abstract: @entity955 is a supraventricular @entity591 very common in medical practice, often associated with @entity712 . Pathophysiological relationship between @entity955 and @entity712 is in the attention of numerous case studies, being incomplete elucidated. MATERIAL AND METHODS: We made a retrospective study on @entity1 with both diseases, hospitalized in Cardiovascular Rehabilitation Hospital, Iasi, during 01.01.2013 - 31.12.2013. The obtained data allowed the classification of @entity1 according to gender distribution, age groups, area of origin, clinical aspects, and association with other diseases, instituted treatment and appreciation of CHADS2 score. Data interpretation was performed with appropriate statistical methods. RESULTS: We found a higher frequency of the disease among male @entity1 , male: female ratio being 2:1; the most of the @entity1 lived in urban area. The pick of diseases incidence was in @entity1 over 65 years with a total percentage of 70.84% of cases. We noted that the most common symptoms were exertional @entity1353 (in all @entity1 ), palpitations, @entity1296 , @entity10 , @entity1295 , @entity1395 , @entity1353 at rest and @entity158 /chest pressure. In our study, the majority of @entity1 received the beta-blocker--digoxin combination (46 @entity1 , 40 @entity1 respectively). CONCLUSIONS: The coexistence of the two disorders could be explained by identifying common risk factors. Beta blockers should be the first therapeutic option in @entity1 with @entity712 and @entity955 because they have the effect of controlling heart rate and improve survival in @entity1 with these disorders. Meanwhile, digoxin is a drug, only certain conditions of high accuracy monitoring; whose major clinical indications are @entity712 and @entity132 .

title: Therapeutical considerations in associated XXXX and @entity712 .

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure', 'heart failure']

entities_list: @entity132 :: ('MESH:D010468', 'Disease') :: ['atrial rhythm disturbances']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachyarrhythmia']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial fibrillation']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: BACKGROUND: Good clinical results of main pancreatic duct (MPD) stent placement in @entity1689 ( @entity1689 ) are clouded by early @entity432 . The aim of this study was to increase knowledge about @entity432 and its effects on clinical symptoms, and to define criteria that enable the prediction of clogging. METHODS: A total of 100 pancreatic endoprostheses of 47 @entity1 (32 @entity1 , 15 @entity1 ; mean age, 53 years; standard deviation, 9 years) with @entity1689 were bench tested by simulating the pathophysiologically increased MPD pressure. The main study parameter was the reduction of water flow through clogged stents in comparison with native endoprostheses of identical type, length, and diameter. Major @entity432 was defined as flow reduction by > or = 75%. The association between time to @entity432 and stent- or @entity1 -related variables was evaluated. RESULTS: Occlusion took place in nearly all endoprostheses (97%). No significant association of occlusion with clinical or blood parameters was found. Multifactorial analysis proved 4 risk factors for major @entity432 : (A) stent diameter > 8.5F, (B) stent length > 8 cm, (C) female gender, (D) exocrine @entity3210 that required regular oral enzyme supplementation. According to the relative risk, these factors were given the following scores: A, 3 points; B to D, 2 points. Stents in @entity1 with a score sum > 5 showed a significantly higher risk of major @entity432 within 90 days. CONCLUSIONS: Stent clogging in @entity1689 seems to be an inevitable phenomenon. Because clinical and laboratory data do not reliably indicate clogging, stent removal or exchange should be performed in high-risk @entity1 (score sum > 5) within 3 months.

title: Pancreatic endoprostheses in XXXX : criteria to predict @entity432 .

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['stent occlusion']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity3210 :: ('MESH:D010188', 'Disease') :: ['pancreatic insufficiency']

entities_list: @entity1689 :: ('MESH:D050500', 'Disease') :: ['CP', 'chronic pancreatitis']

answer: @entity1689 :: (MESH:D050500,Disease) :: ['chronic pancreatitis']


abstract: UNASSIGNED: It has been well documented that @entity17211 is associated with impaired endothelium-dependent vasodilation. However, the exact molecular mechanism which mediates this process has not been fully described. The current study aimed to investigate the role of @entity17211 -induced @entity6198 inflammasome activation in @entity532 and its molecular mechanism. Male adult @entity30206 knockout @entity19 and wild type @entity19 were fed with a high fat diet to establish a type 2 @entity6 model. In addition, @entity1 umbilical vein endothelial cells (HUVECs) were cultured and subjected to high @entity413 /high fat (HG/HF). The @entity6198 inflammasome activation was increased in type 2 @entity6 @entity19 and treatment of @entity6 aortic segments with @entity66648 , a potent selective inhibitor of @entity6198 inflammasome ex vivo improved endothelial-dependent vasorelaxation. @entity6198 inflammasome activation and vascular endothelial injury were significantly increased in @entity30206 -KO @entity19 compared with @entity7097 @entity19 in @entity6 and MCC950 decreased @entity532 to comparable levels in @entity30206 -KO @entity19 and @entity7097 @entity19 . @entity30206 could decrease @entity6198 inflammasome activation and attenuate endothelial cell injury, which was abolished by @entity6198 inflammasome overexpression. Inhibition of @entity6710 formation preferentially attenuated @entity6198 inflammasome activation in @entity30206 -KO @entity6 @entity19 . The current study demonstrated for the first time that @entity17211 -induced @entity6198 inflammasome activation was a novel mechanism of @entity532 .

title: A novel mechanism of @entity532 : @entity17211 -induced XXXX inflammasome activation.

entities_list: @entity17211 :: ('MESH:C567258', 'Disease') :: ['hypoadiponectinemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic mellitus', 'diabetic', 'diabetes']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['diabetic vascular endothelial dysfunction']

entities_list: @entity6710 :: ('MESH:D030421', 'Chemical') :: ['peroxynitrite']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6198 :: (216799(Tax:10090),Gene) :: ['NLRP3']


abstract: The new WHO-classification of @entity703 includes new subtypes, one of which is the mucinous, tubular, and @entity189 . Many of these @entity5 had been previously diagnosed as @entity189 . There are areas of cord-like growth and spindle cell configuration, sometimes with a clear cell appearance. The cells have low-grade nuclear features. It has been postulated that these @entity5 are related to the loop of Henle. In this study, 21 @entity5 were immunohistochemically and genetically analyzed. The analysis showed complex genomic aberrations, but no chromosome 3p losses. Fluorescence in situ hybridization detected no @entity280 gene deletions on chromosome 3p25, which are characteristic for @entity1358 . These findings show that there is no genetic relationship to @entity1358 . The results of the immunohistochemical analyses showed a complex immunophenotype, but could not prove a derivation from the loop of Henle. The prognosis of these @entity5 seems to be favorable.

title: [Mucinous spindle cell XXXX . A molecular analysis].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['sarcomatoid carcinoma', 'spindle cell carcinoma']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear cell renal carcinomas']

entities_list: @entity280 :: ('MESH:D006623', 'Disease') :: ['von Hippel-Lindau']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']

answer: @entity703 :: (MESH:D007680,Disease) :: ['carcinoma of the kidney']


abstract: INTRODUCTION: Estimation of prognosis is @entity1 undergoing radical cystectomy is often unreliable, as @entity66 remains undetected by conventional diagnostic tools. The purpose of this study was to evaluate the feasibility and the clinical significance of a polymerase chain reaction assay to detect @entity5822 ( @entity5822 ) mRNA expression in peripheral blood cells of @entity1 undergoing radical cystectomy for clinically nonmetastatic @entity150 . @entity1 AND METHODS: From 2005 to 2009, 59 @entity1 undergoing radical cystectomy and pelvic lymph node dissection were prospectively investigated. Peripheral blood was collected prior to surgery, and a nested polymerase chain reaction assay was developed to identify @entity1 with circulating cells expressing @entity5822 mRNA. Preoperative, histopathologic data and clinical outcome were compared with @entity5822 findings. RESULTS: @entity5822 expression was detected in 23 (38.9%) of 59 @entity1 and correlated to T stage and lymph node status. After a median follow-up of 42 months, 29 @entity1 experienced a recurrence, whereas 36 died. The presence of @entity5822 -positive cells was significantly associated with an increased risk for recurrence and decreased survival as compared with @entity1 who were @entity5822 -negative (P  < .001 and P  < .001, respectively; hazard ratios of 8.77 and 5.2 for recurrence and @entity204 , respectively). The detection of @entity5822 -positive cells was an independent predictor of recurrence and @entity204 in a multivariable analysis. CONCLUSION: The detection of @entity5822 mRNA in the circulating cells of @entity1 undergoing radical cystectomy for @entity5 identifies those with significantly increased risk of @entity5 recurrence and @entity204 .

title: Detection and Clinical Significance of @entity5 Cells in XXXX Undergoing Radical Cystectomy for Urothelial @entity150 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['occult disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'urothelial cancer']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['overall death', 'death']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Tandem occlusive disease in the setting of acute @entity385 involving cervical and cerebral arteries has been associated with poor neurological outcome and poses significant challenges to neurointerventionists. Previously described endovascular methods typically involve carotid revascularization with stent placement prior to or following intracranial thrombectomy. Stent-based approaches, however, require the use of antiplatelet therapy which may increase the risk of hemorrhagic transformation. We describe a novel modified Dotter technique which may be used for carotid revascularization in lieu of stenting. This technique can eliminate the need for antiplatelet therapy, reduce procedure times, and possibly reduce hemorrhagic conversion rates. METHODS: Seven @entity1 presenting between April 2013 and January 2014 were treated with this technique. All @entity1 had carotid stenosis of 65-100% and tandem middle cerebral @entity432 . National Institutes of Health (NIH) @entity64 Scale scores as well as clinical and procedural times were recorded. Pre- and post-Dotter stenosis was measured using the NASCET criteria. Follow-up imaging and clinical data were reviewed. RESULTS: The mean age was 64   years and mean initial NIH @entity64 Scale score was 11.7. Mean groin to recanalization time was 26   min. Thrombolysis In Cerebral Infarction grade 2b-3 was achieved in all @entity1 . The mean stenosis was 88% preoperatively and 61% postoperatively. There were no @entity932 . The modified Rankin Scale score was 0 in six @entity1 (86%) and 6 in one @entity1 (14%). CONCLUSIONS: The @entity64 technique is a feasible and safe alternative to carotid stenting in the setting of acute @entity385 and may reduce the risk of hemorrhagic conversion. No re-occlusion occurred during follow-up in @entity1 with post-Dotter stenosis  <=65%.

