abstract: BACKGROUND: @entity5426 is @entity146 with a high propensity for local recurrence. Electrochemotherapy is an emerging skin-directed therapy, exerting prominent cytotoxic activity, and antivascular effects. Its efficacy in @entity5426 has not been investigated. METHODS: This multicenter retrospective analysis reviewed @entity1 who underwent electrochemotherapy from 2007 to 2014 for superficial @entity5426 . @entity1732 was administered intravenously and delivered within @entity5 by means of percutaneously applied electric pulses, according to the European Standard Operating Procedures for Electrochemotherapy. @entity5 assessment was performed using RECIST (version 1.1). @entity137 (CTCAE, v4.0) and local progression-free survival (LPFS) were also evaluated. RESULTS: Nineteen @entity1 (13 with locally advanced and 6 with @entity5426 ) were treated. @entity5 sites were: scalp (n   =   5), breast (n   =   8), other skin sites (n   =   3), and soft tissue (n   =   3). Target lesions (n   =   54) ranged in size from 1.5 to 2.5   cm (median, 2   cm). Treatment was well tolerated. After 2 months, an objective response was observed in 12/19 (63%) @entity1 , complete in 8 (42%). One-year LPFS within treatment field was 68%. Local symptom improvement included palliation of @entity548 (5/19 @entity1 ) and @entity158 relief (6/19 @entity1 ). CONCLUSIONS: Electrochemotherapy may represent a new locoregional treatment for selected @entity1 with superficial @entity5426 . J. Surg. Oncol. 2016;114:246-253.    2016 Wiley Periodicals, Inc.

title: Local treatment with electrochemotherapy of superficial XXXX : Efficacy and safety results from a multi-institutional retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['an aggressive vascular neoplasm']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor', 'tumors']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcoma', 'angiosarcomas', 'Angiosarcoma', 'metastatic angiosarcomas', 'advanced angiosarcomas']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['Bleomycin']

answer: @entity5426 :: (MESH:D006394,Disease) :: ['angiosarcomas']


abstract: OBJECTIVE: The objective of this study was to develop a valid and reliable health-related quality of life (HRQOL) questionnaire for use in multinational clinical trials of @entity1 with type I and @entity2175 . METHODS: Through @entity1 focus groups and expert clinician panels in the United States (US) and France, relevant HRQOL domains for @entity1 with type I and @entity2175 were identified. A draft questionnaire was developed by including validated, widely used generic and @entity6 -specific domains and by developing original questions as required. A pilot study (n = 123) was conducted to evaluate the psychometric properties of the draft questionnaire with revisions being subsequently made. Data collected from two multinational clinical trials of @entity1 with type I and @entity2175 were used to further validate and enhance the questionnaire (DQLCTQ). RESULTS: A total of 942 @entity1 were recruited in the clinical trials from Canada, France, Germany, and the United States. The mean age was 33.8 years for @entity1 with @entity1723 (n = 468) and 58.2 years for @entity1 with @entity2175 (n = 474). The mean HbAlc level at baseline was 8.6. The revised version of the questionnaire (DQLCTQ-R) contains a total of 57 questions comprising 8 generic and disease-specific domains, as follows: Physical Function; Energy/Fatigue; Health Distress; Mental Health; Satisfaction; Treatment Satisfaction; Treatment Flexibility; and Frequency of Symptoms. Intraclass correlation coefficients range from 0.74 to 0.90 and Cronbach's alphas range from 0.77 to 0.90. With very few exceptions, all eight domains were able to discriminate between type I and @entity2175 , tight and poor metabolic control, male and female, and good and poor self perceived control of @entity6 . Four domains (Treatment Satisfaction, Health/Distress, Mental Health, and Satisfaction) were responsive to clinical change in metabolic control. CONCLUSION: The DQLCTQ-R is a reliable, valid, and comprehensive HRQOL instrument. It is suitable in multinational clinical trials to evaluate new or alternative treatments for @entity1 with type I and @entity2175 .

title: Development and validation of the XXXX Quality of Life Clinical Trial Questionnaire.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['type I diabetes']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['type II diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: Our previous experiments demonstrated that systemic treatment with GM1 @entity4163 @entity146 and spinal cord metabolic activity in a @entity35 model of @entity158 produced by experimental sciatic nerve ligation (chronic constrictive injury, CCI). In the present study, we examined the effects of intrathecal (i.t.) GM1 treatment on thermal @entity1931 and spontaneous @entity158 resulting from nerve ligation in order to determine the locus of GM1 action. In addition, a local anesthetic agent, @entity1341 , given alone or combined with i.t. GM1, was applied to the injured sciatic nerve to determine if peripheral nerve anesthesia would influence post- @entity146 . Thermal @entity1931 to radiant heat decreased in a dose-dependent manner when GM1 (10-80 nmol, i.t.) was administered once daily onto the lumbar segments of the spinal cord beginning 1 h after @entity128 and continued for the first 9 days after nerve ligation. Moreover, this GM1 (80 nmol) treatment regimen reliably lowered spontaneous @entity158 behavior rating scores in CCI @entity35 suggesting the possible attenuation of spontaneous @entity158 . The central site of i.t. GM1 action is located at the caudal (probably lumbar) spinal cord, since i.t. injection of 20 nmol GM1 onto the cervical spinal cord did not produce any protective effect. A single perinerve injection of a local anesthetic agent, @entity1341 (0.5%, 0.6 ml), on the 3rd day after nerve ligation reduced thermal @entity1931 for at least 24 h following injection, a duration longer than that of the local anesthetic action of @entity1341 . Neither a single @entity1341 injection nor four daily i.t.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Intrathecal GM1 @entity4163 and local nerve anesthesia reduce XXXX in @entity35 with experimental peripheral mononeuropathy.

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['injury nociceptive behaviors', 'reduces nociceptive behaviors']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['experimental nerve injury']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful peripheral mononeuropathy', 'pain behaviors', 'pain']

entities_list: @entity4163 :: ('CHEBI:28892', 'Chemical') :: ['ganglioside']

answer: @entity146 :: (MESH:D001523,Disease) :: ['nociceptive behaviors']


abstract: OBJECTIVE: @entity1 with @entity71 ( @entity71 ) have delayed cortical maturation, evidenced by regionally specific slower cortical thinning. However, the relationship between cortical maturation and attention capacities in typically developing @entity1 is unknown. This study examines cortical @entity121 correlates of inattention symptoms in a large sample of healthy @entity1 . METHOD: Data from 357 healthy subjects (6.0-18.4 years of age) were obtained from the NIH MRI Study of Normal Brain Development. In cross-sectional analysis (first visit, n = 257), @entity1 Behavior Checklist Attention Problems (AP) scores were linearly regressed against cortical @entity121 , controlling for age, gender, total brain volume, and site. For longitudinal data (up to three visits, n = 357/672 scans), similar analyses were performed using mixed-effects linear regressions. Interactions of AP with age and gender were tested. RESULTS: A cross-sectional "AP by age" interaction was found in bilateral orbito-frontal cortex, @entity75 , bilateral ventromedial prefrontal cortex, bilateral dorsolateral prefrontal cortex, and several additional attention network regions. The interaction was due to negative associations between AP and @entity121 in younger subjects (6-10 years of age) that gradually disappeared over time secondary to slower cortical thinning. Similar trends were present in longitudinal analyses. CONCLUSIONS: Higher AP scores were associated with thinner cortex at baseline and slower cortical thinning with aging in multiple areas involved in attention processes. Similar patterns have been identified in @entity71 , suggesting a dimensional component to the link between attention and cortical maturation. The identified association between cortical maturation and attention in healthy development will help to inform studies of neuroimaging biomarkers of @entity71 .

title: Decreased regional cortical XXXX and thinning rate are associated with inattention symptoms in healthy @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children', 'Children']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention-deficit/hyperactivity disorder']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['right inferior frontal cortex']

answer: @entity121 :: (MESH:D009135,Disease) :: ['thickness']


abstract: The @entity28011 ( @entity28011 ) is one of the two major clinico-radiological subtypes of the @entity28011 ( @entity28011 ). The @entity28011 is a rare heterogeneous entity characterized by @entity154 , short-neck, short-trunk, normal sizes limbs, with multiple @entity3574 at all levels of the vertebral column and @entity154 . The @entity28011 has been classified into 2 major clinical phenotypes, based on the extent and distribution of @entity154 , the pattern of inheritance and the prognosis. We report the case of a non-consanguineous 35-year-old female @entity1 , with a history of multiple large @entity2909 gravida 1, para 1. A three-dimensional ultrasound at 18 weeks of gestation revealed: thoracic and lumbar hemivertebrae with abnormal alignment of the vertebral bodies and kypho-scoliosis, also the absence of two right ribs and abnormal shaped ribs. The biometric measurement was appropriate for gestational age and no other @entity600 were found. Although there was no previous history, based on the three-dimensional ultrasound findings a mild subtype of @entity28011 was suspected. At term, the @entity1 gave birth, by Cesarean section, to a male fetus, with a weight of 2700g, a length of 50cm and a calculated Apgar score of 9. The postpartum examination of the fetus confirmed the diagnose of @entity28011 . The evolution of the newborn was good - he had no respiratory difficulty; he will benefit from an experimental surgery involving expandable @entity702 ribs. Our case illustrates the importance of an accurate ultrasound examination, which can be hindered by multiple large leyomiomas, in order to diagnose and to differentiate the two subtypes of @entity28011 . The @entity28011 can have a favorable evolution with the appropriate perinatal and postpartum care.

title: A rare case of fetal spondylocostal dysostosis - prenatal diagnosis and perinatal care in a XXXX with multiple large @entity2909 .

