abstract: This paper presents the case of an 85-year-old male affected by classic @entity2826 (CKS) since 1994. The disease was widespread over much of the skin surface. Since 1995 the @entity1 had undergone several chemotherapy treatments with good, but not lasting results. Due to a worsening in the pathology, in October 2005 the @entity1 was prescribed a further cycle of vinorelbine. Twenty-four hours after the first infusion, followed by isotonic @entity2827 solution vein wash, a supra-venous serpentine @entity75 appeared directly above infusion site. The lesion extended centripetally from the injection point and involved the whole supra-venous area. Over the following days, a gradual variation in lesion colour, from erythematous to hyperpigmented, was observed. Given this clinical and histological picture, the diagnosis of persistent serpentine supra-venous hyperpigmented @entity203 (PSSHE) was made. Draft of a rare secondary effect whose pathogenesis still remain to explain. The literature holds reports of another skin manifestation with similar supra-venous characteristics: persistent supra-venous @entity203 (PSSE), clinical entity that enters in differential diagnosis with the PSSHE. Many of the drugs used in chemotherapy have been indicated as responsible for these peculiar side-effects. To the authors' knowledge, the literature reports only one PHSSE case induced by i.v. @entity1206 infusion.

title: Chemotherapy-induced persistent serpentine supra-venous hyperpigmented @entity203 and persistent supra-venous XXXX : case report.

entities_list: @entity2826 :: ('MESH:D012514', 'Disease') :: ["Kaposi's sarcoma"]

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['erythematous lesion']

entities_list: @entity203 :: ('MESH:D003875', 'Disease') :: ['erythematous eruption', 'eruption']

entities_list: @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine']

entities_list: @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']

answer: @entity203 :: (MESH:D003875,Disease) :: ['erythematous eruption']


abstract: @entity173 is more and more frequent in elderly population. For this reason, an increasing attention has been focused on the development of a non-invasive method to predict @entity2249 . A conventional approach to @entity174 diagnosis is the measurement of bone mass by dual-energy X-ray absorptiometry in some regions of interest. The aim of this work is to assess a method that accounts for the structural details of the bone providing a more direct determination of strength properties, and improving the diagnostic power of the current densitometric systems. A 2D finite element model of the proximal femur is derived from dual-energy X-ray absorptiometry data. Initially, the method is validated in vitro using a replica of the @entity1 femur. The predicted results are compared to strain-gauge measurements and to a 3D finite element model, with good agreement being observed. Then, an in vivo preliminary study on a limited group of @entity1 is carried out. The loading condition that simulates a fall to the side onto the greater trochanter from standing height is employed. All simulations show a peak strain at the femoral neck region with a strain distribution typical of a fall on the side. The proposed method seems to supply a useful tool for the in vivo analysis of the risk of @entity173 .

title: Risk of XXXX in elderly @entity1 : a new predictive index based on bone mineral density and finite element analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['Hip fracture', 'hip fracture']

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['femoral neck fracture']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: The combination of @entity3003 and @entity2879 is an active and well-tolerated regimen in the treatment of @entity151 ( @entity151 ). The aim of the study was to confirm whether the efficacy could be maintained if @entity2879 was administered orally. 106 consecutive, unselected, and untreated @entity1 with @entity151 ( @entity66 ( @entity66 ) 44; @entity66 ( @entity66 ) 62) were treated with a combination of @entity3003 300 mg/m2 intravenously (i.v.) day 1 and @entity2879 240 mg/m2 orally days 1-3 every 4 weeks for six courses or until progression. If oral treatment was inconvenient, i.v. @entity2879 (120 mg/m2 days 1-3) was allowed. @entity1514 irradiation (45 Gy in 22 fractions, split course) was given after three courses of chemotherapy to 29 @entity1 with @entity66 . Objective response (complete and partial) was seen in 89% (confidence interval (CI) 75-97) of @entity1 with @entity66 and in 53% (CI 40-66) with @entity66 . Complete response was seen in 41% (CI 26-57) of @entity1 with @entity66 and in 8% (CI 2-18) with @entity66 . Median time to progression for responders was 11 months and 6 months for @entity1 with @entity66 and @entity66 , respectively. Corresponding median survival was 15 months (range 1-45 months) and 8.5 months (0-26 months). Myelosuppression comprised the main @entity137 . @entity1210 (WHO III-IV) was observed in 20% and @entity882 (WHO III-IV) in 16% of the cases. One @entity1 died of @entity295 during @entity1210 . Oral treatment was convenient for most @entity1 and therapy well tolerated. However, 9 @entity1 (20%; CI 9-36%) with @entity66 and 26 @entity1 (42%; CI 29-56%) with @entity66 received at least part of the @entity2879 treatment i.v.. The present study shows that the combination of @entity3003 and oral @entity2879 is active and well tolerated, and may be used on an outpatient basis in @entity1 with @entity151 .

title: Is XXXX and oral @entity2879 an effective and feasible regimen in @entity1 with @entity151 ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['extensive disease', 'limited disease', 'LD', 'ED']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung cancer']

entities_list: @entity1210 :: ('MESH:C536227', 'Disease') :: ['leucopenia', 'Leucopenia']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: The distribution of @entity12217 ( @entity12217 ) and @entity20658 ( @entity20658 ) was investigated immunocytochemically in @entity35 at various time intervals after 10 min @entity2806 ( @entity2806 ) induced by @entity1167 . Strong @entity12217 and weaker @entity20658 immunoreactivity was found extracellularly in multiple deposits located close to the microvessels. These deposits appeared 3 h after @entity2806 and were present, but not in all the animals, at all time intervals studied post-GCL. In some @entity35 , @entity12217 immunoreactivity was also found in small @entity39 foci. Widespread, neuronal @entity12217 immunostaining appeared 6 h post- @entity2806 . However, the strongest neuronal @entity12217 immunoreactivity was found 7 days post- @entity2806 in those neurons, most often observed in the @entity1249 hippocampal region, exhibiting signs of @entity2806 . These ischemically damaged neurons displayed weaker immunoreactivity to @entity20658 , despite its increase in the response to @entity2806 in the various brain regions examined. Our data show that mechanisms operating in @entity63 are able to supply large amounts of @entity12217 and @entity20658 to the brain tissue and suggest involvement of both @entity12217 and @entity20658 in a complex series of events occurring in the @entity63 brain. Perivascular deposits of @entity12217 / @entity20658 colocalized with amyloid beta protein precursor epitopes that have been disclosed by us previously in this model. Whether this phenomenon is limited to postischemic brain tissue, or can be encountered also in other pathological conditions will require further elaboration.

title: Complete @entity2806 with short-term survival in XXXX induced by @entity1167 . II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain.

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['global cerebral ischemia', 'GCI', 'ischemic cell damage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES: To evaluate the role of ultra sound-guided systematic and lesion-directed biopsies, biopsy gleason score, preoperative serum @entity1486 as three objective and reproducible variables to provide a reliable combination in preoperative identification of risk of extraprostatic extension in @entity1 with clinically localized @entity263 . METHODS: The case records of 813 @entity1 who underwent radical prostatectomy for clinically localized @entity263 were analyzed. All had multiple systematic biopsies, two to three from each lobe, in addition to lesion-directed biopsies. Additionally, biopsies were done on seminal vesicles (SVs), if abnormal. Based on biopsy results, @entity1 were classified as having stage B1 (T2a-T2b) or B2 (T2c) disease, depending on whether biopsies from one or both lobes were positive and stage C (T3) if there was evidence of SV involvement by biopsy of biopsies from areas of extracapsular extension as seen on transrectal ultrasound (TRUS) were positive. Logistic regression analyses with log likelihood chi-square test was used to define the correlation between individual as well as combination of preoperative variables and pathologic stage. RESULTS: On final pathologic examination, 473 (58%) @entity1 had organ-confined disease, 188 (23%) had extracapsular extension (ECE), with or without positive surgical margins, and 72 (9%) had SV involvement. Eighty (10%) @entity1 had pelvic lymph node @entity3 . Biopsy-based staging was superior to clinical staging in predicting final pathologic diagnosis. Logistic regression analyses revealed that the combination of biopsy-based stage, preoperative serum @entity1486 , and biopsy Gleason score provided the best prediction of final pathologic stage. Probability plots constructed with these data can provide significant information on risk of extraprostatic extension in individual @entity1 . CONCLUSIONS: This study demonstrates that TRUS-guided systematic biopsy in combination with preoperative serum @entity1486 and biopsy Gleason score may provide a cost-effective approach for management decisions and prognostication in @entity1 with @entity263 .

title: The role of transrectal ultrasound-guided biopsy-based staging, preoperative serum XXXX , and biopsy Gleason score in prediction of final pathologic diagnosis in @entity263 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen (PSA)', 'PSA']

answer: @entity1486 :: (354,Gene) :: ['prostate-specific antigen']


abstract: Ecological engineering for pest management involves the identification of optimal forms of botanical diversity to incorporate into a farming system to suppress pests, by promoting their natural enemies. Whilst this approach has been extensively researched in many temperate crop systems, much less has been done for @entity579 . This paper reports the influence of various plant species on the performance of a key natural enemy of @entity579 planthopper pests, the predatory mirid bug, Cyrtorhinus lividipennis. Survival of adult males and females was increased by the presence of flowering Tagetes erecta, Trida procumbens, Emilia sonchifolia (Compositae), and @entity5420 (Pedaliaceae) compared with water or nil controls. All flower treatments resulted in increased consumption of brown plant hopper, Nilaparvata lugens, and for female C. lividipennis, @entity5420 was the most favorable. A separate study with a wider range of plant species and varying densities of prey eggs showed that @entity5420 most strongly promoted predation by C. lividipennis. Reflecting this, @entity5420 gave a relatively high rate of prey search and low prey handling time. On this basis, @entity5420 was selected for more detailed studies to check if its potential incorporation into the farming system would not inadvertently benefit @entity14870 and Marasmia patnalis, serious Lepidoptera pests of @entity579 . Adult longevity and fecundity of both pests was comparable for @entity5420 and water treatments and significantly lower than the honey solution treatment. Findings indicate that S. indicumis well suited for use as an ecological engineering plant in the margins of @entity579 crops. @entity5420 indicum can be a valuable crop as well as providing benefits to C. lividipennis whilst denying benefit to key pests.