title: The Dotter method revisited: early experience with a novel method of rapid internal carotid artery revascularization in the setting of acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['Dotter stroke', 'Stroke']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhages']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusions']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: Objective To improve the management of the early @entity3126 (NPE)in @entity1 with non- @entity1779 . Methods Totally 140 eligible @entity1 with non- @entity1779 who were treated in the emergency department of our hospital from October 2008 to October 2014 were divided into two groups:NPE group(n=25)and non-NPE group(n=115). The clinical data were analyzed and compared. Results Although the mean arterial pressure was similar between these two groups,the median pH and the @entity3157 ion( @entity3157 )were significantly lower in the NPE group than in the non-NPE group(pH:7.32 vs.7.39,P=0.002; @entity3157 ,20.6 mmol/L vs.22.7 mmol/L,P=0.01). Multivariate regression analysis indicated that younger age and higher @entity413 level were significantly correlated with the early onset of NPE in the NPE group than in the non-NPE group(age:50.1 years vs.65.1 years,P=0.0008; @entity413 ,15.4 mmol/L vs.10.78 mmol/L,P=0.001).There were only 3 @entity1 in all with non- @entity1779 happened the fulminant NPE in 1 hour. Within 24 hours after @entity1 visited the emergency room,the condition was improved in 20 of 25 @entity1 in the NPE group. However,5 @entity1 died,among whom 3 @entity1 with fulminant NPE(onset within 1 hour)died due to acute @entity649 and complicated with @entity881 ,and 2 died of @entity3976 . Conclusions NPE is a rare and severe complication in @entity1 with non @entity1779 . The possibility of NPE should be considered in relatively young @entity1 with higher @entity413 and lower blood pH value. Timely prevention and treatment can improve the outcomes.

title: Identification and Treatment of the Early Form of XXXX in Emergency Room.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3976 :: ('MESH:D004677', 'Disease') :: ['cerebral hernia']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['neurogenic pulmonary edema']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['HCO3(-)', 'bicarbonate']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['traumatic cerebral hemorrhage']

answer: @entity3126 :: (MESH:D011654,Disease) :: ['Neurogenic Pulmonary Edema']


abstract: OBJECTIVE: @entity13375 , a disorder of @entity78 metabolism that can result in @entity729 , skin and solid organ @entity460 deposits, and nonhealing @entity1066 , is associated with significant morbidity and mortality. Although its most common cause is @entity3528 in @entity1 with @entity177 , vascular surgeons are frequently called on to evaluate these nonhealing extremity wounds. We reviewed our experience of a multidisciplinary approach in treating @entity1 with @entity13375 and nonhealing @entity1066 . @entity1 AND METHODS: Over a 14-month period at a tertiary center, five @entity1 were seen with @entity13375 and nonhealing leg wounds. Demographics, disease characteristics, surgical treatment, and outcomes were analyzed. RESULTS: All five @entity1 were black @entity1 aged 40 +/- 8.9 years with @entity177 undergoing long-term hemodialysis (80 +/- 43 months). They had large, @entity158 (mean size, 135 cm(2)) that had developed over 2 to 4 months. Three @entity1 had palpable pedal pulses, one @entity1 had Doppler pedal signals, and one @entity1 had absent pedal flow. Arteriogram was performed in the latter two @entity1 , and one @entity1 underwent lower extremity revascularization because of superficial femoral @entity2791 with symptomatic improvement. Four @entity1 underwent @entity146 debridement by the vascular surgical service, and two needed plastic surgeon-performed skin grafting. All @entity1 had elevated parathyroid hormone levels (mean, 1735 pg/mL; > 25 x normal level); mean preoperative @entity460 levels were normal (10 mg/dL). After either subtotal (n = 4) or total (n = 1) parathyroidectomy by an experienced endocrine surgeon, a significant reduction in parathyroid hormone and @entity460 levels was seen (122 pg/mL and 7.9 mg/dL, respectively; P <.05). There were no postoperative complications or amputations; one @entity1 died 12 months after parathyroidectomy of severe preexisting @entity66 . Complete wound healing was observed by 4.8 +/- 2 months. During a mean follow-up period of 9 months (range, 1 to 18 months), all wounds remained healed without @entity1066 recurrence. CONCLUSION: The diagnosis of @entity13375 should be considered in @entity1 with @entity454 with atypical tissue @entity39 or subcutaneous nodules. Early recognition of @entity13375 and multidisciplinary treatment, including diligent wound care, frequent debridement, parathyroidectomy, and appropriate skin grafting or revascularization, can result in improved wound healing and limb salvage.

title: XXXX and nonhealing wounds: the role of the vascular surgeon in a multidisciplinary treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'women', 'patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cardiopulmonary disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcerations', 'ulcers', 'ulcer']

entities_list: @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium-phosphate']

entities_list: @entity3528 :: ('MESH:D006962', 'Disease') :: ['secondary hyperparathyroidism']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['artery stenosis']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure', 'hypertensive renal failure']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful lower extremity wounds or necrotic ulcers']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['arterial calcification']

entities_list: @entity13375 :: ('MESH:D002115', 'Disease') :: ['Calciphylaxis', 'calciphylaxis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity13375 :: (MESH:D002115,Disease) :: ['Calciphylaxis']


abstract: PURPOSE: To evaluate the effectiveness of laser-assisted angioplasty for @entity1 with @entity63 ( @entity63 ) who were poor candidates for surgical revascularization. METHODS: A prospective registry at 14 sites in the US and Germany enrolled 145 @entity1 with 155 critically ischemic limbs; the @entity1 were poor candidates for bypass surgery owing to inadequate target vessel or saphenous vein, prohibitive @entity299 , or significant comorbidities (ASA class 4). Additional comorbid risk factors included @entity6 in 66%, @entity101 in 83%, previous @entity64 in 21%, and @entity583 in 23%. Endovascular treatment included guidewire traversal and excimer laser angioplasty followed by balloon angioplasty with optional stenting. RESULTS: Occlusions were present in 92% of limbs. A mean of 2.7+/-1.4 lesions were treated per limb; the total median treatment length was 11 cm (mean 16.2, range 0.2-123). Stents were implanted in 45% of limbs. Procedural success, defined as <50% residual stenosis in all treated lesions, was seen in 86% of limbs. At 6-month follow-up, limb salvage was achieved in 110 (92%) of 119 surviving @entity1 or 118 (93%) 127 limbs. CONCLUSION: Excimer laser-assisted angioplasty for @entity63 offers high technical success and limb salvage rates in @entity1 unfit for traditional surgical revascularization.

title: Limb salvage following laser-assisted angioplasty for XXXX : results of the LACI multicenter trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia', 'CLI']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity63 :: (MESH:D007511,Disease) :: ['critical limb ischemia']


abstract: The ribs are frequently affected by blunt or penetrating @entity130 . In the emergency department setting, it is vital for the interpreting radiologist to not only identify the presence of @entity130 but also alert the clinician about organ-specific injury, specific traumatic patterns, and @entity697 that require emergent attention. @entity130 can be separated into specific morphologic @entity174 patterns that include stress, buckle, nondisplaced, displaced, segmental, and pathologic @entity174 . Specific attention is also required for flail chest and for @entity174 due to pediatric nonaccidental @entity130 . Rib @entity174 are associated with significant morbidity and mortality, both of which increase as the number of @entity174 increases. Key complications associated with rib @entity174 include @entity158 , hemothorax, pneumothorax, @entity1410 , @entity358 , @entity358 , @entity1317 , and abdominal solid-organ injury. @entity154 , including supernumerary or accessory ribs, vestigial anterior ribs, @entity17339 , and synostoses, are common and should not be confused with traumatic pathologic conditions. Nontraumatic mimics of @entity130 , with or without @entity174 , include @entity3 , primary @entity5 ( @entity421 , @entity511 , @entity2828 , @entity1222 ), @entity82 , and @entity4261 . Principles of management include supportive and procedural methods of alleviating @entity158 , treating complications, and stabilizing @entity85 . By recognizing and accurately reporting the imaging findings, the radiologist will add value to the care of @entity1 with @entity130 . Online supplemental material is available for this article. (  )RSNA, 2017.

title: XXXX : Patterns, Imaging Pitfalls, Complications, and Treatment.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['Congenital anomalies']

entities_list: @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute rib trauma complications']

entities_list: @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrous dysplasia']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fractured ribs', 'fracture']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['osseous neoplasms']

entities_list: @entity1222 :: ('MESH:D006646', 'Disease') :: ['Langerhans cell histiocytosis, and osteochondroma']

entities_list: @entity4261 :: ('MESH:D010001', 'Disease') :: ['Paget disease']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['extrapleural hematoma']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary contusion', 'pulmonary laceration']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['acute vascular injury']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['posttraumatic deformity']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['rib injuries', 'traumatic rib injury', 'Rib injuries', 'trauma', 'thoracic trauma', 'injury to the thorax']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Traumatic Rib Injury']


abstract: PURPOSE: The purpose of this study is to retrospectively analyze all pediatric @entity1 with the diagnosis of @entity816 treated either definitively or postoperatively in our department from 1978 through 1988. Grade, age, T-stage, @entity5 location, and extent of resection are individually analyzed as prognostic indicators of overall survival. MATERIALS AND METHODS: Pediatric @entity816 @entity1 (grades I-IV) diagnosed by CT-guided biopsy or surgical resection were assessed. @entity1 were treated with external beam radiotherapy to involved fields using 4- or 6-MV photons. Daily doses ranged from 1.5 to 2.0 Gy; total doses from 41.4 to 66 Gy. Treatment was given to 17 @entity1 (9 male, 8 female), aged 18 years and younger: 11 @entity1 had low-grade (I _ II) @entity816 with incomplete margins; 3 @entity1 had @entity816 ; and 3 @entity1 had @entity463 multiforme. RESULTS: Overall survival at 140 months was 63%. Median follow-up of @entity1 living NED was 69 months, with a range of 39-140 months. Nine of the eleven (82%) low-grade @entity1 survived NED; 1 of 3 anaplastic @entity1 is NED at 44 months follow-up; 1 died of intercurrent disease at 80 months; the third died of disease at 49 months. All three @entity463 succumbed to @entity66 at 9, 15, and 27 months from diagnosis. Univariate analysis showed only grade to be prognostically significant (p < .03) in determining overall survival. CONCLUSION: Postoperative radiotherapy for unresected or partially resected low-grade @entity816 produces excellent local control. Higher grade @entity816 require further investigational studies to improve survival and local control. Grade is prognostically significant with respect to overall survival.