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['skeletal anomalies', 'costal defects', 'facial dysmorphism']

entities_list: @entity3574 :: ('OMIM:277300', 'Disease') :: ['vertebral anomalies']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations']

entities_list: @entity28011 :: ('MESH:C537565', 'Disease') :: ['spondylocostal dysostosis', 'SCD', 'JLS', 'Jarcho-Levin syndrome']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity2909 :: ('MESH:D007889', 'Disease') :: ['leiomyomas']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: The aim of this study was to investigate the oxygenation of the gastrointestinal tract mucosa using indirect pH measurements in a porcine septic model (intravenous infusion of live @entity526 ). By means of intraluminally placed balloon catheters (Tonomitior) permeable to @entity515 , intramucosal pH (pHi) was calculated using the Henderson-Hasselbalch equation. Cardiopulmonary hemodynamics and portal blood flow were measured using Swan-Ganz catheters. Samples were taken from the gastrointestinal tract for histological examination. Nine @entity1707 were given i.v. @entity526 infusion while six @entity1707 served as sham controls and were given an equivalent amount of Ringer's solution only. All septic animals developed hemodynamic signs of @entity326 . Gastric, small intestinal and sigmoid colonic pHi decreased gradually during the four hour observation period. In the small intestine and the sigmoid colon the decrease was significant already after one hour (p less than 0.01 and p less than 0.02, respectively). Microscopic examination of tissue specimens obtained 4 hours following induction of @entity295 revealed normal or close to normal findings in all the sham and in more than half of the septic animals. These findings indicate that abnormally low gastrointestinal intramucosal pH may be found early in @entity295 , preceding microscopically detectable damage by several hours. It is concluded that the tonometer technique does provide early detection of @entity344 in @entity326 .

title: Early detection of @entity344 in porcine @entity526 XXXX .

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'septicemia']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal ischemia']

answer: @entity295 :: (MESH:D018805,Disease) :: ['sepsis']


abstract: OBJECT: In this paper, the authors' goal was to study the influence of the @entity2204 allele on the clinical outcome in @entity1 treated for severe @entity131 ( @entity131 ) with an @entity428 ( @entity428 )-targeted therapy based on the Lund concept. METHODS: The authors conducted a prospective double-blinded randomized trial in which they examined @entity1 with severe @entity131 . Inclusion criteria consisted of a Glasgow @entity772 Scale (GCS) score < or = 8 at the time of intubation and sedation, @entity1 age between 15 and 70 years, an initial cerebral perfusion pressure > 10 mm Hg, and arrival to the hospital < 24 hours after @entity130 . Blood samples for the analysis of @entity2204 allele types were collected. Independent staff members evaluated outcomes by obtaining Glasgow Outcome Scale (GOS) scores at 3, 12, and 24 months. RESULTS: The occurrence of the epsilon4 allele was analyzed in 46 @entity1 (mean age 35 +/- 2.2 years with a median GCS score of 6 [range 3-8]). The epsilon4 allele was present in 39.1% of the @entity1 . The @entity428 , cerebral perfusion pressure, and injury severity score were not statistically significantly different between the groups. The median GOS score at 3 months was 3.5, and at 12 and 24 months was 4 (range 1-5). Except for the GOS score at 3 months, which was dichotomized as favorable (GOS Score 4 or 5) and unfavorable (GOS Scores 1-3), no statistically significant differences in outcome, irrespective of GOS dichotomization used, were found between the @entity1 with the epsilon4 allele and those without. The presence of the epsilon4 allele did not predict for clinical outcome, but GCS and @entity428 did. CONCLUSIONS: The presence of epsilon4 is not associated with long-term clinical outcome in @entity1 with severe @entity131 treated with an @entity428 targeted therapy, based on the Lund concept.

title: The @entity2204 allele and outcome in severe XXXX treated by an @entity428 -targeted therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP', 'intracranial pressure']

entities_list: @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E epsilon4', 'apolipoprotein E']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: BACKGROUND: @entity4929 ( @entity4929 ) of the @entity788 is often found with distinct @entity1124 ( @entity1124 ) in the same @entity788 . The aim of this study was to clarify whether endoscopic retrograde pancreatography (ERP) would be useful for the early detection of concomitant PDACs in @entity1 with IPMNs. METHODS: Medical records of 179 @entity1 who were histologically confirmed to have IPMNs after resection between 1987 and 2011 were reviewed. The @entity1 having concomitant PDACs were selected, and the diagnostic abilities to detect concomitant PDACs of computed tomography (CT), magnetic resonance imaging (MRI), endoscopic ultrasonography (EUS), and ERP were compared between early (stages 0-I according to Japanese General Rules for @entity788 ) and advanced (stages II-IV) PDACs. RESULTS: A total of 23 PDACs developed synchronously or metachronously in 20 @entity1 , and the prevalence of PDACs concomitant with IPMNs was 11.2 % (20/179). Sensitivities of CT (16 vs. 87 %), MRI (29 vs. 93 %), and EUS (29 vs. 92 %) in the early group were significantly lower than those in the advanced group (p < 0.01). On the other hand, the sensitivity of ERP in the early group was as high as that in the advanced group (86 vs. 82 %, respectively, p > 0.99). Among 7 early PDACs, 3 were diagnosed only by ERP. CONCLUSIONS: ERP has an important role in the early diagnosis of distinct PDACs in @entity1 with IPMNs. Further investigation is necessary to clarify the indication and the timing of ERP during management of IPMNs in term of early detection of concomitant PDACs.

title: Role of endoscopic retrograde pancreatography for early detection of @entity1124 concomitant with XXXX of the @entity788 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreas', 'Pancreatic Cancer']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['Intraductal papillary mucinous neoplasm', 'IPMN']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['PDAC', 'pancreatic ductal adenocarcinoma']

answer: @entity4929 :: (MESH:C565310,Disease) :: ['intraductal papillary mucinous neoplasm']


abstract: @entity385 in the vertebrobasilar arterial territory often presents stunning signs and symptoms, and poses little difficulty in the clinical diagnosis. But in less dramatic cases, it is often difficult to make accurate clinical diagnosis and to document the precise extent of an @entity1188 . The purpose of the present study is to demonstrate clinicotopographic correlations in @entity1 with various brainstem and @entity1188 and to reevaluate the importance of bedside clinical examinations for understanding pathophysiology and planning management of the @entity1 . One hundred forty-three @entity1 with clinical diagnosis of the vertebrobasilar @entity1188 confirmed by MRI were studied. MRI is superior to CT scanning in delineating areas of @entity1188 in the territory of posterior cerebral circulation because of the three dimensional approach and the lack of bone artifact. MRI also allowed very precise clinicotopographic correlations even in @entity1 with good recovery, in whom pathologic verification of the lesion is not possible. There are some restrictions of MRI diagnosis to detect the clinical features which change from hour to hour, because of the mechanical limitation in spatial resolution and of the temporal uncertainty of the lesions such as reversible @entity4 or coincidental asymptomatic old lesions. Clinical importance of ocular signs (eg. skew deviation, gaze limitations, nystagmus, @entity2300 and so on) was discussed. Some @entity2358 (eg. gaze paresis, @entity751 , 'one-and-a-half' syndrome, @entity346 at the primary position) served as useful localizing signs, and especially their consecutive observations were of importance for clinical local diagnosis. Clinical syndromes, caused by lacunar lesions located either in the supratentorial or in the infratentorial structures, such as @entity1269 and @entity1269 were also discussed. In some cases of these syndromes, MRI failed to document the precise lesion responsible for the episode due to the multiplicities of small asymptomatic lesions. Even in such cases, detailed clinical informations (temporal profiles of the episode, past medical histories, neuro-ophthalmic signs and so on) may enable the differential diagnosis. It is concluded that the use of new imaging techniques such as MRI may provide new insights in the diagnosis of @entity66 , but the importance of clinical observations can not be overemphasized.

title: [Clinical aspects of XXXX ].

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular diseases']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['ataxic hemiparesis', 'pure motor hemiparesis']

entities_list: @entity2358 :: ('MESH:D020820', 'Disease') :: ['eye-movement abnormalities']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['cerebellar infarctions', 'infarct', 'infarction']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['MLF syndrome']

entities_list: @entity2300 :: ('MESH:D011681', 'Disease') :: ['pupillary abnormalities']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['lateropulsion or contrapulsion of eyes, and vertical nystagmus']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['Ischemic stroke']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['brainstem infarction']


abstract: PURPOSE: Operative repair for complicated pouch and @entity9292 is often difficult. We present our experience with ten consecutive @entity1 operated on for complicated pouch and @entity9292 by transposition of the rectus abdominis muscle. METHODS: Ten @entity1 with high and complex pouch and @entity9292 were treated with the interposition of a vascularized rectus abdominis muscle flap. All @entity1 received standard bowel preparation and antibiotics. All were diverted by a temporary ileostomy. RESULTS: Causes of @entity292 included @entity30 (n = 3), previous rectal surgery (n = 5), anal @entity1146 (n = 1), and sphincter repair (n = 1). Three @entity1 had a third recurrence. The procedure was performed in combination with a plastic surgeon. All @entity292 healed. No special postoperative care was required. There were no cosmetic or functional complaints caused by transposition of the rectus abdominis muscle. CONCLUSIONS: Transposition of the rectus abdominis muscle is a suitable technique in treatment of @entity292 between the rectum or ileal pouch and the vagina or urinary system, with no obvious side effects and excellent clinical outcome.

title: Transposition of the rectus abdominis muscle for complicated pouch and XXXX .

entities_list: @entity9292 :: ('MESH:D012003', 'Disease') :: ['rectal fistulas']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['fistulas']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

answer: @entity9292 :: (MESH:D012003,Disease) :: ['rectal fistulas']


abstract: Objectives. To evaluate the efficacy and safety of personalized peptide vaccination ( @entity2286 ) combined with chemotherapy for @entity1 with previously treated advanced @entity1149 ( @entity1149 ). @entity1 and Methods. Previously treated PS0-1 @entity1 with IIIB/IV @entity470 ( @entity470 ) wild genotype @entity1149 were randomly assigned to @entity1205 (60   mg/m(2) on Day 1) plus @entity2286 based on preexisting host immunity or @entity1205 plus placebo. @entity1205 administration was repeated every 3 weeks until disease progression. Personalized peptides or placebo was injected subcutaneously weekly in the first 8 weeks and biweekly in subsequent 16 weeks. The primary efficacy endpoint was progression-free survival (PFS). Results. @entity2286 related @entity137 was grade 2 or less skin reaction. The median PFS for placebo arm and @entity2286 arm was 52 days and 59 days, respectively. There was no significant difference between two arms by log-rank test (p = 0.42). Interestingly, PFS and overall survival (OS) in humoral immunological responder were significantly longer than those in nonresponder. Conclusion. @entity2286 did not improve the survival in combination with @entity1205 for previously treated advanced @entity1149 . However, @entity2286 may be efficacious for the humoral immunological responders and a further clinical investigation is needed.

