abstract: @entity409 is a prominent feature of @entity3119 ( @entity3119 ). In the present study we assessed orbitofrontal functioning in @entity1277 ( @entity1277 ) which share many features with @entity3119 . For this purpose we studied female adolescent inpatients with @entity448 nervosa restricting type (n=40), @entity1278 /purge type (n=23), a normal weight group including @entity1 with either @entity1279 or eating disorder not otherwise specified-purging type (n=33), and 20 non- @entity2613 control females. @entity1 were assessed at admission, and when achieving weight restoration and symptom stabilization at discharge, for @entity308 , non- @entity2613 , and @entity2613 -related OC symptoms. Orbitofrontal functioning was assessed with an alternation learning task, and with a battery assessing olfactory threshold and discrimination. Control females were assessed once. @entity2613 @entity1 of all subtypes performed better on olfactory threshold and discrimination, but not on alternation learning, in comparison to healthy controls. More favorable orbitofrontal functioning was associated with greater @entity2613 -related obsessionality. No changes were found in olfactory threshold and discrimination between acutely-ill and symptomatically-stabilized @entity1 . The improvement shown in alternation learning from admission to discharge was suggested to reflect a learning effect rather than being an actual change. Our findings suggest that the better orbitofrontal functioning of @entity2613 @entity1 in comparison to healthy controls may represent a core feature of the @entity2613 that is independent of @entity3147 and deranged @entity146 , but is associated with @entity2613 -related obsessionality.

title: Olfactory function and alternation learning in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['eating behaviors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Orbitofrontal dysfunction']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa binge']

entities_list: @entity1277 :: ('MESH:D001068', 'Disease') :: ['EDs', 'eating disorders']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity1279 :: ('MESH:D052018', 'Disease') :: ['bulimia nervosa']

entities_list: @entity3119 :: ('MESH:D009771', 'Disease') :: ['OCD', 'obsessive compulsive disorder']

answer: @entity1277 :: (MESH:D001068,Disease) :: ['eating disorders']


abstract: BACKGROUND: Treatment option for @entity0 ( @entity0 ) @entity1 pre-treated with chemotherapy is limited. Oral @entity2879 has shown some promises in these @entity1 . However, @entity1 who received heavy prior chemotherapy may have poor tolerance to prolonged oral @entity2879 exposure. This study is a single-arm clinical trial that evaluates the efficacy and safety of short-term oral @entity2879 in Chinese @entity1 with @entity0 who had received heavy prior therapy. METHODS: @entity0 @entity1 receiving at least two chemotherapy regimens prior to the enrollment were treated with repeated cycles of oral @entity2879 (60 mg m(-2) d(-1) on days 1-10, followed by 11 days of rest). The primary end point was the progression free survival (PFS). The secondary end points were objective response rate (ORR), clinical benefit rate (CBR), @entity1349 ( @entity1349 ), and @entity137 profiles. RESULTS: Thirty-two @entity1 received 230 cycles of oral @entity2879 with a median of 6 cycles (range, 2-20 cycles) per @entity1 . Eight @entity1 (25%) had partial response (PR) and 14 @entity1 achieved @entity66 ( @entity66 ). The ORR was 25%. Nine @entity1 achieved @entity66 for more than 24 weeks and CBR was 53%. The median PFS and @entity1349 were 5 (range, 1.5-17.0 months) and 16 months (range, 3.0-51.0 months), respectively. The @entity1 who achieved clinical benefit had longer survival time than those who did not (25.0 versus 11.0 months, P<0.01). Among the 16 @entity1 who received more than four regimens prior to this study, four @entity1 achieved PR and four achieved @entity66 for more than 24 weeks, with a CBR of 50%. The most common hematologic adverse events were @entity417 (43.8%) and @entity1398 (38.5%). @entity1209 (75.0%) and @entity1665 (62.5%) were the most frequent @entity1503 . CONCLUSION: Oral @entity2879 is effective and well tolerated in Chinese @entity1 with heavily pretreated @entity0 .

title: Oral XXXX monotherapy is effective for @entity0 with heavy prior therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['metastatic breast cancer', 'MBC']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['stable disease', 'SD']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['non-hematologic toxicities']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['Nausea/vomiting']

answer: @entity2879 :: (MESH:D005047,Chemical) :: ['etoposide']


abstract: VerifyNow (VN) @entity3075 is a point-of-care assay used to assess response to @entity3075 inhibitors. @entity4958 ( @entity1792 ) is the standard anticoagulant used for this assay but requires a pre-incubation period. Hirudin is an alternative anticoagulant for platelet function studies that maintains physiological divalent cation levels. We investigated whether hirudin anticoagulation might allow more rapid testing of P2Y       inhibition at the time of percutaneous coronary intervention (PCI). Blood was collected from the arterial sheath of @entity117 -treated @entity1 undergoing elective, urgent or emergency coronary angiography  PCI and aliquots were anticoagulated with either @entity1792 or hirudin. For each anticoagulant, VN @entity3075 was performed both immediately and after 20 minutes. A total of 98 @entity1 were included in this study following pre-treatment with @entity1397 (n=88), @entity3076 (n=6) or no P2Y       inhibitor (n=4). PRU with hirudin immediately (PRU_H_Imm) and PRU with @entity1792 20 minutes post sampling (PRU_C_20) were very strongly correlated (R=0.95) though PRU_H_Imm tended to be lower than PRU_C_20 so that optimal correlation was estimated by the equation PRU_H_Imm=0.95xPRU_C_20 (p<0.001). Bland-Altman plots showed good agreement between PRU_H_Imm and (0.95xPRU_C_20). Platelet reactivity was more stable over the studied time course with hirudin as compared to @entity1792 . We therefore conclude that VN @entity3075 with hirudin anticoagulation can be performed more rapidly and results are strongly correlated with delayed @entity1792 measurements. Further studies are warranted to assess the utility of this method for improving clinical outcomes in @entity1 undergoing PCI.

title: Hirudin anticoagulation allows more rapid determination of P2Y       inhibition by the VerifyNow XXXX assay.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4958 :: ('MESH:C102006', 'Chemical') :: ['Sodium citrate']

entities_list: @entity3076 :: ('MESH:C408153', 'Chemical') :: ['prasugrel']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

answer: @entity3075 :: (64805,Gene) :: ['P2Y12']


abstract: BACKGROUND: @entity2690 resistance (IR), constitutes an important @entity65 factor and can cause @entity741 . It can lead to left @entity67 with a mechanism independent of @entity741 and it is closely associated with @entity73 . The aim of our study was to explore the impact of IR on @entity299 , in @entity1 with @entity65 factors but angiographically undamaged coronary arteries. METHODS: We studied 32 @entity1 (62.06  11.19years) with @entity65 factors. All @entity1 underwent coronary angiography, echocardiography, Doppler ultrasound of carotid arteries and laboratory tests. Exclusion criteria were @entity453 detected by coronary angiography, @entity6 , @entity1011 above 1.5mg/dl, @entity955 or malignant @entity943 , @entity4346 , @entity340 , ejection fraction below 50%. The presence of @entity2690 resistance was assessed using the Homeostasis Model Assessment of @entity2690 Resistance (HOMA-IR). Each @entity1 underwent a complete echocardiographic examination including @entity6475 assessment and carotid artery ultrasound scan including measurement of arterial stiffness. RESULTS: The @entity1 were divided into two groups based on the median value of HOMA-IR, the first group for values <4.14 and, the second, for values >= 4.14. Ejection fraction and diastolic function did not significantly differ between the two groups, whether in @entity1 with higher levels of HOMA-IR (>= 4.14) we observed a @entity6475 ( @entity6475 ) that was significantly reduced (-16.50  1.37% vs. -20.73  1.84%, p=0.0015) @entity455 , measured in the carotid arteries as pulse wave velocity ( @entity122 ) (9.70  1.75m/s vs. 7.40  1.89m/s, p=0.00148) that was increased. At multivariate analysis HOMA-IR was an independent predictor of @entity296 ( @entity6475 : coefficient 0.1156, p<0.0001). CONCLUSION: @entity2690 resistance is associated with subclinical @entity296 in @entity1 without significant @entity453 , measured as a @entity6475 , and increased arterial stiffness. Our results underscore the importance of studying the interaction between ventricular function and vessels, in the perspective of more effective preventive and therapeutic interventions.

title: Impact of @entity2690 resistance on XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular heart disease']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular stiffness']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial and vascular alterations', 'myocardial dysfunction']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired vascular function']

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['Global Longitudinal Strain', 'reduction of Global Longitudinal Strain', 'GLS']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['left-ventricular hypertrophy']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac and vascular function']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular risk']

answer: @entity299 :: (MESH:D006331,Disease) :: ['cardiac and vascular function']


abstract: PURPOSE: Engaging parents in interventions can be difficult because of various barriers. An engaging @entity1 's program that runs parallel to a parent program may facilitate parent participation. In this study, we assessed parents' perception of the @entity1 's component of Parents and Tots Together (PTT), a family-based @entity28 prevention program. METHODS: Fifteen of the 16 ethnically diverse parents who participated in an uncontrolled trial of PTT completed a survey assessing their satisfaction with the PTT @entity1 's component. More detailed information was obtained from one-on-one qualitative interviews with seven parents. RESULTS: Attendance at program sessions was relatively high; 69% of parents attended six or more of the nine sessions. Survey data revealed that 87% of parents were "very satisfied" with the @entity1 's group. Approximately 73% of parents reported that the program was "very useful" in helping their @entity1 learn the importance of healthy eating and physical activity. In qualitative interviews, many parents identified the @entity1 's program as a motivator for attendance at the program sessions. CONCLUSIONS: The interactive @entity1 's program was well received by parents and may serve as a catalyst for parent participation. Larger, randomized trials are needed to determine the effectiveness of @entity1 's programming for enhancing parent participation.

title: An approach to improve parent participation in a childhood XXXX prevention program.