title: Selection of Nectar Plants for Use in Ecological Engineering to Promote Biological Control of XXXX Pests by the Predatory Bug, Cyrtorhinus lividipennis, (Heteroptera: Miridae).

entities_list: @entity5420 :: ('4182', 'Species') :: ['Sesamum indicum', 'S. indicum', 'Sesame']

entities_list: @entity14870 :: ('437488', 'Species') :: ['Cnaphalocrocis medinalis']

answer: @entity579 :: (4530,Species) :: ['Rice']


abstract: This study describes a simple chromatographic method for the simultaneous analyses of @entity2434 (PC) and its hydrolytic degradation products: @entity6579 ( @entity15002 ) and free @entity1718 (FFA). Quantitative determination of PC, LPC, and FFA is essential in order to assure safety and to accurately assess the shelf life of phospholipid-containing products. A single-run normal-phase high-performance liquid chromatography (HPLC) with evaporative light scattering detector has been developed. The method utilizes an Allsphere silica analytical column and a gradient elution with mobile phases consisting of @entity3636 : @entity3636 - @entity1042 (70:30%, v/v) and @entity3636 - @entity1042 -water- @entity3265 (45:45:9.5:0.5%, v/v/v/v). The method adequately resolves PC, LPC, and FFA within a run time of 25 min. The quantitative analysis of PC and LPC has been achieved with external standard method. The free @entity1718 were analyzed as a group using @entity4722 as representative standard. Linear calibration curves were obtained for PC (1.64-16.3  g, r(2)   = 0.9991) and LPC (0.6-5.0  g, r(2)   = 0.9966), while a logarithmic calibration curve was obtained for @entity4722 (1.1-5.8  g, r(2)   = 0.9967). The detection and quantification limits of LPC and @entity6334 were 0.04 and 0.1  g, respectively. As a means of validating the applicability of the assay to pharmaceutical products, PC liposome was subjected to alkaline hydrolytic degradation. Quantitative HPLC analysis showed that 97% of the total mass balance for PC could be accounted for in liposome formulation. The overall results show that the HPLC method could be a useful tool for chromatographic analysis, stability studies, and formulation characterization of phospholipid-based pharmaceuticals.

title: Simple chromatographic method for simultaneous analyses of XXXX , @entity6579 , and free @entity1718 .

entities_list: @entity6579 :: ('MESH:D008244', 'Chemical') :: ['lysophosphatidylcholine']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform']

entities_list: @entity2434 :: ('MESH:D010713', 'Chemical') :: ['phosphatidylcholine']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']

answer: @entity2434 :: (MESH:D010713,Chemical) :: ['phosphatidylcholine']


abstract: Some @entity272 may accompany @entity5 . @entity3594 , one such lesion, is a @entity272 characterized by hyperpigmented and velvety verrucose plaques observed as symetric eruptions. With this report, we aim to present a rare case of concomitant @entity2 and acanthosis nigricans. @entity5 is most commonly associated with intra-abdominal @entity5 . A 65-year-old @entity1 who had hyperpigmented, @entity1184 and @entity75 at the flexor surfaces of the lower and upper extremities, face, palms and the axillary region. Thoracic computed tomography demonstrated a hypodense @entity66 with a dimension of 5 x 5.5 cm at the center of basal segment bronchi of the @entity358 . Fiberoptic bronchoscopy showed that the access to the lower left lobe was almost completely obstructed by the endobronchial lesion. The result of the histopathologic examination of the endobronchial tissue biopsy was reported as non-small cell ( @entity420 ) @entity2 . Result of the histopathologic analysis of the punch biopsy of the @entity272 was reported as acanthosis nigricans .There are no pathognomonic dermatological findings for @entity2 . In conclusion, there are @entity272 that accompany @entity2 and we believe that these should be considered for differential diagnosis.

title: @entity3594 in a @entity1 with XXXX : a case report.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['mass lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'Malignant acanthosis nigricans']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['symmetric verrucose lesions']

entities_list: @entity3594 :: ('MESH:D000052', 'Disease') :: ['Acanthosis nigricans']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['left pulmonary lobe']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions', 'paraneoplastic dermatosis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: @entity978 is a folliculitic and perifolliculitic dermatophyte @entity281 of the dermis, a site that is not generally colonized by fungi in immunocompetent individuals. Topical agents are usually ineffective therapeutically because of the deep location of the @entity281 . The objective of this study was to determine the effectiveness of oral @entity2059 . We also examined the pharmacokinetics of the drug in scalp hair during pulse therapy. This information would then be useful in determining the efficacy of @entity2059 administered by means of intermittent pulse dosing in the treatment of @entity3100 . Seven @entity1 (age range 25-75 years) were treated up to three times with @entity2059 pulse therapy, 200 mg twice daily for 1 week, with 2 weeks off between pulses. Samples of scalp hair and plasma were also obtained to determine the pharmacokinetics of the drug at these two sites. All seven @entity1 responded to therapy, clinical and mycological cure being achieved after one pulse (one @entity1 ), two pulses (three @entity1 ), or three pulses (three @entity1 , each with @entity6313 ); none relapsed over a 6-18-month follow-up period. In all six @entity1 who received two or more pulses of @entity2059 , almost complete cure was observed before the second pulse, with full resolution within 2 weeks of its completion. @entity2059 was also detected in the hair after 1 week, and at concentrations 2.6-fold and 3.4-fold higher, respectively, after the second and third pulses. After the discontinuation of therapy, @entity2059 was then detectable in the hair for 9 months, at least in a female @entity1 who did not have her hair cut. Two pulses of oral @entity2059 therapy thus appear to be effective in the treatment of @entity978 , and it is possible that one pulse may be sufficient in some @entity1 . These data suggest that @entity2059 pulse therapy should be effective in the treatment of @entity3100 .

title: XXXX pulse therapy is effective in the treatment of @entity978 : a clinical and pharmacokinetic evaluation and implications for possible effectiveness in @entity3100 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6313 :: ('MESH:D014009', 'Disease') :: ['toenail onychomycosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity3100 :: ('MESH:D014006', 'Disease') :: ['tinea capitis']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Majocchi's granuloma"]

entities_list: @entity2059 :: ('MESH:D017964', 'Chemical') :: ['Itraconazole', 'itraconazole']

answer: @entity2059 :: (MESH:D017964,Chemical) :: ['Itraconazole']


abstract: BACKGROUND: Little is known regarding the factors associated with the times for @entity1 ' first physician visit, the first physician suspicion of work-related @entity565 (WRA), and final diagnosis after the onset of WRA symptoms. This study examined individual and work-related factors that are associated with longer times to these diagnostic milestones among groups with @entity7446 ( @entity7446 ) and work-exacerbated @entity565 (WEA). METHOD: Suspected WRA cases were identified from an @entity358 clinic and claimants to the Ontario Workplace Safety and Insurance Board (100 @entity1 each). Questionnaire administration and chart review were undertaken. RESULTS: Eighty @entity1 were classified as having sensitizer-induced @entity7446 and 87 as having WEA. For the @entity7446 group, the risk factors for delay included male sex, being unmarried, low education, and lack of awareness of association of symptoms with work. Other factors included older age, being the sole income earner, and lack of knowledge of the Workplace Hazardous Materials Information System program. For WEA, lower household income, lower education, absence of a health-and-safety program at work, absence of a union, and lack of awareness of @entity7446 and of agents at work that could affect @entity565 significantly increased the time to diagnostic milestones. CONCLUSIONS: Different factors affect the diagnostic milestones for @entity7446 and WEA. Findings suggest a need for educational programs for workers who are at risk of @entity7446 and WEA and a need for further primary care physician education on WRA.

title: Occupational @entity565 and work-exacerbated XXXX : factors associated with time to diagnostic steps.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity7446 :: ('MESH:D059366', 'Disease') :: ['OA', 'occupational asthma']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['occupational lung disease']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: The purpose of this study was to assess the feasibility to determine fetal blood @entity26 saturation @entity9734 with T(2)-weighted MR sequences using a fetal @entity742 model. T(2) measurements were performed on a 1.5-T scanner using a T(2) preparation pulse in combination with a three-dimensional balanced steady-state free precession sequence repeated at different echo times. Eight @entity742 fetuses were examined during a control, @entity519 , and recovery phase to perform T(2)-weighted scans of the fetal blood in the heart. Signal intensities in the left and right ventricle were measured to calculate the MR blood sO(2). During each phase, fetal carotid artery sO(2) was directly measured and correlated with MR sO(2). A Bland-Altman plot was performed. Fetal carotid artery sO(2) was 69% sO(2) during control, 16% sO(2) during @entity519 , and 67% sO(2) during recovery. Mean values of the MR sO(2) were 49% sO(2) and 40% sO(2) for control, 6% s @entity3612 and 3% sO(2) for @entity519 , and 51% sO(2) and 43% sO(2) for recovery in left ventricle and right ventricle, respectively. Mean values of fetal carotid artery sO(2) and MR sO(2) were highly correlated (left ventricle: r = 0.87, right ventricle: r = 0.89). According to the Bland-Altman plot, MR sO(2) was lower compared to fetal carotid artery s @entity3612 (left ventricle: 15%, right ventricle: 20%). Based on our preliminary results, it seems to be possible to assess fetal sO(2) with MR oximetry.