title: XXXX . The Louisville experience: 1978-1988.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['local disease']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma', 'anaplastic astrocytoma', 'astrocytomas']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'glioblastoma']

answer: @entity816 :: (MESH:D001254,Disease) :: ['Pediatric astrocytomas']


abstract: PURPOSE: To evaluate the treatment outcomes after guided tissue regeneration (GTR) with a bioabsorbable membrane in @entity6876 in mandibular molars. The open flap debridement (OFD) was used as the control. METHODS: Nine @entity1 , with two comparable @entity6876 were included in the study. After initial preparation, the defects were randomly assigned in each @entity1 to either GTR-group or OFD-group. Clinical parameters and standardized radiographs were obtained at baseline and 6 months after the surgeries. The radiographs were analyzed by subtraction radiography. RESULTS: Comparing baseline to 6-month results, both groups showed statistically significant @entity92 ( @entity92 ), horizontal clinical attachment level (CAL-h) gain, and increase in @entity1464 ( @entity1464 ). The vertical clinical attachment level (CAL-v) gain was statistically significant only for the OFD-group. Comparing the two treatments, no statistically significant differences were found in @entity92 reduction (GTR: 1.67 mm; OFD: 2.51 mm, P = 0.26), CAL-v gain (GTR: 0.62 mm; OFD: 1.16 mm, P= 0.37), and @entity1464 increase (GTR: 1.04 mm; OFD: 1.24 mm, P = 0.31). GTR provided complete closure of the @entity6876 in two sites and superior horizontal clinical attachment level gain (GTR: 2.27 mm; OFD: 1.01 mm, P = 0.05). Subtraction radiography showed significant difference in bone height change between GTR-group and OFD-group (-0.14 mm and 0.86 mm, respectively; P = 0.028) at 6 months.

title: Clinical and radiographic evaluation of guided tissue regeneration in the treatment of XXXX . A randomized clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6876 :: ('MESH:D017823', 'Disease') :: ['Class II furcation defects', 'furcation defect']

entities_list: @entity92 :: ('MESH:D007222', 'Disease') :: ['PD', 'probing depth reduction']

entities_list: @entity1464 :: ('MESH:D005889', 'Disease') :: ['gingival recession', 'GR']

answer: @entity6876 :: (MESH:D017823,Disease) :: ['class II furcation defects']


abstract: PURPOSE: The purpose of our study was to assess the feasibility, @entity137 , and pharmacokinetics of an escalating dose of @entity1205 when administered with @entity1261 ( @entity1261 ) support every 3 weeks. EXPERIMENTAL DESIGN: @entity1 with advanced solid @entity5 were treated with escalating doses of @entity1205 as a 1-h infusion every 3 weeks, supported by s.c. administration of @entity1 recombinant glycosilated @entity1261 Granocyte (lenograstim), 5 microg/kg/day (from day 4 until neutrophil count >0.5-10(g)/liter for two consecutive days). Plasma sampling was performed to characterize the pharmacokinetics of @entity1205 at the new recommended high-dose level. RESULTS: Forty-seven @entity1 were treated with 116 courses of @entity1205 at eight dose levels ranging from 100-185 mg/m(2). Dose-limiting @entity137 were nonhematologic and included @entity33 and @entity1909 . Severe skin @entity137 observed at 185 mg/m(2) led to discontinuing the study, and 175 mg/m(2) was selected as the recommended dose of @entity1205 + @entity1261 for future Phase II studies. Analysis of multiple courses revealed @entity1909 , @entity33 , @entity4841 / @entity925 , and @entity16 as the main dose-related toxic events. At 175 mg/m(2) mean +/- SD values for @entity1205 plasmatic peak, area under the curve, clearance, volume of distribution, and terminal half-life were 6.7 +/- 1.7 microg/ml, 9.7 +/- 4 microg.h/ml, 34.2 +/- 12 liters/h, and 122.7 +/- 124 liters, respectively. Of the 16 @entity1 treated at 175 mg/m(2), 8 @entity1 responded (7 @entity0 @entity1 ) including one complete response (1 @entity0 @entity1 ). CONCLUSIONS: Using @entity1261 support allows substantial dose escalation of @entity1205 . Whether such a dose increase improves the response rate warrants further investigation. At the highest dose level studied, pharmacokinetic parameters seem to maintain a linear profile.

title: Phase I and pharmacokinetic study of escalating dose of @entity1205 administered with @entity1261 support in adult advanced solid XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer and 1 lung cancer', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumors']


abstract: OBJECTIVE: The goal of our study is to identify significant prognostic factors for a series of @entity9128 in an adult population. Age, location, histology, preoperative clinical status, extent of resection and radiotherapy were examined. METHODS: Our series includes 34 @entity1 . Ten @entity5 were located in the @entity75 , 5 in the lateral ventricle, 8 in the third and 11 in the fourth ventricle. @entity424 were grades 2 and 17 were anaplastic. Surgical resection was gross-total in 27 @entity1 and partial in 7. RESULTS: At a mean follow-up of 9 years (+/- 1 year) 16 @entity1 died and, among the 18 survivors 14 are in complete remission and 4 present a local recurrence. The 5- and 10-year overall survival rates were respectively 62% and 43%. The 5- and 10-year progression-free survivals were 47% and 43%. Univariate analysis revealed that location in the @entity75 and @entity4575 are the only statistically significant predictors of poor outcome. CONCLUSION: We can make out three groups of @entity1 from our series: the first encompasses @entity1 operated on for an @entity5 , in all our cases an @entity424 , with a 5-year rate of @entity5 -related deaths of 100%. The second group includes fourth @entity424 , which are mostly grade 2 @entity5 . They display a 10-year survival rate of 90%. Last group entails lateral and third @entity424 , of both low and high grade, with a 10-year survival rate of 60% for lateral ventricle and 35% for third @entity5 .

title: XXXX in adult @entity1 : analyses of prognostic factors.

entities_list: @entity9128 :: ('MESH:C531673', 'Disease') :: ['intracranial ependymomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity424 :: ('MESH:D004806', 'Disease') :: ['Seventeen ependymomas', 'anaplastic ependymoma', 'ventricle ependymomas']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain parenchyma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'intraparenchymal tumor', 'ventricle tumors', 'tumors']

entities_list: @entity4575 :: ('MESH:D000708', 'Disease') :: ['anaplasia']

answer: @entity9128 :: (MESH:C531673,Disease) :: ['Intracranial ependymomas']


abstract: Prenatal stress strongly affects sexual dimorphism of male @entity35 . Much less information is instead available on the effects of postnatal stress on sexual maturation during the so-called stress hyporesponsive period (SHRP). For this reason, we compared @entity2819 -treated (CS; 10 mg/kg sc, suspended in @entity5420 oil) or @entity7310 ( @entity7310 ; 5 h/day in the first week of life) with control @entity35 . Control and @entity7310 pups also received @entity5420 oil injections. The effects of these procedures on physical development (body weight and eye opening), sexual maturation [anogenital distance, testis weight, @entity1816 dehydrogenase/(Delta5-4) (3betaHSD) isomerase activity and time to testis descent] and glucocorticoid receptor (GR) immunoreactivity in the testis were examined. @entity2819 treatment significantly (P<.05) advanced testis descent and increased testis weight and 3betaHSD activity at puberty. In addition, adult CS @entity35 presented higher levels of GR immunoreactivity in testicular tubules when compared to control and @entity7310 @entity35 . No differences were found between control and @entity7310 @entity35 . On this basis, we propose that the silencing of adrenocortical function during the SHRP could be finalized to preserve sexual maturation from the influence of glucocorticoid effects. As SHRP is unique to rodents, this phenomenon could be related to their successful reproductive strategy.

title: @entity2819 administration to XXXX pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis.