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'children']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: OBJECTIVE: To determine the relationship between @entity1348 ( @entity1348 ), sex and @entity158 severity. METHODS: Data were collected prospectively from consecutive @entity1 with @entity1348 . @entity1 were divided into four subgroups according to signs and symptoms: @entity158 ; @entity7334 ; @entity74 ; @entity179 . Intergroup sex distribution differences were evaluated, the @entity158 severity between the four subgroups was compared, and the rates of @entity8599 and inco-ordination were measured. A visual analogue scale was used to rate the @entity158 . RESULTS: A total of 255 @entity1 with @entity1348 were included in the study. A significantly higher rate of @entity74 was found in male @entity1 . @entity8599 was found to be significantly more common in females than in males. There was no significant difference in the prevalence of inco-ordination based on sex. The overall @entity158 score was higher in females than in males, but there was no significant difference. The @entity158 score was significantly higher in @entity1 in the @entity179 subgroup, compared with other subgroups. CONCLUSIONS: There was no relationship between @entity1348 and @entity158 and sex. @entity158 scores were significantly higher in the @entity179 subgroup, compared with other subgroups.

title: @entity1348 : a prospective study of 255 consecutive XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative disorders']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['extra-articular disorders']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['myofascial pain', 'Pain', 'pain']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['intra-articular disorders']

entities_list: @entity1348 :: ('MESH:D013706', 'Disease') :: ['TMDS', 'temporomandibular dysfunction syndrome']

entities_list: @entity8599 :: ('MESH:D002012', 'Disease') :: ['bruxism', 'Bruxism']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Episodic memory, as defined by Tulving, can be described in terms of behavioural elements (what, where and when information) but it is also accompanied by an awareness of one's past (chronesthesia) and a subjective conscious experience (autonoetic awareness). Recent experiments have shown that corvids and rodents recall the where, what and when of an event. This capability has been called @entity2414 because it only fulfils the behavioural criteria for episodic memory. We tested seven @entity831 , three @entity17055 and two @entity4839 of various ages by adapting two paradigms, originally developed by Clayton and colleagues to test scrub jays. In Experiment 1, subjects were fed preferred but perishable food (frozen juice) and less preferred but non-perishable food (grape). After the food items were hidden, subjects could choose one of them either after 5 min or 1 h. The frozen juice was still available after 5 min but melted after 1 h and became unobtainable. Apes chose the frozen juice significantly more after 5 min and the grape after 1 h. In Experiment 2, subjects faced two baiting events happening at different times, yet they formed an integrated memory for the location and time of the baiting event for particular food items. We also included a memory task that required no temporal encoding. Our results showed that apes remember in an integrated fashion what, where and when (i.e., how long ago) an event happened; that is, apes distinguished between different events in which the same food items were hidden in different places at different times. The temporal control of their choices was not dependent on the familiarity of the platforms where the food was hidden. @entity831 ' and @entity4839 ' performance in the temporal encoding task was age-dependent, following an inverted U-shaped distribution. The age had no effect on the performance of the subjects in the task that required no temporal encoding.

title: Keeping track of time: evidence for XXXX in great apes.

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['episodic-like memory']

entities_list: @entity831 :: ('9598', 'Species') :: ['chimpanzees', 'Chimpanzees']

answer: @entity2414 :: (MESH:D008569,Disease) :: ['episodic-like memory']


abstract: The @entity15389 ( @entity15390 ) transport system of @entity526 K92 was studied when this bacterium was grown in a chemically defined medium containing @entity15390 as @entity505 source. Kinetic measurements were carried out in vivo at 37 degrees C in 25 mM @entity1391 buffer, pH 7.5. Under these conditions, the uptake rate was linear for at least 15 min and the calculated Km for @entity15390 was 280 microM. The transport system was strongly inhibited by @entity24808 (97%), @entity3983 (84%) and @entity3212 (88%) added at final concentrations of 1 mM (each). Analysis of bacterial @entity15390 phosphotransferase activity revealed in vitro @entity15390 phosphorylation activity only when @entity7954 was present. These results strongly support the notion that @entity15390 uptake depends on a specific phosphotransferase system. Study of specificities showed that @entity3954 and @entity31158 specifically inhibited the transport of @entity15390 in this bacterium. Analysis of expression revealed that the @entity15390 transport system was induced by @entity15390 , @entity4823 , @entity11485 , @entity31158 and @entity3913 but not by @entity3954 or @entity10811 . Moreover, @entity15390 permease was subject to @entity413 repression and @entity268 stimulation. Full induction of the @entity15390 transport system required the simultaneous presence of both @entity268 and @entity15390 .

title: Uptake of XXXX : an essential intermediate in polysialic acid biosynthesis by @entity526 K92.

entities_list: @entity3954 :: ('CHEBI:28009', 'Chemical') :: ['N-acetylglucosamine']

entities_list: @entity7954 :: ('MESH:D010728', 'Chemical') :: ['phosphoenolpyruvate']

entities_list: @entity15389 :: ('MESH:C002022', 'Chemical') :: ['N-acetyl-D-mannosamine']

entities_list: @entity11485 :: ('MESH:D005688', 'Chemical') :: ['galactosamine']

entities_list: @entity4823 :: ('MESH:D005944', 'Chemical') :: ['glucosamine']

entities_list: @entity3212 :: ('MESH:D019297', 'Chemical') :: ['2,4-dinitrophenol']

entities_list: @entity10811 :: ('CHEBI:28800', 'Chemical') :: ['N-acetylgalactosamine']

entities_list: @entity3983 :: ('MESH:D011190', 'Chemical') :: ['potassium cyanide']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity31158 :: ('MESH:C008322', 'Chemical') :: ['mannosamine']

entities_list: @entity24808 :: ('MESH:C009277', 'Chemical') :: ['sodium arsenate']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity15389 :: (MESH:C002022,Chemical) :: ['N-acetyl-D-mannosamine']


abstract: BACKGROUND: Although single bone intramedullary (IM) fixation has been advocated in the treatment of unstable @entity174 , some reports have questioned the ability of single bone fixation to maintain adequate reduction. The purpose of this investigation is to report the radiographic and early clinical results of single bone IM fixation for @entity174 and to identify factors leading to loss of reduction of the radius after ulnar fixation. METHODS: A retrospective analysis of 38 @entity1 who underwent single bone IM fixation of the ulna for both @entity174 was performed. Mean age was 9 years (range: 4-14 y). Preoperative, postoperative, and final follow-up radiographs were examined for radiographic alignment. @entity1 data (including age, @entity174 type, delay to fixation, open vs. percutaneous reduction and fixation, and time to implant removal) was collected to identify predictors for loss of reduction of the radius. Loss of reduction of the radius was defined as 10 degrees or greater change of angulation in either the frontal or lateral plane from initial postoperative radiographs to final follow-up. Multivariate analysis was used to determine associations between @entity1 factors and loss of reduction. RESULTS: All @entity1 went on to bony union with restoration of @entity717 . Twenty-five @entity1 (66%) healed with <10 degrees of angulation of the radius, whereas 11 @entity1 (29%) had between 10 and 20 degrees of angulation at final follow-up. Two @entity1 demonstrated greater than 20 degrees of radial angulation requiring additional surgical care. There was no statistically significant association between any @entity1 factors and loss of radial reduction, though there was a trend for increased radial angulation in @entity1 who had sustained @entity4422 . CONCLUSIONS: Single-bone IM fixation of the ulna is a safe and efficacious option for the treatment of unstable @entity174 in @entity1 . Owing to the increased risk of loss of radial reduction, however, consideration should be made for IM fixation of both bones in older @entity1 and cases of @entity4422 . LEVEL OF EVIDENCE: IV, therapeutic.

title: Single bone intramedullary fixation of the ulna in pediatric both XXXX : analysis of short-term clinical and radiographic results.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'Patient']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['forearm rotation']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['bone forearm fractures', 'fracture', 'diaphyseal forearm fractures']

entities_list: @entity4422 :: ('MESH:D005597', 'Disease') :: ['open fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['bone forearm fractures']


abstract: AIMS: To perform a comprehensive evaluation of @entity299 and the influence of disease/therapy factors in a large @entity1252 ( @entity1252 ) cohort. METHODS AND RESULTS: Three hundred and seventeen consecutive @entity1 of an ongoing electronic database protocol were evaluated by resting electrocardiogram and 142 were randomly selected for 24 h Holter monitoring for @entity943 and conduction disturbances. The mean age was 40.2    12.1 years and disease duration was 11.4    8.1 years. @entity503 (CQ) therapy was identified in 69.7% with a mean use of 8.5    6.7 years. Electrocardiogram abnormalities were detected in 66 @entity1 (20.8%): prolonged QTc/QTd (14.2%); @entity5036 (2.5%); and @entity713 ( @entity713 ) (1.6%). Age was associated with @entity713 (P = 0.029) and prolonged QTc/QTd (P = 0.039) whereas anti-Ro/ @entity6540 and @entity1252 Activity Index (SLEDAI) scores were not (P > 0.05). @entity503 was negatively associated with @entity713 (P = 0.01) as was its longer use (6.1    6.9 vs. 1.0    2.5 years, P = 0.018). Time of CQ use was related with the absence of @entity713 [odds ratio (OR) = 0.103; 95% confidence interval (CI) = 0.011-0.934, P = 0.043] in multiple logistic regression. Holter monitoring revealed abnormalities in 121 @entity1 (85.2%): supraventricular ectopies (63.4%) and @entity591 (18.3%); ventricular ectopies (45.8%). @entity955 ( @entity955 ) were associated with shorter CQ duration (7.05    7.99 vs. 3.63    5.02 years, P = 0.043) with a trend to less CQ use (P = 0.054), and older age (P < 0.001). Predictors of @entity955 in multiple logistic regression were age (OR = 1.115; 95% CI = 1.059-1.174, P < 0.001) and anti-Ro/ @entity6540 (OR = 0.172; 95% CI = 0.047-0.629, P = 0.008). CONCLUSIONS: @entity503 seems to play a protective role in the unexpected high rate of @entity943 and conduction disturbances observed in @entity1252 . Further studies are necessary to determine if this antiarrhythmic effect is due to the disease control or a direct effect of the drug.

