abstract: PURPOSE: To investigate mortality and especially the incidence of @entity944 ( @entity944 ) in a population-based cohort of @entity302 surgery @entity1 . METHODS: All @entity1 who underwent @entity302 surgery treatment between January 1990 and December 1998 (surgery @entity1 ) or whose presurgical evaluation started, although not leading to an operation, during the same period (nonsurgery @entity1 ) were identified through the Swedish National @entity302 register. All subjects were followed up through the Cause of Death Register until December 1998. Standardized mortality ratios (SMRs) for all causes of @entity204 and incidence of @entity944 were calculated. RESULTS: During the study period, 651 surgical operations were carried out on 596 @entity1 (316 male). Of those, 14 @entity1 died (six in @entity944 ), rendering a total SMR of 4.9 [95% confidence interval (CI), 2.7-8.3]. @entity944 incidence was 2.4 per 1,000 @entity1 years. No major differences were found in SMRs or @entity944 rates between subgroups when stratifying for type of operation and for @entity410 outcome 2 years after surgery. SMR and @entity944 rates were higher in right-sided temporal lobe resections for @entity5219 than in left-sided, but the number of deaths was small. Among 212 nonsurgery @entity1 , five died (four in @entity944 ). The SMR for all causes was 7.9 (2.6-18.4), and @entity944 incidence, 6.3 per 1,000 @entity1 years. CONCLUSIONS: In this large and strictly population-based cohort, SMR for all causes and @entity944 incidence among surgery @entity1 were similar to those of other studies. No differences in overall mortality emerged by @entity410 outcome, but none of the @entity944 cases was @entity410 free at the time of @entity204 . Four of five deaths in the nonsurgery group occurred during the surgery evaluation period. Mortality appeared to be lower for surgery than for nonsurgery @entity1 , and the interpretation of this finding is discussed.

title: Mortality in a population-based cohort of XXXX surgery @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden unexpected death in epilepsy', 'SUDEP']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'Epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: Recent studies in rodent models and in @entity1 have shown that the status of both the gonadal and adrenal axes (hypothalamic-pituitary-gonadal, HPG and hypothalamic-pituitary-adrenal, HPA, respectively) can influence learning and memory function. In this article, the effects of activating the @entity2270 (stress) on performance of memory tasks in @entity35 are reviewed. More importantly, results are presented which show that chronic stress has a different impact on performance of these tasks depending upon the sex of the @entity35 . These observations are novel and potentially important since few studies, animal or @entity1 , have utilized females as subjects in studies of the stress response. Sex differences in the effects of chronic stress on memory were investigated in @entity35 using an object recognition task and two spatial memory tasks, radial arm maze and object location. Given the same chronic stress--21 days of restraint for 6 h each day--males were impaired in all of the memory tests while females showed enhanced performance of the spatial memory tasks and no changes in object recognition performance. Levels of neurotransmitters and metabolites were measured in brain areas important for cognition in the subjects in order to determine neural systems that may respond to stress and mediate the cognitive responses. These results show that responses of @entity1154 and @entity535 containing neural systems may contribute to or underlie sex differences in stress effects on cognition. Stress decreased dopaminergic activity in the frontal cortex and amygdala of males but not females; whereas, in @entity1251 of the hippocampus, stress increased levels of @entity750 and @entity1063 in females, but not males, and increased @entity1246 in males, but not females. Finally, a possible role for @entity53 in mediating sexually differentiated responses to stress was examined. Behavioral and neurochemical evaluations in ovariectomized, stressed females, with or without @entity172 replacement, suggest that sex differences in response to stress are influenced by both the organizing and activating effects of @entity53 . A few, recent studies in @entity1 , that show sexually dimorphic relationships between chronic stress and cognition, are also highlighted. These results in @entity1 are consistent with the pattern of results in @entity35 . Clearly, further studies are necessary to substantiate sex differences in stress effects on memory function in @entity1 and to understand mechanisms whereby @entity172 may influence the stress response in @entity35 . Nonetheless, recent studies show sexually differentiated cognitive responses to chronic stress and underline the importance of considering the sex/gender of subjects when studying the stress response.

title: Sex differences in chronic stress effects on memory in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamine']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Few studies have analyzed the course of neurocognition in treated @entity1 and adolescents with early-onset @entity162 (EOBD) and shown improvements in @entity2414 after treatment. The aim of this study was to determine the progress over two years in neuropsychological performance of a sample of medicated adolescents with EOBD compared to @entity23 ( @entity23 ). METHODS: Twenty adolescents, diagnosed in clinical setting as DSM-IV @entity162 , treated for two years, euthymic, and 20 gender and age-matched @entity23 were assessed at two moments in @entity2414 , speed, @entity227 and executive function. Multivariate analyses of variance was carried out to analyze the differences between groups over time, and to monitor the influence of @entity716 symptoms and type of mood-stabilizer. RESULTS: The entire sample improved on verbal and visual memory tests (verbal recall p<0.01; visual recall p<0.001). Moreover, @entity1 improved more than controls in verbal reasoning (p<0.01), working memory (p<0.01), processing speed (p<0.01) and @entity227 (p<0.001). @entity716 and treatment with @entity1091 were associated with poorer development in executive control tasks. LIMITATIONS: Sample size was small and groups were re-evaluated in slight different follow-up periods. Doses of antipsychotics drugs over time were not controlled. CONCLUSIONS: Processing speed and @entity227 in the EOBD group normalized during follow-up. Executive functioning, working @entity2414 impaired in @entity1 versus controls. The knowledge of @entity73 due to normal course of @entity221 or to drug effects allows better therapeutic strategies.

title: Two-year follow-up of treated adolescents with early-onset XXXX : Changes in neurocognition.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-motor skills']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['healthy controls', 'HC']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['Psychotic symptoms', 'psychotic']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['reasoning, verbal and visual memory, working memory', 'memory, and verbal and visual memory remained', 'attention, working memory, and verbal memory']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']


abstract: BACKGROUND: @entity520 ( @entity520 ) is a frequent complication in advanced @entity177 ( @entity177 ). Currently, there is good evidence that @entity520 contributes to @entity3147 in @entity177 @entity1 . METHODS: We evaluated the effect of correcting @entity520 on nutritional status after 6 months of oral @entity4388 supplementation in 18 @entity1 aged 73 +/- 6 years with @entity177 to maintain serum @entity3157 levels at 24 +/- 2 mmol/L. The following parameters were measured: dietary record, energy intake, dietary protein intake (DPI), mini-nutritional assessment (MNA), serum albumin level, prealbumin level, prognosis inflammatory and nutritional index (PINI), and protein catabolic rate ( @entity14588 ). RESULTS: No significant changes in body @entity551 were observed. Serum albumin and prealbumin levels showed a significant increase. @entity14588 decreased significantly. DPI, energy intake, PINI, and MNA score did not change significantly. No @entity1 reported side effects or fluid retention during the study. CONCLUSION: Correction of @entity520 improves serum albumin and prealbumin concentration, and it is not associated with any significant change in DPI, but induces a decrease in @entity14588 values. Whereas @entity14588 may provide an index of protein catabolism, it does not differentiate between dietary sources of protein or net catabolism of endogenous proteins. In the absence of dietary changes, the decrease in @entity14588 values may be attributed to a decrease in whole body protein degradation.

title: Effect of the correction of @entity520 on nutritional status in elderly XXXX with @entity177 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure', 'CRF']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['MA', 'Metabolic acidosis']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['weight or systolic and diastolic blood pressure']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIMS: To investigate the effect of sequential treatment escalation with @entity18618 and @entity35742 on laboratory markers of a- and b-cell function in @entity1 with @entity6 ( @entity6 ) insufficiently controlled on @entity2449 monotherapy. RESEARCH DESIGN AND METHODS: A total of 44 @entity1 with @entity6 received 25   mg @entity18618 for a duration of 1   month in an open-label fashion (treatment period 1 [TP1]). Thereafter, they were randomized to a double-blind add-on therapy with @entity35742 5   mg or placebo (treatment @entity5394 [TP2]) for 1 additional month. a- and b-cell function was assessed using a standardized liquid meal test and an intravenous (i.v.) @entity413 challenge. Efficacy measures comprised the areas under the curve for @entity413 , insulin, @entity2690 and glucagon after the liquid meal test and the assessment of fast and late-phase insulin release after an i.v. @entity413 load with a subsequent hyperglycaemic clamp. RESULTS: @entity18618 reduced fasting and postprandial plasma @entity413 levels, associated with a significant reduction in postprandial insulin levels and an improvement in the conversion rate of @entity2690 (TP1). The addition of @entity35742 during TP2 further improved postprandial @entity413 levels, probably as a result of a marked reduction in postprandial glucagon concentrations (TP2). The insulin response to an i.v. @entity413 load increased during treatment with @entity18618 (TP1), and further improved after the addition of @entity35742 (TP2). CONCLUSION: After @entity2449 failure, sequential treatment escalation with @entity18618 and @entity35742 is an attractive treatment option because of the additive effects on postprandial @entity413 control, probably mediated by complementary effects on a- and b-cell function.