entities_list: @entity1816 :: ('CHEBI:36836', 'Chemical') :: ['3beta-hydroxysteroid']

entities_list: @entity2819 :: ('MESH:D003345', 'Chemical') :: ['Corticosterone', 'corticosterone']

entities_list: @entity7310 :: ('MESH:C536469', 'Disease') :: ['MS', 'maternally separated pups']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: We report on a @entity1 with a generalized @entity272 associated with other @entity154 . At birth, the @entity1 presented as a collodion baby, with patchy erythema, generalized irregular dermal @entity194 , @entity1665 , @entity18026 , and conjunctival pannus. He also had @entity5766 , prominent nasal root, @entity2133 , @entity4239 , @entity14883 , syndactyly involving all interdigital spaces, and camptodactyly of fingers III-V. The hyperkeratotic membrane thinned progressively, leaving a mottled reticulated @entity272 , with patchy areas of yellowish @entity2117 and papyraceous areas. Hair and nails were @entity3986 . Mental development was borderline normal. The histological hallmarks of the skin manifestations combined @entity5656 and marked @entity194 of the dermis. The dermal extracellular matrix was immature, and factor XIII-a positive dendrocytes were rare and globular rather than dendritic. We frame as a hypothesis that the disease is due to or associated with a defect in maturation of a subset of dermal dendrocytes during fetal life. This entity may be designed as the @entity751 (kappaomicronrhoalphaxi:grapnel- taurhoalphachiiotatauepsilonsigma: roughness)

title: XXXX : a syndromic form of self-healing collodion baby with residual dappled @entity194 of the derma.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['minor anomalies']

entities_list: @entity18026 :: ('MESH:C563111', 'Disease') :: ['absent eyelashes and eyebrows']

entities_list: @entity4239 :: ('MESH:D008844', 'Disease') :: ['micrognathia']

entities_list: @entity5656 :: ('MESH:D017488', 'Disease') :: ['orthokeratotic hyperkeratosis']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['large mouth']

entities_list: @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['dystrophic']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['koraxitrachitic syndrome']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorder', 'skin atrophy']

entities_list: @entity5766 :: ('MESH:D006972', 'Disease') :: ['hypertelorism']

entities_list: @entity14883 :: ('MESH:D059327', 'Disease') :: ['brachydactyly']

answer: @entity751 :: (MESH:D013577,Disease) :: ['Koraxitrachitic syndrome']


abstract: BACKGROUND: @entity120 ( @entity120 ) is a life-threatening complication in @entity1 with @entity740 on hemodialysis (CKD- @entity2033 ). OBJECTIVES: To determine whether subcutaneous infusion of @entity13992 was effective and tolerable CKD- @entity120 . METHODS AND RESULTS: A 57-year-old @entity1 was admitted to our hospital due to @entity1163 and @entity1353 during exercise with a history of CKD- @entity2033 . Cardiac catheterization revealed high pulmonary arterial pressure (PAP) of 53/24/32 mmHg and @entity358 ( @entity358 ) of 11.2 w.u. Upfront combination therapy with @entity12584 and @entity7855 was started. However, 6-month therapy did not attenuate his symptoms, probably due to the high PAP and @entity358 (60/19/30 mmHg and 5.9 w.u.). We added subcutaneous @entity13992 . Surprisingly, 9-month @entity13992 (50 ng/kg/min) normalized hemodynamics (PAP: 25/4/13 mmHg and @entity358 : 1.9 w.u.). His symptoms during excise disappeared without any adverse effects. CONCLUSION: This is the first report that subcutaneous @entity13992 was very effective and tolerable in a @entity120 @entity1 with CKD- @entity2033 .

title: Subcutaneous @entity13992 was effective and tolerable in a @entity1 with severe XXXX associated with @entity740 on hemodialysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['Pulmonary hypertension', 'PH']

entities_list: @entity1163 :: ('MESH:D013575', 'Disease') :: ['presyncope']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity7855 :: ('MESH:C101426', 'Chemical') :: ['sildenafil']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['PVR', 'pulmonary vascular resistance']

entities_list: @entity13992 :: ('MESH:C427248', 'Chemical') :: ['treprostinil']

answer: @entity120 :: (MESH:D006976,Disease) :: ['pulmonary hypertension']


abstract: PURPOSE: To present ocular findings in three family members with @entity9712 ( @entity9712 ) associated with a novel @entity62889 mutation. CASES: We examined 21- (Case 1), 17- (Case 2), and 10-year-old (Case 3) male @entity1 who showed wheel-like @entity5409 in the macula and a @entity575 -gray reflex in the peripheral retina. Case 2 was a cousin of Case 1. Case 3 was a brother of Case 2. METHODS: Scotopic electroretinogram (ERG) (dim and bright flash), oscillatory potentials, photopic ERG, and 30-Hz flicker responses were recorded in each @entity1 . The @entity62890 gene was analyzed in @entity1 blood samples by a direct sequencing method. RESULTS: A novel missense mutation ( @entity62889 ) was identified in the @entity62890 gene in each @entity1 . Variable b/a ratios upon scotopic bright flash stimulation were evident (Case 1: right 1.16, left 1.20; Case 2: right 0.98, left 1.01; Case 3: right 0.81, left 0.83). Only Case 3 showed the typical "negative" waveform. The amplitude of rod b-waves was significantly decreased in all @entity1 . CONCLUSIONS: Three cases with a novel @entity62889 mutation showed the phenotypic variation in ERG, especially in b/a ratio, which has been considered an important diagnostic parameter.

title: Electroretinographic findings in three family members with @entity9712 associated with a novel @entity62889 mutation of the XXXX gene.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5409 :: ('MESH:D052177', 'Disease') :: ['cystic lesions']

entities_list: @entity9712 :: ('MESH:D041441', 'Disease') :: ['X-linked juvenile retinoschisis', 'XLRS']

entities_list: @entity62889 :: ('p|SUB|P|192|T', 'ProteinMutation') :: ['Pro192Thr']

answer: @entity62890 :: (6247,Gene) :: ['XLRS1']


abstract: Compared with @entity1053 ( @entity1053 ), @entity1 with @entity1566 ( @entity1566 ) have a 3- to 5-fold higher risk of developing @entity6 , which may be associated with increased fat mass. Evidence suggests that leptin regulates body adiposity through the sympathetic nervous system, which is impaired in @entity1 with high lesion @entity1566 . The purpose of this study was to determine the relationship among leptin levels, body composition, and resting metabolic rate (RMR) in @entity1 with high lesion @entity1566 and body mass index-, weight-, height-, and waist circumference-matched @entity1053 subjects. Fourteen subjects (seven @entity1566 and seven @entity1053 ) participated in the study. After an overnight fast, various hormones, @entity413 , and RMR were measured. There was no significant difference in plasma @entity413 , @entity2690 , GH, @entity701 , and glucagon levels between the two groups. The @entity1566 group had 105% higher plasma leptin levels than the @entity1053 group (P < 0.05). Plasma leptin levels correlated with body mass index ( @entity1566 : r = 0.80; P = 0.028; @entity1053 : r = 0.79; P = 0.035) and fat mass ( @entity1566 : r = 0.95; P = 0.001; @entity1053 : r = 78; P = 0.038) in both groups. The plasma leptin level correlated with the absolute RMR ( @entity1566 : r = 0.15; P = 0.75; @entity1053 : r = 0.99; P < 0.006) and the RMR per unit fat-free mass ( @entity1566 : r = -0.70; P < 0.08; @entity1053 : r = 0.845; P < 0.017) in the @entity1053 group, but not in the @entity1566 group. The absolute RMR was significantly reduced in the @entity1566 group compared with the @entity1053 group, but there was no difference in the relative RMR between the groups. In conclusion, the @entity1566 group has a significantly higher plasma leptin level than the @entity1053 group. The absolute and relative RMR correlated with leptin only in the @entity1053 group.

title: Intact sympathetic nervous system is required for leptin effects on resting metabolic rate in XXXX with @entity1566 .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: Normotensive hypokalaemic tubulopathies ( @entity4861 ( @entity10673 / @entity1412 )) are @entity74 that are considered benign. However, @entity1162 , @entity1002 and reduction of cardiac index upon exercise leading to @entity943 and @entity1164 have been reported in these @entity1 . Hence, we aimed to verifying whether an isometric exercise could represent a useful tool for the identification of @entity1 at risk for future @entity299 . @entity1 AND METHODS: @entity296 ( @entity296 ) and perfusion, evaluated as @entity296 ( @entity296 ) of 10 @entity10673 / @entity1412 @entity1 and 10 healthy controls, were investigated at rest and during isometric exercise. @entity296 and @entity296 were evaluated using quantitative two-dimensional and myocardial contrast echocardiography. RESULTS: @entity10673 / @entity1412 @entity1 had normal baseline @entity296 and @entity296 . During exercise in @entity10673 / @entity1412 @entity1 , corrected QT (QTc) was prolonged to peak value of 494 +/- 9.1 ms (P < 0.001). In controls, @entity296 increased from resting to peak exercise (left ventricular ejection fraction: 65 +/- 4% to 78 +/- 5%, P < 0.003) while in seven @entity10673 / @entity1412 @entity1 (Group 1) it declined (64 +/- 5% to 43 +/- 9%, P < 0.001). Myocardial perfusion increased upon exercise in controls as shown by changes of its markers: beta (a measure of myocardial flow velocity; 0.89 +/- 0.12 vs. 0.99 +/- 0.12, P < 0.001) and myocardial blood volume (14.4 +/- 2 vs. 20.2 +/- 0.25, P < 0.001), while in Group 1 @entity10673 / @entity1412 it decreased (0.87 +/- 0.15 vs. 0.67 +/- 0.15, P < 0.001; and 14.5 +/- 1.9 vs. 8.3 +/- 0.22, P < 0.001, respectively). CONCLUSIONS: Our results document for the first time that exercise induce coronary microvascular and @entity296 in @entity10673 / @entity1412 @entity1 . Therefore, this may challenge the idea that @entity10673 / @entity1412 are benign diseases. In addition, the diagnostic approach to these syndromes should include an in-depth cardiac assessment in order to identify @entity1 at higher risk.

title: Myocardial perfusion defects in XXXX .