title: Evidence for cardiac safety and antiarrhythmic potential of XXXX in @entity1252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block', 'AVB']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'Systemic Lupus Erythematosus Disease']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachyarrhythmia']

entities_list: @entity5036 :: ('OMIM:113900', 'Disease') :: ['bundle-branch block']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['AT/AF', 'Atrial tachycardia/fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart rhythm disorders']

entities_list: @entity503 :: ('MESH:D002738', 'Chemical') :: ['Chloroquine']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia', 'cardiac arrhythmias']

answer: @entity503 :: (MESH:D002738,Chemical) :: ['chloroquine']


abstract: 1. Single and dual intracellular recordings were performed in neocortical slices obtained from tissue samples surgically removed from @entity1 (8 mo to 15 yr) for the treatment of intractable @entity302 . Electrical stimulation and @entity2227 microapplication were used to study local synaptic inputs to pyramidal cells. 2. In recordings with @entity4782 electrodes, activation of presynaptic neocortical neurons with @entity2227 microdrops did not elicit a clear increase in postsynaptic potentials (PSPs) but did suppress current-evoked repetitive spike firing in recorded neurons. @entity1027 (10 microM) blocked this effect, suggesting it was caused by the activation of presynaptic @entity1246 ( @entity1246 ) cells. In recordings with @entity4338 electrodes, @entity2227 microdrops elicited an increase in the frequency and amplitude of depolarizing PSPs. @entity1027 (5-10 microM) blocked the @entity2227 -evoked PSPs, suggesting they were reversed GABAA-receptor-mediated inhibitory postsynaptic potentials (IPSPs). In one cell recorded with a @entity4338 electrode (total n = 8), current-evoked spike trains elicited afterdischarges of reversed IPSPs, thus revealing a recurrent inhibitory circuit. Therefore local inhibitory synaptic circuits were robust and could be observed in tissue from @entity1 as young as 11 mo. 3. In addition to short-latency (10-25 ms), monosynaptic excitatory postsynaptic potentials (EPSPs), electrical stimulation at low intensities sometimes elicited delayed EPSPs (20-60 ms). When GABAA-receptor-mediated synaptic inhibition was partially reduced in @entity1027 (5-10 microM), electrical stimulation evoked large EPSPs at long and variable latencies (100-300 ms). @entity2227 microapplication caused an increase in the frequency and amplitude of EPSPs; preliminary results suggest that @entity2227 microdrops were less likely to evoke EPSPs in tissue from younger @entity1 (8-12 mo) than in slices from @entity1 greater than 4 yr. Evidence for local excitatory synaptic circuits was thus found when synaptic inhibition was partially reduced. 4. After further reduction of inhibition in @entity1027 (5-50 microM), electrical stimulation elicited @entity302 . In pairs of simultaneously recorded neurons, bursts were generated synchronously from long-latency EPSPs (100-300 ms) in slices from @entity1 as young as 8 mo. Reflected EPSPs at very long and variable latencies (500-1,100 ms) and repetitive @entity302 could be evoked synchronously in pairs of cells. @entity2227 activation of local presynaptic neurons elicited robust epileptiform events in recorded cells. This was seen in slices from @entity1 as young as 16 mo. 5. These data provide physiological evidence for the presence of local inhibitory and excitatory synaptic circuits in @entity1 neocortex at least as early as 11 and 8 mo, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Local synaptic circuits and @entity302 in slices of neocortex from XXXX with intractable @entity302 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients']

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate', 'Glutamate']

entities_list: @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA']

entities_list: @entity1027 :: ('MESH:D001640', 'Chemical') :: ['bicuculline', 'Bicuculline']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'epileptiform bursts']

entities_list: @entity4782 :: ('MESH:D019347', 'Chemical') :: ['potassium-acetate']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: PURPOSE: Efficacy and safety of topical application of a fibrin sealant (FS) compared with intravenous administration of @entity927 ( @entity928 ) for reducing @entity190 after @entity348 ( @entity348 ) is controversial. We undertook a meta-analysis to compare the effects of topical application of FS or intravenous administration of @entity928 on @entity190 after @entity348 . METHODS: PubMed, Medline, Embase, Web of Science and the Cochrane Library were searched to identify studies comparing FS with @entity928 for @entity348 @entity1 . The mean difference (MD) of @entity190 , hemoglobin value, and odds ratios (ORs) of transfusion requirements and adverse events in FS and @entity928 groups were pooled throughout the study. Relevant data were analyzed using RevMan v5.3. RESULTS: Five studies involving 359 @entity1 were included (181 FS vs. 178 @entity928 ). @entity928 use had a significantly lower prevalence of blood transfusion (OR = 3.14; 95% confidence interval (CI), 1.67 to 5.90, P = 0.0004) and higher hemoglobin level (MD = -1.23; 95% CI, -2.19 to -0.27, P = 0.01) than FS in the early postoperative period. No significant difference was seen in total @entity190 between the two groups (MD = 198.06; 95% CI, -267.45 to 663.57; P = 0.40). There were no significant differences in adverse events, superficial infections, or @entity1150 among study groups. CONCLUSIONS: Our meta-analysis suggests that intravenous administration of @entity928 for @entity1 undergoing @entity348 may reduce blood-transfusion requirements and maintain higher hemoglobin levels compared with topical application of FS in the early postoperative period. There were no significant differences in total calculated @entity190 and prevalence of complications between the two groups. However, owing to the variation of included studies, no firm conclusions can be drawn.

title: Topical fibrin sealant versus intravenous @entity927 for reducing @entity190 following XXXX : A systematic review and meta-analysis.

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep-vein thrombosis']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['total knee arthroplasty', 'TKA']

entities_list: @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid']

answer: @entity348 :: (MESH:C535338,Disease) :: ['total knee arthroplasty']


abstract: OBJECTIVE: The primary aim of the study was to analyze the @entity46 recurrence rate in @entity1 who underwent laparoscopic excision followed by postoperative long-term regimen of oral contraceptives (OCs). MATERIALS AND METHODS: 168 @entity1 who underwent a conservative laparoscopic surgery for @entity46 , during the period between September 2009 and August 2010 in three university hospitals were studied. A long-term OCs therapy was offered to all @entity1 following surgery. @entity1 were randomly divided into three groups according to different progestins used (desogestrel, @entity2081 , @entity18725 ). @entity1 who refused a postoperative hormonal therapy served as control. Follow-up visits and transvaginal scan were planned at 1, 3, 6, 12, and 24  months after surgery. All @entity1 who showed an ultrasound persistence of the @entity46 at 1  month follow-up were excluded from clinical analysis. RESULTS: Of the 168 @entity1 , 131 completed the 24  months follow-up. @entity46 recurrence was found in 21 (12.5  %) of all @entity1 , it was unilateral in 17 cases while bilateral in 4 cases. The rate of recurrent @entity46 was statistically significant in non-users compared to the long-term OCs treated @entity1 . CONCLUSION: The current data suggest the usefulness of long-term OCs regimen after conservative surgery for the prevention of @entity43 recurrence. As a statistical significant difference could not be observed between OCs groups, further study on the individual molecules is required in order to really understand the effect of each of them.

title: Oral contraceptives in the prevention of XXXX recurrence: does the different progestins used make a difference?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Women']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian endometrioma']

entities_list: @entity2081 :: ('MESH:C033273', 'Chemical') :: ['gestodene']

entities_list: @entity18725 :: ('MESH:C023635', 'Chemical') :: ['dienogest']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometrioma', 'Endometrioma']

answer: @entity46 :: (MESH:D004715,Disease) :: ['endometrioma']


abstract: The feasibility, safety and usefulness of @entity4341 echocardiography (two-dimensional echocardiography and 12 lead electrocardiographic monitoring during @entity4341 infusion, up to 0.84 mg/kg over 10 min) were evaluated in 94 asymptomatic @entity1 8 to 10 days after uncomplicated @entity583 . The results were compared with those of symptom-limited treadmill exercise testing and correlated with coronary angiography. Two mechanical patterns of positivity of @entity4341 echocardiography could be identified: 1) a new wall motion abnormality confined to the @entity1188 zone or to the adjacent segments (24 @entity1 ), and 2) transient remote asynergy (33 @entity1 ). The success rate in recording adequate images during @entity4341 infusion was 100%. Interobserver agreement concerning diagnosis occurred in 89 (93%) of 94 @entity1 . @entity4341 echocardiography was well tolerated; no complication was observed during or after the test. Seventy-three @entity1 underwent coronary angiography within 6 weeks after @entity583 . Transient remote asynergy on echocardiography was present in 27 of 40 @entity1 with multivessel disease and in none of 33 @entity1 without multivessel disease. Results of treadmill exercise testing were positive in 28 @entity1 with multivessel disease and 8 @entity1 without multivessel disease. Thus, the sensitivity of @entity4341 -induced transient remote asynergy was 68% compared with 52% for treadmill testing (p less than 0.05); specificity was 100% and 72%, respectively (p less than 0.005). The overall accuracy of @entity4341 echocardiography (81%) was higher than that of @entity4341 stress electrocardiography (63%) or exercise electrocardiography (60%) (p less than 0.02). It is concluded that @entity4341 echocardiography is a useful, feasible and inexpensive nonexercise-dependent test for detecting the extent of @entity453 early after @entity583 .

title: High dose XXXX echocardiography early after uncomplicated @entity583 : correlation with exercise testing and coronary angiography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4341 :: ('MESH:D004176', 'Chemical') :: ['dipyridamole', 'Dipyridamole']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

answer: @entity4341 :: (MESH:D004176,Chemical) :: ['dipyridamole']


abstract: AIM: To investigate whether presumed @entity3219 in the Netherlands is caused by @entity3218 and whether other risk factors might play a role in the pathogenesis of this syndrome. METHODS: 23 @entity1 were clinically diagnosed as having presumed @entity3219 based on the following criteria: peripapillary @entity194 , punched out lesions, a @entity75 or scar in one eye without vitritis. As controls, 66 sex and age matched healthy volunteers were used. Serum samples from both @entity1 and controls were tested for the presence of antibodies against @entity3218 , @entity3204 , @entity5603 et cati, Ascaris sp, and for the presence of antigens of Cryptococcus neoformans. Serum samples were also tested for the presence of autoantibodies against @entity989 . To investigate other risk factors, @entity1 and controls were asked to fill in a health and travel related questionnaire. Ten @entity1 with @entity17577 were used as a disease control group. RESULTS: None of the @entity1 with presumed @entity3219 or controls had circulating antibodies directed against @entity3218 . No risk factors could be identified and no indications for @entity792 and no evidence for the role of the other infectious agents could be demonstrated. CONCLUSIONS: In a Dutch group of @entity1 fulfilling the criteria of a disease currently named presumed @entity3219 , no risk factors or relation with the fungus @entity3218 could be detected.

title: Aetiological study of the presumed XXXX in the Netherlands.

