abstract: @entity2 is the leading cause of @entity5 deaths worldwide. Clinical staging classification is generally insufficient to provide a reliable prognosis, particularly for early stages. In addition, prognostic factors are therefore needed to better forecast life expectancy and optimize adjuvant therapeutic strategy. Recent evidence indicates that alterations of the DNA replication program contribute to @entity5 from its early stages and that @entity5 cells are frequently exposed to endogenous replication stress. We therefore hypothesized that genes involved in the replication stress response may represent an under-explored source of biomarkers. Expressions of 77 DNA replication-associated genes implicated in different aspects of chromosomal DNA replication, including licensing, firing of origins, elongation, replication fork maintenance and recovery, lesion bypass and post-replicative repair were determined in primary @entity5 and adjacent normal tissues from 93 @entity1 suffering from early- or mid-stage @entity1149 ( @entity1149 ). We then investigated a statistically significant interaction between gene expressions and survival of early-stage @entity1149 @entity1 .The expression of five genes, that is, @entity40112 , @entity9370 , @entity6545 , @entity40113 and @entity22733 was associated with overall, disease-free and relapse-free survival. The expression levels are independent of treatment and stage classification. Except @entity6545 , their prognostic role on survival persists after adjustment on age, sex, treatment, stage classification and conventional proliferation markers, with a hazard ratio of 36.3 for @entity40112 (95%CI 2.6-517.4, P=0.008), 23.5 for @entity9370 (95%CI 1.9-288.4, P=0.01), 20.7 for @entity40113 (95%CI 1.5-275.9, P=0.02) and 18.5 for @entity22733 (95%CI 1.3-267.4, P=0.03). We also show that a five-gene signature including @entity40112 , @entity9370 , @entity6545 , @entity40113 and @entity22733 separates @entity1 into low- and high-risk groups, with a hazard ratio of 14.3 (95% CI 5.1-40.3, P<0.001). This 'replication stress' metamarker may be a reliable predictor of survival for @entity1149 , and may also help understand the molecular mechanisms underlying @entity5 progression.

title: DNA replication stress response involving @entity9370 , @entity22733 , @entity40112 , XXXX and @entity40113 upregulation prognoses the outcome of early/mid-stage @entity1149 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'neoplasia', 'tumors']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

answer: @entity6545 :: (5888,Gene) :: ['RAD51']


abstract: The southern state of Kerala, India was seriously affected by a @entity12517 in 2007. As this outbreak was the first of its kind, the morbidity incurred by the epidemic was a challenge to the state's public health system. A cross sectional survey was conducted in five districts of Kerala that were seriously affected by the epidemic, using a two-stage cluster sampling technique to select households, and the @entity1 were identified using a syndromic case definition. We calculated the direct health expenditure of families and checked whether it exceed the margins of @entity16839 ( @entity16839 ). The median (IQR) total out-of-pocket (OOP) health expenditure in the study population was USD7.4 (16.7). The OOP health expenditure did not show any significant association with increasing per-capita monthly income.The major share (47.4%) of the costs was utilized for buying medicines, but costs for transportation (17.2%), consultations (16.6%), and diagnoses (9.9%) also contributed significantly to the total OOP health expenditure. The OOP health expenditure was high in private sector facilities, especially in tertiary care hospitals. For more than 15% of the respondents, the OOP was more than double their average monthly family income. The @entity12517 outbreak of 2007 had significantly contributed to the OOP expenditure of the affected community in Kerala.The OOP health expenditure incurred was high, irrespective of the level of income. Governments should attempt to ensure comprehensive financial protection by covering the costs of care, along with loss of productivity.

title: Economic impact of XXXX : out-of-pocket health expenditures during the 2007 outbreak in Kerala, India.

entities_list: @entity12517 :: ('MESH:D065632', 'Disease') :: ['chikungunya', 'chikungunya epidemic']

entities_list: @entity16839 :: ('MESH:D002388', 'Disease') :: ['catastrophic health expenditure', 'CHE']

answer: @entity12517 :: (MESH:D065632,Disease) :: ['chikungunya epidemic']


abstract: A 79-year-old @entity1 , who had had no history of @entity130 , @entity378 , or @entity1413 , was referred for examination of general fatigue and @entity851 of breath on exertion. Physical examination revealed engorged neck veins, @entity382 , and @entity843 with abdominal distention. On chest x-ray the cardiac shadow was slightly enlarged and bilateral @entity1143 was present. An electrocardiogram showed low voltage of the QRS complex. Computed tomographic scans revealed two lumens in the remarkably dilated ascending aorta and the severely thickened pericardium. Cardiac catheterization showed elevated right atrial pressure and elevated right and @entity1002 , in addition to a pressure record of early diastolic dip and end-systolic plateau in the right ventricle. Aortography demonstrated @entity1580 localized to the ascending aorta. On the basis of these findings, the diagnosis of chronic ascending @entity1580 complicated with @entity3822 was made. After subtotal pericardiectomy, graft replacement of the ascending aorta and proximal aortic arch was performed with successful results. Her postoperative recovery was uneventful. Histological studies of the pericardium showed @entity82 and marked infiltration of the inflammatory cells. No findings of specific @entity2396 such as @entity378 or @entity1413 were detected.

title: @entity3822 following hemopericardium due to ascending XXXX : A case report.

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['shortness']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular end-diastolic pressures']

entities_list: @entity3822 :: ('MESH:D010494', 'Disease') :: ['constrictive pericarditis']

entities_list: @entity2396 :: ('MESH:D010493', 'Disease') :: ['pericarditis']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

entities_list: @entity382 :: ('MESH:D006529', 'Disease') :: ['hepatomegaly']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity1413 :: ('MESH:D003095', 'Disease') :: ['collagen diseases']

answer: @entity1580 :: (MESH:C562834,Disease) :: ['aortic dissection']


abstract: BACKGROUND: Autologous cord blood (CB) red blood cells (RBCs) can partly substitute transfusion needs in premature @entity1 suffering from @entity417 . To explore whether expanded CB cells could provide additional autologous cells suitable for transfusion, we set up a simple one-step protocol to expand premature CB cells. STUDY DESIGN AND METHODS: CB buffy coat cells and isolated @entity2280 -positive ( @entity2280 (pos) ) cells from premature and full-term CB and adult blood were tested with several combinations of growth factors while omitting xenogeneic proteins from the culture medium. Cell differentiation was analyzed serially during 21 days using flow cytometry, progenitor assays, and high-performance liquid chromatography. RESULTS: Expanded CB buffy coat cells resulted in a threefold higher number of erythroblasts than the isolated @entity2280 (pos) cells. However, the RBCs contaminating the buffy coat remained present during the culture with uncertain quality. Premature and full-term CB @entity2280 (pos) cells had similar fold expansion capacity and erythroid differentiation. With the use of @entity2772 , @entity6826 , and @entity1307 , the fold increases of all @entity2280 (pos) cell sources were similar: CB 3942    1554, adult peripheral mobilized blood 4702    1826, and bone marrow (BM) 4143    1908. The proportion of @entity33009 expression indicating erythroblast presence on Day 21 was slightly higher in the adult @entity2280 (pos) cell sources: peripheral blood stem cells (96.7    0.8%) and BM (98.9    0.5%) compared to CB (87.7    2.7%; p = 0.002). We were not able to induce further erythroid maturation in vitro. CONCLUSION: This explorative study showed that fairly pure autologous erythroid-expanded cell populations could be obtained by a simple culture method, which should be optimized. Future challenges comprise obtaining ex vivo enucleation of RBCs with the use of a minimal manipulating approach, which can add up to autologous RBCs derived from CB in the treatment of @entity417 of @entity3465 .

title: Exploring the use of expanded erythroid cells for autologous transfusion for XXXX of @entity3465 .

entities_list: @entity6826 :: ('4254', 'Gene') :: ['stem cell factor']

entities_list: @entity3465 :: ('MESH:C536271', 'Disease') :: ['prematurity']

entities_list: @entity1307 :: ('2056', 'Gene') :: ['erythropoietin']

answer: @entity417 :: (MESH:D000740,Disease) :: ['anemia']


abstract: BACKGROUND: The presence or absence of lymph node @entity3 is known to be an important prognostic factor for @entity1 with @entity788 . Few studies have investigated the ratio of the number of lymph nodes harboring @entity5 to the total number of lymph nodes examined (lymph node ratio [LNR]) with regard to outcome after pancreaticoduodenectomy for @entity788 . METHODS: Between 1995 and 2005, a total of 905 @entity1 underwent pancreaticoduodenectomy for @entity788 . Demographics, operative data, number of lymph nodes evaluated, number of lymph nodes with @entity189 , LNR, pathologic margin status, and long-term survival were analyzed. RESULTS: There were 187 (20.7%) of the 905 @entity1 who had negative peripancreatic lymph nodes (N0), whereas 718 (79.3%) of the 905 @entity1 had lymph node @entity3 (N1). The median number of lymph nodes evaluated in the N0 group was 15 versus 18 in the N1 group (P = .12). At median follow-up of 24 months, the median survival for all @entity1 was 17.4 months, and the 5-year actuarial survival rate was 16.1%. @entity1 with lymph node @entity3 had a shorter median overall survival (16.5 months) compared with @entity1 with negative lymph nodes (25.3 months; P = .001). Compared with the total number of lymph nodes examined or total number of lymph node @entity3 , LNR was the most compelling predictor of survival. As the LNR increased, median overall survival decreased (LNR = 0, 25.3 months; LNR > 0 to 0.2, 21.7 months; LNR > 0.2 to 0.4, 15.3 months; LNR > 0.4, 12.2 months; P = .001). After adjusting for other factors associated with survival, LNR remained an independent predictor of overall survival (P < .001). CONCLUSIONS: After pancreaticoduodenectomy for @entity420 , LNR was one of the most powerful predictors of survival. LNR should be considered when stratifying @entity1 in future clinical trials.

