (MESH:D002543,Disease) :: ['selective antegrade cerebral perfusion']


abstract: Insulin-like growth factor binding proteins (IGFBPs) are modulators of numerous cellular processes including cell proliferation. Although IGFBPs classically act by sequestration of extracellular insulin-like growth factors (IGFs), thereby contributing to the fine-tuning of growth factor signals, IGF-independent actions of IGFBPs have also been described. In the breast, growth factor signaling in association with @entity53 (E2)-stimulated @entity172 receptor function is organized in a complex cross-talk. The importance of @entity4357 3-kinase/protein kinase B ( @entity584 ) pathway components for the E2-induced activation of @entity172 receptor-alpha ( @entity1782 ) is well accepted. Here we show that in the absence of IGFs, @entity12561 or @entity14172 , either @entity0 cells or added exogenously, decreased the capability of E2 to induce @entity1782 transcriptional activity. In addition, overexpression or addition of recombinant @entity12561 or @entity14172 resulted in reduction of E2-induced phosphorylation of @entity584 , @entity35466 /b and @entity1782 in MCF-7 cells. The activation of the Akt/ @entity584 -pathway describes a non-genomic effect of E2, which did not involve activation/phosphorylation of the @entity2856 ( @entity2856 ). Furthermore, knockdown of the @entity2856 did not affect the inhibition of E2-induced @entity1782 phosphorylation by @entity31650 . Moreover, @entity12561 and @entity14172 strongly decreased E2-triggered growth of MCF-7 cells. Our data suggest that IGFBPs interfere with the E2-induced activation of the Akt/ @entity584 -pathway and prevent full hormone-dependent activation of @entity1782 and @entity0 cell growth in an IGF- and @entity2856 -independent manner.

title: Insulin-like growth factor binding protein-4 and -5 modulate ligand-dependent @entity172 receptor-a activation in XXXX cells in an IGF-independent manner.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'overexpressed in MCF-7 breast cancer']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity4357 :: ('MESH:D010716', 'Chemical') :: ['phosphatidylinositol']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: The utility of @entity419 (FDG) positron emission tomography (PET) in @entity1697 has received little attention in a clinician's perspective. We systematically evaluated the clinical roles of FDG PET in @entity1 with oral @entity1544 ( @entity957 ). METHODS: Between August 2001 and February 2005, 82 new @entity1 with resectable oral cavity @entity957 underwent CT/MRI and FDG PET at initial staging and follow-up. The sensitivity and specificity of CT/MRI and FDG PET for neck metastases were compared with histopathologic reference of 67 @entity1 who underwent neck dissection. The relationships between the maximal standardized uptake value (SUV) of @entity5 and clinicopathologic parameters, such as gender, age, @entity5 thickness, local invasiveness, T and N categories, @entity5 -node- @entity3 stage, and histological grade, as well as with disease-free survival (DFS), were assessed. RESULTS: FDG PET was more sensitive than CT/MRI for detecting cervical metastases on a level-by-level basis (38/43 vs. 28/43; P=0.002). Age, T and N categories, @entity5 thickness (>8mm) and SUV (>5.0) were also significant variables of 3-year DFS in univariate analysis. T category was an independent determinant of DFS in multivariate analysis (P<0.05). During a mean follow-up of 36 months, FDG PET correctly diagnosed locoregional recurrences in 20 @entity1 , distant metastases in six and second @entity5 in five. CONCLUSION: FDG PET may have potential roles in initial staging, survival prediction, and the detection of recurrences and second @entity5 .

title: Utility of FDG PET in XXXX with @entity957 of the oral cavity.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-fluorodeoxyglucose']