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['macular disciform lesion']

entities_list: @entity5603 :: ('6265', 'Species') :: ['Toxocara canis']

entities_list: @entity17577 :: ('MESH:D014126', 'Disease') :: ['ocular toxoplasmosis']

entities_list: @entity3218 :: ('5037', 'Species') :: ['Histoplasma capsulatum', 'H capsulatum']

entities_list: @entity3219 :: ('MESH:D006660', 'Disease') :: ['ocular histoplasmosis syndrome']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal or choroidal proteins']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']

entities_list: @entity3204 :: ('5811', 'Species') :: ['Toxoplasma gondii']

answer: @entity3219 :: (MESH:D006660,Disease) :: ['ocular histoplasmosis syndrome']


abstract: @entity281 display variation patterns of clinical course and outcome. Although @entity1961 (+) @entity3783 (+) @entity3744 (+) regulatory T (Treg) cells play an essential role in immune homeostasis, the immune regulatory roles involved in @entity281 remains to be elucidated. Herein, we compared the disparity in Treg cells response during the course of blood stage @entity27571 @entity5427 (P. c chabaudi @entity5427 ) infection in DBA/2 and BALB/c @entity19 . BALB/c @entity19 initiated a @entity630 / @entity61 profile respond to P. c chabaudi @entity281 , but DBA/2 @entity19 failed to control P. c chabaudi @entity281 and almost of them died post-peak @entity5895 . At the peak @entity5895 , we found that higher proportion of Treg cells with elevated @entity3744 expression in DBA/2 than in BALB/c @entity19 . We used anti- @entity3783 mAb to deplete Treg cells and found that the survival time and rate were prolonged in DBA/2 @entity19 treated with anti- @entity3783 mAb. Treatment with anti- @entity3783 mAb in vivo led to enhanced pro- @entity32 responses and @entity3744 expression decline on Treg cells. In contrast, after DBA/2 was treatment with anti- @entity28785 mAb, @entity28785 blockade in vivo caused excessive pro- @entity32 responses and @entity3744 expression loss on @entity1961 (+) @entity3783 (+) T cells. Earlier @entity204 was found in all of DBA/2 mice with anti- @entity28785 mAb. It suggested that @entity2047 and @entity1618 signal involved in maintaining @entity3744 expression on Treg cells. In all, the moderate suppressive activity of Treg cells may facilitate resistance to P. c chabaudi @entity281 .

title: Plasmodium chabaudi XXXX : distinct @entity1961 (+) @entity3783 (+) @entity3744 (+) regulatory T cell responses during infection in DBA/2 and BALB/c @entity19 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Malaria infections', 'AS infection', 'malaria infection']

entities_list: @entity27571 :: ('31271', 'Species') :: ['Plasmodium chabaudi chabaudi']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemia']

answer: @entity5427 :: (MESH:D017204,Disease) :: ['AS']


abstract: OBJECTIVE: Causes of benign positional vertigo ( @entity15882 ) are mostly unknown. The aim of this study was to elucidate an association of @entity170 with idiopathic @entity15882 . METHODS: Two hundred nine consecutive @entity1 with a confirmed diagnosis of idiopathic @entity15882 underwent bone mineral densitometry of anterior-posterior lumbar spine and femur. The T scores were compared with those of 202 controls without a history of dizziness. Recurrence was defined when the @entity1 reported two or more previous episodes of positional vertigo similar to those experienced at the time of diagnosis. RESULTS: In both @entity1 and @entity1 , the lowest T scores were decreased in @entity1 with @entity15882 compared with those in controls. Furthermore, the prevalences of @entity2331 (-2.5 < T score < -1.0) and @entity170 (T score < or =-2.5) were higher in both @entity1 and @entity1 with @entity15882 than in controls. Multiple logistic regression analyses adjusted for age, sex, alcohol, smoking, and @entity2265 showed that only the existence of @entity2331 / @entity170 was associated with an increased risk of @entity15882 (adjusted odds ratio of @entity2331 = 2.0, 95% confidence interval 1.2-3.4, p = 0.011; adjusted odds ratio of @entity170 = 3.1, 95% confidence interval 1.4-7.2, p = 0.007). In @entity1 aged > or =45 years, the lowest T scores were also decreased in the recurrent group, compared with those in the de novo group. CONCLUSION: @entity2331 / @entity170 may be associated with @entity345 ( @entity15882 ). The effectiveness of measuring bone mineral densitometry and restoring normal @entity460 metabolism for preventing recurrences of @entity15882 requires further validation.

title: @entity2331 and XXXX in @entity345 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity345 :: ('MESH:D065635', 'Disease') :: ['idiopathic benign positional vertigo']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia', 'Osteopenia']

entities_list: @entity2265 :: ('MESH:D054559', 'Disease') :: ['hyperphosphatemia']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']


abstract: @entity25521 is a translation initiation factor that exhibits bidirectional RNA unwinding activity in vitro in the presence of another translation initiation factor, @entity9259 and @entity855 . This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukaryotic mRNAs to facilitate ribosome binding. @entity25521 is a member of a fast growing family of proteins termed the DEAD family. These proteins are believed to be RNA helicases, based on the demonstrated in vitro RNA helicase activity of two members ( @entity25521 and @entity31661 ) and their homology in eight @entity535 regions. Several related biochemical activities were attributed to @entity25521 : (i) @entity855 binding, (ii) RNA-dependent @entity4430 and (iii) RNA helicase. To determine the contribution of the highly conserved regions to these activities, we performed site-directed mutagenesis. First we show that recombinant @entity25521 , together with recombinant @entity9259 , exhibit RNA helicase activity in vitro. Mutations in the @entity4430 A motif (AXXXXGKT) affect @entity855 binding, whereas mutations in the predicted @entity4430 B motif (DEAD) affect @entity855 hydrolysis. We report here that the DEAD region couples the @entity4430 with the RNA helicase activity. Furthermore, two other regions, whose functions were unknown, have also been characterized. We report that the first residue in the HRIGRXXR region is involved in @entity855 hydrolysis and that the SAT region is essential for RNA unwinding. Our results suggest that the highly conserved regions in the DEAD box family are critical for RNA helicase activity.

title: Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

answer: @entity25521 :: (1973,Gene) :: ['eIF-4A']


abstract: Limited chymotryptic cleavage of @entity233 gizzard calponin yields a 13 kDa fragment which could be purified by its ability to bind to Sepharose-immobilized tropomyosin. This 13 kD polypeptide is shown to be derived from a 22 kDa fragment. Complete @entity535 sequence analysis of the 13 kD and 22 kD fragments reveals high homology with the formerly characterized smooth muscle-specific protein SM22 alpha (Pearlstone, J.R., Weber, M., Lees-Miller, J.P., Carpenter, M.R. and Smillie L.B., 1987, J. Biol. Chem. 262, 5985-5991) and the product of gene @entity33401 of @entity238 (Ayme-Southqate, A., Lasko, P., French, C, and Pardue, M.L. [(1989) J. Cell Biol. 108, 521-531]. Futhermore we recognize sequence elements of a putative actin-binding domain of alpha-actinin, the calpactin I or p 36 sequence, and a consensus motif present in the repeats of the gene product of the candidate @entity33402 gene of @entity2199 (S.D. Goetinck and R.H. Waterston, personal communication).

title: Isolation and sequence of a tropomyosin-binding fragment of XXXX gizzard calponin.

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity233 :: (9103,Species) :: ['turkey']


abstract: OBJECTIVES: Obesity prevalence has increased in Iranian adolescents in recent years. However, few studies have examined the impact of intervention programs on this health issue. The main objective of this study was to evaluate the effects of 8-week endurance training (ET) and @entity2101 ( @entity2101 ) on intercellular adhesion molecule-1( @entity2071 ) and vascular adhesion molecule-1( @entity4725 ) levels among @entity28 and normal-weight male adolescents. METHODS: Thirty @entity28 and 30 normal-weight subjects were assigned to the ET, @entity2101 , or control group for eight weeks. Before and after the intervention, @entity2071 , @entity4725 , body weight, BMI, VO2max, and blood pressures were measured. SPSS (Version 21) was used for data analysis, and the significance level was set at p  <  0.05. RESULTS: Mixed design ANOVAs indicated that the @entity28 @entity1 had significantly (p  <  0.05) lower @entity2071 levels in the ET (from 509      61  ng/ml to 387      43  ng/ml) and @entity2101 (from 517      72  ng/ml to 374      50  ng/ml), but their @entity4725 level was significantly (p  <  0.05) reduced only after the @entity2101 (from 1689      119  ng/ml to 1282      63  ng/ml). Similarly, normal weight @entity1 significantly (p  <  0.05) lowered their @entity2071 levels in the ET (from 296      18  ng/ml to 216      14  ng/ml) and @entity2101 (from 289      22  ng/ml to 202      12  ng/ml), but their @entity4725 level was significantly (p  <  0.05) reduced only after the @entity2101 (from 895      50  ng/ml to 673      142  ng/ml). Systolic blood pressure and diastolic blood pressures of all the @entity1 were significantly (p  <  0.01) decreased at the conclusion of the ET and @entity2101 . CONCLUSION: While both the ET and @entity2101 were useful in lowering the @entity13519 and @entity13520 of the @entity1 , @entity2101 was more effective than ET in reducing @entity2071 and @entity4725 content in normal and @entity28 adolescents.

