abstract: UNASSIGNED: 3745 Background: @entity1 mast cells (MC) are subdivided into two subsets according to the expression of proteases: MCt positive only for tryptase and MCtc positive for both tryptase and @entity3920 . Their biological role in @entity5 progression is almost unknown. METHODS: We studied the expression patterns of MCt and MCtc in relation to microvessel density (MVD) and other known clinicopathological parameters in 87 primary @entity14 ( @entity14 ) to determine their prognostic significance. Intratumoral and normal peritumoral MC and MVD (CD31+) were analyzed by immunohystochemistry. Positivity was assessed in five areas of 1.2 mm(2). Areas of high number of MC and MVD positivity ("hotspot") were also counted. Overall survival, at five years follow-up was determined. RESULTS: A very high correlation between the two methods to evaluate MC or MDV positivity was found (p<0,01). MCt and MCtc were less frequent inside the @entity5 than in the normal adjacent mucosa, being MCt the predominant phenotype. A positive correlation between the number of MCt and MVD was found (p<0.01). When we analyzed the relationship between MCt, MCtc or MVD and the main clinicopathological features, we found differences in MCt and MVD according to Duke's stage classification. Thus, @entity1 classified as Duke A always presented the lowest values for both types of MC and MCV. Besides, we found that the number of intratumoral MCt correlated positively with lymphatic and /or blood vessel invasion (p<0.05). To assess prognosis, @entity1 were divided into two groups according to high and low MCt, MCtc or MVD expression. Univariate study indicates a non significant association between high intratumoral MCt and low MCtc. Unexpectedly, a significant association between low MVD expression and bad outcome was found. By multivariate analysis, intratumoral MVD was found to be an independent prognostic indicator. CONCLUSIONS: MCt, MCtc and MVD in @entity14 , is less frequent in @entity5 from @entity1 with low stage. Although, high intratumoral MCt and low MCtc was observed in @entity5 from @entity1 with bad outcome, only MVD showed to be an independent prognostic marker. No significant financial relationships to disclose.

title: Prognostic relevance of tryptase and @entity3920 positive mast cells and neoangiogenesis in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CCR', 'colorectal carcinomas']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinomas']


abstract: OBJECTIVE: To investigate whether @entity2287 -based contrast agent (GBCA) administration significantly affects diffusion-weighted imaging (DWI) at 3  T in the evaluation of @entity263 and benign tissue. METHOD: Thirty-four consecutive @entity1 with surgically proven @entity263 underwent preoperative DWI at 3  T before and after GBCA administration. Exponential apparent diffusion coefficient (EADC) and ADC maps were developed from DWI data. The ADC and EADC values pre- and post-contrast were measured in the @entity5 and benign tissue, respectively. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were evaluated on pre- and post-contrast DWI. RESULTS: The ADC and EADC values of the @entity5 and benign transition zone were not significantly different between pre- and post-contrast, respectively (P   >   0.05), while those in the benign peripheral zone were significantly different (P   =   0.030 and 0.037, respectively). In all tissues, the SNRs and CNRs of the DWI, ADC map and EADC map were not significantly different between pre- and post-contrast (P   >   0.05). Between pre- and post-contrast, ADC and EADC values showed excellent agreement (intraclass correlation coefficient   >=    0.894) and variability of  <=3.2  %. CONCLUSION: Prostate 3  T-DWI after GBCA administration may be used without a significant difference in SNR or CNR, with minimal variability of the @entity5 ADC and EADC values. KEY POINTS:     ADCs and EADCs have excellent agreement before and after @entity2288 administration.     SNRs of prostate DWI are similar before and after @entity2288 administration.     CNRs of @entity5 are similar between pre- and post-contrast DWI.

title: Prostate diffusion-weighted imaging at 3T: effect of intravenous XXXX administration.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer']

entities_list: @entity2288 :: ('MESH:C090600', 'Chemical') :: ['gadobutrol']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

answer: @entity2288 :: (MESH:C090600,Chemical) :: ['gadobutrol']


abstract: BACKGROUND: A variety of stent designs has been studied for endoscopic stenting of the bile duct in @entity1 with @entity5 . Although metal stents are associated with longer patency, their costs are significantly higher than plastic stents. AIMS: To compare clinical outcome and cost-effectiveness of endoscopic metal and plastic stents for @entity5 by a systematic review and meta-analysis of all randomized controlled trials in this area. METHODS: We conducted searches to identify all randomized controlled trials in any language from 1966 to 2006 using electronic databases and hand-searching of conference abstracts. Meta-analysis was performed with RevMan software [Review Manager (RevMan) version 4.2 for Windows. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2003]. RESULTS: Seven randomized controlled trials were identified that met the inclusion criteria, and 724 @entity1 were randomized to either metal or plastic endoscopic stents. No significant difference between the two stent types in terms of technical success, therapeutic success, 30-day mortality or complications was observed. Metal stents were associated with a significantly less relative risk (RR) of stent occlusion at 4 months than plastic stents [RR, 0.44; 95% confidence interval (CI) 0.3, 0.63; P<0.01]. The overall risk of recurrent @entity253 was also significantly lower in @entity1 treated with metal stents (RR, 0.52; 95% confidence interval 0.39, 0.69; P<0.01). The median incremental cost-effectiveness ratio of metal stents was  1820 per endoscopic retrograde cholangiopancreatography prevented. CONCLUSION: Endoscopic metal stents for @entity5 are associated with significantly higher patency rates than plastic stents as early as 4 months after insertion. Metal stents will be cost-effective if the unit cost of additional endoscopic retrograde cholangiopancreatographies per @entity1 exceeds  1820.

title: Do the benefits of metal stents justify the costs? A systematic review and meta-analysis of trials comparing endoscopic stents for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary obstruction']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant biliary obstruction']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant biliary obstruction']


abstract: BACKGROUND: The aim of the present study was to determine whether raised pre-operative serum @entity1011 increased the risk of @entity177 after liver resection. METHOD: Data were studied from 1535 consecutive liver resections. Outcomes in @entity1 with pre-operative @entity1011 </=124 micromol/l (Group 1) were compared with those with pre-operative @entity1011 >/=125 micromol/l (Group 2). RESULTS: The median age of the 1446 (94.3%) @entity1 resected in Group 1 was 62 years compared with 67 years in the 88 (5.7%) @entity1 in Group 2 (P < 0.0001). Similarly this latter group had double the number of @entity1 who were American Society of Anesthesiologists (ASA) III or IV (34.1% vs. 15.2%, P= 0.00004). Overall, the incidence of post-operative @entity177 requiring haemofiltration was low (0.9%) but significantly more in Group 2 @entity1 (5.7% vs. 0.6, P= 0.0007). In addition, @entity1 in Group 2 were more likely to suffer @entity810 post-operatively (18.2% vs. 4.3%, P < 0.0001). @entity1 with @entity810 had significantly higher @entity190 . Although there was no difference in mortality, @entity1 in Group 2 had higher post-operative morbidity (37.5%) than Group 1 (21.7%, P= 0.0006), with the incidence of @entity532 being higher in Group 2 (25.9% vs. 8.9%, P= 0.0025). CONCLUSIONS: After liver resection, @entity177 is rare but @entity1 with an elevated @entity1011 pre-operatively are at an increased risk of both @entity8 .

title: The impact of pre-operative serum XXXX on short-term outcomes after liver resection.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal and non-renal complications']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['cardiorespiratory complications']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity1011 :: (MESH:D003404,Chemical) :: ['creatinine']


abstract: The raphe-reticular connection in the @entity35 was studied using the @entity575 impregnation and peroxidase techniques. The raphe nuclei, were found to constitute two independent groups: the oblongata ( @entity17473 . raphealis magnus et parvus) and the pontomesencephalic groups (nuclei lineares, @entity17473 . raphealis dorsalis and @entity17473 . centralis superior). Inside each group the nuclei of either group are interconnected through the raphe-raphe projection but no such raphe-raphe connection exists between the two groups. The raphe reticular connection follows much the same pattern of development in either group: each group of raphe nuclei supplies the medial as well as the lateral reticular formation at its frontal level and at all more rostral levels. Through their efferents the raphe nuclei of the oblongata supply the @entity17473 . ventralis medullae oblongate, the @entity17473 . gigantocellularis, @entity17473 . pontis caudalis et oralis, @entity17473 . pedunculo-pontinus, @entity17473 . cuneiformis, and area prerubralis. The raphe nuclei of the oblongata do not send any projections to the more rostral levels. In the small-cell, lateral reticular formation the raphe efferents of the oblongata contribute to the @entity17473 . dorsalis medullae oblongate and @entity17473 . parvocellularis. The raphe-reticular fibres run in a diffuse bundle localized in the dorsolateral parts of the reticular formation along the dividing line between the medial and lateral reticular formations. The ponto-mesencephalic raphe nuclei send their efferents into the @entity17473 . pontis oralis, @entity17473 . pedunculo-pontinus, @entity17473 . cuneiformis, and into the area prerubralis. The ascending fibres then extend on rostrally into the diencephalon. The raphe-reticular bundle of these fibres passes diffusely through the dorsomedial portions of the reticular formation. Most of the efferents of the raphe nuclei of the ponto-mesencephalic group arise from the @entity17473 . raphealis dorsalis and @entity17473 . linearis caudalis. The @entity17473 . centralis superior sends mainly raphe-raphe connections to the two above mentioned nuclei. The rest of the efferents of the @entity17473 . centralis superior are merely poorly developed.

title: The raphe-reticular connection. An experimental study using the XXXX impregnation and horseradish peroxidase techniques in the @entity35 .