title: In vivo MRI measurement of fetal blood @entity26 saturation in cardiac ventricles of fetal XXXX : a feasibility study.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia', 'hypoxic']

answer: @entity742 :: (9940,Species) :: ['sheep']


abstract: Interphase fluorescent in situ hybridization on unstimulated peripheral blood mononuclear cells (I-FISH-PBMC) is used to detect @entity2008 such as 11q-, 13q-, 17p-, and trisomy 12 in @entity1072 ( @entity1072 ). A total of 56 samples from 49 @entity1 with @entity1072 were studied using commercially available probes for chromosome regions 11q22.3 (ATM), 13q14 (13S272), 17p13 ( @entity876 ) and 12 centromere (D12Z3). We compared the results obtained with I-FISH-PBMC and those with I-FISH on @entity865 ( @entity4514 ; @entity1359 ) stimulated peripheral blood cells (I-FISH- @entity865 ) used for conventional cytogenetics, to evaluate the usefulness of I-FISH- @entity865 . The proportion of abnormal nuclei obtained with the I-FISH- @entity865 was higher than that found with I-FISH-PBMC (P < 0.001). Consequently, 15 cases with a negative or borderline result with I-FISH-PBMC became positive with I-FISH- @entity865 for 11q- (n = 2), 13q- (n = 9), and trisomy 12 (n = 4). In all but one of these, @entity2008 were confirmed by either metaphase FISH or conventional G-banding. Detection of cytogenetic aberrations thus increased from 51% with I-FISH-PBMC to 78% with I-FISH- @entity865 . Notably, all 15 of the cases that reached the diagnostic thresholds for 11q-, 13q-, and trisomy 12 had a slight lymphocytosis. An absolute lymphocyte count <8.7 x 10(9)/L was found to be the critical threshold (P = 0.037) below which I-FISH- @entity865 rather than I-FISH-PBMC should be performed. Not only could I-FISH- @entity865 detect a higher proportion of abnormal interphase nuclei, but it could also identify abnormal @entity1072 cases that might be overlooked with use of I-FISH-PBMC, especially those with low absolute lymphocyte counts. I-FISH- @entity865 is thus a reliable technique for clinical diagnostics in @entity1072 .

title: Detection of chromosomal XXXX increased by interphase fluorescence in situ hybridization in @entity4514 -stimulated peripheral blood cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'chronic lymphocytic leukemia']

entities_list: @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol-12-myristate-13-acetate']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities']

entities_list: @entity4514 :: ('MESH:D013755', 'Chemical') :: ['tetradecanoylphorbol acetate']

answer: @entity1072 :: (MESH:D015451,Disease) :: ['abnormalities in chronic lymphocytic leukemia']


abstract: OBJECTIVES: To summarize and critically evaluate the evidence available from clinical trials (CTs) of qigong for @entity1 with @entity164 2 @entity6 . METHODS: We have searched the literature using 15 databases from their respective inceptions through March 2009 without language restrictions. Risk of bias was assessed using Cochrane criteria. RESULTS: Nine CTs, which included three @entity922 ( @entity922 ), one @entity922 ( @entity922 ) and five uncontrolled observational studies (UOSs), met our inclusion criteria. Three @entity922 compared qigong plus usual care (including drug therapy) with usual care alone. The quality of these @entity922 was poor. Their results suggested favorable effects of qigong on glycosylated hemoglobin (HbA1c), 2h plasma @entity413 (2hPG), insulin sensitivity, and blood viscosity. One @entity922 compared qigong with no treatment and failed to show favorable effects of qigong on fasting plasma @entity413 (FPG), 2hPG, HbA1c and insulin sensitivity. All UOSs reported beneficial effects of qigong on FPG or 2hPG. CONCLUSION: Currently there are few rigorous trials testing the effectiveness of qigong for @entity164 2 @entity6 . The studies that are available are of low methodological quality. Collectively this evidence is insufficient to suggest that qigong is an effective treatment for @entity164 2 @entity6 . Rigorously designed trials are warranted to answer the many questions that remain open.

title: Qigong for XXXX 2 @entity6 care: a systematic review.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['randomized clinical trials', 'RCTs', 'controlled clinical trial', 'CCT']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: Many anxiolytics, anticonvulsants and general anesthetics modulate @entity1246 type A (GABAA) receptors. The anxiolytic @entity1245 potentiate the actions of @entity1246 , and this only at GABAA receptors with gamma subunits. The general anesthetics both potentiate @entity1246 and activate GABAA receptors directly, but their binding sites on the receptor are poorly defined. We examined whether the @entity22473 subunit was required for the modulation of GABAA receptors by the general anesthetic @entity1875 ( @entity1875 ). Using the patch-clamp technique, we recorded membrane currents from HEK293 cells transfected with @entity1 @entity23074 cDNAs and with alpha 2 and @entity8652 cDNAs alone. Both forms of the receptor were activated by @entity1246 and by @entity1875 at low concentrations. At maximal doses, @entity1875 was considerably less effective than @entity1246 as an activator of alpha 2 @entity8652 GABAA receptors, but it had an efficacy similar to that of @entity1246 as an activator of alpha 2 @entity8652 gamma 2s receptors. In addition to activating currents directly, @entity1875 potentiated currents elicited by @entity1246 recorded from cells expressing either subunit combination. We conclude that the @entity22473 subunit is not a prerequisite for activation of GABAA receptors by @entity1875 or for its potentiation of @entity1246 -activated currents. However, the subunit may contribute to the efficacy of @entity1875 as a GABAA receptor activator.

title: Modulation of the GABAA receptor by XXXX is independent of the gamma subunit.

entities_list: @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['2,6-diisopropylphenol', 'propofol']

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['propofol']


abstract: BACKGROUND: Although clinicians commonly use computed tomography or ultrasonography to diagnose @entity697 , the accuracy of these imaging tests remains unclear. PURPOSE: To review the diagnostic accuracy of computed tomography and ultrasonography in adults and adolescents with suspected @entity697 . DATA SOURCES: The authors used MEDLINE, EMBASE, bibliographies, review articles, textbooks, and expert opinion to retrieve English- and non-English-language articles published from 1966 to December 2003. STUDY SELECTION: The authors included prospective studies evaluating computed tomography or ultrasonography followed by surgical confirmation or clinical follow-up in @entity1 at least 14 years of age with suspected @entity698 . DATA EXTRACTION: One assessor (for non-English-language studies) or 2 assessors (for English-language studies) independently reviewed each article to abstract relevant study characteristics and results. DATA SYNTHESIS: Twelve computed tomography studies and 14 ultrasonography studies met inclusion criteria. Computed tomography had an overall sensitivity of 0.94 (95% CI, 0.91 to 0.95), a specificity of 0.95 (CI, 0.93 to 0.96), a positive likelihood ratio of 13.3 (CI, 9.9 to 17.9), and a negative likelihood ratio of 0.09 (CI, 0.07 to 0.12). Ultrasonography had an overall sensitivity of 0.86 (CI, 0.83 to 0.88), a specificity of 0.81 (CI, 0.78 to 0.84), a positive likelihood ratio of 5.8 (CI, 3.5 to 9.5), and a negative likelihood ratio of 0.19 (CI, 0.13 to 0.27). Verification bias and inappropriate blinding of reference standards were noted in all of the included studies. LIMITATIONS: The summary assessment of the diagnostic accuracy for both tests was limited by the small number of studies, heterogeneity among study samples, and poor methodologic quality in the original studies. CONCLUSIONS: Computed tomography is probably more accurate than ultrasonography for diagnosing @entity698 in adults and adolescents. Prospective studies that apply gold standard diagnostic testing to all study @entity1 would more reliably estimate the true diagnostic accuracy of these tests.

title: Systematic review: computed tomography and ultrasonography to detect XXXX in adults and adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'participants']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['appendicitis']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute appendicitis']


abstract: This study investigates the metabolism of the divalent cation, @entity1760 ( @entity1025 ) in the isolated perfused Langendorff's @entity35 heart and @entity67 in the absence and presence of @entity2661 including @entity3044 , @entity1063 and @entity1425 . Perfusion of the isolated @entity35 heart with a physiological salt solution containing elevated extracellular @entity1025 [ @entity1025 ]o (2.4 mM-6.0 mM) resulted in a marked and progressive decrease in the amplitude of contraction compared to control [ @entity1025 ]o (1.2 mM). In contrast, perfusion of hearts with low (0-0.6 mM) [ @entity1025 ]o caused a small transient increase in the amplitude of contraction which was often accompanied by arrhythmic activity. Perfusion of the heart with a nominally @entity1025 free medium resulted in a time-dependent net efflux of @entity1025 reaching a steady state after approximately 40-50 min of perfusion. This release of @entity1025 was associated with a concurrent decrease in total heart @entity1025 . Stimulation of the heart with the beta adrenergic agonist, @entity3044 (10(-7) M) caused large increases in net @entity1025 efflux which was associated with marked increased in both rate and the amplitude of contraction. Similar effects on @entity1025 efflux were also observed during perfusion of the heart with the adenylate cyclase activator, @entity1928 (10(-5) M). Superfusion of paced ventricular segments with either @entity3044 , @entity1425 or @entity1063 (all 10(-6) M) also resulted in a marked transient net efflux of @entity1025 . Pre-treatment of segments with the beta adrenergic antagonist, @entity1169 (10(-5) M) competitively blocked the @entity1025 efflux evoked by the @entity2661 . Similarly, pre-treatment of segments with the @entity460 ( @entity141 ) channel blocker, @entity1855 (10(-5) M) caused a significant (P < 0.05) decrease in net @entity1025 efflux evoked by @entity3044 . The results of this study indicate that (1) the perturbation of [ @entity1025 ]o has an important influence on myocardial contractility and (2) the mobilization of @entity1025 in the heart is associated with beta adrenergic stimulation possibly via an elevation in intracellular @entity268 ( @entity1919 ).

title: Effects of extracellular @entity1760 and beta adrenergic stimulation on contractile force and @entity1760 mobilization in the isolated XXXX heart.