title: Effects on a- and b-cell function of sequentially adding XXXX and @entity35742 to therapy in @entity1 with type 2 @entity6 previously receiving @entity2449 : An exploratory mechanistic study.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['T2DM', 'type 2 diabetes mellitus']

entities_list: @entity18618 :: ('MESH:C570240', 'Chemical') :: ['Empagliflozin', 'empagliflozin']

entities_list: @entity35742 :: ('MESH:C568794', 'Chemical') :: ['linagliptin']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']

answer: @entity18618 :: (MESH:C570240,Chemical) :: ['empagliflozin']


abstract: BACKGROUND: @entity68022 is a rare spondylo(epi) @entity1610 characteristized by delayed skeletal maturation and a constellation of @entity154 . Although metaphyseal irregularities/cupping have been noted, neither renal @entity1391 wasting nor @entity11089 have previously been reported. OBJECTIVE: To evaluate @entity5886 and @entity11089 in @entity68022 . @entity1 : Two @entity1 with @entity68022 presenting with hypophoshpatemia by 3 years of age. METHODS: Routine biochemistries to assess @entity5886 and renal @entity1391 wasting; radiographs (rachitic changes) and DEXA scan ( @entity1555 ); @entity11648 levels, @entity15396 and @entity11648 gene analyses performed ( @entity1 1). RESULTS: Both @entity1 had @entity5886 , decreased TRP, and @entity11089 . Oral @entity3151 and @entity3873 improved metaphyseal mineralization, yet serum @entity1391 levels remained relatively low and renal @entity1391 wasting persisted. @entity15396 and @entity11648 gene analyses were negative, whereas serum @entity11648 levels were markedly elevated in @entity1 1. CONCLUSION: We now demonstrate an association between @entity68022 , @entity12146 , and @entity11648 elevation. Screening @entity3151 levels may thus uncover a potentially treatable component of this disease.

title: XXXX in @entity68022 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'PATIENTS', 'Patient', 'girls']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['dysplastic features']

entities_list: @entity1610 :: ('MESH:D010009', 'Disease') :: ['chondrodysplasia']

entities_list: @entity68022 :: ('MESH:C537122', 'Disease') :: ['Opsismodysplasia', 'opsismodysplasia']

entities_list: @entity3873 :: ('MESH:D002117', 'Chemical') :: ['calcitriol']

entities_list: @entity5886 :: ('MESH:D017674', 'Disease') :: ['hypophosphatemia']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

entities_list: @entity12146 :: ('MESH:D063730', 'Disease') :: ['hypophosphatemic rickets']

answer: @entity12146 :: (MESH:D063730,Disease) :: ['Hypophosphatemic rickets']


abstract: BACKGROUND: No standard second-line treatments are available for @entity157 @entity1 who fail sorafenib therapy. We assessed the safety and efficacy of metronomic capecitabine after first-line sorafenib failure. METHODS: Retrospective analysis of consecutive @entity157 @entity1 receiving metronomic capecitabine between January 2012 and November 2014. The primary end-point was safety, secondary end-point was efficacy, including time-to-progression and overall survival. RESULTS: Twenty-six @entity1 (80% @entity1 -Pugh A, 80% Barcelona Clinic @entity96 stage C) received metronomic capecitabine (500mg/ @entity5353 ). Median treatment duration was 3.2 months (range 0.6-31). Fourteen (53%) @entity1 experienced at least one adverse event. The most frequent drug-related adverse events were bilirubin elevation (23%), @entity1295 (15%), @entity417 (11%), lymphoedema (11%), and @entity8566 (7.6%). Treatment was interrupted in 19 (73%) for disease progression, in 4 (15%) for @entity1578 , and in 1 (3.8%) for adverse event. Disease control was achieved in 6 (23%) @entity1 . Median time-to-progression was 4 months (95% confidence interval 3.2-4.7). Median overall survival was 8 months (95% confidence interval 3.7-12.3). CONCLUSIONS: Metronomic capecitabine was well tolerated in @entity157 @entity1 who had been treated with sorafenib. Preliminary data show potential anti- @entity5 activity with long-lasting disease control in a subgroup of @entity1 that warrants further evaluation in a phase III study.

title: Metronomic capecitabine as second-line treatment in XXXX after sorafenib failure.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['Liver Cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver deterioration']

entities_list: @entity8566 :: ('MESH:D060831', 'Disease') :: ['hand-foot syndrome']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: PURPOSE: To report 3 cases of @entity5123 of the lacrimal gland with atypical features. METHODS: The medical records, radiographic imaging, operative reports, and @entity5 histopathology of 3 @entity1 with unusual presentations of @entity5123 of the lacrimal gland were reviewed. RESULTS: All 3 @entity1 were females ranging in age from 18 to 64 years. The first @entity1 presented with abrupt orbital inflammation mimicking @entity4550 . The second @entity1 presented with a @entity158 . The last @entity1 demonstrated @entity730 with bony erosion on orbital imaging. Orbitotomy was performed in all cases. Histopathologic evaluation of all specimens with light microscopy was consistent with @entity5123 of the lacrimal gland. CONCLUSIONS: @entity5123 is the most common @entity5 of the lacrimal gland. A higher degree of suspicion must be present to make the correct diagnosis in cases with atypical features. @entity5123 may present abruptly with orbital inflammation mimicking @entity4550 , as a @entity158 , or demonstrate @entity730 with bony erosion on orbital imaging. Complete surgical excision of the lesion within its pseudocapsule is recommended to prevent local recurrences and, although less likely, the possibility of malignant transformation.

title: Atypical presentations of XXXX of the lacrimal gland.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'epithelial tumor']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity4550 :: ('MESH:D054517', 'Disease') :: ['orbital cellulitis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful subcutaneous nodule']

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['Pleomorphic adenoma', 'pleomorphic adenoma']

answer: @entity5123 :: (MESH:D008949,Disease) :: ['pleomorphic adenoma']


abstract: @entity521 ( @entity521 ) is the most common extracranial solid @entity5 of childhood. In @entity1442 stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic @entity554 @entity11069 ( @entity19586 ) induces apoptosis in @entity521 and @entity320 cell lines. We reported an in vitro potentiation of @entity19586 effects on @entity320 cells when the drug is incorporated into GD2-targeted immunoliposomes (anti-GD2-SIL- @entity19586 ). We investigated the antitumor activity of anti-GD2-SIL- @entity19586 against @entity521 cells, both in vitro and in vivo. Anti-GD2-SIL showed specific, competitive binding to and uptake by, various @entity521 cell lines. In in vitro @entity137 studies, @entity521 cells, incubated with 30 microM @entity19586 entrapped in anti-GD2-immunoliposomes, showed a significant reduction in cellular growth compared to free @entity19586 , @entity19586 entrapped in Ab-free liposomes or anti-GD2 empty liposomes. In an in vivo @entity521 metastatic model, we demonstrated that anti-GD2-SIL- @entity19586 completely inhibited the development of macroscopic and microscopic @entity3 in comparison to controls. Similar, but significantly less potent, antitumor effect was observed also in @entity19 treated with anti-GD2 immunoliposomes without @entity19586 (anti-GD2-SIL-blank) or anti-GD2 MAb alone (p = 0.0297 and p = 0.0294, respectively, vs. anti-GD2-SIL- @entity19586 ). Moreover, our results clearly demonstrated that although anti-GD2 MAb had a strong antitumor effect in this in vivo @entity521 model, 100% curability was obtained only after treatment with anti-GD2-SIL- @entity19586 (p < 0.0001). Anti-GD2 liposomal @entity19586 should receive clinical evaluation as adjuvant therapy of @entity521 .

title: In vitro and in vivo antitumor activity of liposomal @entity11069 targeted to human XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity11069 :: ('MESH:D017313', 'Chemical') :: ['Fenretinide']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['NB', 'neuroblastoma', 'Neuroblastoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity554 :: ('CHEBI:26537', 'Chemical') :: ['retinoid']

answer: @entity521 :: (MESH:D009447,Disease) :: ['neuroblastoma']


abstract: PURPOSE: This study aimed to investigate the relationship between parental mental health, particularly @entity308 , and Internet @entity988 (IA) among adolescents. METHODS: This was a population-based parent-and- @entity1 dyad health survey utilising a random sampling technique. Adolescent IA was measured by the Internet @entity988 Test (IAT) designed by Young. The mental health status of the parents was assessed using the @entity308 , @entity148 , Stress Scale (DASS). Data were analysed using logistic regression modelling techniques with adjustment for potential confounding factors. RESULTS: A total of 1098 parent-and- @entity1 dyads were recruited and responded to the survey providing usable information. For IA, 263 (24.0%) students could be classified as at risk of moderate to severe IA. About 6% (n=68), 4% (n=43), and 8% (n=87) of parents were categorised to be at risk of moderate to severe @entity308 , @entity148 , and stress respectively. Regression analysis results suggested a significant association between parental @entity308 at the level of moderate to severe and IA in adolescents after adjusting for potential confounding factors (OR=3.03, 95% C.I.=1.67-5.48). On the other hand, no associations between parental @entity148 and stress and @entity1 's IA were observed. CONCLUSIONS: The result suggested that there was a significant relationship between parental mental health, particularly @entity308 , and the IA status of their @entity1 . These results have direct implications on the treatment and prevention of Internet @entity988 among young @entity1 .

title: Parental mental health and Internet XXXX in adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'people', 'child']

entities_list: @entity988 :: ('MESH:D000437', 'Disease') :: ['Addiction']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety']

answer: @entity988 :: (MESH:D000437,Disease) :: ['Addiction']


abstract: The typical presentation of @entity4053 involves a diaphoretic @entity1 with a history of @entity6 who is found with an altered mental status. The hypoglycemic @entity1 's presentation may lead the physician to believe that the altered mentation may have been caused by some other condition. @entity4053 occurs rarely in the traumatic setting, yet is easily and rapidly diagnosed with bedside testing. A retrospective review was conducted in a university hospital @entity341 ( @entity341 ) (level 1 @entity130 center) of adult @entity130 @entity1 with a Glasgow @entity772 Scale (GCS) score of <15 who had presented from July 1995 through August 1996. @entity4053 was defined as a serum @entity413 level of <60 mg/dL. A total of 926 @entity1 (49% of all @entity130 cases encountered in the period) met entry criteria. Four (0.4%) cases of @entity4053 were encountered in 1 nondiabetic and 3 @entity6 @entity1 ; no @entity1 had medical alert warnings. Rapid bedside screening identified 2 cases within a mean of 7 minutes after arrival; 1 @entity1 had an improvement in mental status after dextrose therapy. Two cases were identified by formal laboratory analysis a mean of 35 minutes after @entity341 arrival; @entity413 therapy improved the mental status in 1 @entity1 . These results show that @entity4053 , rare in @entity130 @entity1 with abnormal GCS scores, may mimic significant @entity130 with mental status alterations. Physicians should consider such a diagnosis in @entity1 with an abnormal GCS score and known risk situations for @entity4053 , including @entity6 and chronic @entity167 use; in such cases, appropriate bedside screening should be performed after initial stabilization.