title: Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['ductal cancer of the pancreas', 'pancreatic cancer', 'pancreatic adenocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['metastatic cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['metastatic carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma of the pancreas']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']


abstract: BACKGROUND AND AIM: Mild to moderate @entity308 is common in those with @entity65 and undertreated. We aimed to evaluate the effectiveness of internet-delivered Cognitive Behaviour Therapy (iCBT) on depressive symptom severity and adherence to medical advice and lifestyle interventions in adults with mild to moderate @entity308 and high @entity65 ( @entity65 ) risks. METHODS: Randomised double-blind, 12 week attention-controlled trial comparing an iCBT programme (E-couch) with an internet-delivered attention control health information package (HealthWatch, n = 282). The primary outcome was @entity308 symptom level on the nine-item @entity1 Health Questionnaire (PHQ-9) (trial registration: ACTRN12610000085077). RESULTS: 487/562 (88%) @entity1 completed the endpoint assessment. 383/562 (70%) were currently treated for @entity65 and 314/562 (56%) had at least one other comorbid condition. In ITT analysis of 562 @entity1 iCBT produced a greater decline in the mean PHQ-9 score compared to the attention control of 1.06 (95% CI: 0.23-1.89) points, with differences between the two arms increasing over the intervention period (time by treatment effect interaction p = .012). There were also larger improvements in adherence (2.16 points; 95% CI: 0.33-3.99), reductions in @entity148 (0.96 points; 95% CI: 0.19-1.73), and a greater proportion engaging in beneficial physical activity (Odds Ratio 1.91, 95%CI: 1.01-3.61) in the iCBT @entity1 but no effect upon disability, or walking time/day. There were no withdrawals due to study related adverse events. CONCLUSIONS: In @entity1 with mild to moderate @entity308 and high levels of @entity65 risk factors, a freely accessible iCBT programme (http://www.ecouch.anu.edu.au) produced a small, but robust, improvement in @entity308 , adherence and some health behaviours. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry ACTRN12610000085077.

title: Internet-delivered cognitive behavioural therapy for adults with mild to moderate @entity308 and high XXXX risks: a randomised attention-controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patient', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']


abstract: AIMS: To determine whether @entity191 and @entity9576 each has a distinct pattern of micturition abnormalities and whether a urodynamic evaluation could be useful in the differential diagnosis between the two diseases. METHODS: Sixty two @entity1 (30 with @entity191 and 32 with @entity9576 ) underwent a complete urodynamic evaluation and neurophysiological testing. RESULTS: Of the @entity191 @entity1 36.6% had normal micturition findings with normal bladder sensitivity; 26.7% had delayed or incomplete pelvic floor relaxation; 26.7% had @entity427 with vesicosphincteric synergy; and 10% had @entity427 with @entity3087 . @entity191 @entity1 with a normal urodynamic pattern had significantly less severe disease and a shorter duration of disease in years than those who had abnormal patterns. @entity1 with @entity427 had significantly higher severity of disease. All the @entity1 with @entity9576 had @entity427 with synergy. Two urodynamic patterns were identified: @entity427 with vesicosphincteric synergy (90.6% of @entity1 ), and @entity427 with @entity3087 (in 9.4%). @entity427 with synergy correlated neither with the severity nor with the duration of disease. Sphincter EMG analysis showed that all the @entity191 @entity1 had normal sphincter EMG whereas 24 of the 32 @entity1 with @entity9576 had neurogenic signs. CONCLUSIONS: Urodynamic evaluation and sphincter EMG are both useful tests in the differential diagnosis between @entity191 and @entity9576 . Urodynamic findings may be abnormal before @entity1 with @entity9576 reach an advanced stage of the disease. Recordings of EMGs from perineal muscles become abnormal as the disease progresses in @entity9576 but not in @entity191 .

title: Urodynamic and neurophysiological evaluation in XXXX and @entity9576 .

entities_list: @entity3087 :: ('MESH:D059952', 'Disease') :: ['vesicosphincteric synergy and incomplete pelvic floor relaxation', 'vesicosphincteric synergy associated with incomplete pelvic floor relaxation']

entities_list: @entity9576 :: ('MESH:D019578', 'Disease') :: ['multiple system atrophy']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ['Parkinsonian', "Parkinson's disease", 'parkinsonian']

entities_list: @entity427 :: ('MESH:D012021', 'Disease') :: ['Hyperreflexia', 'hyperreflexia']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: Problems with sexuality and intimacy in @entity135 are under reported. This study set out to describe @entity1 self-reporting of intimacy and @entity250 following treatment and to explore associations with @entity1 characteristics. @entity1 treated for primary @entity213 , alive and disease free, were identified from the University Hospital Aintree @entity135 database, January 2000 to December 2006. A postal survey with two questions from the European Organisation for Research and Treatment of @entity5 Quality of Life questionnaire-Head and Neck 35 (EORTC H_N35) regarding sexuality, a self-designed question about intimacy and the University of Washington quality of life questionnaire Version 4 (UW-QOL v4) was sent to @entity1 in March 2007. There was a 68% response (350/518). One-third of those answering the intimacy and sexuality questions reported substantial problems with sexual interest and enjoyment, and one-quarter reported problems with intimacy. Intimacy problems declined with age from 36% if aged under 55 years to 6% for those 75 years and older. Intimacy and sexuality issues were largely unrelated to site, stage of disease, treatment modality and time since surgery. Gender and having a spouse or partner were related to answering the questions but not to having problems. With one-quarter of responders reporting intimacy problems it is surprising how little information and support regarding intimacy and @entity250 is offered to @entity1 and their carers. There is a need to explore these issues more extensively with further research.

title: Issues of intimacy and @entity250 following major XXXX treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'Head and Neck Cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']


abstract: BACKGROUND AND PURPOSE: It is known that @entity731 does not involve both carotid arteries to the same extent. Pathological investigations have demonstrated that lesions develop in regions of low wall shear stress. The aims of the present study were to verify the degree of @entity2998 asymmetry in a population-based study and to evaluate whether wall shear stress is lower in carotids with @entity731 than in carotids without lesions. METHODS: @entity1 in a @entity65 prevention campaign (n = 1166) were screened for @entity2998 by echo-Doppler examination. Of these, 23 subjects who presented plaque in the common carotid or bulb of one side and no plaque in the contralateral carotid tree were enrolled for common carotid wall shear stress measurement. Shear stress was calculated according to the following formula: Shear Stress = Blood Viscosity x Blood Velocity/Internal Diameter. RESULTS: Of the 1166 subjects screened, 400 (34%) had plaque and/or @entity850 in the carotids. Ninety subjects had lesions exclusively in the right carotid, 111 had lesions exclusively in the left, 70 had lesions in both carotids but with different degrees of severity, and only 129 had similar lesions in both carotids. In the 23 subjects in whom wall shear stress was measured, peak shear stress was 18.7 +/- 4.1 and 15.3 +/- 4.0 dynes.cm-2 (mean +/- SD) (P < .0001) in the side without and the side with plaque, respectively. Mean shear stress yielded similar results. CONCLUSIONS: The present results demonstrate that the @entity731 involvement of carotid arteries is usually asymmetrical and that wall shear stress is lower in the carotid arteries where plaques are present than in plaque-free arteries. These findings provide in vivo evidence for a strong association between shear stress and @entity731 .

title: In vivo association between low wall shear stress and plaque in subjects with asymmetrical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis', 'atherosclerotic lesions']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']


abstract: The results of surgical treatment of post-infarction @entity1002 in 49 @entity1 with @entity712 preoperatively were analyzed. Average @entity1 age was 55 years. Preoperative total ejection fraction averaged 30.5 +/- 1.5% (mean +/- SEM), contractile segment ejection fraction was 42.5 +/- 1.1% and end-diastolic volume of @entity439 was 81.4 +/- 10.4 ml. Seventy eight percent of @entity1 underwent coronary artery bypass grafting concomitantly with aneurysmectomy. Mean follow-up after operation was 41.5 +/- 3.5 months. Hospital mortality was 8.2%, the 5 year survival rate was 70 +/- 7% and the 5 year complication free rate was 52 +/- 8%. Mean functional class of @entity1353 improved significantly from 2.9 +/- 0.1 preoperatively to 1.6 +/- 0.1 at late follow-up (p less than 0.001). Likewise, isotopic ejection fraction at rest increased from 13.7 +/- 1.3% preoperatively to 30.9 +/- 3.0% postoperatively (p less than 0.0001). Logistic regression analysis isolated two factors which influenced postoperative survival independently: contractile segment ejection fraction (p = 0.045) and myocardial score of left anterior descending coronary artery (p = 0.035). Combining these two risk factors, it was possible to identify a low risk group of @entity1 with a 5 year survival probability of 93 +/- 6%, contrasting with a high risk group of @entity1 having a 5 year survival of 57 +/- 9% (p less than 0.02). Thus, resection of @entity1002 complicated by @entity712 provides improvement in left ventricular function and clinical status.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX complicated by @entity712 : an analysis of long-term results and risk factors of surgical treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular aneurysms']

answer: @entity1002 :: (MESH:D018487,Disease) :: ['Left ventricular aneurysm']


abstract: INTRODUCTION: Beh  et's disease is a systemic, chronic, relapsing inflammatory disease of unknown etiology characterized by recurrent oral aphthae, genital ulcerations and @entity1596 . The main pathological mechanism is @entity3144 . CLINICAL CASE: We present the case of a @entity1 with Beh  et's disease that presented as a relapsing @entity5422 with lymphocytic pleocytosis and high protein levels in cerebrospinal fluid. The MRI revealed a lesion in the brain stem and part of diencephalon. CONCLUSIONS: The central nervous system is involved in up to 5%-20% of @entity1 with Beh  et's disease, this being the first manifestation in 3% of the cases. Clinical course includes: @entity1 with an isolated episode with complete or incomplete recovery, relapsing and remitting forms, progressive forms or asymptomatic @entity16 . The most frequent presentation is relapsing @entity5422 , with progressive course localized in the brain stem. Prognosis varies according to the type of neurologic process. The worse outcome is in the parenchymal forms with brain stem and @entity602 . It also depends on the pathological findings in the cerebrospinal fluid, and the number of total events or recurrences after tapering the glucocorticoids. Mortality rate is high, up to 20% of cases after 7 years in @entity1 with @entity16 .