title: Effects of endurance and high intensity training on XXXX and @entity4725 levels and arterial pressure in @entity28 and normal weight adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity2101 :: ('MESH:C538394', 'Disease') :: ['high intensity interval training', 'HIIT']

answer: @entity2071 :: (3383,Gene) :: ['ICAM-1']


abstract: PURPOSE:: The aim of the study was to investigate the image quality of dual-energy computed tomography angiography (DECTA) using the @entity3466 ( @entity3466 ) technique to diagnose @entity438 . MATERIALS AND METHODS:: Eighty @entity1 with a suspected @entity438 were randomly assigned to undergo DECTA with @entity3466 (ie, @entity3466 -DECTA) or DECTA without @entity3466 (ie, DECTA). The objective image quality of these 2 groups was compared with digital subtraction angiography and surgical results as the reference. The location, number, and morphology of the @entity439 were evaluated between the 2 groups. The display degree and the size of aneurysmal neck and the diameters (ie, long and @entity851 ) of the @entity439 were compared between the 2 groups. RESULTS:: The signal-to-noise ratio and contrast-to-noise ratio of @entity3466 -DECTA were significantly higher than those of DECTA (P<0.05). The difference between the 2 groups in @entity1504 subjective scoring was not statistically significant (P>0.05). In 30 of the 40 @entity1 in the @entity3466 -DECTA group, an @entity439 was detected without misdiagnosis or missed diagnosis. The @entity439 location, @entity439 number, and measurements by the 2 methods were closely correlated without significant statistical differences (the R values were 0.953, 0.982, and 0.974, respectively; P=0.000). The detection rate was 93% (26/28 @entity1 ). In the DECTA group, 2 @entity1 were misdiagnosed. Mean long and short diameter and neck size by three-dimensional digital subtraction angiography were 5.82  3.27, 4.67  3.31, and 3.29  1.38mm, respectively. @entity439 locations, number, and neck size by the 2 methods were closely correlated without a significant statistical difference (R values were 0.964, 0.968, and 0.856, respectively; P=0.000). CONCLUSIONS:: The @entity3466 -DECTA is very accurate for diagnosing @entity438 and could be a routine noninvasive screening method.

title: Application Value of Selective Photon Shield in Dual-Energy Computed Tomography Angiography for Diagnosis of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['short axis']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial vascular']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'Aneurysm']

entities_list: @entity3466 :: ('MESH:D003784', 'Disease') :: ['selective photon shield', 'SPS']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysm', 'intracranial aneurysms']

answer: @entity438 :: (MESH:D002532,Disease) :: ['Intracranial Aneurysms']


abstract: BACKGROUND: @entity1582 is an incurable @entity5 . Since the late 1990s, its management has changed with the introduction of novel agents. @entity2816 , which is often called a "novel" therapy, has significantly prolonged survival in @entity1582 and is considered worldwide to be part of standard of care in this disease. However, @entity2816 is not approved in Canada, leading to problems with drug access for @entity1 . METHODS: Our study surveyed Canadian hematologists on their @entity2816 prescribing practices and difficulties with drug access. We address some of the ethical issues facing @entity1 and their doctors who are unable to obtain or afford the drug, and who therefore resort to alternative means such as illegal importation. RESULTS: Of the 411 Canadian hematologists contacted, 122 completed the survey, 97 reported that they did not treat @entity1582 , and 192 did not respond. Assuming that all non-responders treat @entity1582 , our estimated overall response rate from physicians who treat this disease was 39%. Survey @entity1 indicated that, in Canada, access to @entity2816 is a major issue for physicians and @entity1582 @entity1 alike, and that 81% of respondents are dissatisfied or very dissatisfied with the drug access process. Many physicians felt that the special access process for @entity2816 is unduly onerous, influences treatment decisions, and invades @entity1 privacy. We found that 20% of physicians were unaware of the legal implications of obtaining @entity2816 from other countries and that at least 23% overtly or covertly support @entity1 in obtaining the drug from a non-Health-Canada-approved source. CONCLUSIONS: The current lack of access to @entity2816 in Canada is a concerning problem for @entity1 and health care providers dealing with @entity1582 . Regulatory changes at the federal level (Health Canada) need to be re-examined to promptly resolve this issue.

title: Access to XXXX for the treatment of @entity1582 in Canada: physician behaviours and ethical implications.

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'myeloma', 'Multiple myeloma']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['Thalidomide', 'thalidomide']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

answer: @entity2816 :: (MESH:D013792,Chemical) :: ['thalidomide']


abstract: Lymphocytes infiltrating @entity1 @entity43 obtained directly from the @entity5 mass ( @entity5 -infiltrating lymphocytes, TIL) or from the @entity843 ( @entity5 -associated lymphocytes, @entity26076 ) were expanded in vitro in long-term cultures with @entity1199 and tested for their specific cytolytic activity. Killing of the @entity5 was detected only in a proportion of the @entity1 , less frequently in TIL compared to @entity26076 . In fact two out of ten TIL and four out of nine @entity26076 cultures tested showed significant levels of lysis against the @entity5 . This cytotoxic activity was not restricted to the @entity5 , as other @entity5 cell lines, including @entity43 , were lysed as well. The cultures that were not cytotoxic against the @entity5 were in most cases able to lyse other @entity5 cell lines of ovarian or other histology. Cloning of TIL from one @entity1 was performed: of 22 clones tested, 4 displayed higher @entity137 against the @entity5 compared to the uncloned population and 3 out of these 4 did not kill an irrelevant @entity189 cell line. In order to stimulate the expansion of putative specific effectors we performed mixed lymphocyte/ @entity5 cultures (MLTC) with autologous or allogeneic @entity5 cells. No stimulation of @entity137 against the @entity5 was detected after MLTC in nine different @entity26076 populations, using autologous or allogeneic @entity5 as stimulators. On the contrary, peripheral blood lymphocytes from two @entity1 after MLTC with the @entity5 showed increased killing of the autologous and decreased killing of an allogeneic target. In conclusion TIL and @entity26076 from @entity43 expanded in vitro with @entity1199 usually have non-MHC-restricted @entity137 and variable degrees of reactivity against the @entity5 . A preferential killing for the @entity5 was not observed even after MLTC. These results do not exclude the existence of @entity5 -specific cytotoxic T lymphocytes in @entity43 ; nevertheless they suggest that putative specific effectors have very low frequency and that culture techniques for expanding their growth more selectively are still to be optimized.

title: In search of specific cytotoxic T lymphocytes infiltrating or accompanying XXXX @entity43 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'non-ovarian ones']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['autologous tumour', 'tumours', 'tumour']

entities_list: @entity843 :: ('MESH:D001201', 'Disease') :: ['carcinomatous ascites']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: 1 A lymphocyte culture method has been developed for studying in vitro the effect of prolonged exposure (24 h) to @entity3044 (10(-8) to 10(-6) mol/l) and @entity5015 ( @entity5015 ; 2.8 x 10(-6) mol/l). 2 The @entity1919 response to @entity3044 is reduced by prolonged exposure to @entity3044 . The degree of desensitization is in proportion to the concentration of @entity3044 in the culture medium. 3 Culture with @entity3044 does not reduce the @entity1919 response to @entity5015 . 4 Culture for 24 h with @entity5015 (2.8 x 10(-6) mol/l) reduces the @entity1919 response to @entity5015 . It also significantly reduces the response to @entity3044 . 5 Lymphocytes from @entity748 @entity1 show a similar degree of desensitization to @entity3044 (after 24 h culture with @entity3044 ) to that seen in lymphocytes from normal subjects. 6 A modified assay for phosphodiesterase (PDE) activity was developed. PDE activity increased 24.5% (P less than 0.02) after culture with @entity5015 but was not significantly affected by culture with @entity3044 . 7 It is concluded that desensitization caused by prolonged exposure to various stimulators of adenylate cyclase is an event dependent on several components, not all of which are yet defined.

title: Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and @entity748 XXXX in vitro.

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1', 'PGE1']

entities_list: @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoprenaline']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Onychophagia can be explained as a kind of a compulsion that may cause destruction of the nails. Habitual nail biting is a common behaviour among @entity1 and young adults. By the age of 18 years the frequency of this behaviour decreases, but it may persist in some adults. Nail biting is an under-recognized problem, which may occur on a continuum ranging from mild to severe. Nail biting has received little attention in the @entity146 and dermatological literature. Its position in widely accepted classifications of @entity146 ( @entity1479 -10 and DSM-IV) remains unclear. This disorder seems to be related to @entity3119 . Here, we present three case reports of onychophagia and co-occurring psychopathological symptoms and discuss the close relationship of onychophagia to @entity3119 and possible treatment modalities. Psychiatric evaluation of co-occurring psycho pathological symptoms in @entity1 with onychophagia, especially those with chronic, severe or complicated nail biting, may be helpful in making a choice of individual therapy. @entity750 re-uptake inhibitors seem to be the treatment of choice in severe onychophagia.

title: Onychophagia as a spectrum of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['Serotonin']

entities_list: @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive- compulsive spectrum disorder', 'obsessive-compulsive spectrum disorder']

answer: @entity3119 :: (MESH:D009771,Disease) :: ['obsessive-compulsive disorder']


abstract: Sclerostin monoclonal antibody (Scl-Ab) has been shown to increase bone mass and bone strength by stimulating bone formation in an ovariectomy-induced @entity604 @entity35 model. The purpose of this study was to determine the effects of Scl-Ab in a @entity35 immobilization/disuse model in which there was both a decrease in bone formation and an increase in bone resorption. Ten-month-old female @entity35 were divided into normal weight-bearing (normal-loaded, NL) and right hindlimb-immobilization (under-loaded, UL) groups. Both NL and UL @entity35 were treated with vehicle or Scl-Ab at 5 or 25 mg/kg, twice per week for 4 weeks. Trabecular and cortical bone histomorphometric analyses were performed on the proximal tibial metaphysis (PTM) and @entity4957 ( @entity4957 ). Compared to NL controls, UL @entity35 had reduced body and muscle weights, increased bone marrow fat cells in the PTM, increased trabecular bone resorption and periosteal mineral apposition rate (MAR) as well as decreased trabecular MAR and bone formation rate (BFR/ @entity10673 ). In NL bones, treatment with Scl-Ab significantly increased bone formation and decreased bone resorption, resulting in increased trabecular and cortical bone mass. In UL trabecular bone, treatment with Scl-Ab at 5 or 25 mg/kg induced significant and dose-dependent increases in trabecular bone volume and thickness, mineralized surfaces ( @entity15 / @entity10673 ), MAR and BFR/ @entity10673 , and a significant decrease in eroded surface (Er.S/ @entity10673 ) compared with UL controls. In UL cortical bone, Scl-Ab treatment induced significant increases in cortical width, periosteal and endocortical @entity15 / @entity10673 , MAR and BFR/ @entity10673 , and significant decreases in endocortical Er.S/ @entity10673 compared with UL controls. Taken together, these findings suggest that antibody-mediated blockade of sclerostin represents a promising new therapeutic approach for the anabolic treatment of immobilization-induced @entity2331 .

title: Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization XXXX model.