title: @entity4053 in multiple XXXX victims.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes mellitus']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['Hypoglycemia', 'hypoglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'dextrose']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: @entity510 ( @entity510 ) can extend into the intracranial subarachnoid space, but, severe @entity2553 is rare complication of the extension of intracranial @entity510 from a spinal subarachnoid @entity1410 . A 67-year-old woman started anticoagulant therapy for unstable @entity951 . The next day, she developed @entity615 and @entity451 . MRI showed intradural and extramedullar low signal intensity at the T2-3, consistent with intradural @entity1410 . High signal intensity was also noted in the spinal cord from C5 to T4. We removed subarachnoid @entity1410 compressing the spinal cord. The following day, the @entity1 complained of severe @entity10 . Brain CT revealed @entity510 around both parietal lobes. Three days later, her consciousness decreased and left @entity1158 also developed. Brain MRI demonstrated multiple @entity385 , mainly in the right posterior cerebral artery territory, left parietal lobe and right watershed area. Conventional cerebral angiography confirmed diffuse severe @entity2553 of the cerebral arteries. After intensive care for a month, the @entity1 was transferred to the rehabilitation department. After 6 months, @entity16 improved partially. We speculate that surgeons should anticipate possible delayed @entity16 due to @entity2553 if intracranial @entity510 is detected after spinal subarachnoid @entity1410 .

title: Intracranial extension of spinal subarachnoid XXXX causing severe @entity2553 .

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['paraplegia']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['Spinal subarachnoid hemorrhages', 'SAH']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications', 'neurologic deterioration']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['severe back pain']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['cerebral vasospasm', 'vasospasm']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarctions']

answer: @entity1410 :: (MESH:D006406,Disease) :: ['hematoma']


abstract: BACKGROUND: The @entity29331 protein is an essential factor in regulating cell cycle by mediating the ubiquitination of CDK inhibitor @entity13524 ( @entity13525 ). It has been reported that aberrant expression of @entity29331 and @entity13524 ( @entity13525 ) proteins was found in various @entity5 and related to @entity189 . However, the potential roles which @entity29331 and @entity13524 ( @entity13525 ) proteins play in @entity11408 remain unclear. This study aims to examine the expression status of @entity29331 and @entity13524 ( @entity13525 ) and their possible prognostic significance in @entity11408 . METHODS: Paraffin-embedded specimens with @entity11408 (n   =   168) and non-tumor nasopharyngeal tissues (n   =   49) were analyzed by IHC. RESULTS: Expression of @entity29331 increased in @entity11408 tissues compared with non-tumor nasopharyngeal tissues (P   <   0.05), whereas @entity13524 ( @entity13525 ) protein frequently expressed in non-tumor nasopharyngeal tissues compared with @entity11408 tissues (P   <   0.05). There was a significant reverse correlation between @entity29331 and @entity13524 ( @entity13525 ) protein expression in @entity11408 (r   =   -0.189, P   <   0.05).In addition, Kaplan-Meier survival curve showed that there was a significant tendency of shorter overall survival (OS) in @entity11408 @entity1 with @entity29331 positive expression compared to negative ones, especially in @entity1 with lymph node @entity3 (P   <   0.001, respectively). But there was no significance between @entity13524 ( @entity13525 ) expression and survival viability of @entity11408 @entity1 . Multivariate Cox regression analysis further identified increased expression of @entity29331 was the independent poor prognostic factor for @entity11408 (p   =   0.13). CONCLUSION: Our research found expression of @entity29331 increased and was inverse to the expression of @entity13524 ( @entity13525 ). High expression of @entity29331 was significantly associated with lymph node @entity3 and survival status in @entity11408 . In addition, the abnormally high level of @entity29331 protein was proved to be an independent poor prognostic factor in @entity11408 . These results may provide novel clue for @entity11408 therapy method.

title: Increased expression of @entity29331 protein is associated with lymph node @entity3 and poor prognosis in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['initiation and progression of carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']


abstract: OBJECTIVE: To determine the efficacy of a short intravenous course of high-dose @entity1667 compared with the standard treatment with @entity229 for adult @entity1 with @entity3039 ( @entity3039 ). DESIGN: Retrospective. METHODS: For all @entity1 diagnosed with @entity3039 between January 1st 1988 and January 1st 1998 in the University Hospital Vrije Universiteit, Amsterdam, the Netherlands, data were obtained until June 1st 1998. These @entity1 had received a brief course of treatment with @entity1667 i.v. (1 g per day on three successive days in the outpatient department) or the standard treatment (protracted oral treatment with @entity229 ). A response was defined as a rise in platelet count of > 50 x 10(9)/l. When a remission lasted more than a year a @entity1 was defined as longterm responder. RESULTS: The results concerned 41 @entity1 . The @entity229 group comprised 7 males and 20 females, mean age 39 years, the @entity1667 group comprised 2 males and 12 females, mean age 43 years. Initial treatment with @entity229 or @entity1667 resulted in equal response rates of, respectively, 63% (17/27 @entity1 ) and 64% (9/14 @entity1 ). The number of longterm responders was 8 of 27 @entity1 in the @entity229 group and 2 of 14 @entity1 in the @entity1667 group. At time of relapse 22 @entity1 were treated with the other treatment modality. The response rate in the group of @entity1 treated with @entity229 after first-line treatment with @entity1667 , was 67% (6/9), for @entity1667 after first-line treatment with @entity229 the response rate was 23% (3/13). CONCLUSION: A short intravenous course of high-dose @entity1667 is effective as initial treatment of adults with @entity3039 . @entity137 of longterm treatment with @entity229 can be avoided in a number of @entity1 with @entity3039 . In @entity1 refractory to treatment with @entity1667 , the response rate to second-line treatment with @entity229 was not negatively influenced, since two thirds of these relapsing @entity1 subsequently responded to @entity229 .

title: [Intravenous high-dose @entity1667 efficacy for treatment of XXXX in adults].

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity3039 :: ('MESH:D016553', 'Disease') :: ['ITP', 'idiopathic thrombocytopenic purpura']

answer: @entity3039 :: (MESH:D016553,Disease) :: ['idiopathic thrombocytopenic purpura']


abstract: BACKGROUND: The practice of 1:1 transfusion, administering packed red blood cells (PRBCs) with fresh frozen plasma (FFP), has been associated with improved survival. However, the reported ratios are the result of mathematical averages over 24 hours and do not necessarily represent concurrent administration. Using critical administration thresholds (CAT+) of more than 3 U of PRBC per hour to identify @entity548 @entity1 , this study evaluates the effect of concurrent administration of PRBC/FFP on @entity1 survival. METHODS: CAT+ @entity1 identified retrospectively were eligible for analysis. The exact time of administration of each unit of PRBC and FFP was calculated. Each PRBC was matched to a corresponding unit of FFP given within 5 minutes before or after. Ideal 1:1 ratios were calculated for each hour during the first day of admission. Hourly ratio groups were created (25%, 50%, 75% of transfusion opportunities) and evaluated as time-varying covariates. Cox proportional hazard ratio (HR) was used to determine risk of mortality, and Student's t test or Wilcoxon signed-rank test was used to compare groups. RESULTS: A total of 169 @entity1 were initially identified (70% with New Injury Severity Score [NISS] > 10), 77 of whom were CAT+. There were no clinical differences between the groups in this study. In terms of mortality, @entity1 who reached the 1:1 ratio 25% of the transfusion opportunities had an HR of 8.806 (95% confidence interval [CI], 1.845-42.034). @entity1 meeting the 1:1 ratio 50% of the opportunities had an HR of 5.062 (95% CI, 1.115-22.982) while those meeting 75% of the opportunities had an HR of 1.888 (95% CI, 0.198-18.035). CONCLUSION: CAT+ @entity1 represent the @entity130 subset at highest risk of mortality and may benefit from a focused blood-based resuscitation. @entity1 who were able to meet the 1:1 ratio more often had a noticeable decrease in risk of @entity204 compared with those who achieved less than 1:1 transfusions. Administering FFP concurrently with PRBC is associated with a decrease in mortality in CAT+ @entity1 . LEVEL OF EVIDENCE: Prognostic, level III.

