abstract: The aim of this article is to describe a community-based multi-modality intensive treatment program, which demonstrates a significant @entity1277 while providing an opportunity to deal with the functional and social skills. Treatment is delivered through a multidisciplinary team. The uniqueness of the team is in the inclusion of clinical mentors. These are social workers, art therapists and graduate level psychology students who are trained to connect with clients in an informal, intensive manner (10-40 hours a week). The mentors focus on legitimizing healthy attitudes to food, eating and life, while highlighting the @entity158 and loss associated with the disorder. The mentors serve as meal companion and calming figure, representing the healthy self-caring voice. The relationship established during the many hours spent together becomes a powerful experience, completely different from the isolation of the disorder. The treatment intervenes in most areas of life, focusing on an active search for possibilities, in contrast to the emptiness associated with the disorder. This article presents the results and principles of a 2.5-year practice. Seventeen @entity1 , ill for 6 years and more, completed this program more than a year ago. An assessment of their BMI and their general outcome using Eckert scales was performed. One year after completing the program, 76% of the @entity1 were defined as recovered and 12% were almost recovered with only a few remaining symptoms. All of these @entity1 function satisfactorily in the community, both in social and occupational aspects. Six percent were partially recovered and 6% suffered from regression during the first year of follow-up. This treatment provides the intensity required in hospitalizations, while enabling @entity1 to stay in the community and maintain those activities that survive the disorder. This program has proven to work well with chronic @entity1 . Further data, not analyzed as yet, also indicates the efficacy of this treatment in acute cases.

title: [Clinical mentorship as a bridge to life in the treatment of XXXX ].

entities_list: @entity1277 :: ('MESH:D001068', 'Disease') :: ['reduction in symptoms of eating disorders']

answer: @entity1277 :: (MESH:D001068,Disease) :: ['eating disorders']


abstract: Functional brain imaging studies have provided insights into the processes related to motor recovery after @entity64 . The comparative value of different motor activation tasks for probing these processes has received limited study. We hypothesized that different hand motor tasks would activate the brain differently in controls, and that this would affect control- @entity1 comparisons. Functional magnetic resonance imaging (MRI) was used to evaluate nine control subjects and seven @entity1 with good recovery after a left hemisphere @entity64 . The volume of activated brain in bilateral sensorimotor cortex and four other motor regions was compared during each of three tasks performed by the right hand: index-finger tapping, four-finger tapping, and squeezing. In control subjects, activation in left sensorimotor cortex was found to be significantly larger during squeezing as compared with index-finger tapping. When comparing control subjects with @entity64 @entity1 , @entity1 showed a larger volume of activation in right sensorimotor cortex during index-finger tapping but not with four-finger tapping or squeezing. In addition, @entity1 also showed a trend toward larger activation volume than controls within left supplementary motor area during index-finger tapping but not during the other tasks. Motion artifact was more common with squeezing than with the tapping tasks. The choice of hand motor tasks used during brain mapping can influence findings in control subjects as well as the differences identified between controls and @entity64 @entity1 . The results may be useful for future studies of motor recovery after @entity64 .

title: A functional MRI study of three motor tasks in the evaluation of XXXX recovery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'hemiparetic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: T-cell @entity706 of the gastrointestinal tract is rare. The genotype of @entity784 remains unclear. The aim of this study was to elucidate the pathogenesis of a case of primary @entity784 by using cytogenetics and molecular biology. Gastric biopsy specimens and @entity706 cells in the @entity843 were examined by immunocytology, cytogenetic analysis, and Southern blot analysis. The histological diagnosis of the @entity6595 was diffuse large cell type. T-cell markers were positive in immunocytochemistry of the @entity6595 cells and in FACS analysis of @entity706 cells in the @entity843 . All @entity706 cells in the @entity843 had complex abnormal karyotypes containing t(8;14)(q24;q32). Southern blot analysis revealed rearrangement of the @entity7513 and @entity517 genes of the @entity706 cells in both the stomach and the @entity843 , but no comigration of the @entity517 with the @entity12808 locus could be detected. The TCR-beta and -gamma genes were in their germ-line configurations. In this @entity1 , although the phenotype was @entity784 , the karyotype t(8;14)(q24;q32) and genotype had the characteristics of @entity1892 . The unique B-cell genotype configuration and the @entity517 activation suggested that the cellular origin of this rare case of @entity706 with a T-cell phenotype was quite immature lymphocytes.

title: Genotype configuration in a case of primary XXXX with T-cell phenotype.

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'malignant lymphoma']

entities_list: @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric lymphoma']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['gastric T-cell lymphoma', 'T-cell lymphoma']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma']

answer: @entity6595 :: (MESH:C535648,Disease) :: ['gastric lymphoma']


abstract: Application of SEREX (serological analysis of recombinant @entity5 cDNA expression libraries) to different @entity5 types has led to the identification of several categories of human @entity5 antigens. In this study, the analysis of a @entity0 library with autologous patient serum led to the isolation of seven genes, designated @entity52777 through NY-BR-7. @entity52777 , representing 6 of 14 clones isolated, showed tissue-restricted mRNA expression in breast and testis but not in 13 other normal tissues tested. Among @entity5 specimens, @entity52777 mRNA expression was found in 21 of 25 @entity0 but in only 2 of 82 nonmammary @entity5 . Structural analysis of @entity52777 cDNA and the corresponding genomic sequences in the recently released working draft of @entity1 genome indicated that @entity52777 is composed of 37 exons and has an open reading frame of 4.0-4.2 kb, encoding a peptide of Mr 150,000-160,000. A bipartite nuclear localization signal motif indicates a nuclear site for @entity52777 , and the presence of a bZIP site (DNA-binding site followed by @entity368 zipper motif) suggests that @entity52777 is a transcription factor. Additional structural features include five tandem ankyrin repeats, implying a role for @entity52777 in protein-protein interactions. @entity52777 thus represents a breast tissue-specific putative transcription factor with autoimmunogenicity in @entity0 @entity1 . In addition to @entity52777 , a homologous gene, @entity52778 , was identified in this study. @entity52778 shares 54% @entity535 homology with @entity52777 and also shows tissue-restricted mRNA expression. However, unlike @entity52777 , @entity52778 mRNA is expressed in brain, in addition to breast and testis. The exon structure of @entity52778 remains to be defined. Using @entity1 genome database, @entity52777 was localized to chromosome 10p11-p12, and @entity52778 was tentatively localized to chromosome 9.

title: Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a XXXX library.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer']

entities_list: @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: AIMS: To determine whether @entity2449 pretreatment has beneficial effects in @entity4082 resistant infertile @entity1 with @entity3610 ( @entity3610 ) in an @entity249 clinic. METHODS: This was a randomized placebo controlled double-blind crossover study of 3 months @entity2449 (1500 mg day-1)/placebo, followed by 3 months @entity2449 /placebo together with @entity4082 (50-100 mg for 5 days) for three cycles in @entity4082 resistant @entity1 with @entity3610 . The primary outcomes were restoration of spontaneous menses, ovulation induction (spontaneous or @entity4082 induced) and pregnancy. Secondary endpoints were changes in biochemical parameters related to @entity3800 and insulin. RESULTS: Twelve @entity1 completed the @entity2449 arm and 14 the placebo arm. Spontaneous menstruation resumed in five @entity2449 treated @entity1 and in six placebo treated @entity1 , P=0.63. No @entity1 given @entity2449 spontaneously ovulated, although one @entity1 given placebo did, P=0.30. There was no difference in the efficacy of @entity4082 between the two groups with ovulation being induced in five (out of 12) @entity2449 treated @entity1 and four (out of 14) placebo treated @entity1 , P=0.63. Pregnancy occurred in three (out of 12) @entity1 given @entity2449 and two (out of 14) @entity1 given placebo, P=0.59. CONCLUSIONS: @entity2449 is not always beneficial when given to @entity4082 resistant infertile @entity1 with @entity3610 in clinical practice.

title: @entity2449 does not enhance ovulation induction in XXXX resistant @entity3610 in clinical practice.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome', 'PCOS']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene']

entities_list: @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']

entities_list: @entity2449 :: ('MESH:D008687', 'Chemical') :: ['Metformin', 'metformin']

answer: @entity4082 :: (MESH:D002996,Chemical) :: ['clomiphene']


abstract: @entity591 , in particular @entity956 after surgery for @entity299 , is associated with a high mortality. Treatment with various antiarrhythmic drugs and/or antitachycardia pacemakers is not very successful. @entity2778 , a Class III drug, has shown to be a promising drug in adults with @entity591 . However, the experience with @entity2778 in @entity1 after surgery for @entity299 is limited. Therefore, we describe our results here. Between December 1990 and February 1997, 26 @entity1 with @entity591 , most of them with @entity955 (n = 20), after surgery for @entity299 were treated with @entity2778 orally. The age of the @entity1 at the start of treatment was 7.5 +/- 5.8 years (mean +/- SD). The time interval between surgery and the start of @entity591 ranged from 1 day to 14.3 years (3.8 +/- 3.8 years). Conversion to sinus rhythm was achieved in 16 out of 22 hemodynamically stable @entity1 with a dosage of 4.0 +/- 1.6 mg/kg per day. The six @entity1 without sinus rhythm on @entity2778 and four hemodynamically unstable @entity1 were treated prophylactically with @entity2778 after DC cardioversion for their @entity591 . Two @entity1 complained of mild transient @entity1295 . Heart rate decreased during therapy (95 +/- 33 vs 81 +/- 21 beats/min; P = 0.01). QTc-intervals did not change. Proarrhythmias such as @entity1166 were not encountered. Two @entity1 with a preexistent sick @entity1817 showed aggravation of @entity1168 and needed pacemaker implantation. The percentage of @entity1 with a recurrence-free interval of 1 and 2 years was 96% and 81%, respectively, for all @entity591 , and 92% and 66% for @entity956 . The recurrences of @entity591 during the follow-up period, which ranged from 0.1-6.1 years (2.5 +/- 1.8 years) could be treated with only an increase of the dosage of @entity2778 in all but one @entity1 . We conclude that @entity2778 is an effective drug for the treatment and prevention of @entity591 in @entity1 after surgery for @entity299 .