answer: @entity575 :: (MESH:D012834,Chemical) :: ['silver']


abstract: UNASSIGNED: 255 Background: Adult survivors of childhood @entity5 who received radiation therapy have high rates of @entity1491 and @entity320 compared with the general population. Both the National @entity5 Institute and @entity1 's Oncology Group Guidelines recommend regular skin self-checks and annual clinical skin exams for survivors. The ongoing ASK randomized intervention trial aims to identify strategies, including use of mobile health technology, which may improve early detection practices. METHODS: @entity1 previously treated with radiation and had no previous history of @entity1489 were identified, and eligible @entity1 are currently being enrolled. 800 @entity1 are being randomized into: (1) @entity1 activation and education (PAE) including targeted print and web-based materials and monthly text messages prompting skin checks and driving @entity1 to the ASK website; (2) PAE + physician activation (PAE + @entity601 ) adding targeted physician activation/educational materials about survivors' increased @entity1489 risk and recommendations for conducting full-body skin examinations; (3) PAE + @entity601 + teledermoscopy (PAE + @entity601 + @entity8527 ). The @entity8527 group receives a dermatoscope that attaches to their smartphone to photograph suspect moles for review by the study dermatologist. RESULTS: To date, 1,302 survivors are eligible. In the first five months of recruitment, 80% of the initial 400 eligible @entity1 have responded to the study invitation and 248 @entity1 (62%) have enrolled. Twenty-six percent of @entity1 have visited the website and 12 images of suspicious moles have been submitted for review. Completion of recruitment is anticipated by spring 2016. CONCLUSIONS: The ASK study addresses screening barriers by providing educational and motivational information for both survivors and physicians on the value of regular and thorough skin examinations. It also determines whether use of innovative mobile health technology activates survivors to conduct skin self-examinations, request physician examinations, and obtain treatment when @entity75 are found. CLINICAL TRIAL INFORMATION: NCT 02046811.

title: Advancing Survivors' Knowledge (ASK) about XXXX study: A randomized intervention within the @entity5 Survivor Study (CCSS).

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Children', 'patient', 'Participants']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancer']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['worrisome lesions']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma']

answer: @entity1489 :: (MESH:D012878,Disease) :: ['skin cancer']


abstract: Adult @entity649 has been reported after endoscopic variceal sclerotherapy with @entity8191 . It has been proposed that sclerosant entering the pulmonary circulation during intravariceal injections may cause @entity120 and @entity130 . The purpose of this study was to determine whether variceal sclerotherapy with @entity8191 causes @entity130 or @entity3126 in @entity1 . We studied the effect of sclerotherapy on gas exchange and pulmonary and systemic hemodynamics in 8 @entity1 who required endoscopic variceal sclerotherapy for treatment of @entity548 . The pulmonary vascular resistance index increased from 246 +/- 67 dyn X s X cm-5/m2 (mean +/- SEM) at baseline to a high of 303 +/- 85 dyn X s X cm-5/m2 60 min after sclerotherapy (normal range 250-500 dyn X s X cm-5/m2). Pulmonary artery pressure remained stable while cardiac index decreased by 12% over the same period. There were also small increases in systemic vascular resistance index and systemic arterial pressure after sclerotherapy. Although there was no change in arterial @entity26 tension, the alveolar-arterial @entity26 difference improved after sclerotherapy. These results indicate that variceal sclerotherapy with @entity8191 is associated with clinically insignificant changes in pulmonary and systemic hemodynamics. We did not detect evidence of @entity647 after sclerotherapy.

title: Effect of endoscopic variceal sclerotherapy on gas exchange and hemodynamics in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['variceal hemorrhage']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity8191 :: ('MESH:D012976', 'Chemical') :: ['sodium morrhuate']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['capillary injury']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: UNASSIGNED: The regulation of post-ischemic @entity4854 plays an important role in suppressing @entity528 in therapeutic strategies for @entity2806 . We previously reported that the cerebral @entity1372 - @entity413 transporter (SGLT) was involved in the post-ischemic @entity4854 -induced exacerbation of @entity2806 . Cortical @entity7078 , one of the cerebral SGLT isoforms, is dramatically increased by focal @entity2806 . In this study, we focused on the involvement of cerebral @entity7078 in the development of @entity2806 . It was previously reported that activation of @entity1920 -activated protein kinase (AMPK) increases @entity7078 expression. Moreover, ischemic stress-induced activation of AMPK exacerbates @entity2806 . Therefore, we directly confirmed the relationship between cerebral @entity7078 and cerebral AMPK activation using in vitro primary culture of @entity19 cortical neurons. An in vivo @entity19 model of focal @entity2806 was generated using a @entity2500 ( @entity2500 ). The development of @entity1188 volume and behavioral abnormalities on day 3 after @entity2500 were ameliorated in cerebral @entity7078 knock down @entity19 . Cortical and striatal @entity7078 expression levels were significantly increased at 12h after @entity2500 . Immunofluorescence revealed that @entity7078 and the @entity7079 ( @entity7079 ) were co-localized in the cortex and striatum of @entity2500 @entity19 . In the in vitro study, primary cortical neurons were cultured for five days before each treatment with reagents. Concomitant treatment with @entity273 and @entity413 induced the elevation of @entity7078 and phosphorylated AMPK/AMPK ratio, and this elevation was suppressed by compound C, an AMPK inhibitor in primary cortical neurons. Moreover, compound C suppressed neuronal cell death induced by concomitant @entity273 / @entity413 treatment in primary cortical neurons. Therefore, we concluded that enhanced cerebral @entity7078 function mediated by post-ischemic @entity4854 exacerbates the development of @entity2806 . One of the mechanisms of cerebral @entity7078 up-regulation may be involved in the AMPK activation after @entity2806 .

title: Activation of cerebral @entity1372 - XXXX transporter type 1 function mediated by post-ischemic @entity4854 exacerbates the development of @entity2806 .

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemic neuronal damage', 'cerebral ischemia']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion']

entities_list: @entity1920 :: ('CHEBI:16027', 'Chemical') :: ["5'-adenosine monophosphate"]

entities_list: @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage']

entities_list: @entity7079 :: ('52897(Tax:10090)', 'Gene') :: ['neuronal nuclear antigen', 'NeuN']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: BACKGROUND: Achievement of complete conduction block across left @entity339 ( @entity339 ) is challenging. Anticipation of perimitral conduction time (PMCT) associated with @entity616 may expedite this procedure. We evaluated the relationship between the preprocedural variables and the quantum of PMCT in @entity1 with bidirectionally blocked @entity339 . METHODS AND RESULTS: We reviewed clinical and echocardiographic parameters in 290 consecutive @entity1 with confirmed bidirectional @entity616 during @entity955 ( @entity955 ) ablation. PMCT was defined as the temporal delay to the latest of the double potentials on the line of block while pacing posteroseptal to it in the left atrium (LA). LA size and type of @entity955 significantly influenced PMCT in multivariate analysis. A cumulative score based on LA size (0   45 mm; 1>45 mm) and type of @entity955 (0: paroxysmal; 1=nonparoxysmal) ranged from 0 to 2. PMCT was directly correlated to the cumulative score (0: 169 ms; n=78; 95% confidential interval, 156 to 181); 1: 187 ms; n=103; 95% confidential interval, 178 to 196; 2: 209 ms; n=109; 95% confidential interval, 200 to 217). In 61 @entity1 who underwent @entity955 ablation twice, the difference between 2 PMCT values was <30 ms in 75% @entity1 . Another consecutive 143 @entity1 with and without @entity616 after at least 15 minutes of radiofrequency application were analyzed. Perimitral conduction delay <130 ms ruled out bidirectional @entity616 . Perimitral conduction delay >173 ms predicted bidirectional block with an accuracy of 86%. CONCLUSIONS: LA size and @entity955 type significantly influence PMCT in @entity1 undergoing successful @entity339 ablation. These parameters can be used to predict the time value associated with @entity616 , preprocedurally.

title: Preprocedural clinical parameters determining perimitral conduction time during XXXX line ablation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['MI', 'mitral isthmus']

answer: @entity339 :: (MESH:D008944,Disease) :: ['mitral isthmus']


abstract: 1. The plasma protein binding characteristics of @entity2756 , a new cephalosporin antibiotic, were determined in @entity1 , @entity3474 , @entity95 , @entity235 and @entity35 plasma. 2. The protein binding of @entity2756 was similar and concentration-dependent in @entity1 , @entity3474 , @entity95 and @entity35 plasma, being highly bound (90-95%) at low concentrations (less than 100 micrograms/ml) but considerably less bound (approx. 60%) at high concentrations (greater than 400 micrograms/ml). Binding in @entity235 plasma was also concentration-dependent but much lower (approx. 25%) at lower concentrations (30 micrograms/ml) and virtually unbound (2%) at high concentrations (1 mg/ml) over a similar concentration range. 3. Binding of @entity2756 to @entity1 plasma involved two sites: a high affinity-low capacity (saturable) site and a low affinity-high capacity site. Binding to @entity235 plasma apparently was at a single, high affinity-low capacity site. 4. The pharmacokinetics of @entity2756 in an animal species with binding characteristics similar to @entity1 ( @entity3474 ), appear to be non-linear when based on total drug concentration and linear when based on the free drug concentration. In the @entity235 , pharmacokinetic parameters did not change appreciably if calculated from total or free drug concentrations, due to the low protein binding.

title: Plasma protein binding of XXXX .