title: Time matters in 1: 1 resuscitations: Concurrent administration of blood: plasma and risk of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhaging']

answer: @entity204 :: (MESH:D003643,Disease) :: ['death']


abstract: AIM: The renal @entity3449 -angiotensin system (RAS) has been implicated in the pathogenesis of @entity2316 . The aim of this study was to investigate sex differences in renal @entity3449 -angiotensin system (RAS) and the roles of androgens in @entity6 -associated @entity8 . METHODS: @entity8 and @entity82 were studied in streptozotocin-induced @entity6 @entity35 by @entity633 and by gene expression of collagen I and fibronectin. RAS was investigated by analysing the plasma angiotensinogen (AOGEN) and @entity3449 activity (PRA) and their renal gene expression. Also, a group of @entity6 @entity35 was treated with the anti-androgen flutamide. RESULTS: @entity633 was significantly lower in @entity6 females than in males (1.2 [0.8-1.5] versus 4.4 [2.2-6.1] mg/24  h, data are median [IQR] values, P  <  0.05). Renal AOGEN mRNA levels were increased by @entity6 in males (8.1      0.8% in @entity6 versus 0.8      0.2% in control, P  <  0.001) but not in females (1.0      0.1% in @entity6 versus 0.8      0.1% in control, P  >  0.05), as were collagen I and fibronectin mRNAs. Furthermore, AOGEN mRNA levels were strongly correlated with @entity633 (Spearman r  =  0.64, 95% [CI] 0.36-0.81, P  <  0.0001). @entity6 decreased PRA, renal @entity3449 mRNA and plasma AOGEN in both females and males. Anti-androgen treatment decreased @entity633 only in @entity6 without affecting the endocrine or renal RAS. CONCLUSIONS: These data indicate that renal but not hepatic AOGEN or @entity3449 is positively associated with @entity6 @entity633 and contribute to the sex-dependent differences in @entity8 . Androgens may contribute to @entity633 in male independently of the RAS.

title: Sex-dependent differences in renal angiotensinogen as an early marker of XXXX .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal injury', 'renal injury']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic males', 'diabetic', 'diabetes']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria', 'Albuminuria']

answer: @entity2316 :: (MESH:D003928,Disease) :: ['diabetic nephropathy']


abstract: BACKGROUND: Molecular techniques for @entity1082 ) detection have a good performance as screening tests and could be included in @entity5 early detection programs. We conducted a population-based trial comparing HPV detection and Papanicolaou as primary screening tests, in a public health service in Santiago, Chile. AIM: To describe the experience of implementing this new molecular test and present the main results of the study. MATERIAL AND METHODS: @entity1 aged 25 to 64 enrolled in three public health centers were invited to participate. In all @entity1 , samples were collected for Papanicolaou and HPV DNA testing, and @entity227 with @entity1543 was performed. @entity1 with any positive screening test were referred to the local area hospital for diagnostic confirmation with colposcopy and biopsy of suspicious lesions. RESULTS: Screening results were obtained for 8265 @entity1 , of whom 931 (11.3%) were positive to any test. The prevalence of @entity3146 or worse (CIN2+) was 1.1%; nine @entity1 had @entity3 . Sensitivities for the detection of CIN2+ were 22.1% (95% confidence interval (CI) 16.4-29.2) for Papanicolaou and 92.7% (95% CI 84.4-96.8) for HPV testing; specificities were 98.9% (95% CI 98.7-99.0) and 92.0% (95% CI 91.4-92.6) respectively. CONCLUSION: This experience showed that the implementation of a molecular test for @entity5 screening is not a major challenge in Chile: it was well accepted by both the health team and the @entity1 , and it may improve the effectiveness of the screening program.

title: [ @entity1082 testing in XXXX screening at a public health service of Santiago, Chile].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['naked-eye visual inspection of the cervix']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cervical cancer']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

entities_list: @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia grade 2']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']


abstract: PURPOSE: To evaluate the rates of @entity177 ( @entity177 ) vs @entity3 ( @entity3 ), and find risk factors for recurrence in @entity1 with completely resected N1 @entity1149 ( @entity1149 ). METHODS: By searching Pubmed, Embase and the Cochrane Controlled Trials Register from 1995 through 2014, eligible randomized clinical trials (RCTs) were identified. In addition, the reference lists of articles and conference abstracts were searched. The logarithm of the risk ratio (RR) and its @entity2246 ( @entity2246 ) were calculated, and a fixed-effect model was used to combine the estimates. RESULTS: 3 RCTs and 9 retrospective studies, which included 889 @entity1 , were identified and selected. All studies dealt with resected N1 @entity1149 , @entity177 , and risk factors such as visceral pleural invasion (VPI) and lymphovascular invasion (LVI). There was statistically significant benefit on 5-year overall survival (OS) for @entity177 (RR=0.68,95% CI=0.60-0.78, p<0.00001). Further analysis for @entity1 with @entity177 also showed that VPI (RR=1.25, 95% confidence interval/CI=1.09-1.42, p=0.0009), LVI (RR=1.16, 95% CI=1.04-1.30, p=0.009), were the main risk factors for recurrence. CONCLUSIONS: The present study indicates that in @entity1 with resected N1 @entity1149 , the incidence of @entity177 is lower than @entity3 . @entity1442 stage classification, VPI, and LVI were predictors of poor survival. These @entity1 represent a subgroup with N1 disease who might benefit from additional therapy, including adjuvant radiotherapy (RT). However, large, well-designed prospective studies should be conducted to confirm this conclusion.

title: Risk factors for recurrence in XXXX with resected N1 @entity1149 - a systematic review and meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['LRF vs DM', 'locoregional failure', 'LRF']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['Advanced T']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['DM', 'distant metastasis']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['standard error', 'SE']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Research on @entity8434 ( @entity8434 ) has a long history in Kenya, but has mainly concentrated on two discrete areas, Turkana and Maasailand, which are known to be foci of @entity1 @entity8434 in Africa. Here, we report on a survey for @entity8434 in livestock from central to northeastern Kenya, from where no previous data are available. A total of 7,831 livestock carcasses were surveyed. @entity8434 prevalence was 1.92% in @entity291 (n   =   4,595), 6.94% in @entity20770 (n   =   216), 0.37% in @entity1237 (n   =   2,955) and 4.62% in @entity742 (n   =   65). Identification of the parasite was done using an RFLP-PCR of the mitochondrial nad1 gene, which had been validated before against the various @entity36036 taxa currently recognized as distinct species. From a total of 284 recovered cysts, 258 could be identified as @entity12047 sensu stricto (n   =   160), @entity45047 (n   =   51) and @entity36036 (n   =   47) by RFLP-PCR of nad1. In @entity291 , fertile cysts occurred mostly in the lungs and belonged to @entity45047 (31 of 54), while the vast majority were sterile or @entity6538 of @entity12047 .. Most fertile cysts in @entity20770 belonged to @entity36036 (33 of 37); sterile or @entity6538 were rare. @entity1237 harboured fertile cysts of @entity45047 (n   =   3)--which is the first record in that host species--and @entity36036 (n   =   1), while all cysts of @entity12047 were sterile. Only sterile cysts were found in the three examined @entity742 . Typically, all cysts in animals with @entity281 belonged to the same species, while mixed @entity281 were rare. Our data indicate that the epidemiological situation in central to northeastern Kenya is clearly different from the well-studied pastoral regions of Turkana and Maasailand, and the apparently low number of @entity1 @entity8434 cases correlates with the infrequent occurrence of @entity12047 .

title: XXXX spp. in central Kenya: a different story.

entities_list: @entity36036 :: ('519352', 'Species') :: ['Echinococcus', 'E. canadensis']

entities_list: @entity8434 :: ('MESH:D004443', 'Disease') :: ['CE', 'cystic echinococcosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['multiple infections', 'infections']

entities_list: @entity12047 :: ('6210', 'Species') :: ['E. granulosus', 'E. granulosus s.s', 'Echinococcus granulosus']

entities_list: @entity6538 :: ('MESH:D018333', 'Disease') :: ['calcified cysts']

answer: @entity36036 :: (519352,Species) :: ['Echinococcus']


abstract: The involvement of @entity7242 , @entity5605 , @entity3547 and @entity6164 in the regulation of podosome assembly has been identified in various cell models. In endothelial cells, the ectopic expression of constitutively active mutants of @entity7242 or @entity5605 , but not @entity3547 , induced the formation of podosomes. Short-term exposure to @entity1359 ( @entity4515 ) induced the appearance of podosomes and rosettes after initial disruption of stress fibres. Molecular analysis of @entity4515 -induced podosomes and rosettes revealed that their composition was identical to that of podosomes described in other models. Pharmacological inhibition and siRNA knock-down experiments revealed that both @entity10185 and @entity4456 isotypes were necessary for podosome assembly. However, only constitutively active @entity10185 could mimic @entity4515 in podosome formation. @entity7242 , @entity5605 and @entity3547 were required downstream of PKCs in this process. @entity7242 could be positioned between @entity6164 and @entity5605 in a linear cascade leading to podosome assembly. Using in vitro matrix degradation assays, we demonstrated that @entity4515 -induced podosomes are endowed with proteolytic activities involving @entity1551 -mediated activation of @entity1476 . Endothelial podosomes may be involved in subendothelial matrix degradation during endothelium remodelling in pathophysiological processes.

title: A signalling cascade involving @entity6164 , XXXX and @entity5605 regulates podosome assembly in cultured endothelial cells in response to phorbol ester.

entities_list: @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol-12-myristate-13-acetate']

answer: @entity7242 :: (6714,Gene) :: ['Src']


abstract: PURPOSE: In order to confirm the efficacy, tolerability, and baseline prognostic factors of an @entity1259 (EPR)-containing triplet regimen, the EOF5 regimen, in @entity1 with @entity356 ( @entity356 ), we conducted the phase II trial and retrospective analysis. METHODS: @entity356 @entity1 received the EOF5 regimen (EPR 50  mg/m(2) and @entity901 (OX) 130  mg/m(2) on day 1 followed by continuous infusion of @entity1487 ( @entity1487 ) 375-425  mg/m(2)/days for 5  days every 3  weeks). Log-rank tests were used for univariate analysis of @entity1054 ( @entity1054 ) and @entity1168 ( @entity1168 ), and stepwise Cox proportional hazards regression modeling was performed to generate a prognostic index. RESULTS: A total of 158 @entity1 received the EOF5 regimen. Of the 150 evaluable @entity1 , complete remission, partial remission, and stable disease were observed in 5 (3.3  %), 70 (46.7  %), and 58 @entity1 (38.7  %), respectively. The median @entity1054 and @entity1168 were 6.0 (95  % CI 5.4-6.6) and 12.6  months (95  % CI 8.2-16.9), respectively. Grade 3-4 @entity1398 (44.0  %), @entity882 (25.3  %), and @entity417 (6.7  %) were recorded. A prognostic index that included liver and lung metastasis, ascites/ @entity1143 , and baseline serum CA19-9 was used to categorize the @entity1 into three groups: good risk (0 risk factors), moderate risk (1 or 2 risk factors), and poor risk (3 or 4 risk factors). The median @entity1168 for these groups was 30.4, 12.4, and 5.6  months, respectively (P  <  0.001). CONCLUSIONS: EOF5 is an effective regimen and a suitable alternative for the first-line treatment of @entity356 . According to the prognostic index used in our study, @entity1 with no risk factors have a better @entity1168 when treated with EOF5 than those with one or more risk factors.

