abstract: One of the limiting factors for the successful treatment of @entity4810 due to @entity12108 ( @entity12108 ) is the low (< 20%) and extremely unpredictable rate of @entity52 of their epididymal spermatozoa. The recent demonstration that @entity12108 is a mild form of @entity1577 , almost exclusively involving the genital tract, has prompted us to investigate the hypothesis of whether there could be an association between particular @entity1577 genotype mutations and the in-vitro performance of epididymal sperm. In this study 63 @entity1 with surgically confirmed diagnosis of @entity12108 undergoing microsurgical epididymal sperm @entity1173 (MESA) and @entity52 ( @entity52 ) were evaluated. The genetic screening was carried out on DNA extracted from peripheral lymphocytes and amplified by the polymerase chain reaction. A total of 12 mutations in the @entity1577 transmembrane regulator gene ( @entity5174 ), representing approximately 90% of the total known @entity1577 mutations, were tested. The presence or absence of mutations, as well as the type of mutation found, was correlated with the @entity52 and pregnancy rates. Of the 63 @entity1 examined, 40 (64%) were positive to the @entity1577 screening and 23 were negative. In three cases no spermatozoa were found because of rete testis blockage. The difference in fertilization rates between @entity1 testing positive and negative was highly significant (P = 0.000003), 13 versus 23%, respectively. In order to pinpoint which mutation could account for the most deleterious effect on the @entity52 results, we analysed these by keeping the @entity1 separated by @entity1577 mutations.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Cystic fibrosis mutations impair the fertilization rate of epididymal sperm from XXXX with @entity12108 .

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['male sterility']

entities_list: @entity12108 :: ('MESH:C535984', 'Disease') :: ['congenital absence of the vas deferens', 'CAVD']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['in-vitro fertilization', 'IVF']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis (CF) disease', 'cystic fibrosis', 'CF']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: OBJECTIVE: @entity571 pathogenesis includes both mechanical and inflammatory features. Studies have implicated synovial fluid urate (UA) as a potential @entity571 biomarker, possibly reflecting chondrocyte damage. Whether serum urate (sUA) levels reflect/contribute to @entity571 is unknown. We investigated whether sUA predicts @entity571 progression in a non- @entity210 knee @entity571 population. METHODS: Eighty-eight subjects with medial knee @entity571 (BMI <33) but without @entity210 were included. Baseline sUA was measured in previously banked serum. At 0 and 24 months, subjects underwent standardized weight-bearing fixed-flexion posteroanterior knee radiographs to determine joint space width (JSW) and Kellgren-Lawrence (KL) grades. @entity2720 ( @entity2720 ) was determined as JSW change from 0 to 24 months. Twenty-seven subjects underwent baseline contrast-enhanced 3T knee MRI for synovial volume (SV) assessment. RESULTS: sUA correlated with @entity2720 in both univariate (r=0.40, p<= 0.01) and multivariate analyses (r=0.28, p=0.01). There was a significant difference in mean @entity2720 after dichotomizing at sUA of 6.8 mg/dL, the solubility point for serum urate, even after adjustment ( @entity2720 of 0.90 mm for sUA>= 6.8; @entity2720 of 0.31 mm for sUA<6.8, p<0.01). Baseline sUA distinguished progressors ( @entity2720 >0.2mm) and fast progressors ( @entity2720 >0.5mm) from nonprogressors ( @entity2720 <= 0.0mm) in multivariate analyses (area under the receiver operating characteristic curve 0.63, p=0.03; AUC 0.62, p=0.05, respectively). sUA correlated with SV (r=0.44, p<0.01), a possible marker of @entity2720 , though this correlation did not persist after controlling for age, gender and BMI (r=0.13, p=0.56). CONCLUSIONS: In non- @entity210 @entity1 with knee @entity571 , sUA predicted future @entity2720 and may serve as a biomarker for @entity571 progression. This article is protected by copyright. All rights reserved.

title: Serum Urate Levels Predict Joint Space Narrowing in Non- XXXX @entity1 with Medial Knee Osteoarthritis.

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['Joint space narrowing', 'JSN']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity210 :: (MESH:D006073,Disease) :: ['gout']


abstract: OBJECTIVE: To evaluate the efficacy of whole brain radiotherapy (WBRT) or/and stereotactic radiotherapy (SRT) concomitant with first-generation @entity470 @entity4149 kinase inhibitors (TKI), like @entity3866 and @entity4562 , in the treatment of brain metastases from @entity1149 ( @entity1149 ). METHODS: Comprehensive searches were performed in different databases, including EMBASE, MEDLINE and Cochrane Library, etc. All @entity23 ( @entity23 ) and non- @entity23 (non- @entity23 ) comparing radiotherapy (RT) plus TKI with RT alone in the treatment of brain metastases from @entity1149 were included for meta-analysis with Cochrane Collaboration's RevMan5. 2 software. The primary end-points were objective remission (OR), disease control (DC) and @entity137 while the secondary end-point was overall survival (OS). RESULTS: Three @entity23 and one non-randomized controlled trial were selected and included for final analysis. The RT + TKI group had significant improvements in OR rate (RR = 1. 80, P <0. 01) and DC rate (RR = 1. 31, P <0. 01). Meanwhile, @entity1910 (RR = 14. 36, P = 0. 003) and @entity294 (RR = 3. 49, P = 0. 005) increased in the RT + TKI group. Yet there was no significant difference in @entity390 or @entity391 (P = 0. 20). CONCLUSION: For @entity1149 with brain metastases, RT plus TKI could improve OR, DC and OS, but there was a higher incidence of @entity1910 and @entity294 . There fore future high-quality and prospective @entity23 are warranted to confirm the clinical efficacy of RT plus TKI in the treatment of @entity1149 with brain metastases.

title: [Radiotherapy concomitant with first-generation @entity470 @entity4149 kinase inhibitors in the treatment of brain metastases from XXXX : a meta-analysis].

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib']

entities_list: @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['randomized controlled trials', 'RCTs']

entities_list: @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non small cell lung cancer']


abstract: Two cDNA species encoding sequences homologous to the 65 kDa regulatory subunit ( @entity4330 ) of @entity4331 ( @entity4332 have been isolated from an @entity958 cDNA library. These were designated pDF1 and pDF2. pDF1 is 1795 bp long and by comparison with the @entity1 and porcine @entity4333 regulatory subunit sequences represents a full-length clone. It encodes a predicted polypeptide of 587 @entity3689 residues. pDF2 is truncated at the 5' end by 237 bp. The complete @entity4334 sequences have been determined for both cDNA species. Comparison of the @entity4334 and the deduced @entity3689 sequences showed that the two sequences were homologous but not identical and therefore must be derived from two different genes. Northern blot analysis was performed on total RNA and poly(A)+ RNA isolated from seed at various stages of development and from young leaf material of @entity4335 . ( @entity4335 ). Both cDNA probes hybridised to a single major mRNA species of ca. 2.2 kb. The highest level of expression was observed in the total RNA from developing rape seed at about 33 days after flowering, and the transcript level in the poly(A)+ RNA of the seed was higher than in young leaf of @entity4335 . Southern blot analysis was performed on two varieties of A. thaliana and @entity4335 genomic DNA; this identified a small family of genes in A. thaliana consisting of at least 2 or 3 members and a larger multigene family in @entity4335 of at least 5 or 6 members. Two independent genomic clones were isolated from an A. thaliana genomic library. Sequencing of a fragment common to both revealed that the sequence was identical in both clones and, therefore, they were assumed to contain the same genomic sequence. The genomic sequence selected, designated regA, is 3639 bp long and the coding sequence contains eleven introns. The gene encodes a predicted polypeptide of 590 @entity3689 residues. The sequence comparison with both cDNA sequences showed that it is homologous but not identical to the two, confirming that at least three different genes exist in A. thaliana which encode PR65 of @entity4333 .

title: Characterisation of cDNA and genomic clones encoding homologues of the @entity4330 in XXXX .

entities_list: @entity4335 :: ('3708', 'Species') :: ['Brassica napus L', 'B. napus', 'oilseed rape']

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis thaliana']


abstract: Poor survival of mesenchymal stem cells (MSCs) compromised the efficacy of stem cell therapy for @entity583 . The increase of exogenous reactive @entity26 species (ROS) in infracted heart is one of the important factors that challenged the survival of donor MSCs. In the study we aimed to evaluate the effect of oxidative stress on the cell death of MSCs and investigate its mechanisms in order to help with the identification of new biological compounds to reduce donor cells damage. Apoptosis of MSCs were evaluated with @entity5956 staining and flow cytometry analysis. The mitochondrial membrane potential of MSCs was analyzed with JC-1 staining. Signaling pathways involved in @entity274 induced apoptosis were analyzed with Western blot. @entity274 induced apoptosis of MSCs in a dose- and time-dependent manner. @entity274 induced apoptosis of MSCs via both endoplasmic reticulum (ER) and mitochondrial pathways rather than extrinsic apoptosis pathway. @entity274 caused transient rather than sustained activation of @entity3963 and @entity4675 with no effect on @entity1366 pathway. @entity3963 was involved in the regulation of early apoptosis of MSCs while @entity4675 was involved in the late apoptosis. @entity3963 directed both ER stress and mitochondria death pathway in the early apoptosis. In conclusion, exogenous ROS was a major factor to induce apoptosis of MSCs. Both ER stress and mitochondria death pathway were involved in the apoptosis of MSCs. @entity274 activated @entity3963 that directed the above two pathways in the regulation of early apoptosis of MSCs while @entity4675 was involved in the late apoptosis of MSCs.

title: Apoptosis of mesenchymal stem cells induced by hydrogen peroxide concerns both endoplasmic reticulum stress and mitochondrial death pathway through regulation of caspases, @entity3963 and XXXX .