title: [Relapsing XXXX as onset of Beh  et's disease].

entities_list: @entity5422 :: ('MESH:D008590', 'Disease') :: ['meningoencephalitis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological involvement']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord involvement']

entities_list: @entity3144 :: ('MESH:C535509', 'Disease') :: ['leukocytoclastic vasculitis']

answer: @entity5422 :: (MESH:D008590,Disease) :: ['meningoencephalitis']


abstract: BACKGROUND AND PURPOSE: Despite similar clinical onset, recovery from @entity64 can be largely variable. We searched for electrophysiological prognostic indices, believing that they can guide future neuromodulation treatments boosting clinical recovery. METHODS: 19-channels resting electroencephalogram (EEG) was collected in 42 @entity1 after 4-10 days (t0) from a unilateral @entity385 in the middle cerebral artery (MCA) territory and 20 controls. National Health Institute @entity64 Scale (NIHSS) was collected at t0 and 6 months later (t1). Standard spectral band powers and interhemispheric coherences between homologous MCA regions were calculated in both hemispheres. RESULTS: Total spectral, delta and theta band powers were higher bilaterally in @entity1 than in controls and directly correlated with NIHSSt0 in both hemispheres. A linear regression model including each EEG @entity1 's variable differing from those of controls and correlating with effective recovery [ER = (NIHSSt0-NIHSSt1)/(NIHSSt0-NIHSS in healthy conditions)] showed contralesional delta power as the only valid predictor of ER. A further regression model including also NIHSSt0 confirmed that contralesional delta power can add prognostic information to acute clinical impairment. Contralesional delta activity increase was best explained, in addition to the increasing ipsilesional delta activity, by a reduction of interhemispheric functional coupling--which did not explain a significantly portion of effective recovery variability by itself. CONCLUSIONS: Contralesional EEG delta activity retains relevant negative prognostic information in @entity64 @entity1 . Present results point to the interhemispheric interplay as a decisive target in setting up enriched rehabilitations.

title: A contralesional EEG power increase mediated by interhemispheric disconnection provides negative prognosis in XXXX .

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke', 'acute stroke']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['acute stroke']


abstract: OBJECTIVE: The purpose of this series is to describe findings seen on abdominal sonography in neonates with erosion into the liver by umbilical vein catheters (UVCs). METHODS: Four neonates with erosion of the UVC into hepatic parenchyma within a 2-year period were identified. A retrospective case analysis was performed to determine the symptoms and clinical scenario of presentation. Plain radiographs were examined to establish the location of the UVC placement, and abdominal sonograms were reviewed. RESULTS: All 4 neonates had abdominal distension within 9 days of UVC placement, and in all of them, the UVC tip was located below the hemidiaphragm and superimposed over the liver. Sonographic examination of all @entity1 showed @entity409 with an echogenic rim and hypoechoic center. Two neonates also had subcapsular fluid collections. Complex @entity843 was seen in all 4 @entity1 . The fluid was proven to be total parenteral nutrition by paracentesis in 2 @entity1 . Treatment consisted of removal of the UVC. All @entity1 were followed for a period of 2 to 18 months and showed clinical resolution of symptoms or sonographic improvement of the @entity409 . CONCLUSIONS: A characteristic liver lesion can be seen on sonography with @entity99 by UVCs. Our study shows the importance of a high index of suspicion of UVC erosion into the liver in neonates with catheters positioned in the liver. When such neonates have abdominal distension, prompt abdominal sonograms should be obtained.

title: Characteristic sonographic findings of XXXX by umbilical vein catheters.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['intraparenchymal liver lesions', 'liver lesions']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic erosion']

answer: @entity99 :: (MESH:D056486,Disease) :: ['hepatic erosion']


abstract: OBJECTIVE: To explore the applications of karyotypic analysis in the diagnosis and prognosis of @entity2590 ( @entity2590 ). METHODS: Chromosomal analysis was performed with short-term cell cultures and R-banding techniques in 129 @entity2590 @entity1 . And the technique of FISH was employed for clinical follow-ups in 28 @entity2590 @entity1 . Based on the result of abnormal karyotype, the @entity1 were divided into three groups: low risk group , intermediate risk and high risk group. The @entity1778 transformation time and survival time between these three groups were compare. RESULTS: Among them, 52 @entity1 (40.3%) had numeral karyotypic abnormalities of chromosomes and structural alterations. Complex abnormal karyotype was the most common and accounted for 30.8% (16 cases). The frequencies of 20q(-) and +8 were 19.2% (10 cases) and 15.4% (8 cases)respectively. Six cases were positive by FISH, however, of whom, were negative for conventional cytogenetics. The follow-up data were available in 88 @entity1 with a median follow up duration of 11(3, 60) months, 27 cases (30.7%) progressed to @entity3052 . The rate of @entity1778 transformation were 27.8% (15/54), 23.5% (4/17) and 47.1% (8/17) in the low, intermediate and high risk groups respectively. The median durations of @entity1778 were > 60 (14, > 60), 48 (35, > 60) and 7 (6, 12) months in the low, intermediate and high-risk groups and the median survival times were 26(15, > 60), 21(14, 35) and 10(6, 13) months respectively. The median durations of @entity1778 and median survival periods in the high-risk groups were shorter than those in the low and intermediate risk groups (all P < 0.05). CONCLUSION: Karyotypic analysis has important values in the diagnosis and prognosis of @entity2590 .

title: [Application of karyotypic analysis in XXXX ].

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemic transformation', 'leukemia']

entities_list: @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'MDS']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia']

answer: @entity2590 :: (MESH:D009190,Disease) :: ['myelodysplastic syndrome']


abstract: @entity309 ( @entity309 ) is a chronic @entity32 affecting the joints that can lead to @entity717 . The prolonged use of conventionally used drugs is associated with severe adverse reactions. Therefore, safer and less expensive therapeutic products are continually being sought. Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity. In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic @entity32 and tissue damage, namely, chemokines and matrix-metalloproteinases (MMPs) in the @entity35 @entity1753 ( @entity1753 ) model of @entity309 . We treated arthritic Lewis @entity35 with HLXL (2.3   g/kg) by daily gavage beginning at the onset of @entity1753 . The control @entity35 received the vehicle. At the peak phase of @entity1753 , @entity35 were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested. The HLXL-treated @entity35 showed a significant reduction in the levels of chemokines ( @entity16620 , @entity4647 , @entity9269 , and GRO/KC), MMPs ( @entity33238 ), as well as cytokines ( @entity568 and @entity7940 ) that induce them, compared to the control vehicle-treated @entity35 . Thus, HLXL controls @entity625 in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for @entity309 .

title: Modified huo-luo-xiao-ling dan suppresses XXXX by inhibiting chemokines and matrix-degrading enzymes.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'inflammatory disease']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['adjuvant-induced arthritis', 'AA']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['deformities and disability']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['Rheumatoid arthritis', 'RA']

answer: @entity1753 :: (MESH:D001169,Disease) :: ['adjuvant arthritis']


abstract: The study presented a @entity1 with asymptomatic @entity356 , in whom the first symptom was @entity3 to the brain. The @entity1 was initially diagnosed by a neurologist and subject to surgical intervention in the area of residence, where he underwent craniotomy with the excision of the metastatic lesions located in the occipital lobe. The histopathological examination revealed the presence of @entity420 @entity3 . Following complex diagnostics the @entity1 was diagnosed with @entity189 , being subject to cerebral radiotherapy and chemotherapy. The @entity1 was then referred to surgery at the @entity5 Center in Pozna  . After final exclusion of disease dissemination (by means of PET-CT) the @entity1 underwent total gastrectomy with D2 lymphadenectomy, and gastrointestinal tract reconstruction by means of the Roux-en-Y method. The histopathological examination result was as follows: tubular-papillary G2 @entity420 (intestinal type), pT2 pN0 (23 evaluated lymph nodes without cancer @entity3 ), @entity1350 , and positive @entity1722 protein expression. After surgery the @entity1 was subject to adjuvant chemotherapy. Control brain CT examinations revealed the presence of 4 recurrent metastatic lesions-the @entity1 was disqualified from stereotactic radiation therapy and was subject to palliative chemotherapy. The discussion presented the problem of treating @entity1 with stage IV @entity356 , including current management guidelines, as well as literature review concerning the treatment of @entity1 with diagnosed @entity356 and brain @entity3 .

title: Brain XXXX as the first symptom of @entity356 --case report and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Wielkopolska Cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['cardial carcinoma']

entities_list: @entity1350 :: ('MESH:D019043', 'Disease') :: ['vascular neoplastic emboli']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: Obese and sedentary @entity1 have increased risk for @entity5 ; @entity32 is a hypothesized mechanism. We examined the effects of a caloric restriction @entity353 diet and exercise on inflammatory biomarkers in 439 @entity1 . Overweight and @entity28 postmenopausal @entity1 were randomized to 1-year: caloric restriction diet (goal of 10% @entity353 , N = 118), aerobic exercise (225 min/wk of moderate-to-vigorous activity, N = 117), combined diet + exercise (N = 117), or control (N = 87). Baseline and 1-year high-sensitivity C-reactive protein (hs- @entity1851 ), @entity5475 ( @entity5475 ), @entity650 ( @entity650 ), leukocyte, and neutrophil levels were measured by investigators blind to group. Inflammatory biomarker changes were compared using generalized estimating equations. Models were adjusted for baseline body mass index (BMI), race/ethnicity, and age. Four hundred and thirty-eight (N = 1 in diet + exercise group was excluded) were analyzed. Relative to controls, hs- @entity1851 decreased by geometric mean (95% confidence interval, P value): 0.92 mg/L (0.53-1.31, P < 0.001) in the diet and 0.87 mg/L (0.51-1.23, P < 0.0001) in the diet + exercise groups. @entity650 decreased by 0.34 pg/mL (0.13-0.55, P = 0.001) in the diet and 0.32 pg/mL (0.15-0.49, P < 0.001) in the diet + exercise groups. Neutrophil counts decreased by 0.31 * 10(9)/L (0.09-0.54, P = 0.006) in the diet and 0.30 * 10(9)/L (0.09-0.50, P = 0.005) in the diet + exercise groups. Diet and diet + exercise @entity1 with 5% or more @entity353 reduced inflammatory biomarkers (hs- @entity1851 , @entity5475 , and @entity650 ) compared with controls. The diet and diet + exercise groups reduced hs- @entity1851 in all subgroups of baseline BMI, waist circumference, @entity1851 level, and fasting @entity413 . Our findings indicate that a caloric restriction @entity353 diet with or without exercise reduces biomarkers of @entity32 in postmenopausal @entity1 , with potential clinical significance for @entity5 risk reduction.