title: @entity2778 for XXXX after surgery for @entity299 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1166 :: ('MESH:D016171', 'Disease') :: ['torsades de pointes']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['atrial tachycardias', 'atrial tachycardia', 'tachycardias', 'Atrial tachycardias']

entities_list: @entity1817 :: ('MESH:D012804', 'Disease') :: ['sinus syndrome']

entities_list: @entity2778 :: ('MESH:D013015', 'Chemical') :: ['Sotalol', 'sotalol']

entities_list: @entity956 :: ('MESH:D001282', 'Disease') :: ['atrial flutter']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial flutter or fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

answer: @entity591 :: (MESH:D013610,Disease) :: ['atrial tachycardias']


abstract: In the freshwater cnidarian polyp @entity54849 , cell death takes place in multiple contexts. Indeed apoptosis occurs during oogenesis and spermatogenesis, during starvation, and in early head regenerating @entity3455 , promoting local compensatory proliferation at the boundary between heterografts. Apoptosis can also be induced upon exposure to pro-apoptotic agents ( @entity3812 , @entity2307 ), upon @entity1457 in the thermosensitive sf-1 mutant, and upon wounding. In all these contexts, the cells that undergo cell death belong predominantly to the interstitial cell lineage, whereas the epithelial cells, which are rather resistant to pro-apoptotic signals, engulf the apoptotic bodies. Beside this clear difference between the interstitial and the epithelial cell lineages, the different interstitial cell derivatives also show noticeable variations in their respective apoptotic sensitivity, with the precursor cells appearing as the most sensitive to pro-apoptotic signals. The apoptotic machinery has been well conserved across evolution. However, its specific role and regulation in each context are not known yet. Tools that help characterize apoptotic activity in @entity54849 have recently been developed. Among them, the aposensor Apoliner initially designed in @entity238 reliably measures @entity2307 -induced apoptotic activity in a biochemical assay. Also, flow cytometry and TUNEL analyses help identify distinctive features between @entity2307 -induced and @entity1457 induced apoptosis in the sf-1 strain. Thanks to the live imaging tools already available, @entity54849 now offers a model system with which the functions of the apoptotic machinery to maintain long-term homeostasis, stem cell renewal, germ cell production, active developmental processes and non-self response can be deciphered.

title: XXXX , a versatile model to study the homeostatic and developmental functions of cell death.

entities_list: @entity2307 :: ('MESH:C009687', 'Chemical') :: ['wortmannin']

entities_list: @entity3812 :: ('MESH:D003078', 'Chemical') :: ['colchicine']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity54849 :: (33058(Tax:7227),Gene) :: ['Hydra']


abstract: @entity1909 is a skin @entity56 response caused by larval stages (cercariae) of the @entity2439 family Schistosomatidae. In the Czech Republic the main causative agents of the disease are bird schistosomes of the genus Trichobilharzia. In the past it was supposed that cercariae of animal schistosomes die soon after the penetration into the @entity1 skin. However, we observed a migration and partial development of T. szidati cercariae within a nonspecific ( @entity19 ) host. The initial development of @entity4801 in @entity19 was similar to that observed in a specific host ( @entity4186 ) as well as to that described in @entity1 schistosomes causing @entity2040 . After penetration, the transformation of T. szidati cercaria to schistosomulum is characterised by ultrastructural and biochemical changes, resulting in formation of a new parasite surface as well as in differences in specific binding of various lectins and host immunoglobulins to parasite surface components. It seems that the transformation of @entity4801 represents a part of their immune evasion within the infected host. It was observed that T. szidati cercariae possess lectins localized on the parasite surface and in postacetabular penetration glands. It is supposed that, after the penetration into the skin, when glycocalyx disappears and gland material is expelled, the parasite surface may serve as an activator of the alternative complement pathway. The postacetabular gland components have probably a lytic function and facilitate migration of @entity4801 through the skin. Moreover, the gland content is considered to play a role in shedding of surface antigens and in changes of parasite tegumental architecture.

title: [Significance of schistosome lectins in the XXXX evoked by penetration of cercaria].

entities_list: @entity2439 :: ('MESH:D014201', 'Disease') :: ['trematode']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']

entities_list: @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasites']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['Cercarial dermatitis']

answer: @entity56 :: (MESH:D004342,Disease) :: ['host allergic reaction']


abstract: Immunohistochemical methods were utilized to systematically map the distribution of @entity3317 -releasing-factor-like immunoreactivity (CRF- @entity3162 ) in the diencephalon, mesencephalon, and rhombencephalon of two monkey species ( @entity11420 and @entity5434 ). A primary antiserum directed against the @entity1 form of the peptide was utilized. Immunoreactive neuronal perikarya and processes were evident in numerous areas, and the distributions of these elements were similar for the two species. As previously reported for @entity35 , monkeys, and @entity1 , intense immunoreactivity was evident in putative hypophyseal neurons in the parvicellular component of the paraventricular nucleus of the hypothalamus and in fibers extending from this area into the median eminence. The results for other brainstem regions, most of which have been previously examined for CRF- @entity3162 only in @entity35 , indicate that many similarities exist between @entity35 and monkeys in the distribution of this peptide in @entity528 , although substantial differences are also evident. For example, immunoreactive perikarya previously observed in other hypothalamic nuclei in @entity35 were not evident in monkeys. Conversely, in monkeys, unlike @entity35 , labeled perikarya were evident in several thalamic nuclei, especially in the intralaminar complex. Also, two large groups of immunoreactive neurons which have generally not been observed in @entity35 studies were present in the mesencephalon and rhombencephalon. In the mesencephalon this consisted of a group of neurons just lateral to the mesencephalic tegmentum, extending throughout the rostral-caudal extent of the midbrain. In the rhombencephalon, labeled perikarya were observed throughout the inferior olive. Some of the differences between @entity35 and monkeys in the locations of labeled perikarya may be due to differences in antiserum specificity and/or sensitivity, or they may result from the fact that @entity3812 pretreatment was not utilized in the present study. The distributions of immunoreactive fibers also exhibited similarities and differences between monkeys and @entity35 . The most striking terminal fields observed in the present study which have not been previously described are a moderate-to-dense field within and adjacent to presumed @entity935 -containing neurons in the substantia nigra pars compacta, a dense innervation of certain subdivisions of the interpeduncular nucleus, and a regionally and parasagittally organized distribution of fibers in the Purkinje cell and molecular layers of the cerebellar cortex.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Distribution of @entity3317 -releasing-factor-like immunoreactivity in brainstem of two monkey species ( @entity11420 and XXXX ): an immunohistochemical study.

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity5434 :: ('9541', 'Species') :: ['Macaca fascicularis']

entities_list: @entity3317 :: ('MESH:D000324', 'Chemical') :: ['corticotropin']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['brainstem extrahypophyseal neuronal circuits']

entities_list: @entity11420 :: ('9521', 'Species') :: ['Saimiri sciureus']

answer: @entity5434 :: (9541,Species) :: ['Macaca fascicularis']


abstract: BACKGROUND: Lepidoglyphus destructor is a common dust mite causing IgE-mediated sensitization. The major allergen, @entity1243 d 2, has previously been cloned and expressed as several double @entity2569 to Ser mutants with the purpose of producing hypoallergenic variants for immunotherapy. Our aim was to investigate the reactivity pattern of IgG1, IgG4 and IgE antibodies to wild-type (wt) rLep d 2 and four mutants among atopic and nonatopic subjects in relation to sensitization and exposure to L. destructor. METHODS: Inhibition and sandwich ELISA were used to compare IgG1, IgG4 and IgE antibody reactivities to rLep d 2 variants in serum of 20 atopic and 18 nonatopic farmers naturally exposed to L. destructor. A group of 22 urban subjects served as controls. RESULTS: @entity8049 correlating IgE and IgG4 levels to rLep d 2(wt) (rs = 0.70; p < 0.0001) which were significantly (p < 0.0001) higher than those of nonatopic farmers and urban controls. No IgG4 antibodies were detected in nonatopic farmers despite chronic allergen exposure. A parallel reactivity pattern of IgE and IgG4 to all rLep d 2 mutants was observed. The mutant lacking all 3 @entity1520 bonds, rLep d 2.6 @entity2569 , demonstrated neither any IgE nor IgG4 reactivity. In contrast, IgG1 antibodies had a different reactivity pattern and were detected among most subjects irrespective of atopy, exposure to L. destructor or @entity1520 impairments in rLep d 2. Moreover, IgG1 levels to rLep d 2(wt) and rLep d 2.6Cys correlated (n = 60; rs = 0.65; p < 0.0001). CONCLUSIONS: IgE/IgG4 Ab to rLep d 2 were restricted to @entity8049 parallel recognition patterns of conformational epitopes. In contrast, IgG1 antibodies are ubiquitously found and mainly recognize sequential structures. The observed isotypic difference and interindividual variation in antibody specificities among atopic and nonatopic subjects imply careful investigation of hypoallergenic variants destined for immunotherapy.

title: IgG1, IgG4 and IgE antibody reactivity to mutant forms of the major dust mite allergen XXXX d 2 among atopic and nonatopic subjects naturally exposed to Lepidoglyphus destructor.