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity4675 :: (5599,Gene) :: ['JNK']


abstract: BACKGROUND: Peak @entity26 consumption (peak @entity4962 ) and late @entity2287 enhancement (LGE) on cardiovascular magnetic resonance (CMR) are prognostic in @entity712 . We investigated whether LGE-CMR and peak @entity4962 combined had additive value in risk stratifying @entity1 with @entity384 ( @entity384 ). METHODS: Fifty-seven @entity384 @entity1 underwent CMR and cardiopulmonary exercise testing. @entity299 were @entity204 , hospitalization for decompensated @entity712 , or lethal @entity943 . RESULTS: Twenty-five (44%) were LGE positive. The median peak @entity4962 was 18.5 mL/kg/min. On multivariate analysis, positive LGE (P = 0.048) and peak @entity4962 (P = 0.003) were independent cardiac event predictors. Cardiac event risk was significantly higher with positive LGE and peak @entity4962 <18.5 mL/kg/min than with negative LGE and peak @entity4962 >= 18.5 mL/kg/min (hazard ratio 12.5; 95% CI 1.57-100; P = 0.017). In three @entity1 groups (group A: no LGE, peak @entity4962 >= 18.5 mL/kg/min, n = 18; group B: positive LGE or peak @entity4962 <18.5 mL/kg/min, n = 24; group C: positive LGE and peak @entity4962 <18.5 mL/kg/min, n = 15) during follow-up (71    32 months), group C had higher cardiac event rates than the others. CONCLUSIONS: Combined assessment of LGE-CMR and peak @entity4962 provides additive prognostic information in ambulatory @entity384 .

title: Prognostic Impact of Combined Late XXXX Enhancement on Cardiovascular Magnetic Resonance and Peak @entity26 Consumption in Ambulatory @entity1 with @entity384 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'nonischemic dilated cardiomyopathy']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Cardiac events']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']

answer: @entity2287 :: (MESH:D005682,Chemical) :: ['Gadolinium']


abstract: OBJECTIVE: Several lines of evidence suggest that the GH- @entity442 axis affects capillary permeability and angiogenesis. We evaluated skin capillary permeability and capillary density in @entity2338 adults, before and after GH replacement therapy. @entity1 : Seven normotensive, nondiabetic @entity2338 adults (two @entity1 ) were matched with 14 control subjects. MEASUREMENTS: Large-window videodensitometry with @entity941 was performed in all subjects. Capillary permeability was expressed as the average relative light intensity over the first 7 min after the appearance of @entity941 in the skin capillaries; Iav(7). Skin capillary density was determined by counting the visualized capillaries and was expressed as n/mm2. The @entity2338 @entity1 were restudied after 12 months of GH replacement therapy (2 U/day). RESULTS: Both capillary permeability and capillary density were lower in untreated @entity2338 @entity1 than in control subjects (median, interquartile range): Iav(7) in @entity2338 @entity1 47.1 (45.1-52.2)% vs. 57.5 (50.5-64.8)% in controls, P < 0.05; capillary density in @entity2338 @entity1 18 (12-24)/mm2 vs. 32 (26-36)/mm2 in controls, P < 0.05. GH treatment normalized plasma @entity442 from 4.3 (1.0-13.4) to 22.2 (19.8-48.2) nmol/l (P < 0.05). Furthermore, both capillary permeability [Iav(7) 53.1 (48.8-58.4)%, P < 0.05] and capillary density [26 (17-34)/mm2, P < 0.05] increased to a level that was not different from that in control subjects. CONCLUSIONS: The present study demonstrates that the growth hormone @entity465 is associated with microvascular alterations, which are responsive to growth hormone replacement therapy.

title: Reduced capillary permeability and capillary density in the skin of XXXX adults: improvement after 12 months GH replacement.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS']

entities_list: @entity2338 :: ('MESH:D004393', 'Disease') :: ['GH-deficient']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['deficiency syndrome']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['sodium fluorescein', 'fluorescein']

answer: @entity2338 :: (MESH:D004393,Disease) :: ['GH-deficient']


abstract: OBJECTIVE: The aim of this study was to determine the incidence rate of lower-extremity @entity4269 after systematic lymphadenectomy in @entity1 with uterine @entity5 and to elucidate risk factors for this type of @entity4269 . METHODS: A retrospective chart review was carried out for all @entity1 with uterine corpus malignant @entity5 managed at Hokkaido Cancer Center between 1991 and 2007. @entity1 who did not undergo lymphadenectomy as a treatment or died of @entity5 /intercurrent disease were excluded from this study. All living @entity1 included in this study had hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. We identified @entity1 with postoperative lower-extremity @entity4269 (POLEL). Logistic regression analysis was used to select the risk factors for POLEL. RESULTS: Of 286 @entity1 evaluated, 103 (37.8%) had POLEL. Multivariate analysis confirmed that adjuvant radiation therapy (OR=5.2, 95% CI=2.1-12.7), resection of more than 31 lymph nodes (OR=2.6, 95% CI=1.4-4.9), and removal of circumflex iliac nodes to the distal external iliac nodes (CINDEIN) (OR=6.1, 95% CI=1.3-28.2) were independent risk factors for POLEL. CONCLUSION: Adjuvant radiation therapy should be avoided in @entity1 who undergo systematic lymphadenectomy if an alternative postoperative strategy is possible. Although reducing the number of resected lymph nodes is not appropriate from a therapeutical point of view, elimination of CINDEIN dissection may be helpful in reducing the incidence of POLEL. The clinical significance of CINDEIN dissection needs to be investigated by a randomized controlled trial.

title: Risk factors for postoperative lower-extremity XXXX in endometrial cancer survivors who had treatment including lymphadenectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'corpus malignancies']

answer: @entity4269 :: (MESH:D008209,Disease) :: ['lymphedema']


abstract: The prevalence of @entity1907 in 809 residents of 11 old-age homes for whites and 1 for coloureds in East London, CP, was investigated in a cross-sectional study. A Mantoux test, chest radiography, an enzyme-linked immunosorbent assay (ELISA) and sputum culture were used. The diagnosis was made on sputum culture in 12 subjects. The Mantoux test was positive in 7 of these subjects, and in 25% of the population. The ELISA on adsorbed sonicated mycobacterial antigen had a positive predictive value of 13% and probably has no diagnostic value for @entity66 in this population. Of the subjects with a positive diagnosis 1 had a normal chest radiograph; 10 had minimal basal inflammatory infiltrates or patchy fibrotic changes, and 1 had evidence of classic reactivation of old @entity75 . The national incidence of @entity378 in the low-risk white population is 16/100,000. In old-age homes for whites, however, the overall case rate was 798/100,000 (a 50-fold increase), and in one home where there was a cluster of cases, it was 6,849/100,000. In the home for coloureds the prevalence was 10,344/100,000. This confirms other studies showing that elderly @entity1 living in old-age homes are at particular risk of developing @entity378 . Males appear to be at higher risk than females. Recommendations regarding the diagnosis and control of @entity378 in the elderly in institutions and in old-age homes are made.

title: XXXX in geriatric homes.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['tubercular disease']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['apical lesions']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis']

answer: @entity1907 :: (MESH:D014397,Disease) :: ['Epidemic of pulmonary tuberculosis']


abstract: A 22-year-old @entity1 complained of sudden, @entity1018 (vague @entity1019 in central vision) in his right eye. The @entity1 became symptomatic following a session of weight training at a gymnasium the previous day. There was no history trauma. Medical, ocular and familial history were unremarkable. The inferior and temporal aspect of the @entity548 was darker due to gravitation, but the rest of the fundus was normal. The appearance of the right fundus, combined with an associated unequivocal history of physical exertion, was consistent with a diagnosis of @entity1020 (holding breath while bench pressing). Systemic examination and all relevant blood tests were normal. Fluorescein angiography (FFA) was done which confirmed the diagnosis. The @entity1 recovered a vision of 6/6 in his right eye after 2 months. FFA was again done, which showed no sequelae of the problem.

title: @entity1020 : a rare association of the Valsalva manoeuvre ( XXXX ).

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['painless loss of vision']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['Valsalva maculopathy']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['Valsalva maculopathy']


abstract: UNASSIGNED: 5026 Background: It has been accepted that 5-10% of all @entity43 cases can be attributed to hereditary pathogenic mutations in @entity5 predisposition genes. Consequently genetic testing is mostly offered to those @entity1 who also have a strong family history of relevant @entity5 or specific ancestry. We investigated the frequency and clinical characteristics, including the treatment response to @entity902 therapeutics, of germline @entity6069 pathogenic mutation carriers in a large population-based prospective cohort of Australian @entity1 with @entity43 . METHODS: @entity1 were ascertained from the Australian @entity43 Study which recruited @entity1 presenting for surgery for @entity43 between 2002-2006. @entity1 were eligible for @entity6069 genotyping if diagnosed with @entity43 . Mucinous histology was excluded from analysis. Full @entity5345 and @entity2674 analysis was done by gene sequencing and multiplex ligation-dependent probe amplification. Germline status was related to @entity5 features, clinical response and potential familiality in first degree relatives, including incidences of early onset @entity0 . RESULTS: 134 pathogenic germline mutations were identified within the cohort, for an overall mutation frequency of 13.3% in the Australian @entity43 population. 113 (84.3%) mutations were associated with serous histology. 57% of mutation carriers had no evidence of familiality. Mutation carriers were more responsive to primary @entity902 treatment than non-carriers (87.4% had >6 months progression free survival, versus 68.4%), and were more likely to respond to @entity902 upon relapse (86% of mutation positive @entity1 responded to secondary @entity902 after relapsing <6 months after primary @entity902 treatment versus 60% of mutation negative @entity1 ). CONCLUSIONS: Pathogenic @entity6069 mutations are common in invasive @entity43 and are associated with improved overall survival and response to systemic chemotherapy. @entity5345 testing should be implemented for all @entity43 @entity1 as mutation status has important prognostic and therapeutic clinical utility.

title: Germ-line @entity5345 mutations in high-grade XXXX : A case for routine @entity5345 mutation screening after a diagnosis of invasive @entity43 .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Ovarian Cancer', 'ovarian cancer', 'invasive epithelial ovarian, peritoneal or fallopian tube tumors', 'invasive epithelial ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'Participants']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: Adaptive radiation therapy (ART) is the next improvement in image-guided radiation therapy (IGRT). ART consists in changing treatment delivery to compensate for changes in @entity1 anatomy or @entity5 volume. The treatment planning is therefore adapted to the new target volume. By daily imaging, the @entity5 volume can be assessed and compared with the initial volume. In case of @entity5 progression or @entity5 response, a new plan can be obtained to adequately treat the new volume. We report the use of ART with the Plan Adaptive software of TomoTherapy Inc. in a @entity1 with massive @entity0 recurrence in the axilla. Between the CT simulation and the first day of radiotherapy the axillary lesion progressed. Megavolt CT performed to image-guide the treatment showed impressive growth of the lesion, which went out of the treatment field. By studying the dose distribution on the new anatomy, we found that the planning target volume was substantially undercovered by the prescription dose. Adaptive planning was performed using the anatomical information acquired by the megavolt CT.

title: Adaptive radiation therapy in a @entity1 with a massive nodal XXXX recurrence.