title: Randomized Phase II Study of @entity1205 plus Personalized Peptide Vaccination versus @entity1205 plus Placebo for XXXX with Previously Treated Advanced Wild Type @entity470 Non-Small-Cell Lung Cancer.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel', 'Docetaxel']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: To compare an accelerated intervention incorporating early therapeutic exercise after acute @entity3681 with a standard protection, rest, ice, compression, and elevation intervention. DESIGN: Randomised controlled trial with blinded outcome assessor. SETTING: Accident and emergency department and university based @entity2587 clinic. @entity1 : 101 @entity1 with an acute grade 1 or 2 @entity3681 . INTERVENTIONS: @entity1 were randomised to an accelerated intervention with early therapeutic exercise (exercise group) or a standard protection, rest, ice, compression, and elevation intervention (standard group). MAIN OUTCOME MEASURES: The primary outcome was subjective ankle function (lower extremity functional scale). Secondary outcomes were @entity158 at rest and on activity, @entity4 , and physical activity at baseline and at one, two, three, and four weeks after injury. Ankle function and rate of reinjury were assessed at 16 weeks. RESULTS: An overall treatment effect was in favour of the exercise group (P=0.0077); this was significant at both week 1 (baseline adjusted difference in treatment 5.28, 98.75% confidence interval 0.31 to 10.26; P=0.008) and week 2 (4.92, 0.27 to 9.57; P=0.0083). Activity level was significantly higher in the exercise group as measured by time spent walking (1.2 hours, 95% confidence interval 0.9 to 1.4 v 1.6, 1.3 to 1.9), step count (5621 steps, 95% confidence interval 4399 to 6843 v 7886, 6357 to 9416), and time spent in light intensity activity (53 minutes, 95% confidence interval 44 to 60 v 76, 58 to 95). The groups did not differ at any other time point for @entity158 at rest, @entity158 on activity, or @entity4 . The reinjury rate was 4% (two in each group). CONCLUSION: An accelerated exercise protocol during the first week after @entity3681 improved ankle function; the group receiving this intervention was more active during that week than the group receiving standard care. TRIAL REGISTRATION: Current Controlled Trials ISRCTN13903946.

title: Effect of accelerated rehabilitation on function after XXXX : randomised controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants', 'PARTICIPANTS']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['ankle sprain', 'ankle sprains']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity2587 :: ('MESH:D001265', 'Disease') :: ['sports injury']

answer: @entity3681 :: (MESH:D016512,Disease) :: ['ankle sprain']


abstract: Surface-negative DC shifts, arising from depolarization of apical dendrites of cortical pyramidal cells, represent excitability of cortical neuronal networks. Hyperventilation, used in @entity302 diagnosis to provoke @entity302 , is thought to increase excitability of neuronal tissue; correspondingly, hyperventilation produces negative DC shifts. Extreme negative DC shifts, accompanying @entity302 patterns, have been observed in @entity302 @entity1 during hyperventilation. Anticonvulsants, supposed to dampen cortical excitability, should inhibit the development of overexcitability and, hence, also of pronounced negative DC shifts. The present study examined DC shifts induced by hyperventilation in healthy @entity1 subjects under the influence of the @entity1245 , @entity2053 , which is used as anticonvulsant. In a double-blind setting, 36 male student volunteers received 4.5 mg @entity2053 or the equivalent amount of placebo. DC-EEG and respiration rate were measured during 3 periods each of 3 min: baseline, hyperventilation, and recovery. Compared to baseline, hyperventilation produced a negative DC shift of an average 36 +/- 8 microV under placebo conditions. @entity2053 reduced the hyperventilation-induced negativity to 13 +/- 5 microV. Negativity suppression became weakened with increasing blood plasma levels of the drug. Respiration depth and frequency, increasing under hyperventilation, did not differ among the groups. @entity2053 treatment gave rise to beta-waves and prevented the increase in alpha and theta activity that was found in placebo subjects during the recording period; this was only true, however, for low to moderate plasma concentrations of @entity2053 . Results are consistent with the notion that a hyperventilation-induced increase in neuronal excitability can be measured by cortical DC shifts. The reduction of negative shifts under anticonvulsants might indicate dampening of @entity528 which is intended by antiepileptic drugs.

title: Hyperventilation-induced EEG changes in XXXX and their modulation by an anticonvulsant drug.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy', 'epileptiform EEG', 'epileptiform discharges']

entities_list: @entity2053 :: ('MESH:D002998', 'Chemical') :: ['Clonazepam', 'clonazepam']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['cortical neuronal excitability']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: @entity2791 may be due to @entity66 or @entity8 ( @entity4267 ). Management of both diseases requires treatment of @entity101 usually observed in such @entity1 ; however, clinical presentation, mechanism and treatment of these 2 diseases are usually different. Renal @entity4267 is now considered as a @entity262 , the cause of which may be genetic (although the exact cause is still elusive). Renal arteries are the most frequent localizations of @entity4267 , but extra renal arteries may also be involved (usually carotid arteries). Risk factors of @entity101 -induced renal @entity4267 include @entity172 treatment and smoking. Renal @entity4267 are mostly found in young @entity1 and in @entity1 who present with recent severe and/or refractory symptomatic @entity101 . Diagnosis is usually easy (Doppler, CT-scan), and treatment of renal @entity4267 is angioplasty in most cases. @entity2791 is usually found in @entity1 with other @entity66 ( @entity3657 , carotid, @entity453 ...). Clinical presentation include severe or refractory @entity101 , recurrent @entity3126 in a @entity1 with @entity101 , progressive @entity8 spontaneously or after medical treatment with converting-enzyme inhibition or @entity2178 blockade, @entity101 in a @entity1 (usually smoker or ex-smoker) with diffuse @entity455 . Management of @entity8 is medical treatment in all @entity1 (aggressive treatment of cardiovascular risk factors, control of arterial pressure); revascularization is required in some @entity1 only since it rarely cures @entity101 : the goal of revascularization is mostly renal function protection, which may be observed in selected @entity1 . Revascularization must be decided by physicians or teams involved in the care of such @entity1 . @entity1 with @entity8 are at very high renal and cardiovascular risk : aggressive management of cardiovascular risk factors is crucial.

title: [ @entity2791 : @entity66 and XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'Patients', 'patients', 'patient']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibromuscular dysplasia', 'atheromatous renal artery disease', 'renal dysfunction']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['atheromatous vascular disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['atheromatous disease']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['flash pulmonary edema']

entities_list: @entity2178 :: ('183', 'Gene') :: ['angiotensin II']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['Renal artery stenosis', 'Atheromatous renal artery stenosis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity4267 :: (MESH:D005352,Disease) :: ['fibromuscular dysplasia']


abstract: There is little information in the English-language literature about the epidemiology of @entity14253 in the eastern Chinese population. A large retrospective study (6982 primary @entity5 during 23 years) was carried out to investigate the clinicopathological features ( @entity5 location, @entity1 sex and age) of these @entity5 in this population. 3593 @entity5 were in males and 3389 in females. @entity5123 (69%) was the most common @entity5 and 20% were located in minor glands. 92% of @entity4724 occurred in males. @entity5 were predominantly @entity2347 (30%) and @entity3975 (30%). Incidences of @entity189 (5%) and polymorphous low-grade @entity420 (1%) of @entity5 were identified. 28% of @entity5 originated from minor glands. Most findings were similar to those in the literature, with some variations. The @entity5 slightly predominated in males. Relatively higher incidences of @entity5 and specifically of @entity5123 in minor glands were noted. @entity2347 and @entity3975 constituted the most common @entity5 . There was a high incidence of @entity189 but a low incidence of polymorphous low-grade @entity420 . The historical significant male predominance of @entity4724 was confirmed.

title: XXXX in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population.

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['Pleomorphic adenoma', 'pleomorphic adenoma']

entities_list: @entity3975 :: ('MESH:D018277', 'Disease') :: ['mucoepidermoid carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies', 'malignant tumors', 'minor gland tumors', 'Malignant tumors', 'salivary tumors', 'tumors']

entities_list: @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma', 'Adenoid cystic carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['lymphoepithelial carcinomas']

entities_list: @entity14253 :: ('MESH:D012468', 'Disease') :: ['salivary gland neoplasms']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity4724 :: ('MESH:D000235', 'Disease') :: ["Warthin's tumors", "Warthin's tumor"]

answer: @entity14253 :: (MESH:D012468,Disease) :: ['Salivary gland neoplasms']


abstract: OBJECTIVE: The purpose of this paper is toexplore the clinical features, treatment and prognosis of @entity44 . METHODS: The clinical data, serum levels of @entity5 markers, treatment regimens and prognosis of 15 @entity1 with @entity44 were reviewed retrospectively. RESULTS: In @entity1 whose plasma alpha-fetoprotein (AFP) and beta- @entity1 chorionic gonadotropin (beta-HCG) were determined, AFP and beta-HCG were elevated in 57.1 and 16.7% of the cases, respectively. All @entity1 received surgical treatment. The @entity5 was totally removed in 12 cases, subtotally in 2, and partially in 1 case. After surgery, of the 15 @entity1 , 9 received radiotherapy, 4 gamma knife surgery and 7 chemotherapy. Thirteen @entity1 were followed up. Compared to the common 5-year survival rate of 40%, in @entity1 who received gamma knife surgery, the 5-year survival rate after surgery was 100%, which is better than the 5-year survival rate of @entity1 who did not receive gamma knife surgery (p = 0.0049). Postoperative radiotherapy and chemical therapy had no significant impact on the 5-year survival rate (p > 0.05). CONCLUSIONS: The prognosis of @entity44 is poor. The detection of their clinical manifestation, the analysis of imaging features and the serum levels of @entity5 markers are helpful in diagnosing intracranial @entity44 . The total removal of the @entity5 is important to cure the disease. We did not see a difference in outcome between @entity1 who received postoperative chemotherapy or radiotherapy and those who did not. Regular follow-up MRI examinations are necessary so that the conditions of the @entity1 can be closely monitored. If a @entity1 has residual or recurrent @entity5 after surgery, gamma knife surgery can be effective.