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity268 :: ('CHEBI:17489', 'Chemical') :: ['adenosine 3.5 cyclic monophosphate']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular slices']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline']

entities_list: @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: Whether rescue surgery confers a survival benefit in @entity1 undergoing non-curative endoscopic resection of early @entity356 remains controversial. METHODS: This was a retrospective review of @entity1 who underwent non-curative endoscopic resection of at least one lesion of differentiated-type early @entity356 between 2000 and 2011. @entity1 with a positive lateral resection margin as the only non-curative factor were excluded. Outcome was investigated by univariable (Kaplan-Meier) and multivariable (Cox proportional hazards) analysis. RESULTS: Some 341 @entity1 underwent non-curative endoscopic resection for at least one lesion of differentiated-type early @entity356 . Sixty-seven @entity1 with a positive lateral resection margin as the only non-curative factor were excluded, leaving 274 @entity1 for analysis; 194 had rescue surgery and 80 had no additional treatment. The median duration of follow-up was 60  5   months. @entity1 who had rescue surgery were younger, had a lower Charlson co-morbidity index score, smaller @entity5 and a higher lymphovascular invasion rate than @entity1 with no treatment. Among 194 @entity1 who had rescue surgery, intragastric @entity5 were found in ten (5  2 per cent) and lymph node @entity3 in 11 (5  7 per cent). @entity1 with @entity1600 were significantly older than those without @entity3 ; no other significant differences were found. Univariable analysis showed that @entity1 aged less than 65 years, those with a Charlson co-morbidity index score below 4 and @entity1 undergoing rescue surgery had significantly longer overall survival. Five-year overall survival rates in the rescue surgery and no-treatment groups were 94  3 and 85 per cent respectively. In multivariable analysis, rescue surgery was identified as the only independent predictor of overall survival after non-curative endoscopic resection of early @entity356 . CONCLUSION: Rescue surgery confers a survival benefit after non-curative endoscopic resection of early @entity356 .

title: Effect of rescue surgery after non-curative endoscopic resection of early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['local residual tumours', 'tumours']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: Previously we showed that @entity6708 hydrolysis in @entity35 whole retinal homogenates exhibited a dose-dependent inhibition following developmental lead exposure and a concentration-dependent inhibition with direct @entity10781 exposure. Additionally, developmental lead exposure resulted in a dose-dependent increase in retinal @entity6708 and rod @entity141 levels. To determine whether @entity10781 or @entity141 directly inhibited the rod-specific @entity6708 phosphodiesterase (PDE) and to examine the kinetic mechanism of this inhibition, purified @entity291 rod @entity6708 PDE was assayed in the presence of varying concentrations of @entity6708 , and @entity1025 , @entity10781 , and/or @entity141 . Increasing concentrations of the substrate, @entity6708 , resulted in a shift of the @entity10781 and @entity141 concentration-response curves to the left, indicating a decrease in the half-maximal inhibitory concentrations of @entity10781 from nanomolar to picomolar levels. Increasing concentrations of the cofactor, @entity1025 , resulted in a shift of the @entity10781 and @entity141 concentration-response curves to the right, indicating a decrease in the inhibition of PDE activity by @entity10781 or @entity141 . A plot of 1/velocity vs 1/ @entity1025 as a function of @entity10781 revealed that picomolar concentrations of @entity10781 competitively inhibited PDE relative to millimolar concentrations of @entity1025 . Consistent with this finding, @entity1025 reversed the @entity10781 -induced inhibition of PDE. Our recent kinetic analysis showed that @entity1025 and @entity6708 bind at interacting sites on the PDE in a random order. The present results reveal that @entity10781 may bind at the same site but with 4-6 log units higher affinity than @entity1025 , thus preventing the hydrolysis of @entity6708 . These findings provide a novel mechanism for understanding the @entity10781 -induced inhibition of @entity6708 PDE. These results may have implications for other enzymes using @entity1025 as a cofactor and suggest that @entity1025 may be useful in these situations for reversing the inhibition by @entity10781 .

title: Lead- and calcium-mediated inhibition of XXXX rod @entity6708 phosphodiesterase: interactions with magnesium.

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: BACKGROUND: Posttransplant @entity786 has been shown to control @entity2132 and facilitate engraftment in the major histocompatibility complex-haploidentical transplant setting. Here, we hypothesized that @entity1499 ( @entity6822 ) could be used in a similar fashion. In @entity1 with @entity74 , the use of @entity6822 rather than an alkylating agent such as @entity786 would be preferable due to its reduced risk of promoting secondary @entity5 . METHOD: Using our standard conditioning regimen consisting of a specific anti- @entity22090 mAb (S5) and 200 cGy total body irradiation followed by postgrafting immunosuppression with @entity205 and @entity618 as a control group, we compared outcomes with experimental animals receiving the same regimen with the addition of a single, large dose of posttransplant @entity6822 on day +3 (50-400 mg/m2). RESULTS: Adding @entity6822 at all dose levels did not abrogate initial engraftment and controlled @entity2132 in most cases. @entity235 receiving @entity6822 at the first dose level (50 mg/m2) improved time to rejection compared with controls (P=0.03) but did not decrease overall rates of rejection (P=0.56). However, increasing the dose of @entity6822 beyond 50 mg/m2 seemed to have detrimental effects in both average (P=0.04) and peak (P=0.002) donor chimerism. Increasing the dose of @entity6822 also promoted more profound @entity2905 . Finally, delaying @entity205 and @entity618 until after @entity6822 administration did not seem to significantly improve engraftment kinetics. CONCLUSION: Adding high-dose @entity6822 seemed to benefit the duration of donor chimerism at the lowest dose studied, but there was no benefit when escalating @entity6822 doses to @entity137 .

title: Evaluation of posttransplant @entity1499 to facilitate engraftment in the XXXX major histocompatibility complex-haploidentical nonmyeloablative transplant model.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphopenia']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['graft-versus-host disease']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic diseases']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity235 :: (9615,Species) :: ['canine']


abstract: Biomaterials in the peritoneal cavity disrupt the physiology of the host and may cause bacterial translocation. The current study was performed to determine whether biomaterials exacerbate @entity1320 . Adult male @entity35 were divided into four groups: group 1, celiotomy+intraperitoneal (i.p.) saline; group 2, celiotomy+i.p. @entity526 (3 x 10(8) cfu); group 3, i.p. rubber+i.p. saline; and group 4, i.p. rubber+i.p. @entity526 (3 x 10(8) cfu). Twelve h after the challenge, enteric bacterial translocation, bacterial population levels in the cecum and serum levels of @entity568 and @entity1505 were measured. Bacterial translocation to mesenteric lymph nodes and the liver was observed in animals from groups 2 and 3, but significantly increased in group 4 with a concomitant elevation of serum levels of @entity1505 and @entity568 , as compared with group 1. Histological examination revealed a more pronounced inflammatory reaction in the peritoneum and distal ileum in group 4 than in groups 2 and 3. These results suggest that the presence of rubbers in the peritoneal cavity aggravates @entity1320 .

title: Abdominal rubber drain piece aggravates XXXX in the @entity35 .

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal sepsis', 'intra-abdominal infections']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity1320 :: (MESH:D059413,Disease) :: ['intra-abdominal sepsis']


abstract: Recent in vitro and ex vivo studies disclosed an enhancement of the activity of antimicrobials on multidrug-resistant @entity796 by n-6 @entity1474 ( @entity5204 ); therefore their effect was evaluated in experimental @entity295 in 60 @entity95 . Solutions of @entity18943 ( @entity9984 ) and @entity1426 (AA) were administered intravenously with @entity5505 and @entity4509 in @entity95 with @entity295 caused by one multidrug-resistant isolate. Therapy was started after bacterial challenge in five groups comprising 12 animals in each group: A, normal saline; B, antimicrobials; C, 99% @entity1068 and antimicrobials; D, @entity9984 and antimicrobials; and E, AA and antimicrobials. Blood was sampled for the estimation of levels of endotoxins in serum (lipopolysaccharide), leukocytes, @entity5 necrosis factor alpha (TNF-alpha) and antimicrobials. Animals were sacrificed 210 min after bacterial challenge for tissue cultures. All animals had considerable @entity5694 and evolved @entity1431 . The number of viable cells in blood, lung, and mesenteric lymph nodes was significantly reduced in groups D and E compared to that in other groups. Levels of antimicrobials in serum were inadequate to achieve @entity2348 due to the level of resistance. n-6 @entity5204 did not influence TNF-alpha. It is concluded that intravenous coadministration of n-6 @entity5204 and antimicrobials enhanced antimicrobial @entity2348 in experimental @entity295 caused by multidrug-resistant @entity796 .

title: n-6 XXXX enhance the activities of @entity5505 and @entity4509 in experimental @entity295 caused by multidrug-resistant @entity796 .