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral cavity cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'cancers']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['cavity squamous cell carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Sleep problems and disorders are prevalent in @entity131 and are associated with negative outcomes. Incidence varies due to challenges including differences in assessment methods particularly in acute stages of recovery when @entity1 are cognitively impaired and unable to complete traditional self-report methods. Actigraphy (ACG) has recently been validated in the acute @entity131 rehabilitation setting and may serve as a superior method of assessing sleep-wake patterns at this stage of recovery. Although a few studies with small sample sizes have described using ACG, none have described feasibility and implementation protocols. OBJECTIVE: To describe the feasibility and implementation protocol of actigraphy to evaluate sleep-wake patterns and white-light exposure data in @entity1 with acute @entity131 during inpatient rehabilitation. Sleep-wake patterns and light exposure data are presented in order to characterize the sample using these methods to inform future research. DESIGN: Retrospective Study SETTING: Acute Inpatient Rehabilitation Unit at a VA Polytrauma Rehabilitation Center @entity1 : Veterans (age >= 18) admitted to inpatient rehabilitation and enrolled in the @entity131 ( @entity131 ) study who were admitted and discharged in the calendar year 2013. METHODS: Veterans underwent actigraph watch placement as soon as possible after admission. Records from the calendar year 2013 were reviewed to determine the number of admissions that met study criteria and what percentage of those @entity1 had three days of continuous ACG data collected. The barriers to successful watch placement in this population were reviewed. Average sleep, light, and wake data from available records were collected for the study sample. MAIN OUTCOME MEASUREMENTS: Percentage of @entity1 who met study criteria and who had 72 hours of continuous ACG data collected. The barriers to successful watch placement in this population were reviewed. Average sleep, light, and wake data from available records were collected. RESULTS: Of 22 eligible @entity131 admissions, three consecutive nights of ACG data were successfully obtained for 86% (n = 19) of the sample. Barriers to data collection included @entity1 access due to abbreviated lengths of stay, staff availability for ACG placement, and data collection protocols to prevent loss of data in VA computing systems. CONCLUSIONS: ACG is feasible for collecting data about sleep, wake, and light exposure in @entity1 who are in acute @entity131 inpatient rehabilitation settings.

title: Implementation of Actigraphy in Acute @entity131 Neurorehabilitation Admissions: A Veterans Administration XXXX Model Systems Feasibility Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['Traumatic Brain Injury Model Systems', 'TBIMS', 'TBI']

answer: @entity131 :: (MESH:D001930,Disease) :: ['TBI']


abstract: -catenin can affect cytoskeletal assembly, and promote cell migration by regulating the activity of small GTPases. While many ma @entity5 ave been shown to be positive for   -catenin, it is still unclear whether   -catenin and small GTPases are coexpressed in tu @entity5 ells, and so is the relationship between their coexpression and prognosis in the tu @entity5 a @entity1 In this study, immunohistochemistry was performed to examine expressive levels of   -catenin, cd @entity5605 and Ra @entity5180 n 135 cases of no @entity1149 NS @entity1149 including 60 cases with follow-up records. Thirty samples of pa @entity2 issues and adjacent normal lung tissues were collected to analyze mRNA and protein expression of   -catenin and small GTPases. The effects of   -catenin on small GTPases expression and invasive ability of lu @entity2 ells were also evaluated. Compared with normal lung tissues, both mRNA and protein levels of   -catenin and small GTPases were in @entity2 issues (P < 0.05), and the expression of small GTPases directly correlated with that of   -catenin (P < 0.001). In addition,   -catenin and small GTPases tended to be co @entity2220 advanced stages, and pr @entity5 ith lymph node me @entity3 all P < 0.05). The pa @entity1 ith coexpression of   -catenin and small GTPases had a shorter survival time than those without coexpression (P < 0.05). Furthermore,   -catenin overexpression could enhance invasive ability of lu @entity2 ells by upregulating protein and transcriptional level of small GTPases. Therefore,   -catenin likely upregulates the activity of small GTPases at transcriptional level, and their coexpression may predict a poor clinical outcome in NS @entity1149 a @entity1

title: Overexpression of small GTPases directly correlates with expression of   -catenin and their coexpression predicts a poor clinical outcome in XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'malignancies']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'nonsmall cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['paired lung cancer', 'increased in lung cancer', 'lung cancer']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['coexpressed in lung adenocarcinoma']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['nonsmall cell lung cancer']