title: XXXX combined with @entity901 and 5-day continuous infusion of @entity1487 as a first-line treatment for @entity356 : treatment outcomes and analysis of prognostic factors.

entities_list: @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['OS', 'overall survival rate']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['TTP', 'time to progression']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['MGC', 'metastatic gastric cancer']

answer: @entity1259 :: (MESH:D015251,Chemical) :: ['Epirubicin']


abstract: OBJECT: Determining the influence of three weekly strength training (ST) sessions, over a ten-week period, on @entity432 ( @entity432 ) and taking the associated anthropometric measurements. METHODS: This was a before-and-after intervention trial, involving a sample of 17 individuals. @entity1 were adults from both genders aged 18 and 40 years-old who had been sedentary for at least three months previously. Anthropometric measurements were taken, together with pulse wave velocity ( @entity122 ) before and immediately after the experimental sessions. RESULTS: Independent variables (age and gender) were considered for determining their influence on final @entity122 and anthropometric measurements. Comparing initial @entity122 (mean=9.00) with final @entity122 (mean=9.00) for subjects involved in the proposed ST revealed no significant difference between them (p=0.469). Regarding anthropometric measurement, individuals' body fat (p<0.001) and body fat mass percentages (p<0.001) became significantly reduced, accompanied by an increase in lean mass (p<0.001). However, no changes were recorded regarding waist-to-hip ratio (WHR) (p= 0.777), body mass (p=0.226) or body mass index (BMI) (p =0.212). CONCLUSION: This study's findings suggested that the proposed ST did not increase @entity432 . Devotees of such type of training may therefore safely enjoy all its benefits without risk to the cardiovascular system. Further controlled and randomized research is needed to confirm these results.

title: [Muscular strength training does not increase @entity1 adults' XXXX or improve body toning].

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial stiffness', 'AS']

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

answer: @entity432 :: (MESH:D001157,Disease) :: ['arterial stiffness']


abstract: UNASSIGNED: Patterns of genetic variation and @entity74 ( @entity74 ) were investigated in Crossocalyx hellerianus, a strictly epixylic dioicous @entity42721 (Scapaniaceae s.l., Marchantiophyta). Studied populations were located in Fennoscandia and Central Europe, with localities differing in availability of substrate and the population connectivity, and their populations consequently different in size, density, and prevailing reproductive mode. A set of nine polymorphic microsatellites was successfully developed and used. Identical individuals were only found within populations. Especially in large populations, the majority of the individuals were genetically unique. Resampled number of genotypes, mean number of observed alleles per locus after rarefaction, and Nei's gene diversity in large populations reached high values and ranged between 4.41-4.97, 3.13-4.45, and 0.94-0.99, respectively. On the contrary, the values in small populations were lower and ranged between 1.00-4.42, 1.00-2.73, and 0.00-0.95, respectively. As expected, large populations were found to be more genetically diverse than small populations but relatively big diversity of genotypes was also found in small populations. This indicated that even small populations are important sources of genetic variation in bryophytes and processes causing loss of genetic variation might be compensated by other sources of variability, of which somatic mutations might play an important role. The presence of @entity74 was discovered in all populations. Large populations possessed less @entity74 , with individuals showing a pronounced decrease in kinship over 50 cm of distance. Apparent @entity74 of small populations even at distances up to 16 meters suggests the aggregation of similar genotypes, caused predominantly by the deposition of asexually formed gemmae. Although no strong kinship was detectable at the distances over 16 meters in both small and large populations, identical genotypes were occasionally detected at longer distances (20-80 m), suggesting effective dispersal of asexual propagules.

title: Comparison of Genetic Structure of Epixylic XXXX Crossocalyx hellerianus between Central European and Fennoscandian Populations.

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['SGS', 'spatial genetic structure']

answer: @entity42721 :: (3197,Species) :: ['Liverwort']


abstract: PURPOSE: To evaluate the incidence, cause, and management of delivery system occlusions during yttrium-90 ((90)Y) microsphere infusions and to identify techniques to prevent occlusions. MATERIALS AND METHODS: A retrospective review was conducted of 885 consecutive radioembolization deliveries during 820 procedures (some with multiple deliveries) in 503 @entity1 (mean age, 65 y; 293 male) performed between June 2001 and July 2013 at a single academic tertiary care hospital. @entity432 were reported prospectively, and procedural details were reviewed. Statistical analysis assessed associations between catheter occlusions and @entity1 and procedural characteristics. RESULTS: Of 885 (90)Y microsphere deliveries, 11 resulted in occlusion (1.2%). Five occlusions were associated with contained leakage of radioactive material, and one was associated with a spill. Treatment was completed in the same day in 10 @entity1 ; repeat catheterization was required in five @entity1 . One @entity1 returned 1 week later to complete treatment. @entity432 were more frequent with deliveries of resin (11/492; 2.2%) versus glass (0/393; 0%) microspheres (P = .002). @entity432 were more likely to occur within the proximal portion of the delivery apparatus (P = .002). There was no significant relationship with any @entity1 characteristics, and there was no improvement with operator experience. The most common cause of occlusion was resin microsphere delivery device failure. CONCLUSIONS: (90)Y microsphere delivery device occlusion is uncommon but does occur with resin microspheres. Understanding causes and how to troubleshoot can limit the incidence and detrimental effects.

title: Yttrium-90 Infusion: Incidence and Outcome of XXXX during 885 Deliveries.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['Occlusions']

answer: @entity432 :: (MESH:D001157,Disease) :: ['Delivery System Occlusions']


abstract: BACKGROUND: @entity3145 ( @entity3145 ) have recently emerged as powerful tools to rapidly analyze the clinical significance of new molecular markers in @entity1 @entity5 . Here, we have tested several molecular markers on a prostate @entity3145 containing 637 different specimens. METHODS: The specimens were from 551 @entity1 with @entity263 and long-term follow-up information on progression (median 5.3 years), @entity5 -specific and overall survival (median 5.9 years). Eighty-six specimens from @entity1067 were included as controls. Expression of Ki67, @entity588 , @entity876 , @entity2282 (neutral endopeptidase), and @entity13221 ( @entity13221 ) was analyzed by immunohistochemistry. RESULTS: Gleason grade and Ki67 @entity894 ( @entity894 ) were independent predictors of early recurrence and poor survival. @entity588 predicted early recurrence, whereas @entity876 was associated with poor survival. @entity13221 overexpression also predicted early recurrence and was significantly associated with @entity5 specific survival, high Gleason grade, Ki67 @entity894 , and @entity588 overexpression. Neoadjuvant hormonal therapy was associated with overexpression of @entity588 and inhibition of Ki67 @entity894 and @entity2282 , but did not affect the expression of the remaining markers. CONCLUSIONS: The results of this @entity3145 study confirm a dominant prognostic significance of Gleason grading and Ki67 @entity894 in @entity263 , as compared to a less pronounced role of @entity588 , and @entity876 . We identified @entity13221 as a new prognostic factor and provide evidence for an @entity342 -dependent regulation of @entity2282 expression.

title: Tissue microarray analysis reveals prognostic significance of @entity13221 expression in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity894 :: ('MESH:C566784', 'Disease') :: ['Labeling Index', 'LI']

entities_list: @entity3145 :: ('MESH:D017695', 'Disease') :: ['Tissue microarrays', 'TMA']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: The disease natural history of @entity14 regarding two opposing theories, @entity2513 sequence and de novo @entity189 theory, is controversial and rarely quantified. The aims of this study are therefore to estimate the dwelling times of @entity2513 sequence by @entity652 size and histological type, taking de novo @entity189 into account. The efficacy of polypectomy was therefore estimated making allowance for two pathways. A case-cohort design, underpinning a cohort with 13 908 subjects (including 10 496 normal subjects, 2652 @entity1127 , 760 @entity14 ) who underwent the first examination of colonoscopy between 1979 and 1998, was devised to estimate parameters associated with two opposing theories by randomly selecting 305 normal subjects, 300 @entity1 with @entity1127 , and 116 @entity14 from the cohort. All the 2652 @entity1127 were linked to national @entity5 registry to ascertain 25 invasive @entity189 after polypectomy. For the five-state model associated with @entity652 size, dwelling times of small (0.6-1 cm) and large @entity652 (>1 cm) are 7.75 and 5.27 years for the model without considering de novo, and 17.48 and 15.90 years for the model taking de novo @entity189 into account. Similar findings are observed for the model associated with histological type. The estimated proportions of de novo @entity189 are 31.87% from the model by @entity652 size and 27.81% from the model by histological type. Compared to size less than 5 mm, @entity1 with @entity652 size between 6 and 10 mm and @entity1 with @entity652 size larger than 1 cm have 2.17-fold (0.67-10.74) and 4.25-fold (1.23-14.70), respectively, for the risk of malignant transformation. There are similar findings for the model by histological type. The estimates of overall efficacy of colonoscopy in reducing CRC is 73% for the model allowing for de novo @entity189 and 88% for the model without considering de novo @entity189 theory. The efficacy of diminutive @entity652 and small @entity652 increases with follow-up years, whereas the efficacy of large @entity652 decreases with follow-up years. In conclusion, about 30% of @entity5 arising from de novo sequence are demonstrated. This finding, together with the @entity2513 sequence associated with @entity652 size and histological type, is important for the estimation of dwelling times, the efficacy of colonoscopy, and the surveillance of polyp after polypectomy.