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial function', 'MF', 'MBF', 'myocardial defects', 'myocardial blood flow']

entities_list: @entity4861 :: ('MESH:D053579', 'Disease') :: ['Bartter and Gitelman syndromes']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic diseases']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['QT prolongation']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']

answer: @entity4861 :: (MESH:D053579,Disease) :: ['Bartter and Gitelman syndromes']


abstract: BACKGROUND: There is growing evidence that @entity1 diagnosed with @entity5 can experience @entity1004 ( @entity1004 ). This combined experience of @entity5 and abuse can have a profound effect on health and treatment outcomes for these @entity5 survivors. OBJECTIVE: The purpose of this literature review was to assess the presence of @entity1004 among female @entity5 survivors and to provide oncology nurses with clinical guidelines about @entity1004 . METHODS: A systematic strategy was used to locate original research from 4 databases: CINAHL, PubMed, PsycINFO, and Web of Science. Key words were used to help identify articles that focused on @entity5 , abuse, treatment decision making, and clinical guidelines. RESULTS: The 10 selected articles that met the inclusion criteria were published between 2005 and 2014. The reviewed studies provided accounts of abusive partner behaviors toward @entity1 throughout their @entity5 trajectory. Global organizations provided the framework for clinical guidelines. CONCLUSIONS: Challenges faced by @entity1 who are concurrently living with @entity1004 and @entity5 survivorship can impact treatment decision making and health outcomes. The assessment and recognition of @entity1004 by oncology nurses are essential to help create a clinical environment in which @entity1 feel safe and supported. IMPLICATIONS FOR PRACTICE: This review includes clinical guidelines and describes legal considerations for oncology nurses to consider when they address and respond to @entity1004 in their practice. The use of clinical guidelines that focus on @entity1004 can provide standardized care in the oncology setting that can further help to meet the needs of these @entity1 .

title: Intimate Partner Violence Among XXXX Diagnosed With @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity1004 :: ('MESH:C563733', 'Disease') :: ['IPV', 'intimate partner violence']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: UNASSIGNED: @entity82 is a major cause of progressive @entity881 in several chronic @entity358 . Rho associated coiled-coil forming kinase (ROCK) has shown to be involved in myofibroblast differentiation driven by altered matrix stiffness in fibrotic state. There are two known ROCK isoforms in @entity1 , @entity9067 (ROKb) and @entity23759 (ROKa), but specific role of each isoform in myofibroblast differentiation in @entity82 remains unknown. To study this, we developed a Gelatin methacryloyl (GelMA) hydrogel based culture system with different stiffness levels relevant to healthy and fibrotic lungs. We have shown that stiff matrix and not soft matrix, can induce myofibroblast differentiation with high @entity1970 expression. Furthermore, our data confirm that the inhibition of ROCK signalling by a pharmacological inhibitor (i.e. @entity12223 ) attenuates stiffness induced @entity1970 expression and fibre assembly in myofibroblasts. To assess the role of ROCK isoforms in this process we used siRNA to knock down the expression of each isoform. Our data showed that knocking down either @entity9067 or @entity23759 did not result in a reduction in @entity1970 expression in myofibroblasts on stiff matrix as opposed to soft matrix where @entity1970 expression was reduced significantly. Paradoxically, on stiff matrix, the absence of one isoform (particularly @entity23759 ) exaggerated @entity1970 expression and led to thick fibre assembly. Moreover complete loss of @entity1970 fibre assembly was seen only in the absence of both ROCK isoforms suggesting that both isoforms are implicated in this process. Overall our results indicate the differential role of ROCK isoforms in myofibroblast differentiation on soft and stiff matrices.

title: Role of ROCK Isoforms in Regulation of Stiffness Induced Myofibroblast Differentiation in Lung XXXX .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['lung fibrosis', 'Fibrosis']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary diseases']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction']

answer: @entity82 :: (MESH:D005355,Disease) :: ['Fibrosis']


abstract: BACKGROUND: Despite the well-documented importance of the psycho-emotional status in modulating the anticancer immunity, at present no study has been performed to analyse the influence of the @entity558 on the efficacy of @entity1199 @entity5 immunotherapy. Previous clinical studies have already suggested that the evidence of @entity148 may negatively affect the therapeutic efficacy of @entity1199 immunotherapy of @entity5 . Moreover, previous psycho-oncological investigations showed that the suppression of sexual pleasure and sexual identity would represent one of the most frequent psychological profiles in @entity5 @entity1 . On this basis, a study was planned in an attempt to evaluate relations existing between psychological status, analysed using the Rorschach test and efficacy of @entity1199 immunotherapy in the treatment of metastatic @entity1358 @entity1 . @entity1 AND METHODS: The study included 30 consecutive metastatic @entity1358 @entity1 . @entity1199 was injected s.c. at a dose of 3 million IU twice/day 5 days/week for 4 consecutive weeks, corresponding to one complete immunotherapeutic cycle, followed by a second cycle after a 21-day rest period. RESULTS: A complete response (CR) was achieved in only 1/30 (3%) @entity1 ; a partial response (PR) was obtained in 6/30 (20%) @entity1 . The @entity5 response rate (CR +PR) was 7/30 (23%) @entity1 . The performance of a psychological analysis was accepted by 24/30 (80%) @entity1 . A normal sexual identity was present in 7/24 (29%) @entity1 . The @entity5 response rate achieved in @entity1 with sexual identity was significantly higher compared to these who had no sexual identity or who refused the psychological investigation (p<0.05 and p<0.01, respectively). In the same way, the increase in mean lymphocyte number obtained in @entity1 with sexual identity was significantly higher compared to that found in the other two groups of @entity1 . CONCLUSION: This study demonstrated that the psychological status prior to treatment may be associated with the clinical response to @entity1199 @entity5 immunotherapy.

title: Efficacy of XXXX immunotherapy in @entity1358 in relation to the psychic profile as evaluated using the Rorschach test.

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['psychological condition']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell cancer', 'RCC']

answer: @entity1199 :: (3558,Gene) :: ['IL-2']


abstract: CONTEXT/OBJECTIVE: Locally aggressive @entity977 (LAPT) and @entity977 respond poorly to conventional therapy and cytotoxic drugs. Temozolomide (TMZ) is an oral alkylating drug with good tolerability, approved for treatment of @entity11 . The experience of its use in @entity977 is limited. DESIGN AND SETTING: We report on 24 @entity1 with aggressive @entity977 (16 LAPTs, 8 @entity189 ) treated with TMZ for a median of 6 months (range 1-23). Follow-up ranged from 4 to 91 months with a median of 32.5 months. 19/24 @entity5 were hormone secreting (PRL 9, ACTH 4, GH 4, GH/ @entity43545 ). Ki-67 was 2-50% in LAPTs, and 5-80% in @entity189 . MAIN OUTCOME: Response to TMZ and the association with @entity5 expression of @entity8724 ( @entity8724 ), @entity6756 , @entity4311 , and @entity4638 , examined by immunohistochemistry. RESULTS: Complete @entity5 regression occurred in two @entity189 and persisted at follow-up after 48 and 91 months, respectively. Partial regress of @entity5 mass ranging from 35% to 80% occurred in 5 LAPTs and 2 @entity189 . Another @entity1 with LAPT had a 71% decrease in prolactin levels without change in @entity5 volume. Three LAPTs could not be evaluated. Median @entity8724 staining was 9% (5-20%) in responders vs 93% (50-100%) in nonresponders. Loss of @entity4311 and @entity4638 was observed in a single @entity1 who had a rapid development of resistance to TMZ. CONCLUSIONS: This study shows that TMZ is a valuable treatment option for @entity1 with uncontrolled @entity977 . The data suggest that tumoral @entity8724 staining below 50% is associated with a high likelihood of treatment response.

title: Long-Term Outcome and @entity8724 as a Predictive Marker in 24 @entity1 With @entity977 and XXXX Given Treatment With Temozolomide.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant gliomas']

entities_list: @entity8724 :: ('4255', 'Gene') :: ['MGMT', 'O6-methylguanine DNA methyltransferase']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary carcinomas', 'pituitary tumors']

answer: @entity977 :: (MESH:D010911,Disease) :: ['Pituitary Carcinomas']


abstract: @entity2407 ( @entity2407 ) is characterized by intense @entity3120 resulting in finger blanching. Treatment primarily involves vasodilation. @entity2404 (TXA2) has been shown to be a potent vasoconstrictor and platelet aggregant. It may be possible to produce a vasodilatory and anti- @entity715 effect by blockade of the TXA2 receptors. @entity47690 is a potent TXA2 receptor antagonist and we studied its effects on @entity1423 and digital blood flow in @entity1 with @entity2407 . Sixteen @entity1 with @entity2407 completed this double-blind, randomized, placebo controlled study. Each @entity1 was seen on three separate occasions and was given @entity47690 (100 mg orally) on one occasion and matching placebo tablets on the other two. We measured @entity1423 using platelet rich plasma (PRP) stimulated by @entity2872 , a @entity2871 (TX) mimetic. The concentration of @entity2872 required to cause just over 50% @entity1423 before the administration of either @entity47690 or placebo (pre-dose) was noted. The same concentration of @entity2872 was used to stimulate the PRP sample at 1 h after the administration of @entity47690 or placebo (post-dose) and the percentage of @entity1423 was again noted. Fingertip skin blood flow was also measured 1.25 h post-dose using a laser Doppler flowmeter. @entity1 were seated in a temperature controlled chamber which was initially heated to 40 degrees C to induce centrally mediated vasodilatation. The temperature was then lowered to 12 degrees C followed by rewarming to 40 degrees C. Steady blood flow values at these temperatures were measured and the rates of cooling and rewarming were also noted.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The effects of @entity2871 receptor blockade on @entity1423 and digital skin blood flow in @entity1 with secondary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane']

entities_list: @entity3120 :: ('MESH:D009383', 'Disease') :: ['blood vessel spasm']

entities_list: @entity2404 :: ('MESH:D013928', 'Chemical') :: ['Thromboxane A2']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity2407 :: ('MESH:D011928', 'Disease') :: ["Raynaud's syndrome", 'RS']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

answer: @entity2407 :: (MESH:D011928,Disease) :: ['Raynaud's syndrome']


abstract: The effects of mono, duple and triple treatment with @entity2390 , galanin and @entity750 on a @entity1 @entity694 cell line (SW 620) were investigated. The @entity5 cells were exposed to a dose corresponding to 20 microg/kg body weight/day, and to 50 and 25% of this dose (0.2, 0.1 and 0.05 microg/ml). The cells were observed at the intervals: 3, 6, 12, 24 and 48 h. @entity98 -assay was used to determine numbers of viable cells. Proliferation and apoptosis were detected by immunocytochemistry using the avidin- @entity1885 complex (ABC) method. The antibodies used were anti-Ki-67, anti- @entity12874 polymerase ' @entity12982 and anti- @entity1836 . Proliferative and apoptotic indices were determined by computerized image analysis. Almost all the mono and duple treatments of the bioactive substances succeeded in reducing the numbers of viable cells. With triple treatment, however, this decrease was greater and was evident at all observation times. The effect on proliferation varied between none, and an enhancing or inhibiting action, depending on the dose, combination and observation time. The effect on apoptosis of mono or duple exposure to the bioactive gut substances varies, depending on the concentration, combination and observation time. Triple combination at the effective dose increased the apoptotic index, with the two markers used, and appeared after 6 h, extending up to 48 h. The reduction in the number of viable @entity5 cells was greater and occurred earlier than the increase in apoptosis and was observed whether the bioactive substances were used alone or in combinations and at different concentrations. It is therefore conceivable that some other mechanism(s) than apoptosis is involved which inhibits @entity5 cell respiration. It is possible that some of the dramatic in vivo changes seen earlier, following triple treatment with @entity2390 , @entity16424 and @entity750 , may have been direct effects of these substances on @entity5 cells.