abstract: AIMS: To review the outcome of @entity1 with @entity189 of the skin of the @entity135 with perineural infiltration (PNI) with clinical features treated with radiotherapy. MATERIALS AND METHODS: Between 1991 and 2004, 56 @entity1 with @entity1489 with PNI with clinical features were identified from the institution's oncology database. All @entity1 had radiotherapy as either definitive or adjuvant treatment. The factors that affected outcome were analysed. The primary end point was the 5 year relapse-free survival (RFS) from the time of diagnosis of PNI. RESULTS: The overall 5 year RFS for the whole group was 48%. Squamous histology had a more unfavourable outcome than basal cell histology (5 year RFS: 39% versus 80%; P = 0.07). Tumours located in the distribution of the cranial nerves V1 and V2 had a worse outcome than @entity5 at other sites (5 year RFS: 33% versus 72%, P = 0.056). Those with multiple cranial nerve involvement did worse than those with single nerve involvement (27% versus 62%, P = 0.1). The pattern of relapse was predominantly local (87%), with a low rate (15%) of successful salvage. CONCLUSION: Radiotherapy with or without surgery is curative in about half @entity135 cutaneous @entity189 with clinical PNI. The frequent local failure suggests that improvements in local treatment are required.

title: @entity189 of the XXXX with clinical features of perineural infiltration treated with radiotherapy.

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanomatous skin carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['non-melanomatous carcinomas', 'non-melanomatous carcinoma']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck']


abstract: Three transmembrane @entity367 residues play essential roles in the metal- @entity803 /H+ antiporter Tet(K) of @entity794 [Fujihira et al., FEBS Lett. 391 (1996) 243-246]. In the putative hydrophilic loop region of the Tet(K) and Tet(L) proteins, six acidic residues are conserved. @entity2574 74, @entity2574 200, @entity2574 318 and @entity367 381 are located on the putative cytoplasmic side, and @entity2574 39 and @entity367 345 on the putative periplasmic side. These residues were replaced by a neutral @entity535 residue or a charge-conserved one. In contrast to the transmembrane @entity367 residues, the replacement of the two @entity367 residues ( @entity367 345 and @entity367 381) did not affect the @entity803 resistance level. Out of the other four @entity2574 residues, the only essential residue is @entity2574 318, any replacement of which resulted in complete loss of the @entity803 resistance and transport activity. @entity2574 318 is located in cytoplasmic loop 10-11 in the putative 14-transmembrane-segment topology of Tet(K). In the case of the @entity803 exporters of Gram-negative bacteria, the only essential acidic residue in the cytoplasmic loop region is located in loop 2-3 [Yamaguchi et al., Biochemistry 31 (1992) 8344-8348]. It may be a general role for @entity803 efflux proteins that three transmembrane and one cytoplasmic acidic residues are mandatory for the @entity803 transport function.

title: Roles of acidic residues in the hydrophilic loop regions of metal- @entity803 /H+ antiporter Tet(K) of XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity367 :: ('CHEBI:18237', 'Chemical') :: ['glutamic acid', 'Glu']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['Asp', 'aspartic acid']

answer: @entity794 :: (1280,Species) :: ['Staphylococcus aureus']


abstract: INTRODUCTION: @entity5506 ( @entity5506 ) is defined as the increased destruction of red blood cells (RBCs) in the presence of anti-RBC autoantibodies and/or complement. Its pathogenesis is multifactorial and includes changes in mechanisms of cytokine production and functionality. A number of recent studies have implicated cytokines polymorphisms in the pathogenesis of @entity792 . The aim of this study was to determine the frequency of polymorphisms of @entity5 necrosis factor alpha ( @entity310 ), @entity4909 ( @entity4909 ), @entity688 ( @entity688 ), interleukin 12 (IL-12) and @entity4386 ( @entity4386 ) in @entity1 with @entity5506 in comparison with healthy individuals. METHODS: The study population consisted of 17 @entity1 with @entity5506 and 40 healthy controls. The polymorphisms for @entity310 -308, @entity4909 +252, @entity688 -592, IL-12 +1188 and @entity4386 +49 were examined by polymerase chain reaction followed by specific restriction enzyme digestion. RESULTS: There was no significant difference in the phenotypic distributions of polymorphisms of the @entity310 , @entity688 , IL-12 and @entity4386 between the @entity1 and controls. Compared with healthy controls, @entity1 with @entity5506 had a significant higher frequency of @entity4909 (+252) AG phenotype (41%vs. 13%; P = 0.032). CONCLUSION: In this study, no significant differences on the frequency of @entity310 , @entity688 , IL-12 and @entity4386 polymorphisms between @entity1 with @entity5506 and controls was found, suggesting that the targeted polymorphisms do not influence on the emergence and evolution of the disease. However, the @entity4909 +252 polymorphism might have an effect for AIHAI development, suggesting that further studies are necessary to clear up this question.