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

answer: @entity2756 :: (MESH:D002443,Chemical) :: ['ceftriaxone']


abstract: OBJECTIVE: Given the pleiotropic effect of @entity7784 ( @entity8393 ), it is interesting to know whether @entity8393 is capable of improving @entity28 . Here we examined the anti- @entity28 effect of @entity8393 in @entity19 with two distinct models of @entity28 . RESEARCH DESIGN AND METHODS: Male C57BL/6J @entity19 were fed a high-fat/high- @entity969 diet (25.0% [w/w] fat, 32.5% [w/w] @entity969 ) (HF/HS group) or a high-fat diet (38.1% [w/w] fat, 8.5% [w/w] @entity969 ) (HF group) for 4-20 weeks. A total of 5% @entity8393 was administered by partially substituting @entity8393 for fat in the HF/HS + @entity8393 and HF + @entity8393 groups. RESULTS: Both the HF/HS and HF groups similarly developed @entity28 . @entity8393 treatment strongly suppresses body weight gain and @entity28 -related @entity4854 and @entity3190 in HF/HS-fed @entity19 (HF/HS + @entity8393 group), where hepatic @entity412 content and lipogenic enzymes are increased. There is no appreciable effect of @entity8393 on body weight in HF-fed @entity19 (HF + @entity8393 group) without enhanced expression of hepatic lipogenic enzymes. Moreover, @entity8393 is capable of reducing hepatic @entity412 secretion and changing VLDL @entity844 composition in the HF/HS group. By indirect calorimetry analysis, we also found that @entity8393 is capable of increasing energy consumption in the HF/HS + @entity8393 group. CONCLUSIONS: This study is the first demonstration that the anti- @entity28 effect of @entity8393 in HF/HS-induced @entity28 is associated with the suppression of hepatic lipogenesis and @entity1560 . Because the @entity209 is often associated with hepatic lipogenesis and @entity1560 , the data suggest that @entity8393 is suited for treatment of the @entity209 .

title: Antiobesity effect of XXXX in high-fat/high- @entity969 diet-induced @entity28 : importance of hepatic lipogenesis.

entities_list: @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

answer: @entity7784 :: (MESH:D015118,Chemical) :: ['eicosapentaenoic acid']


abstract: We have prospectively investigated the effect of @entity5532 ( @entity10775 ) administration (2 gi.v. after every haemodialysis session for 6 months) on the normocytic and normochromic @entity417 of seven haemodialysis @entity1 . None had either clinical or analytical data characteristic of chronic @entity5715 intoxication. At the end of @entity10775 therapy, the haematocrit had increased from 20.5 +/- 2.7% to 30.4 +/- 7.7% (P less than 0.005), and the transfusional requirements decreased from 3.5 +/- 2.2 units (range 1-8 units) in the 6 months prior to @entity10775 , to 0.7 +/- 0.9 units (range 0-2 units) during @entity10775 administration (P less than 0.01). No transfusion was required during the second half of the @entity10775 therapy period. Serum ferritin decreased from 105g +/- 532 nmol/l (2649 +/- 1331 ng/ml) to 507 +/- 403 nmol/l (1268 +/- 1008 ng/ml) (P less than 0.025). Two months after @entity10775 withdrawal the haematocrit value fell significantly to 22.2 +/- 1.6% (P less than 0.01). @entity10775 therapy was restarted in one @entity1 at a lower dose (1 gi.v. after every haemodialysis session) and an increase of haematocrit from 23.8% to 40.2% was again observed after 3 months of treatment. The tolerance to @entity10775 was excellent. We conclude that @entity10775 therapy should be considered in haemodialysis @entity1 with severe @entity417 and increased blood transfusion requirements.

title: Improvement of @entity417 with XXXX in haemodialysis @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5532 :: ('MESH:D003676', 'Chemical') :: ['desferrioxamine']

entities_list: @entity5715 :: ('CHEBI:28984', 'Chemical') :: ['aluminium']

answer: @entity5532 :: (MESH:D003676,Chemical) :: ['desferrioxamine']


abstract: The possibility of using alteration in the ventricular gradient (VG) to discern the presence of @entity741 was studied in 30 @entity1 with @entity951 (AP), 21 with @entity951 ( @entity951 ), 21 with @entity662 ( @entity662 ), and 20 healthy volunteers (control). The VG of each consecutive heart beat over a 22-sec interval was calculated by microcomputer from resting Frank-lead X, Y, Z scalar electrocardiograms. The mean values and @entity5494 ( @entity5494 ) for the azimuth, elevation, and magnitude of the VG in each group were calculated. The @entity5494 and @entity5494 /mean ratios for each parameter were used as indices of VG alteration in the groups, and the indices were compared. The @entity5494 and @entity5494 /mean for the magnitude and elevation of VG were significantly greater in the AP group than in the @entity662 and control groups. The @entity5494 for the azimuth of VG was significantly greater in the AP group than in the @entity662 and control groups (p < 0.01). The @entity5494 and @entity5494 /mean for the magnitude of VG were greater in the AP group than in the @entity951 group (p < 0.01). The @entity5494 /mean for the elevation and magnitude of the VG were greater in the @entity951 group than in the control group (p < 0.01). The @entity5494 /mean of the magnitude of the VG was found to be the best index, as it was higher than the upper limit of the control group. The sensitivity and specificity were 80 and 91% (AP vs @entity662 , p < 0.001), and 43 and 91% ( @entity951 vs @entity662 , not significant), respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Alteration in ventricular gradient at rest in @entity1 with XXXX ].

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain syndrome', 'CPS']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['standard deviations', 'SD']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['effort angina pectoris', 'vasospastic angina', 'VSA']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

answer: @entity741 :: (MESH:D017202,Disease) :: ['ischemic heart disease']


abstract: @entity6720 (OX) is one of the number @entity1245 used therapeutically as a sedative-hypnotic and anti- @entity148 agent. OX is also a common metabolite of many other @entity1245 . Since they are among the most widely prescribed drug, the evaluation of their potential genotoxic activity should be considered very important. In the present study cytochalasin B-blocked binucleate @entity1 lymphocytes have been used to measure micronucleus induction after treatment with @entity6720 . The frequency of micronuclei (MN) were analysed in 72 hours culture of peripheral blood @entity1 lymphocytes. OX was added to the cultures at the beginning of the cultivation period. The concentrations in cultures was 0.5; 5; 10; 25 and 50 mg/ml. It was found that all used @entity6720 concentrations induced formation of micronuclei. MN frequencies were significantly increased (except for concentration 0.5 mg/ml OX) in relation to the control (cultures without OX). Number of binuclear lymphocytes with micronuclei, as well as number of micronuclei per a binuclear lymphocytes stand in correlation with the strength of tested concentrations--there was a dose-response. On the basis of our results we can conclude that long time administrated of OX may represent a potential hazard to @entity1 health.

title: [Genotoxicity of XXXX --the micronucleus cytochalasin-B test].

entities_list: @entity6720 :: ('MESH:D010076', 'Chemical') :: ['Oxazepam', 'oxazepam']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines']

answer: @entity6720 :: (MESH:D010076,Chemical) :: ['oxazepam']


abstract: @entity130 ( @entity130 ) can provide useful criteria for subtyping @entity4521 -dependent @entity1 , since @entity130 have been related to an @entity4784 and they hinder @entity1 management. The frequency of nine varieties of moderate/superficial @entity130 during active @entity4521 use was assessed retrospectively in 164 @entity4521 -dependent @entity1 . A principal component analysis of @entity130 episodes revealed a four-component solution which accounted for 69.3% of the variance. The components were named as follows (percentage of variance explained by each component is enclosed in parentheses): ' @entity130 with objects' (27.3%), ' @entity130 by biting/scratching/hair-pulling' (18.2%), ' @entity130 by hitting' (12.3%), and ' @entity130 by picking scabs' (11.5%). A cluster analysis using the results of the principal component analysis enabled us to define three types of @entity4521 -dependent @entity1 , labelled: 'low-occurrence @entity130 cluster' (59.8%), 'high-occurrence scab-picking cluster' (31.7%) and 'high-occurrence hitting and cutting cluster' (8.5%). @entity130 by hitting was the most discriminatory component among clusters: its frequency was at a minimum in the low-occurrence @entity130 cluster, and attained a maximum in the high-occurrence hitting and cutting cluster. However, there were no differences among clusters regarding @entity4521 -use variables. @entity1 from the low-occurrence @entity130 cluster, compared with those from the other two clusters, reported fewer episodes of @entity130 or suicide attempts and were diagnosed less frequently with @entity6426 . @entity1 from the high-occurrence scab-picking cluster had a very frequent history of these @entity130 , while the opposite was true in @entity1 from the high-occurrence hitting and cutting cluster. @entity1 from this cluster probably presented staff members with the main management problems.

title: A typology of XXXX -dependent @entity1 based on their history of self-injurious behaviours.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid system dysfunction']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Self-injurious behaviours', 'SIB']

answer: @entity4521 :: (MESH:D003932,Chemical) :: ['heroin']


abstract: OBJECTIVE: To assess the relationship between @entity0 ( @entity0 ) detected on screening mammography and @entity731 of carotid arteries considering the most likely involved layer of the arterial wall. MATERIALS AND METHODS: A total of 537 consecutive @entity1 who underwent screening mammography were enrolled in this study. Seventy-nine subjects having @entity0 , aged 46-75 years, and 125 age-matched controls from those without @entity0 were selected for ultrasound examination of carotid arteries assessing @entity121 ( @entity121 ) and plaque presence. @entity1 were divided into three groups of risk including, low-risk: @entity121 <0.6mm without plaque, medium-risk: 0.6mm <= @entity121 <=0.8mm without plaque and high-risk: @entity121 >0.8mm and/or plaque. Risk factors for @entity731 were obtained from medical records for independent effects. RESULTS: @entity0 was present in 14.7% of mammograms. According to multivariable logistic regression analyses, significant association was identified between the @entity2998 risk and presence of @entity0 . Compared to @entity1 with @entity121 <0.6mm, those with 0.6mm <= @entity121 <=0.8mm and @entity121 >0.8mm had OR (95% CI) of 4.88 (1.47-16.16) and 23.36 (4.54-120.14), respectively. The OR (95% CI) for carotid plaque was 3.13 (1.3-7.57). There was no interaction between @entity121 category and plaque. Significant associations were also detected with postmenopausal duration (P=0.02) and @entity101 (P=0.004). CONCLUSION: The risk of @entity2998 increases with the presence of @entity0 . @entity1 with @entity0 are more likely to have thicker @entity121 than plaque, which could be attributed to the preferentially similar affected layer of media causing thick @entity121 rather than plaque.