title: Effects of a caloric restriction @entity353 diet and exercise on inflammatory biomarkers in overweight/ XXXX postmenopausal @entity1 : a randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'persons']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: PURPOSE: To investigate the clinical features and prognosis of @entity3557 ( @entity3557 ) with a background of benign disease. METHOD: A total of 709 @entity1 with @entity3557 undergoing surgical resection were analyzed retrospectively. In 147 @entity1 who underwent surgery for @entity1374 , incidental @entity3557 (IPC group) were identified by intraoperative or postoperative pathological examination of surgical specimens but were not detected by preoperative imaging studies. In the other group, according to the pathological examination with or without co-existing @entity1374 , 253 cases were clarified as concomitant @entity3557 and 309 cases were clarified as dominant @entity3557 . RESULTS: Incidental @entity3557 was more common in @entity1 , about 85.7%, the mean age was 47.6  11.3 years old. Average @entity5 diameter was 4.4  2.2 mm, multiple lesions accounted for 12.9% (19/147), and the cervical lymph node @entity3 rate was 6.1% (9/147). After radical resection 8 cases recurred, the median time of recurrence was about 12 months (0.5 to 162), there was no @entity5 -related @entity204 . The @entity5 -free survival rates were 97.3%, 95.9%, 91.5%, and 79.3% in 1, 5, 10 and 14 year respectively. CONCLUSION: Incidental @entity3557 with a background of benign lesions is common, and the generally good prognosis can be attributed to @entity5 early detection and early treatment. On the intraoperative finding of incidental @entity3557 , lobectomy (unilateral) or total thyroidectomy (bilateral) should be the first choice, but with a postoperative pathologic finding of incidental @entity3557 , further treatment, such as completion thyroidectomy or immediate lymph dissection is not necessary. Central lymph node dissection is also not needed unless lymphadenectasis is present.

title: Clinical features and prognosis of @entity1 with XXXX accompanied by an incidental papillary carcinoma.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['benign thyroid disease']

answer: @entity1374 :: (MESH:D013959,Disease) :: ['benign thyroid disease']


abstract: PURPOSE: To assess the effect of @entity1028 ( @entity1028 ) size on overall @entity439 morphology with special attention to possible relationships among various anatomic variables that determine the feasibility of endovascular repair. METHODS: One hundred sixty-eight @entity1 were assessed with spiral computed tomographic angiography to measure the length and diameter of the @entity1028 , the proximal neck, and the common iliac arteries. Anatomic variables were correlated with @entity439 size using Spearman's rank order correlation coefficients (rS); comparisons among small, intermediate, and large @entity439 were made using the Chi-square test. RESULTS: Correlations between @entity439 size and the anatomic variables above were weak. The strongest association was between @entity439 size and aortic length (rS = 0.41, p < 0.001). Subgroup analysis showed no difference in proximal neck length, neck diameter, or overall suitability for endovascular repair between @entity439 greater or smaller than 5.5-cm diameter. However, significantly more short (< 1.5 cm), wide (> 3 cm), and hence, unsuitable proximal necks were found in @entity1 with @entity439 > 7 cm in diameter (chi 2 = 7.8, p < 0.01). CONCLUSIONS: Shortening and widening of the proximal neck seems to increase with @entity439 size but only after the @entity439 expands beyond 7 cm in diameter. @entity439 with diameters in the 4.5- to 5.5-cm range are no more suitable for endovascular repair than those between 5.5 and 7 cm. The lack of any significant correlation between anatomic variables emphasizes the need for accurate preoperative assessment of the anatomy of each individual @entity1 before endovascular repair.

title: Influence of XXXX size on the feasibility of endovascular repair.

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'Aneurysms']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: AIM: The association between @entity1028 ( @entity1028 ) and @entity703 is becoming more frequent, raising several questions about therapeutic and surgical strategies of management for both diseases. METHODS: Between October 1988 and May 2004, 913 @entity1028 @entity1 underwent surgical or endovascular repair at the I Division of General Surgery of the University of Verona (Italy). In 61 cases (6.7%) an association with a solid @entity5 was found; in 12 cases (1.3%) the @entity5 was a @entity1358 . RESULTS: Ten @entity1 underwent a simultaneous approach to @entity1028 and @entity703 , with aneurismectomy performed first. In 2 cases a two-stage procedure was preferred; 1 @entity1 underwent aneurismectomy first for @entity1755 while a second @entity1 was even affected by @entity356 and was submitted to nephrectomy and total gastrectomy as primary procedures. There was no mortality and only one @entity260 was registered. CONCLUSIONS: A simultaneous surgical approach can be done safely, performing aneurismectomy as first step without significant risk of graft infection. Simultaneous treatment has the advantage of avoiding a second major abdominal procedure and eliminate the risk of postoperative @entity1755 . Performing a two-stage approach, the procedure for the disease regarded as life-threatening is performed first. Priority should be given to @entity703 in selected cases.

title: Surgical treatment of @entity1028 with XXXX : a single-centre experience with review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1755 :: ('MESH:D001019', 'Disease') :: ['AAA rupture', 'aortic aneurysm rupture']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complication']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer', 'renal cell neoplasm']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['concomitant renal cell carcinoma']


abstract: STUDY DESIGN: Randomized, double-blind, placebo-controlled study, with a six-month follow-up period. OBJECTIVES: To test the hypothesis that a 72-hour dose of subanesthetic @entity3652 in this surgical procedure reduces postoperative @entity1286 use; To assess if there are fewer adverse effects, if postoperative recovery is faster, if there is less peri-incisional @entity1931 or if there is lower incidence of persistent postsurgical @entity158 . SUMMARY OF BACKGROUND DATA: Tissue injury and high opioid requirements following posterior spinal fusion surgery produce central sensitization, which can in turn be associated with @entity1931 and @entity1118 . Clinical trials involving this type of procedure using subanesthetic @entity3652 doses have assessed @entity158 and @entity1286 requirements with contradictory results. The effects of prolonged subanesthetic @entity3652 doses on postoperative recovery, mechanical @entity1931 and the incidence of @entity1118 are unknown. METHODS: A total of 48 pediatric @entity1 between 10 and 18 years diagnosed with @entity2112 were randomized to receive perioperative low-dose @entity3652 or placebo for 72hours. They received general anesthesia, intraoperative @entity1937 and @entity1286 postoperatively ( @entity1 -controlled analgesia). We measured @entity1286 consumption, @entity158 at rest and during movement (coughing), undesirable effects and sedation during @entity1286 treatment. The onset of oral intake, ambulation and hospital stay were recorded. The extent of the peri-incisional @entity1931 was measured at 72hours and @entity158 controls were conducted post-surgery. RESULTS: Primary endpoint results (total cumulative @entity1286 consumption while admitted) were obtained in 44 @entity1 . Results were 2.72 (SD 1.13) in the placebo group and 3.13 (SD 1.13) in the study group (P=0.2903), with no significant differences. Moreover, differences were not found between the experimental group and the placebo group in the secondary endpoints analyzed. CONCLUSIONS: Our findings do not support the routine combining of prolonged subanesthetic @entity3652 doses with opioids in posterior fusion surgery in @entity1 with @entity2112 . LEVEL OF EVIDENCE: 2.

title: Prolonged Perioperative Low-Dose XXXX Does Not Improve Short and Long-term Outcomes After Pediatric @entity2112 Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia']

entities_list: @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']

answer: @entity3652 :: (MESH:D007649,Chemical) :: ['Ketamine']


abstract: PURPOSE: The purpose of this study was to analyze @entity3194 (ICG) angiographic findings of Dalen-Fuchs nodules in @entity7375 . METHODS: ICG angiograms of 15 @entity1 (30 eyes) with Dalen-Fuchs nodules in VKH disease of between 2 months and 5 years after the initial diagnosis were retrospectively studied. Findings of ICG angiography were compared with features of fundus @entity941 angiography (FFA). RESULTS: Dalen-Fuchs nodules were easily found in the inferior (30 eyes, 100%) and temporal periphery (22 eyes, 73%) and showed two kinds of fluorescence in ICG angiography. In ten @entity1 (20 eyes), the nodules showed small round hypofluorescent dark dots in the whole process of angiography, and the dark dots were larger in size than the nodules in FFA. Disease course in these @entity1 was relatively long-between 1 year and 5 years. On clinical examination, the nodules were @entity3202 , and @entity2117 was found around them. In another five @entity1 (ten eyes), parts of the nodules showed small hyperfluorescent dots in the early phase, but they were faint in the intermediate phase and became large, hypofluorescent dark dots in the late phase. Disease course in these @entity1 was between 2 and 8 months. The nodules were bright yellow, fresh, and much larger than those in the first kind of ICG fluorescence. CONCLUSIONS: Dalen-Fuchs nodules in VKH are mostly present in the inferior and temporal periphery. The two kinds of fluorescence of Dalen-Fuchs in ICG angiography may reflect obliteration of choriocapillaris under the nodules and different quantities of @entity6973 in the nodules at different time points of the disease.