title: Analysis of polymorphisms of @entity310 , @entity4909 , @entity688 , IL-12 and @entity4386 in XXXX with warm autoimmune haemolytic anaemia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity5506 :: ('MESH:D000744', 'Disease') :: ['Autoimmune haemolytic anaemia', 'AIHA']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

entities_list: @entity4386 :: ('1493', 'Gene') :: ['cytotoxic T-lymphocyte antigen-4', 'CTLA-4']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The @entity1 @entity5 clonogenic assay (HTCA) and the @entity1 @entity5 xenograft system implanted in @entity19 were performed simultaneously in an @entity43 @entity1 as chemosensitivity testing. Eight anticancer drugs ( @entity1487 , @entity1139 , VCR, @entity13685 , BLM, VLB, CDDP, and ADM) were applied to the HTCA and the @entity1 @entity5 xenograft system. In the HTCA, @entity1487 and @entity1139 were sensitive, VCR was moderately sensitive, and @entity13685 , BLM, VLB, CDDP, and ADM were resistant. In the @entity1 @entity5 xenograft system, @entity1139 , VCR, and ADM showed @entity5 regression (++), and CDDP, VLB, BLM, @entity1487 , and @entity13685 exhibited no response (-). Two of the three drugs, which were classified as sensitive or intermediately sensitive in the HTCA, showed @entity5 regression (++) in the @entity1 @entity5 xenograft system. And four of the five drugs, which were resistant in the HTCA, exhibited no response (-) in the @entity1 @entity5 xenograft system. Clinically, PVB therapy (CDDP, VLB, and BLM) was applied to the present @entity1 , but after recurrence, @entity1487 + @entity1139 therapy was applied on the basis of the results of the HTCA. In addition, ADM was added with reference to the results of the @entity1 @entity5 xenograft system. As a result of this therapy, the @entity5 growth was inhibited. It is possible from the present data that simultaneous chemosensitivity testing of the HTCA and the @entity1 @entity5 xenograft system implanted in @entity19 is very useful when choosing sensitive anticancer drugs.

title: [Chemotherapy of @entity43 based on in vitro (HTCA) and in vivo ( XXXX ) chemosensitivity testing].

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

answer: @entity19 :: (10090,Species) :: ['nude mice']


abstract: @entity21168 isolates associated with recent outbreaks of @entity1576 in Ontario and Quebec dairy farms were compared to reference strains known to be responsible for neonatal calf @entity294 (NCD) or @entity5163 ( @entity5163 ) of adult @entity291 . In respect to their hemagglutinating properties and their higher RDE activities with @entity35 erythrocytes, WDBCoV strains differed from NCDBCoV strains and respiratory @entity291 coronaviruses RBCoV strains. Serologically, three MAbs directed to the HE glycoprotein of the WDBCoV strain BCQ.2590 recognized two serogroups amongst NCDBCoV strains by hemagglutination inhibition, whereas only one of the MAbs failed to react toward three of the four RBCoV isolates tested. Sequencing analysis of the S (S1 portion), HE, ORF4 and ORF5 genes of BCoV isolates associated with different clinical syndromes indicated that neither insertions or deletions could explain their distinct tropism. For the HE glycoprotein, a total of 15 @entity1522 (aa) substitutions were identified by comparing field isolates to the prototype Mebus strain. Two specific @entity1521 substitutions were identified for virulent strains being located in the signal peptides (aa 5) and aa position 367; one specific aa change was revealed at position 66 for RBCoV field isolates. Analysis of the S1 portion of the S glycoprotein revealed a total of eight aa changes specific to enteropathogenic (EBCoV) strains and eight aa changes specific to RBCoV strains. For all BCoV isolates studied, the region located between the S and M genes (ORF4) apparently encodes for two non-structural (ns) proteins of 4.9 and 4.8 kDa. A specific non-sense mutation was identified for the @entity377 at position 88 of the putative 4.9 kDa protein gene of RBCoV isolates resulting in 29 rather that 43 aa residues. The ORF5, which encodes a 12.7 ns protein and the 9.5 kDa E protein, was highly conserved amongst the BCoV field isolates.