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: In vitro mutagen binding ability of @entity1 @entity10263 231 (Lr 231) was evaluated against @entity9186 (AO), @entity2482 ( @entity2482 ), @entity11842 ( @entity11842 ) and @entity11843 ( @entity11844 ). Binding of AO by Lr 231 is due to adsorption, thereby leading to removal of mutagen in solution and is instantaneous, pH- and concentration-dependent. Whereas, binding of @entity2482 and @entity11842 by Lr 231 results into biotransformation leading to detoxification with subsequent loss of mutagenicity as determined by spectral analysis, thin layer chromatography and Ames test. Binding of mutagen by Lr 231 was dependent on culture age and optimum binding of AO, @entity2482 and @entity11842 was observed to occur with 24 h old culture. Cells of Lr 231 were subjected to different chemical treatments prior to binding studies. Results indicated cell wall component such as cell wall polysaccharide, peptidoglycan, @entity3363 and proteins plays an important role in adsorption of AO, also involving hydrophilic and ionic interactions. Binding, biotransformation and detoxification of @entity2482 and @entity11842 by Lr 231 was dependent on cell surface characteristics mainly involving @entity3363 , proteins, @entity11845 /lipoteichoic acid, hydrophobic interaction and presence of @entity1432 group. @entity10263 231 bound @entity2482 instantaneously. More than 96 (p < 0.01) and 70% (p < 0.05) cells remained viable after mutagen binding and various pretreatments respectively. This study shows Lr 231 exhibits ability to bind and detoxify potent mutagens, and this property can be useful in formulating fermented foods for removal of potent mutagens.

title: In vitro mutagen binding and antimutagenic activity of @entity1 XXXX 231.

entities_list: @entity2482 :: ('MESH:D008769', 'Chemical') :: ['MNNG', "N-methyl-N'-nitro-N-nitrosoguanidine"]

entities_list: @entity11842 :: ('MESH:C036990', 'Chemical') :: ['MeIQx', '2-amino-3, 8-dimethylimidazo-[4,5-f]-quinoxaline']

entities_list: @entity10263 :: ('47715', 'Species') :: ['Lactobacillus rhamnosus', 'L. rhamnosus']

entities_list: @entity11843 :: ('MESH:C012277', 'Chemical') :: ['4-nitro-o-phenylenediamine']

entities_list: @entity11845 :: ('CHEBI:30049', 'Chemical') :: ['teichoic acid']

entities_list: @entity9186 :: ('MESH:D000165', 'Chemical') :: ['acridine orange']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity10263 :: (47715,Species) :: ['Lactobacillus rhamnosus']


abstract: BACKGROUND: We evaluated 35% @entity1133 in a water-lipid-based foam delivery system containing @entity880 in @entity1 with mild-to-moderate xerosis of the foot. METHODS: This 4-week open-label study enrolled 12 @entity1 with xerosis of the foot; six @entity1 were @entity6 and six were nondiabetic. Study medication was applied to the affected area twice daily. All adverse events were recorded. Disease severity was measured at baseline and at the end of treatment by Investigator's Global Assessment, and investigator's and @entity1 's signs and symptoms scores. At 4 weeks, compliance and @entity1 satisfaction were determined from @entity1 diaries and a 16-item survey instrument, respectively. RESULTS: Ten @entity1 completed the study. No adverse reactions were noted with application of the foam. All of the @entity1 who completed the study experienced an improvement in xerosis. The median Investigator's Global Assessment score decreased significantly from baseline to the end of treatment (P = .005). The investigator and @entity1 observed significant improvement (P < .05) in redness, scaling, and cracking from baseline to the end of treatment. Compliance with the regimen was good, and @entity1 expressed satisfaction with the product. CONCLUSIONS: Thirty-five percent @entity1133 in a water-lipid-based foam delivery system containing @entity880 can be an appropriate treatment option for mild-to-moderate xerosis of the foot.

title: Clinical evaluation of 35% @entity1133 in a water-lipid-based foam containing XXXX for treatment of mild-to-moderate xerosis of the foot.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

answer: @entity880 :: (MESH:D019344,Chemical) :: ['lactic acid']


abstract: STUDY OBJECTIVE: To evaluate the efficacy of @entity2897 , @entity2898 , and @entity2899 in preventing @entity2900 -induced @entity2901 and @entity282 in @entity1 undergoing ambulatory surgery. DESIGN: Randomized, prospective, placebo-controlled trial SETTING: Teaching hospital. SUBJECTS: 80 ASA physical status I and II @entity1 scheduled for elective ambulatory surgery with general anesthesia. INTERVENTION: A standardized balanced anesthetic technique was used for all @entity1 . MEASUREMENTS AND MAIN RESULTS: @entity1 were randomized to receive @entity2897 0.01 mg/kg, @entity2898 0.06 mg/kg, @entity2899 0.05 mg/kg, or saline, 3 minutes prior to intravenous (i.v.) @entity2900 1.5 mg/kg. The intensity of @entity2901 and intubating conditions were assessed using a four-point rating scale. In addition, the severity of @entity925 was assessed using a four-point rating scale in the postanesthesia care unit and at 24 hours postoperatively. No @entity1 complained of any side effects after the administration of the study drug. @entity2901 were observed less frequently (p < 0.05) in the @entity2899 and @entity2898 groups compared with the placebo and @entity2897 groups. However, there was no difference between the @entity2899 group and the @entity2898 group (21% vs. 10%, respectively). Although @entity2901 occurred less frequently in the @entity2897 group than in the placebo group (59% vs. 85%, respectively), this difference did not reach statistical significance. There was no difference among the four groups in the intubating conditions or the incidence of @entity282 . CONCLUSION: Pretreatment with @entity2898 and @entity2899 was superior to @entity2897 in preventing @entity2900 -induced @entity2901 . However, pretreatment did not have any effect on the incidence of @entity925 after ambulatory surgery.

title: Effects of pretreatment with @entity2897 , @entity2898 , and @entity2899 on XXXX -induced @entity2901 and @entity925 : a comparison with placebo.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative myalgia']

entities_list: @entity2898 :: ('MESH:C061870', 'Chemical') :: ['rocuronium']

entities_list: @entity2901 :: ('MESH:D005207', 'Disease') :: ['Fasciculations', 'fasciculations']

entities_list: @entity2899 :: ('MESH:D014403', 'Chemical') :: ['d-tubocurarine']

entities_list: @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium']

entities_list: @entity2900 :: ('MESH:D013390', 'Chemical') :: ['succinylcholine']

answer: @entity2900 :: (MESH:D013390,Chemical) :: ['succinylcholine']


abstract: A 49-year old @entity1 had an eruption resembling 'dermatite pustuleuse chronique en foyers a progression excentrique' as initially described by @entity4240 . Numberous vegetating @entity75 occurred over the genitocrural, pubic, umbilical and submammary regions. The finger-nails showed onycholysis and sterile pustules. No bullae were seen at any time. Histopathological study revealed the presence of acantholysis. Direct immunofluorescent microscopy showed IgG deposits in the intercellular epidermal space. The titer of pemphigus antibody was 1/1,600: the results of these immunofluorescence studies on early @entity75 as well as vegetating @entity75 support the view that @entity4240 belongs to the 'pemphigus group'. The @entity1 was treated first with oral @entity229 (80 mg/day). In twelve months of follow-up care, the vegetating @entity75 disappeared completely, leaving @entity2117 . Prompt recurrence of @entity75 was observed when @entity288 were discontinued; reinstitution of this therapy was followed by their regression. A difference exits between @entity7271 and @entity7271 : (1) the @entity4240 type begins with pustules as the primary @entity75 , followed by @entity47 , with a lack of bullae and a preference for flexural areas. Immunofluorescence studies will be the deciding factor in separating @entity7271 from @entity6793 . (2) The Neumann type is a variant of @entity7271 in which the denuded areas have a tendency to heal with @entity11536 formations. It begins and ends with bullae.