title: Direct effects of @entity2390 , galanin and @entity750 on @entity1 XXXX cells.

entities_list: @entity12874 :: ('MESH:D011064', 'Chemical') :: ['poly (ADP-ribose)']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: OBJECTIVES: The goal of this paper is to describe prehospital status and treatment of @entity1 with severe @entity131 in Austria. @entity1 AND METHODS: Data sets from 396 @entity1 with severe @entity131 (Glasgow @entity772 Scale score < 9) included by 5 Austrian hospitals were available. The analysis focused on incidence and/or degree of severity of typical clinical signs, frequency of use of different management options, and association with outcomes for both. ICU mortality, 90-day mortality, final outcome (favorable = good recovery or moderate disability; unfavorable = severe disability, vegetative state, or @entity204 ) after 6 or 12 months, and ratio of observed (90-day) to predicted mortality (O/E ratio) are reported for the selected parameters. Chi2 -test, t-test, Fisher's exact test, and logistic regression were used to identify significant (p < 0.05) differences for association with survival and favorable outcome (both coded as 1). RESULTS: The majority of @entity1 were male (72%), mean age was 49 +/- 21 years, mean injury severity score (ISS) was 27 +/- 17, mean first GCS score was 5.6 +/- 2.9, and expected hospital survival was 63 +/- 30%. ICU mortality was 32%, 90-day mortality was 37%, and final outcome was favorable in 35%, unfavorable in 53%, unknown in 12%. We found that age > 60 years, ISS > 50 points, GCS score < 4, bilateral changes in pupil size and reactivity, respiratory rate < 10/min, systolic blood pressure (SBP) < 90 mm Hg, and heart rate < 60/min were associated with significantly higher ICU and 90-day mortality rates, and lower rates of favorable outcome. With regard to prognostic value the GCS motor response score is identical to the full GCS score. Administration of > 1000 ml of fluid and helicopter transport were associated with better outcomes than expected, while endotracheal intubation in the field had neither a positive nor a negative effect on outcomes. Administration of no or < 500 ml of fluids was associated with worse outcomes than expected. Outcomes were better than expected in the few @entity1 (5%) who received hypertonic saline. CONCLUSIONS: Age, ISS, and initial neuro status are the factors most closely associated with outcome. @entity551 must be avoided. Fluids should be given to restore and/or maintain SBP > 110 mm Hg. Helicopter transport should be arranged for more seriously injured @entity1 .

title: Severe XXXX in Austria III: prehospital status and treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: OBJECTIVE: To determine the impact of @entity751 on quality of life in polio survivors. METHODS: Forty polio survivors were included in the study. Twenty-one @entity1 fulfilling the Halstead's @entity751 criteria participated in @entity751 group. The remaining nineteen @entity1 formed @entity8468 group. Control group was composed of forty healthy subjects. Quality of life was evaluated by Nottingham Health Profile, @entity308 by Beck Depression Scale and @entity1295 by Fatigue Symptom Inventory. Isometric muscle strength was measured by manual muscle testing. RESULTS: Total manual muscle testing score was 26.19  13.24 (median: 29) in @entity751 group and 30.08  8.9 (median: 32) in @entity8468 group. Total manual muscle testing scores of @entity8468 group were significantly higher than that of @entity751 group. @entity1 with @entity751 reported significantly higher levels of @entity1295 and reduced quality of life in terms of physical mobility, @entity158 and energy when compared with @entity1 without @entity751 and control group. It was not reported a statistically significant difference in social and emotional functioning and sleep quality between @entity751 , @entity8468 and control groups. Also it was not found any statistically significant difference in Beck Depression Scale scores among the groups. CONCLUSIONS: @entity751 has a negative impact on quality of life in terms of functional status, severity of @entity158 and energy. The identification, early recognition and rehabilitation of @entity751 @entity1 may result in an improvement in their quality of life.

title: Health related quality of life in Turkish polio survivors: impact of post-polio on the health related quality of life in terms of functional status, severity of @entity158 , XXXX , and social, and emotional functioning.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity8468 :: ('OMIM:600791', 'Disease') :: ['non-postpolio-syndrome']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['Postpolio-syndrome', 'postpolio-syndrome']

answer: @entity1295 :: (MESH:D005221,Disease) :: ['fatigue']


abstract: BACKGROUND: @entity230 when left on the skin for longer duration may contribute to the side effects without any additional clinical benefit. The relationship between the duration of topical @entity134 contact with the skin and its effectiveness has not been established. The ability of the topical @entity230 to inhibit the size of @entity112 induced wheal was used to assess their relative efficacy. AIM: To determine whether half an hour contact and three hour contact of a topical @entity134 , @entity6914 , is equally effective in inhibiting the size of the @entity112 induced wheal. METHODS: On 30 volunteers, 4 squares were marked on flexor aspect of both forearms using a template. One fingertip unit of @entity6914 0.05% was applied on all the areas. Half an hour later all areas of left forearm and last square of right forearm were wiped. Prick testing was done with @entity112 and size of wheal recorded after 15 minutes. Similarly @entity134 was wiped from the 1st, 2nd, 3rd square after 1 hr, 2 hr and 3 hrs on right forearm and the corresponding areas prick tested on both forearms. RESULTS: There was statistically significant wheal suppression at the end of 2 hrs and 3 hrs as compared to half an hour. CONCLUSION: We conclude that half an hour application of @entity6914 is ineffective and that it is effective only after two hours of contact and hence short contact of half an hour will be less effective than relatively prolonged contact of 2 hours.

title: Half an hour versus three hour contact of topical @entity134 ( XXXX ).

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids', 'steroids']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity6914 :: ('MESH:D002990', 'Chemical') :: ['clobetasol propionate']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

answer: @entity6914 :: (MESH:D002990,Chemical) :: ['clobetasol propionate']


abstract: Neisseria weaveri (formerly CDC [Centers for Disease Control and Prevention] group M-5 is part of the normal @entity235 oral flora. Infections in @entity1 are usually associated with @entity235 bite wounds. Very rarely the organism has been isolated from sites other than wounds, or from deep seated infections. A 60-year-old @entity1 was admitted to our hospital because of an acute exacerbation of his bronchiectasis. Gram stain of bronchial washings and expectorated sputum showed numerous polymorphs and Gram-negative bacilli. Routine bacterial culture yielded a heavy pure growth of a Gram-negative rod-shaped organism that was strongly oxidase and catalase positive, @entity104 negative, non-motile and did not ferment @entity3363 . The organism was identified as N. weaveri by using 16S rRNA sequencing. The @entity1 was treated with a 3 weeks course of @entity800 and had a good response. Sputum culture after treatment yielded normal respiratory flora only. To our knowledge, this is the first reported case of lower respiratory tract @entity281 caused by N. weaveri.

title: A case of lower respiratory tract XXXX caused by Neisseria weaveri and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patient', 'man']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity800 :: ('MESH:D015242', 'Chemical') :: ['ofloxacin']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infection']


abstract: BACKGROUND: Patency of the revascularization conduit is an essential predictor of long-standing survival after coronary artery bypass grafting. OBJECTIVES: We have conducted this study to compare the mid-term patency rates of @entity432 ( @entity432 ), @entity3538 ( @entity3538 ) and also saphenous vein (SV) grafts in asymptomatic @entity1 following coronary artery bypass graft surgery (CABG) undergoing total IV anesthesia. @entity1 AND METHODS: In this study, 30 three-vessel disease @entity1 with 104 @entity432 , @entity3538 , and SV grafts used concomitantly for primary isolated non-emergent CABG surgery were assessed. The primary end point was CT angiographic graft patency rate. After 53.5 (24-97) months' follow-up, graft patency was assessed using 128-slice CT coronary angiography. Logistic regression analysis was used to detect the independent predictors of graft failure. RESULTS: A total of 104 grafts, including 30 @entity3538 , 44 SV, and 30 @entity432 grafts, were studied. Cumulative graft patency rates were 93.3% in @entity3538 , 83.3% in @entity432 , and 70.5% in SV grafts. Statistically significant difference was found between the @entity3538 and the SV graft patency rates (P = 0.019), whereas the difference between the @entity432 conduit patency and the @entity3538 or SV graft patency rates did not have any statistical significance (P = 0.424 and P = 0.273, respectively). Independent predictors of @entity432 grafts occlusion were native coronary stenosis < 70% and female gender. CONCLUSIONS: In our @entity1 , the @entity432 grafts had an acceptable patency rate in 2 to 5 years' follow-up. Although the SV grafts had a relatively higher patency rate than @entity432 grafts in our asymptomatic @entity1 , the patency rates in @entity432 and SV grafts were close to each other. The @entity432 graft function was poor in the @entity1 with a higher number of risk factors and in the females.

title: Mid-Term Patency in Radial Artery and Saphenous Vein After Coronary Artery Bypass Grafting in Asymptomatic XXXX Using 128-Slice CT Coronary Angiography.