title: @entity291 coronaviruses associated with enteric and @entity1576 in Canadian dairy XXXX display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity21168 :: ('11128', 'Species') :: ['Bovine coronavirus']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity5163 :: ('MESH:D004403', 'Disease') :: ['WD', 'winter dysentery']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: Introduction. @entity810 ( @entity810 ) is a common occurrence in the intensive care unit (ICU). Studies have looked at outcomes of renal replacement therapy using @entity400 ( @entity400 ) in ICUs with varying results. Little is known about the outcomes of using @entity400 in resource-limited settings where continuous renal replacement therapy (CRRT) is limited. We sought to determine outcomes of @entity400 among @entity3124 @entity1 admitted to a low-income country ICU. Methods. A retrospective review of @entity1 records was conducted. @entity1 admitted to the ICU who underwent @entity400 for @entity810 were included in the study. @entity1 ' demographic and clinical characteristics, cause of @entity810 , laboratory parameters, haemodialysis characteristics, and survival were interpreted and analyzed. Primary outcome was mortality. Results. Of 62 @entity1 , 40 had complete records. Median age of @entity1 was 38.5 years. Etiologic diagnoses associated with @entity810 included @entity295 , @entity311 , and @entity649 . Mortality was 52.5%. APACHE II (OR 4.550; 95% CI 1.2-17.5, p = 0.028), mechanical ventilation (OR 13.063; 95% CI 2.3-72, p = 0.003), and need for vasopressors (OR 16.8; 95% CI 3.4-82.6, p = 0.001) had statistically significant association with mortality. Conclusion. @entity400 may be a feasible alternative for RRT in @entity3124 haemodynamically stable @entity1 in low resource settings where CRRT may not be available.

title: Clinical Characteristics and 30-Day Outcomes of Intermittent Hemodialysis for XXXX in an African Intensive Care Unit.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill']

entities_list: @entity400 :: ('MESH:D014202', 'Disease') :: ['intermittent haemodialysis', 'IHD']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'Acute kidney injury']

answer: @entity810 :: (MESH:D058186,Disease) :: ['Acute Kidney Injury']


abstract: We set out to determine whether inhibition of complement using sCR1 could influence the development and progression of @entity1753 in the Lewis @entity35 . Collagen @entity625 was successfully established in the Lewis @entity35 , using a novel immunization schedule. In separate experiments, cobra venom factor (CVF) and sCR1 were used to achieve systemic complement inhibition. Their respective effects on disease onset and on the progression of @entity66 compared with saline-treated control animals was explored. @entity625 was assessed by measurement of clinical score, paw diameter and paw volume. Complement inhibition using either CVF or sCR1, prior to the onset of clinical signs of @entity32 , delayed the development of disease. CVF was ineffective in the treatment of @entity66 , whereas sCR1 delayed the @entity74 in affected joints and prevented the @entity2720 while the animals were complement-depleted. In the control saline-treated groups the disease continued to progress relentlessly. We conclude that complement activation is important in the initiation and maintenance of @entity32 in @entity1753 . The potent disease-modulating effect of sCR1 provides persuasive evidence that specific complement inhibiting agents may be an effective approach to the treatment of inflammatory joint diseases

title: Soluble complement receptor one (sCR1) inhibits the development and progression of @entity35 collagen-induced XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis', 'Arthritis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['established disease']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen arthritis']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['progression of disease']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['recruitment of further joints']