title: Indocyanine green angiographic findings of Dalen-Fuchs nodules in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation']

entities_list: @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green']

entities_list: @entity6973 :: ('MESH:D008062', 'Chemical') :: ['lipofuscin']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity7375 :: ('MESH:D014607', 'Disease') :: ['Vogt-Koyanagi-Harada (VKH) disease']

answer: @entity7375 :: (MESH:D014607,Disease) :: ['Vogt-Koyanagi-Harada disease']


abstract: Although the addition of atrial sensing in dual chamber ICDs may improve the ability of the device to discriminate between @entity4710 ( @entity4710 ) and @entity1165 ( @entity1165 ), @entity955 may also negatively affect @entity591 classification. This prospective study evaluated the incidence of @entity955 in a dual chamber @entity1479 and their impact on @entity1165 / @entity4710 discrimination. In 145 @entity1 , a dual chamber @entity1479 (Defender) was implanted. Analysis of 1,241 @entity591 episodes stored during a mean follow-up of 14+/-8 months revealed @entity955 (66%) episodes. Upon expert review, device-based classification was confirmed in 509 (98%) of 522 @entity4710 episodes. No false device-based @entity4710 classification was related to @entity955 . Of 719 episodes classified as @entity1165 by the device, 645 (90%) were confirmed. There were 74 episodes of @entity1165 . Of these, 63 were related to @entity955 : atrial undersensing in 58 (92%) and @entity955 in 5 (8%) episodes. Atrial sensing errors led to incorrect @entity1165 / @entity4710 discrimination in 51 (4%) of 1,241 episodes. Only the occurrence of @entity955 and abdominal site of device implantation showed a significant influence on false @entity1165 / @entity4710 discrimination. Atrial sensing errors are frequently encountered in dual chamber ICDs. Due to the @entity1165 / @entity4710 discrimination algorithm, @entity955 only led to misclassification in 4 % of all episodes, mainly due to atrial undersensing. No @entity1165 underdetection due to @entity955 occurred.

title: Discrimination between ventricular and XXXX by dual chamber cardioverter defibrillators: importance of the atrial sensing function.

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia', 'false-positive VT detection']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial oversensing', 'paroxysmal atrial fibrillation', 'atrial sensing errors in 817', 'atrial sensing errors']

entities_list: @entity4710 :: ('MESH:D013617', 'Disease') :: ['supraventricular', 'SVT']

answer: @entity4710 :: (MESH:D013617,Disease) :: ['supraventricular tachycardia']


abstract: Behavioral and endocrine changes in the sow following injection with @entity3774 (PGF2 alpha) or its analogue, @entity2669 ( @entity16973 ), were monitored to identify endocrine correlates of prepartum activity (nest-building). On Day 112 postcoitum, within 15 min after injection with 10 mg PGF2 alpha, sows offered straw in pens engaged in intense prepartum activity, but few behavioral changes occurred during the first 2 h following administration of 175 micrograms CLO. The temporal pattern of prepartum activity, however, was affected by both @entity2918 . In control sows, most prepartum activity came during Hours 16-0 before delivery of first piglet (delivery). After CLO, sows engaged in nest-building more during Hours 32-17 and less during Hours 16-0. In another experiment, sows in farrowing crates were injected with saline, 175 micrograms CLO, or 10 mg PGF2 alpha on Day 112 and blood was collected 0, 15, 30, 60, and 90 min later. Another sample was collected when spontaneous prepartum activity was first observed. For approximately 90 min after PGF2 alpha treatment, sows rooted, pawed, and bit and rubbed faces on crate bars; after saline and CLO, this behavior was rarely observed. After prostaglandin treatment, plasma @entity1420 tended to decline, a 10-fold rise in relaxin came within 15 min, but @entity1815 did not change. Plasma prolactin rose 10-fold within 30 min after PGF2 alpha treatment, and rose more gradually after CLO treatment. When sows exhibited spontaneous prepartum activity (approximately 7 h before delivery), endocrine status was characterized by low @entity1420 , high @entity1815 : @entity1420 ratio, and high prolactin.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Behavioral and endocrine responses of sows to XXXX and @entity2669 .

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins']

entities_list: @entity2669 :: ('MESH:D003008', 'Chemical') :: ['cloprostenol']

entities_list: @entity3774 :: ('MESH:D015237', 'Chemical') :: ['prostaglandin F2 alpha']

answer: @entity3774 :: (MESH:D015237,Chemical) :: ['prostaglandin F2 alpha']


abstract: BACKGROUND: Individualized prediction of outcomes may help with therapy decisions for @entity1 with @entity1149 . We developed a nomogram by analyzing 17 clinical factors and outcomes from a randomized study of sublobar resection for @entity1149 in high-risk operable @entity1 . The study compared sublobar resection alone with sublobar resection with brachytherapy. There were no differences in primary and secondary outcomes between the study arms, and they were therefore combined for this analysis. METHODS: The clinical factors of interest (considered as continuous variables) were assessed in a univariate Cox proportional hazards model for significance at the 0.10 level for their impact on @entity1349 ( @entity1349 ), local @entity1349 (LRFS), and any @entity1349 ( @entity1349 ). The final multivariable model was developed using a stepwise model selection. RESULTS: Of 212 @entity1 , 173 had complete data on all 17 risk factors. Median follow-up was 4.94 years (range, 0.04 to 6.22). The 5-year @entity1349 , LRFS, and @entity1349 were 58.4%, 53.2%, and 47.4%, respectively. Age, baseline percent diffusing capacity of lung for @entity1223 , and maximum @entity5 diameter were significant predictors for @entity1349 , LRFS, and @entity1349 in the multivariable model. Nomograms were subsequently developed for predicting 5-year @entity1349 , LRFS, and @entity1349 . CONCLUSIONS: Age, baseline percent diffusing capacity of lung for @entity1223 , and maximum @entity5 diameter significantly predicted outcomes after sublobar resection. Such nomograms may be helpful for treatment planning in early stage @entity1149 and to guide future studies.

title: A Nomogram to Predict Recurrence and Survival of High-Risk XXXX Undergoing Sublobar Resection for Lung Cancer: An Analysis of a Multicenter Prospective Study (ACOSOG Z4032).

entities_list: @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: Among indirect measures of @entity10478 , A Body Shape Index (ABSI), which is defined as waist circumference (WC)/(body mass index (BMI)(2/3)*height(1/2)), is unique in that ABSI is positively correlated with @entity10478 and is supposed to be independent of BMI. ABSI has been also shown to be linearly and positively associated with visceral fat mass and all-cause and @entity65 ( @entity65 ) in the general population. It is, however, uncertain whether ABSI could be associated with @entity432 in @entity1 with @entity6 . METHODS: This is a cross-sectional study of 607 @entity1 with @entity164 2 @entity6 (mean age 64  12   years; 40.0% female). Visceral fat area (VFA, cm(2)) and subcutaneous fat area (SFA, cm(2)) were assessed with a dual-impedance analyzer. In order to estimate the risk for @entity65 , brachial-ankle pulse wave velocity (baPWV, cm) was used for the assessment of @entity432 . RESULTS: ABSI was significantly and positively correlated with VFA (r=0.138, p=0.001) and negatively associated with BMI (r=-0.085, p=0.037). The correlation of z-score for ABSI with VFA remained significant (r=0.170, p<0.001) but not with BMI (r=0.009, p=0.820). ABSI (standardized b 0.095, p=0.043) but not WC (standardized b -0.060, p=0.200) was significantly and positively correlated with baPWV in the multivariate model including BMI as a covariate. CONCLUSIONS: ABSI appears to reflect @entity10478 independently of BMI and to be a substantial marker of arterial stiffening in @entity1 with @entity164 2 @entity6 .

title: Indirect measure of @entity10478 'A Body Shape Index' (ABSI) is associated with @entity432 in @entity1 with XXXX 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity10478 :: ('OMIM:155310', 'Disease') :: ['visceral adiposity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial stiffness']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: The histochemical activities of succinic dehydrogenase (SDH), myofibrillar @entity859 triphosphatase (ATPase) and @entity7685 dehydrogenase were studied in serial sections of @entity35 vastus lateralis (red) (RVL), gastrocnemius and diaphragm muscles. Three main fibre-types were distinguished. The "Type I" fibres of RVL and gastrocnemius muscles fell into two distinct groups: one category--"Type IA" showed very low ATPase activity. The second category of "Type IB" fibres displayed moderate ATPase reaction. The "Type IA" fibres were divisible into two sub-groups when tested for SDH reaction. "Type IA1" fibres possessed a homogenous distribution of @entity41607 granules throughout the fibre: "Type IA2" fibres displayed characteristic "moth-eaten" pattern of diformazan localization. The diaphragm muscle did not show either " @entity5108 " varieties. The great majority of TypeI fibres were sub-type IA1 in the three fast muscles studied. It is also demonstrated here that an inherent heterogeneity exists between Type I filores of diaphragm and leg muscles in regard to alpha-GPD localization. This histochemical data emphasizes the fact that subdivision of TypeI striated muscle fibres of @entity1 animals into two sub-types is only approximate and that a further subcategorization is possible.