entities_list: @entity8049 :: ('MESH:C564156', 'Disease') :: ['Atopic farmers demonstrated', 'atopic farmers and demonstrated']

entities_list: @entity1520 :: ('CHEBI:48343', 'Chemical') :: ['disulfide']

answer: @entity1243 :: (3952,Gene) :: ['Lep']


abstract: PURPOSE: The developing generic market has huge advantages of availability and affordability of therapy. The question of whether a therapeutic equivalent substitute under an unfamiliar name may cause @entity911 that leads to medical errors has not been sufficiently studied. This paper seeks to answer this question. DESIGN/METHODOLOGY/APPROACH: The study was triggered following sporadic reports according to which @entity1 mistakenly consider therapeutic equivalents as unrelated medications rather than substitutes. Family physicians and pharmacists in one of eight districts of Clalit, Israel's largest healthcare provider were surveyed. The survey's questions recall episodes of medication uncertainty, @entity911 , misidentification, and medication mistakes associated with switching from one therapeutic equivalent to another. A total of 66 physicians and 63 pharmacists responded to the surveys (61 percent and 45 percent, respectively). FINDINGS: The results recall uncertainty, @entity911 , misidentification, and mainly cases of medication mistakes in which @entity1 consumed both therapeutic equivalents simultaneously as was reported by 81 percent of physicians and 70 percent of pharmacists. RESEARCH LIMITATIONS/IMPLICATIONS: There are two limitations in this work, the first is the study type, which is recall survey; the second is the response rate which is not unusual among health care professionals. However, the high face-validity and the consistency of the findings in both physicians and pharmacists surveyed indicates high validity of the study conclusions. PRACTICAL IMPLICATIONS: A practical implication is unique medication error of consuming both therapeutic equivalents simultaneously. The authors wish to raise awareness of the potential of such error, which may be difficult to disclose as each of the therapeutic equivalents is apparently the intended medication but consuming them simultaneously results practically in doubling the intended dose. Given the forecast for generic market growth, awareness is not enough and worldwide regulatory cooperation should be made otherwise these types of medication errors will inevitably emerge. ORIGINALITY/VALUE: The study is original as a literature search revealed no studies evaluating potential medication mistakes attributed to a switch between therapeutic equivalents.

title: Therapeutic equivalent substitute that is new or unfamiliar to the chronic XXXX may result in medication error.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: PURPOSE: To describe the clinical features of the syndrome of neurologically isolated episodic unilateral @entity5564 . METHODS: Information was obtained by reviewing the case records of 24 @entity1 evaluated by the author and collected by polling other neuro-ophthalmologists. RESULTS: Nineteen @entity1 were @entity1 . The median age was 31 years. Fourteen @entity1 had @entity2704 . The median interval between onset of events and evaluation was 6 months. The median duration and frequency of events were 12 hours and two to three per month, respectively. Most @entity1 did not identify any factor that could precipitate an occurrence. The most common associated symptoms during an episode included @entity227 in 15 @entity1 , @entity10 in 9, and @entity158 in 5. Eleven @entity1 were examined during an attack. Three @entity1 who were examined had @entity227 , four had impaired accommodative function, and six had an anisocoria that increased with added ambient light. None of these @entity1 had a @entity36898 or cholinergic agonist-induced pharmacologic @entity5564 . Five other @entity1 examined during an attack had normal vision and unimpaired direct light reactivity of their large pupil. No @entity16 was identified after neurodiagnostic testing, clinical evaluation, and natural history observation. CONCLUSIONS: The syndrome of @entity5564 probably comprises a heterogeneous group of conditions that result in @entity1539 sphincter in some @entity1 , and sympathetic hyperactivity of the iris dilator in others. @entity1 with episodes similar in characteristics to the ones described in this survey appear to have a benign neurologic prognosis, and do not require further neurodiagnostic studies.

title: XXXX . Clinical characteristics.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['impaired near vision', 'visual blur']

entities_list: @entity36898 :: ('MESH:D015845', 'Disease') :: ['tonic pupil']

entities_list: @entity1539 :: ('MESH:D007499', 'Disease') :: ['parasympathetic insufficiency of the iris']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disorder']

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraines']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['orbital pain']

entities_list: @entity5564 :: ('MESH:D015878', 'Disease') :: ['mydriasis', 'idiopathic episodic unilateral mydriasis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity5564 :: (MESH:D015878,Disease) :: ['Benign episodic unilateral mydriasis']


abstract: Single high dose-large field irradiation (SHD-LFI) has been used for palliation of symptoms secondary to widely disseminated @entity5 . Fifty @entity1 with various @entity5 were treated with this technique in a private free-standing radiation therapy center between May 1982 and December 1984. Sixty-four treatments were delivered to the 50 @entity1 . Thirty-two treatments were delivered to upper half-body fields, 15 to midbody, and 17 to thoracic fields. The most frequently used dose was 6 Gy which was used for 55 treatments. Thirty-nine @entity1 had favorable response to treatment. All 22 @entity1 with performance status (PS) 1-2 improved following treatment and 17 of 28 PS 3-4 improved. Only mild hematologic and gastrointestinal @entity137 was seen. One case of possible radiation @entity55 developed. It is concluded that SHD-LFI is a valuable palliative technique for general clinical use.

title: Single high dose-large field irradiation for palliation of advanced XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'malignancies']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancies']


abstract: We present a case of @entity1824 ( @entity1824 ) in the abdominal cavity at the falciform ligament. A 30-yr-old Korean @entity1 visited to hospital for the evaluation of a growing, palpable abdominal mass. He had felt the mass growing over 6 months. There was no family or personal history of @entity2916 . The resected specimen showed a mass of 8.0x7.0x5.5 cm in size. Histological examination showed sheets of spindle-to-epithelioid cells with clear-to-eosinophilic cytoplasm. Immunohistochemically, @entity5 cells were positive for HMB-4 ( @entity9857 ) and smooth muscle actin. They were also positive for the @entity2281 , which is a marker of @entity5 . @entity1 was treated with radical resection of @entity5 without any adjuvant therapy. He is well and on follow-up visits without @entity5 recurrence.

title: @entity1824 ( XXXX ) of abdominal cavity from falciform ligament: a case report.

entities_list: @entity1824 :: ('MESH:D054973', 'Disease') :: ['PEComas', 'perivascular epithelioid cell tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neurogenic and melanocytic tumors']

entities_list: @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis']

answer: @entity1824 :: (MESH:D054973,Disease) :: ['PEComa']


abstract: Currently, @entity353 are frequently used as surgical treatments for medial orbital wall fractures. However, these 2 surgical techniques have not been comprehensively compared using objective criteria. Therefore, the results of these 2 techniques were compared retrospectively using 8 objective criteria in @entity1 with medial orbital wall @entity174 . This study included 48 medial orbital wall @entity174 @entity1 treated from June 1993 to July 2006: 29 had @entity52878 had transcaruncular reduction. Computed tomographic scans, @entity892 field testing for @entity892 using Goldmann perimetry, and Hertel exophthalmometer (Richmond Products, Albuquerque, NM) were done pre- and postsurgery. The average follow-up period was 70.8 months. Among @entity1 with pure medial orbital wall fractures, the average reduction rate was 89.2% for the endoscopic endonasal reduction group and 90.7% for the transcaruncular reduction group. One case in the endoscopic endonasal reduction group had a more than 2-mm enophthalmos after surgery. The @entity892 correction rate was 1.8% in the endoscopic endonasal reduction group and 2.7% in the transcaruncular reduction group. None of the above differences was statistically significant. However, among @entity1 with pure medial orbital wall fractures compared with the transcaruncular reduction group, the average operation time, the average hospital stay, and the average cost were significantly greater in the endoscopic endonasal reduction group. The 2 surgical methods had a similar effectiveness; however, transcaruncular reduction seemed to be more advantageous with respect to the operation time, the length of hospital stay, and cost.

title: XXXX for the treatment of medial orbital wall fractures.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['endoscopic endonasal reduction and transcaruncular reduction']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['double vision', 'diplopia']

entities_list: @entity52878 :: ('MESH:C567026', 'Disease') :: ['endoscopic endonasal reduction and 19']

answer: @entity353 :: (MESH:D015431,Disease) :: ['Comparison of endoscopic endonasal reduction and transcaruncular reduction']


abstract: This paper analyzes 737 cases of curative resection for @entity189 treated from January 1958 to December 1987. Males 407 and females 330. The ages ranged from 17-84. The follow up period was 1 to 30 years. 217 @entity1 developed recurrence or @entity3 and the disease-free survival was 3 months to 15.5 years with a median of 24.2 months. Most of the recurrence occurred in 2 years and was found in the pelvis after abdominoperineal resection and the site of @entity254 after anterior resection. The chief metastatic sites were: lung, liver and inguinal nodes in order of frequency. Factors influencing recurrence and @entity3 were: site of @entity5 , Dukes stage, pathologic type, differentiation of @entity5 , node involvement, and method of operation. Adjuvant irradiation could reduce local recurrence. @entity1 prone to developing recurrence should be closely followed and the resectable lesions be resected whenever possible.

title: [Factors influencing recurrence and XXXX after curative resection for @entity189 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['rectal carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: @entity2072 potently inhibits @entity750 ( @entity750 ) reuptake in cell bodies and at nerve terminals and @entity750 has been implicated as a modulator of dopaminergic neurotransmission. Chronic use of @entity2072 may lead to a " @entity750 -deficit" form of @entity750 dysregulation. We have examined the status of the @entity750 transporter ( @entity16068 ) using ligand binding and autoradiographic methods in subgroups of @entity2072 @entity1445 deaths. Quantitative autoradiography of [125I] @entity56958 was used to map and measure the effect of chronic @entity2072 use on @entity16068 densities in the striatum, substantia nigra, amygdala, and adjacent paralimbic cortical areas of @entity2072 @entity1445 (CO) victims with and without preterminal evidence of @entity933 ( @entity933 ). @entity16068 densities were elevated in the nucleus accumbens and throughout the anterior and posterior sectors of striatum in CO victims compared with age-matched and drug-free control subjects. In contrast, @entity16068 densities were increased significantly in the anterior striatum, but not the posterior sectors in @entity933 victims. Significant elevations in @entity16068 were measured in the orbitofrontal gyrus (Brodmann area 11), the anterior portion of the insular cortex and the cingulate gyrus (Brodmann area 24) in CO and @entity933 victims. Saturation binding site analysis demonstrated an increase in the density of @entity56958 binding sites with no change in the affinity of the radioligand for the @entity16068 . Chronic @entity2072 exposure upregulated @entity16068 densities in the substantia nigra of the CO, but not @entity933 victims. The lack of @entity16068 upregulation in the substania nigra and posterior striatum suggests the possibility of a distinct phenotype for fatal @entity933 victims that exhibited an acute onset of bizarre and violent behavior prior to @entity204 . Adaptive changes in the @entity16068 densities may contribute to depressed mood and drug craving associated with acute @entity2072 abstinence.