answer: @entity625 :: (MESH:D001168,Disease) :: ['arthritis']


abstract: BACKGROUND: Comminuted @entity174 of the radial head are challenging to treat with open reduction and internal fixation. Radial head arthroplasty is an alternative treatment with results that compare favorably with those reported after open reduction and internal fixation of similar @entity174 . The purpose of this study was to evaluate the two-year outcomes and the rate of recovery of a closely followed cohort of @entity1 in whom an unreconstructible @entity174 had been treated with a modular metallic prosthesis. METHODS: Twenty-six @entity1 (seventeen female and nine male; mean age, fifty-four years) with an unreconstructible comminuted @entity174 and associated @entity130 were treated with a modular metallic radial head arthroplasty. @entity1 who had presented more than four weeks following the injury or had had the radial head arthroplasty as a second-stage or salvage procedure were excluded. Of the twenty-six @entity1 , twenty-two had an associated @entity3029 , and thirteen of them also had an associated @entity174 of the coronoid process. @entity1 were prospectively followed at three, six, twelve, and twenty-four months. Self-reported limb function, general health, range of motion, and isometric strength were assessed by an independent observer. RESULTS: Following treatment of the injury, significant decreases in self-reported and measured impairments were noted over time, with the majority of the recovery occurring by six months and little further recovery noted between six and twenty-four months. There were slight-to-moderate @entity51 and strength compared with the values on the contralateral, unaffected side. @entity1 satisfaction was high at three months and remained high at two years. All @entity2720 remained stable, no implant required revision, and there was no evidence of overstuffing of the joint. Mild @entity571 was seen in five (19%) of the twenty-six @entity1 . CONCLUSIONS: An arthroplasty with a modular metallic radial head is a safe and effective option for the treatment of unreconstructible radial head @entity174 associated with other @entity130 . Recovery primarily occurs by six months, with minimal additional improvements over the next eighteen months.

title: Comminuted radial head XXXX treated with a modular metallic radial head arthroplasty. Study of outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'radial head fracture', 'fracture']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['deficits in the range of motion']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['elbow joints']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['elbow injuries']

entities_list: @entity3029 :: ('MESH:D004204', 'Disease') :: ['elbow dislocation']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: BACKGROUND: Although @entity4 is one of the common findings of @entity7375 , severe @entity227 from @entity1781 involvement is not common. We report a case of severe visual field contraction from @entity1781 involvement in @entity7375 . CASE REPORT: A 51-year-old @entity1 was diagnosed as having @entity7375 and was treated with intravenous pulse @entity1667 . Exudative @entity1713 disappeared and visual acuity improved, but @entity4 was persistent in both eyes. Ten weeks after @entity7375 onset, she claimed acute visual field @entity735 . Marked @entity4 with @entity548 and severe @entity227 were observed in the right eye. @entity941 angiography showed filling delay and late leakage of the @entity1781 in the right eye. One month later, right @entity4 disappeared, but @entity227 remained. In addition, 5.5 months later, the left @entity1781 swelled further, and the left visual field was markedly contracted. Hyperbaric @entity26 therapy was added. The swelling in the left @entity1781 gradually decreased and disappeared in one month, but the @entity227 remained. CONCLUSIONS: The @entity1781 involvement with irreversible @entity227 in this case is thought to be due to @entity6810 , which may be a possible complication of @entity7375 .

title: [A case of @entity6810 associated with XXXX ].