title: A case-cohort study for the disease natural history of @entity2513 and de novo XXXX and surveillance of colon and rectum after polypectomy: implication for efficacy of colonoscopy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal neoplasm']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma-carcinoma']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinoma']


abstract: Ninety-six @entity1 with @entity14 (stage B2-C) were randomized to the control arm or to receive adjuvant chemotherapy with @entity4181 , FU and @entity1139 . Ninety-three @entity1 are evaluable. The median follow up is 12 months. The average time between surgery and the start of therapy is 28 days. @entity137 is evaluable in 36 of 41 treated @entity1 . Four @entity1 (10%) failed to complete the projected treatment due to @entity137 . @entity137 observed in 208 courses of therapy was mostly gastrointestinal and hematological. No cases of treatment related @entity204 or @entity5 -associated @entity1381 (C-HUS) were reported. The average relative dose intensity (rDI) of the projected treatment was 82.6%. Our study is ongoing and further @entity1 are required to achieve statistically significant results.

title: 5-Fluorouracil (FU) with @entity4181 (FA) and mitomycin C ( @entity1139 ) in the adjuvant treatment of @entity14 . Part I. Evaluation of XXXX .

entities_list: @entity4181 :: ('MESH:D002955', 'Chemical') :: ['folinic acid']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: UNASSIGNED: There is increasing concern about the cardiovascular effects of @entity349 ( @entity5332 ) exposure, and that organic @entity5165 and inorganic @entity10694 may affect the cardiovascular system and blood pressure differentially. In small-scale gold mining communities where inorganic, elemental @entity5332 exposures are high, little is known about the effects of @entity5332 on blood pressure. In 2011, we assessed the relationship between @entity5332 exposure and blood pressure (BP) in a cross-sectional study of adults from a small-scale gold mining community, Kejetia, and subsistence farming community, Gorogo, in Ghana's Upper East Region. @entity1 ' resting heart rate and BP were measured, and hair and urine samples were provided to serve as biomarkers of organic and inorganic @entity5332 exposure, respectively. @entity1 included 70 miners and 26 non-miners from Kejetia and 75 non-miners from Gorogo. Total specific gravity-adjusted urinary and hair @entity5332 was higher among Kejetia miners than Kejetia non-miners and Gorogo @entity1 (median urinary @entity5332 : 5.17, 1.18, and 0.154   g/L, respectively; hair @entity5332 : 0.945, 0.419, and 0.181   g/g, respectively). @entity101 was prevalent in 17.7% of Kejetia and 21.3% of Gorogo @entity1 . Urinary and hair @entity5332 were not significantly associated with systolic or diastolic BP for Kejetia or Gorogo @entity1 while adjusting for sex, age, and smoking status. Although our results follow trends seen in other studies, the associations were not of statistical significance. Given the unique study population and high exposures to inorganic @entity5332 , the work contained here will help increase our understanding of the cardiovascular effects of @entity5332 .

title: An Investigation of Organic and Inorganic XXXX Exposure and Blood Pressure in a Small-Scale Gold Mining Community in Ghana.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

entities_list: @entity5165 :: ('CHEBI:30785', 'Chemical') :: ['methylmercury']

answer: @entity349 :: (MESH:D008628,Chemical) :: ['Mercury']


abstract: BACKGROUND: The purpose of this study was to analyze our experience of bypass procedures to an isolated ("blind") popliteal artery segment ( @entity19249 ) to revascularize the perigeniculate arteries in @entity1 with @entity63 ( @entity63 ), to establish whether such revascularizations could yield acceptable results in terms of patency and @entity4218 ( @entity4218 ) rates. METHODS: Over a decade, 347 above-knee arterial revascularizations were performed in 293 @entity1 and in 51 (14.7%) of these the outflow vessels were the perigeniculate arteries arising from an @entity19249 , through a reversed saphenous vein or spliced veins (n = 30, 58.8%; group I) or @entity736 (n = 21, 41.2%; group II) prosthetic grafts. Patency, @entity4218 , and survival rates were assessed using Kaplan-Meier life-table analysis. A complete follow-up (range, 0.1-10.4 years; mean, 5.6 years) was obtained in 49 @entity1 . RESULTS: The @entity19249 was chosen as the last resort in 39 @entity1 (76.5%) because no other infrapopliteal artery was identified as being available at angiography; in 12 @entity1 (23.5%) it was chosen because of an invasive @entity281 or @entity39 overlying the dorsalis pedis or the posterior tibial arteries. The study series was mainly male, with significantly more younger @entity1 in group I (72 +/- 1 years vs 74 +/- 5 years, P = .037). Group I had a statistically higher incidence of @entity6 (76.6% vs 47.6%, P = .033), insulin @entity734 (56.7% vs 28.6%, P = .047) and history of smoking (80% vs 47.6%, P = .016) than group II. None of the @entity1 died in the perioperative period. There were 3 early graft failures (2 in group I), prompting 3 major amputations. Kaplan-Meier analysis identified 5-year patency and @entity4218 rates of 51.4 +/- 9.6% and 90 +/- 4.3%, respectively, in the series as a whole, and the 2 groups had comparable 5-year patency, @entity4218 and survival rates. CONCLUSION: Revascularizations to an @entity19249 can be performed with acceptable results in terms of patency and @entity4218 rates, even when there is no infrapopliteal runoff vessel. Finding perigeniculate arteries arising from an @entity19249 with no tibio-peroneal vessel reconstitution at arteriography does not justify a pessimistic attitude to the performance of such revascularizations for @entity4218 .

title: Revascularization to an isolated ("blind") popliteal artery segment: a viable procedure for XXXX .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia', 'CLI']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['ischemic necrosis']

entities_list: @entity4218 :: ('MESH:D017880', 'Disease') :: ['limb salvage', 'LS']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['foot infection']

entities_list: @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence']

answer: @entity63 :: (MESH:D007511,Disease) :: ['critical limb ischemia']


abstract: OBJECTIVES/HYPOTHESIS: A persistent insufficiency of glottal closure is mostly a consequence of a unilateral vocal fold @entity717 . It can also be caused by vocal fold @entity194 or scarring processes with regular bilateral respiratory vocal fold function. Because of consequential voice, breathing, and @entity73 , a functional surgical treatment is required. The goal of the study was to outline the functional results after medialization thyroplasty with the @entity702 vocal fold medialization implant according to Friedrich. METHODS: In the period of 1999 to 2001, an external vocal fold medialization using the @entity702 implant was performed on 28 @entity1 (12 @entity1 and 16 @entity1 ). The @entity1 were in the age range of 19 to 84 years. Twenty-two @entity1 had a paralysis of the left-side vocal fold, and six @entity1 , of the right-side vocal fold. Detailed functional examinations were executed on all @entity1 before and after the surgery: perceptive voice sound analysis according to the "roughness, breathiness, and hoarseness" method, judgment of the s/z ratio and @entity409 index, voice range profile measurements, videostroboscopy, and pulmonary function tests. In case of @entity1282 / @entity1173 , videofluoroscopy of swallowing was also performed. The respective data were statistically analyzed (paired t test, Wilcoxon-test). RESULTS: All @entity1 reported on improvement of voice, swallowing, and breathing functions postoperatively. Videostroboscopy revealed an almost complete glottal closure after surgery in all of the @entity1 . All voice-related parameters showed a significant improvement. An increase of the laryngeal resistance by the medialization procedure could be excluded by analysis of the pulmonary function test. CONCLUSIONS: The results confirm the external medialization of the vocal folds as an adequate method in the therapy of voice, swallowing, and @entity73 attributable to an insufficient glottal closure. The @entity702 implant offers, apart from good tissue tolerability, the advantage of an easy, time-saving, and individually adjustable application during the operation.

title: Functional results after external vocal fold medialization thyroplasty with the XXXX vocal fold medialization implant.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['breathing impairment', 'swallowing impairments']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['voice dysfunction']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['movement impairment']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: OBJECTIVE: The objective of this study was to determine the efficacy and sensitivity of laparoscopic photodynamic diagnosis to detect @entity2518 (ALA)-induced @entity5 in an animal model. METHODS: @entity5 cells were injected into the peritoneum of @entity35 to induce @entity298 . After 3-4 weeks, ALA was administered to establish fluorescence in tumor nodules. All intraperitoneal surfaces were inspected using fluorescence and white light laparoscopy. @entity75 were then biopsied in vivo under either fluorescence or white light laparoscopic guidance. Fluorescence intensities of the @entity5 compared to normal tissues were determined. A pathologist blinded to our clinical impression analyzed all biopsied specimens. We compared the sensitivity of fluorescence and white light laparoscopic-guided detection of @entity5 and determined the clinical utility of fluorescent photodynamic diagnosis in detecting metastatic @entity43 . RESULTS: Forty-three biopsies were performed in vivo under laparoscopic fluorescent guidance and 42 biopsies were taken using white light in various regions of the peritoneal surface from nine @entity35 . Ten biopsies were also removed from nonfluorescent regions as nontumor controls. @entity5 showed significantly higher fluorescent intensity compared to noncancerous lesions. @entity5 that were difficult to differentiate from normal surrounding tissue under white light conditions were clearly detected by ALA-induced fluorescence. The average size of these metastatic lesions biopsied under fluorescent light was 1.0 mm (range: 0.3-2.5) compared to 1.5 mm (range: 0.5-2.9) with white light illumination (P < 0.05). CONCLUSIONS: Fluorescent laparoscopic detection of micrometastatic @entity43 using ALA is significantly more sensitive than white-light laparoscopy in detecting smaller @entity5 in an @entity43 @entity35 model. @entity1 trials are indicated.