title: XXXX transporters upregulate with chronic @entity2072 use.

entities_list: @entity2072 :: ('MESH:D003042', 'Chemical') :: ['Cocaine', 'cocaine']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['ED', 'excited delirium']

answer: @entity750 :: (MESH:D012701,Chemical) :: ['Serotonin']


abstract: BACKGROUND: The discovery of practical biomarkers is important to realize personalized medicine for @entity1 with @entity5 , including @entity14 ( @entity14 ). PURPOSE: The aim of this study was to determine reliable prognostic biomarkers by the analysis of @entity1 with resectable @entity14 ( @entity14 ). METHODS: Genomic DNA was obtained from the @entity14 tissues of a cohort of 126 @entity1 with @entity14 with curative hepatic resection. The @entity984 / @entity817 mutation spectrum and @entity124 ( @entity124 ) status were successfully analyzed in 100 of the 126 @entity14 tissues and these findings were examined in relation to the @entity1 ' clinical outcomes. RESULTS: The cohort of 100 @entity14 @entity1 consisted of 46 with synchronous and 54 with metachronous liver metastasis. Overall survival and disease-free survival at 5 years were 57.4 and 24.9 %, respectively. @entity124 analysis revealed that none of the 100 @entity14 specimens showed any evidence of @entity124 . By @entity984 / @entity817 mutation analysis, the analyzed @entity14 @entity1 were divided into 3 groups; @entity984 -mutant ( @entity984 -Mt; n = 27), @entity817 -mutant ( @entity817 -Mt; n = 3), and wild-types of both genes (Wild-type; n = 70). In the survival analysis, both @entity984 -Mt and @entity817 -Mt @entity1 showed significantly poorer prognoses compared with Wild-type @entity1 . Furthermore, although the population with the @entity817 mutation was small, this mutation had a significant negative impact on disease-free survival. CONCLUSIONS: In this study, all @entity5 in the cohort of @entity14 @entity1 were @entity5 , suggesting @entity5 in primary @entity14 would rarely reveal metastatic potential. @entity984 and @entity817 mutations are suggested to be poor prognostic factors in @entity14 . Genetic information has an essential role as a prognostic marker and could contribute to the decisions on treatment strategy for @entity14 .

title: Poor prognosis of @entity984 or @entity817 mutant colorectal liver metastasis without XXXX .

entities_list: @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'malignant neoplasias', 'non-MSI tumors', 'MSI cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRLM', 'colorectal liver metastases', 'CRC', 'colorectal cancer']

answer: @entity124 :: (MESH:D053842,Disease) :: ['microsatellite instability']


abstract: Standardized assessment of islet quality is imperative for clinical islet transplantation. We have previously shown that the increment in @entity26 consumption rate stimulated by @entity413 (DeltaOCR(glc)) can predict in vivo efficacy of islet transplantation in @entity19 . To further evaluate the approach, we studied three factors: islet specificity, islet composition and agreement between results obtained by different groups. Equivalent perifusion systems were set up at the City of Hope and the University of Washington and the values of DeltaOCR(glc) obtained at both institutions were compared. Islet specificity was determined by comparing DeltaOCR(glc) in islet and nonislet tissue. The DeltaOCR(glc) ranged from 0.01 to 0.19 nmol/min/100 islets (n = 14), a wide range in islet quality, but the values obtained by the two centers were similar. The contribution from nonislet impurities was negligible (DeltaOCR(glc) was 0.12 nmol/min/100 islets vs. 0.007 nmol/min/100 nonislet clusters). The DeltaOCR(glc) was statistically independent of percent beta cells, demonstrating that DeltaOCR(glc) is governed more by islet quality than by islet composition. The DeltaOCR(glc), but not the absolute level of OCR, was predictive of reversal of @entity4854 in @entity6 @entity19 . These demonstrations lay the foundation for testing DeltaOCR(glc) as a measurement of islet quality for @entity1 islet transplantation.

title: @entity413 -stimulated increment in @entity26 consumption rate as a standardized test of XXXX islet quality.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: We carried out a prospective longitudinal study of 41 @entity1 diagnosed as probably having a mild form of @entity195 according to the data of an investigation of prevalence done in 1991 in the municipality of Habana Vieja. MATERIAL AND METHODS: The research covered two phases, with an interval of one year between them. During both phases the @entity1 were interviewed by the same neurology resident in a door-to-door survey using the Mini-Mental State, Hughes scale ( @entity7958 ) and Blessed scale, to evaluate higher mental functions. We determined the progress of the disease over the course of two years (1991-1992 and 1992-1993) and the frequency and degree of @entity73 during a period of one year. RESULTS AND CONCLUSIONS: There was evidence of progressive worsening of the illness in 46.4% of the @entity1 . In 34.2% this was to a moderate form and in 12.2% to a severe form. There was no progression in 46.3%. In this group 17.0% continued with a diagnosis of doubtful @entity303 and 29.3% as having slight @entity303 . The other 7.3% of the total number of @entity1 (n = 41) were reclassified as normal. Cognitive functions almost always showed a tendency to deteriorate over time, but in a small percentage of @entity1 they did not deteriorate and some even improved. The cognitive functions which deteriorated most were those of orientation, language and copying, with an average deterioration of 28% and 24% respectively with regard to their initial values.

title: [A longitudinal study of the course of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['deterioration of cognitive functions']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer type dementia']


abstract: BACKGROUND: The @entity4236 is a rare @entity5 of neuroectodermal origin, which arises usually in the area of the olfactory epithelium and invades the paranasal sinuses, the orbit and the brain. The low incidence of this disease makes a development of standardised clinical and histological classification difficult. Up to now this @entity5 is considered to be slow progressive but strained by a high rate of local recurrences. @entity3 are usually seen late at an advanced stage. @entity1 : In the last 18 years 7 @entity1 with an @entity4236 were treated in our department. This relatively large number of @entity1 allows a retrospective evaluation of the different already existing classifications concerning treatment and prognosis. RESULTS AND CONCLUSIONS: In all cases of a disease limited on the paranasal sinuses the @entity1 were successfully treated either by a combination of resection and radiation (4 cases) or resection alone (1 case). No @entity1 underwent a chemotherapy. Two cases with lethal outcome showed an extremely aggressive @entity5 progression. In such cases of extensive disease an additional chemotherapy has always to be taken into account. Our experiences and the analysis of the literature gives some indications that middle-aged @entity1 have a worse prognosis than young or old @entity1 .

title: [Classification and prognosis of XXXX based on 7 treated cases].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity4236 :: ('MESH:D018304', 'Disease') :: ['esthesioneuroblastoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastasis']

answer: @entity4236 :: (MESH:D018304,Disease) :: ['esthesioneuroblastoma']


abstract: BACKGROUND: Primary @entity254 with or without proximal diversion is increasingly applied to @entity1 requiring urgent colectomy for complicated disease of the left colon. As such, the Hartmann procedure is now often restricted to @entity1 who are unstable or otherwise poor candidates for primary @entity254 . We sought to define the complication rate of Hartmann takedown in a contemporary setting. METHODS: Consecutive adult @entity1 undergoing colostomy takedown with colorectal @entity254 at an @entity4207 teaching hospital from January 1, 2001, to December 31, 2010, were included in the study. Complications were captured prospectively by a single trained nurse practitioner. Demographics, body mass index, American Society of Anesthesiologists (ASA) classification, interval between Hartmann procedure and subsequent takedown, surgical indication, duration of surgery, surgeon volume and specialty, length of stay, and complications were recorded. RESULTS: One hundred three @entity1 underwent Hartmann reversal by 16 different surgeons; 7 of these surgeons performed 4 or fewer procedures during the study period. During the same time period, 334 @entity1 underwent a Hartmann procedure at our institution. Seventy-seven of 104 @entity1 (74%) had their index resection for complicated @entity4436 ; an @entity834 was the second most common indication. The median age was 61 years (range 31 to 84 years), and the interval from Hartmann procedure to reversal ranged from 87 to 1,489 days. Only 8 @entity1 (7.7%) had an ASA of 1. Thirty @entity1 (29.1%) had @entity260 , and 12 (11%) had 2 or more complications. There were 2 deaths and 4 @entity834 , and 7 @entity1 had inadvertent enterotomies. Only ASA status predicted @entity260 (P = .01). CONCLUSIONS: Hartmann takedown is a morbid operation with a substantial risk of inadvertent enterotomy and serious complications. Excluding cases referred from elsewhere, there were more than 5-fold the number of Hartmann procedures than takedowns performed during the study period. This suggests that Hartmann procedures are typically restricted to @entity1 who are also poor candidates for takedown and that their colostomy is likely to be permanent.

title: Complications of Hartmann takedown in a decade of preferred primary XXXX .