title: @entity0 and risk of XXXX : focusing on the preferentially affected layer of the vessel wall.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'Participants']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['BAC', 'breast arterial calcification']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']


abstract: To determine the value of chest roentgenographic findings in the diagnosis and therapy of @entity378 we analysed roentgenograms of 41 @entity1 with endoscopically confirmed tuberculous involvement of the intrathoracic airways. 40 @entity1 had infiltrates typical for @entity1907 . Signs of diminished air entry in form of collapse or consolidations were found in 52%. 10 @entity1 had cavities and two had a destroyed lung. In only one @entity1 the chest roentgenogram was completely normal demonstrating a case of @entity378 . During antituberculosis drug therapy radiological signs improved in 38 of 41 @entity1 , but in more than half of the cases stenoses persisted as verified by bronchoscopy. We conclude that @entity378 is usually accompanied by lung parenchyma involvement and that roentgenological findings are characterised by signs of @entity1907 in most cases. A normal chest roentgenogram does not exclude @entity378 . Despite roentgenographic improvement during therapy tracheobronchial stenoses may persist. These findings justify to perform early fibreoptic bronchoscopy. Sputum conversion during the clinical course may indicate the most appropriate time for this examination.

title: [Roentgen findings in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['endobronchial tuberculosis', 'isolated endobronchial tuberculosis']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis', 'pulmonary tuberculosis predominantly in the upper lobes']

answer: @entity378 :: (MESH:D014376,Disease) :: ['bronchial tuberculosis']


abstract: INTRODUCTION: Primary @entity764 are rare @entity361 and their mainstay of therapy is wide surgical resection. We report our single-institution, multidisciplinary experience with full-thickness resection for primary @entity764 . METHODS: A retrospective review of our prospectively maintained databases revealed that 51 @entity1 were referred for primary @entity764 from 1990 to 2009. RESULTS: All @entity1 required resections that included rib and/or sternum. Twenty-nine @entity1 (57%) had extended resections beyond the chest wall. Forty-two @entity1 (82%) required prosthetic reconstruction and 17 @entity1 (33%) had muscle flap coverage. Overall, 51% (26/51) of @entity1 received neoadjuvant therapy. Seventy-three percent (11/15) of high-grade soft tissue @entity242 , 77% (10/13) of high-risk @entity242 , and 67% (4/6) of @entity765 were treated with induction therapy. Negative margins were obtained in 46 @entity1 (90%). There were no perioperative mortalities. Eight @entity1 (16%) experienced complications. Local recurrence and @entity3 was detected in 14 and 23%. Five-year overall and disease-free survivals were 66% and 47%, respectively. Favorable prognostic variables for survival included age  <=50 years, @entity5 volume  <=200 cm, @entity765 , @entity5 , @entity511 , and low-grade soft tissue @entity242 . CONCLUSIONS: We report our multidisciplinary experience with primary @entity764 that included induction therapy in the majority of high-risk soft tissue and @entity242 and @entity765 . Despite aggressive preoperative treatments, acceptable surgical results with low morbidity and mortality can be achieved. Neoadjuvant systemic therapy may reduce local and distant recurrence and improve overall survival.

title: Single-institution, multidisciplinary experience with surgical resection of primary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas', 'bony sarcomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'bony tumor']

entities_list: @entity765 :: ('MESH:D018222', 'Disease') :: ['desmoid tumor', 'desmoid tumors']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['chest wall sarcomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors']

answer: @entity764 :: (MESH:D013898,Disease) :: ['chest wall sarcomas']


abstract: OBJECTIVES: To evaluate the use of fixed distance side to side comparison of @entity8807 ( @entity8807 ) and first dorsal interosseous (FDI) compound muscle action potential (CMAP) studies in the diagnosis of @entity16 . MATERIALS AND METHODS: Thirty normal controls underwent @entity8807 and FDI CMAP studies bilaterally at a fixed @entity8807 recording to stimulating point distance of 6 cm. Side to side mean latency differences to both muscles were calculated. Twenty @entity1 with suspected @entity16 from routine nerve conduction studies had positive results when compared with controls. RESULTS: The upper limit of normal for side to side mean latency difference at 3 SD above the mean was 0.394 and 0.474 ms for @entity8807 and FDI, respectively. All 20 @entity1 had side to side mean CMAP latency difference above 3 SDs in the @entity8807 , FDI or both muscles. Fifty percent of cases had involvement of the superficial sensory branch. CONCLUSIONS: Fixed distance side to side CMAP latency comparison is a useful electrodiagnostic adjunct for @entity16 . @entity130 was the most common aetiology in the 20 reported cases. Correlation was found between aetiological factors and sites of lesions as localized with this method.

title: Clinical and electrophysiological aspects of XXXX .

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['distal ulnar neuropathy', 'unilateral distal ulnar neuropathy']

entities_list: @entity8807 :: ('MESH:C536354', 'Disease') :: ['abductor digiti minimi', 'ADM']

answer: @entity16 :: (MESH:D009422,Disease) :: ['distal ulnar neuropathy']


abstract: The dominant-submissive relationship established between two @entity35 competing for food is a model of @entity308 and is used here to divide animals into two behaviorally distinct groups. Basal and @entity1246 -stimulated 36CI- uptake was investigated for both dominant and submissive @entity35 as well as the in vitro effect of the antidepressant @entity3659 ( @entity3660 ). Because the antidepressant action of @entity3660 only appears after chronic treatment, the effect of chronic injections of @entity3660 on these behavioral and biochemical measures was also studied. Basal 36CI- uptake is significantly higher for dominant @entity35 than for submissive @entity35 . Increasing concentrations of @entity3660 added to membrane vesicles enhanced 30 microM @entity1246 -stimulated @entity2865 uptake for dominant @entity35 and inhibited it for submissive @entity35 . Chronic treatment of dominant and submissive @entity35 with @entity3660 reversed these in vitro effects. The biochemical data correspond to the changes of the @entity35 behavior in the dominance test after chronic treatment with @entity3660 . However, this correlation is more clear for dominant than for submissive @entity35 . Specific @entity2865 influx was used as a measure of the sensitivity of GABAA receptor to @entity1246 . This revealed different sensitivity states for GABAA receptors in tissues obtained from dominant and submissive @entity35 . It is possible that the distinct conformational states of GABAA receptor are responsible for differences in @entity35 behavior and in vitro effects of @entity3660 before and after in vivo treatment of @entity35 with this anti-depressant.

title: Effects of @entity3659 on @entity1246 -stimulated 36CI- uptake in relation to a behavioral model of XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity3659 :: ('MESH:D000639', 'Chemical') :: ['amitriptyline']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: BACKGROUND: Phenotypic expressions of @entity455 vary throughout the body and it is not clear to what extent systemic @entity731 influences brain arterial remodeling. We aim to test the hypothesis that systemic @entity731 is associated with brain arterial diameters. METHODS: @entity64 -free @entity1 in the Northern Manhattan Study MRI subcohort in whom carotid ultrasound, transthoracic echocardiogram, and brain MRA (n = 482) were performed were included in this analysis. Brain arterial diameters were measured with semi-automated software as continuous and categorical variables. Ultrasound and echocardiography provided the sum of maximum carotid plaque thickness (sMCPT) and aortic plaque thickness. Associations between brain arterial diameters and aortic and carotid plaque thickness were assessed with semi-parametric generalized additive models. RESULTS: Aortic plaque thickness was inversely and linearly associated with brain arterial diameters (B per mm = -0.073    0.034, p = 0.03), while sMCPT was associated nonlinearly in a u-shaped curve with anterior brain arterial diameters (spline regression   2 = 9.19, p = 0.02). Coexisting carotid and aortic @entity731 were more prevalent in @entity1 with small luminal diameters (40%) compared with @entity1 with average (30%) or with large (13%) luminal diameters, while @entity2998 without aortic @entity731 was more prevalent among @entity1 with large luminal diameters (31%) compared with those with average (12%) or small luminal diameters (2%, p < 0.001 for both trends). CONCLUSIONS: We confirmed the hypothesis that systemic @entity455 is associated with brain arterial diameters. Gaining knowledge about the origin of these phenotypic expressions of @entity731 in the @entity1 body may lead to a better understanding of the cerebrovascular consequences of the systemic @entity455 .

title: Systemic XXXX Relate to Brain Arterial Diameters: The Northern Manhattan Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'human']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']


abstract: OBJECTIVE: To assess parenchymal bolus-triggering in terms of liver enhancement, lesion-to-liver conspicuity and inter-image variability across serial follow-up MDCTs. METHODS: We reviewed MDCTs of 50 @entity1 with hepatic metastases who had a baseline CT and two follow-up examinations. In 25 consecutive @entity1 CT data acquisition was initiated by @entity409 triggering at a 50-HU enhancement threshold. In a matched control group, imaging was performed with an empirical delay of 65 s. CT attenuation values were assessed in vessels, @entity409 and @entity3 . Target lesions were classified according to five enhancement patterns. RESULTS: Compared with the control group, liver enhancement was significantly higher with parenchyma triggering (59.8    7.6 HU vs. 48.8    11.2 HU, P = 0.0002). The same was true for conspicuity ( @entity409 - lesion attenuation) of hypo-enhancing lesions (72.2    15.9 HU vs. 52.7    19.4 HU, P = 0.0006). Liver triggering was associated with reduced variability for liver enhancement among different @entity1 (P = 0.035) and across serial follow-up examinations in individual @entity1 (P < 0.0001). The number of @entity1 presenting with uniform lesion enhancement pattern across serial examinations was significantly higher in the triggered group (20 vs. 11; P = 0.018). CONCLUSION: Liver parenchyma triggering provides superior lesion conspicuity and improves standardisation of image quality across follow-up examinations with greater uniformity of enhancement patterns. KEY POINTS: Liver parenchyma tracking improves liver enhancement and lesion-to-liver conspicuity in abdominal CT. In serial CT studies this technique reduces variability of conspicuity and enhancement patterns. Higher liver-to-lesion conspicuity is a prerequisite for reliable detection of @entity409 . Stabilisation of enhancement permits more accurate follow-up of oncology @entity1 .