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field loss']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['peripapillary hemorrhages']

entities_list: @entity6810 :: ('MESH:D018917', 'Disease') :: ['anterior ischemic optic neuropathy']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['retinal detachments']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['optic disc swelling']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['loss in the right eye']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic disc']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein']

entities_list: @entity7375 :: ('MESH:D014607', 'Disease') :: ['VKH disease', 'Vogt-Koyanagi-Harada (VKH) disease']

answer: @entity7375 :: (MESH:D014607,Disease) :: ['Vogt-Koyanagi-Harada disease']


abstract: To report the successful surgical excision of well-circumscribed @entity8702 of the eyelid and orbit inducing @entity432 in 2 cases with immediate improvement of the @entity1 's symptoms. A 2-month-old @entity1 was diagnosed with a @entity5 which was removed intact via an inferior transconjunctival orbitotomy after magnetic resonance imaging (MRI) revealed a well-defined mass filling the entire inferior orbit. Histopathologic examination confirmed the diagnosis of orbital @entity8702 . A 1-month-old @entity1 developed @entity432 due to an enlarging subcutaneous @entity5 . The discrete mass was excised via an eyelid crease approach and confirmed to be an eyelid @entity8702 . There were no short-term or long-term complications in either case. In both cases, immediate resolution of @entity432 and cosmetic disfiguration was achieved. The final visual acuities were 20/20 at 5 years in the first @entity1 and 20/30 at 4 years follow-up in the second @entity1 . Orbital and eyelid @entity8702 can induce profound permanent @entity4457 . If the @entity5 is well-circumscribed, confirmed with orbital imaging, then surgical excision, with immediate resolution of amblyogenic factors, can be considered as a treatment option.

title: Surgical excision of selected amblyogenic periorbital XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['massive, amblyogenic orbital tumor', 'tumor', 'tumor of the left upper eyelid']

entities_list: @entity8702 :: ('MESH:D018324', 'Disease') :: ['capillary hemangioma', 'capillary hemangiomas']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion amblyopia']

entities_list: @entity4457 :: ('MESH:D000550', 'Disease') :: ['amblyopia']

answer: @entity8702 :: (MESH:D018324,Disease) :: ['capillary hemangiomas']


abstract: BACKGROUND: A study was conducted to investigate the clinicopathological features and survival outcomes of @entity674 ( @entity674 ) that are synchronous with other @entity1820 . METHODS: Clinical and pathological data of 286 @entity1 with primary @entity677 from a single institution from January 2009 to December 2014 were reviewed. RESULTS: The entire study population comprised 286 @entity1 with @entity674 . Of these @entity1 , 167 (58.4%) were males and 119 (41.6%) were females. The median age was 58 years old (in the range 29-86 years). A total of 47 @entity1 were diagnosed with @entity674 synchronous with other digestive tract @entity5 (synchronous group), whereas 239 @entity1 were diagnosed with @entity7158 (non-synchronous group). The concomitant digestive tumors in 27, 12, 7, and 1 @entity1 were diagnosed as @entity356 , @entity418 , @entity14 , and @entity788 , respectively. Compared with the synchronous group, the non-synchronous group exhibited a higher percentage of increased mitotic count (P   =   0.011). The difference in @entity5 diameter between the two groups was statistically significant (P   <   0.001). @entity1 in the non-synchronous group exhibited @entity5 size than the @entity1 in the synchronous group (5.9        3.5 cm vs. 1.6        0.4 cm, P   <   0.001). The majority of @entity75 in the synchronous group were located in the stomach (P   =   0.020). Lower risk stratifications and worse ECOG performance statuses were observed in the synchronous group (P   <   0.001) than in the non-synchronous group. The 5-year overall survival rate was significantly higher in @entity1 with no synchronous digestive tract @entity5 than in @entity1 with @entity66 (70.8 vs. 34.1%, P   <   0.001). CONCLUSIONS: @entity1 with @entity677 synchronous with other @entity1820 show worse prognosis than those with @entity5 . Clinicians should pay more attention to this subgroup.

title: Synchronous XXXX and @entity674 : a single-institution experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma']

entities_list: @entity7158 :: ('MESH:D009378', 'Disease') :: ['non-synchronous disease']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['synchronous disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'non-synchronous tumors', 'larger tumor', 'malignancies']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['GIST lesions']

entities_list: @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['GISTs', 'gastrointestinal stromal tumors']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma']

answer: @entity1820 :: (MESH:D005770,Disease) :: ['gastrointestinal cancer']