entities_list: @entity5204 :: ('CHEBI:26208', 'Chemical') :: ['PUFAs', 'PUFAS']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa']

entities_list: @entity5694 :: ('MESH:D019446', 'Disease') :: ['endotoxemia']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids']

entities_list: @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial killing']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity18943 :: ('MESH:D017965', 'Chemical') :: ['gamma-linolenic acid']

entities_list: @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime']

answer: @entity1474 :: (MESH:D005231,Chemical) :: ['polyunsaturated fatty acids']


abstract: We recently observed that @entity4341 pretreatment significantly enhanced the @entity1188 size (IS)-limiting effect of preconditioning (PC), which was attenuated by @entity859 receptor antagonist. This potentiation of PC was interpreted to result from inhibition of @entity2353 transport by @entity4341 , but contribution of other pharmacologic actions of @entity4341 could not be excluded. To confirm that inhibition of @entity2353 transport leads to PC enhancement, we assessed alteration of mild PC by two different @entity2353 transport inhibitors, dilazep and @entity10967 , which, unlike @entity4341 , lack action on phosphodiesterase (PDE) and @entity4770 . @entity583 was induced in @entity95 by 30-min @entity1563 and 72-h reperfusion. IS and area at risk (AAR) were determined by histology and fluorescent particles, respectively. @entity95 either were untreated or received dilazep (0.34 mg/kg intravenously, i.v.) or @entity10967 (0.05 mg/kg i.v.) before @entity1563 . In other groups of @entity95 , PC was conducted with 2-min @entity63 and 5-min reperfusion with or without injection of the @entity2353 transport inhibitor (0.34 or 0.10 mg/kg dilazep or 0.05 mg/kg of @entity10967 ) before PC. IS expressed as percentage of AAR (%IS/AAR) was 43.9 +/- 2.3% (SE) in untreated controls; dilazep (0.34 mg/kg) and @entity10967 alone did not modify IS (%IS/AAR = 50.6 +/- 4.7 and 42.7 +/- 11.9%, respectively). PC tended to reduce IS (%IS/AAR = 33.3 +/- 3.5%), but the combination of dilazep or @entity10967 with PC significantly limited %IS/AAR (%IS/AAR = 22.5 +/- 5.0% after low-dose dilazep plus PC, 27.6 +/- 4.9% after high-dose dilazep plus PC, and 19.9 +/- 3.6%, after @entity10967 plus PC).(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity2353 transport inhibitors enhance the @entity1188 size-limiting effect of XXXX preconditioning.

entities_list: @entity2353 :: ('CHEBI:33838', 'Chemical') :: ['nucleoside']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusion']

entities_list: @entity95 :: ('9986', 'Species') :: ['Rabbits', 'rabbits']

entities_list: @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole']

entities_list: @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial infarction']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemic']


abstract: OBJECTIVE: To explore the feasibility of      F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in proposing selection criteria for @entity1 with @entity157 ( @entity157 ) in liver transplantation. METHODS: We respectively analyzed 31 cases of @entity157 @entity1 from our hospital and those accepting no anti- @entity5 therapy or orthotopic liver transplantation before      F-FDG PET/CT examination. The T/B value was set as a semi-quantitative parameter reflecting the metabolic activities of @entity5 . And receiver operating characteristic (ROC) curve was plotted to determine the optimal cutoff value of T/B affecting @entity157 recurrence after transplantation. Their clinicopathological features were analyzed by univariate and multivariate analyses to determine the risk factors for @entity157 recurrence after transplantation. RESULTS: During the follow-up period, the total incidence of @entity5 recurrence or @entity3 was 51.6%. And the disease-free survival rates of 6 months, 1 year and 2 years post-transplantation were 93.5%, 67.7% and 46.8% respectively. The univariate analysis revealed 4 variables of affecting the recurrence or @entity3 of @entity157 after transplantation, namely T/B value, @entity5 size, @entity5 number and preoperative @entity160 ( @entity160 ) level. While multivariate analyses indicated that T/B value and @entity5 size were independent factors. CONCLUSION: T/B value, @entity5 number and preoperative @entity160 level were independent risk factors for @entity5 recurrence. As a prognostic indicator of @entity5 biological behavior,      F-FDG PET/CT can identify the eligible transplant @entity157 candidates.

title: [Feasibility study of      F-fluorodeoxyglucose positron emission tomography/computed tomography in proposing selection criteria for XXXX with @entity157 in liver transplantation].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity160 :: ('174', 'Gene') :: ['alpha fetoprotein', 'AFP']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity1 low-density lipoprotein (LDL) is a major @entity165 carrier in blood. Elevated concentration of low-density lipoprotein, especially when oxidized, is a risk factor for @entity731 and other cardiac inflammatory diseases. Past research has connected free radical initiated oxidations of LDL with the formation of @entity731 and plaque in the arterial wall. The role of LDL protein in the associated diseases is still poorly understood, partially due to a lack of structural information. In this study, LDL was oxidized by @entity3787 radical. The oxidized protein was then delipidated and subjected to trypsin digestion. Peptides derived from trypsin digestion were analyzed by liquid chromatography-tandem mass spectrometry (LC- @entity15 / @entity15 ). Identification of modified peptide sequences was achieved by a database search against @entity755 protein sequences using the SEQUEST algorithm. At different @entity3787 radical concentrations, oxidation products of @entity669 , @entity2340 , @entity815 , @entity1521 , and @entity376 were identified. Oxidized @entity535 residues are likely located on the exterior of the LDL particle in contact with the aqueous environment or directly bound to the free radical permeable lipid layer. These modifications provided insight for understanding the native conformation of @entity755 in LDL particles. The presence of some natural variants at the protein level was also confirmed in our study.

title: Mapping oxidations of @entity755 in XXXX low-density lipoprotein by liquid chromatography-tandem mass spectrometry.

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity3787 :: ('MESH:D017665', 'Chemical') :: ['hydroxyl']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'atherosclerotic lesions']

entities_list: @entity815 :: ('CHEBI:28044', 'Chemical') :: ['phenylalanine']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Deep brain stimulation (DBS) of the internal globus pallidus (GPi) and ventral intermediate thalamic nucleus ( @entity2277 ) are established treatment options in primary @entity3519 and @entity400 syndromes and have been reported anecdotally to be efficacious in @entity2474 ( @entity2474 ). We investigated short- and long-term effects on motor function, cognition, affective state, and quality of life (QoL) of GPi- and @entity2277 -DBS in @entity2474 . Ten @entity2474 - @entity1 (nine epsilon-sarcoglycan-mutation-positive) were evaluated pre- and post-surgically following continuous bilateral GPi- and @entity2277 -DBS at four time points: presurgical, 6, 12, and as a last follow-up at a mean of 62.3 months postsurgically, and in OFF-, GPi-, @entity2277 -, and GPi- @entity2277 -DBS conditions by validated motor [unified @entity2045 rating scale (UMRS), TSUI Score, Burke-Fahn-Marsden @entity3519 rating scale (BFMDRS)], cognitive, affective, and QoL-scores. @entity2474 -symptoms significantly improved at 6 months post-surgery (UMRS: 61.5%, TSUI Score: 36.5%, BFMDRS: 47.3%). Beneficial effects were sustained at long-term evaluation post-surgery (UMRS: 65.5%, TSUI Score: 35.1%, BFMDRS: 48.2%). QoL was significantly ameliorated; affective status and cognition remained unchanged postsurgically irrespective of the stimulation conditions. No serious long-lasting stimulation-related adverse events (AEs) were observed. Both GPi- and @entity2277 -DBS offer equally effective and safe treatment options for @entity2474 . With respect to fewer adverse, stimulation-induced events of GPi-DBS in comparison with @entity2277 -DBS, GPi-DBS seems to be preferable. Combined GPi- @entity2277 -DBS can be useful in cases of incapaciting @entity2045 , refractory to GPi-DBS alone.

title: Pallidal and thalamic deep brain stimulation in XXXX .

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonus']

entities_list: @entity2474 :: ('MESH:C536096', 'Disease') :: ['myoclonus-dystonia', 'MD']

answer: @entity2474 :: (MESH:C536096,Disease) :: ['myoclonus-dystonia']


abstract: OBJECTIVES: To investigate the use of the digital @entity8907 (DP) system to collect data in a clinical trial. To assess the accuracy of the system in this setting. DESIGN: Qualitative study based on semistructured interviews and a focus group. Quantitative study comparing the DP system and a double manual data-entry system in accuracy of acquiring data by variable type (tick boxes, dates, numbers, letters). SETTING: An ongoing randomised multicentric clinical trial in tertiary care in France. @entity1 : 27 investigators involved in the trial (anaesthetists) who did or did not include @entity1 , 4 study monitors and the study coordinator. RESULTS: Six key findings emerged: 1) the DP system was easy to use; its utilisation was intuitive, even for investigators inexperienced in informatics; 2) despite its portability, the DP was not always used in front of @entity1 ; 3) the DP system did not affect @entity1 recruitment; 4) most of the technical problems of the system occurred during setup (compatibility, password access, antivirus software); 5) the main advantage was quickness of data availability for the study coordination staff and the main hindrance was the extra time required for online verification; and 6) all investigators were ready to use the system again. The investigators had to check 16% of data obtained by the DP system during the verification step. There is no relevant difference between the number of errors for the DP and the double manual data-entry systems: 8/5022 versus 6/5022 data entries. 5 out of 8 DP-system failures were due to the intelligent character recognition system. CONCLUSION: The DP system has a good acceptability among all investigators in a clinical setting, whether they are experienced with computers or not, and a good accuracy, as compared with double manual data entry.

title: Data capture by digital XXXX in clinical trials: a qualitative and quantitative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'patients', 'patient']

answer: @entity8907 :: (340348,Gene) :: ['pen']


abstract: Response rates to various drug regimens are determined in multi-center trials by radiographic measurement of @entity5 dimensions before and after treatment. The way in which lesions are measured may affect the reported results. Lesions due to primary @entity2 may be more difficult to assess than rounded peripheral metastases. No previous study has assessed the variability of @entity5 measurements in @entity1 with primary @entity2 . Nineteen radiographs from 12 @entity1 with @entity1149 ( @entity1149 ) were shown to 25 experienced readers on two separate occasions. Pre- and post-treatment (combined chemotherapy and radiotherapy) radiographs were first shown separately, unidentified and in random order. Three months later, they were shown side by side with the facility for comparison. A decrease in @entity5 size of greater than or equal to 50% was considered as a "response." Viewing paired films together increased the viewers ability to measure @entity5 compared with reading each film of the radiographic pair individually. Fifty-one percent of unmeasurable pairs became measurable when read together, whereas 13% of previously measurable pairs now became unmeasurable. The interobserver variation in measurements was 10% to 265%, while the intraobserver variation was 4% to 10%. The correlation between responses calculated on the first and second readings often was no better than chance alone. Subjective impressions of degree of improvement showed no good correlation with response rates measured objectively. Because of the large variation in measurements and consequently in response rate, we recommend that all radiographs be reviewed by a single observer for any particular study, and pre- and post-treatment radiographs be evaluated together.