title: Standardisation of liver MDCT by tracking XXXX enhancement to trigger imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver parenchyma', 'liver lesions']

answer: @entity409 :: (MESH:D008107,Disease) :: ['liver parenchyma']


abstract: To establish clinical and histologic determinants of survival, records of all UCLA @entity1 with resectable @entity320 metastatic to the lymph nodes during the years 1954-1976 were reviewed. These 150 @entity1 were treated first with wide excision, lymphadenectomy, and with radiation/chemotherapy and/or additional surgery only if further recurrences developed. None received adjuvant immunotherapy or chemotherapy. In 97 of 139 @entity1 with identified @entity5 , slides of the @entity75 were reviewed. Putative prognostic factors included age, sex, parity, site of @entity5 , presence of satellitosis, clinical status of nodes, histologic characteristics of @entity75 (Clark's level, thickness of @entity5 , presence/width of @entity1066 , and number of mitoses/HPF), time from biopsy of @entity5 to lymphadenectomy, and number of positive nodes. kaplan-Meier estimates of survival for the entire group at one, two, five, and ten years were 73, 55, 37, and 33%, respectively. Median follow-up period of survivors was four years. Univariate analyses using the log-rank test showed that thickness of the @entity75 (p less than 0.001), width of @entity1066 (p = 0.003), absence of @entity1066 (p = 0.024), and number of positive nodes (p = 0,.033) were prognostic for survival. In multivariate analysis by the Cox procedure, thickness of the primary (p = 0.001) and number of @entity320 -containing nodes (p = 0.043) were prognostic for survival. Location of the @entity5 became marginally significant (p = 0.12) in the multrivariate model. These findings demonstrate the prognostic importance of characteristics of both the @entity75 and extent of regional dissemination. Future prospective randomized trials for (adjuvant) therapy of @entity320 should be stratified by these variables.

title: Factors prognostic for survival in @entity1 with XXXX spread to the regional lymph nodes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'primary tumor']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'Stage II melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']


abstract: @entity409 are amongst the most serious health problems in the world today and @entity157 is one of the world's @entity5 . The aim of the current study was to evaluate the protective effect of sider honey and/or @entity9052 extract (KGE) against @entity4314 ( @entity14605 )-induced hepato-nephrotoxicity in @entity35 . Eighty male Sprague-Dawley (SD) @entity35 were allocated into different groups and over a 4-week period, they orally received honey and/or KGE or were treated either with @entity14605 alone (100 mg/kg b.w) or with @entity14605 after a pretreatment period with honey, KGE or a combination of both. Clinical, clinico-pathological and histopathological evaluations were done and @entity14605 -treated groups were compared with @entity35 receiving no treatment and with @entity35 given honey, KGE or a combination of these substances. The results indicated that oral administration of @entity14605 induced severe @entity8 associated with oxidative stress. The combined treatment with @entity14605 plus honey and/or KGE resulted in a significant improvement in all evaluated parameters. This improvement was prominent in the group receiving @entity14605 after combined pretreatment with honey and KGE. Animals receiving honey and/or KGE (without @entity14605 -treatment) were comparable to the control untreated group. It could be concluded that honey and KGE protect SD @entity35 against the severe @entity14605 -induced hepatic and renal toxic effects. Our results suggest that the protective activity of honey and KGE may have been related to their antioxidant properties.

title: Dietary honey and XXXX protect against @entity4314 -induced hepatonephrotoxicity in @entity35 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['hepatic and kidney injury']

entities_list: @entity4314 :: ('MESH:D002251', 'Chemical') :: ['carbon tetrachloride']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['deadliest cancers']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver diseases']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity9052 :: ('4054', 'Species') :: ['Korean ginseng']

answer: @entity9052 :: (4054,Species) :: ['ginseng']


abstract: The aim of this work was to evaluate peripheral and abdominal @entity1386 ( @entity1386 ) content detected by MRI in normal weight and @entity28 @entity1 , to compare MRI data with simple anthropometric indexes and to estimate intrabdominal @entity1386 (IAT) influence on cardiovascular risk factors. The subjects were 23 @entity28 and 21 normal weight @entity1 aged 10 to 15 years. The following measurements were carried out: MRI analysis at lumbar level with definition of @entity1386 ( @entity1386 ) area and IAT area; @entity1386 ( @entity1386 ); thigh fat area (TFA) and waist/hip ratio from anthropometry. @entity1386 (353 +/- 94 cm2) was predominant compared with IAT (49 +/- 21 cm2) in @entity28 as well as in controls ( @entity1386 : 79 +/- 61 cm2; IAT: 22 +/- 11 cm2). No differences in @entity1386 /IAT ratio were found for sex and puberty, either in @entity28 subjects or in controls. @entity1386 and IAT were significantly related in controls (r = 0.77, P < 0.0001), but not in @entity28 subjects (r = 0.12, P = 0.59). IAT was related to total and LDL @entity165 and @entity1674 levels (r = 0.54, P < 0.02, r = 0.60, P < 0.01, r = 0.46, P < 0.04, respectively) in @entity28 @entity1 . @entity1386 and @entity13799 from anthropometry significantly underestimated @entity1386 compared with MRI in both groups. Methods agreement analysis showed unacceptable results for anthropometry. It was concluded that @entity28 has a subcutaneous adipose pattern with no differences between the sexes. IAT already begins to have clinical significance since it has a relationship to some cardiovascular risk factors.(ABSTRACT TRUNCATED @entity1386 250 WORDS)

title: Peripheral and abdominal adiposity in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['childhood obesity', 'obese']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['subcutaneous adipose tissue', 'adipose tissue', 'SAT', 'AFA', 'AT', 'arm fat area']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity28 :: (MESH:D009765,Disease) :: ['childhood obesity']


abstract: INTRODUCTION: @entity74 are associated with many diseases of the critically ill @entity1 . Early treatment with @entity4388 of these @entity209 is required for their normalization. This is an alkaline electrolyte solution administered by continuous or intermittent infusion. Its incompatibility due to its alkaline pH has been described, as it produces insoluble @entity6445 precipitation and causes @entity544 gas when mixed with acidic solutions. MATERIAL AND METHOD: An in vitro experimental study was performed. @entity3157 was mixed with 13 drugs simulating Y-site administration. We combined 5 ml @entity3157 with 5 ml of every drug, at highest daily concentration used. The samples were visually examined to detect color changes, cloudiness, precipitation or gas formation, pH measurement and spectrophotometric analysis at 450 nm and 620 nm. The samples were evaluated at 0, 15, 30, 60 and 120 minutes. The compatibility criteria were absence of visual changes, pH changes<0.5 and variability of absorbance <0.01. RESULTS: We studied each drug individually and mixed with @entity3157 with 27 samples, and 135 measurements were performed. The incompatibilities did not always produce visual changes. Knowing the pH of drugs does not guarantee the compatibility of the mixture. @entity1242 with pH 4 is compatible with @entity3157 . Thiopental with pH 11 makes precipitation. Higher absorbances showed color changes, cloudiness and precipitation. CONCLUSIONS: @entity3157 is physically compatible with @entity7368 , @entity1483 , heparin, insulin, @entity1286 , @entity3931 , @entity1242 and @entity3773 and incompatible with @entity2643 , @entity2897 , @entity1767 , @entity1363 and thiopental.

title: [Physical compatibility of XXXX with other drugs often administered in the intensive care unit].

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']

entities_list: @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate']

entities_list: @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone']

entities_list: @entity6445 :: ('CHEBI:41609', 'Chemical') :: ['carbonate']

entities_list: @entity1242 :: ('MESH:D005996', 'Chemical') :: ['Nitroglycerin', 'nitroglycerin']

entities_list: @entity3773 :: ('MESH:C015568', 'Chemical') :: ['urapidil']

entities_list: @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate', 'Bicarbonate']

entities_list: @entity3931 :: ('MESH:D009553', 'Chemical') :: ['nimodipine']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Acid-base disorders']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

entities_list: @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium']

answer: @entity4388 :: (MESH:D017693,Chemical) :: ['sodium bicarbonate']


abstract: A 75-year-old @entity1 with @entity712 and an ejection fraction of 15 % was treated with an @entity1289 -inhibitor, @entity1482 and a beta-blocker. He had reduced his intake of food and water due to an intercurrent illness the days before admission. He was admitted to our coronary care unit due to @entity1168 and @entity551 . On arrival his blood pressure was 60/40 mm Hg, and he was in a @entity1455 . The electrocardiogram showed broad QRS-complexes and large T waves. Serum- @entity972 was 9.1 mmol/L and he had @entity810 with @entity1458 , probably caused by @entity998 due to @entity3485 combined with taking an @entity1289 inhibitor and @entity1482 . Haemodialysis was started and during dialysis QRS complexes became more narrow and heart rate and blood pressure normalized. The @entity1 was discharged 10 days later with normal @entity972 and @entity1011 levels. @entity1 treated with @entity1289 -inhibitors and @entity1482 should be monitored closely. During @entity2700 may occur and this can lead to @entity177 and @entity4144 which can be life-threatening. The condition should be recognized and addressed promptly, and if indicated haemodialysis should be performed.

title: [An elderly XXXX with known @entity712 admitted with @entity1455 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patient', 'man']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['post-MI heart failure']

entities_list: @entity2700 :: ('MESH:D003681', 'Disease') :: ['intercurrent illness dehydration']