title: Diagnosis and treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratomas', 'intracranial immature teratomas']

answer: @entity44 :: (MESH:D013724,Disease) :: ['intracranial immature teratoma']


abstract: OBJECTIVE: To retrospectively analysis the clinical data of @entity2103 repair with greater auricular nerve graft. METHOD: The transmastoid approach was adopted to repair the @entity2103 by means of nerve grafting. @entity86 were graded according to the House-Brackmann scale. RESULT: The patterns of @entity174 in the 8 @entity1 were longitudinal, most lesions occurred in the region of the second genu and its surrounding, preoperatively, all @entity1 had Grade VI function. In 3 @entity1 of @entity5 , the @entity5 involved multiple nerve segments, and histologic results were all @entity808 , preoperatively, 1 case had Grade III function, 2 cases had Grade V function. In 2 @entity1 of @entity2103 was @entity102 media with @entity3540 , the lesions were localized at the mastoid segment and the second genu respectively. In 1 @entity1 of molten steel burn, the lesions was localized at the tympanic segment, preoperative @entity2103 was Grade VI. In addition to 3 cases lost to follow-up, the remaining @entity1 , 4 recovered to a Grade III, 3 to a Grade VI, 2 to a Grade V and 2 remained at Grade VI. CONCLUSION: In present study, the most common cause of facial nerve transection was @entity174 . Facial nerve reconstruction by means of greater auricular nerve grafting was a practical and effective method, the best postoperative recovery of @entity2103 was Grade III.

title: [Greater auricular nerve graft for repair of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity808 :: ('MESH:D009442', 'Disease') :: ['schwannomas']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['temporal bone fracture']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['facial nerve tumors', 'tumors']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['facial nerve defects', 'iatrogenic trauma of the facial nerve, the primary disease', 'facial nerve function']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic otitis']

entities_list: @entity3540 :: ('MESH:D002781', 'Disease') :: ['cholesteatoma']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['Preoperative and postoperative facial nerve functions']

answer: @entity2103 :: (MESH:D005155,Disease) :: ['facial nerve defects']


abstract: BACKGROUND: Second-line treatment of advanced @entity1149 ( @entity1149 ) improves overall survival. There is a lack of data regarding the impact on @entity1 ' overall health condition. This prospective, non-interventional study evaluated performance status (PS) and health-related quality of life (HR-QoL) during second-line pemetrexed treatment in routine clinical practice. METHODS: Stage III/IV @entity1149 @entity1 who initiated second-line pemetrexed (standard vitamin and @entity619 supplementation) were observed for a maximum of 9 treatment cycles. The primary objective was to evaluate the proportion of @entity1 achieving improvement of Karnofsky Index (KI) of >=  10% (absolute) or maintaining KI >=  80% after the second treatment cycle ("KI benefit response"). HR-QoL was self-rated using the EuroQoL-5D questionnaire (EQ-5D). Factors potentially associated with KI benefit response were evaluated using logistic regression models. RESULTS: Of 521 eligible @entity1 (73.5% Stage IV, median age 66.3 yrs, 36.1% >=  70 yrs, 62.0% with KI >=  80%), 471 (90.4%) completed at least 2 treatment cycles. 58.0% (95%CI 53.6%;62.2%) achieved KI benefit response after the second cycle. @entity1 with baseline KI >=  80%, no Grade 3/4 @entity137 during the first 2 cycles, or combination regimen as prior first-line therapy were more likely to achieve a KI benefit response. EQ-5D scores improved over time. Grade 3/4 @entity137 were reported in 23.8% of @entity1 (mainly fatigue/ @entity1395 15.9%, @entity1398 8.7%). CONCLUSIONS: In this large prospective, non-interventional study of second-line pemetrexed treatment in @entity1 with advanced @entity1149 , including 36% elderly @entity1 ( >=  70 years), physician-rated PS and self-rated HR-QoL were maintained or improved in the majority of @entity1 . TRIAL REGISTRATION: Registered on ClinicalTrials.gov (NCT00540241) on October 4, 2007.

title: Second-line treatment of stage III/IV non-small-cell lung cancer ( XXXX ) with pemetrexed in routine clinical practice: evaluation of performance status and health-related quality of life.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['NSCLC']


abstract: BACKGROUND/AIMS: The incidence of @entity1561 has been increasing parallel to @entity28 in the pediatric age group. This study aimed to analyze the factors that are related to @entity1561 in @entity28 @entity1 . METHODS: 101 @entity28 @entity1 and 68 non- @entity28 controls were included in the study. @entity1560 was investigated by ultrasonography. The subjects were divided into three groups: 53 @entity28 @entity1 with @entity1560 (Group I), 48 @entity28 @entity1 without @entity1560 (Group II), and 68 controls without @entity1560 (Group III). Group I was further divided into those with Grade 1 @entity1560 (44 @entity1 , Group Ia) and higher grades of @entity1560 (9 @entity1 , Group Ib). The relationships of body mass index, serum ALT, lipids, leptin, and insulin resistance index with @entity1560 were analyzed. RESULTS: 52.4% of @entity28 @entity1 had @entity1560 and 13.8% had high ALT levels. Additionally, all @entity1 with elevated ALT levels were seen to have @entity1560 by ultrasonography. Leptin and insulin resistance index levels were higher in @entity28 groups than controls; however, the difference disappeared when these levels were adjusted for body mass index. ALT levels were higher in Group I (31.5+/-30.2) than Group II (18.0+/-7.1) and Group III (14.5+/-5.2) (p<0.05). Group Ib showed higher VLDL and ALT levels than Group Ia (p<0.05). Multiple regression analysis revealed that body mass index was the most important determinant of @entity1560 , while body mass index and VLDL were the determinants of higher ALT levels. CONCLUSIONS: We suggest that body mass index and VLDL are the most important determinants of @entity1561 and elevated ALT levels in @entity28 @entity1 . The contribution of leptin to this process could not be determined in our findings.

title: Factors related to @entity1561 in @entity28 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity1561 :: ('MESH:D065626', 'Disease') :: ['non-alcoholic fatty liver disease']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['liver steatosis', 'Liver steatosis', 'steatosis', 'fatty liver']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: OBJECTIVE: To test the effect of interferon alfa and @entity5371 ( @entity5371 ) in @entity1 with @entity12539 . DESIGN: An open trial of chemotherapy and intensive care in @entity1 with early rabies. SETTING: The intensive care unit of a Bangkok hospital. @entity1 : Four conscious @entity1 with clinical @entity12539 . INTERVENTIONS: Rapid virological diagnosis of rabies. Treatment with intravenous and intraventricular injections of high doses of lymphoblastoid interferon alfa in three @entity1 and @entity5371 in one @entity1 . Intensive care was given throughout. MAIN OUTCOME MEASURES: @entity281 confirmed by antigen detection and virus isolation. Rabies neutralising antibody and specific IgM sought in serum and cerebrospinal fluid. Interferon concentrations monitored before and during treatment in three @entity1 . RESULTS: Interferon alfa treatment produced high concentrations in serum and cerebrospinal fluid. All four @entity1 died after 5 1/2 to 12 1/2 days of treatment with no evidence of virostatic or clinically beneficial effects from either treatment. CONCLUSION: Interferon alfa treatment is not effective in @entity12539 . The use of @entity5371 warrants further study, possibly combined with new therapeutic methods.

title: Failure of interferon alfa and @entity5371 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Rabies infection']

entities_list: @entity12539 :: ('MESH:D011818', 'Disease') :: ['rabies encephalitis']

entities_list: @entity5371 :: ('MESH:D012254', 'Chemical') :: ['ribavirin', 'tribavirin']

answer: @entity12539 :: (MESH:D011818,Disease) :: ['rabies encephalitis']


abstract: OBJECTIVES: This study examined @entity296 and obstruction, and related these to plaque in the epicardial coronary arteries supplying the affected microvessels. BACKGROUND: @entity1186 often causes microemboli and @entity3885 . The consequences of myocardial microvessel obstruction and myocyte @entity39 are substantial, yet histopathologic characterization of @entity453 has been incompletely characterized. This study examined @entity296 , and related these to plaque in the coronary arteries supplying the microvessels. METHODS: Hearts from @entity944 @entity1 underwent examination for @entity453 . RESULTS: Forty-four hearts were available for evaluation. Mean age at death was 51 +/- 15 years. Coronary artery analysis found 26 @entity397 and 21 erosions, and a mean of 4.5 microemboli per heart. @entity3885 occurred most often from eroded plaques. Microemboli and occluded intramyocardial vessels were most common in the left anterior descending coronary artery, and all vessels contained fibrin and platelets. Mean stenoses of the culprit lesion was 74% in those with @entity999 and 75% in those without (p = NS). Intramyocardial microemboli were more common in plaque erosion than in rupture. Microvessels <200 mum were most often those that were occluded. CONCLUSIONS: @entity3885 are common in @entity1 dying of acute @entity1186 . @entity2681 is more likely to cause @entity999 in vessels <200 mum. These @entity999 and microvessel obstruction have a prominent clinical role since myonecrosis is often associated with these findings.