title: Laparoscopic photodynamic diagnosis of XXXX using @entity2518 in a @entity35 model.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancerous lesions', 'fluorescent tumors', 'Cancerous lesions', 'Cancer']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Suspicious lesions']

entities_list: @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-aminolevulinic acid']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: UNASSIGNED: Essentials Low-molecular-weight heparin (LMWH) injections for @entity1211 ( @entity1211 ) may be burdensome. @entity1 with active @entity5 and confirmed @entity1211 were included to evaluate LMWH continuation. The cumulative incidence of discontinuation was 21% after a median period of 90 days. One out of five @entity1 discontinued LMWH injections because of side effects. SUMMARY: Background Current guidelines recommend low-molecular-weight heparin (LMWH) monotherapy for 3-6 months as the first-line treatment for @entity1211 ( @entity1211 ). However, although daily administration of LMWH injections over a course of several months may be burdensome, the number of @entity1 who stop treatment because of LMWH side-effects is unknown. Objectives To evaluate the continuation rate and complications of daily LMWH injections in @entity1 with @entity5 -associated @entity1211 . Methods Consecutive @entity1 with active @entity5 and objectively confirmed symptomatic proximal @entity6650 , treated at three Dutch hospitals and one Spanish hospital, were included to evaluate continuation LMWH therapy during LMWH treatment. @entity1 were excluded when they received other anticoagulants, were lost to follow-up, or experienced a venous catheter-associated @entity715 . Results A total of 372 @entity1 were analyzed during LMWH treatment for a maximum of 180 days. The cumulative incidence of discontinuation was 21% (95% confidence interval [CI] 17-25) after a median period of 90 days (interquartile range 60-120 days). Only female sex was found to be significantly associated with premature LMWH discontinuation (odds ratio 1.6; 95% CI 1.03-2.5). Thirty @entity1 (8.1%) developed recurrent @entity1211 , 30 @entity1 (8.3%) suffered a @entity548 , and 106 @entity1 (28%) died. Conclusion Our study reveals that one of five @entity1 with @entity5 -associated @entity1211 stopped LMWH injections because of side-effects. This finding provides relevant background information for current clinical trials investigating the efficacy and safety of direct oral anticoagulants as compared with LMWH.

title: Continuation of low-molecular-weight heparin treatment for XXXX : a prospective cohort study in daily clinical practice.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['major bleed']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity6650 :: ('MESH:D016769', 'Disease') :: ['deep vein thrombosis and/or pulmonary embolism']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['cancer-associated venous thromboembolism', 'VTE', 'venous thromboembolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1211 :: (MESH:D054556,Disease) :: ['cancer-related venous thromboembolism']


abstract: OBJECTIVE: The objective of this study was to investigate the long-term effect of intraoperative application of @entity134 suspension and coating of the electrode contacts with a thin film of @entity27213 on the intracochlear impedance development after cochlear implantation and on the impedance difference before and after stimulation. DESIGN: Time-dependent development of intracochlear impedances was investigated in 4 different groups of adult @entity1 up to 4 years after implantation. Additionally, during rehabilitation period just after first fitting, impedances before and after stimulation were measured as to investigate the influence of electrical stimulation on the impedances. Results from standard Nucleus 24 Contour (control), standard Nucleus 24 Contour with intraoperative application of @entity230 , @entity3201 -coated Nucleus 24 Contour, and @entity3201 -coated Nucleus 24 Contour with intraoperative application of @entity230 were compared. RESULTS: @entity134 application reduced impedances significantly throughout the observation period of up to 4 years after implantation. @entity27213 coating had no effect. Differences between the groups were mainly found on the basal and middle parts of the cochlea, but not close to the tip of the array, also indicating that postoperative fibrous tissue growth is stronger in the basal region of the cochlea. Group mean values of the stimulation effect were not influenced by the different treatments. Nevertheless, only in both @entity134 -treated groups a correlation between the impedance before stimulation and the stimulation effect was found. CONCLUSION: Although the differences between control and @entity134 -treated groups decrease with time, single intraoperative intracochlear @entity134 deposition was proven to lower postoperative impedances during first 3 to 4 years after implantation probably because of reduction of fibrous tissue growth.

title: The long-term effects of modified electrode surfaces and intracochlear corticosteroids on postoperative impedances in cochlear implant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity27213 :: ('MESH:C044458', 'Chemical') :: ['Iridium oxide', 'iridium oxide']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['Steroid', 'steroid']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: To understand the role of ovulation-inducing factor (or nerve growth factor) (OIF [NGF]) in @entity291 seminal plasma, we (1) used an in vivo @entity7857 bioassay to test the hypothesis that @entity291 seminal plasma induces ovulation and CL development in @entity7857 similar to that of @entity7857 seminal plasma when the dose of seminal plasma is adjusted to ovulation-inducing factor content (experiment 1) and (2) determined the effect of @entity291 seminal plasma on the interval to ovulation and luteal development in heifers (experiment 2). Within species, seminal plasma was pooled (n = 160 bulls, n = 4 @entity7857 ), and the volume of seminal plasma used for treatment was adjusted to a total dose of 250  g of ovulation-inducing factor. In experiment 1, mature female @entity7857 were assigned randomly to four groups and treated intramuscularly with either 10 mL of PBS (negative control, n = 5), 50- g @entity1176 (positive control, n = 5), 6-mL of @entity7857 seminal plasma (n = 6), or 12 mL of bull seminal plasma (n = 6). Ovulation and CL development were monitored by transrectal ultrasonography. In experiment 2, beef heifers were given a luteolytic dose of @entity3009 followed by 25-mg porcine LH (pLH) 12 hours later to induce ovulation. Heifers were assigned randomly to three groups and given 12 mL @entity291 seminal plasma intramuscularly 12 hours after pLH treatment (n = 10), within 4 hours after ovulation (n = 9), or no treatment (control, n = 10). Ovulation was monitored by ultrasonography every 4 hours, and the CL development was monitored daily until the next ovulation. In experiment 1, ovulation was detected in 0/5, 4/5, 4/6, 4/6 @entity7857 in the PBS, @entity1176 , @entity7857 seminal plasma, and @entity291 seminal plasma groups, respectively (P < 0.05). Luteal development was not different among groups. In experiment 2, the interval to ovulation was more synchronous (range: 4 vs. 22 hours; P < 0.0001) in heifers treated with seminal plasma before ovulation compared with the other groups. Luteal development was not different among groups; however, plasma @entity1420 concentrations tended to be greater in the postovulation treatment group compared with other groups. In summary, results confirmed the presence of bioactive ovulation-inducing factor in bull seminal plasma and supported the hypothesis that @entity291 and @entity7857 seminal plasma have similar ovulatory effects, using a @entity7857 bioassay. Treatment with @entity291 seminal plasma resulted in greater synchrony of ovulation in heifers pretreated with pLH. Plasma @entity1420 concentration tended to be higher in heifers given @entity291 seminal plasma within 4 hours after ovulation, suggesting that @entity291 ovulation-inducing factor is luteotrophic.

title: Bioactivity of ovulation inducing factor (or nerve growth factor) in @entity291 seminal plasma and its effects on ovarian function in XXXX .

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: UNASSIGNED: The notion that @entity6398 act as direct free radical scavengers is being challenged by mere chemical and biochemical considerations such as bioavailability and intracellular concentrations. An alternative hypothesis that is gaining considerable traction is that @entity6398 are processed by the body as xenobiotics via the @entity13792 / @entity13791 /ARE signaling axis, leading to the induction of Phase II enzymes. However, there are no solid @entity1 data to confirm this interesting supposition. In this study, we tested the activities of @entity36719 (HT) on Phase II enzymes' expression in a double-blind, randomized, placebo-controlled study. We tested two HT doses, i.e. 5 and 25mg/d, vs. placebo following a Latin square design. We report that HT is well tolerated but does not significantly modify Phase II enzyme expression in peripheral blood mononuclear cells. Moreover, we were unable to record significant effects on a variety of surrogate markers of @entity65 such as lipid profile and @entity32 and oxidation markers. Available evidence indicates that the "hormesis hypothesis" that @entity6398 activate Phase II enzymes requires solid @entity1 confirmation that might be provided by future trials. This study is registered at ClinicalTrials.gov (identifier: NCT02273622).