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['RA', 'radial artery']

entities_list: @entity3538 :: ('MESH:D002341', 'Disease') :: ['LITA', 'left internal thoracic artery']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Computerized tomography (CT) of the brain was performed in 10 of 11 consecutive @entity1 with @entity8314 ( @entity8314 ) (five @entity1 and six @entity1 ). Ten of the 11 @entity1 had brain neurosonography. Nine of 10 @entity1 had abnormal CT scans. There was diffuse, markedly reduced attenuation of the cerebral white matter in four @entity1 studied in the first week of life, and also in an @entity1 5 weeks of age. @entity62 was observed in another 5-week-old @entity1 . @entity15206 were present in two @entity1 at 2 months of age, one of whom also had mild @entity1276 . A @entity1 with @entity4651 studied at 4 months of age had enlarged ventricles and subarachnoid spaces consistent with benign @entity4651 of infancy. Cerebral ultrasound examination was abnormal in all five @entity1 studied in the first week of life and in one @entity1 at 2 months of age. Findings included @entity45 (4), echogenic white matter (3), and echogenic lenticulostriate vessels (3). Apart from one case of @entity4651 , there was no clinical evidence of @entity16 and the subsequent development of these @entity1 has been normal. Subclinical central nervous system (CNS) disease in @entity8314 is likely to be a transient phenomenon that resolves as maternal antibodies are cleared from the @entity1 's circulation. It is important to be aware of these @entity854 to avoid misdiagnosis of congenital @entity1800 in a newborn with multisystem @entity8314 . The potential for neurologic sequelae is uncertain.

title: Central nervous system involvement in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'infants', 'girls', 'boys', 'infant']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['ventriculomegaly']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disease']

entities_list: @entity8314 :: ('MESH:C536397', 'Disease') :: ['neonatal lupus erythematosus', 'NLE']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['neuroimaging abnormalities']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['subependymal cysts']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['Patchy reduced subcortical white matter attenuation']

entities_list: @entity4651 :: ('MESH:D058627', 'Disease') :: ['macrocephaly']

entities_list: @entity15206 :: ('MESH:C535607', 'Disease') :: ['Basal ganglia calcifications']

answer: @entity8314 :: (MESH:C536397,Disease) :: ['neonatal lupus erythematosus']


abstract: PURPOSE: We assessed the use of a customized, one-page structure + function report for aiding in detection of @entity16 . METHODS: Two individuals (report specialists), experienced in analyzing optical coherent tomography (OCT) and @entity227 ( @entity227 ) results, examined a customized one-page report for 50 eyes from 50 @entity1 who either had @entity726 or were @entity726 suspects. The report contained key features of OCT scans with @entity227 information. All @entity1 had 24-2 VFs with a @entity5494 ( @entity5494 ) better than -6 dB. The report specialists classified each hemifield and eye as either glaucomatous or nonglaucomatous based upon only the customized report, either without (phase 1) or with (phase 2) 24-2 @entity227 information included on the report. Their results were compared to the classifications made by 3 ophthalmologists ( @entity726 specialists) based upon traditional measures, namely stereo photographs, 24-2 VFs, and a commercially available, OCT disc scan report. RESULTS: The two report specialists agreed on all but one eye and four hemifields in phase 1, and on all eyes and all but one hemifield in phase 2. In phase 2, they judged 31 eyes abnormal. Of these 31 eyes, 30 were judged abnormal by all three @entity726 specialists and the 31st by two of the three. Without the @entity227 information (phase 1), one report specialist classified 1, and the other 2, of these 31 "abnormal" eyes as normal. CONCLUSIONS: When using the one-page report, the experienced readers showed excellent inter-rater repeatability and diagnostic ability relative to @entity726 specialists. TRANSLATIONAL RELEVANCE: This condensed report may help the clinician assess @entity16 .

title: Evaluation of a One-Page Report to Aid in Detecting XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field', 'VF']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['MD', 'mean deviation']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['glaucomatous damage']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity16 :: (MESH:D009422,Disease) :: ['Glaucomatous Damage']


abstract: OBJECTIVES: To determine the adjunctive effect of grafting biomaterials/biological agents with open flap debridement (OFD) in the treatment of @entity427 . BACKGROUND: No systematic review of treatment outcomes in @entity1 who received graft biomaterials or biological agents have been published. METHODS: A rigorous systematic review of randomized controlled trials of at least 6-month duration was conducted comparing grafting biomaterials/biological agents (alone or in combination) + OFD (test group) to OFD alone or in combination with a placebo (control group). RESULTS: The difference in CAL change between test and control groups varied from -1.45 mm to 1.40 mm with respect to different biomaterials/biological agents. Meta-analysis showed that CAL change significantly improved after treatment for coralline @entity4959 (weighted mean difference 0.90 mm; 95% CI: 0.53-1.27), bioactive glass (weighted mean difference 1.04 mm; 95% CI: 0.31-1.76), @entity692 (weighted mean difference 1.40 mm, 95% CI 0.64-2.16), and enamel matrix proteins (weighted mean difference 1.33 mm, 95% CI 0.78-1.88). However, heterogeneity in results between studies was highly statistically significant for most of biomaterials/biologicals and could not be fully explained. CONCLUSIONS: Overall, the use of specific biomaterials/biologicals was more effective than OFD in improving attachment levels in @entity154 . Difference in CAL gain varied greatly with respect to different biomaterial/biological agent. Due to a significant heterogeneity in results between studies in most treatment groups, general conclusions about the expected clinical benefit of graft biomaterials/biologicals need to be interpreted with caution. Further research should focus on understanding this variability.

title: A systematic review of graft materials and biological agents for periodontal XXXX .

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['intraosseous defects']

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite']

entities_list: @entity4959 :: ('MESH:D002119', 'Chemical') :: ['calcium carbonate']

entities_list: @entity427 :: ('MESH:D012021', 'Disease') :: ['deep intraosseous defects']

answer: @entity154 :: (MESH:D000013,Disease) :: ['intraosseous defects']


abstract: BACKGROUND: @entity1252 ( @entity1252 ) is a subtype of @entity3830 ( @entity3830 ) that has been well characterized in recent years. However, some controversy still remains concerning the histological features of epidermal involvement. OBJECTIVES: The objective of this report is to describe the clinical and microscopic features of @entity1252 in @entity1 diagnosed at Hospital Universitari Germans Trias i Pujol, Spain. METHODS: We conducted a retrospective study of 25 @entity1 with a diagnosis of @entity1252 . RESULTS: All @entity1 presented with typical @entity1252 (smooth, @entity527 without macroscopic epidermal changes, such as follicular plugs or scale, that resolved without residual scarring or @entity4182 ). None of the @entity1 fulfilled the criteria for @entity1252 during follow-up. Test results for antinuclear antibodies were positive in five @entity1 (20%), with titres below one of 320 in all cases. Twenty-two @entity1 (88%) required antimalarial therapy; response was good in 70% and moderate response in 30%. Minor epidermal alterations were observed in 52% of biopsy specimens, with focal basal vacuolization being the most frequent. CONCLUSIONS: @entity1252 is a variant of @entity3830 that has distinctive clinical, histologic and prognostic features. Unlike the @entity1 in the case series previously described in the literature, most of our @entity1 required treatment with antimalarials. Histology revealed mild epidermal alterations in a significant percentage of @entity1 . Thus, in our opinion, the absence of microscopic epidermal alterations is not constant in @entity1252 .

title: XXXX : a clinical and histological study of 25 cases.

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['erythematous plaques']

entities_list: @entity4182 :: ('MESH:D017496', 'Disease') :: ['hypopigmentation']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['Lupus erythematosus tumidus', 'LET lesions', 'systemic lupus erythematosus', 'LET']

entities_list: @entity3830 :: ('MESH:D008178', 'Disease') :: ['cutaneous lupus erythematosus', 'CLE']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['Lupus erythematosus tumidus']


abstract: The p16-cyclinD1/ @entity8985 - @entity996 pathway ( @entity995 pathway) and @entity66751 - @entity876 pathway ( @entity876 pathway) work at the G1-S checkpoint, and the ATM- @entity9516 - @entity10609 - @entity8189 / @entity10610 pathway works at the G2-M checkpoint. The disruption of these pathways is thought to be related to the prognosis of @entity1 @entity5 . In this study, we analyzed the status of these pathways in 107 @entity43 ( @entity43 ) @entity1 by immunohistochemistry and evaluated the relationship of these results with chemotherapy response and the prognosis. Altered @entity995 , @entity876 , and G2 pathways were detected in 50.5% (54/107), 51.4% (55/107), and 33.6% (36/107) of cases, respectively. The @entity1349 ( @entity1349 ) of 77.3% for @entity1 with a normal @entity995 pathway was significantly higher than the @entity1349 of 50.0% for @entity1 with an altered @entity995 pathway (by Kaplan-Meier analysis, P = 0.0021). The @entity1349 of 66.2% for @entity1 with a normal G2 pathway was significantly higher than the @entity1349 of 58.3% for @entity1 with an altered G2 pathway (P = 0.0416). However, the status of the @entity876 pathway was not related to @entity1349 . By univariate and multivariate analyses, advanced stage, high histological grade, altered @entity995 pathway, and altered G2 pathway were significant predictors of poor @entity1349 . However, there was no significant relationship between pathway status and chemotherapy response. The status of the @entity995 pathway and of the G2 pathway were independent prognostic factors of @entity43 .

title: Alteration of cell cycle regulators correlates with survival in @entity43 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity356 ( @entity356 ) is a major cause of global @entity5 mortality. Previous genomic studies have reported that several RTK-RAS pathway components are amplified in @entity356 , with @entity5 often amplifying one component and not others ("mutual exclusivity"). Here, we sought to validate these findings for three RTK/RAS components ( @entity7991 , @entity1722 , @entity984 ) using fluorescence in situ hybridisation (FISH) on a series of @entity5 , cell lines and @entity1 -derived xenografts. Applying dual-colour FISH on 137 @entity5 (89 FFPE surgical resections and 48 diagnostic biopsies), we observed @entity7991 amplification in 7.3% and @entity1722 amplification in 2.2% of GCs. GCs exhibiting @entity7991 amplification were associated with high @entity5 grade (p   =   0.034). In FISH positive @entity5 , striking differences in copy number levels between @entity5 cells in the same @entity5 were observed, suggesting @entity5 heterogeneity. Using a multicolour FISH assay allowing simultaneous detection of @entity7991 , @entity1722 , and @entity984 amplifications, we confirmed that these components exhibited a mutually exclusive pattern of gene amplification across @entity1 . The FISH data were also strongly correlated with Q-PCR levels and at the protein level by immunohistochemistry. Our data confirm that RTK/RAS components are mutually exclusively amplified in @entity356 , and demonstrate the feasibility of identifying multiple aneuploidies using a single FISH assay. Application of this assay to @entity356 samples, particularly diagnostic biopsies, may facilitate enrollment of @entity356 @entity1 into clinical trials evaluating RTK/RAS directed therapies. However, the presence of @entity5 heterogeneity may require multiple biopsy samples to be obtained per @entity1 before a definitive diagnosis can be attained.