title: @entity3885 in acute XXXX and @entity944 : relation to epicardial plaque histopathology.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial microvascular emboli']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden coronary death']

entities_list: @entity2681 :: ('MESH:D014077', 'Disease') :: ['Plaque erosion']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['microvascular obstruction', 'Microemboli and microvascular obstruction']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['plaque ruptures']

entities_list: @entity1186 :: ('MESH:D003328', 'Disease') :: ['coronary thrombosis', 'Epicardial coronary thrombosis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['epicardial coronary artery plaque', 'coronary artery plaque type and cardiac microemboli']

answer: @entity1186 :: (MESH:D003328,Disease) :: ['coronary thrombosis']


abstract: From 1973 to 1989, 110 thoracotomies for metastatic @entity2 were done on 85 @entity1 , in our institution. The overall actuarial five-year survival rate was 31%. The five-year survival rate for @entity189 was 40% and for @entity242 was 11% (less than 0.05). A favorable outcome was obtained in the group with @entity5 of the breast, head-neck, and chorion. The outcome for @entity1 with @entity2721 was poor. The significant predictors of a better long-term survival for metastatic @entity2 were disease-free interval (DFI) greater than 12 months, @entity5 size less than or equal to 30 mm in diameter, and @entity5 doubling time (TDT) greater than 40 days (p less than 0.05). The number of nodules and the laterality of the sites of recurrence did not relate to survival time. Of 22 @entity1 undergoing regional lymph node dissection, seven (32%) had positive nodes. Even in cases of a recurrent @entity358 , the three-year survival in those with multiple thoracotomies was 16%. We wish to draw attention to the finding that a prolonged survival time can be achieved for @entity1 undergoing regional lymph node dissection or even repeated resections for a recurrent pulmonary metastases.

title: Metastatic XXXX and extended indications for surgery.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary metastasis']

entities_list: @entity2721 :: ('MESH:D018213', 'Disease') :: ['bone and soft tissue tumors']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung tumors']


abstract: Context     A lack of cognitive health can limit a @entity1 's well-being and may compromise independent living. The potential for @entity73 is a major concern for aging individuals. Regular physical activity has been shown to improve cognitive processes. However, functional limitations frequently prevent older adults from participating in conventional exercise programs. Given the gentle nature of mind-body exercises, interventions such as the Feldenkrais may provide an alternative. Objective     The study intended to investigate whether Feldenkrais lessons can offset @entity73 among older adults. DESIGN: The study was a case series with 2 @entity1 . Setting     The study took place in the wellness center of a retirement community. @entity1     @entity1 were 2 female residents in the community, with self-reported cognitive challenges. Intervention     The Feldenkrais method awareness through movement (ATM) was used. The lessons were based on common Feldenkrais themes, such as the relationship between eye organization and body movement, coordination of muscles, breathing, and an exploration of the @entity1 ' habits. Outcome Measures     The Trail Making Test A (TMT-A) and Trail Making Tests B (TMT-B) were used to measure cognitive function at baseline and after the Feldenkrais intervention. Results     Both @entity1 improved their performance on the TMT-A and TMT-B after completing the Feldenkrais intervention. Neither of the 2 @entity1 reported any adverse events related to the lessons. Conclusion     The beneficial results warrant further research into the efficacy of Feldenkrais as complementary, alternative therapy for preserving cognitive function on a larger scale and in populations with diagnosed @entity73 .

title: Case Report: Outcomes of Feldenkrais Movements on Self-reported XXXX in Older Adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'person']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline', 'cognitive impairments']

answer: @entity73 :: (MESH:D003072,Disease) :: ['Cognitive Decline']


abstract: OBJECTIVE: To determine level of @entity645 / @entity791 knowledge among first-year MBBS, nursing and pharmacy students of a health university. MATERIALS AND METHODS: A pre-designed, pre-tested, anonymous self-administered, semi-structured questionnaire was circulated among available 129, 53 and 55 first-year MBBS, nursing and pharmacy students during Oct' 09. Data entry, management and analysis were carried out using MS excel and software statistical package. RESULT: Out of the total 237 students, there were 123 (51.9%) female and 103 (44.0%) students from rural native place. A majority of students were able to correctly write the full form of @entity791 (95.8%) in comparison to @entity645 (72.6%) and the difference between two terminologies were known to 87.6%, 81.1% and 70.9% of MBBS, nursing and pharmacy students, respectively. All four common routes of transmission of @entity281 and methods of prevention were known to majority of the lot. However, injecting drug users (IDU) and truck driver as a risk category was correctly reported by 67.5% and 55.3% students, whereas 35.9% incorrectly mentioned that smoking is a risk factor for acquiring @entity281 . A statistically significant (P <0.05) proportion of MBBS followed by nursing and pharmacy students were aware that @entity281 neither spreads by social activities like handshake/playing nor by mosquito bite. However, low level was ascertained with regard to items related to non-curability of @entity281 (57.4%) and availability of anti-retro viral therapy (27.4%). CONCLUSION: Overall high level of knowledge was recorded in the present study with a difference noted among students in three professional streams.

title: XXXX / @entity791 knowledge among first year MBBS, Nursing, Pharmacy students of a health university, India.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity645 :: (57667,Species) :: ['HIV']


abstract: BACKGROUND: Genetic improvement in livestock populations can be achieved without significantly affecting genetic diversity if mating systems and selection decisions take genetic relationships among individuals into consideration. The objective of this study was to examine the genetic diversity of two commercial breeds of @entity1707 . Genotypes from 1168 Landrace (LA) and 1094 Large White (LW) animals from a commercial breeding program in Brazil were obtained using the Illumina PorcineSNP60 Beadchip. Inbreeding estimates based on pedigree (F x) and genomic information using runs of homozygosity (F ROH) and the single nucleotide polymorphisms (SNP) by SNP inbreeding coefficient (F SNP) were obtained. Linkage disequilibrium (LD), correlation of linkage phase (r) and effective population size ( @entity33548 ) were also estimated. RESULTS: Estimates of inbreeding obtained with pedigree information were lower than those obtained with genomic data in both breeds. We observed that the extent of LD was slightly larger at shorter distances between SNPs in the LW population than in the LA population, which indicates that the LW population was derived from a smaller @entity33548 . Estimates of @entity33548 based on genomic data were equal to 53 and 40 for the current populations of LA and LW, respectively. The correlation of linkage phase between the two breeds was equal to 0.77 at distances up to 50  kb, which suggests that genome-wide association and selection should be performed within breed. Although selection intensities have been stronger in the LA breed than in the LW breed, levels of genomic and pedigree inbreeding were lower for the LA than for the LW breed. CONCLUSIONS: The use of genomic data to evaluate population diversity in livestock animals can provide new and more precise insights about the effects of intense selection for production traits. Resulting information and knowledge can be used to effectively increase response to selection by appropriately managing the rate of inbreeding, minimizing negative effects of inbreeding @entity308 and therefore maintaining desirable levels of genetic diversity.

title: Genetic diversity analysis of two commercial breeds of XXXX using genomic and pedigree data.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

answer: @entity1707 :: (9823,Species) :: ['pigs']


abstract: @entity5153 , a new semisynthetic @entity4028 , was used in the treatment of 42 @entity1 with serious gram-negative @entity2348 . Of the 40 evaluable @entity1 , 24 (60%) were cured, and 8 (20%) had a favorable clinical response, for a total clinical response rate of 80%. Eight @entity1 failed to respond; of these, three had undrained abscesses and two had severe @entity3028 . Three of the @entity1 who failed had organisms in which resistance to @entity5153 developed during therapy, and in two of these three @entity5153 was the only @entity4028 to which resistance developed. Of the 37 @entity1 evaluable for @entity137 , 8 (22%) developed @entity177 . Two @entity1 had mild but persistant elevation in serum @entity1011 . Three @entity1 had nephrotoxicity while on @entity801 in the past. Pre- and posttherapy audiograms were done on 26 @entity1 ; none had @entity393 . Four @entity1 had mild, transient asymptomatic elevations in alkaline phosphatase. The pretreatment clinical isolates were tested for in vitro susceptibility. The median minimal inhibitory concentration of @entity5153 , @entity801 , and @entity2890 ranged between 0.5 and 2 mug/ml. The median minimal inhibitory concentration of @entity4509 was approximately twofold higher. No clear in vitro superiority of one @entity4028 over another was observed.

title: XXXX in gram-negative @entity2348 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2890 :: ('MESH:D014031', 'Chemical') :: ['tobramycin']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections']

entities_list: @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin']

entities_list: @entity5153 :: ('MESH:D009428', 'Chemical') :: ['netilmicin', 'Netilmicin']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia']

entities_list: @entity4028 :: ('CHEBI:47779', 'Chemical') :: ['aminoglycoside']

answer: @entity5153 :: (MESH:D009428,Chemical) :: ['Netilmicin']


abstract: STUDY DESIGN: Consecutive case series cohort. OBJECTIVE: To determine the relative frequencies of the spine, the sacroiliac (SI) joint, and the hip joint being the primary @entity158 generator among @entity1 presenting at a spine surgery clinic for @entity1643 ( @entity1643 ). SUMMARY OF BACKGROUND DATA: Identification of the primary @entity158 generator in a @entity1 with @entity1643 is difficult. Possible @entity158 sources include the lumbar spine, the @entity2720 . Their relative frequencies among @entity1 presenting at a spine surgeon's clinic have not been well established. METHODS: Three hundred sixty-eight new @entity1 were seen at a single spine surgeon's clinic during a 10-month period. Of these, 289 (78.5%) complained primarily of @entity1643 with or without leg @entity158 . Seventy-seven had previous surgery. The remaining 200 cases were reviewed for all diagnostic tests performed, as well as the final diagnosis. RESULTS: One hundred sixty-four (82%) had spine pathology, but only 130 (65%) had spine-only pathology, whereas 35 (17.5%) had a combination of spine plus hip and/or SI joint pathology. An additional 16 (8%) had hip and/or SI joint pathology without spine pathology. Twenty (10%) had an undefined @entity158 source. Overall, 25 (12.5%) had hip pathology, and 29 (14.5%) had SI joint pathology. CONCLUSION: For @entity1 presenting to a spine surgeon's clinic for @entity1643 , up to 25% of @entity1 may have significant @entity158 contribution from the hip or @entity2720 , and an additional 10% will still have an undefined @entity158 source even after diagnostic workup. This underscores the need for clinicians to be aware of nonspinal @entity158 generators and to appropriately pursue alternative diagnoses.