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity4957 :: ('MESH:D020429', 'Disease') :: ['TS', 'tibial shaft']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats', 'rats']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES: @entity1 with @entity991 ( @entity991 ) have an increased risk for @entity1086 . We aimed to define the postoperative outcomes in @entity991 @entity1 after cholecystectomy and determine if size of a @entity1085 on imaging predicts the presence of @entity5 . METHODS: We conducted a retrospective review of @entity1 with @entity991 who underwent cholecystectomy at Mayo Clinic between 1 January 1995 and 31 December 2008. @entity1 with a prior history of a liver transplant or @entity201 were excluded. RESULTS: A total of 57 @entity1 were included in our primary analysis during the early postoperative period. The most common indication for undergoing a cholecystectomy was the presence of a @entity1127 or mass. The sensitivity and specificity of a @entity1085 of 0.80   cm and the presence of @entity1085 was 100% (95% confidence interval (CI) 77-100%) and 70% (95% CI 35-93%), respectively. Of the @entity1 , 23 (40%) had an early @entity260 . The @entity1 -Pugh score was the only predictor of postoperative outcomes in the multivariate model (odds ratio 1.78, 95% CI 1.11-3.12, P=0.02). CONCLUSIONS: Cholecystectomy in @entity1 with @entity991 is associated with a high morbidity. @entity1127 <0.80   cm are unlikely to be malignant and observation of these small @entity1127 should be considered. A higher @entity1 -Pugh score was associated with early @entity260 .

title: Likelihood of XXXX in @entity1127 and outcomes following cholecystectomy in @entity991 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients']

entities_list: @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder neoplasia', 'gallbladder lesion']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['gallbladder polyp', 'Gallbladder polyps', 'polyps']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity991 :: ('MESH:D015209', 'Disease') :: ['PSC', 'primary sclerosing cholangitis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'postoperative complication']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma']

entities_list: @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancy']


abstract: @entity28 is a grave issue, which needs to be addressed urgently because it leads to several medical and psychosocial problems in @entity1 . High prevalence is being increasingly reported in @entity1 from developing countries as well. The combination of our genetic propensity to store fat, the ready availability of calorie dense foods, and sedentary lifestyle promotes overweight. The @entity1 's food environment at home and parental @entity28 are strong determinants. Urban poor in developed countries and urban rich in developing countries are both at risk. In developing countries, a number of beliefs passed down over generations are other important determinants. Evaluation includes assessing the @entity1 's lifestyle, excluding weight-promoting medication history; poor linear growth needs endocrine evaluation; @entity74 should be considered if there are clinical pointers. Overweight @entity1 should be evaluated for @entity101 , @entity2299 , T2DM, and @entity1561 . Therapeutic lifestyle changes targeting food habits and physical activity through parental participation and social support are the cornerstones of preventing @entity28 . Active travel and play by making the built environment more accessible, ban on 'junk' food advertising, and effective health education through active participation of clinicians, school systems, and the media will go a long way in reversing anticipated trends in @entity28 .

title: XXXX : Determinants, evaluation, and prevention.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['childhood obesity', 'Childhood obesity', 'obesity']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic syndromes']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Childhood obesity']


abstract: BACKGROUND _ AIMS: It is established that cirrhotic @entity1 who respond to beta-blockers by lowering their @entity99 ( @entity99 ) to < or =12 mmHg or by > or =20% of the baseline values are protected from bleeding. However, it is not known whether the effect remains unchanged over the treatment period. METHODS: A group of 24 @entity1 with @entity82 and oesophageal varices, treated with beta-blockers+/- @entity3362 , good-responders on haemodynamic criteria, were followed for up to 76 months with sequential @entity99 measurements. Another group of 16 @entity1 was used for validation. RESULTS: @entity99 worsened in 10 of the 24 @entity1 during follow-up. Changes in @entity99 correlated to concomitant changes in liver function parameters. @entity548 occurred in four of the 10 @entity1 whose @entity99 had worsened (bleed; 3-21 months after the measured increase in @entity99 ) and in none of those with stable @entity99 (p=0.02). @entity1 with increased @entity99 also had shorter survival (p=0.05). Worsening of @entity99 was an independent predictor of @entity204 , additive to @entity1 -Pugh or MELD scores, in a time-dependent Cox's regression analysis. This relationship was confirmed in the validation group. CONCLUSIONS: Worsening @entity99 during follow-up in @entity1 who had initially been good-responders to medical treatment is related to worsening in hepatic function. The maintenance of a good haemodynamic response to medical treatment of portal @entity101 is an excellent predictor of outcome in these @entity1 .

title: Clinical significance of worsening portal XXXX during long-term medical treatment in @entity1 with @entity82 who had been classified as early good-responders on haemodynamic criteria.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Variceal bleeding']

entities_list: @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['HVPG', 'hepatic venous pressure gradient']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Sixty-four @entity1 were entered into a randomized trial that evaluated intra-arterial (I.A.) versus intravenous (I.V.) @entity10049 (FUDR) for colorectal liver metastases. There was a significant improved response rate for I.A. (62%) compared with I.V. (17%) treatment (p less than 0.003). However, the improved response rate for @entity1 in whom I.A. therapy was used did not translate to a significantly improved survival rate. The 2-year actuarial survival rates for the groups for which I.A. and I.V. therapy was used were 22% and 15% respectively, with the survival curves not differing significantly (p = 0.27). These results may have been due to the inclusion of @entity1 with @entity5 in draining hepatic lymph nodes. The presence of @entity5 in hepatic lymph nodes was associated with a poorer prognosis. Analysis of a subgroup of @entity1 with negative hepatic lymph nodes suggested an improved actuarial survival rate in @entity1 for whom I.A. versus I.V. therapy was used (p less than 0.03). The @entity137 of I.A. FUDR was considerable, and side effects included chemical @entity99 (79%), @entity253 (21%), peptic ulcers (17%), and @entity3621 / @entity9317 (21%). The only major effect of @entity137 of I.V. FUDR was severe @entity294 (59%). Regional I.A. FUDR allowed more @entity99 , which resulted in increased @entity5 responses when compared with use of systemic therapy. However, the small gain in survival seen in a select subgroup of @entity1 with negative hepatic nodes appeared to be offset by the @entity137 of I.A. FUDR.

title: A prospective randomized trial of regional versus systemic continuous XXXX chemotherapy in the treatment of colorectal liver metastases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity10049 :: ('MESH:D005467', 'Chemical') :: ['5-fluorodeoxyuridine']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary sclerosis']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['drug delivery to liver tumors', 'hepatitis']

entities_list: @entity9317 :: ('MESH:D004382', 'Disease') :: ['duodenitis']

answer: @entity10049 :: (MESH:D005467,Chemical) :: ['5-fluorodeoxyuridine']


abstract: We report the cases of two @entity1 with @entity1151 and @entity1576 after @entity5852 . Hysterectomy was performed in both @entity1 after unsuccessful uterine curettage and antibiotic therapy for treatment of the @entity281 . The first @entity1 (27 years-old) remained feverish. The blood cultures yielded @entity794 . @entity1145 was identified as the reason for persistent @entity281 . Antibiotic treatment properly planned was administered and the @entity1 was discharged. The second @entity1 (23 years-old) apparently recovered after hysterectomy. Nevertheless, one month later, @entity281 and @entity1151 recurred. The diagnosis of @entity794 @entity1145 was made. @entity281 unresponsive to medical treatment led to surgical treatment. The @entity1 died after valve replacement. Thus the persistence or recurrence of @entity5852 may be due to @entity1145 .

title: [ XXXX and endocarditis caused by @entity794 in the tricuspid valve after infectious abortion. Report of 2 cases].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5852 :: ('MESH:D000031', 'Disease') :: ['septic abortion', 'infection and septic abortion']

entities_list: @entity1145 :: ('MESH:D018785', 'Disease') :: ['Tricuspid valve endocarditis', 'tricuspid valve endocarditis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['septic pulmonary embolism']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'Persistent infection']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

answer: @entity1151 :: (MESH:D011655,Disease) :: ['Septic pulmonary embolism']


abstract: BACKGROUND: @entity5 is one of the highly virulent diseases known to humankind with a high mortality rate. @entity0 is the most common @entity5 in @entity1 worldwide. @entity1101 is a principal cereal food in many parts of the world, and is critical in folk medicine of Asia and Africa. In the present study, we analyzed the effects of @entity6507 in metastatic @entity0 . METHODOLOGY/PRINCIPAL FINDINGS: Preliminary studies conducted on MDA-MB 231 and MCF-7 xenograft models showed @entity5 growth suppression by @entity6507 . Western blotting studies conducted both in vivo and in vitro to check the effect of @entity6507 in Jak/STAT pathways. Anti-metastatic effects of @entity6507 were confirmed using both MDA-MB 231 and MCF-7 metastatic animal models. These studies showed that @entity6507 can modulate Jak/STAT pathways, and it hindered the STAT5b/IGF-1R and STAT3/VEGF pathways not only by down-regulating the expression of these signal molecules and but also by preventing their phosphorylation. The expression of angiogenic factors like VEGF, VEGF-R2 and cell cycle regulators like cyclin D, cyclin E, and pRb were found down-regulated by @entity6507 . In addition, it also targets Brk, p53, and HIF-1a for anti- @entity5 effects. @entity6507 induced G1 phase arrest and migration inhibition in MDA-MB 231 cells. The @entity3 of @entity0 to the lungs also found blocked by @entity6507 in the metastatic animal model. CONCLUSIONS/SIGNIFICANCE: Usage of HS as a dietary supplement is an inexpensive @entity5 therapy, without any side effects. We strongly recommend the use of HS as an edible therapeutic agent as it possesses @entity5 suppression, migration inhibition, and anti-metastatic effects on @entity0 .