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak', 'anastomotic leaks']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity4436 :: ('MESH:D004238', 'Disease') :: ['diverticulitis']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: BACKGROUND AND PURPOSE: Few studies have addressed factors that contribute to functional recovery in @entity1 with @entity64 . We assessed the value of using pre-training functional level and cognitive abilities measured at admission in order to predict functional gain in a sample of @entity64 @entity1 . METHODS: The @entity177 ( @entity177 ) was administered to 85 @entity64 @entity1 . Three multiple regression models were constructed using total gain in @entity177 scores, gain in scores in the cognitive domain of @entity177 , and gain in scores in the motor domain of @entity177 as outcome variables. Predictor variables were age; scores on the Digit Span Forward Test (DSF), Digit Span Backward Test (DSB), and Chinese Auditory Verbal Learning Test (CAVLT); and the @entity177 scores measured at admission. RESULTS: All regression models were significant, Ps < 0.001, and each explained over 73% of the variance in the @entity177 gains. Age and admission @entity177 scores were both significant predictors in each of the three models. The DSB span score was a significant predictor of the total @entity177 and the cognitive @entity177 gains. The CAVLT recognition score was also a significant predictor of the cognitive @entity1017 . CONCLUSIONS: Functional improvement in @entity1 with @entity64 after in- @entity1 rehabilitation was predicted by age, pre-training functional level, and cognitive abilities measured at admission.

title: Functional gain in XXXX @entity1 is predicted by functional level and cognitive abilities measured at hospital admission.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['FIM', 'Functional Independence Measure']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'hemorrhagic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['hemorrhagic stroke']


abstract: Consler et al. [Consler, T. G., Persson, B. L., et al. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 6934-6938] described a one-step purification of @entity1132 permease, a hydrophobic membrane transport protein, from @entity526 . Permease constructs containing a @entity1885 acceptor domain are biotinylated in vivo, followed by solubilization and avidin affinity purification. Although a high degree of purity is obtained, only about 15-20% of the permease is recovered due to incomplete biotinylation. In this communication, a simple modification is described that allows quantitative recovery of highly purified permease. Membranes containing permease with the @entity1885 acceptor domain from the @entity3274 @entity5911 decarboxylase are extracted with 5 M @entity1133 or treated with @entity12475 to inactivate F1/Fo ATPase and biotinylated in vitro with @entity1885 ligase, @entity855 and @entity20651 . Subsequently, the membranes are harvested, washed to remove free @entity1885 and solubilized with 2% @entity56315 . Biotinylated permease is then purified in one step by affinity chromatography on monomeric avidin-Sepharose. The purified material is homogeneous and exhibits full activity with respect to ligand binding and counterflow.

title: In vitro biotinylation provides quantitative recovery of highly purified active XXXX permease in a single step.

entities_list: @entity12475 :: ('MESH:D004024', 'Chemical') :: ['dicyclohexylcarbodiimide']

entities_list: @entity3274 :: ('573', 'Species') :: ['Klebsiella pneumoniae']

entities_list: @entity56315 :: ('MESH:C411362', 'Chemical') :: ['n-dodecyl-beta-D-maltopyranoside']

entities_list: @entity5911 :: ('MESH:D062907', 'Chemical') :: ['oxaloacetate']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity1132 :: (MESH:D007785,Chemical) :: ['lactose']


abstract: PURPOSE: The present study presents the experience at the University of Florida with treatment of @entity1 with @entity957 ( @entity957 ) metastatic to cervical lymph nodes from an unknown head-and-neck mucosal (H_NM) site with radiotherapy (RT) alone or in combination with @entity135 ( @entity135 ). METHODS AND MATERIALS: The study included 126 @entity1 treated with curative intent from 1964 to 1997. All @entity1 had follow-up for at least 2 years. No @entity1 were lost to follow-up. RESULTS: Twelve @entity1 (10%) developed @entity957 in H_NM sites at 0.5 to 10.9 years (median, 1.8 years). The rate of developing @entity189 in H_NM sites at 5 years was 13%. Histologic differentiation significantly affected the rate of developing @entity189 in H_NM sites in multivariate analysis. Sixteen @entity1 (13%) had persistent @entity66 and 12 @entity1 (10%) developed recurrent @entity66 at 0.5 to 10.9 years (median, 1.1 years). The nodal control rate at 5 years was 78%. Nodal size, N stage, and planned @entity135 significantly affected the rate of nodal control in multivariate analysis. Nineteen @entity1 (15%) developed distant metastasis at 0.2-5.1 years (median, 0.9 years). The distant metastases rate at 5 years was 14%. Extracapsular extension and RT dose significantly affected the risk of distant metastases in multivariate analysis. The overall absolute survival rate at 5 years was 47%. Extracapsular extension, N stage, RT dose for H_NM sites, and planned @entity135 significantly affected absolute survival in multivariate analysis. The rate of cause-specific survival at 5 years was 67%. Extracapsular extension, nodal size, N stage, overall treatment time, and planned @entity135 significantly affected cause-specific survival in multivariate analysis. Eight @entity1 (6%) had severe @entity260 and 6 @entity1 (5%) had severe late complications. CONCLUSION: The present study supports the effectiveness of RT in lowering the rate of developing @entity189 in the H_NM sites.

title: @entity957 metastatic to cervical lymph nodes from an unknown head-and-neck mucosal site treated with radiation therapy alone or in combination with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['ND', 'neck dissection']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['nodal disease']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['SCC', 'squamous cell carcinomas']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

answer: @entity135 :: (MESH:D006258,Disease) :: ['neck dissection']


abstract: @entity50 ( @entity50 ) is known to be related to a number of underlying aetiologies including @entity2172 , @entity130 , pregnancy, birth control pills, @entity5 , @entity3147 , @entity74 and @entity5 (Fishman, 2000; Raizer and Abbott, 2000). We present the case of a @entity1 with @entity0 receiving the antioestrogen drug @entity440 who developed @entity50 . A 40-year-old female presented as an emergency with a 10-day history of @entity10 and @entity425 . On questioning her past medical history included a diagnosis of @entity0 3 years ago treated by radical mastectomy and @entity440 20 mg daily. At the time of admission, neurologic examination revealed a mild @entity1269 and a present Babinksi sign. Non-contrast enhanced tomography was normal. Magnetic resonance imaging (MRI) showed @entity715 in the superior sagittal sinus, right lateral sinus and jugular vein in addition @entity1188 in the right temporal lobe was present (Figs 1a and b). Routine haematology and biochemistry was normal. Anticoagulation tests, antithrombin III, protein S and C levels were also found to be normal. She was treated with anticoagulation therapy and her @entity1269 improved within 3 days. Control MRI showed the resorption of the @entity1188 and resolution of the @entity715 (Fig. 1c).

title: A case with cerebral thrombosis receiving XXXX treatment.

entities_list: @entity2172 :: ('MESH:D010033', 'Disease') :: ['otitis media']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'malignancy']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['left sided hemiparesis', 'hemiparesis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['left sided weakness']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['venous infarction']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['dehydration, haematologic disorders']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['CST', 'Cerebral sinus thrombosis']

answer: @entity440 :: (MESH:D013629,Chemical) :: ['tamoxifen']


abstract: In a study of 102 consecutive @entity1 hospitalized for previous @entity3328 , we found that 70 @entity1 had continued education after elementary school and 18 were academics. This is a higher proportion than in the general Norwegian population. All 14 @entity1 with @entity1746 had continued education after elementary school, while as many as 12 of 18 @entity1 with a university degree had widespread pareses in the acute phase. Of the @entity1 46 worked or had worked full-time up to 60 years of age. Only 29 @entity1 were receiving a disabled pension. Another 9 @entity1 had neither been employed nor received any pension, all housewives. Nine of 14 @entity1 with @entity1746 were working full-time, only 2 received disabled pension. Among the 35 @entity1 with persisting widespread pareses, 11 were still in full-time work and 7 were working part-time. The employment rate among the @entity1 in this study was nearly identical to the age-correlated general employment rate in Norway. Our conclusion is that polio @entity1 are doing well in society; they have taken education, are working, and are generally self-supported. The degree of pareses does not seem to have been the most determining factor for their educational and professional activity.

title: XXXX : long-time consequences for social life.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3328 :: ('MESH:D011051', 'Disease') :: ['poliomyelitis']

entities_list: @entity1746 :: ('MESH:D020335', 'Disease') :: ['paraparesis']

answer: @entity3328 :: (MESH:D011051,Disease) :: ['Poliomyelitis']


abstract: @entity1120 is the most prevalent @entity2315 and it results from inherited @entity1120 . The glucocerebrosidase gene from normal @entity1 was sequenced by several laboratories and it was noted that a G or A nucleotide may be present at cDNA position 1601, resulting in 495 @entity369 or 495 @entity3793 in the glucocerebrosidase polypeptide. In order to rule out the possibility of cloning error and to elucidate the genetic status of the two genotypes and their distribution in the population, we have developed a convenient and reliable method for the molecular screening of the 1601G and 1601A genotypes in the population. This method uses PCR amplification of glucocerebrosidase genomic DNA in blood samples, followed by BsaHI restriction fragment length polymorphism analysis. Out of the 256 subjects without @entity1120 and 15 Gaucher @entity1 surveyed, the 1601G genotype was present in the homozygous form in all of the asymptomatic subjects and 14 Gaucher @entity1 . In one Gaucher @entity1 who was diagnosed as having type 1 (non-neuropathic) @entity1120 with the @entity40788 / @entity53927 mutations, the heterozygous @entity53928 genotype was detected. These findings indicate that the 1601G genotype which encodes 495arginine of the glucocerebrosidase polypeptide is not a cloning error. Instead, it constitutes the normal as well as predominant genotype in the population in the municipality of Greater Victoria, British Columbia. The 1601A genotype, on the other hand, appears to be quite infrequent in this population. The availability of our restriction enzyme based method has allowed the screening and frequency determination of these two alleles in other populations.

title: XXXX : molecular screening of the glucocerebrosidase 1601G and 1601A alleles in Victoria, British Columbia, Canada.