title: Measurability of XXXX on chest radiographs.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']


abstract: PURPOSE: - To assess the association between @entity835 consumption and sport practice. METHODS: We randomised a representative sample of 1,506 @entity1 and 1,420 @entity1 from the third to the last year of school in the French Midi-Pyr  n  es region, excluding classes reserved for @entity1 practising high level sport. Information was collected by self-answer questionnaire. RESULTS: More than 90% of @entity1 and 70% of @entity1 declared they practised sport outside physical education at school (athletic students). Among @entity1 , sport practice mainly concerned activities in clubs or competitions (respectively 66% and 60%, against 35% and 27% among @entity1 ; p<0.001). Twenty-eight percents of @entity1 and 19% of @entity1 declared they had consumed @entity835 (at least occasionnally, during or outside sport). Among athletic students, such potential consumption concerned 28.6% of @entity1 and 19.6% of @entity1 (p<0.001). Moreover, 1.2% of athletic students (n=7) declared they had already consumed @entity835 during the practice sport with clubs or competitions. Among @entity1 , this potential consumption increased with age, was lower among non-athletic students and the most athletic students, but was highest among those practising an individual "X-treme" sport (50% in this group versus 26% among @entity2587 practising collective or non- "X-treme" sport; p<0.001). Potential @entity835 consumption was also highest among @entity2587 who declared they practiced sport for seeking emotions, who did not practise sport for health benefits but who considered that sport could involve taking risks. CONCLUSION: It seems more important to consider how sport is practised rather than its intensity when assessing the association between sport and @entity835 consumption. Indeed, sport appears to be more favourable for @entity835 consumption when associated with ideas of emotion and risk and when practised outside of an organisation.

title: [Sport practice and XXXX consumption in a representative sample of French high school adolescents].

entities_list: @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

answer: @entity835 :: (MESH:D002189,Disease) :: ['cannabis']


abstract: PURPOSE: A phase III trial was performed between October 1981 and June 1984 to compare the efficacy of single-agent @entity900 and single-agent @entity3003 in previously untreated @entity1 with International Federation of Gynecology and Obstetrics stage III or IV @entity43 following surgery. This report describes the survival rates of @entity1 in this study after a minimum follow-up duration of 8 years. @entity1 AND METHODS: Sixty-four @entity1 were randomized to receive @entity900 and 67 @entity1 to receive @entity3003 . @entity900 was administered every 4 weeks for a total of 10 courses, courses 1 to 5 at a dosage of 100 mg/m2 and courses 6 to 10 at 30 mg/m2. @entity3003 was administered at a dosage of 400 mg/m2 every 4 weeks for 10 courses. @entity1 who had clinical or radiologic evidence of response after five courses of chemotherapy underwent second-look surgery. The study was designed to allow crossover between the two arms. Thirteen @entity1 were excluded from response analyses because they were incorrectly randomized. @entity1 were crossed over to the other arm of the study because of @entity74 ( @entity74 ), nonresponse, or @entity137 . RESULTS: The overall response rate for @entity1 randomized to the @entity900 arm was 53.8% (28 of 52; 95% confidence interval [CI], 39% to 68%) and for those randomized to the @entity3003 arm, 38.4% (20 of 52; 95% CI, 25% to 53%). There were 16 (30.8%) and 14 (26.9%) complete remissions (CRs) in the @entity900 and @entity3003 arms, respectively. None of these differences were statistically significant. The median duration of response for the @entity900 and @entity3003 arms was 21 months and 17 months, and the 5-year relapse-free survival rates were 22% and 25%, respectively. The median survival durations for the @entity900 and @entity3003 arms were 19.5 and 13 months, and the 5-year survival rates were 15% (95% CI, 8% to 26%) and 19% (95% CI, 11% to 30%), respectively. None of these differences was statistically significant. The median follow-up duration of @entity1 is 9 years. Crossover due to @entity137 was more frequent in the @entity900 than the @entity3003 arm, occurring in 50% and 3.3% of @entity1 , respectively. CONCLUSION: The mature data from this study of @entity1 with advanced @entity43 show that @entity900 and @entity3003 have similar long-term survival results.

title: Long-term follow-up of the first randomized study of @entity900 versus @entity3003 for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'carcinoma of the ovary']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['Carboplatin', 'carboplatin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['PD', 'progressive disease']

answer: @entity43 :: (MESH:D010051,Disease) :: ['advanced epithelial ovarian cancer']


abstract: The @entity1457 response is a conserved response to cell injury. We sought to determine if @entity63 alone versus events at reperfusion stimulated expression of the major @entity1457 protein (hsp-72) in a clinically relevant model of global @entity741 in @entity1707 . @entity1707 were placed on nonpulsatile cardiopulmonary bypass. Serial transmural cardiac biopsies were taken at baseline following 20 min of normothermic global @entity63 (induced by crossclamping the aorta) and at 20, 40, and 60 min of reperfusion. Test animals received a bolus and subsequent aortic root infusion of @entity224 dismutase (total 7,500 U/kg) beginning just prior to reperfusion. Hsp-72 mRNA abundance was estimated from Northern blots. We found that hsp-72 mRNA was not induced following 20 min of @entity63 but accumulated to high levels within 20 min of reperfusion. Intravascular administration of @entity224 dismutase at reperfusion eliminated hsp-72 mRNA induction. We conclude that in the postischemic myocardium, hsp-72 gene expression is dependent on @entity224 anion generation at reperfusion. In this setting, hsp-72 gene expression may reflect a specific response to oxidative injury rather than a more general response to metabolic stress associated with @entity63 .

title: Myocardial @entity1457 gene expression in XXXX is dependent on @entity224 anion generated at reperfusion.

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

answer: @entity1707 :: (9823,Species) :: ['pigs']


abstract: @entity6962 is a rare gynaecological @entity5 , which is also known as @entity3905 . Traditionally this @entity5 has been regarded as a subtype of uterine @entity242 , and its origin remains controversial. The exact nature and prognosis was not clear in the past. It is believed that uterine @entity6962 have a Mullerian duct origin and have a capacity to differentiate into various mesenchymal and epithelial components. Regarding the histogensis, various theories have been given; of which 'conversion theory' was broadly accepted. @entity6962 are mostly of monoclonal origin with the @entity3909 component being the driving force. This type of @entity5 is broadly divided into two groups, homologous and heterologous, depending on the characteristics of the stroma or mesenchymal components of endometrial tissue. It is more frequent in black @entity1 and postmenopausal @entity1 . Radiation is a possible etiological factor but the exact etiology is not known yet. However, @entity440 may induce @entity105 in some @entity1 . Its clinical feature is very similar to @entity1204 i.e. postmenopausal vaginal @entity548 , have a @entity146 and a poor prognosis. This @entity5 is treated by multimodality therapy including surgery, chemotherapy and radiotherapy. Here we are reviewing old concepts about the disease and modern understandings of the origin, classification, pathogenesis and recent advances in the treatment of the uterine @entity6962 .

title: Review literature on uterine XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'pelvic malignancy', 'neoplasm', 'tumour']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['very aggressive behavior']

entities_list: @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous']

entities_list: @entity3905 :: ('MESH:D018198', 'Disease') :: ['malignant mixed mesodermal tumor']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity6962 :: ('MESH:D002296', 'Disease') :: ['Carcinosarcoma of the uterus', 'carcinosarcoma', 'Carcinosarcoma']

answer: @entity6962 :: (MESH:D002296,Disease) :: ['carcinosarcoma']


abstract: This manuscript reports the results of the first cooperative study on @entity149 ( @entity149 ) in Japan. Of 196 @entity1 registered, 170 were judged as having @entity149 . No @entity1 were immunocompromised. Of the 170 @entity1 with @entity149 , 93 were males and 77 were females. The mean was 56.7 years. One @entity5 were confirmed histopathologically, and 51 were diagnosed by neuroimaging alone. All the @entity5 were @entity1893 . According to the Working Formulation for Clinical Usage (WF), 96 out of 119 @entity5 were classifiable: 53 were diffuse large cell type (55.2%), 17 immunoblastic type (17.7%), 9 diffuse small cleaved type (9.4%), 6 diffuse mixed type (6.3%), 5 polymorphous type (5.2%), 5 small lymphocytic type (5.2%) and 1 small non-cleaved type (1.0%). Of 21 @entity5 studied immunohistochemically, 18 were B-cell type and 3 were T-cell type. Irradiated @entity1 (144) survived significantly longer than non-irradiated @entity1 , (median survival time, @entity1685 : 19.2 and 2.7 months, respectively; p < 0.001). There was a remarkable difference in survival among @entity1 of the intermediate @entity706 ; @entity1685 (18 months) of @entity1 with @entity706 was significantly shorter than @entity1685 (over 96 months) of @entity1 with other intermediate @entity706 (small cleaved and mixed) (p < 0.001) and had no significant difference from @entity1685 (9 months) of @entity1 with high @entity706 . If @entity1 were irradiated with more than 40 Gy, higher doses and different modes of irradiation brought no further survival advantage. Chemotherapy was performed in 87 of 144 irradiated @entity1 (60.4%). No regimens were effective in prolonging survival. Of 144 irradiated @entity1 , a complete or partial response to initial treatment was demonstrated in 91 (63.2%) and 43 @entity1 (29.9%), respectively. Improvement in performance status was confirmed in 82 @entity1 (57.0%). Despite a good response to initial treatments, 88 out of 144 evaluatble @entity1 have died of @entity149 ( @entity1685 : 19 months). Multivariate analysis based on the Cox hazard model revealed that histology of @entity5 , age at onset, performance status, and radiotherapy were prognostic factors. Neither chemotherapy nor mode of surgery was a beneficial factor.