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['reduced cardiac output']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity1482 :: ('MESH:D013148', 'Chemical') :: ['spironolactone']

entities_list: @entity4144 :: ('MESH:D006947', 'Disease') :: ['hyperkalemia']

answer: @entity1 :: (9606,Species) :: ['man']


abstract: Elimination of auditory nerve activity results in rapid metabolic changes, cell atrophy, and cell death in @entity10789 ( @entity10789 ), the cochlear nucleus of the @entity1573 . The transneuronal signals involved in the activity-dependent regulation of @entity10789 neurons are not well understood. One of the most rapid transneuronal effects is alteration in protein synthesis by @entity10789 neurons. Previous studies using an in vitro preparation of the brain stem auditory system suggested that up-regulation of protein synthesis in @entity10789 neurons requires the action of some trophic substance released by active auditory nerve fibers. Here, similar results were obtained when measuring changes in immunoreactivity using a monoclonal antibody (Y10B) that recognizes ribosomal RNA. This immunolabeling assay has advantages over the global protein synthesis assay in that it is not sensitive to possible changes in specific activity of the precursor pool or possible differences in the uptake of the labeled @entity1522 . Unilateral stimulation of the auditory nerve for 1 h resulted in greater immunolabeling of @entity10789 neurons on the stimulated side of the slice. This is consistent with previous in vivo results after unilateral deafferentation. Blockade of synaptic transmission by maintaining the slice in a low- @entity141 /high Mg2+ medium prevented the stimulation-induced difference in immunolabeling. Electrical stimulation of the postsynaptic @entity10789 neurons alone (antidromic stimulation, via electrical stimulation of @entity10789 neuron axons) did not result in greater immunolabeling. Rather, antidromically stimulated neurons tended to show lighter labeling. Thus, the transneuronal regulation of ribosomes in @entity10789 neurons appears to require some substance released from the active auditory nerve.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Activity-dependent regulation of a ribosomal RNA epitope in the XXXX cochlear nucleus.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity10789 :: ('MESH:D002527', 'Disease') :: ['NM', 'nucleus magnocellularis']

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: @entity3179 are chronic wounds affecting up to 1% of adults in developed countries. Considering that noncontact normothermic therapy has been shown to modify the wound healing process, we conducted a prospective comparative clinical trial aimed at evaluating 980 nm diode laser in laser-assisted @entity3179 . Thirty-four Caucasian @entity1 with @entity3179 were included in the study and separated into two homogenous groups based on age, sex ratio, size, and etiologies of the @entity1066 . In the laser group, 980 nm InGasAs diode laser (power 15 W, spot size 8 mm, time 3 seconds, fluence 90 J/cm(2) ) was applied weekly for 9 weeks to the @entity1066 in a homogenous standardized manner, resulting in a local temperature of 45-50   C, which was controlled with a thermal infrared camera. Complete healing, reduction in size, and @entity158 during and between each procedure were evaluated each time. Of the 18 @entity1 in the laser group, three (16.7%) were completely healed during laser treatment. In the control group (16 @entity1 ), the healing was complete for four @entity1 (25%). This difference was not significant (p=0.62). At the ninth follow-up visit, in the control group, the @entity1066 had decreased on an average to 94.3% of the original area of the @entity1066 . In the laser group, the decrease was to 74.2% of the original area of the @entity1066 . Again, this difference was not significant (p=0.60). The mean VAS score between each treatment was 2.7 (0.5-4.4) in the laser group compared with 3.8 (2.3-5.0) in the control group (0.13<p<0.86). During the treatment, the mean VAS score was 1.8 (0.2-3.8) in the laser group compared with 3.8 (2.1-6.0) in the control group (0.08<p<0.67). 980 nm diode laser-assisted @entity3179 was easy to perform and very well tolerated. However, there were no statistically significant differences in reduction of @entity1066 size between the two groups, suggesting that this particular laser regimen does not promote wound healing. Additional studies involving larger @entity1 populations and an increased frequency of treatment should be performed to confirm our initial conclusions.

title: A prospective randomized study of 980 nm diode laser-assisted XXXX on 34 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcer healing', 'venous leg ulcers', 'Venous ulcers']

answer: @entity3179 :: (MESH:D014647,Disease) :: ['venous ulcer healing']


abstract: AIMS: The aims of this study were to determine whether yoga and hydrotherapy training had an equal effect on the health-related quality of life in @entity1 with @entity712 and to compare the effects on exercise capacity, clinical outcomes, and symptoms of @entity148 and @entity308 between and within the two groups. METHODS: The design was a randomized controlled non-inferiority study. A total of 40 @entity1 , 30% @entity1 (mean  SD age 64.9  8.9 years) with @entity712 were randomized to an intervention of 12 weeks, either performing yoga or training with hydrotherapy for 45-60 minutes twice a week. Evaluation at baseline and after 12 weeks included self-reported health-related quality of life, a six-minute walk test, a sit-to-stand test, clinical variables, and symptoms of @entity148 and @entity308 . RESULTS: Yoga and hydrotherapy had an equal impact on quality of life, exercise capacity, clinical outcomes, and symptoms of @entity148 and @entity308 . Within both groups, exercise capacity significantly improved (hydrotherapy p=0.02; yoga p=0.008) and symptoms of @entity148 decreased (hydrotherapy p=0.03; yoga p=0.01). @entity1 in the yoga group significantly improved their health as rated by EQ-VAS ( p=0.004) and disease-specific quality of life in the domains symptom frequency ( p=0.03), self-efficacy ( p=0.01), clinical summary as a combined measure of symptoms and social factors ( p=0.05), and overall summary score ( p=0.04). Symptoms of @entity308 were decreased in this group ( p=0.005). In the hydrotherapy group, lower limb muscle strength improved significantly ( p=0.01). CONCLUSIONS: Yoga may be an alternative or complementary option to established forms of exercise training such as hydrotherapy for improvement in health-related quality of life and may decrease @entity308 in @entity1 with @entity712 .

title: Effects of yoga versus hydrotherapy training on health-related quality of life and exercise capacity in @entity1 with XXXX : A randomized controlled study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: INTRODUCTION: @entity320 is a rare condition corresponding to less than 1% of all eyelid @entity5 . The aim of the current study is to present the experience of our department. @entity1 AND METHODS: From 1986 to 2009, 972 @entity1 with a @entity320 have been studied retrospectively. Each @entity1 was evaluated in relation with age, sex, location of the @entity5 , histology (Breslow and Clark included), surgical treatment, recurrence, and finally with follow up. RESULTS: Twenty-three @entity1 with @entity320 and a strong female incidence (69.5%) were identified. Median age was 68.3 years. In most cases (71.4%), @entity5 was located on the right inferior eyelid in continuity with the malar region. LMM had the higher incidence (60.8%), followed by the @entity320 (21, 7%) and the SSM. The median Breslow was 0.77 while the median @entity16208 .68. Surgery was the treatment of choice including direct closure, the use of full thickness skin graft and local or regional flaps. Three @entity1 had local recurrence associated to nodular metastases in one of them. CONCLUSION: Surgical treatment of @entity320 is a challenge for every reconstructive surgeon. Early detection remains the "gold standard" for every reconstructive option respecting the esthetic and function of this precious anatomic location.

title: [ XXXX : our experience a propos of 23 cases].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'eyelid melanoma', 'nodular melanoma', 'Eyelid melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Eyelid melanoma']


abstract: Dysregulation of apoptosis is a pilot event before @entity5 development and plays important roles for @entity5 to develop resistance to chemical therapeutics. So exploring strategies to recovery the apoptosis balance is a charming and long-endeavored aim in the attempts to conquer @entity5 . The present study shows an exciting potency of a fusion peptide to inhibit and target to @entity5 cells, which is composed of @entity2424 (Bcl-2 Homology 3) effector domain from @entity6396 (p53 upregulated modulator of apoptosis) and targeting domain of trans-activator of transcription (TAT) and DV3. The in vitro results demonstrated @entity5 growth inhibition by the fusion peptide in @entity694 cells, as well as in @entity2220 cell line and @entity0 cell line of @entity1 origin. But the viability of HEK293, a noncancerous cell line, was not affected, indicating the @entity5 specificity of the fusion peptide. Apoptosis activation was induced by the peptide through the mitochondria pathway. In vivo studies displayed its @entity5 inhibiting ability by intratumoral injection. When the fusion peptide was administered systematically by tail vein, the peptide targeted the established @entity5 in @entity19 . No other organs were significantly involved. The fusion peptide is an artificially designed molecule worthy of further evaluation and development.

title: XXXX -based fusion artificial peptide induces apoptosis and targets @entity1 @entity694 .

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer', 'tumors']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

answer: @entity2424 :: (MESH:C006008,Chemical) :: ['BH3']


abstract: Performance records were analyzed for 1,869 purebred Duroc and Yorkshire gilts tested in littermate groups of two to four @entity1707 in 703 pens. Traits studied were average daily gain during a standard test period from 56 d of age to 90.7 kg ( @entity9365 ), average daily feed consumption during the test period ( @entity9366 ), @entity121 ( @entity121 ) measured from polaroid photos of ultrasonic scans at 90.7 kg and efficiency of feed conversion for the whole test period (feed conversion efficiency, FCE). The main objectives were: 1) to estimate pertinent genetic and phenotypic parameters and 2) to discuss applications of the findings to the @entity1707 industry in the United States. A balanced 16% crude protein diet in pelleted form was provided ad libitum during the entire test period. Nested analyses of variance were computed with both the individual and pen mean records. Sire components of variance and covariance, adjusted for level of inbreeding, were used to estimate heritabilities and genetic and phenotypic variances, covariances and correlations. Heritabilities estimated from individual records were .098 for @entity9365 and .423 for @entity121 . Estimates from pen means were .105 for @entity9366 and .061 for FCE. Genetic correlations of FCE with @entity9365 , @entity9366 and @entity121 were estimated as -.520, -.520 and .694, respectively, while phenotypic correlations for the same traits were -.240, .570 and .212, respectively, all from pen means. Genetic and phenotypic correlations of @entity9365 with @entity121 from individual records were .176 and .254, respectively. Implications for @entity1707 testing programs were discussed, including a proposal that would include FCE indirectly in an index with @entity9365 and @entity121 , based on genetic covariances of FCE with @entity9365 and @entity121 , thereby removing the need to measure FCE directly.

title: A genetic analysis of feed conversion efficiency and associated traits in XXXX .