title: How often is XXXX not coming from the back?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'LBP']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['SI joint, and the hip joint', 'SI joints']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: Metastatic variants of @entity1 @entity263 cell lines (DU-145, LNCaP, and ND-1) were studied by using soft agar colony forming efficiency, @entity19 tumorigenicity, in vitro invasion assay, and @entity1235 assay. The DU-145 and ND-1 cell line showed higher metastatic potential than LNCaP. Lipids from DU-145, ND-1, and LNCaP cells were extracted and analyzed by thin-layer chromatography and gas-liquid chromatography. The major lipids were @entity2434 , @entity3633 , @entity4291 , @entity1718 , and @entity165 . The @entity4291 level was significantly higher in highly metastatic cells (DU-145 and ND-1) compared with the lower metastatic variant (LNCaP). The increase in the synthetic pathway and decrease in degradation pathway of @entity4291 in microsomal fractions was sufficient to account for the measured increase in @entity4291 in DU-145 cells compared with LNCaP cells. The major @entity1718 of these lipids were palmitic (16:0), stearic (18:0), oelic (18:1), and @entity1426 (20:4). The @entity1426 level was significantly decreased in DU-145 and ND-1 compared with LNCaP cells. Electron microscopic studies showed no significant changes in the morphology of DU-145, ND-1, and LNCaP cells. The results of these investigations demonstrate for the first time that @entity4291 and @entity1426 contents are different in high and low metastatic variants of @entity1 @entity263 cell lines.

title: Metastasis-associated alterations in phospholipids and XXXX of @entity1 @entity263 cell lines.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic adenocarcinoma']

entities_list: @entity2434 :: ('MESH:D010713', 'Chemical') :: ['phosphatidylcholine']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity3633 :: ('MESH:C483858', 'Chemical') :: ['phosphatidylethanolamine']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity4291 :: ('CHEBI:17636', 'Chemical') :: ['sphingomyelin']

answer: @entity1718 :: (MESH:D005227,Chemical) :: ['fatty acids']


abstract: BACKGROUND: Exposure to cat and @entity235 allergens is very common in the Western World and is a serious cause of @entity565 in sensitized subjects. OBJECTIVE: We sought to study the clinical effects of air cleaners in living rooms and bedrooms of @entity748 @entity1 sensitized to cat or @entity235 allergens. METHODS: Twenty @entity748 @entity1 sensitized to pet allergens (cat/ @entity235 ) and with an animal at home participated in a double-blind, placebo-controlled, cross-over study in which the effects of air cleaners placed in the living room and bedroom for 3 months were compared with the effects of sham air cleaners. Before and after each study period, lung function, airway hyperresponsiveness ( @entity860 ), and peak flow variation were recorded. Cat and @entity235 allergen levels were assessed in the filters of the air cleaners. RESULTS: After a 3-month intervention with active air cleaners, airway hyperresponsiveness decreased significantly, showing a 1.2 doubling dose increase of PC(20 ) @entity859 (P =.003). Peak flow amplitude also decreased (P =. 045). Substantial amounts of airborne cat and @entity235 allergen were captured by the air cleaners in living rooms and bedrooms as well. Allergen levels in floor dust were not changed. CONCLUSION: In young @entity748 @entity1 sensitized and exposed to pets in the home, application of air cleaners in living rooms and bedrooms was accompanied by a significant improvement in airway hyperresponsiveness and a decrease in peak flow amplitude.

title: Clinical effects of air cleaners in homes of XXXX @entity1 sensitized to pet allergens.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity860 :: ('MESH:D000249', 'Chemical') :: ['adenosine monophosphate']

answer: @entity748 :: (MESH:D013224,Disease) :: ['asthmatic']


abstract: An @entity2875 of the nasopharynx of a 10 year old @entity1 is analysed with light and electron microscopy. With regard to cell shape and cytoplasmic features the following four @entity5 cell types could be distinguished: 1. Undifferentiated mesenchymal cells with a big loosely packed nucleus and a small cytoplasmic rim with only few cell organelles; 2. Undifferentiated @entity5 cells with a broad cytoplasmic body which contains a dense network of nonspecific intermediate filaments with a diameter of about 100 A; 3. Immature rhabdomyoblasts with randomly orientated specific myofilaments; 4. Fully differentiated rhabdomyoblasts with well developed myofibrils often showing a sarcomeric pattern. Glycogen deposits which were seen in great masses in many @entity5 cells were regarded to result from @entity5 . The cellular stages in the development of rhabdomyoblasts are basically identical to those known from the embryogenesis and regeneration of striated muscle. From these observations the two following developmental pathways are suggested: 1. Origin of the @entity5 from an undifferentiated mesenchymal @entity27447 . Atypical regeneration of striated muscle which terminates in malignant progressive @entity5 growth. At present, the body of information about @entity980 supports the assumption of an origin from immature mesenchymal cells. Nevertheless, the second theory cannot be totally excluded.

title: [Ultrastructure and formal pathogenesis of XXXX (author's transl)].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['degenerative processes within the tumor', 'tumour']

entities_list: @entity2875 :: ('MESH:D018233', 'Disease') :: ['embryonal rhabdomyosarcoma']

entities_list: @entity980 :: ('MESH:D012208', 'Disease') :: ['rhabdomyosarcomas']

answer: @entity2875 :: (MESH:D018233,Disease) :: ['embryonal rhabdomyosarcoma']


abstract: OBJECTIVE: To study the efficacy, safety, and compliance of short-term electro-acupuncture for @entity1 with @entity72 ( @entity72 ). DESIGN: Randomized, double-blind, sham-controlled, clinical trial. SUBJECTS AND METHODS: @entity1 with @entity72 were randomly assigned to an electro-acupuncture (EA) group (n=30) or a sham electro-acupuncture (SEA) group (n=25) matched by age and severity of @entity2438 . The EA group received electro-acupuncture for selected acupoints while the SEA group received sham electro-acupuncture to sham acupoints. A total of 12 EA and SEA sessions over four weeks were given. Primary outcome measures included Functional Independence Measure for @entity1 (WeeFIM), Pediatric Evaluation of Disability Inventory (PEDI), Leiter International Performance Scale-Revised (Leiter-R), and Clinical Global Impression-Improvement (CGI-I) scale. Secondary outcome measures consisted of Aberrant Behavior Checklist (ABC), Ritvo-Freeman Real Life Scale (RFRLS), Reynell Developmental Language Scale (RDLS), and a standardized parental report. Data were analyzed by the Mann-Whitney test. RESULTS: There were significant improvements in the language comprehension domain of WeeFIM (p=0.02), self-care caregiver assistant domain of PEDI (p=0.028), and CGI-I (p=0.003) in the EA group compared to the SEA group. As for the parental report, the EA group also showed significantly better social initiation (p=0.01), receptive language (p=0.006), motor skills (p=0.034), coordination (p=0.07), and attention span (p=0.003). More than 70 percent of @entity1 with @entity72 adapted to acupuncture easily, while eight percent had poor acupuncture compliance. Mild side effects of minor superficial @entity548 or @entity146 during acupuncture were observed. CONCLUSION: A short, four-week (12 sessions) course of electro-acupuncture is useful to improve specific functions in @entity1 with @entity72 , especially for language comprehension and self-care ability.

title: Randomized controlled trial of electro-acupuncture for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder']

answer: @entity72 :: (MESH:D002659,Disease) :: ['autism spectrum disorder']


abstract: OBJECTIVE: To evaluate the influence of @entity2973 / @entity28 on the incidence of @entity101 among adults in China. METHODS: The subjects of this prospective study were 13 739 Chinese adults aged 35-74 years recruited at the baseline surveys of China Multicenter Collaborative Study of @entity65 Epidemiology and International Collaborative Study of @entity65 in Asian. Baseline surveys were conducted in 1998 and during 2000-2001, respectively, and the follow-up was conducted during 2007-2008. According to the body mass index, the subjects were divided into four groups: underweight group(<18.5 kg/m(2)), normal weight group(18.5-23.9 kg/m(2)), @entity2973 group(24.0-27.9 kg/m(2))and @entity28 group(>= 28.0 kg/m(2)). Age-standardized cumulative incidence of @entity101 was calculated for each group, respectively. The relative risks(RRs)and 95% confidence intervals(CIs)for the incidence of @entity101 of underweight, @entity2973 and @entity28 groups were estimated by using generalized linear regression model with normal weight group as reference. RESULTS: During 8.1 years of follow-up, 4 271 @entity101 cases were detected(2 012 in @entity1 and 2 259 in @entity1 ). Age-standardized cumulative incidence of @entity101 for the underweight, normal weight, @entity2973 and @entity28 groups were 20.3%, 30.9%, 43.6% and 50.8% in @entity1 , respectively; and 22.9%, 30.4%, 41.1% and 50.8% in @entity1 , respectively. Compared with the normal weight group, multivariate-adjusted RR(95% CI)for the incidence of @entity101 in underweight, @entity2973 and @entity28 groups were 0.78(0.64-0.95), 1.22(1.13-1.30)and 1.28(1.16-1.42)in @entity1 , respectively; and 0.89(0.77-1.03), 1.16(1.09-1.23)and 1.28(1.18-1.38)in @entity1 , respectively. The @entity2973 and @entity28 subjects had higher risk for the incidence of @entity101 , with the population attributable risk proportion of 7.4% in @entity1 and 8.8% in @entity1 , respectively. CONCLUSION: Overweight or @entity28 @entity1 are at an increased risk of developing @entity101 , thus prevention and control of @entity2973 / @entity28 are needed to reduce @entity101 incidence among adults in China.