title: XXXX in Japan--a retrospective, co-operative study by @entity706 Study Group in Japan.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas', 'grade lymphomas', 'large cell lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hundred and nineteen tumors', 'tumors']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['PCNSL', 'primary central nervous system lymphoma']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

answer: @entity149 :: (MESH:D002493,Disease) :: ['Primary central nervous system lymphoma']


abstract: PURPOSE: To analyze the correlation of clinical symptom and endoscopic-pathological characteristics of @entity1127 . METHODS: A retrospective study was performed on 1,234 continuous @entity1127 @entity1 . Their clinical, colonoscopic and pathological data were collected and analyzed. RESULTS: In 1,234 @entity1 , 46.0% cases were asymptomatic, and 54.0% cases were symptomatic, and the female to male ratio was 2.23:1 and 1.74:1, respectively (P = 0.048). The mean polyp size in symptomatic group was significantly larger than asymptomatic group [7.6  5.1 mm (95% CI: 7.2, 8.0) vs. 6.3  3.7 mm (95% CI: 6.0, 6.6), P < 0.001]. @entity1127 occurred more frequently in symptomatic group, compared with asymptomatic group (P = 0.002). In symptomatic group, 37.4% cases complained of @entity490 and 62.6% cases complained of bowel habit alteration. The polyp number in @entity490 group was larger than bowel habit alteration group (P = 0.036). Three major symptoms of bowel habit alteration were @entity294 , @entity1142 and @entity360 , with proportion of 54.2% (278/513), 27.7% (142/513) and 18.1% (93/513), respectively. The @entity360 group had larger polyp size than @entity294 group (P = 0.001) and consisted of more villous component than the @entity1142 @entity1 (P = 0.005). CONCLUSION: Almost half of @entity1127 @entity1 do not complain of bowel symptoms, especially the male. @entity1127 @entity1 have bowel habit alteration more commonly than @entity490 . Half of @entity1 with bowel habit alteration demonstrate @entity294 . The @entity360 @entity1 are more susceptible to advanced @entity652 than the @entity294 and @entity1142 ones.

title: Clinical and endoscopic-pathological characteristics of XXXX : an analysis of 1,234 cases.

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['colorectal polyps', 'Tubu-villous polyp and villous polyp', 'Colorectal polyp', 'colorectal polyp']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['hematochezia']

answer: @entity1127 :: (MESH:D011127,Disease) :: ['colorectal polyps']


abstract: BACKGROUND: Clinical efficacy of @entity6542 ( @entity6542 ) with depigmented, polymerized allergen extracts is well documented in placebo-controlled trials, and safety data are encouraging although further data are required. METHODS: We enrolled 768 @entity1 (51% @entity1 ; mean age, 31 years) in this prospective multicenter study on safety and clinical effects of Depigoid (Laboratorios LETI, S.L., Madrid, Spain). Immunotherapy consisted of four injections of increasing doses of Depigoid at weekly intervals followed by monthly maintenance injections. All adverse events were documented. Moreover, nose, eye, and lung symptoms were assessed at baseline after 3 and 6 months. Results were compared with the scores of the preceding season. RESULTS: Rates for local and systemic reactions that might possibly be related to the study medication were 2.36 and 4.56/1000 injections, respectively. With 5923 injections given, 14 local reactions were reported (5 @entity1 ), and 27 systemic reactions were reported, including 20 of grade 1 (6 @entity1 ) and 7 of grade 2 (4 @entity1 ). The best safety profile was seen for @entity1 vaccinated against house-dust mites. Reductions in nose, eye, and lung symptoms as well as in concomitant medication compared with either the preceding season (pollen-sensitized @entity1 ) or the baseline (house-dust mite-sensitized @entity1 ) were observed at the end of study. CONCLUSION: In this large multicenter study on 768 @entity1 with @entity56 and @entity56 under daily practice conditions @entity6542 with Depigoid was well tolerated with low rates of local and systemic reactions. Furthermore, @entity6542 resulted in considerable reductions in symptoms and concomitant medication.

title: Safety of a depigmented, polymerized vaccine for the treatment of @entity56 and XXXX .

entities_list: @entity6542 :: ('MESH:C562465', 'Disease') :: ['specific immunotherapy', 'SIT']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic rhinoconjunctivitis', 'allergic asthma']

answer: @entity56 :: (MESH:D004342,Disease) :: ['allergic asthma']


abstract: OBJECTIVES: We hypothesized that administration of bevacizumab, a monoclonal antibody that neutralizes @entity7 , in combination with high-dose @entity4020 ( @entity4020 ), an inhibitor of basic fibroblast growth factor, would have clinical activity in @entity1 with metastatic @entity320 . METHODS: @entity1 with metastatic @entity320 received bevacizumab (15 mg/kg intravenously every 2 weeks) plus @entity4020 (5 MU/m subcutaneously 3 times weekly for 2 weeks followed by a dose of 10 MU/m subcutaneously thereafter). @entity1 exhibiting a clinical response or stabilization of disease were treated until disease progression. RESULTS: In this pilot study, 5 @entity1 were treated (3 @entity1 , 2 @entity1 ) with a mean age of 63.8 years (range, 53-71 years). Overall, the regimen was well-tolerated. The following adverse events were noted: grade 3 @entity1353 (2 @entity1 ), grade 3 and 4 fatigue (2), grade 3 @entity425 (1), grade 3 @entity448 (1), grade 1 and 2 @entity644 (2), and grade 3 @entity294 (1). All adverse events resolved with a treatment holiday or dose reduction. One @entity1 had reduction in @entity5 burden of 23% by Response Evaluation Criteria in Solid Tumors criteria and 2 @entity1 had stabilization of disease lasting 28 and 36 weeks, respectively. Two @entity1 failed to respond and progressed after 6 and 7 weeks of therapy. CONCLUSION: Bevacizumab and @entity4020 were well tolerated in this @entity1 population, and clinical activity was observed. Further study of high-dose @entity4020 in combination with bevacizumab in this setting is warranted.

title: A pilot study of bevacizumab and interferon-a2b in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['muscle weakness']

entities_list: @entity4020 :: ('3440', 'Gene') :: ['IFN-a2b', 'interferon-alpha2b']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['ocular melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['ocular melanoma']


abstract: AIMS: @entity1 with recent onset @entity296 have a variable clinical course with respect to recovery of @entity1002 ( @entity1002 ). The aim of this study was to understand whether temporal changes in @entity5488 ( @entity5488 ) are associated with clinical outcomes independent of @entity1002 recovery. METHODS AND RESULTS: The Intervention in @entity2401 and Acute @entity296 (IMAC)-2 study was a prospective, multicentre trial investigating myocardial recovery in subjects with symptoms onset of <6 months and @entity1002  <=40% of @entity384 related to idiopathic @entity296 or @entity2401 . @entity1002 and @entity5488 were measured at presentation and at 6-month follow-up. Of 147 @entity1 (mean age 46    14 years, 40% female), baseline @entity1002 was 23    8%. At 6 months, @entity1002 improved to 41    12%, with 71% increasing by at least 10% ejection fraction units. @entity5488 improved in 58%, was unchanged in 28%, and worsened in 14%. Over a mean follow-up of 1.8    1.2 years, there were 18 events: 11 @entity712 ( @entity712 ) hospitalizations, 3 deaths, and 4 heart transplants. @entity1002 (HR = 0.94, 95% CI 0.91-0.98, P = 0.002) and @entity5488 improvements at 6 months (HR = 0.32, 95% CI 0.11-0.92, P = 0.03) were independently associated with lower likelihood for the combined end point of @entity204 , transplantation, and @entity712 hospitalization. Diastolic functional improvement at 6-month follow-up was as prognostically important as @entity1002 recovery for these @entity1 , and provided incremental prognostic value to the risk stratification (X(2) increased from 12.6 to 18, P = 0.02). CONCLUSION: In @entity1 with recent onset @entity296 , @entity5488 recovery was associated with favourable outcomes independent of @entity1002 improvement, adding incremental prognostic value to these @entity1 .

title: Diastolic function improvement is associated with favourable outcomes in XXXX with acute @entity296 : insights from the multicentre IMAC-2 trial   .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'non-ischaemic cardiomyopathy', 'Cardiomyopathy']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['non-ischaemic dilated cardiomyopathy']

entities_list: @entity5488 :: ('MESH:D054144', 'Disease') :: ['DF', 'diastolic function']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['Myocarditis', 'myocarditis']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVEF', 'left ventricular ejection fraction']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity4154 ( @entity4154 ) is a major cause of morbidity and mortality after lung transplantation (LTx). We sought to better understand the relationship between alloimmune responses and @entity792 and, subsequently, how @entity792 leads to chronic rejection. METHODS: We analyzed the development of donor-specific antibodies (Abs) in LTx by flow PRA and the development of Abs to K-a1 tubulin (K-a1T) and collagen V (ColV) by ELISA. The frequency of K-a1T- and ColV-specific T cells that secrete @entity379 , @entity4155 and @entity688 in LTx recipients was measured by ELISPOT. RESULTS: In a retrospective analysis of 42 LTx recipients, we demonstrated a strong correlation between development of donor-specific anti-HLA Abs, Abs to self-antigens and @entity4154 (p < 0.05). To test the hypothesis that alloimmunity is related to an immune response to self-antigens, we analyzed 103 LTx @entity1 prospectively for the development of donor-specific Abs (DSA) and Abs to self-antigens. A total of 42.7% of recipients developed DSA and 30.1% developed Abs to K-a1T and ColV. Development of DSA preceded development of Abs to self-antigens. @entity4154 (+) @entity1 had higher frequency of T cells secreting @entity4155 (p < 0.01) and @entity379 (p < 0.05) with decreased @entity688 (p < 0.05) when compared with @entity4154 (-) @entity1 . CONCLUSIONS: Based on these results we propose that alloimmune responses to donor HLA can induce autoimmune responses to airway epithelial self-antigens, characterized by activation of the @entity4155 pathway. These immune responses to self-antigens along with alloimmunity contribute to the pathogenesis of @entity4154 . Strategies to prevent development of @entity792 may be play a key role in preventing the development of chronic rejection.