entities_list: @entity2315 :: ('MESH:D016464', 'Disease') :: ['lysosomal storage disease']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people']

entities_list: @entity3793 :: ('CHEBI:27570', 'Chemical') :: ['histidine']

entities_list: @entity1120 :: ('MESH:D005776', 'Disease') :: ['Gaucher disease', 'deficient glucocerebrosidase activity']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity1120 :: (MESH:D005776,Disease) :: ['Gaucher disease']


abstract: OBJECTIVE: Annual @entity6 has been implemented in England since 2008. This study aimed to estimate changes in the detection of @entity989 in the first 4 years of the program. RESEARCH DESIGN AND METHODS: @entity1 included 32,340 @entity1 with @entity164 2 @entity6 resident in three London boroughs with one or more screening records between 2008 and 2011. Data for 87,570 digital images from 2008 to 2011 were analyzed. Frequency of sight-threatening @entity6 (STDR) was estimated by year of screen for first screens and for subsequent screens according to @entity989 status at first screen. RESULTS: Among 16,621 first-ever screens, the frequency of STDR was 7.1% in 2008, declining to 6.4% in 2011 (P = 0.087). The proportion with a duration of @entity6 of <1 year at first screen increased from 18.7% in 2008 to 48.6% in 2011. Second or later screens were received by 26,308 @entity1 . In @entity1 with @entity989 at first screen, the proportion with STDR at second or later screen declined from 21.6% in 2008 to 8.4% in 2011 (annual change -2.2% [95% CI -3.3 to -1.0], P < 0.001). In @entity1 with no @entity989 at first screen, STDR declined from 9.2% in 2008 to 3.2% in 2011 (annual change -1.8% [-2.0 to -1.7], P < 0.001). Declining trends were similar in sociodemographic subgroups. CONCLUSIONS: After the inception of population-based @entity6 , @entity1 at lower risk of STDR contribute an increasing proportion to the eligible population, and the proportion detected with STDR at second or subsequent screening rounds declines rapidly.

title: Changes in detection of @entity989 in @entity164 2 @entity6 in the first 4 years of a population-based XXXX program: retrospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic eye screening', 'diabetes', 'diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy', 'mild nonproliferative retinopathy']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic eye screening']


abstract: Radioresistant @entity5 cells are found in @entity5 specimens from @entity1 in whom radiotherapy has failed or whose @entity5 have recurred after therapy. This suggests that inherent cellular radioresistance may in part underlie the failure of radiotherapy, and therefore determination of the presence of resistant cells within a @entity5 might be a useful predictor of response to radiation therapy. Most standard clonogenic assays of radiation response are time-consuming, and alternative assays of radiation response are being sought. In an earlier publication (J. L. Schwartz et al., Int. J. Radiat. Oncol. Biol. Phys. 15, 907-912, 1988), we reported that radioresistant @entity1 @entity5 cells rejoin DNA double-strand breaks, as measured by DNA neutral filter elution (pH 9.6), faster than more sensitive cell lines. To determine whether DNA elution might have potential as a rapid predictive assay, we examined the relationship between the rate of DNA double-strand break rejoining and radiosensitivity in nine first-passage-after-explant @entity957 under conditions that minimized the influence of nontumor and nonclonogenic cells. The frequency of DNA double-strand breaks measured 1 h after irradiation with 100 Gy 60Co gamma rays was used as an estimate of relative rejoining rate. This number is a reflection of both the initial DNA double-strand break frequency and the amount of repair that occurs in 1 h. The relative break frequency was compared to radiosensitivity as measured by standard clonogenic survival assays in later passages (p3-p14) of these same cells. A significant relationship (r = 0.61, P less than 0.01) was found between break frequency measured in first-passage cells and radiosensitivity measured in later passages, suggesting that the neutral elution assay as described here has some promise as a relatively rapid assay of the radiosensitivity of @entity1 @entity5 cells.

title: Prediction of the radiation sensitivity of @entity1 XXXX cells using DNA filter elution.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma']


abstract: The effect of oral controlled-release (CR), oral transmucosal (buccal; @entity9321 ) and transdermal (TDD) drug delivery systems on plasma concentrations of @entity2493 (MT) and its principal metabolite in @entity1 subjects using a crossover, single dose design was evaluated. Twelve adult male volunteers participated in the study and received all three dosage forms on three separate occasions. All patch dosage forms were removed after 10 h of wear. Plasma concentrations of the parent drug and its metabolite, @entity12604 (MT6s) were measured by radioimmunoassay. Between-subject plasma concentrations of MT were very variable following both oral CR and TDD. Use of the oral CR system gave plasma MT profiles in some subjects that were initially similar to physiological levels, but then differed substantially from physiological in the rate of MT offset; in a few subjects, plasma MT levels remained consistently much below normal nocturnal physiological levels. Also, the ratio of metabolite to parent drug by the oral CR route was many times greater than physiological. TDD resulted in a significant delay in systemic drug levels and a gradual decline in drug delivery after patch removal, possibly due to deposition of @entity2493 in the skin. TDD failed to simulate the physiological plasma profile of MT (rapid achievement of steady-state blood levels and rapid decline after removal of the patch; i.e., so-called "square-wave" profile). @entity9321 provided prompt systemic drug levels with less variability than oral CR or TDD delivery. Also, plasma MT levels fell promptly and rapidly after removal of the patch. No indication of mucosal deposition was observed. @entity9321 was able to mimic the physiological plasma profiles of both MT and its principal metabolite.

title: Transmucosal, oral controlled-release, and transdermal drug administration in @entity1 subjects: a crossover study with XXXX .

entities_list: @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin']

entities_list: @entity12604 :: ('MESH:C054513', 'Chemical') :: ['6-sulfatoxymelatonin']

answer: @entity2493 :: (MESH:D008550,Chemical) :: ['melatonin']


abstract: We conducted a case-control study of @entity995 , which results from a new germline @entity996 mutation, to investigate the role of parents' diet before their @entity1 's conception. Parents of 206 cases from nine North American institutions and 269 controls participated; of these, fathers of 184 cases and 223 controls and mothers of 204 cases and 260 controls answered a food frequency questionnaire administered by phone about their diet in the year before the @entity1 's conception. Cases provided DNA for @entity996 mutation testing. We assessed parents' diet by examining 19 food groups. Father's intake of dairy products and fruit was associated with decreased risk and cured meats and sweets with increased risk. Mother's intake was not associated with disease for any food group. Considering analyses adjusted for the other food groups significantly associated with disease, @entity7493 , and demographic characteristics as well as more fully adjusted models, the associations with father's dairy products and cured meat intake were the most robust. In the fully adjusted, matched analysis, the odds ratios per daily serving were 0.70 (95% confidence interval (CI) 0.49-1.00, P = 0.047) for dairy products and 5.05 (CI 1.46-17.51, P = 0.01) for cured meat. The pattern of associations with paternal but not maternal diet is consistent with the fact that 85% of new germline @entity996 mutations occur on the father's allele. As few @entity1 data exist on the role of diet in any condition resulting from new germ-cell mutation, additional studies will be needed to replicate or refute our findings.

title: Parental diet and risk of XXXX resulting from new germline @entity996 mutation.

entities_list: @entity7493 :: ('MESH:D011502', 'Disease') :: ['energy intake']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['sporadic bilateral retinoblastoma']

answer: @entity995 :: (MESH:D012175,Disease) :: ['retinoblastoma']


abstract: @entity792 induced an increment in @entity21167 populations in intact @entity19 spleen lymphocytes. Normal and autoimmune lymphocytes incubated with @entity52042 increased the mechanical response of isolated atria. Autoimmune cells were more effective than normal cells in inducing this response. @entity52042 or spleen cells alone did not modify the contractility at the concentration used. Inhibitors of @entity8042 -adrenoceptors of spleen cells completely blunted the reaction between @entity52042 and lymphocytes, while when atria were exposed to @entity24971 , mechanical activity induced by @entity52042 plus lymphocytes was not affected. Cell-free supernatants of lymphocytes exposed to @entity52042 elicited the reaction in the same way as @entity52042 -treated lymphocytes. Direct contact of cells with the assay organ was not necessary. Inhibitors of cyclooxygenase on lymphocytes blocked the reaction of @entity52042 -treated lymphocytes on atria, while inhibitors of lipoxygenase(s) completely blocked the reaction of atria exposed to @entity52042 -stimulated lymphocytes or supernatants. These results suggest that @entity52042 reacts with @entity8042 -adrenoceptors of normal and autoimmune cells. From this reaction, soluble factors are released that in turn trigger stimulation of the atrial contractility as a consequence of the release of oxidative products of the lipoxygenase(s) pathway of @entity1426 from atria. The high activity of atria in the presence of autoimmune spleen cells is probably related to the increment in number of @entity8042 -adrenoceptors of these cells.

title: Role of XXXX -adrenoceptors in the biological effect of @entity792 spleen cells.

entities_list: @entity52042 :: ('MESH:C100252', 'Chemical') :: ['soterenol', 'Soterenol']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity24971 :: ('MESH:D002078', 'Chemical') :: ['butoxamine']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['Autoimmune orchitis']

answer: @entity8042 :: (15130(Tax:10090),Gene) :: ['beta 2']


abstract: The purpose of this study was to perform a randomized, prospective comparison of @entity11013 (CS--100 mg of @entity701 /60 cc P.R. q.h.s.; n = 12), @entity2983 enemas ( @entity3504 --4 g/60 cc P.R. q.h.s.; n = 19), and @entity14559 enemas (SCFA--60 cc P.R. b.i.d.; n = 14) for the treatment of @entity9916 . @entity1 presenting to the Ferguson Clinic with the diagnosis of @entity9916 were evaluated for age, sex, prior history of @entity4272 , duration of symptoms prior to presentation, endoscopic scoring, and mucosal biopsies. Clinical evaluation was performed at two-week intervals for six weeks, with repeat biopsies taken at six weeks. There was no significant difference with respect to age, male/female ratio, past @entity9916 , length of colorectum involved at the time of initial presentation, symptom resolution, and endoscopic and histologic improvement among the three treatment groups. Recovery occurred in a similar proportion in each of the three groups: CS, 10/12; @entity3504 , 17/19; and SCFA, 12/14. The cost of six weeks of treatment was: CS,  71.82; @entity3504 ,  347.28; and SCFA,  31.50. This study indicates that SCFA enemas are equally efficacious to CS or @entity3504 enemas for the treatment of @entity9916 at a significant cost savings.

title: Short-chain fatty acid enemas: a cost-effective alternative in the treatment of nonspecific XXXX .