title: Hwanggeumchal XXXX induces cell cycle arrest, and suppresses @entity5 growth and @entity3 through Jak2/STAT pathways in @entity0 xenografts.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'natural cancer', 'cancer', 'Cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1101 :: (4558,Species) :: ['sorghum']


abstract: BACKGROUND: Shoulder subluxation is a frequent occurrence in individuals following a @entity64 . Although various methods of treatment are available, none of them address all possible consequences of the @entity158 , limited range of motion, the subluxation, and decreased functional use of the arm. AIMS: The purpose of this study was to evaluate the effectiveness of California tri-pull taping (CTPT) method on shoulder subluxation, @entity158 , active shoulder flexion, and upper limb functional recovery after @entity64 . MATERIALS AND METHODS: This was a randomized control study on 30 @entity1 . All @entity1 received conventional neurorehabilitation 5 days a week over 6 weeks. Half of the @entity1 also received the CTPT. Pre- and post-assessment scores were taken on all @entity1 for the amount of shoulder subluxation, @entity158 , active shoulder flexion, and functional recovery. RESULTS: The CTPT method demonstrated a significant @entity158 in the treatment group from baseline, a significant improvement in active shoulder flexion and a significant improvement in proximal arm function as measured on the proximal subscale on the Fugl-Meyer upper extremity functional Scale but not the distal or total Fugl-Meyer subscales. Shoulder subluxation was not statistically significant. CONCLUSIONS: The CTPT method is an effective treatment for the hemiplegic subluxed shoulder.

title: The California Tri-pull Taping Method in the Treatment of Shoulder Subluxation After XXXX : A Randomized Clinical Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['subluxation pain', 'pain', 'reduction of pain']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: Forty @entity1 with previous @entity583 were given 4 capsules with 1 g concentrated fish oil preparation daily for 4 weeks. No special diet was applied. The supplementation was equivalent to 3.4 grams of @entity7784 ( @entity8393 ) and @entity4600 ( @entity4601 ) daily. Twenty-two of the 40 subjects received concomitant treatment with long-term oral anticoagulants (OAC). The @entity844 composition of serum after the supplementation period showed a significant increase in the proportion of @entity8393 and @entity4601 , while @entity1426 (AA) remained essentially constant. This resulted in a rise of the @entity8393 /AA ratio from 0.59 to 1.49 (p less than 0.001), confirming satisfying absorption of the concentrate. Blood lipids showed an overall decrease of @entity1674 (TG) by 25% (p = 0.02), while total @entity165 rose by 5% (p = 0.03) and HDL- @entity165 was unaffected. Blood @entity413 and the TG associated factors plasminogen activator inhibitor and factor VII-phospholipid complex revealed trends towards reduction. Ivy bleeding time showed a significant prolongation, the median increasing from 240 to 270 seconds. A significant increase of @entity2002 was seen, as was a decrease of clotting time in the combined prothrombin test in @entity1 receiving concomitant OAC. Thus, given for 4 weeks, the investigated concentrate of @entity9539 exerts not merely beneficial effects as far as the risk profile for @entity731 is concerned. The results also point towards interactions with OAC that may be of clinical relevance.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influence of highly concentrated @entity9539 on serum lipids and hemostatic variables in survivors of XXXX receiving either oral anticoagulants or matching placebo.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic disease']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity9539 :: ('MESH:D015525', 'Chemical') :: ['n-3 fatty acids']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: We investigated the effect of prolonged @entity11081 ( @entity11081 ) receptors blockade on the constrictor response to @entity2647 and the dilator response to @entity934 ( @entity1617 ) in isolated aortic rings from normotensive [ @entity35 -Kyoto (WKY)] @entity35 and spontaneously @entity101 @entity35 (SHRs). Animals were treated for 2 weeks with the @entity11081 -receptor blocker @entity32593 (50 mg/kg/day; n = 8). @entity32593 treatment did not affect blood pressure in both strains. In isolated aortic segments, dilation to @entity1617 and contractions to @entity2647 were decreased only in SHRs. @entity842 (NO) synthesis blockade (L-NAME, 0.1 mM) inhibited 90+/-11% (WKY @entity35 ) and 76+/-8% (SHRs) of @entity1617 -induced dilation. Cyclooxygenases blockade ( @entity3352 , 10 microM) had no effect in both strains. Endothelium-derived hyperpolarizing factor(s) (EDHF) blockade (KCl, 20 mM) suppressed the remaining @entity1617 -induced dilation in both strains. Treatment with @entity32593 significantly decreased NO-dependent dilation, as compared with controls [70+/-8% vs. 90+/-11% (WKY @entity35 ) and 54+/-6% vs. 76+/-8% (SHRs) of total dilation; p<0.05]. On the other hand, @entity32594 -dependent dilation was significantly higher in the @entity32593 groups [29+/-5% vs. 10+/-3% (WKY @entity35 ) and 44+/-7% vs. 19+/-4% (SHRs) of total dilation; p<0.05]. Thus prolonged @entity11081 -receptor blockade decreased the responsiveness to @entity2647 and @entity1617 in SHR aortas and changed the proportion of dilator agents in @entity1617 -induced dilation.

title: Prolonged blockade of endothelin XXXX receptors decreases vascular reactivity in the aorta of spontaneously @entity101 @entity35 in vitro.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity11081 :: (24326(Tax:10116),Gene) :: ['ET(A)']


abstract: BACKGROUND: @entity4929 ( @entity4929 ) of the @entity788 is often found with distinct @entity1124 ( @entity1124 ) in the same @entity788 . The aim of this study was to clarify whether endoscopic retrograde pancreatography (ERP) would be useful for the early detection of concomitant PDACs in @entity1 with IPMNs. METHODS: Medical records of 179 @entity1 who were histologically confirmed to have IPMNs after resection between 1987 and 2011 were reviewed. The @entity1 having concomitant PDACs were selected, and the diagnostic abilities to detect concomitant PDACs of computed tomography (CT), magnetic resonance imaging (MRI), endoscopic ultrasonography (EUS), and ERP were compared between early (stages 0-I according to Japanese General Rules for @entity788 ) and advanced (stages II-IV) PDACs. RESULTS: A total of 23 PDACs developed synchronously or metachronously in 20 @entity1 , and the prevalence of PDACs concomitant with IPMNs was 11.2 % (20/179). Sensitivities of CT (16 vs. 87 %), MRI (29 vs. 93 %), and EUS (29 vs. 92 %) in the early group were significantly lower than those in the advanced group (p < 0.01). On the other hand, the sensitivity of ERP in the early group was as high as that in the advanced group (86 vs. 82 %, respectively, p > 0.99). Among 7 early PDACs, 3 were diagnosed only by ERP. CONCLUSIONS: ERP has an important role in the early diagnosis of distinct PDACs in @entity1 with IPMNs. Further investigation is necessary to clarify the indication and the timing of ERP during management of IPMNs in term of early detection of concomitant PDACs.

title: Role of endoscopic retrograde pancreatography for early detection of XXXX concomitant with @entity4929 of the @entity788 .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreas', 'Pancreatic Cancer']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['Intraductal papillary mucinous neoplasm', 'IPMN']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['PDAC', 'pancreatic ductal adenocarcinoma']

answer: @entity1124 :: (MESH:D021441,Disease) :: ['pancreatic ductal adenocarcinoma']


abstract: This clinico-pathologic study of primary @entity1822 and analysis of potential prognostic factors involved a literature review of 64 cases and a report of four cases treated in the authors' unit. The demographic details, clinical presentation, diagnosis, treatment and outcome were documented for the whole group and clinico-pathologic variables analysed to detect potential prognostic factors. The most common presentation was that of a painless mass, with peak incidence in the 6th decade and a slight male predeliction (M:F=1.3:1). The maxilla was the most frequently involved site, followed by the mandible and tongue. Surgical excision was most commonly employed with radiotherapy and chemotherapy being reserved for recurrent and @entity5 . Local recurrence (34%) and @entity3 (35%) were not uncommon and occurred most frequently to the lungs and regional lymph nodes (15%). Age, sex, size and mitotic index were not statistically related to recurrence or @entity3 . Site (P=0.0125) was a predictor of @entity3 . @entity3 (P=0.010) and lesions involving the maxilla and mandible (P=0.019) were associated with decreased survival. The estimated 5 year survival was 55% for the whole group and 43% and 19% for @entity1 with bony involvement and @entity3 respectively.

title: Primary XXXX : a clinico-pathologic study and analysis of prognostic factors.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['metastatic tumours']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['oral leiomyosarcomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis']

answer: @entity1822 :: (MESH:D007890,Disease) :: ['oral leiomyosarcoma']


abstract: Clinical data on optimal management of mechanical complications of @entity583 are lacking. We retrospectively evaluated the effect of intra-aortic balloon pump (IABP) on 30-day survival in @entity1 with postinfarction @entity9009 ( @entity9009 , n  = 55) or @entity339 ( @entity339 , n  = 26) who developed either @entity1455 (n  = 46) or severe hemodynamic instability that did not fulfill the criteria of @entity1457 (n  = 35). IABP was inserted in 83% of the @entity1 with @entity1457 and 57% of those without @entity1457 . Thirty-five (76%) @entity1 with @entity1457 and all unstable @entity1 survived until surgical repair, which was performed within a median (interquartile range) of 1 (1 to 2) and 9 (2 to 18) days from the onset of the complication (p <0.001). All @entity1 who did not undergo the operation died within 3  days. Although @entity339 presented more acutely, the @entity1 ' outcomes were similar to those with @entity9009 . IABP support reduced 30-day mortality in the @entity1 with @entity1457 (61% vs 100%, p  = 0.04) but not in the @entity1 without @entity1457 (20% vs 27%, p  = 0.7). The benefit of IABP support in the @entity1457 cohort was driven mainly by reduction of preoperative mortality (11% vs 88%, p <0.001). Early progression of @entity1455 and unperformed surgery were the only independent predictors of 30-day mortality (hazard ratio 3.4, 95% confidence interval 1.5 to 8 and hazard ratio 5.1, 95% confidence interval 2.2 to 11, respectively; p  = 0.004 and p <0.001, respectively). In conclusion, we suggest that all @entity1 with postinfarction @entity9009 or acute @entity339 with signs of @entity1455 should immediately receive IABP as a bridge to emergent surgical repair. In contrast, hemodynamically unstable @entity1 without @entity1457 may be first stabilized by medical therapy, without additional benefit of IABP, before they undergo cardiac surgery.

title: Utility of intra-aortic balloon pump support for @entity9009 and @entity339 complicating acute XXXX .