title: Alloimmunity-induced @entity792 as a potential mechanism in the pathogenesis of chronic rejection of XXXX lung allografts.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4154 :: ('MESH:D001989', 'Disease') :: ['Bronchiolitis obliterans syndrome', 'BOS']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: @entity2742 in pregnancy is a threat to the health of both mother and fetus. The mothers suffer commonly from @entity1790 , @entity7494 , or even hypercalcemic crisis. @entity66 will commonly complicate fetal development and @entity5617 is a significant risk. Treatment options, including medical and surgical therapy, are debated in the literature. METHODS: This is a case series comprising seven @entity1 with @entity459 in pregnancy. Data collected included symptoms at diagnosis, biochemical abnormalities, pathologic findings, treatment regimes, and subsequent maternal and fetal outcomes. RESULTS: Seven @entity1 , aged 20 to 39 years, presented with @entity2742 during pregnancy. The earliest presented at 8 weeks and the latest at 38 weeks. Four of seven @entity1 experienced @entity1290 . @entity460 levels were 2.7-3.5 mmol/l. All were found to have solitary @entity3243 , of which two were in ectopic locations. Fetal complications included three preterm deliveries and one @entity5617 with no cases of neonatal @entity116 . @entity2241 could not be predicted based on duration or severity of @entity2741 . Three @entity1 were treated during pregnancy with surgery, and two of these had ectopic glands that required reoperations with a novel approach using Tc-99m sestamibi scanning during pregnancy to assist in localizing the abnormal gland. Four cases were treated postpartum with a combination of open and minimally invasive approaches after localization. No operative complications or fetal loss related to surgery were observed in this cohort. CONCLUSIONS: @entity459 in pregnancy represents a significant risk for @entity2241 that cannot be predicted by duration of symptoms or serum @entity460 levels. Surgical treatment should be considered early, and a minimally invasive approach with ultrasound is best suited to mitigating risk to mother and fetus. Equally important, Tc-99m sestamibi imaging may be used safely for localization of the parathyroids after negative cervical explorations.

title: XXXX in pregnancy: options for localization and surgical therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity459 :: ('MESH:D049950', 'Disease') :: ['Primary hyperparathyroidism', 'primary hyperparathyroidism']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Untreated disease']

entities_list: @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia']

entities_list: @entity7494 :: ('MESH:D006939', 'Disease') :: ['hyperemesis']

entities_list: @entity5617 :: ('MESH:D005313', 'Disease') :: ['fetal death']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['renal calculi']

entities_list: @entity1790 :: ('MESH:D053040', 'Disease') :: ['nephrolithiasis']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium']

entities_list: @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid adenomas']

entities_list: @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism', 'Hyperparathyroidism']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['Maternal and fetal complications', 'maternal and fetal complications']

answer: @entity2742 :: (MESH:D006961,Disease) :: ['Hyperparathyroidism']


abstract: We performed a quantitative review of associations between the higher order personality traits in the Big Three and Big Five models (i.e., @entity663 , extraversion, @entity4943 , conscientiousness, agreeableness, and @entity1538 ) and specific @entity308 , @entity148 , and @entity734 ( @entity734 ) in adults. This approach resulted in 66 meta-analyses. The review included 175 studies published from 1980 to 2007, which yielded 851 effect sizes. For a given analysis, the number of studies ranged from three to 63 (total sample size ranged from 1,076 to 75,229). All diagnostic groups were high on @entity663 (mean Cohen's d = 1.65) and low on conscientiousness (mean d = -1.01). @entity74 also showed low extraversion, with the largest effect sizes for @entity14256 (d = -1.47) and @entity913 (d = -1.31). Disinhibition was linked to only a few conditions, including @entity734 (d = 0.72). Finally, agreeableness and @entity1538 were largely unrelated to the analyzed diagnoses. Two conditions showed particularly distinct profiles: @entity734 , which was less related to @entity663 but more @entity428 , and @entity6542 , which displayed @entity1112 . Moderator analyses indicated that epidemiologic samples produced smaller effects than @entity1 samples and that Eysenck's inventories showed weaker associations than NEO scales. In sum, we found that common @entity146 are strongly linked to personality and have similar trait profiles. @entity663 was the strongest correlate across the board, but several other traits showed substantial effects independent of @entity663 . Greater attention to these constructs can significantly benefit psychopathology research and clinical practice.

title: Linking "big" personality traits to @entity148 , @entity308 , and XXXX : a meta-analysis.

entities_list: @entity6542 :: ('MESH:C562465', 'Disease') :: ['specific phobia']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

entities_list: @entity14256 :: ('MESH:D019263', 'Disease') :: ['dysthymic disorder']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['elevated on disinhibition and disagreeableness']

entities_list: @entity913 :: ('MESH:D010698', 'Disease') :: ['social phobia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders']

entities_list: @entity1112 :: ('MESH:D040181', 'Disease') :: ['weaker links to all traits']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Many disorders']

entities_list: @entity663 :: ('MESH:C564323', 'Disease') :: ['neuroticism', 'Neuroticism']

entities_list: @entity4943 :: ('MESH:D057180', 'Disease') :: ['disinhibition']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['substance use disorders', 'SUD']

answer: @entity734 :: (MESH:D019966,Disease) :: ['substance use disorders']


abstract: BACKGROUND: @entity652 of the ampulla of Vater and the duodenum are rare @entity5 . The leading symptoms are unspecific; sometimes they are due to the disturbances of the passage or erosion of the @entity5 . Early and correct diagnosis and the appropriate therapy are of decisive importance because these @entity5 are precancerous. @entity1 AND METHODS: We report the cases of seven @entity1 with periampullary @entity652 of the duodenum, in one case with incorporation of the the distal bile duct. The diagnostic steps and the surgical treatment are reported and discussed. In achieving a definitive diagnosis, endoscopic retrograde cholangiopancreatography is of paramount importance. Three @entity1 subsequently underwent partial pancreatoduodenectomy (Whipple's procedure); in three @entity1 transduodenal local @entity5 excision was performed. Postoperative course was without complications in each case and no operative mortality occurred. One @entity1 was treated by @entity3503 -coagulation. RESULTS: The histopathological examination showed a tubular @entity5493 in six cases and in one case a @entity5493 (ranging from low to high grade @entity1141 ). Because there is evidence of an @entity2513 -sequence, radical surgical treatment is recommended, even in @entity652 with @entity258 , in spite of the absence of @entity5 .

title: [ XXXX of Vater's ampulla and of the duodenum. Presentation of diagnosis and therapy by endoscopic interventional and surgical methods].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity5493 :: ('MESH:D018253', 'Disease') :: ['villous adenoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy', 'tumors']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['Adenoma', 'adenoma']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low grade dysplasia']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma-carcinoma']

answer: @entity652 :: (MESH:D000236,Disease) :: ['Adenomas']


abstract: UNASSIGNED: If over-suppression of bone turnover explained the association between @entity5520 use and @entity173 ( @entity173 ), this could be reversed with anabolic treatment such as @entity15896 . We conducted a prospective, open label study in @entity1 previously treated with @entity171 who sustained @entity173 , examining the response to 24 months treatment with @entity15896 on @entity79 ( @entity79 ), @entity79 ( @entity79 ), bone turnover markers (BTM) and @entity174 healing as well as quantitative histomorphometry. We studied 14 @entity1 . Baseline @entity79 , BTM and @entity79 varied widely. On initial bone biopsies, 12 of 14 @entity1 showed @entity803 labels, but mineralizing surface/bone surface was below published normal values in all but 2. Lumbar spine @entity79 increased significantly at Month 24 (6.1%        4.3%, p   <   0.05 vs Baseline) while total hip @entity79 and @entity79 did not change significantly. Changes in BTM occurred as reported previously for @entity1 without @entity173 treated with @entity15896 after prior @entity5520 treatment. At Month 24, factures were healed 6 @entity1 , showed partial healing in 3, unchanged in 2 and nonunion in 1. In a @entity1 with two @entity174 , the @entity174 that occurred prior to @entity15896 treatment was reported as healed but the @entity174 that occurred while on treatment showed only partial healing. @entity5520 -treated @entity1 who sustain @entity173 show heterogeneity of bone turnover. Treatment with @entity15896 resulted in increases in BTM and lumbar spine @entity79 , as has been reported for @entity1 without @entity173 . There was no significant effect of @entity15896 on hip @entity79 , @entity15 /BS or @entity79 and no consistent effect on @entity174 healing. In the context of a @entity1 who has experienced an @entity173 after receiving @entity5520 treatment, therapy with @entity15896 for 24 months would be expected to increase @entity79 and BTM (and probably reduce the risk of @entity174 due to @entity170 ) but should not be relied on to aid in healing of the @entity173 . This article is protected by copyright. All rights reserved.

title: Responses to Treatment with @entity15896 in @entity1 with Atypical @entity174 Previously Treated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity15896 :: ('MESH:D019379', 'Chemical') :: ['teriparatide']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity5520 :: ('D004164', 'Chemical') :: ['Bisphosphonate', 'bisphosphonate']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['AFF', 'atypical subtrochanteric femur fractures']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD', 'trabecular bone score', 'TBS']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

answer: @entity171 :: (MESH:D004164,Chemical) :: ['Bisphosphonates']