entities_list: @entity11013 :: ('MESH:C565152', 'Disease') :: ['corticosteroid enemas']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity9916 :: ('MESH:D011350', 'Disease') :: ['idiopathic proctosigmoiditis', 'history of proctosigmoiditis', 'proctosigmoiditis']

entities_list: @entity4272 :: ('MESH:D011349', 'Disease') :: ['proctitis']

entities_list: @entity14559 :: ('CHEBI:26666', 'Chemical') :: ['short-chain fatty acid']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone']

entities_list: @entity2983 :: ('MESH:D019804', 'Chemical') :: ['mesalamine']

answer: @entity9916 :: (MESH:D011350,Disease) :: ['proctosigmoiditis']


abstract: PURPOSE: To determine the prevalence of sleep-related symptoms and sleep-related @entity387 by polysomnography in @entity1 with normal-tension @entity726 (NTG). @entity1 AND METHODS: This comparative case series included 23 @entity1 with NTG, 14 NTG suspects, and 30 comparison @entity1 without NTG. A sleep history was obtained and determined to be positive or negative. Polysomnography was offered for @entity1 with a positive sleep history. Prevalence of a positive sleep history and prevalence of @entity25 were the main outcome measures. RESULTS: The NTG, NTG suspect, and comparison groups did not differ with respect to age, body mass index, @entity262 , gender, or race. Thirteen (57%) of 23 @entity1 with NTG, 6 (43%) of 14 NTG suspects, and 1 (3%) of 30 comparison @entity1 had a positive sleep history (P = 0.001). Nine of 13 @entity1 with NTG and four of six NTG suspects with a positive sleep history chose to undergo polysomnography. Seven (78%) of nine @entity1 with NTG and all four NTG suspects undergoing polysomnography were diagnosed with a @entity25 . Five @entity1 with NTG had sleep @entity386 and two had @entity387 . Two NTG suspects had sleep @entity386 ; one had @entity387 ; and one had upper @entity1224 . The one comparison @entity1 with a positive sleep history had upper @entity1224 by polysomnography. CONCLUSIONS: Sleep-disturbed breathing may be a risk factor for NTG. Although we do not provide evidence for a cause-and-effect relationship, various physiologic factors produced by sleep-disturbed breathing may play a significant role in the pathogenesis of this @entity1781 . We recommend obtaining a sleep history from @entity1 with NTG and performing polysomnography in those @entity1 with @entity25 .

title: @entity25 : a risk factor for normal-tension XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep hypopnea', 'breathing disorders']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance symptoms', 'sleep disorders', 'sleep disorder']

entities_list: @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway resistance syndrome']

answer: @entity726 :: (MESH:D005901,Disease) :: ['glaucoma']


abstract: The peroxisome proliferator-activated receptors (PPARs) -a, -  /b and -y are the ligand-activated transcription factors that function as the master regulators of @entity413 , @entity844 and lipoprotein metabolism, energy balance, cell proliferation and differentiation, @entity32 , and @entity731 . The objective of the current study was to examine the main and interactive effect of seven single nucleotide polymorphisms (SNPs) of @entity5601  /y in contribution to @entity1144 . A total of 820 subjects were randomly selected and no individuals were related. The selected SNPs in @entity5601   ( @entity28713 and @entity28714 ) and @entity6864 ( @entity28715 , @entity28716 , @entity28717 , @entity28718 , and @entity28719 ) were genotyped. Mean difference and 95% confident interval were calculated. Interactions were explored by the method of generalized multifactor dimensionality reduction. After adjustment for gender, age, and smoking status, it was found that the carriers of the C allele (TC  +  CC) of @entity28713 were associated with a decreased risk of @entity1144 compared to the carriers of the TT genotype (mean difference  =  -2.63, 95% CI  =  -3.61--1.64, P  <  0.0001). A significant two-locus model (P  =  0.0107) involving @entity28713 and @entity28715 and a significant three-locus model (P  =  0.0107) involving @entity28713 , @entity28714 , and @entity28716 were observed. Overall, the three-locus model had the highest level of testing accuracy (59.85%) and showed a better cross-validation consistency (9/10) than two-locus model. Therefore, for @entity1144 defined by waist circumference, we chose the three-locus model as the best interaction model. In conclusion, the C allele in @entity28713 was significantly associated with a lower @entity1144 . Moreover, an interaction among @entity28713 , @entity28716 , and @entity28714 on incident @entity1144 could be demonstrated.

title: Gene-gene interaction between @entity5601   and XXXX is associated with @entity1144 in a Chinese population.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1144 :: ('MESH:D056128', 'Disease') :: ['abdominal obesity']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6864 :: (5468,Gene) :: ['PPARy']


abstract: OBJECTIVE: To examine the role of pelvic floor exercises as a way of restoring erectile function in @entity1 with @entity323 . @entity1 AND METHODS: In all, 55 @entity1 aged > 20 years who had experienced @entity323 for > or = 6 months were recruited for a randomized controlled study with a cross-over arm. The @entity1 were treated with either pelvic floor muscle exercises (taught by a physiotherapist) with biofeedback and lifestyle changes (intervention group) or they were advised on lifestyle changes only (control group). Control @entity1 who did not respond after 3 months were treated with the intervention. All @entity1 were given home exercises for a further 3 months. Outcomes were measured using the International Index of Erectile Function (IIEF), anal pressure measurements and independent (blinded) assessments. RESULTS: After 3 months, the erectile function of @entity1 in the intervention group was significantly better than in the control group (P < 0.001). Control @entity1 who were given the intervention also significantly improved 3 months later (P < 0.001). After 6 months, blind assessment showed that 40% of @entity1 had regained normal erectile function, 35.5% improved but 24.5% failed to improve. CONCLUSION: This study suggests that pelvic floor exercises should be considered as a first-line approach for @entity1 seeking long-term resolution of their @entity323 .

title: Pelvic floor exercises for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients', 'men']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction']

answer: @entity323 :: (MESH:D007172,Disease) :: ['erectile dysfunction']


abstract: In 11 @entity1 with stable premature ventricular beats, the kinetics of single (150 and 300 mg) and multiple (150 mg t.i.d. and 300 mg t.i.d.) oral doses of @entity2779 were studied with reference to @entity943 suppression. During the acute phase detectable plasma levels of the drug were achieved only with the higher dose. In 8 out of 10 patients the antiarrhythmic effect was obtained with the 300 mg dose, which was found to predict responsiveness at steady-state. During the chronic phase, antiarrhythmic efficacy was obtained with the lower dose regimen (150 mg t.i.d.) in half of those @entity1 . A wide range of effective plasma levels was observed. The previously suggested therapeutic range (0.5-2.0 micrograms/ml) was not adequate in predicting either antiarrhythmic activity or adverse effects. The results show the role of @entity2779 metabolites in determining total antiarrhythmic action.

title: Antiarrhythmic efficacy of XXXX : evaluation of effective plasma levels following single and multiple doses.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity2779 :: ('MESH:D011405', 'Chemical') :: ['propafenone']

answer: @entity2779 :: (MESH:D011405,Chemical) :: ['propafenone']


abstract: BACKGROUND: The purpose was to study activation markers of the eosinophil granulocytes in @entity2023 , and the impact of topical steroid therapy thereupon. METHODS: Sixty-three @entity2490 @entity1 with monoallergy to grass were examined before and at peak pollen season. Blood eosinophil count, @entity11153 ( @entity11153 ), and @entity29074 ( @entity29074 ) in serum and nasal lavage fluid were measured. During the season, @entity1 were randomized to treatment with intranasal @entity5023 0.1 mg o.d. (n=26), 0.2 mg o.d. (n=25), or placebo (n=12). Six healthy @entity1 served as controls. RESULTS: During the season, all parameters, except nasal lavage @entity11153 , increased in the placebo group (P<0.001-P<0.05). Significant differences were seen between the @entity134 groups and the placebo group for all parameters (P<0.001-P<0.05). Higher eosinophil count (P<0.05), serum @entity29074 (P<0.02), and nasal lavage @entity29074 (P<0.05) were found in @entity1 before season than in controls. The following winter, 44 @entity1 returned for repeated measurement. Lower levels of nasal lavage @entity29074 were observed for @entity1 than levels at the beginning of the season (P<0.0001). CONCLUSIONS: Intranasal @entity5023 reduced @entity32 of the nasal mucosa, demonstrated locally by nasal lavage @entity11153 and @entity29074 , and systemically by blood eosinophils, serum @entity11153 , and serum @entity29074 . @entity29074 seemed more sensitive than @entity11153 as indicator of @entity32 . @entity29074 demonstrated some perennial eosinophil activity in hay @entity221 @entity1 , increasing locally during spring.

title: Eosinophil markers in XXXX . Intranasal @entity5023 inhibits local and systemic increases during the pollen season.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'allergic inflammation']

entities_list: @entity29074 :: ('8288', 'Gene') :: ['eosinophil peroxidase', 'EPO']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['seasonal allergic rhinitis']

entities_list: @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone propionate']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['seasonal allergic rhinitis']


abstract: @entity11986 , although not infrequent at autopsy, is seldom identified in life, when it may present as a multisystem disease involving lower limbs, kidney, and gastrointestinal (GI) tract. Diagnosis of isolated GI involvement usually requires examination of surgically resected tissue, because recognition by endoscopic GI biopsy is exceptional. We diagnosed @entity14 by biopsy in four @entity1 . All were elderly (68-80 years old) and had generalized @entity1856 , including @entity449 . Three @entity1 had @entity548 with clots or @entity294 , lower abdominal discomfort, and tenderness. Biopsy revealed atheroemboli in a @entity63 ulcer and in @entity6523 . In all three, disease resolved on conservative management and did not recur during the period of follow-up. In the fourth @entity1 , asymptomatic @entity11986 was identified in an @entity6523 at the @entity4558 . @entity66 attributable to @entity11986 was not present in any of the @entity1 . @entity11986 with manifestations confined to the colon may sometimes be diagnosed by biopsy, appears to be more frequent than currently recognized, and may present a diagnostic challenge as a self-limited episode of @entity548 .