title: Histoenzymatic characterization of sub-types of type I fibres in fast muscles of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine']

entities_list: @entity5108 :: ('MESH:D002607', 'Disease') :: ['Type IB" or "Type IA2']

entities_list: @entity41607 :: ('MESH:C033302', 'Chemical') :: ['diformazan']

entities_list: @entity7685 :: ('MESH:C029620', 'Chemical') :: ['alpha glycerophosphate']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: @entity3564 is associated with accelerated wear rates. The goal of this study was to investigate the influence of demographic and technical variables on wear rates and size of @entity690 . Eighty retrieved ABG I prostheses were analyzed according to prospectively established criteria. There were 22 @entity1 and 58 @entity1 with an average age of 52 years (34-65) at the time of revision. The average time from index surgery to revision was 67 months (26 to 106). @entity691 wear measurements were performed using a Universal-type measuring microscope. The average linear wear and volumetric wear rate was 0.363 mm per year (0-0.939, SD 0.241) and 161 mm(3) per year (0-467, SD 118.2), respectively. The wear rates were significantly higher (a) in @entity1 with @entity571 in comparison with postdysplastic hips, (b) in hips where zirconia prosthetic heads articulated against the @entity691 liner, and (c) in cups placed laterally to Kohler's line. Risk that linear wear rate could be more than 0.2 mm per year was three times higher in @entity1 who were operated in 1997 and later (OR 3.0, 95 % CI 1.126-7.993, p = 0.03). A strong association was revealed between magnitude of wear and size of femoral @entity3061 .

title: Influence of demographic, surgical and implant variables on wear rate and XXXX in ABG I hip arthroplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['Polyethylene', 'polyethylene']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['primary osteoarthritis']

entities_list: @entity3061 :: ('MESH:D010014', 'Disease') :: ['osteolysis']

entities_list: @entity690 :: ('MESH:D030981', 'Disease') :: ['osteolytic lesions']

entities_list: @entity3564 :: ('MESH:D057068', 'Disease') :: ['Periprosthetic osteolysis']

answer: @entity3061 :: (MESH:D010014,Disease) :: ['osteolysis']


abstract: Data have shown that circulating endothelial progenitor cells (EPCs) closely correlate with the vascular endothelial layer state. The present study was designed to describe the evolution of EPCs in @entity1 before and 24 h after transcatheter closure surgery for occluding @entity299 . Three groups of @entity1 were studied: the transcatheter closure of @entity118 ( @entity118 ) group (group 1), the transcatheter closure of @entity2461 ( @entity2461 ) group (group 2), and the transcatheter closure of @entity1757 ( @entity1757 ) group (group 3). The circulating EPC level was detected using flow cytometry measuring @entity2280 and kinase insert receptor double-positive mononuclear cells. The concentration of @entity7 ( @entity7 ) was assessed by enzyme-linked immunosorbent assay. The fluoroscopy time was correctly recorded during the surgery. All of the data were collected before and 24 h after surgery. EPC level and @entity7 concentration did not change significantly before and at 24 h after surgery in groups 1 and 2. In group 3, the level of circulating EPCs and @entity7 concentration increased significantly 24 h after surgery. The fluoroscopy time in group 3 was significantly longer than in groups 1 and 2. The increased volume of EPCs and @entity7 were positively correlated in group 3. Our results showed that transcatheter closure of @entity2461 and @entity118 in @entity1 does not lead to increased circulating level of EPCs. Transcatheter closure of @entity1757 may result in vascular endothelium injury as indicated by increased circulating EPC level.

title: The circulating level of endothelial progenitor cells after transcatheter closure of XXXX in @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['VSD', 'ventricular septal defect']

entities_list: @entity2461 :: ('MESH:D004374', 'Disease') :: ['PDA', 'patent ductus arteriosus']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defect', 'ASD']

answer: @entity299 :: (MESH:D006331,Disease) :: ['congenital heart disease']


abstract: The Th-1/Th-2 paradigm proposes clonal expansion of Th-2 lymphocytes as the basis of tolerance towards allografts. Intragraft cytokine expression was evaluated in a highly stringent model of renal transplantation. ACI and Lewis @entity35 were used as donors and recipients, respectively, for heterotopic renal transplantation. Group A (n = 8) received a single dose of @entity3446 and @entity205 12 h prior to engraftment, followed by 7 d of @entity205 post-operatively. Isografts (Group B, n = 5) and control allografts (Group C, n = 4) received no immunosuppression. Sacrifice was performed after 120 d. Intragraft expression of @entity13358 , @entity12718 , and @entity3692 was determined using qualitative reverse transcriptase-polymerase chain reaction (RT-PCR). All groups had functionally normal grafts at sacrifice, with 50% histological tolerance among Group A animals. No isografts showed evidence of cellular infiltrate, and all control allografts showed severe rejection. @entity13358 was only detected in the tolerant animals (p < 0.001). Similarly, @entity12718 was detected predominantly in the tolerant allografts (p < 0.05). @entity3692 was only isolated in rejected allografts, whether treated or untreated (p < 0.001). We conclude that the expansion of Th-2 cells is associated with tolerance, while the expansion of Th-1 cell is associated with acute cellular rejection.

title: Intragraft cytokine expression in tolerant XXXX renal allografts with @entity3446 and @entity205 immunosuppression.

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: PURPOSE: @entity2112 can lead to sagittal imbalance. The relationship between thoracic hyper- and hypo-kyphotic segments, @entity717 and coronal curve was determined. The effect of segmental sagittal correction by in situ contouring was analyzed. METHODS: Pre- and post-operative radiographs of 54 @entity1635 @entity1 (Lenke 1 and 3) were analyzed at 8  years follow-up. Cobb angles and @entity717 were determined. Sagittal measurements were: @entity1513 T4-T12, T4-T8 and T9-T12, lordosis L1-S1, T12-L2 and L3-S1, pelvic incidence, pelvic tilt, sacral slope, T1 and T9 tilt. RESULTS: Thoracic and lumbar curves were significantly reduced (p  =  0.0001). Spino-pelvic parameters, T1 and T9 tilt were not modified. The global T4-T12 @entity1513 decreased by 2.1   on average (p  =  0.066). Segmental analysis evidenced a significant decrease of T4-T8 hyperkyphosis by 6.6   (p  =  0.0001) and an increase of segmental hypokyphosis T9-T12 by 5.0   (p  =  0.0001). Maximal @entity717 was located at T7, T8 or T9 and correlated (r  =  0.422) with the cranial level of the hypokyphotic zone (p  =  0.003). This vertebra or its adjacent levels corresponded to the coronal apex in 79.6  % of thoracic curves. CONCLUSIONS: Lenke 1 and 3 curves can show normal global @entity1513 , divided in cranial hyperkyphosis and @entity10145 . The cranial end of hypokyphosis corresponds to maximal rotation. These vertebrae have most migrated anteriorly and laterally. The sagittal apex between segmental hypo- and @entity1513 corresponds to the coronal thoracic apex. A segmental sagittal imbalance correction is achieved by in situ contouring. The concept of segmental imbalance is useful when determining the levels on which surgical detorsion may be focused.

title: Sagittal balance correction of XXXX using the in situ contouring technique.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1513 :: ('MESH:D007738', 'Disease') :: ['hyper-kyphosis', 'kyphosis']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['Idiopathic scoliosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['vertebral rotation']

entities_list: @entity10145 :: ('MESH:C537221', 'Disease') :: ['caudal hypokyphosis']

answer: @entity2112 :: (MESH:C564593,Disease) :: ['idiopathic scoliosis']


abstract: Control of @entity8999 ( @entity8999 ) is achieved by reducing immunosuppression allowing an effective @entity8999 -specific T-cell response. The morphology of resolving @entity8999 -associated @entity8 (PyVAN) has not been systematically investigated. Ninety-nine surveillance biopsies of 35 @entity1 with @entity8999 @entity646 treated exclusively by immunosuppression reduction were scored according to Banff criteria and grouped relative to @entity8999 @entity646 as pre-, increasing, decreasing and post- @entity8999 @entity646 . Thirty-four of 35 @entity1 (97%) cleared @entity8999 @entity646 after a median of 9 months posttransplantation. The @entity9538 score, extent of tubules with intraepithelial lymphocytes, and @entity32 significantly increased from the time of increasing to decreasing @entity646 . @entity32 , to a lower extent, persisted after clearance. The number of SV40+ tubules correlated with the @entity8999 load in plasma, but SV40 immunohistochemistry was frequently negative (60%). During decreasing @entity646 , 31% of PyVAN cases were plasma cell-rich and 40% showed tubular HLA-DR expression. Compared to baseline 1 month posttransplantation, allograft function remained stable or improved in 29/35 @entity1 (83%) after a median follow-up of 48 months. Within 1 year after clearance of @entity8999 @entity646 , clinical rejection occurred in 2/35 @entity1 (6%). Our data suggest that resolving PyVAN is typically characterized by a self-limiting acute @entity1986 , morphologically indistinguishable from interstitial rejection.

title: Pathology of resolving polyomavirus-associated XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['interstitial inflammation', 'Tubulointerstitial inflammation']

entities_list: @entity9538 :: ('MESH:D007673', 'Disease') :: ['tubulitis']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity8999 :: ('10629', 'Species') :: ['polyomavirus BK', 'BKV']

entities_list: @entity1986 :: ('MESH:D009395', 'Disease') :: ['interstitial nephritis']

answer: @entity8 :: (MESH:D007674,Disease) :: ['nephropathy']


abstract: In a previous study, we found that angiotensin (Ang) II enhances beta-adrenoceptor-induced @entity268 production in cultured preglomerular microvascular smooth muscle cells (PMVSMCs) obtained from spontaneously @entity101 @entity35 . The purpose of the present investigation was to identify the Ang receptor subtypes that mediate this effect. In our first study, we compared the ability of Ang II, Ang III, Ang (3-8), and Ang (1-7) to increase @entity268 production in @entity3044 (1 microM)-treated PMVSMCs. Each peptide was tested at 0.1, 1, 10, 100, and 1000 nM. Both Ang II and Ang III increased intracellular (EC50s, 1 and 11 nM, respectively) and extracellular (EC50s, 2 and 14 nM, respectively) @entity268 levels in a concentration-dependent fashion. In contrast, Ang (3-8) and Ang (1-7) did not enhance either intracellular or extracellular @entity268 levels at any concentration tested. In our second study, we examined the ability of @entity38354 [a selective Ang receptor subtype 1 ( @entity1809 ) receptor antagonist] to inhibit Ang II (100 nM) and Ang III (100 nM) enhancement of @entity3044 (1 microM)-induced @entity268 production in PMVSMCs. @entity38354 (10 nM) abolished or nearly abolished (p <.001) Ang II and Ang III enhancement of @entity3044 -induced intracellular and extracellular @entity268 levels. In contrast, @entity11083 (300 nM; a selective @entity11082 receptor antagonist) did not significantly alter Ang II enhancement of @entity3044 -induced intracellular or extracellular @entity268 levels. We conclude that @entity1809 receptors, but not @entity11082 , Ang (3-8), nor Ang (1-7) receptors mediate Ang II and Ang III enhancement of beta-adrenoceptor-induced @entity268 production in cultured PMVSMCs.