title: [ @entity7271 , a clinical type of chronic pustular dermatitis of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity11536 :: ('MESH:D058066', 'Disease') :: ['papillomatous']

entities_list: @entity7271 :: ('MESH:D010392', 'Disease') :: ['pemphigus vulgaris', 'pemphigus vegetans of Neumann', 'pemphigus vegetans of Hallopeau']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['lesions', 'pustular lesions']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation']

entities_list: @entity4240 :: ('MESH:D016108', 'Disease') :: ['Hallopeau', 'Hallopeau disease']

entities_list: @entity47 :: ('MESH:D018458', 'Disease') :: ['vegetations']

entities_list: @entity6793 :: ('MESH:D011711', 'Disease') :: ['pyoderma vegetans']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity4240 :: (MESH:D016108,Disease) :: ['Hallopeau']


abstract: Enterotoxigenic @entity526 ( @entity17052 ) infection is the most common type of porcine @entity22131 ( @entity22131 ). Among fimbriae of porcine @entity17052 strains the best studied family of fimbriae are the members of F4 adhesins, existing in at least three variants: ab, ac, ad. Active immunization against porcine @entity22131 is difficult due to: i) @entity17052 strains are only one of the essential predisposing factors, ii) the success of vaccinal antigen uptake depends on the presence of enterocyte receptors for F4 adhesins, iii) the intestinal immune system may react with tolerance or @entity56 to the same antigens depending on the dose and form of the vaccinal immunogen, and iv) kinetics of the specific immune responses may be different in the case of F4 (earlier) and the other @entity17052 adhesins, particularly F18 (later). The aim of this study was to test the effectiveness of a live attenuated F4ac+ non- @entity17052 vaccine against porcine @entity22131 by analyzing quantitative differences in the small intestinal lymphoid and myeloid cell subsets of immunized (with or without @entity7305 given as an adjuvant) vs control non-immunized @entity1707 . Four week-old @entity1707 were intragastrically immunized with a vaccine candidate F4ac+ non- @entity17052 strain 2407 at day 0, challenged 7 days later with a virulent F4ac+ strain @entity17052 11-800/1/94, euthanatized at day 13 and sampled for immunohistology. Non-immunized @entity1707 received saline at day 0 and were processed as the principals. Immuno-phenotypes of lymphoid and myeloid cell subsets were demonstrated within jejunal and ileal mucosa by immunohistochemical avidin- @entity1885 complex method and corresponding morphometric data were analyzed using software program Lucia G for digital image analyses. Monoclonal antibodies reactive with surface molecules on porcine immune cells such as @entity22932 , CD45RA, CD45RC, CD21 and @entity24789 enabled clear insight into distribution patterns and amount of these cells within the gut-associated lymphoid tissues (GALT) examined. The numbers of jejunal and ileal cell subsets tested were significantly increased (at P<0.5 or lower) in both principal groups (vaccinated or levamisole primed-vaccinated) of @entity1707 , compared to those recorded in the control non-vaccinated @entity1707 . Based on the histomorphometric quantification of porcine intestinal immune cells from the GALT compartments tested, it is possible to differentiate the responses of @entity1707 immunized by an experimental mucosal vaccine from those of non-immunized @entity1707 .

title: Histomorphometric evaluation of intestinal cellular immune responses in @entity1707 immunized with live oral F4ac+ non-enterotoxigenic @entity526 vaccine against XXXX .

entities_list: @entity7305 :: ('MESH:D007978', 'Chemical') :: ['levamisole']

entities_list: @entity22131 :: ('MESH:D053570', 'Disease') :: ['PWC', 'postweaning colibacillosis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity22131 :: (MESH:D053570,Disease) :: ['postweaning colibacillosis']


abstract: OBJECTIVES: To develop a nomogram that allows the prediction of disease recurrence using preoperative clinical factors for @entity1 with clinically localized @entity263 who are candidates for laparoscopic radical prostatectomy. Few published studies have combined the clinical prognostic factors into risk profiles that can be used to predict the likelihood of recurrence or metastatic progression after laparoscopic radical prostatectomy for @entity263 . METHODS: Using Cox proportional hazards regression analysis, we modeled the clinical data and disease follow-up data for 2272 @entity1 with clinically localized @entity263 who had undergone laparoscopic radical prostatectomy. The clinical data included the pretreatment serum @entity1486 level, biopsy Gleason grade, clinical stage, number of positive cores, and number of negative cores. Treatment failure was recorded when clinical evidence of disease recurrence was present, the serum @entity1486 level had increased (2 measurements of >= 0.1 ng/mL and increasing), or the initiation of adjuvant therapy. Validation was also performed on an external data set of 1151 @entity1 . RESULTS: Treatment failure was noted in 229 of the 2272 @entity1 . The group without failure had a median follow-up of 16.7 months (range 0-120.6). The concordance index, when the nomogram was applied to the validation data set, was 0.77. The calibration in this data set was adequate. The predictions from this nomogram were more accurate than those using an open prostatectomy nomogram. CONCLUSIONS: We have externally validated a nomogram that predicts the 5-year probability of treatment failure among @entity1 with clinically localized @entity263 treated with laparoscopic radical prostatectomy.

title: Development and validation of preoperative nomogram for disease recurrence within 5 years after laparoscopic radical prostatectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: A classification of @entity740 ( @entity740 ) based on stages of glomerular filtration (GF) has recently been developed. Thus, @entity177 ( @entity177 ) is based on GF <60 ml/min. Our goal was to study the presence of typical manifestations of @entity177 in elderly individuals with a GF of <60 ml/min (stage 3-5) and to determine the cut-off value at which GF can be used to detect these manifestations. MATERIAL AND METHODS: We performed a cross-sectional study in clinically-stable elderly @entity1 attending the geriatrics and nephrology outpatient department. The estimated GF (GFe) was established with the Cockroft-Gault and abbreviated @entity8 ( @entity8 ) formulae. Because these @entity1 had a GF of less than 60 ml/min, they were expected to show the manifestations associated with @entity177 ( @entity417 , @entity520 , @entity2331 ). We evaluated the occurrence of these manifestations and the GF cut-off at which they were detected. To do this, the population was divided into two groups: group A: @entity1 with GFe > or = 30 ml/min (stage 3, N=48); and group B: @entity1 with GFe <30 ml/min (stages 4-5, N=8). RESULTS: Seventy percent of the @entity1 had a GFe ( @entity8 ) <60 ml/min (stage 3-5). Despite reduced GF, these @entity1 did not show the typical manifestations of @entity177 . Group B showed higher plasmatic levels of @entity1011 , @entity1133 , @entity414 , and @entity972 and required treatment with erythropoietin and @entity460 salts. CONCLUSIONS: Many elderly @entity1 diagnosed with @entity740 with the current classification do not show manifestations of @entity177 . Estimation of the GF in elders should be generalized to correctly adjust medication to @entity8 rather than to classify elders into @entity740 stage.

title: [Laboratory manifestations associated with XXXX : what degree of estimated glomerular filtration can be used for its detection in the elderly?].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['MDRD', 'renal impairment', 'Modification of Diet in Renal Disease Study']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure', 'CRF']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['abnormal bone and mineral metabolism']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']


abstract: AIM: The aim of this study was to evaluate the role of explorative laparoscopy to evaluate candidates for complete resection of peritoneal @entity189 (PC) combined with hyperthermic intraperitoneal chemotherapy (HIPC). METHODS: The database of the surgical department of the Institut Gustave Roussy was used to select 113 @entity1 planned to undergo a maximal cytoreductive surgery combined with HIPC for PC between April 2001 and July 2003. Among them, 11 underwent an explorative laparoscopy because extent of the PC was insufficiently documented to evaluate its resectability. @entity1 records were retrospectively reviewed. RESULTS: Laparoscopic evaluation was successful in all 11 @entity1 . The median operating time was 38 min (range 23-75 min). The laparoscopic examinations were well tolerated in all cases. The median length of hospital stay was 1.7 days. For three @entity1 , the PC was as judge as unresectable. A complete resection of the PC combined with HIPC was performed in seven out of the eight @entity1 with PC considered resectable at laparoscopy. One @entity1 was diagnosed with more extensive disease than that as assessed by the evaluative laparoscopy. Of note, for 20% of the @entity1 with straight away laparotomy, the complete cytoreduction was not possible. CONCLUSION: Laparoscopic scoring of peritoneal @entity189 is accurate to assess the complete resectability of PC in @entity1 for which there is inadequate or contradictory information concerning disease extent.

title: The role of laparoscopy to evaluate candidates for complete cytoreduction of peritoneal XXXX and hyperthermic intraperitoneal chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'patient']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinomatosis']


abstract: Immune responses of 4 inbred lines of @entity1573 , that differ in resistance to Eimeria maxima and @entity12917 , were examined. Significant differences were found in in vitro proliferation of peripheral blood lymphocytes to E. maxima sporozoite antigen, the more resistant lines C and 7(2) having higher responses than the more susceptible line 15I. These differences existed @entity281 and were enhanced following both primary and a second @entity281 . The proportions of lymphocyte subsets in the peripheral blood following @entity281 also differed between lines, with significantly higher percentages of CD8+ and TCR1 + lymphocytes circulating in the more resistant birds. In contrast, there were few differences between lines in either resistance or in in vitro proliferation of peripheral blood lymphocytes to E. tenella sporozoite antigen either @entity281 or following a @entity281 . However, after a second @entity281 when there were significant differences in resistance between lines, as measured by oocyst excretion, there were also significant differences in lymphoproliferation with the more resistant lines 15I and 6(2) having higher responses than the more susceptible line C. Thus for E. maxima there is a direct relationship between resistance to @entity281 and lymphoproliferation in response to parasite antigen. This implies that differences in cellular immunity may account for differences in resistance between lines, and since these specific responses are enhanced by @entity281 they may also reflect important immune mechanisms. For the rather less immunogenic @entity12917 , the correlation between resistance and lymphoproliferation is not so clear. However, where there were significant differences between lines, i.e. after a second @entity281 , the direct relationship between resistance and lymphoproliferation was upheld.

title: Comparison of immune responses in inbred lines of @entity1573 to Eimeria maxima and XXXX .