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['ABF', 'average backfat thickness']

answer: @entity1707 :: (9823,Species) :: ['swine']


abstract: BACKGROUND: It has been reported that combined therapy of @entity7774 converting enzyme inhibitor and @entity7774 receptor blocker significantly decreases @entity644 in immunoglobulin A (IgA) @entity8 . However, histologic alterations following the therapy have not been reported. METHODS: A total of nine Japanese @entity1 with severe @entity8 who received a prompt immunosuppressive therapy were enrolled the study, four of whom received a combined therapy of @entity7774 converting enzyme inhibitor, @entity4688 and @entity7774 receptor blocker, @entity9886 (Group A), while the remaining five did not (Group B). All underwent renal biopsy before and approximately 12 months after the first renal biopsy. RESULTS: At presentation, urine protein excretion and the histologic indices of mean activity index, mean chronicity index and tubulointerstitial scores did not show a statistical difference between the two groups: Group A (2.6 +/- 0.6 g/day; mean activity index, 5.0 +/- 1.0; mean chronicity index, 5.0 +/- 1.0; tubulointerstitial scores, 4.3 +/- 1.0) and Group B (2.2 +/- 0.6 g/day; mean activity index, 4.8 +/- 0.8; mean chronicity index, 4.8 +/- 1.3; tubulointerstitial scores, 3.6 +/- 0.5, respectively). All had normal blood pressure and renal function. Urine protein excretion and the activity index decreased at the second renal biopsy, while the chronicity index and the tubulointerstitial scores slightly increased or remained unchanged. In comparison with Group B, a significant suppression in increasing the chronicity index and the tubulointerstitial scores obtained at the second renal biopsy were observed in Group A [Group A: 4.3 +/- 1.2 and 3.0 +/- 0.0, respectively, vs Group B: 6.0 +/- 0.7 and 4.4 +/- 0.9, respectively (P < 0.05)]. One @entity1 in Group B developed @entity740 thereafter. CONCLUSIONS: Although only a small number of @entity1 were examined, these clinical findings suggest that a combined therapy of @entity4688 and @entity9886 may attenuate histologic progression in at least a proportion of @entity1 with severe @entity8 .

title: Combined therapy of @entity4688 and XXXX attenuates histologic progression in immunoglobulin A @entity8 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'proteinuric IgA nephropathy']

entities_list: @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril']

entities_list: @entity7774 :: ('MESH:D000809', 'Chemical') :: ['angiotensin']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic renal insufficiency']

entities_list: @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan']

answer: @entity9886 :: (MESH:D019808,Chemical) :: ['losartan']


abstract: OBJECTIVE: The Hybrid Capture II assay (hc2; QIAGEN, Inc) for high-risk @entity1082 (hrHPV) is an in vitro nucleic acid hybridization assay using chemiluminescence for the qualitative detection of hrHPV DNA in cervical samples. Results are reported as a ratio of relative light units (RLUs) to a cutoff value based on a positive control. Specimens with RLU ratios of 1.0 or higher are scored positive for hrHPV. We tested the hypothesis that hrHPV positives with low-positive RLU ratios (1-10) had a lower prevalence of @entity3146 2,3 ( @entity8046 2,3) on histologic follow-up. MATERIALS AND METHODS: Relative light unit ratios for 388 consecutive hrHPV-positive cervical cytologic specimens interpreted as @entity10479 ( @entity10479 ) were reviewed. Individual RLU ratios were compared with outcome histologic diagnosis in cases with colposcopic follow-up and tissue sampling (biopsy and/or endocervical curettage; n = 236). RESULTS: Of 236 cases with histologic follow-up, 63 had RLU ratios in the range of 1 to 10; of these, 53 (84.1%) were negative for @entity8046 , 7 (11.1%) had @entity8046 1, 1 (1.6%) had @entity8046 of uncertain grade, and 2 (3.2%) had @entity8046 2,3. The difference in @entity8046 2,3 outcome between RLU ratios of 1 to 10 (3.2%) versus over 10 (17.3%) was significant (p =.0047). The difference in prevalence of @entity8046 1 was not significant (p =.67). CONCLUSIONS: An RLU ratio of 10 or less was associated with a significantly lower prevalence of @entity8046 2,3 on biopsy outcome after a Pap test result of @entity10479 . The much lower prevalence of underlying @entity8046 2,3 in @entity1 who are weakly HPV-positive may justify modification of the management algorithm for this subset of @entity1 with @entity10479 .

title: A weakly positive XXXX Hybrid Capture II result correlates with a significantly lower risk of @entity3146 2,3 after @entity10479 cytology.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity10479 :: ('MESH:D065309', 'Disease') :: ['ASCUS', 'atypical squamous cells of undetermined significance']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus']

entities_list: @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus']


abstract: STUDY DESIGN: Retrospective chart review. PURPOSE: A comparison of mini open foraminotomy (MOF) for @entity614 using either large tubular (LT) or TrimLine (TL) retractors. OVERVIEW OF LITERATURE: Posterior foraminotomy relieves compression of the cervical nerve root in @entity614 @entity1 . However, invasion of the paravertebral muscle may cause major problems in these @entity1 . To address these problems, we performed MOF. METHODS: Twenty @entity614 @entity1 (16 male and 4 female) who underwent MOF between May 2004 and August 2011 were assigned to LT and TL groups. Each group contained 10 subjects. Surgical and clinical outcomes were compared. RESULTS: The average operating time in the TL group was significantly shorter than that in the LT group. The final follow-up mean neck disability indices significantly improved compared to the preoperative values (LT group, 12.0  7.8 vs. 28.0  9.4; TL group, 6.0  5.9 vs. 21.9  10). The final follow-up @entity4048 visual analog scale (VAS) scores also decreased significantly from the preoperative of 8.0  1.5 and 2.5  2.5 to the final follow-up values of 2.2  2.2 and 1.0  2.5 in the LT and TL groups, respectively. The recovery rate for the @entity4048 VAS score was 70.0  31.9 in the LT group and 87.0  32.0 in the TL group, thus suggesting no significant difference between the two groups. CONCLUSIONS: MOF with the TL retractor is an easy and safe procedure. Furthermore, the use of the TL retractor allows for a minimally invasive and effective surgical treatment of @entity614 @entity1 .

title: Mini Open Foraminotomy for XXXX : A Comparison of Large Tubular and TrimLine Retractors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['radiculopathy', 'cervical radiculopathy']

answer: @entity614 :: (MESH:D011843,Disease) :: ['Cervical Radiculopathy']


abstract: STUDY DESIGN: Cross-sectional study of total sagittal spinal alignment in @entity2649 ( @entity2649 ) @entity1 with and without @entity613 . OBJECTIVE: To evaluate total sagittal spinal alignment in @entity2649 . SUMMARY OF BACKGROUND DATA: The sagittal spinal alignment is an important factor in the management of @entity615 . @entity1 with @entity2649 accompanied by @entity613 adopt a forward-bending posture during walking. However, few studies have quantitatively assessed the abnormal posture in @entity2649 in relation to clinical symptoms. METHODS: This study analyzed 93 @entity1 with @entity2649 . They were divided into two groups according to the presence of neurogenic @entity613 ; @entity1 of the Claudicant group had @entity613 of the cauda equina (n = 53; mean age, 66.7) and those of the Nerve root group had no claudication (n = 40; mean age, 67.0). The following parameters were measured on the lateral whole-spine standing radiographs: the distance between the C7 plumb line and the posterior superior corner on the superior margin of S1 (sagittal vertical axis), the angle between the superior margin of the first lumbar vertebra and the first sacral vertebra (L1S1), lumbar lordotic angle, pelvic tilting angle (PA), and pelvic morphologic angle (PRS1). RESULTS: The sagittal vertical axis of the Claudicant group (57.6 +/- 37.5 mm) was significantly larger than that of the Nerve root group (40.3 +/- 42.3 mm) and was larger in both groups compared with the standard values. Lumbar lordotic angle was smaller (18.8 degrees +/- 13.2 degrees ) and pelvic tilting angle was larger (27.2 degrees +/- 8.3 degrees ) in @entity1 with the Claudicant group than those with the Nerve root group (22.4 degrees +/- 14.0 degrees and 22.7 degrees +/- 7.2 degrees , respectively). CONCLUSION: @entity1 of the Claudicant group exhibited forward bending of the trunk and pelvis backtilt, compared with those of the Nerve root group.

title: Total sagittal spinal alignment in XXXX with lumbar canal stenosis accompanied by @entity613 .

entities_list: @entity2649 :: ('MESH:C563613', 'Disease') :: ['LCS', 'lumbar spinal canal stenosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['lumbar degenerative diseases and lower back pain']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: We conducted a case-control study to examine the relationship between human leukocyte antigen-A ( @entity1529 ) allele polymorphism and the pathogenesis of cervical @entity5 among Japanese @entity1 . METHODS: A total of 119 @entity1 with invasive @entity957 were compared to 119 age- and menopausal status-matched non- @entity5 controls. Blood samples were taken from all cases and controls and lifestyle information was collected by means of a self-administered questionnaire. The estimated impact of @entity1529 alleles on cervical @entity5 risk was evaluated by unconditional logistic regression models. RESULTS: The frequency of @entity1529 (*)0206 among cases was significantly lower than among controls (P = 0.006). There was an inverse association between A(*)0206 and cervical @entity5 risk (odds ratio [OR] = 0.31, 95% confidence interval [95% CI] = 0.15 to 0.65, P = 0.002), and a positive association for @entity1529 (*)2402 (OR = 1.76, 95% CI = 1.00 to 3.09, P = 0.048). After correction for multiple comparisons, A(*)0206 was significantly associated with @entity5 risk (corrected P = 0.036). Furthermore, the inverse association between A(*)0206 and cervical @entity5 risk was independent of smoking status (never smoker: OR = 0.37, 95% CI = 0.15 to 0.90; ever smoker: OR = 0.23, 95% CI = 0.06 to 0.89). CONCLUSIONS: There was an inverse association between @entity1529 (*)0206 and cervical @entity5 risk among Japanese @entity1 , which suggests that @entity1529 polymorphism influences cervical @entity5 risk. Further investigation in other populations is thus warranted.