abstract: One hundred two @entity1 , aged 0.7 to 38 years, with a wide variety of @entity299 underwent the Fontan operation (1975 to April, 1985). Several different techniques were used. All but 17 had previously undergone one or more palliative operations. Follow-up information was obtained in all @entity1 . Overall actuarial survival rate, with time zero being the time of the operation, was 63% at 6 years with no deaths after that in @entity1 followed as long as out to 9.4 years; that for @entity1 with @entity1145 was 81%. The hazard function (instantaneous risk) for @entity204 was highest immediately after operation and merged after about 6 months with a constant hazard extending as long as the @entity1 were followed. Elevated post-repair right atrial pressure was correlated (p = 0.002) with the probability of @entity204 in the early phase, with the risk rising rapidly with pressures above 14 mm Hg. @entity1184 of the ventricular main chamber was a risk factor for @entity204 in both the early (p = 0.007) and late (p = 0.008) phases of hazard, which explained in part the lesser risk of the Fontan operation in @entity1 with @entity1145 . Younger age, but not older age, was a risk factor for early @entity204 , but this risk was neutralized by recent date of operation. Thus currently there is not a predicted increased risk associated with younger age at operation. In general, the Fontan operation should be done at a young age (2 to 4 years) to avoid increasing @entity123 , but older age per se is not a contraindication to the operation.

title: The Fontan operation. XXXX , age, and date of operation as risk factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['Hypertrophy']

entities_list: @entity1145 :: ('MESH:D018785', 'Disease') :: ['tricuspid atresia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac malformations']

entities_list: @entity123 :: ('MESH:D024741', 'Disease') :: ['ventricular hypertrophy']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['postoperative death', 'death']

answer: @entity123 :: (MESH:D024741,Disease) :: ['Ventricular hypertrophy']


abstract: AIM: Adherence to and the applicability of practice guidelines for the management of @entity157 ( @entity157 ) in field practice have not been fully addressed. We designed a multicenter field practice prospective study to evaluate the adherence to the 2005 American Association for the Study of @entity409 guidelines in Italy. MATERIALS _ METHODS: The study began in September 2008 and consecutively enrolled cirrhotic @entity1 with newly diagnosed @entity157 from 30 local, nonreference centers in Italy. @entity1 were stratified according to @entity1 -Pugh, the model for @entity3851 , @entity5 -node metastasis, performance status and the @entity96 ( @entity96 ) classifications. The diagnostic and therapeutic strategies adopted in each individual @entity1 were recorded. Statistical analysis was carried out on 536 @entity1 using all of the valuable data. RESULTS: A total of 286 (54.5%) @entity1 were >= 70 years old. Comorbidities, recorded in 397 (74%) @entity1 , were classified as moderate to severe in 170 @entity1 (43%). Overall, 174 (59%) @entity1 with early-stage @entity96 were >= 70 years; 104 (35%) of these had moderate-to-severe comorbidities and 54% were under a regular US surveillance program. Diagnosis was performed by computed tomography in 93% of @entity1 , contrast-enhanced ultrasound in 62% and MRI in 17%. In @entity1 with nodules of  <=2 cm, adherence to noninvasive diagnostic criteria was 56%. Adherence to the @entity96 classification was shown to be suboptimal overall, particularly regarding allocation to surgical procedures, and a total of 119 @entity1 (40%) with @entity96 stage A did not receive curative therapies. CONCLUSIONS: This multicenter survey showed that, in the 'real world', adherence to the both the diagnostic and therapeutic American Association for the Study of @entity409 2005 algorithms was low, particularly in @entity1 with early-stage @entity157 . Difficulties in applying the algorithms in routine clinical practice and the high prevalence of older @entity1 with relevant comorbidities may account for our findings. Strategies to help improve adherence to international guidelines for @entity157 in field practice are required.

title: Adherence to American Association for the Study of XXXX guidelines for the management of @entity157 : results of an Italian field practice multicenter study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients', 'patient']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['Barcelona Clinic Liver Cancer', 'BCLC']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver Diseases']

entities_list: @entity3851 :: ('MESH:D058625', 'Disease') :: ['end-stage liver disease']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity409 :: (MESH:D008107,Disease) :: ['Liver Diseases']