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['acute mitral regurgitation', 'MR']

entities_list: @entity9009 :: ('MESH:D018658', 'Disease') :: ['VSR', 'ventricular septal rupture']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: Alterations in various developmental pathways are common themes in @entity5 . The early B-cell factors (EBF) are a family of four highly conserved DNA-binding transcription factors with an atypical @entity219 -finger and helix-loop-helix motif. They are involved in the differentiation and maturation of several cell lineages including B-progenitor lymphoblasts, neuronal precursors, and osteoblast progenitors. During B-cell development, @entity31493 is required for the expression of @entity5953 , an essential factor for the production of antibody-secreting cells. Accumulating evidence indicates that genomic deletion of the @entity31493 gene contributes to the pathogenesis, drug resistance, and relapse of @entity981 ( @entity981 ). Epigenetic silencing and genomic deletion of the @entity31494 locus in chromosome 10q are very frequent in @entity463 ( @entity463 ). Strikingly, the frequency of @entity31494 loss in @entity463 is similar to that of the loss of @entity983 , a key suppressor of gliomagenesis. Cancer-specific somatic mutations were detected in @entity31494 in @entity463 and in both @entity31493 and @entity31494 in @entity1124 . These missense mutations occur in the DNA-binding domain or the conserved IPT/TIG domain, suggesting that they might disrupt the functions of these two proteins. Functional studies revealed that @entity31494 represses the expression of genes required for cell proliferation [e.g., cyclins and cyclin-dependent kinases (CDK)] and survival (e.g., @entity2423 and @entity10206 ) but activates those involved in cell cycle arrest (e.g., @entity3544 and @entity993 ), leading to growth suppression and apoptosis. Therefore, EBFs represent new @entity5 suppressors whose inactivation blocks normal development and contributes to tumorigenesis of diverse types of @entity1 @entity5 .

title: Emerging roles of the EBF family of transcription factors in XXXX suppression.

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'B-progenitor acute lymphoblastic leukemia']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['pancreatic ductal adenocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma', 'GBM']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: OBJECTIVE: To identify factors associated with YMDD mutation in @entity1 with @entity6194 before and after @entity16332 treatment in Zunyi region. METHODS: 53 @entity1 with @entity6194 were enrolled in this study, @entity97 DNA, @entity97 markers, ALT, AST, TBil, albumin in the serum were examined at 0, 3, 6, 12, 18 and 24 months after @entity16332 treatment. @entity97 genotype and YMDD mutation were determined by sequencing before @entity16332 treatment. YMDD mutation was checked again if serum HBV DNA rebound to more than 1 x 10(4) copies/ml after the initial decrease. RESULTS: @entity97 genotype in Zunyi region is constitute of B, C and B+C genotype. YMDD mutation occurred in 18 cases after @entity16332 treatment, the rate of YMDD mutation was 15.1%, and 34.0% after 1 year and 2 years treatment. There are four types of mutation: rt @entity29900 / @entity29901 , rt @entity29900 / @entity32987 , rt @entity32987 , rt @entity29900 . rt @entity29901 mutation in C gene was always accompanied by rt @entity29900 mutation (100%). The rate of rt @entity29900 / @entity29901 mutation in genotype C group was significantly higher than that in genotype B group (77.8% to 25.0%), the same was true for the rt @entity29900 / @entity32987 mutation (22.2% to 12.5%). There was no point mutation in genotype C group. The point mutation of rt @entity32987 and rt @entity29900 appeared only in genotype B group. Gender, nation, family history of @entity1956 and HBeAg were not associated with YMDD mutation (P more than 0.05), while the mutation rate was associated with the disease course and severity of disease. YMDD mutation did not occur in @entity1 with low @entity97 DNA level (less than 10(5) copies/ml). CONCLUSION: YMDD mutation after @entity16332 therapy is associated with @entity97 genotype and P gene mutation type, and prolonged treatment increases the the mutation rate. In order to reduce the incidence of YMDD mutation, @entity1 with @entity66 , lower @entity97 DNA level, more serious @entity409 should be treated with @entity16332 .

title: [Identification of factors associated with YMDD mutation in @entity1 with @entity6194 receiving XXXX treatment].

entities_list: @entity16332 :: ('MESH:D019259', 'Chemical') :: ['lamivudine']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['shorter disease course']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage']

entities_list: @entity6194 :: ('MESH:D019694', 'Disease') :: ['chronic hepatitis B']

answer: @entity16332 :: (MESH:D019259,Chemical) :: ['lamivudine']


abstract: We experienced two cases of @entity362 arising from the chest wall. The first case was a 55-year-old male, and another case was a 70-year-old female. In the second case, the computed tomography was highly suggestive of a @entity5 with almost same density as the subcutaneous adipose tissue. This findings may be diagnostic in assessing intrathoracic @entity362 . Both cases had thoracotomy to remove the @entity5 . The @entity5 were easily resectable, though their capsules were partially unclear. We resected the @entity5 completely together with pleura, periosteum and intercostal muscle. The diagnosis of @entity362 was confirmed postoperatively by histopathologic examination in each case. When the capsule of @entity362 is not clear, combined resection of the @entity5 and chest wall should be considered. There have been no recurrence of the @entity5 in our cases.

title: [Two surgical cases of XXXX ].

entities_list: @entity362 :: ('MESH:D008067', 'Disease') :: ['intrathoracic lipoma', 'lipoma', 'chest wall type lipoma', 'intramuscular lipoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'pleural tumor', 'tumors']

answer: @entity362 :: (MESH:D008067,Disease) :: ['intrathoracic lipoma']


abstract: BACKGROUND: Nephrotoxicity is a major complication with immunosuppression regimens used in transplantation. Calcineurin inhibitor-sparing or reduction regimens using @entity3446 (SRL) have shown variable success in kidney transplantation. There is limited data on the role of SRL on native kidney function in pancreas transplantation. METHODS: All @entity1 undergoing pancreas transplantation from 2003 to 2010 were enrolled in this study (n=65). @entity1 demographic characteristics were identified and divided into two groups: those receiving @entity1140 ( @entity11636 ) in combination with @entity618 ( @entity2098 ) and those maintained on a regimen of Tac and SRL with or without @entity2098 . The slopes for estimated glomerular filtration rate (eGFR), serum @entity1011 level (sCr), and @entity644 changes over time were assessed between groups. Urine protein and @entity1011 ratio (uPr/uCr) was used to assess @entity644 . RESULTS: There was no difference in baseline demographic characteristics. @entity1 were followed for a median of 3 years. Baseline sCr and eGFR were similar between groups. Differences in uPr/uCr and rate of change in sCr and eGFR were not significant between the groups overall or for any specific time. There was worsening of sCr, eGFR, and uPr/uCr within the groups over the period of study. There were no significant differences when groups were split by age or gender or when the SRL group was split further based on @entity2098 inclusion. CONCLUSIONS: Our study findings suggest that using a Tac-SRL regimen in @entity1 with pancreas alone transplantation is a safe approach and may not lead to worsening @entity644 and kidney function when compared with regimens using Tac with @entity2098 .

title: Impact of @entity1140 - @entity3446 maintenance immunosuppression on XXXX and kidney function in pancreas transplant alone recipients.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity644 :: (MESH:D011507,Disease) :: ['proteinuria']


abstract: Resurfacing arthroplasty has become an attractive option for young @entity1 who want to maintain a high activity level. One recent study reported modestly increased activity levels for @entity1 with resurfacing compared to standard @entity572 ( @entity572 ). We conducted a prospective randomized clinical trial to compare clinical outcomes of resurfacing versus large-head metal-on-metal @entity572 . We randomized 107 @entity1 deemed eligible for resurfacing arthroplasty to have either resurfacing or standard @entity572 . @entity1 were assessed for quality-of-life outcomes using the PAT-5D index, WOMAC, SF-36, and UCLA activity score. The minimum followup was 0.8 years (mean, 1.1 years; range, 0.8-2.2 years). Of the 73 @entity1 followed at least one year, both groups reported improvement in quality of life on all outcome measures. There was no difference in quality of life between the two arms in the study. Serum levels of @entity1953 and @entity3407 were measured in a subset of 30 @entity1 . In both groups @entity1953 and @entity3407 was elevated compared to baseline. @entity1 receiving a large-head metal-on-metal total hip had elevated ion levels compared to the resurfacing arm of the study. At 1 year, the median serum @entity1953 increased 46-fold from baseline in @entity1 in the large-head total hip group, while the median serum @entity3407 increased 10-fold. At 1 year, serum @entity1953 was 10-fold higher and serum @entity3407 2.6-fold higher than in the resurfacing arm. Due to these excessively high metal ion levels, the authors recommend against further use of this particular large-head @entity572 . LEVEL OF EVIDENCE: Level I, randomized clinical trial. See Guidelines for Authors for a complete description of levels of evidence.

title: The John Charnley Award: Metal-on-metal hip resurfacing versus large-diameter head metal-on-metal XXXX : a randomized clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3407 :: ('MESH:D002857', 'Chemical') :: ['chromium']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

answer: @entity572 :: (MESH:D006617,Disease) :: ['total hip arthroplasty']