title: XXXX alleles and the risk of @entity957 in Japanese @entity1 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['reduced cervical cancer', 'cancer', 'neoplasia']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['cervical squamous cell carcinoma']

answer: @entity1529 :: (3105,Gene) :: ['HLA-A']


abstract: PURPOSE: Our aim was to evaluate the prognostic significance of @entity1082 ) genotype in early-stage @entity2622 primarily treated with surgery in a large tertiary referral medical center. @entity1 AND METHODS: Consecutive @entity1 who underwent primary surgery for invasive @entity2622 of International @entity13374 ( @entity13374 ) stage I to IIA between 1993 and 2000 were retrospectively reviewed. Polymerase chain reaction (PCR) using a general primer set followed by reverse-blot detection of 38 types of HPV DNA in a single reaction was performed for genotyping. E6 type-specific PCR was performed to validate multiple types. RESULTS: A total of 1,067 eligible @entity1 were analyzed. HPV DNA sequences were detected in 95.1% of the specimens, among which 9.6% contained multiple types. @entity1799 was detected in 63.8% of the samples, and HPV 18 was detected in 16.5% of the samples. The median follow-up time of surviving @entity1 was 77 months. By multivariate analysis, @entity13374 stage, lymph node @entity3 , depth of cervical stromal invasion, grade of differentiation, and HPV 18 positivity were significantly related to @entity5 relapse. @entity13374 stage II, deep stromal invasion, parametrial extension, HPV 18 positivity, and age older than 45 years were significant predictors for @entity204 . Using the seven selected variables from either recurrence-free or overall survival analysis, @entity204 -predicting (P < .0001) and relapse-predicting (P < .0001) models classifying three risk groups (low, intermediate, and high risk) were constructed and endorsed by internal validation. CONCLUSION: The independent prognostic value of HPV genotype is confirmed in this study. The prognostic models could be useful in counseling @entity1 and stratifying @entity1 in future clinical trials.

title: Role of XXXX genotype in prognosis of @entity5 undergoing primary surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity13374 :: ('MESH:D005831', 'Disease') :: ['Federation of Gynecology and Obstetrics', 'FIGO']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus']


abstract: OBJECTIVE: To assess the results of substitution cystoplasty for the treatment of intractable @entity2335 ( @entity2335 ). @entity1 AND METHODS: Thirty-two @entity1 (29 @entity1 and three @entity1 ; mean age 58 years, range 24-74) with intractable @entity2335 resistant to conservative therapy who had undergone substitution cystoplasty between 1983 and 1992 were reviewed. Their bladder capacities were measured pre-operatively and related to the outcome of treatment. RESULTS: All but two of the 22 @entity1 with a bladder capacity of < 250 mL under anaesthetic were improved (five) or cured (15) of their symptoms. The results in @entity1 with larger bladder capacities were much less reliable, with only two of seven being cured of their symptoms. The three @entity1 all had a good result. Those who had undergone supratrigonal cystectomy were more likely to void spontaneously, but four @entity1 developed @entity2885 from associated reflux. @entity146 and, although there were too few @entity1 for statistical significance, probably increased the chance of cure at the expense of increasing the need for intermittent self-catheterization (ISC). CONCLUSIONS: Pre-operative bladder capacity under anaesthetic is the most reliable predictor of outcome of substitution cystoplasty for treating intractable @entity2335 in @entity1 . It is contra-indicated if bladder capacity is > 250 mL. Supratrigonal cystectomy is a quick and easy operation and is preferable in the older @entity1 . Subtotal cystectomy with reimplantation of the ureters is preferable in the younger @entity1 , even though it may increase the need for ISC.

title: Substitution cystoplasty for intractable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['IC', 'interstitial cystitis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Subtotal cystectomy reduced the likelihood of reflux']

answer: @entity2335 :: (MESH:D003556,Disease) :: ['interstitial cystitis']


abstract: INTRODUCTION: @entity9847 is a glycogen storage disease caused by mutations in the @entity16861 gene encoding @entity16861 . It manifests classically with childhood-onset exercise-induced @entity158 . METHODS: We report the characteristics of 2 unrelated @entity1 with a new homozygous mutation of the @entity16861 gene. RESULTS: Two @entity1 , aged 76 and 79 years, presented with severe upper and lower limb @entity194 and @entity425 . Additionally, 1 @entity1 presented with bilateral @entity1736 , and the other with @entity3518 . In both @entity1 , symptoms had developed progressively in the 2 preceding years, and there was no history of exercise intolerance. Both @entity1 demonstrated @entity854 on EMG, multiple glycogen-containing vacuoles and undetectable muscle @entity16861 activity on muscle biopsy, and a novel homozygous frameshift @entity16862 *48 @entity16861 mutation. DISCUSSION: This report expands the phenotype and genotype of @entity9847 , and suggests that @entity16861 mutations should be looked for in @entity1 with very late-onset @entity121 with no previous history of exercise intolerance. This article is protected by copyright. All rights reserved.

title: A novel variant in the @entity16861 gene causing late-onset limb-girdle @entity121 , XXXX , and @entity3518 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity16862 :: ('p|SUB|K,P|42|RO', 'ProteinMutation') :: ['p.Lys42Profs']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity3518 :: ('MESH:C537968', 'Disease') :: ['camptocormia']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['myogenic abnormalities']

entities_list: @entity9847 :: ('MESH:D006012', 'Disease') :: ['McArdle disease']

entities_list: @entity16861 :: ('5837', 'Gene') :: ['PYGM', 'myophosphorylase']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy']

answer: @entity1736 :: (MESH:D001763,Disease) :: ['ptosis']


abstract: Infection of red blood cells (RBC) subjects the @entity311 parasite to oxidative stress. Therefore, efficient antioxidant and redox systems are required to prevent damage by reactive @entity26 species. @entity2637 spp. have thioredoxin and @entity2041 ( @entity2197 ) systems that are thought to play a major role as antioxidants during blood stage infection. In this report, we analyzed a critical component of the @entity2197 biosynthesis pathway using reverse genetics. @entity2637 parasites lacking expression of @entity2638 synthetase (gamma-GCS), the rate limiting enzyme in de novo synthesis of @entity2197 , were generated through targeted gene disruption thus demonstrating, quite unexpectedly, that gamma-GCS is not essential for blood stage development. Despite a significant reduction in @entity2197 levels, blood stage forms of pbggcs(-) parasites showed only a defect in growth as compared to wild type. In contrast, a dramatic effect on development of the parasites in the mosquito was observed. Infection of mosquitoes with pbggcs(-) parasites resulted in reduced numbers of stunted oocysts that did not produce sporozoites. These results have important implications for the design of drugs aiming at interfering with the @entity2197 redox-system in blood stages and demonstrate that de novo synthesis of @entity2197 is pivotal for development of @entity2637 in the mosquito.

title: The XXXX biosynthetic pathway of @entity2637 is essential for mosquito transmission.

entities_list: @entity2638 :: ('MESH:C017341', 'Chemical') :: ['gamma-glutamylcysteine']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity2637 :: ('5821', 'Species') :: ['Plasmodium', 'Plasmodium berghei']

answer: @entity2041 :: (MESH:D005978,Chemical) :: ['glutathione']


abstract: OBJECTIVES: Advances in nail-fold capillaroscopy allow @entity854 to be quantified. Our aim was to investigate, in @entity1 with SSc, the relationships between the degree of nail-fold @entity854 and disease subtypes (lcSSc and dcSSc), duration of @entity6391 and the presence of (i) severe digital ischaemia (as defined by previous i.v. vasodilators, debridements or amputations), (ii) a positive ACA, (iii) clinically evident @entity730 , (iv) @entity120 and (v) @entity8721 . METHODS: This was a retrospective study of 176 @entity1 . Six capillary measurements (four semi-automated and two manual) were calculated (automated width, distance between capillaries, tortuosity and derangement, and manual distance and density). Relationships between these measurements and the different clinical features of SSc were examined using multiple linear regressions (adjusted for age, sex and smoking status). RESULTS: One hundred and forty-two @entity1 had lcSSc and 34 had dcSSc. Sixty-eight (39%) had a history of severe digital ischaemia, 66 (38%) were anti-centromere positive, 53 (30%) had clinically evident @entity730 and 26 (15%) had an estimated pulmonary artery pressure of >30 mmHg. Positive associations were found between both automated and manually measured distance between capillaries and (i) presence of severe digital ischaemia and (ii) positive ACA, and reduced density was also associated with positive anti-centromere. @entity1 with moderate/severe @entity8721 had wider capillaries compared with those with 'mild' lesions. CONCLUSIONS: Both severe digital ischaemia and positive ACA are associated with measurable nail-fold capillaroscopic change, which has the potential of being an outcome measure for the structural microvascular disease associated with SSc-spectrum disorders.

title: Nail-fold XXXX are associated with anti-centromere antibody and severity of digital ischaemia.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectases']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary arterial hypertension']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcinosis']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['capillary abnormality', 'capillary abnormalities']

answer: @entity854 :: (MESH:D018376,Disease) :: ['capillary abnormalities']


abstract: The present study reports on @entity137 of @entity3838 derivative (HpD) for normal brain tissue in vivo without the addition of light. @entity3838 derivative was injected by slow infusion in @entity35 brains. Histological examination was carried out for intervals after HpD administration, ranging from 0 h to 15 days. Ultrastructural changes were examined with transmission electron microscopy. The extent of the @entity39 was determined for different HpD concentrations and compared with control animals infused with 0.9% saline. Leukocytic infiltration was observed at day 5. Transmission electron microscopy showed that nuclei of neurons were completely disintegrated 4 h after HpD administration. Furthermore disruption of myelin sheaths was observed. The extent of the @entity39 decreased with lower HpD doses. Injection of 2 micrograms HpD in a volume of 4 microL (0.5 mg/mL) resulted in a virtually equal extension of the tissue damage, as compared to the mechanical damage in the control animals caused by the infusion procedure.

title: Local neurotoxicity of XXXX derivative following intracerebral injection.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity3838 :: ('MESH:D006415', 'Chemical') :: ['hematoporphyrin', 'Hematoporphyrin']

answer: @entity3838 :: (MESH:D006415,Chemical) :: ['hematoporphyrin']