title: Angiotensin receptor subtype 1 mediates angiotensin II enhancement of XXXX -induced cyclic AMP production in preglomerular microvascular smooth muscle cells.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

answer: @entity3044 :: (MESH:D007545,Chemical) :: ['isoproterenol']


abstract: Recently, much interest has focussed on the potential interaction between sympathetic nervous system and global cardiovascular risk. We investigated how baroreflex sensitivity ( @entity4375 ), an index of autonomic function, interacts with @entity1144 ( @entity1144 ) in an essential @entity101 (EH) population. We selected 170 EHs and 43 normotensives (NT), (median age 47.3+/-11.3 and 49.1+/-13 years, respectively). Anthropometric parameters were measured for each and @entity4375 was evaluated by a non-invasive method using Portapres TNO. The @entity4375 evaluation was made using the sequences method. Systolic blood pressure (SBP) and heart rate were significantly higher in EH (P<0.001 and P=0.007, respectively). @entity4375 was significantly greater in NT (P=0.02), and was associated inversely with waist circumference (WC) (P=0.005), but not with SBP or with other metabolic risk factors. Body mass index, total and high-density lipoprotein @entity165 , age and WC were not significantly different between the two groups. These results were confirmed by age pounded analysis. Finally, a separate analysis of the @entity101 group with @entity1144 (n=84) demonstrated a significantly lower @entity4375 compared with the other @entity101 @entity1 (n=86) (P<0.001). @entity4375 is associated with WC but not with arterial pressure values and metabolic risk factors. @entity101 subjects with @entity1144 show an impairment of @entity4375 . Owing to its association with abdominal fat distribution and subsequently insulin resistance, @entity4375 could represent a further and reliable index for evaluation of global cardiovascular risk in @entity101 @entity1 .

title: Baroreflex sensitivity is impaired in essential @entity101 with XXXX .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive', 'hypertensive']

entities_list: @entity1144 :: ('MESH:D056128', 'Disease') :: ['CO', 'central obesity']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1144 :: (MESH:D056128,Disease) :: ['central obesity']


abstract: The widespread use of laparoscopy has been made possible by the exponential improvements in imaging technology as well as the development of specialized instruments. Although the use of laparoscopy for procedures such as cholecystectomy has become commonplace, its applicability in the management of @entity5 remains in evolution. The role of the surgeon in the care of the @entity1 with @entity706 is limited mostly to obtaining a diagnosis. Laparoscopy can play a significant role in the care of the @entity1 requiring accurate intra-abdominal staging. The staging procedure is conducted in a fashion identical to the open procedure, including multiple liver biopsies, a splenectomy, and multiple lymph node biopsies. @entity1 with @entity1893 almost never require staging, and laparoscopy may play a role in obtaining tissue for diagnosis in a small fraction of @entity1 . @entity1 with @entity978 who have @entity5 need staging because they will all receive chemotherapy. Likewise, @entity1 with @entity66 (stage I) are usually treated with radiation therapy alone. Some @entity1 with @entity34 will require surgical staging, which should be performed laparoscopically. The laparoscopic approach to this procedure may afford benefits to the @entity1 including decreased hospitalization, morbidity, and reduced delays in obtaining definitive treatment.

title: Laparoscopic interventions in XXXX management.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['limited disease']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['diffuse disease (stages III and IV) never', 'malignancies']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']

answer: @entity706 :: (MESH:D008223,Disease) :: ['lymphoma']


abstract: UNASSIGNED: Background: Obesity is a significant public health problem in the United States, and many studies have established @entity28 as a significant risk factor for @entity1204 . Surgery is the standard of care in staging and treatment of @entity1204 , and @entity28 may influence surgical outcomes because of its attendant comorbid conditions. Therefore, assessment of the impact of @entity28 on surgical outcome is important for decreasing morbidity and improving survival in @entity1 with @entity1204 . Objective: The aims of this research were to evaluate and review epidemiologic data systematically on the impact of @entity28 on surgical outcomes and to assess safety and feasibility of newer surgical techniques in @entity28 @entity1 . Materials and Methods: A systematic search of PubMed was conducted to identify articles between 2004 and 2013 that focused on the impact of @entity28 on surgical outcome. Reference lists of retrieved articles were also used to identify other relevant articles. Thirteen relevant articles were reviewed. Results: Evidence from epidemiologic studies showed that @entity28 impacts surgical outcome adversely. On average, @entity28 @entity1 have worse surgical outcomes than their nonobese counterparts. In addition, surgical outcome worsens as level of @entity28 increases. However, surgical procedure also influences this association. Minimally invasive surgeries are more useful and are accompanied with fewer complications than conventional laparotomy and can be performed safely in @entity28 @entity1 . Conclusions: Obesity is a significant risk in the etiology, treatment, and surgical outcomes of @entity1 with @entity1204 . Future research will need more randomized controlled trials and prospective studies to identify the best procedures for maximal outcomes. (J GYNECOL SURG 32:149).

title: The Impact of Obesity on Surgical Outcome in @entity1204 XXXX : A Systematic Review.

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: The exquisitely sensitive @entity302 ( @entity302 ) technique was shown to detect human leukocyte antigen (HLA) antibodies in sera of healthy male blood donors. Such false reactions can have an impact on critical decisions, especially with respect to the determination of unacceptable HLA-antigen mismatches in @entity1 awaiting a kidney transplant. We tested pretransplant sera of 534 @entity1 on the kidney waiting list using complement-dependent @entity137 (CDC), enzyme-linked immunosorbent assay (ELISA) and @entity302 in parallel. Evidence of HLA antibodies was obtained in 5% of @entity1 using CDC, 14% using ELISA, and 81% using @entity302 . Among @entity1 without history of an immunizing event, 77% showed evidence of HLA antibodies in @entity302 . In contrast 98% of these @entity1 were negative in ELISA and CDC. In @entity1 without an immunizing event, @entity302 -detected antibodies reacted not always weakly but with mean fluorescence intensity (MFI) values as high as 14 440. High-MFI-value antibodies were found in some of these @entity1 with HLA specificities that are rather common in general population, consideration of which would lead to unjustified exclusion of potential kidney donors. False @entity302 reactions can be unveiled by testing with additional antibody assays. @entity8 to recipients based on HLA-antibody specificities detected exclusively in the @entity302 assay is not advisable.

title: Influence of test technique on sensitization status of XXXX on the kidney transplant waiting list.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Denial of donor kidneys']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['single antigen bead', 'SAB']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity1 with @entity302 frequently @entity2414 , but neuropsychological tests sometimes fail to detect consistent deficits; this may be because laboratory tests are poor indicators of everyday @entity2414 , or because subjective @entity2414 may be provoked by a variety of factors. To address these issues, we compared 100 @entity1 with @entity302 and 57 healthy controls by means of our Questionnaire of Memory Efficiency, the State-Trait @entity148 Inventory, the Self-Rating @entity308 Scale and a battery of tests. The Chronbach test showed the Questionnaire of Memory Efficiency to be satisfactorily reliable. @entity1 reported significantly greater @entity2414 and higher levels of @entity148 and @entity308 than controls. Questionnaire of Memory Efficiency scores correlated with @entity148 and @entity308 levels, as well as with memory and learning test scores and regression analysis showed that @entity148 , @entity308 and visual learning had the most consistent explanatory power. No correlation was found with clinical variables or the presence of detectable @entity75 . @entity1 undergoing polytherapy or treatment for long periods reported the greatest @entity2414 . These findings suggest that subjective perception of memory failure reflects objective @entity2414 . However, emotional factors and low self-esteem may bloat the reporting of everyday @entity2414 . The Questionnaire of Memory Efficiency seems able to provide information about everyday @entity2414 in @entity1 with @entity302 that may be useful for planning neuropsychological counselling or rehabilitation.

title: Self-reporting of everyday memory in @entity1 with XXXX : relation to neuropsychological, clinical, pathological and treatment factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesion']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['complain of memory problems', 'memory problems', 'memory difficulties', 'memory impairment']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: BACKGROUND: @entity717 following motor vehicle related orthopaedic @entity130 is a significant contributor to the burden of @entity66 . Early identification of predictors for return to work (RTW) is essential for developing effective interventions to prevent @entity717 . The study aim was to determine the predictors (including compensation related factors) of time to RTW following motor vehicle related orthopaedic @entity130 . METHODS: Admitted @entity1 were recruited prospectively from two @entity130 hospitals with upper and/or lower extremity @entity174 following a motor vehicle crash. Baseline and follow up data were collected by written questionnaire. For baseline, this occurred in @entity1 within 2 weeks of injury. For follow up, this occurred by mail at six, 12 and 24 months. Additional demographic and injury-related information was retrieved from hospital databases. Analysis involved: descriptive statistics; logrank test to detect survival distributions of categorical variables; and Cox proportional hazards regression models for risks of time to RTW using baseline characteristic and compensation related variables (at 6 months). RESULTS: Of 452 study @entity1 334 (74%) were working pre-injury: results are based on this subset. Baseline characteristics were mean age 36 years (13.9 Standard Deviation [SD]), 80% male; 72% self-assessed very good-excellent pre-injury health, 83% household income > AU 40,000 (Australian Dollar). Follow up data was available for 233 (70%), 210 (63%), and 182 (54%) @entity1 at six, 12 and 24 months respectively. Significant risks of a longer time to RTW were greater injury severity, as measured by the New Injury Severity Score (NISS) (Hazards Rate Ratio [HRR]   = 0.54, 95% CI 0.35-0.82); and lower occupational skill levels (HRR   = 0.53, 95% CI 0.34-0.83). Significant risks of a shorter time to RTW were: recovery expectations for usual activities within 90 days (HRR   = 2.10, 95% CI 1.49-2.95); full-time pre- @entity130 ( @entity4961 .99, 95% CI 1.26-3.14); and very good self-assessed pre-injury health status ( @entity4961 .41, 95% CI 0.98-2.02). Legal representation (analysed at six months only) was not associated with time to RTW. At each time period, there were 146 (63%), 149 (71%), and 137 (76%) working @entity1 . CONCLUSIONS: A longer time to RTW was associated with greater injury severity and lower occupational skill levels; while a shorter time to RTW was associated with recovery expectations for usual activities within 90 days, full-time pre- @entity130 , and very good self-assessed pre-injury health status. Our findings reinforce existing research. There is an opportunity to trial interventions that address potentially modifiable factors. The issues surrounding legal representation are complex and require further research.