title: [Relationship between @entity2973 / @entity28 and XXXX among adults in China: a prospective study].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'people', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity2973 :: ('MESH:D050177', 'Disease') :: ['overweight']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular Disease']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: PURPOSE: @entity700 is often diagnosed in @entity1 with @entity1412 , because they frequently undergo abdominal imaging and have a raised incidence of @entity700 . This study investigates the natural history of @entity700 in @entity1412 , and suggests a schema for management. METHODS: An original cohort of 14 @entity1412 @entity1 with @entity700 , identified prospectively 12 years ago, was followed up clinically and radiologically. A further group of 16 @entity1 was also identified. All had lesions >1 cm. For both cohorts, characteristics of @entity1 (genotype, age at diagnosis, concomitant diagnoses) and incidentaloma (size, laterality, rate of growth, outcome) are described. RESULTS: Overall, 3 of 30 @entity1 underwent adrenalectomy; one @entity1 had @entity1911 and another had an @entity652 of borderline @entity5 . A further three lesions were radiologically suspicious for @entity5 at the time of diagnosis; one was in a @entity1 who was unfit for surgery but died of nonadrenal causes after nine years. None of the lesions radiologically benign at diagnosis showed an aggressive course, but one @entity1 required referral for surgery after 12 years because of a slow increase in size of the lesion. There were no associations with genotype. CONCLUSIONS: @entity1412 -associated @entity700 may warrant long-term follow-up. Although the natural history is similar to lesions occurring sporadically, these @entity1 have concomitant @entity1412 -associated manifestations under radiologic surveillance. In this rare condition, development of a robust protocol will require evidence from worldwide @entity1 cohorts. However, a tailored schema is suggested as a consistent basis for future modification.

title: @entity700 in XXXX : a long-term follow-up study and schema for management.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1911 :: ('MESH:D010673', 'Disease') :: ['pheochromocytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis', 'Familial adenomatous polyposis']

entities_list: @entity700 :: ('MESH:C538238', 'Disease') :: ['adrenal incidentaloma', 'Adrenal incidentaloma']

answer: @entity1412 :: (MESH:D011125,Disease) :: ['familial adenomatous polyposis']


abstract: Pharmacokinetics and clinical effects were studied in a combination therapy with @entity5646 ( @entity5647 ) and @entity869 (ABPC) in neonates and premature @entity1 . The results obtained are summarized as follows. 1. Pharmacokinetics (1) Average serum concentrations at 30 minutes after one-shot intravenous injection of @entity5647 20 mg/kg and ABPC 25 mg/kg to a 4-7 days age-group of neonates were 41.3 ( @entity5647 ) and 30.5 (ABPC) micrograms/ml, respectively. They gradually decreased to 14.7 and 2.7 micrograms/ml at 6 hours after the administration, but the concentration of @entity5647 was always higher than that of ABPC. (2) Serum half-lives (T1/2) in the 4-7 days age-group were 3.61 hours for @entity5647 and 1.42 hours for ABPC, thus T1/2 of @entity5647 was longer. However, T1/2 of @entity5647 was scarcely affected in the concomitant administration of ABPC. (3) Urinary excretion of @entity5647 in the concomitant administration to the 4-7 days age-group was 52.7%, which was the same or a little higher comparing to that in @entity5647 alone administration. 2. Clinical studies (1) @entity5647 and ABPC were concomitantly administered to 160 cases and 133 cases were evaluated for efficacy. Pathogenic organisms were identified in 29 cases (Group A) and the efficacy rate was 86.2% (25/29). The number of cases in which pathogenic organisms were not identified (Group B) was 50 and in this group, the efficacy rate was excellent, 94.0% (47/50). @entity5647 and ABPC were concomitantly administered to 54 cases for prophylaxis and in all the cases the administrations showed prophylactic effect. (2) Bacterial changes were confirmed in 21 of the 29 cases in which pathogenic organisms were identified initially and all of these 21 cases showed bacterial eradication, i.e., the bacterial eradication rate in the treatment was 100%. (3) There were 2 cases in which side-effects were observed among the analyzed 152 cases (1.3%). The side effects found were 1 case each of @entity294 and @entity203 . Abnormal laboratory values were found in 23 cases (15.9%), i.e., @entity1712 (9 cases), platelet-increase (4), elevation of GOT (4), elevation of GOT and GPT (3) and others (3). From the above pharmacokinetics and clinical results, the combination therapy of @entity5647 and ABPC is considered to be one of the useful empiric antibiotic-therapies when pathogenic organisms are unknown in the infections of neonates and premature @entity1 .

title: [Pharmacokinetics and clinical studies on @entity5646 in neonates and premature XXXX (the second report). Study on effectiveness and safety in combination therapy using @entity5646 and @entity869 . A study of @entity5646 in the Perinatal Co-research Group].

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity203 :: ('MESH:D003875', 'Disease') :: ['eruption']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin']

entities_list: @entity5646 :: ('MESH:D001398', 'Chemical') :: ['aztreonam']

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: We report the response of ten @entity1 (6 male, 4 female) with @entity134 -resistant @entity628 ( @entity628 ) to treatment with intravenous pulse @entity786 (IVCP) together with oral @entity229 . All @entity1 had been treated with 60 mg/m2 oral @entity229 daily for 2 months upon initial presentation. IVCP was given monthly at a dose of 500 mg/m2 over 6 months. Oral @entity229 was given concurrently at 60 mg/m2 daily for 2 months and then on alternate days for 4 months, followed by 30 mg/m2 on alternate days for 6 months. @entity229 was then tapered monthly by 10 mg and finally discontinued. Five @entity1 failed to respond to @entity230 from the onset and were considered as primary @entity134 resistant. Two of these @entity1 achieved sustained remission after IVCP, one @entity1 showed a partial response, with loss of @entity4 , normalization of serum albumin, and persistent @entity644 , while two @entity1 showed no response to IVCP. The other five @entity1 had achieved remission after 2 months of daily @entity229 at 60 mg/m2 upon initial presentation, but had suffered from more than three relapses per year and had eventually become @entity134 resistant. They were considered secondary @entity134 resistant. All five @entity1 achieved sustained remission after IVCP. None of our @entity1 suffered from adverse effects of IVCP. We suggest IVCP as an adjunctive therapy for @entity134 -resistant @entity628 , particularly for @entity1 with secondary @entity134 resistance.

title: Pulse @entity786 for @entity134 -resistant XXXX .

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone', 'Prednisone']

entities_list: @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis', 'FSGS']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity628 :: (MESH:D005923,Disease) :: ['focal segmental glomerulosclerosis']


abstract: PURPOSE: To review experiences in the treatment of regionally advanced @entity320 to the neck and/or parotid with emphasis on the role of adjuvant radiotherapy. @entity1 AND METHODS: Clinical and histopathologic data, treatment details, and outcomes in @entity1 treated during the period 2000-2006 at the Institute of Oncology, Ljubljana, Slovenia, were reviewed. RESULTS: A total of 40 @entity1 with 42 dissections underwent surgery, and 43 @entity1 with 45 dissections received irradiation postoperatively to a median equivalent dose (eqTD(2): 2 Gy/fraction, 1 fraction/day, 5 fractions/week) of 60 Gy (range, 47.8-78.8). Regional control 2 years after surgery was 56% (95% confidence interval [CI] 40-72%) and after postoperative radiotherapy 78% (CI 63-92%) (p = 0.015). On multivariate analysis, postoperative radiotherapy (yes vs. no: hazard ratio [HR] 6.3, CI 2.0-20.6) and sum of the risk factors present (i.e., risk factor score; HR 1.7 per score point, CI 1.2-2.6) were predictive for regional control. On logistic regression testing, the number of involved nodes was associated with the probability of distant metastases (p = 0.021). The incidence of late @entity137 did not correlate with the mode of therapy, eqTD(2), or fractionation pattern. CONCLUSIONS: Adjuvant radiotherapy has the potential to compensate effectively for the negative impact of adverse histopatologic features to disease control in a dissected nodal basin. More conventionally fractionated radiotherapy regimens using fraction doses of 2-2.5 Gy, with cumulative eqTD(2)> or =60 Gy, are recommended. The number of involved lymph nodes is proposed as an additional criterion for limiting the implementation of adjuvant irradiation.

title: XXXX metastases to the neck nodes: role of adjuvant irradiation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Melanoma']


abstract: @entity1150 of the lower extremities is an uncommon but dreaded complication of pregnancy which can present diagnostic and therapeutic problems to the treating physician. From January 1, 1985, to December 31, 1988, 7867 deliveries were performed at St. Luke's Hospital. Five of these @entity1 were pregnant @entity1 who were treated for @entity1150 of the lower extremities. The @entity1 were either in their second or third trimester of pregnancy. The clinical diagnosis in each case was confirmed with duplex ultrasonography. Each @entity1 was treated with 7 to 10 days of intravenous heparin therapy and then discharged on subcutaneous heparin therapy. There were no bleeding complications related to the heparin therapy. No @entity1 developed a @entity1151 . Each @entity1 delivered a normal @entity1 . The only complication was a heparin induced @entity1910 in one @entity1 which resolved when a different preparation of heparin was used. The management of @entity1150 in pregnancy is discussed.

title: Management of XXXX in the pregnant female.