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['pre-infection', 'infection', 'primary infection']

answer: @entity12917 :: (5802,Species) :: ['Eimeria tenella']


abstract: Activating @entity4016 @entity4017 mutation is present in many @entity1 with @entity5 . We evaluated, retrospectively, clinical and laboratory data from 70 @entity1 with BCR-ABL1 negative, @entity4016 positive, @entity102 . Quantity of the @entity4016 mutant allele was tested for correlation with the clinical presentation, type of @entity102 , hemoglobin level, white blood cell and platelet counts, spleen size, and/or @entity65 . RealTime-PCR was used for amplification of DNA from marrow or peripheral blood. Polycythemia vera was more frequently diagnosed among @entity1 with >or=50% mutational load than among those with <50% mutational load (71% vs 25%; p = 0.003). @entity1 with >or=50% mutational load had higher mean white blood cell count (18.6 billion/L vs 11.3 billion/L; p = 0.043). @entity4407 @entity1 were more likely to have <50% mutational load (48% vs 7%; p = 0.005). @entity381 was more frequent in @entity1 with >or=50% mutational load independent of the diagnosis (89% vs 48%; p = 0.03). @entity65 were reported in 50% of @entity1 with >or=50% mutational load vs 21% of @entity1 with <50% mutational load. @entity4016 quantitation was highest in @entity6582 vera followed by @entity102 , unclassifiable, and essential @entity1148 @entity1 . @entity4016 quantitation appears important in clinical evaluation. Mutational load appears to be helpful in stratification of @entity1 into subgroups with different frequency of complications. Quantitation of @entity4016 mutational load may be useful in evaluating response to therapy.

title: Correlation of @entity4016 @entity4017 mutant allele quantitation with clinical presentation and type of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocythemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['chronic myeloproliferative neoplasms']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic myeloproliferative disease']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['Splenomegaly']

entities_list: @entity4407 :: ('MESH:D013920', 'Disease') :: ['Essential thrombocythemia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular complications', 'cardiovascular complications']

answer: @entity5 :: (MESH:D009369,Disease) :: ['chronic myeloproliferative neoplasm']


abstract: OBJECTIVE: To investigate the impact of selective fetoscopic laser photocoagulation (SFLP) on pre-existing @entity338 in the recipient twin in @entity14244 ( @entity14244 ). METHODS: We evaluated preoperative echocardiograms of all pregnancies with @entity14244 treated with SFLP at our institution from 2001 to 2009 (n = 76). Sixteen (21%) recipients had an @entity358 ( @entity850 / @entity1141 , insufficiency or functional @entity1146 ) before SFLP. Postoperative echocardiograms and medical records from these 16 recipients were reviewed. Changes in pulmonary valve structure and function, and overall cardiac function, were noted after SFLP. RESULTS: The mean gestational age at SFLP was 21 (range, 18.7-24.3) weeks. Seven of sixteen (44%) recipients with @entity358 prior to SFLP survived. Six of the 16 (37.5%) recipient twins had documented absence of persistent @entity358 at birth or at autopsy. Two (12.5%) of the 16 recipients (2.6% of the original cohort) had persistent @entity358 at birth, requiring intervention. Systolic and diastolic function improved or normalized after SFLP in all @entity1 undergoing longitudinal follow-up. There was a tendency for a better cardiovascular profile score (best = 10 points) at initial evaluation in pregnancies with survivors compared with those with no survivors (mean (SD): 5.6 (2.2) vs. 6.75 (1.28)), but this was not statistically significant. Severity of @entity299 did not predict persistence of valve pathology or survival. CONCLUSIONS: SFLP can improve flow through the pulmonary valve of the recipient twin in @entity14244 , probably as a consequence of improvements in right ventricular systolic and diastolic function. However, @entity338 may persist and require postnatal intervention.

title: Effect of selective fetoscopic laser photocoagulation therapy for @entity14244 on XXXX in recipient twins.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['pulmonary valve pathology']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary valve abnormalities', 'abnormal pulmonary valve']

entities_list: @entity14244 :: ('MESH:D005330', 'Disease') :: ['twin-twin transfusion syndrome', 'TTTS']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac involvement']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity338 :: (MESH:D011665,Disease) :: ['pulmonary valve pathology']


abstract: PURPOSE: To assess the feasibility of a conically shaped biodegradable @entity2636 (PU) foam for closure of oroantral communications (OACs). @entity1 AND METHODS: In 10 consecutive @entity1 , fresh OACs (present for <24 hours) were closed with PU foam. Standardized evaluations were performed at 2 and 8 weeks after closure of the OAC. Success was considered permanent closure of the OAC. RESULTS: No complications were observed in 7 of the 10 @entity1 . Of the other 3 @entity1 , 1 developed a maxillary sinusitis that was successfully managed with antibiotics and the OAC recurred in 2 @entity1 . CONCLUSIONS: Permanent closure of the OAC using PU foam was accomplished in 8 of 10 @entity1 . The results obtained in the present study were more favorable than in a previous feasibility study. Therefore, the alterations in the treatment protocol were maintained for additional research of this new and straightforward treatment strategy. In general, closure of OACs with biodegradable PU foam is feasible and has the potential to make surgical treatment unnecessary for a large number of @entity1 with OACs.

title: Feasibility of conical biodegradable XXXX foam for closure of oroantral communications.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane']

answer: @entity2636 :: (MESH:D011140,Chemical) :: ['polyurethane']


abstract: BACKGROUND: @entity263 is the single most prevalent @entity5 in US @entity1 whose gold standard of diagnosis is histologic assessment of biopsies. Manual assessment of stained tissue of all biopsies limits speed and accuracy in clinical practice and research of @entity263 diagnosis. We sought to develop a fully-automated multimodal microscopy method to distinguish cancerous from non-cancerous tissue samples. METHODS: We recorded chemical data from an unstained @entity3145 ( @entity3145 ) using Fourier transform infrared (FT-IR) spectroscopic imaging. Using pattern recognition, we identified epithelial cells without user input. We fused the cell type information with the corresponding stained images commonly used in clinical practice. Extracted morphological features, optimized by two-stage feature selection method using a minimum-redundancy-maximal-relevance (mRMR) criterion and sequential floating forward selection (SFFS), were applied to classify tissue samples as @entity5 . RESULTS: We achieved high accuracy (area under ROC curve (AUC) >0.97) in cross-validations on each of two data sets that were stained under different conditions. When the classifier was trained on one data set and tested on the other data set, an AUC value of ~0.95 was observed. In the absence of IR data, the performance of the same classification system dropped for both data sets and between data sets. CONCLUSIONS: We were able to achieve very effective fusion of the information from two different images that provide very different types of data with different characteristics. The method is entirely transparent to a user and does not involve any adjustment or decision-making based on spectral data. By combining the IR and optical data, we achieved high accurate classification.

title: Multimodal microscopy for automated histologic analysis of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer or non-cancer', 'cancer']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate cancer']

entities_list: @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue microarray', 'TMA']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: Minimized extracorporeal circulation systems in coronary artery bypass may have less impairing effect on hematological parameters and @entity548 compared to conventional systems. The aim of this study was to investigate whether the use of mini systems does result in an increased @entity86 status. METHODS: @entity1 with increased risk of postoperative blood transfusion were randomly allocated to coronary bypass surgery using conventional or minimized extracorporeal circulation. Serial thrombelastographic analysis was performed preoperatively, at day 1 and 5. RESULTS: Forty-six @entity1 were included. In 56% of the @entity1 in the experimental and in 62% in the control group an activated coagulation system, measured as maximal amplitude above normal reference was found preoperatively. This was normalized the day after operation. At day 5 a significant number of @entity1 in the experimental group (p = 0.03) overshooted the preoperative maximal clot strength compared to the control group (p = 0.15); however, a direct intergroup analysis showed no difference. In both groups, hemoglobin levels and platelet counts decreased at day one after surgery. At day 5, hemoglobin was partly and platelets completely normalized. No differences were found with respect to transfusion needs. CONCLUSION: Mini systems seem to induce at least an equal increased state of @entity49 after coronary surgery. No clinical relevant differences could be demonstrated. This could indicate that @entity1 after using mini systems are not protected against a postoperative state of @entity49 .

title: Equally XXXX irrespective of using minimized or conventional ECC systems.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['hypercoagulability', 'increased hypercoagulability']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative hypercoagulative']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity49 :: (MESH:D019851,Disease) :: ['increased hypercoagulability']


abstract: The anterior pituitary gland plays an important role in the regulation of many physiological processes. Formation of @entity976 ( @entity976 ), the precursor of the anterior pituitary, involves evagination of the oral ectoderm in a multi-step process regulated by cell interactions, signaling pathways, and transcription factors. @entity1573 are an excellent model to study development because of the availability of large sample sizes, accurate timing of development, and embryo accessibility. The aim of this study was to quantify mRNA expression patterns in the developing @entity1573 anterior pituitary to evaluate the @entity1573 embryo as a model for @entity1 pituitary development. The expression profiles of 16 genes differentially expressed in @entity976 and neuroectoderm were determined in this study. Among these, @entity17186 , @entity17187 , and @entity17188 mRNA levels were high on embryonic days (e) 2.5 to e3 in @entity976 and decreased during development. Expression of @entity17189 and @entity17190 mRNA in @entity976 reached the highest levels by e7 and e6.5, respectively. Levels of glycoprotein subunit a mRNA increased beginning at e4. @entity17191 mRNA showed the highest expression at e3 to e3.5 in neuroectoderm. @entity17192 showed slight decreases in mRNA expression in both tissues during development, while @entity17193 and @entity17194 mRNA expression increased in later development. Taken together, we present the first quantitative transcriptional profile of pituitary organogenesis. Our results will help further understanding of the functional development of this gland. Moreover, because of the high similarity in gene expression patterns observed between @entity1573 and @entity19 , @entity1573 could serve as an excellent model to study genetic and molecular mechanisms underlying pituitary development.