title: Predictors of return to work following motor vehicle related orthopaedic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'person']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['injury and disease']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['work disability', 'Work disability']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injury work hours', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: The objective of the study was to determine the effects of three dietary energy levels: 0.27 (low level: LL); 0.53 (medium level: ML), and 1.06 (high level: @entity1733 ) MJMEkg(-1)W(0.75) on estrus synchronization and fertility in Mashona @entity1237 does. Forty-five multiparous Mashona @entity1237 does of average bodyweight 19.9+/-2.5kg were randomly allocated in equal numbers to the three dietary energy levels. The diets were made from a complete feed ration providing 9.83MJMEkg(-1) @entity3918 and 15.5% CPkg(-1) @entity3918 . Does were fed initially during a 60-day pre-synchronization period, and blood samples were collected twice a week for the determination of plasma @entity1420 concentrations to ascertain ovarian activity. Intramuscular injections of @entity2669 (100  g each) were administered 11 days apart. Immediately after the second injection of @entity2669 , three fertile bucks were introduced to the does and were left with the does for 21 days. The does were maintained on their dietary treatments throughout gestation except for those does in the LL treatment. Pregnancy was diagnosed 90 days post-mating using an ultrasound scanner. After pregnancy diagnosis, does on the LL treatment were randomly allocated to ML (n=7) and @entity1733 (n=8) treatments. During the pre-synchronization period, does on the LL treatment lost 12.3% whereas those on ML and @entity1733 treatments gained 2.1 and 28.8% of their initial bodymasses, respectively. The proportion of does exhibiting overt estrus within 96h after the last @entity2669 injection was significantly lower (P<0.05) for does on the LL treatment (60%) than for those on ML (93%) or @entity1733 (100%) treatments, respectively. However, based on plasma @entity1420 concentrations, the percentage of does on the LL treatment that exhibited ovarian cycles was numerically lower than that of does that were bred (40 versus 73%). Conception, fecundity and twinning rates were significantly lower (P<0.05) on the LL treatment than on the ML and @entity1733 treatments. These results indicate that feeding Mashona @entity1237 does 0.27MJMEkg(-1)W(0.75) compared to 0.53 and 1.06MJMEkg(-1)W(0.75) reduces the expression of estrus, conception, fecundity and twinning rates, and that feeding 0.53MJMEkg(-1)W(0.75) suffices for optimum reproduction. In addition, the results suggest that @entity2669 administration may induce ovarian cycles in reproductively quiescent does on dietary energy restriction.

title: Effect of different dietary energy level intakes on efficiency of estrus synchronization and fertility in Mashona XXXX does.

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity2669 :: ('MESH:D003008', 'Chemical') :: ['cloprostenol']

answer: @entity1237 :: (9925,Species) :: ['goat']


abstract: BACKGROUND: Postoperative poor graft function is a serious complication that can lead to graft loss requiring retransplantation or even @entity204 . The postoperative complications of @entity42029 ( @entity42029 ), early @entity813 (EGD), @entity548 due to @entity1003 , and @entity715 ( @entity715 ) can lead to graft loss requiring retransplantation or even @entity204 . We determined the causes of @entity204 after liver transplantation. METHODS: This was an observational descriptive study on adult liver transplant recipients from September 1991 to December 2011. The cutoff for the definition of @entity204 was 30 days after surgery. We included @entity1 older than 18 years of age who underwent liver grafts using the piggyback technique, excluding those who had retransplantations or liver-kidney transplantations. RESULTS: We analyzed 561 liver transplantations through chart review. After application of exclusion criteria we had 81 @entity1 for analysis. Overall mortality was classified into 3 main causes: @entity42029 (34/81; 42%), EGD (10/81; 12%), and @entity548 due to @entity1003 (9/81; 11%). CONCLUSION: Despite advances, mortality in the first 30 days after surgery is still high, mainly related to the occurrence of @entity42029 and EGD, whose causality was associated with red blood cell transfusion (>5 U).

title: Assessment of causes of XXXX after twenty years of liver transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['abdominal bleeding', 'bleeding']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy']

entities_list: @entity42029 :: ('MESH:C565486', 'Disease') :: ['PNF', 'primary nonfunction']

entities_list: @entity813 :: ('MESH:D055031', 'Disease') :: ['graft dysfunction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['hepatic artery thrombosis', 'HAT']

answer: @entity204 :: (MESH:D003643,Disease) :: ['early death']


abstract: PURPOSE: The recent linkage between a genetically transmissible form of @entity302 (ADNFLE) and mutations within the alpha4 subunit, one component of the major brain neuronal nicotinic @entity934 receptor ( @entity6786 ), raises the question of the role of this receptor in epileptogenesis. Although acting by different mechanisms, the two genetic alterations so far identified both render the @entity6786 less efficient. In view of the high sensitivity of ADNFLE to @entity2049 ( @entity2050 ), we studied the effects of this drug and of @entity1092 ( @entity2052 ) on the @entity1 alpha4beta2 @entity6786 and its mutations. METHODS: The alpha4beta2 nAChRs from control and mutant alpha4 subunits were reconstituted in @entity1238 oocytes and investigated by using a dual-electrode voltage clamp technique. @entity934 ( @entity1617 )-evoked currents recorded in the absence or presence of antiepileptic drugs (AEDs) were studied to analyze the mode of action of these compounds. RESULTS: @entity1617 -evoked currents at the @entity1 alpha4beta2 @entity6786 were readily and reversibly inhibited by approximately 100 microM @entity2050 . This compound was found to be a noncompetitive inhibitor of the @entity6786 , which probably acts by entering the channel and causing a blockade by steric hindrance. Dose-response inhibition curves determined on the control receptor and on ADNFLE-mutant receptors showed a greater sensitivity of the mutants to @entity2050 , with median inhibitory concentrations (IC50s) in the range of the antiepileptic plasma levels of @entity2050 . In contrast, @entity2052 had nearly no effect on control and mutant nAChRs. CONCLUSIONS: @entity2050 inhibits the neuronal alpha4beta2 nAChRs at pharmacologic concentrations, with ADNFLE mutants displaying about threefold higher sensitivity to this compound. The increased sensitivity of these mutant receptors supports the hypothesis that the antiepileptic activity of @entity2050 can, at least to some extent, be attributed to the @entity6786 inhibition.

title: Mutated nicotinic receptors responsible for autosomal dominant nocturnal frontal lobe epilepsy are more sensitive to XXXX .

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate']

entities_list: @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine', 'Acetylcholine']

answer: @entity2049 :: (MESH:D002220,Chemical) :: ['carbamazepine']


abstract: INTRODUCTION: The objective of this investigation is to determine whether bispectral index (BIS  ) monitoring during intravenous anaesthesia with spontaneous breathing for upper @entity344 (UGE) in a pediatric population is useful for: a) decreasing the amount of drug, b) decreasing the time for awakening, and c) improving @entity1 safety. @entity1 AND METHOD: A quasi-experimental case-control prospective study was conducted in the setting of a second level hospital pediatric intensive care unit. @entity1 : @entity1 aged 1-13 years. CASE: ASA I @entity1 who needed a diagnostic UGE; eligible, 36, @entity1 , 30. CONTROL: historical cohort of @entity1 who needed UGE (years 2008-2010): 50 @entity1 . INTERVENTION: UGE performed with anaesthetic protocol, vital signs monitoring, sedation level (Ramsay scale) and BIS monitoring. VARIABLES OF INTEREST: @entity1875 total dose (mg/kg), induction time, time in performing the UGE, awakening time (min); initial BIS (iBIS), and BIS during the UGE; adverse effects. RESULTS: There were no significant differences in sex, age or weight between case (B) and control (C) population. No significant differences in total @entity1875 doses: (B 4.9    1.4 mg/kg; C 5.2    1.6 mg/kg, P=.492), awakening time (B 12.2    4.6 min; C 12.8    4.4 min, P=.402), time for execution of UGE (B 9.5    4.8 min; C 11.3    6.5 min, P=.335) and induction time (B 11.1    2.6 min; C 10.1    4.2 min, P=.059), iBIS 55.4    6.9. There were no significant differences in adverse effects: 2 @entity1 suffered from mild desaturation in the control group. CONCLUSIONS: BIS monitoring for diagnostic UGE in spontaneous breathing in a pediatric population is feasible, but does not appear to decrease awakening time or the amount of @entity1875 needed. Furthermore, there was no statistically significant decrease in the number of adverse effects.

title: [Usefulness of monitoring anaesthesia with the bispectral index in upper XXXX with spontaneous breathing].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Children', 'patient', 'PATIENTS']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal endoscopy']

answer: @entity344 :: (MESH:D005767,Disease) :: ['gastrointestinal endoscopies']