title: One-week administration of @entity36719 to XXXX does not activate Phase II enzymes.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity36719 :: ('MESH:C005975', 'Chemical') :: ['hydroxytyrosol']

entities_list: @entity6398 :: ('MESH:D059808', 'Chemical') :: ['(poly)phenols']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: OBJECTIVE: @entity1109 ( @entity1109 , ie, hot flashes or night sweats) are reported by many, but not all, @entity1 . The extent to which @entity1109 are genetically determined is unknown. We evaluated the relationship of genetic variation and @entity1109 . METHODS: In this observational study, we accessed data from three genome-wide association studies (GWAS) (SNP Health Association Resource cohort [SHARe], WHI Memory Study cohort [WHIMS+], and Genome-Wide Association Studies of Treatment Response in Randomized Clinical Trials [GARNET] studies, total n = 17,695) of European American, African American, and Hispanic American postmenopausal @entity1 aged 50 to 79 years at baseline in the @entity1 's Health Initiative Study. We examined genetic variation in relation to @entity1109 (yes/no) in each study and using trans-ethnic inverse variance fixed-effects meta-analysis. A total of 11,078,977 single-nucleotide polymorphisms (SNPs) met the quality criteria. RESULTS: After adjustment for covariates and population structure, three SNPs (on chromosomes 3 and 11) were associated with @entity1109 at the genome-wide threshold of 5 * 10 in the African American SHARe GWAS, but were not associated in the other cohorts. In the meta-analysis, 14 SNPs, all located on chromosome 4 in the @entity23737 ( @entity23737 ) locus, however, had P < 5 * 10. These SNPs' effect sizes were similar across studies/ @entity1 ' ancestry (odds ratio    1.5). CONCLUSIONS: Genetic variation in @entity23737 may contribute to the risk of @entity1109 . To our knowledge, this is the first GWAS to examine SNPs associated with @entity1109 . These results support the biological hypothesis of a role for @entity23737 in @entity1109 , which was previously hypothesized from animal and @entity1 studies. Further study of these variants may lead to new insights into the biological pathways involved in @entity1109 , which are poorly understood.

title: Association of genetic variation in the @entity23737 locus with hot flashes and night sweats in the XXXX 's Health Initiative Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'human', 'Women']

entities_list: @entity23737 :: ('6870', 'Gene') :: ['tachykinin receptor 3', 'TACR3']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['VMS', 'Vasomotor symptoms']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: The extent to which malignant cells deviate from normal is generally accepted to be a prognostic indicator. However, assessing the degree of deviation has been subjective and poorly reproducible. Our goal is to develop a computer program for objectively measuring nuclear size, shape, and texture from histologic slides and to make the program available on the Internet. We used this program to analyze 353 histologic sections obtained from @entity1 with invasive @entity0 who were diagnosed and treated from 1981 through 1995 and who had determinable outcomes. The median follow-up was 8.3 years. We compared the relationship of survival with our computer-derived nuclear features versus axillary lymph node status and @entity5 size. We believe that our results are generally applicable because our @entity1 survival, when stratified by lymph node status, was similar to that of the 24,000 @entity0 @entity1 in the National @entity5 Institute's Surveillance, Epidemiology, and End Results program. In multivariate analysis, the strongest prognostic factor was the largest nuclear area, followed by @entity5 size and the extent of axillary lymph node involvement. The mean area of the 3 largest nuclei when combined with @entity5 size identified 30% of all @entity0 @entity1 who had an 87% 15-year @entity0 -specific survival. Inclusion of lymph node status added little to this 2-factor model. Routine axillary lymph node surgery for prognostic purposes may become unnecessary, because nuclear features may provide sufficient information.

title: Computer-generated nuclear features compared with axillary lymph node status and XXXX size as indicators of @entity0 survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: Malignant fibrous histiocytoma of the liver is an extremely rare @entity5 . A 43-year-old @entity1 was admitted with an enlargement of the abdomen and a feeling of general fatigue. A clinical examination revealed a right liver @entity5 (18.5  *  22  cm). The @entity5 , which contained a solid component, occupied almost the entire right lobe of the liver, and a solid S4 @entity5 was also observed. A blood examination revealed severe @entity417 and mild @entity409 . During hospitalization intratumor @entity548 occurred. A right lobectomy of the liver and lymph node dissection was performed after transcatheter @entity1416 . Histopathologically, the @entity5 was diagnosed as a primary storiform-pleomorphic-type @entity1418 of the liver. One year after the radical operation, the @entity1 developed recurrences in other organs. She received 17 cycles of chemotherapy with @entity2879 , @entity1260 , and @entity900 . The recurrent @entity5 decreased in size, but new recurrences in other organs occurred. The @entity1 died of @entity1576 4  years and 2  months after the initial operation.

title: Four-year survival of a @entity1 with XXXX of the liver treated with surgery and chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1418 :: ('MESH:D051677', 'Disease') :: ['malignant fibrous histiocytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cystic tumor', 'giant cystic tumor', 'tumors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver dysfunction']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

answer: @entity1418 :: (MESH:D051677,Disease) :: ['malignant fibrous histiocytoma']


abstract: PURPOSE: To evaluate the long-term clinical outcome and @entity137 of conventional and three-dimensional conformal radiotherapy for @entity5 and paranasal sinuses. METHODS AND MATERIALS: Between January 1976 and February 2003, 127 @entity1 with histologically proven @entity5 of the paranasal sinuses (n = 119) or nasal cavity (n = 8) were treated with preoperative (n = 61), postoperative (n = 51), or primary (n = 15) radiotherapy, using conventional (n = 74) or three-dimensional conformal (n = 53) techniques. No elective neck irradiation of the cervical lymph nodes was performed in N0 @entity1 . RESULTS: Median follow-up was 5.6 years (range, 3-307 months) for all @entity1 , and 7.3 years (range, 47-307 months) for @entity1 still alive at the close-out date. The actuarial 5-year local control, overall survival, and disease-free survival rates were 53%, 54%, and 37%, respectively. Only 6 (5%) of all 127 @entity1 and 4 (3%) of 122 originally N0 @entity1 developed a regional failure in the neck. Distant @entity3 occurred in 20% of @entity1 . Both @entity5 extent and lymph node involvement were the most important prognostic factors, together with @entity957 histology. CONCLUSION: Local failure remains the dominant cause of poor outcome for @entity1 with @entity5 , despite aggressive local treatment with combined surgery and radiotherapy in operable @entity1 . Distant @entity3 and certainly regional relapse were much less common sites of failure. Overall survival remains poor, suggesting the need for more efficacious local and possibly systemic therapy.

title: XXXX and paranasal sinuses: long-term outcome with conventional or three-dimensional conformal radiotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies of the nasal cavity', 'cancer', 'primary tumor', 'sinonasal cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Malignancies of the nasal cavity']


abstract: Alterations of serum immunoglobulins, @entity7893 ( @entity7893 ), are a frequent finding in @entity134 sensitive @entity1985 (SSNS). The exact mechanisms are unclear, especially the persistence of @entity7893 into remission. Therefore we studied serum immunoglobulins M, A and G including IgG subclasses 1-4 in 44 @entity1 with SSNS; 14 were studied during relapse (RL) and 30 in remission (RM). Data were compared with those of 23 healthy controls. In a subgroup of 23 @entity1 (12 in RM and 11 in RL) we also studied IgG-1 specific antibodies to @entity116 toxoid and IgG-2 specific antibodies to pneumococcus antigen. Increased serum concentrations of IgM in RL and reduction of serum IgG in RL and RM were confirmed. During relapse, @entity7893 was characterized to result from deficiency of IgG-1-3, whereas in early phases of relapse the reduction was due to low IgG-1 only. In RM the deficiency of IgG-2 persisted for 12 months and correlated strongly with the duration of remission ( R=0.60, P<0.0001). IgG-4 levels were not altered in SSNS. In addition, IgG-2 specific antibodies to pneumococcus antigen were significantly reduced only in RL compared to RM ( P<0.05). In conclusion, @entity7893 of SSNS is characterized by a different constitution of IgG subclasses. In RL a reduction of serum levels of IgG-1-3 occurs, while low concentrations of IgG-2 might be the explanation for @entity7893 in remission of SSNS.

title: Serum levels of immunoglobulins and IgG subclasses in XXXX sensitive @entity1985 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity7893 :: ('MESH:D000361', 'Disease') :: ['hypogammaglobulinemia', 'especially hypogammaglobulinemia', 'HG']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome']

answer: @entity134 :: (CHEBI:35341,Chemical) :: ['steroid']


abstract: BACKGROUND: A significant minority of @entity1 receiving cardiac resynchronization therapy (CRT) remain nonresponsive to this intervention. OBJECTIVE: This study aimed to determine whether @entity301 ( @entity301 ) or baseline peripheral venous (PV) levels of established and emerging @entity712 ( @entity712 ) biomarkers are predictive of CRT outcomes. METHODS: In 73 @entity1 (aged 68    12 years; 83% @entity1 ; ejection fraction 27%    7%) with @entity301 and PV blood samples drawn simultaneously at the time of CRT device implantation, we measured @entity1472 -terminal pro-B-type natriuretic peptide (NT-proBNP), @entity14813 ( @entity14813 ), and soluble @entity8389 (sST2) levels. NT-proBNP concentrations >2000 pg/mL, @entity14813 concentrations >25.9 ng/mL, and sST2 concentrations >35 ng/mL were considered positive on the basis of established PV cut points for identifying "high-risk" individuals with @entity712 . CRT response was adjudicated by the @entity712 Clinical Composite Score. A major adverse cardiovascular event (MACE) was defined as the composite end point of @entity204 , cardiac transplant, left ventricular assist device, and @entity712 hospitalization at 2 years. RESULTS: NT-proBNP concentrations were 20% higher in the @entity301 than in the periphery, while @entity14813 and sST2 concentrations were 10% higher in the periphery than in the @entity301 (all P < .001). There were 45% CRT nonresponders at 6 months and 16 (22%) @entity1 with MACE. Triple-positive @entity301 values yielded the highest specificity of 95% for predicting CRT nonresponse. Consistently, @entity301 strategies identified @entity1 at higher risk of developing MACE, with >11-fold adjusted increase for triple-positive @entity301 @entity1 compared to triple-negative @entity1 (all P  <= .04). PV strategies were not predictive of MACE. CONCLUSION: Our findings suggest that @entity301 sampling of @entity712 biomarkers may be better than PV sampling for predicting CRT outcomes. Larger studies are needed to confirm our findings.

title: Coronary sinus biomarker sampling compared to peripheral venous blood for predicting outcomes in @entity1 with severe XXXX undergoing cardiac resynchronization therapy: The BIOCRT study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CS', 'coronary sinus']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']