title: Changes in gene expression during pituitary morphogenesis and organogenesis in the XXXX embryo.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity1573 :: ('9031', 'Species') :: ['chickens', 'Chickens', 'chicken']

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['RP', "Rathke's pouch"]

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: The capacity of LM cells to initiate @entity5 formation in vivo was investigated in athymic (nude) BALB/c @entity19 . @entity5 cells inoculated s.c. over the left thighs of @entity19 formed large, grossly visible @entity5 within 2 weeks postinoculation. @entity5 doubling times were slightly longer than doubling times of LM cells in suspension culture. Histological examination of necropsied @entity19 revealed that @entity5 cells were invasive into host tissue and formed numerous bizarre mitotic figures. The @entity5 were classified a @entity1492 -like @entity5 . @entity3 to the lungs was observed in @entity19 inoculated with a variety of @entity5 cells. LM cells cultured in the presence of @entity1877 analogues ( @entity11455 , @entity11456 , or @entity8398 ) had grossly altered membrane lipid compositions. However, all formed @entity5 in the @entity19 with @entity5 volume doubling times similar to that of LM cells grown in choline medium. LM cells grown with 10% calf serum had doubling times about 42% shorter. LM fibroblasts injected into @entity19 provide a model system for investigation of @entity5 biology related to @entity3 formation.

title: Development of XXXX in athymic ( @entity19 from LM cells grown in vitro.

entities_list: @entity8398 :: ('MESH:D019856', 'Chemical') :: ['ethanolamine']

entities_list: @entity11456 :: ('MESH:C017500', 'Chemical') :: ['N-monomethylethanolamine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity11455 :: ('MESH:D003642', 'Chemical') :: ["N,N'-dimethylethanolamine"]

entities_list: @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastatic tumors']


abstract: Persisting or newly developed sequelae of @entity3510 can be encountered after conservative as well as surgical treatment. On the spine it is a deformity, most frequently a pathological @entity1513 , instability or possibly stenosis of the spinal canal. All these factors can evoke @entity158 and lead secondarily to progression of an already present nervous affection or to its late development. In the first place it is necessary to deal in these conditions with the deformity which along with the instability leads to permanent @entity158 . The usual indication for surgery is a pathological @entity1513 of the thoracolumbal transition above 15 degrees, but its tolerance is frequently individual. Late nervous lesions are usually the result of the intra- and extradural development of scars, @entity602 and posttraumatic @entity1644 . Failure of the original treatment is due to incorrect assessment of the @entity130 , inadequate conservative or surgical treatment, incorrect surgical technique and errors as regards the selection of the surgical procedure. Correct assessment of the posttraumatic condition calls for detailed radiodiagnostic assessment. Many @entity85 call for a combined anterior and posterior operation. However, if there is no posterior obstacle for correction it is possible to implement only an anterior operation. Contemporary surgical techniques and implantation systems make short fusion with a minimal functional loss possible. Key words: @entity85 , @entity51 , surgical tactics.

title: [Principles in sequelae of XXXX .].

entities_list: @entity3510 :: ('MESH:D013124', 'Disease') :: ['spinal injuries']

entities_list: @entity1644 :: ('MESH:D013595', 'Disease') :: ['syringomyelia']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord atrophy']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neural deficit']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['posttraumatic deformities', 'posttraumatic deformity']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['type of injury']

answer: @entity3510 :: (MESH:D013124,Disease) :: ['spinal injuries']


abstract: @entity1 requiring creation of an arteriovenous (AV) @entity292 for long-term dialysis access have a high incidence of cardiovascular risk factors, as well as immunosuppression, @entity16 , and @entity1423 related to @entity177 . However, the morbidity and mortality of @entity2548 creation, and the effect of anesthetic technique on outcome, have not been reported. We therefore retrospectively studied all @entity1 (n = 469) having an @entity2548 placed at the Mayo Clinic between 1986 and 1991. Preoperative variables studied were age (mean 63 +/- 14 yr), sex (60% male), @entity6 (26% incidence), @entity101 (92%), the presence of a previous @entity2548 (31%), @entity453 (86%), and previous @entity583 ( @entity583 ) (42%). Outcome variables studied were @entity292 failure prior to first attempted dialysis (8.7% incidence), @entity281 (3.4%), @entity16 (1.9%), @entity410 (0.2%), nonfatal @entity299 ( @entity583 or arrest) (1.5%), and fatal @entity299 (2.1%). Associations of preoperative factors, outcomes, and anesthetic technique were analyzed by analysis of variance and Wilcoxon rank sum analysis for age, and by exact conditional frequency table analysis for all other factors. A previous @entity2548 was associated with @entity281 (P < 0.002) and nonfatal @entity299 (P < 0.003). Increased age (P < 0.025) and previous @entity583 (P < 0.01) were associated with adverse cardiac outcomes. Neither local anesthesia, @entity5300 , nor general anesthesia were significantly associated with an increased frequency of any adverse outcome. The comparison of general with local and brachial plexus anesthetics was limited by low statistical power.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Risk factors in @entity1 having surgery to create an XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet dysfunction']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity5300 :: ('MESH:D020516', 'Disease') :: ['brachial plexus block']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac event', 'cardiac events']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity2548 :: ('MESH:D001164', 'Disease') :: ['AV fistula']

answer: @entity2548 :: (MESH:D001164,Disease) :: ['arteriovenous fistula']


abstract: To form @entity1568 -fixing symbioses, legume plants recognize a bacterial signal, Nod Factor (NF). The legume @entity4166 has two predicted NF receptors that direct separate downstream responses to its symbiont @entity16258 . NOD FACTOR PERCEPTION encodes a putative low-stringency receptor that is responsible for @entity460 spiking and transcriptional responses. LYSIN MOTIF RECEPTOR-LIKE KINASE3 (LYK3) encodes a putative high-stringency receptor that mediates @entity2348 . We localized green fluorescent protein (GFP)-tagged LYK3 in @entity4166 and found that it has a punctate distribution at the cell periphery consistent with a plasma membrane or membrane-tethered vesicle localization. In buffer-treated control roots, LYK3:GFP puncta are dynamic. After inoculation with compatible @entity16258 , LYK3:GFP puncta are relatively stable. We show that increased LYK3:GFP stability depends on bacterial NF and NF structure but that NF is not sufficient for the change in LYK3:GFP dynamics. In uninoculated root hairs, LYK3:GFP has little codistribution with mCherry-tagged FLOTILLIN4 (FLOT4), another punctate plasma membrane-associated protein required for infection. In inoculated root hairs, we observed an increase in FLOT4:mCherry and LYK3:GFP colocalization; both proteins localize to positionally stable puncta. We also demonstrate that the localization of tagged FLOT4 is altered in plants carrying a mutation that inactivates the kinase domain of LYK3. Our work indicates that LYK3 protein localization and dynamics are altered in response to symbiotic bacteria.

title: Symbiotic rhizobia bacteria trigger a change in localization and dynamics of the XXXX receptor kinase LYK3.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity4166 :: ('3880', 'Species') :: ['M. truncatula', 'Medicago truncatula']

entities_list: @entity16258 :: ('382', 'Species') :: ['Sinorhizobium meliloti', 'S. meliloti']

answer: @entity4166 :: (3880,Species) :: ['Medicago truncatula']


abstract: @entity1 peripheral blood monocytes from normal, healthy donors express the @entity1453 , @entity9637 and @entity329 ,95. These heterodimeric antigens are members of a glycoprotein family sharing a common beta subunit but endowed with distinct alpha chains. They have been shown to play an important role in cell-cell interactions. In the present study we have investigated the role of these molecules in the interaction of monocytes with endothelial cells and @entity320 ( @entity5 ) cells. Heterotypic cell-cell interactions were studied in single cell conjugate assays and by adhesion of monocytes to monolayers of cells. The results demonstrate that monoclonal antibodies directed against @entity1453 , @entity9536 , @entity329 ,95 alpha and the common beta chain strongly reduce the number of conjugates (71, 50, 60 and 89% inhibition, respectively), formed between monocytes and @entity320 or endothelial cells in a single cell assay. In contrast, adhesion of monocytes to monolayers of the same cells seems only to depend on @entity329 ,95, since only antibodies directed to the alpha chain of this molecule and to the common beta chain inhibited adhesion. Interestingly, the number of conjugates formed with @entity320 cells in single cell assays was at least twice the number of conjugates formed between monocytes and endothelial cells, whereas no differences were observed in the adhesion of monocytes to monolayers of these cells. However, the basis for this phenomenon is not yet clear. These results indicate that not only @entity1453 but also @entity9637 and @entity329 ,95 can mediate adhesion to target cells in suspension, but that monocyte adhesion to monolayers is caused by a different mechanism in which the @entity329 ,95 molecule seems to play a prominent role.

title: Differential function of XXXX family molecules (CD11 and CD18) in adhesion of @entity1 monocytes to @entity320 and endothelial cells.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1453 :: ('3683', 'Gene') :: ['LFA-1', 'leucocyte function-associated antigen (LFA)-1', 'LFA-1 alpha']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity1453 :: (3683,Gene) :: ['LFA-1']


abstract: BACKGROUND AND PURPOSE: Large admission @entity75 volumes are associated with poor outcomes despite @entity64 treatment. The primary aims of our study were to determine whether CTA collaterals correlate with admission @entity75 volumes in @entity1 with @entity1984 with proximal occlusions, and whether a CTA collateral profile could identify large DWI volumes with high specificity. MATERIALS AND METHODS: We studied 197 @entity1 with @entity1984 with M1 and/or @entity432 . We segmented admission and follow-up @entity75 volumes, and categorized CTA collaterals by using a 5-point CS system. ROC analysis was used to determine CS accuracy in predicting @entity75 volumes >100 mL. @entity1 were dichotomized into 2 categories: CS = 0 (malignant profile) or CS>0. Univariate and multivariate analyses were performed to compare imaging and clinical variables between these 2 groups. RESULTS: There was a negative correlation between CS and admission @entity75 volume (   = -0.54, P < .0001). ROC analysis revealed that CTA CS was a good discriminator of @entity75 volume >100 mL (AUC = 0.84, P < .001). CS = 0 had 97.6% specificity and 54.5% sensitivity for DWI volume >100 mL. CS = 0 @entity1 had larger mean admission DWI volumes (165.8 mL versus 32.7 mL, P < .001), higher median NIHSS scores (21 versus 15, P < .001), and were more likely to become functionally dependent at 3 months (95.5% versus 64.0%, P = .003). Admission NIHSS score was the only independent predictor of a malignant CS (P = .007). CONCLUSIONS: In @entity1 with @entity1984 with PAOs, CTA collaterals correlate with admission DWI infarct size. A malignant collateral profile is highly specific for large admission @entity75 size and poor functional outcome.