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis', 'Deep venous thrombosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'women', 'patients', 'patient']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep venous thrombosis']


abstract: Definition of improved therapeutic regimens of interferon-alpha ( @entity3027 ) for the treatment of @entity2826 ( @entity2826 ) would be useful since currently recommended doses are sometimes associated with unacceptable @entity137 . IFN concentrations were measured in serum samples from @entity1 with @entity791 -associated @entity2826 who were enrolled in a trial of @entity3027 alone (16 @entity1 ) or a trial of @entity3027 combined with @entity9611 (25 @entity1 ). Analyses were done to examine the relationship between the dose of @entity3027 , blood level of IFN, and the @entity1 's clinical response to treatment. There was no correlation between dose of @entity9611 given and response. As expected, there was a high correlation between dose of @entity3027 and blood level in both studies (p less than 0.001). Furthermore, we found relationships between clinical response and both dose of @entity3027 and blood level achieved. In the two studies combined, among @entity1 with greater than 200 CD4+ cells/mm3 of blood at baseline on average daily doses of greater than or equal to 10 million international units (MIU) of @entity3027 , 13/19 (68%) responded compared to 6/17 (35%) on less than MIU (p = 0.05). Similarly, of @entity1 with IFN blood levels greater than or equal to 100 IU/mL 12/16 (75%) responded compared to 7/20 (35%) of those with blood levels less than 100 IU/mL (p = 0.02). The dose and blood levels of IFN achieved and maintained may be important factors in determining responses of @entity2826 . Additional clinical trials of @entity3027 treatment of @entity2826 at doses about 10 MIU/day appear warranted.

title: Effects of interferon-alpha in XXXX with @entity791 -associated @entity2826 are related to blood interferon levels and dose.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity2826 :: ('MESH:D012514', 'Disease') :: ["Kaposi's sarcoma", 'KS']

entities_list: @entity9611 :: ('MESH:D015215', 'Chemical') :: ['zidovudine']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity11989 ( @entity2026 or neglect) are a regular concomitant symptom of cortical, and, occasionally, subcortical @entity2806 . In 19 @entity1 with @entity75 (eight with @entity11989 , 11 without @entity11989 ), F/V-SPECT was employed to search for changes in @entity16417 in both, lesions and ipsilateral cortex. Results were correlated with @entity11989 and MRI findings. Compared to the unaffected hemisphere, all @entity75 showed reduced regional cerebral blood flow ( @entity13279 ) (-16 to -23%), increased regional cerebral blood volume (rCBV) (+34 to +62%), and decreased or missing @entity16417 (-27 to -28%). Compared to MRI, there was no difference in lesion size in the @entity1031 . Hemodynamic low-flow @entity1188 , however, were greater with SPECT than in MRI. In @entity1 without @entity11989 , the adjacent cortex was normal in SPECT and MRI. In addition, @entity1 with @entity11989 revealed reduced @entity13279 (-18%), increased rCBV (+19%), and decreased @entity16417 (-22%) in the adjacent cortex. MRI was normal in the same cortical area. These results indicate that @entity11989 in @entity75 may be caused by a hemodynamic mechanism causing reduction of @entity16417 in the adjacent cortex.

title: [Determination of regional cerebrovascular perfusion reserve ( @entity16417 ) using quantitative flow/volume (F/V)-SPECT. Results in @entity1 with subcortical XXXX with or without neuropsychological symptoms].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['subcortical lesions']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic lesions']

answer: @entity75 :: (MESH:D001927,Disease) :: ['ischemic brain lesions']


abstract: Marine @entity2199 that carry @entity599 -oxidizing bacteria on their cuticle (Stilbonematinae, Desmodoridae) migrate between oxidized and reduced sand layers thereby supplying their symbionts with @entity26 and @entity3287 . These symbionts, in turn, constitute the worms' major food source. Due to the accessibility, abundance and relative simplicity of this association, stilbonematids may be useful to understand symbiosis establishment. Nevertheless, only the symbiont of Laxus oneistus has been found to constitute one single phylotype within the Gammaproteobacteria. Here, we characterized the symbionts of three yet undescribed @entity2199 that were morphologically identified as members of the genus Robbea. They were collected at the island of Corsica, the Cayman Islands and the Belize Barrier Reef. The surface of these worms is covered by a single layer of morphologically undistinguishable bacteria. 18S rDNA-based phylogenetic analysis showed that all three species belong to the Stilbonematinae, although they do not form a distinct cluster within that subfamily. 16S rDNA-based analysis of the symbionts placed them interspersed in the cluster comprising the @entity599 -oxidizing symbionts of L. oneistus and of marine gutless oligochaetes. Finally, the presence and phylogeny of the aprA gene indicated that the symbionts of all three @entity2199 can use reduced @entity599 compounds as an energy source.

title: Molecular characterization of the symbionts associated with marine XXXX of the genus Robbea.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3287 :: ('CHEBI:26822', 'Chemical') :: ['sulfide']

answer: @entity2199 :: (6239,Species) :: ['nematodes']


abstract: The factors that promote the localized bone resorption by @entity2968 ( @entity1777 ) are not fully understood. We investigated whether T cells could contribute to bone resorption by stimulating expression of genes for @entity4293 ( @entity4293 ), matrix metalloproteinase (MMP)-13, and the @entity5298 ( @entity5298 ). Two cell lines, Jurkat clone E6-1 and D1.1, were co-cultured with isolated @entity1777 stromal cells. Real-time PCR analyses demonstrated a significant increase of all three genes following 48h incubation, and @entity4293 and @entity1550 gene expression was also increased at 24h. Further, we examined the expression of @entity11603 ( @entity11603 ), a protein expressed by activated T cells, and its receptor, @entity2936 , in @entity1777 . Immunohistochemistry results revealed expression of the @entity2936 receptor in both the stromal cells and giant cells of the @entity5 . RNA collected from whole @entity1777 tissues showed expression of @entity11603 , which was absent in cultured stromal cells, and suggests that @entity11603 is expressed within @entity1777 . Stimulation of @entity1777 stromal cells with @entity11603 significantly increased expression of the @entity4293 and @entity1550 genes. Moreover, we show that inhibition of @entity4293 with neutralizing antibodies significantly decreased @entity1550 expression by the stromal cells compared to IgG-matched controls, whereas stimulation with @entity4293 (1-34) increased @entity1550 gene expression. These results suggest that T cells may potentiate the catabolic effect of @entity1777 .

title: T cells stimulate catabolic gene expression by the stromal cells from XXXX .

entities_list: @entity2968 :: ('MESH:D018212', 'Disease') :: ['giant cell tumor of bone']

entities_list: @entity4293 :: ('5744', 'Gene') :: ['PTHrP', 'parathyroid hormone-related protein']

entities_list: @entity5298 :: ('8600', 'Gene') :: ['RANKL', 'receptor activator of nuclear-factor kB ligand']

answer: @entity2968 :: (MESH:D018212,Disease) :: ['giant cell tumor of bone']


abstract: The present studies investigated the expression of the two PDGF genes ( @entity6006 / @entity6006 and @entity6005 ) and the PDGF-receptor b gene ( @entity3820 ) in 34 primary @entity1 @entity816 . Northern blot analysis demonstrated the coexpression of the @entity6006 / @entity6006 protooncogene and the @entity3820 gene in all @entity816 examined. The majority of the @entity5 also expressed the @entity6005 gene. There was no correlation between the expression of the two PDGF genes. Nonmalignant @entity1 brain tissue expressed the @entity3820 and @entity6005 genes but not the @entity6006 / @entity6006 protooncogene. In situ hybridization of @entity816 tissue localized the expression of the @entity6006 and @entity3820 mRNA's in @entity5 cells. Capillary endothelial cells also expressed @entity6006 mRNA. In contrast, nonmalignant @entity1 brain tissue expressed only @entity3820 mRNA but not @entity6006 / @entity6006 mRNA. The coexpression of a potent mitogenic growth factor protooncogene ( @entity6006 ) and its receptor gene in @entity5 cells suggests the presence of an autocrine mechanism that may contribute to the development and maintenance of @entity816 . The expression of @entity6006 mRNA in @entity5 cells but not in nonmalignant brain cells may serve as an additional diagnostic criterion for the detection of @entity816 in small tissue specimen using in situ hybridization for the detection of @entity6006 mRNA and/or immunostaining for the recognition of its protein product.

title: Coexpression of platelet-derived growth factor (PDGF) and PDGF-receptor genes by primary @entity1 XXXX may contribute to their development and maintenance.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'astrocytoma tumor']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma', 'astrocytomas']

answer: @entity816 :: (MESH:D001254,Disease) :: ['astrocytomas']


abstract: BACKGROUND: @entity1 and adolescents with injuries resulting in @entity174 are a population that is potentially at risk for suffering concomitant concussion. Concussion results in a variety of physical symptoms and often affects cognition, emotion, and sleep. These effects can have a significant impact on academics and social functioning. Early recognition of concussion and active management have been shown to improve outcomes. The goal of this study was to describe the occurrence of concussion in @entity1 sustaining @entity174 and to determine whether certain @entity174 types are associated with concussion. METHODS: We performed a retrospective review of @entity1 aged 0 to 18 years who were evaluated in the emergency department of the @entity1 's Hospital of Pittsburgh from 2000 to 2005 with an International Classification of Diseases, Ninth Revision code indicative of @entity174 . Data included demographics, documentation of concussion, and @entity174 . @entity1 with @entity1504 were excluded from the study. Univariate   2 analysis and logistic regression were performed to determine characteristics associated with concussion. RESULTS: @entity174 was diagnosed in 782 @entity1 . Ninety-one @entity1 had an @entity1504 and were excluded, leaving 691 @entity1 for evaluation. The mean age was 11.1 (SD, 4.6) years. Males made up 69.6% of @entity1 , and 80.6% of @entity1 were white. Concussion was diagnosed in 31.7% of @entity1 . Age, sex, and race were not associated with concussion. Univariate analysis demonstrated that skull and orbital @entity174 were associated with higher rates of concussion, whereas @entity174 showed a trend toward higher rates of concussion, and nasal and mandible @entity174 showed a trend toward lower rates of concussion. Logistic regression analysis demonstrated the odds of having a concussion were higher in those with @entity174 (odds ratio, 2.3; confidence interval, 1.5-3.7). CONCLUSIONS: Nearly one third of pediatric @entity1 with @entity174 in this retrospective series were diagnosed with a concomitant concussion. Our data suggest that a higher index of suspicion for concussion should be maintained for @entity1 with concomitant @entity174 and potentially orbital and @entity174 . Given the possibility of a worse outcome with delayed concussion diagnosis, @entity1 with @entity174 may benefit from more active early concussion screening.

title: XXXX : occurrence of concussion and relation to @entity174 patterns.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Children']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'Facial fracture', 'skull fractures', 'facial fractures', 'maxillary fractures', 'fracture', 'facial fracture type']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial injury']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Pediatric facial fractures']