title: Bleeding due to @entity14 . Diagnosis by biopsy of XXXX or of @entity63 ulcer.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysms']

entities_list: @entity11986 :: ('MESH:D017700', 'Disease') :: ['Atheroembolism', 'atheroembolism']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['rectal bleeding', 'sudden onset of frank rectal bleeding']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['rectal ischemic']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Extraintestinal disease']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['bloody diarrhea']

entities_list: @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic flexure']

entities_list: @entity6523 :: ('MESH:D018256', 'Disease') :: ['colorectal adenomatous polyps', 'adenomatous polyp']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal atheroembolism']

answer: @entity6523 :: (MESH:D018256,Disease) :: ['adenomatous polyps']


abstract: PURPOSE OF THE STUDY: The aim of the study was to analyse the long-term clinical and radiographic results of @entity572 ( @entity572 ) with the Bicontact-Plasmacup prosthesis, MATERIAL AND METHODS: In this retrospective observational study, 34 consecutive @entity1 undergoing Bicontact-Plasmacup @entity572 between August 1998 and July 2000 were evaluated. The group included 15 @entity1 and 19 @entity1 with an average age of 56 years (30 to 67 years). The mean    SD of follow-up was 132    9 months (122 to 149 months). @entity1 ' satisfaction with the treatment outcome and selected clinical and radiographic features were evaluated. The data were analysed using the concordance test, Spearman's correlation coefficient and chi-square test. RESULTS: At the final follow-up, 94% of the interviewed @entity1 reported satisfaction with the surgery outcome. The mean Harris score was 93 (67 to 98) points, with excellent or very good results in 91% of the @entity1 . Compared with the post-operative radiographs, the mean    SD value for vertical migration of the acetabular cup was 2.43    3.21 mm (0 to 12 mm) and that for horizontal migration was 0.35    1.0 mm (0 to 4.3 mm). The mean stem subsidence was by 3.87 mm (range, 0.36 to 21.11 mm; SD 4.03). At the final follow-up, all implants showed radiographic stability and absence of radiolucent lines. Early acetabular @entity3061 was detected in two @entity1 (5.9 %). In 19 @entity1 (56%) a change in bone architecture, similar to alterations due to weight-bearing adaptation, was seen around the cup following surgery. The stress shielding effect of the femoral component was recorded in 79%, bypass phenomenon in 41 % and pedestal formation under the apex of the stem in 18% of the @entity1 . The mean rate of @entity691 wear measured by the Dorr and Wan method was 0.106 mm per year (range, 0.00 to 0.267 mm) or it was 0.078 mm per year (0.00 to 0.19 mm) when assessed by a modification of the method described by Kang et al. DISCUSSION: The clinical and radiographic findings presented here are in accordance with the relevant literature data. This implant design is associated with a relatively infrequent @entity3061 around the cup probably due to a low wear rate of @entity691 and a stable @entity691 liner-metal cup interface. Based on this work and some other studies it can be concluded that a post-operative migration of several millimetres is compatible with a long-term, stable cementless @entity572 . CONCLUSIONS: The Bicontact-Plasmacup @entity572 meets the National Institute for Health and Clinical Excellence (NICE) criteria for a very good implant (ten-year survival rate of over 90%). At 10 years after surgery, however, the first signs of complaints about surgery outcome // dissatisfaction with surgery outcomes were recorded. This may, at least partly, be related to @entity1349 which is one of the symptoms of @entity66 .

title: [Cementless Plasmacup-Bicontact XXXX . Results of a minimum of ten-year follow-up].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['polyethylene']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['particle disease']

entities_list: @entity3061 :: ('MESH:D010014', 'Disease') :: ['osteolysis']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['aseptic loosening']

answer: @entity572 :: (MESH:D006617,Disease) :: ['total hip arthroplasty']


abstract: BACKGROUND: Although @entity1124 (PDAC) manifests as a relatively uniform histomorphological feature of the pancreatobiliary type, it may be complicated by metaplastic changes and heterogeneous gastric and intestinal elements. This study aimed to investigate the complication rate and clinicopathological significance of such heterogeneous elements. METHODS: Fifty-nine @entity1 who underwent resection of PDAC were examined in this study. Immunohistochemically, @entity5 showing high expression (>25%) of the intestinal-type (INT) marker @entity6628 were classified as PDAC with INT. Those with high expression (>25%) of the gastric-type (GAS) marker @entity5089 were classified as PDAC with GAS, while those with high expression of both markers were classified as PDAC with INT/GAS. These @entity1 were compared with those with PDAC of the negative group in which neither markers was highly expressed to examine their clinicopathological significance. RESULTS: In the 59 @entity1 , 31 (52.5%) showed high @entity6628 or @entity5089 expression. Twenty-eight @entity1 (47.5%) belonged to a negative group, 11 (18.6%) to a PDAC with INT group, 15 (25.4%) to a PDAC with GAS group, and 5 (8.5%) to a PDAC with INT/GAS group. No significant differences were observed for age, gender, size, localization, T classification, or prognosis among the four groups. Although the PDAC with GAS group had well differentiated types significantly more than the other groups, the rate of lymph node @entity3 in this group was significantly higher (PDAC with GAS: 73%; other groups: 36%). CONCLUSION: Complications with heterogeneous elements are not uncommon in PDAC, and this should be considered during the diagnosis and treatment of PDAC along with histogenesis of the disease.

title: Gastric- and intestinal-type marker expression in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['invasive ductal adenocarcinoma of the pancreas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1124 :: (MESH:D021441,Disease) :: ['invasive ductal adenocarcinoma of the pancreas']


abstract: We investigated cellular responses in a @entity95 to i.v. administration of five established chemotactic factors (leukotriene B4 (LTB4), platelet-activating factor ( @entity5567 ), C5a, @entity14915 (F-MLF), and @entity20574 ), and each exerted a characteristic effect on circulating white blood cell levels. All five factors induced a rapid and transient @entity1431 . The blood was nearly devoid of circulating neutrophils 5 min after administration of each chemotactic factor. Other leukocytes were also variably depleted during the leukopenic phase, including eosinophils, basophils, monocytes, and lymphocytes. The lymphocyte numbers remained significantly depressed (approximately 30%) for as long as 3 h after administration of @entity5567 or f-MLF. Each chemotactic factor produced a marked @entity4795 (i.e., 250-400% of baseline levels) after the initial @entity1431 . Eosinophil numbers were elevated along with the neutrophil response in the C5a- and LTB4-treated animals. Basophil levels were significantly elevated only in LTB4-treated animals. The cellular response to @entity5567 , f-MLF, and @entity20574 appeared to be specific for the neutrophils. The kinetic profiles of the @entity4795 induced by @entity5567 (10 micrograms/kg) or @entity14915 (2.5 micrograms/kg) were similar, with maximal responses occurring 3 to 4 h after administration. In contrast, LTB4 (10 micrograms/kg), @entity20574 (2.5 micrograms/kg), and C5a (5 micrograms/kg) induced a more rapid @entity4795 , with peak responses occurring 1 to 1.5 h after injection, and remaining elevated for 3 to 4 h. In all animals the @entity4795 was accompanied by a relative increase in the number of nonsegmented neutrophils (bands), suggesting that a major component of @entity491 is caused by the release of bone marrow reserves. @entity42430 (10 mg/kg), a dual cyclooxygenase/5-lipoxygenase inhibitor, affected neither the @entity1398 nor the @entity4795 induced by C5a, f-MLF, or @entity5567 . The protein synthesis inhibitor @entity4316 also failed to suppress neutrophil responses induced by either C5a or @entity5567 . These results suggest that @entity491 is a common response induced by all neutrophil chemotactic factors. @entity491 appears to be a direct result of the dynamic adaptive response of neutrophils to chemotactic factor stimulation without involvement of a secondary mediator system.

title: Neutrophil chemotactic factors promote XXXX . A common mechanism for cellular recruitment from bone marrow.

entities_list: @entity14915 :: ('CHEBI:53490', 'Chemical') :: ['N-Formyl-Met-Leu-Phe', 'f-MLF']

entities_list: @entity42430 :: ('MESH:C015429', 'Chemical') :: ['Phenidone']

entities_list: @entity4316 :: ('MESH:D003609', 'Chemical') :: ['actinomycin D']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity4795 :: ('MESH:C563010', 'Disease') :: ['neutrophilia']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['Leukocytosis', 'leukocytosis']

answer: @entity491 :: (MESH:D007964,Disease) :: ['leukocytosis']


abstract: Although the induction of irritant contact @entity1909 has been extensively studied for surfactants, the role of the environmental factor water hardness (i.e., @entity460 content) on the induction process has not received attention. Our objective was to investigate differences in surfactant-induced irritant skin reactions from cumulative exposure to 3 different personal cleansing agents and determine whether the @entity146 potential can be affected by the hardness of the water. 2 commonly used exaggerated washing procedures were variously employed to evaluate representative @entity1372 soap, @entity24924 -soap, or synthetic detergent cleansers under conditions where the water hardness varied from 0-grain to 11-grain (gr). Subjects were clinically evaluated for skin dryness, @entity272 , and instrumentally for hydration. Soap binding to skin was quantified using Fourier transform infrared reflectance spectroscopy. Using the more mild wash procedure, skin sites treated under conditions of hard, 11 gr water were significantly drier, had more erythema, and were less hydrated than corresponding sites treated with deionized 0 gr water. All 3 surfactant cleanser behaved similarly. We also found the hardness of the rinse water to be the more significant factor versus that of the wash water. Effect of water hardness on soap binding to skin revealed a similar outcome. Under a more exaggerated wash condition the relationship between water hardness and @entity146 broke down.

title: The influence of hard water ( XXXX ) and surfactants on irritant contact @entity1909 .

entities_list: @entity24924 :: ('MESH:C009546', 'Chemical') :: ['triethanolamine']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['irritation']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin redness']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']