title: Malignant CTA collateral profile is highly specific for large admission DWI infarct core and poor outcome in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['acute stroke']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['DWI lesion']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['intracranial ICA occlusions']

answer: @entity64 :: (MESH:D020521,Disease) :: ['acute stroke']


abstract: An inhibitor of pancreatic elastase (EI), which can also inhibit chymotrypsin, and an inhibitor of trypsin (TI), which can also inhibit @entity19361 , have been isolated from @entity291 plasma. EI and TI belong to the serpin family of inhibitors. The size of both inhibitors is approx. 60 kDa and they are able to form @entity214 -stable complexes with proteinases. Curiously, TI dimerizes in the presence of @entity214 , a feature which has been observed previously only in non-denaturing gels of @entity1 alpha 1-antitrypsin (alpha 1PI). EI and TI are glycosylated [16% and 19% (w/w) respectively] and their @entity535 compositions are similar to those of other plasma serpins. Neither EI nor TI is the equivalent of @entity291 alpha 1PI, as revealed by partial sequence analysis of their N-termini and reactive sites. Rather, both inhibitors appear to be related to @entity1 @entity8698 . Inhibition of pancreatic elastase and chymotrypsin by EI occurs with a kass. approximately 10(5) M-1.s-1. TI inhibits trypsin with a kass. approximately 10(5) M-1.s-1. @entity19361 is inhibited by TI with a kass. approximately 10(3) M-1.s-1. The values of the kinetic constants are similar to those determined for the well-studied human serpins. Antibodies to EI and TI reveal a set of four antigenically related proteins of similar size in plasma. In addition, they detect the same set of proteins in milk. The inhibitors isolated from milk are identical to EI and TI from plasma. EI could control the activity of chymotrypsin-like proteinases in milk. In contrast, no target proteinases of TI in milk can be suggested.

title: Characterization of two serpins from XXXX plasma and milk.

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity8698 :: ('12', 'Gene') :: ['alpha 1-antichymotrypsin']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: BACKGROUND AND PURPOSE: Initial reports of stent-assisted angioplasty for @entity4522 suggest this is a feasible treatment, but there have been little data regarding predictors of success or failure. We analyzed a series of @entity1 for independent predictors of neurologic morbidity and mortality. METHODS: @entity1 charts and angiograms from 39 @entity1 who underwent intracranial angioplasty and stent placement of vertebrobasilar stenoses were retrospectively reviewed to obtain clinical and detailed angiographic data on potential predictors of neurologic morbidity and mortality. Univariate analyses of these predictors were performed with either Fisher's exact test or simple logistic regression. Multivariate analysis was subsequently performed on the statistically significant predictors. RESULTS: Complete clinical data were obtained for 39 @entity1 , and angiographic review was possible for 35 of them. Angiography revealed severe intracranial vertebral (n = 18), basilar (n = 15), or basilar and vertebral (n = 2) stenoses. Two @entity1 (5.1%) died in the periprocedural period, nine @entity1 (23.1%) had @entity16 , and one @entity1 (2.6%) had transient neurologic symptoms. Univariate analysis revealed female sex, @entity6 , and failure of @entity1229 or heparin therapy were associated with neurologic morbidity, whereas female sex, Mori B lesion, and length-to-stenosis ratio were associated with mortality. The presence of @entity6 was the only independent predictor of neurologic morbidity and mortality. CONCLUSION: Because of the limited number of @entity1 available for analysis, the only independent predictor of neurologic morbidity and mortality was @entity6 , but several other predictors showed trends that deserve further review in future series.

title: Stent-assisted angioplasty of XXXX : midterm analysis of clinical and radiologic predictors of @entity16 and mortality.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic complications']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['coumadin']

entities_list: @entity4522 :: ('MESH:D002537', 'Disease') :: ['intracranial vertebrobasilar atherosclerosis']

answer: @entity4522 :: (MESH:D002537,Disease) :: ['intracranial vertebrobasilar atherosclerosis']


abstract: BACKGROUND AND OBJECTIVE: Adults with primary refractory or relapsed @entity981 ( @entity981 ) have a very poor prognosis with current salvage chemotherapies. Complete remissions (CR) can be obtained with intensive regimens in 40-60% of cases, but they are short-lived. In an effort to obtain high CR rates and prolong their duration and achieve long-term survival in a substantial number of @entity1 , we designed an intensive combination salvage regimen (RELAL-88). In this protocol, chemotherapy was to be followed by an allogeneic or autologous @entity8 ( @entity8 ) within three months from CR. DESIGN AND METHODS: Forty-five @entity1 with primary refractory (n=17) or first relapsed @entity981 (n=28) were treated with the RELAL-88 five-day induction regimen comprising @entity7324 , @entity2664 , @entity786 , intermediate-dose @entity2592 , @entity617 and @entity1499 . Twenty-eight @entity1 received @entity1261 ( @entity1261 ), 16 @entity1 from day 6 (early @entity1261 group) and 12 from day 14 of therapy (delayed @entity1261 group). RESULTS: Thirty-four @entity1 (74%) achieved CR (95% CI 60-87), two died in aplasia due to @entity281 and nine were non-responders. No pretreatment variable analyzed was predictive of the chance of obtaining CR. Recovery of neutrophils occurred at a median of 29 days from the start of chemotherapy without @entity1261 and 20 days with @entity1261 (p = 0.005), without differences between the early and late @entity1261 groups. Non-hematologic side effects were usually well tolerated and consisted mainly of @entity281 and @entity33 . Twenty-three of 34 @entity1 (68%) who achieved CR reached the planned @entity8 (nine autologous and 14 allogeneic). The median overall survival was 5.7 months, and the median disease-free survival for those achieving CR was 4.6 months. Of the variables analyzed for their influence on overall survival among the 34 @entity1 who achieved CR, only the availability of an HLA-compatible sibling was associated with a prolonged survival (p = 0.03). INTERPRETATION AND CONCLUSIONS: The RELAL-88 intensive salvage regimen produces a very high rate of CR in poor-risk adult @entity981 . @entity1503 were tolerable, and most eligible @entity1 could undergo the planned @entity8 . @entity1261 significantly shortened the period of @entity1398 by about eight days, irrespective of whether it was started early or late after chemotherapy. However, as with other currently available salvage therapies, remissions were short-lived, and more effective post-remission treatment strategies are needed. In our experience, only allogeneic @entity8 offered the chance of long-term survival.

title: Intensive salvage chemotherapy for primary refractory or first relapsed adult XXXX : results of a prospective trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplant']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia']

entities_list: @entity7324 :: ('MESH:D014751', 'Chemical') :: ['vindesine']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor']

entities_list: @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Non-hematologic toxicities']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']


abstract: BACKGROUND: Cutaneous extranodal NK/ @entity784 , nasal type (NK/T) is relatively rare, associated with @entity146 and poor prognosis. Histopathological findings, immunohistochemical study and EBV-encoded RNA (EBER) in situ hybridization are essential for the diagnosis. CASE REPORT: A 54-year-old Thai @entity1 with NK/T of the nasal cavity initially presented with cutaneous NK/T mimicking @entity738 . The skin biopsies were performed twice due to the marked @entity39 in the first one. The second biopsy revealed small, medium, and large atypical lymphoid cells infiltrating fat lobules with @entity39 foci and granulomatous reaction. Within the @entity32 , the atypical lymphoid cells showing involvement of the blood vessel (angiocentricity) were noted. Immunostaining demonstrated that the atypical lymphoid cells marked with CD3, @entity2940 , and @entity13433 , but they did not mark with @entity5893 , @entity2225 , @entity5824 , or @entity5823 . EBER in situ hybridization was positive. CONCLUSION: Cutaneous NK/T can produce @entity738 . The recognition of atypical lymphoid cells showing angiocentricity together with immunohistochemistry and EBER in situ hybridization are crucial for the correct diagnosis.

title: Extranodal NK/T cell lymphoma, nasal type, presenting with primary cutaneous lesion mimicking XXXX : a case report and review of literature.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['granulomatous inflammation']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous panniculitis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma']

answer: @entity738 :: (MESH:D006099,Disease) :: ['granulomatous panniculitis']


abstract: The use of @entity618 ( @entity2098 ) in @entity1 with @entity3441 ( @entity3441 ) is increasing. However, the clinical benefit of its monitoring has been scarcely studied, and little is known about its pharmacokinetics in this context. The objectives of the present study were: (i) to study and model the pharmacokinetics of @entity3442 ( @entity3443 ; the active moiety of @entity2098 ) in paediatric @entity1 with @entity3441 given @entity2098 , at all stages of the disease; (ii) to develop a Bayesian estimator (MAP-BE) for individual inter-dose area under the concentration-time curve (AUC) prediction in this population, using a limited blood sampling strategy (LSS). Full-pharmacokinetic (PK) profiles of @entity3443 collected in paediatric inpatients with @entity3441 already treated with a maintenance immunosuppressive therapy based on @entity2098 (with no calcineurin inhibitors; CNI) were studied. A classical iterative two-stage (ITS) method was applied to model the data and develop MAP-BEs using a one-compartment open model where the absorption is described by a double gamma law allowing the description of a potential enterohepatic recirculation. The performance of the MAP-BE developed for individual exposure assessment was evaluated by the bias and precision of predicted AUCs with respect to measured, trapezoidal AUCs (reference value), and by the proportion of predicted AUCs with absolute error >20%. These PK tools were tested in an independent group of @entity1 . Sixty PK profiles of @entity3443 from @entity1 receiving @entity2098 in association to @entity288 or given alone were included in the study. Forty-five of these PK profiles were used to develop a PK model and a MAP-BE, and 15 for their validation. In the building group, the PK model fitted accurately the PK profiles of @entity3443 : mean residual error of modelled vs. reference AUC was m  SD=-0.015  0.092 (range: -0.153 to 0.204). The MAP-BE which allowed the estimation of @entity3443 AUC on the basis of a 20 min-60 min-180 min LSS was then developed. In the independent group of @entity1 , its mean residual error vs. reference AUCs was m  SD=-0.036  0.145 (range: -0.205 to 0.189). Thus, a PK model and its derived MAP-BE for @entity2098 (without any associated CNI) when given to @entity1 with @entity3441 have been developed. Clinical trials using these PK tools could test the potential impact of the therapeutic drug monitoring of @entity2098 based on the AUC on the clinical evolution of @entity3441 .

title: Development of a Bayesian estimator for the therapeutic drug monitoring of XXXX in @entity1 with @entity3441 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity3441 :: ('MESH:C535761', 'Disease') :: ['INS', 'idiopathic nephrotic syndrome']

entities_list: @entity3442 :: ('MESH:D009173', 'Chemical') :: ['mycophenolic acid']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity618 :: (MESH:C063008,Chemical) :: ['mycophenolate mofetil']


abstract: During the 3-year study period, 155 culture-positive cases of @entity7394 were reviewed at the Institute of @entity1 Health, Kabul. They comprised 0.6% of hospital admissions due to medical disorders in our institute. About 80% of @entity1 belonged to an age group of 1-10 years and only two @entity1 were less than 1 year old. The male to female ratio was 1.3:1. There was no history of previous vaccination against @entity7394 in 96.7% of @entity1 . In the majority of @entity1 @entity7394 was diagnosed (77.4%), followed by laryngeal (16.1%) an combined pharyngolaryngeal (6.5%). Clinical presentation was with a mild to moderate degree of @entity221 , sore throat, @entity3799 , toxaemia, @entity591 and a characteristic thick greyish-white membrane. The main early complications were @entity3885 (35), @entity2401 (18), shock (3), @entity5013 (3) and @entity177 (2). The overall case fatality rate was 19.3%. Prognosis was unfavourable in @entity1 with @entity7394 when there was a delay of more than 4 days before reaching the hospital and if there was a delay in relieving @entity3885 by tracheostomy. Outcome was unrelated to the age of the @entity1 .

title: XXXX in Afghanistan--review of 155 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients', 'patient']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['laryngeal obstruction']

entities_list: @entity7394 :: ('MESH:D004165', 'Disease') :: ['diphtheria', 'laryngeal diphtheria', 'faucial diphtheria']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['cervical lymphadenopathy']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis']

entities_list: @entity5013 :: ('MESH:D009443', 'Disease') :: ['polyneuritis']

answer: @entity7394 :: (MESH:D004165,Disease) :: ['Diphtheria']


abstract: Significant @entity3883 in @entity1689 is generally considered to be rare. Eleven of 57 consecutive @entity1 with proven @entity1689 have developed @entity3883 of more than transient duration. Eight presented as @entity1087 complicating known @entity788 and three as @entity1087 of unknown cause. Life table analysis showed a steady rise in the risk of developing @entity1087 up to the end of 10 years from the onset of @entity1689 . @entity1087 was found to occur in the presence of more "destructive" disease, and @entity1087 @entity1 had a higher incidence of @entity16581 , @entity6 at the time of presentation with @entity1087 . @entity3883 caused by @entity1689 was found to carry a good prognosis for @entity1087 , for @entity158 and for life. Only one of the 11 @entity1 died in hospital. It is important to distinguish @entity1689 from @entity5 in these @entity1 . Pre-operative and intra-operative cytology have been helpful. Stent insertion is not an appropriate method of treatment for these @entity1 because of the benign nature of the disease and the possibility of exacerbating the @entity788 . It is important to be aware of another form of "malignant masquerade" causing @entity3883 .

title: XXXX in @entity1689 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3883 :: ('MESH:D041781', 'Disease') :: ['Obstructive jaundice', 'significant obstructive jaundice', 'obstructive jaundice']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice', 'jaundiced', 'Jaundice']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes and malabsorption']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1689 :: ('MESH:D050500', 'Disease') :: ['chronic pancreatitis']

entities_list: @entity16581 :: ('MESH:C566837', 'Disease') :: ['pancreatic calcification']

answer: @entity3883 :: (MESH:D041781,Disease) :: ['Obstructive jaundice']


abstract: BACKGROUND: Performing endoscopic submucosal dissection (ESD) by using standard endoscopy platforms is technically challenging because of the equipment's lack of dexterity. OBJECTIVE: To explore the feasibility of using the Master and Slave Transluminal Endoscopic Robot (MASTER), a novel robotics-enhanced endosurgical system, to perform ESD. DESIGN: ESD was performed on simulated @entity1819 in 5 Erlangen porcine stomach models (ex vivo) and 5 live @entity1707 (in vivo). Performance of ESD by using the MASTER was compared with that using the insulation-tipped (IT) diathermic knife. SETTING: SMART Laboratory, Advance Surgical Training Centre, National University Hospital, Singapore. SUBJECTS: Five Erlangen porcine stomach models and 5 @entity1707 , 5 to 7 months old, each weighing about 35 kg. INTERVENTIONS: ESD. MAIN OUTCOME MEASUREMENTS: Lesion resection time, grasper and hook efficacy grade, completeness of resection, and presence of procedure-related perforation. RESULTS: In the Erlangen stomach models, 15 simulated lesions from the @entity418 , antrum, and body were removed en bloc (mean dimension, 37.4 x 26.5 mm) by electrocautery excision using the MASTER. The mean ESD time was 23.9 minutes (range 7-48 minutes). There was no difference in the dissection times of lesions at different locations (P = .449). In the live @entity1707 , the MASTER took a mean of 16.2 minutes (range 3-29 minutes) to complete the ESD of 5 @entity1819 , whereas the IT diathermic knife took 18.6 minutes (range 9-34 minutes). There was no significant difference in the times taken (P = .708). All lesions were excised en bloc; the mean dimensions of lesions resected by the MASTER and the IT diathermic knife were 37.2 x 30.1 mm and 32.78 x 25.6 mm, respectively. The MASTER exhibited good grasping and cutting efficiency throughout. Surgical maneuvers were achieved with ease and precision. There was no incidence of excessive @entity548 or stomach wall perforation. LIMITATIONS: Exploratory study with limited sample size. CONCLUSIONS: Performing ESD by using the MASTER is feasible.

title: Endoscopic submucosal dissection of XXXX by using a Master and Slave Transluminal Endoscopic Robot (MASTER).

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesions']

answer: @entity1819 :: (MESH:D013272,Disease) :: ['gastric lesions']


abstract: BACKGROUND: The incidence and management of @entity1095 of @entity1580 is unsettled. @entity1 AND METHODS: @entity1095 of spontaneous @entity1580 were examined in a 5-year retrospective review. @entity1 who had @entity1095 were categorized as group A; those without as group B. RESULTS: Thirty-eight major vessels were affected in 18 @entity1 . No @entity1 underwent a peripheral vascular procedure for complications of the carotid, subclavian, celiac, mesenteric, or renal arteries. Three @entity1 underwent femorofemoral bypass for acute @entity432 due to dissection. A fourth @entity1 had repair of an @entity1029 that developed as a complication of chronic dissection. The mortality rate was 17% for group A, 9% for group B, and 10% overall. Following repair of the @entity1580 , the majority of the @entity1095 resolved. CONCLUSIONS: Peripheral revascularization is infrequently required in @entity1580 following primary dissection repair.

title: XXXX of @entity1580 .

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular complications', 'Peripheral vascular complications']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['iliofemoral occlusion']

entities_list: @entity1029 :: ('MESH:D017543', 'Disease') :: ['iliac aneurysm']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

answer: @entity1095 :: (MESH:D016491,Disease) :: ['Peripheral vascular complications']


abstract: The histopathologic grading of @entity10915 is a subjective process. In this study, automated image analysis using knowledge-guided software was used to quantitatively assess colorectal glandular characteristics. Cases of histologically normal mucosa and of low, moderate and high grade @entity1141 were examined using the technique. A total of 19 morphometric and densitometric features were measured on each gland. These included gland shape, epithelial area, nuclear stratification and nuclear optical density. Discriminant analysis of the data revealed those morphometric features which provided the best discrimination between the various histologic groups. The area of epithelium occupied by nuclei was the strongest discriminating variable, and this, in combination with a discriminant function derived from the remaining variables, was used to plot cases in bivariate sample space. The plots revealed that the data for normal glands were consistently well separated from @entity6349 gland data. Data sets belonging to the various grades of @entity1141 showed varying degrees of separation, depending which two histologic groups the discriminant function was based on. This study showed that automated image analysis of complex histologic scenes is possible using knowledge-guided segmentation and that it can provide useful data for the objective classification of @entity14 .

title: Knowledge-guided segmentation and morphometric analysis of XXXX .

entities_list: @entity10915 :: ('MESH:C563924', 'Disease') :: ['colorectal adenomatous dysplasia']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal dysplasia']

entities_list: @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal dysplasia']