title: Mutually exclusive @entity7991 , XXXX , and @entity984 gene amplifications in @entity356 revealed by multicolour FISH.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'gastric tumours', 'cancer', 'individual tumours', 'intra-tumour', 'tumours']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['Gastric cancer', 'GC']

answer: @entity1722 :: (2064,Gene) :: ['HER2']


abstract: BACKGROUND: In vitro studies suggest that the signal transducer and activator of transcription (STAT) plays a critical role in renal @entity82 . However, the process of STAT activation in vivo remains unclear. This study in @entity35 aimed to localize @entity12001 activation within the kidney and examine the in vivo relationship between @entity12001 activation and renal @entity82 . METHODS: @entity1695 ( @entity1695 ) was induced in the @entity35 and the kidneys examined 3 or 7 days after obstruction. Activation of @entity12001 in western blot and immunohistochemical analyses was identified by the phosphorylated form of @entity12001 (pSTAT3). RESULTS: Myofibroblasts were identified by @entity1918 expression and were upregulated in obstructed kidneys. pSTAT3 was localized mainly in tubular epithelial cells of collecting ducts in normal and obstructed kidneys and interstitial cells in obstructed kidneys. After @entity1695 , western blotting showed a fourfold increase in pSTAT3, with a peak at day 7. Immunostaining showed a sixfold increase in pSTAT3 at day 7 in tubular epithelial cells and a 2500-fold increase at day 7 in interstitial cells. CONCLUSION: @entity12001 was activated in @entity35 tubular epithelial cells and myofibroblasts after @entity1695 , suggesting that @entity12001 may contribute to the progression of @entity82 .

title: Signal transducer and activator of transcription 3 involvement in the development of renal interstitial fibrosis after unilateral XXXX .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis', 'fibrosis']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['Unilateral ureteral obstruction', 'UUO']

entities_list: @entity1918 :: ('25365(Tax:10116)', 'Gene') :: ['alpha-smooth muscle actin']

answer: @entity1695 :: (MESH:D014517,Disease) :: ['ureteral obstruction']


abstract: @entity460 signalling is involved in myriad cellular processes such as mating morphogenesis. Mating in @entity375 induces changes in cell morphology with a concomitant increase in @entity460 uptake that is dependent on the @entity17125 and @entity17124 genes. @entity17125 and @entity17124 are believed to function in a capacitive @entity460 entry (CCE)-like process. @entity2643 alters @entity1 @entity460 channel activity but, despite its clinical importance, its molecular mechanisms are not clearly defined. We have shown previously that @entity2643 has fungicidal activity against a broad array of fungi. We show here that @entity2643 causes a dramatic increase in cytoplasmic @entity460 ([ @entity141 ]cyt) in @entity375 . The majority of this increase is dependent on extracellular @entity141 nonetheless, a significant increase in [ @entity141 ]cyt is still induced by @entity2643 when no uptake of extracellular @entity141 can occur. The influx of extracellular @entity141 may be a direct effect of @entity2643 on a membrane transporter or may be by a CCE mechanism. Uptake of the extracellular @entity141 is inhibited by @entity5834 and reduced in strains deleted for the @entity17125 gene, but not in cells deleted for @entity17124 . Our data are the first demonstrating control of @entity375 @entity460 channels by @entity2643 and @entity5834 .

title: @entity2643 induces a @entity5834 -inhibited, @entity17125 -depedent rise in free cytoplasmic @entity460 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone', 'Amiodarone']

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium']

entities_list: @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['Saccharomyces cerevisiae']


abstract: PURPOSE: To determine the technical efficacy and safety of a flared @entity2636 -covered self-expandable @entity5648 stent in the management of @entity5 and to evaluate its clinical efficacy by estimating stent patency and @entity1 survival rates. MATERIALS AND METHODS: Thirteen @entity1 with common bile duct strictures (nonhilar) caused by @entity5 were treated by placement of 13 @entity5648 stents. The stents used include a flared section in the proximal portion (12 mm in diameter and 10 mm in length) and a section in the remnant portion that is fully covered with high-elasticity @entity2636 , with an unconstrained diameter of 10 mm and a total length of 50-80 mm. @entity1 survival and stent patency rates were calculated with use of Kaplan-Meier survival analysis. The follow-up @entity648 and serum amylase and lipase levels were calculated, and the differences in means were evaluated with use of a Wilcoxon signed-rank test. The average follow-up duration was 22.9 weeks (range, 8-56 weeks). RESULTS: Placement was successful in all cases. The 30-day mortality rate was 0%. The survival rates were 38% and 24% at 20 and 50 weeks, respectively. Seventy-seven percent of study @entity1 had adequate palliative drainage during their the remainder of their lives. The stent patency rates were 71% and 48% at 20 and 50 weeks, respectively. Three @entity1 (23%) presented with @entity432 requiring repeat intervention. There were no procedure-related complications such as proximal or distal migration. No complications occurred other than @entity432 . One @entity1 's stent was removed under endoscopic guidance 15 weeks after its insertion. @entity648 levels had significantly decreased 1 week after stent insertion (P <.001). CONCLUSION: Preliminary results suggest that placement of a flared @entity2636 -covered self-expandable @entity5648 stent is feasible and effective in achieving biliary drainage. The stents do not migrate, but there is @entity5 ingrowth into the flared portion of the stent. Treatment of a larger group of @entity1 will be mandatory to validate these long-term results.

title: Flared @entity2636 -covered self-expandable @entity5648 stent for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant disease', 'malignant biliary obstruction']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin', 'Bilirubin']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['stent occlusion']

entities_list: @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant biliary obstruction']


abstract: The @entity2339 is an essential component for the maintenance of homeostasis following @entity130 . Major surgical @entity130 often induces overwhelming inflammatory responses leading to @entity881 . This study was designed to evaluate the adrenal responses both before and after various degrees of surgical @entity130 and to determine the incidence of postoperative relative @entity1887 resulting in the marked inflammatory response often associated with @entity260 . Fifty-one surgical @entity1 were divided into groups who underwent major, moderate, and minor surgeries. Before the operation and during resting conditions, a short corticotropin ( @entity4545 ) stimulation test was performed in each @entity1 . The postoperative concentrations of serum @entity701 , @entity650 , @entity688 , @entity1851 ( @entity1851 ), and plasma @entity4545 were measured. Fifty of 51 @entity1 were identified as responders to @entity4545 . The postoperative @entity701 levels were the same as those obtained by @entity4545 stimulation in highly and moderately stressful surgeries. The increases in postoperative @entity650 and @entity1851 levels were greatest with major surgery, intermediate with moderate surgery, and least with minor surgery. Furthermore, plasma @entity4545 levels increased after major and moderate surgeries; however, there was no significant differences in postoperative serum @entity688 levels. @entity1850 ( @entity1850 ) was found in 11 of 17 @entity1 (64.7%) who underwent major surgery and in 4 of 16 @entity1 (25%) who underwent moderate surgery (p=0.037). The duration of @entity1850 was significantly longer in @entity1 undergoing major surgery (62+/-20 hrs) than in @entity1 undergoing moderate surgery (21+/-3 hrs, p=0.038). @entity260 were more frequent in @entity1 undergoing major surgery (41.2%) than in @entity1 undergoing moderate surgery (6.3%, p=0.039). Furthermore, there were significant differences in the length of the postoperative stay among the three groups (p<0.01). One nonresponder had serious postoperative inflammatory complications. These results suggest that a short @entity4545 stimulation test performed preoperatively is a helpful method for determining the maximal @entity701 response to surgical @entity130 and to identify high-risk individuals and that a relative postoperative @entity1887 may be closely related to the decreased @entity701 secretion following major surgical @entity130 .

title: Surgical @entity130 -induced XXXX is associated with postoperative inflammatory responses.

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Postoperative complications']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['hypothalamic-pituitary-adrenal axis']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity1850 :: ('MESH:D018746', 'Disease') :: ['SIRS', 'Systemic inflammatory response syndrome']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['sepsis and organ dysfunction']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1887 :: (MESH:D000309,Disease) :: ['adrenal insufficiency']


abstract: BACKGROUND: @entity120 ( @entity120 ) is a significant cause of morbidity and mortality in @entity1 suffering from @entity358 . Diagnosis of @entity120 has always been a major clinical dilemma due to its non-specific clinical manifestations. However, diagnosing @entity120 and determining its severity are essential for the prognosis and treatment planning in @entity120 @entity1 . This study aimed at evaluating the correlation between the pulmonary artery diameter (PAD) in the @entity551 (PAP) in echocardiography of @entity1 . MATERIALS AND METHODS: PAD was evaluated in the CT-scan of 117 @entity1 suffering from @entity401 ( @entity401 ) and the correlation between PAD and PAP was studied. A receiver operating characteristic curve (ROC curve) which is indicative of the precision of the diagnostic test was drawn to find the cut off point for the MPAD representing @entity120 . The area under the curve was also calculated in order to define the discriminative power of the test. RESULTS: PAP higher than 25 mmHg was considered as @entity120 . PAD over 29 mm reported in the CT-scan for the diagnosis of @entity120 in @entity401 @entity1 had sensitivity of 63% and specificity of 41.5%. No significant linear correlation was found between PAD and PAP (P-value = 0.17, r = 0.15). The area under the ROC curve was calculated to be 0.49 in the cutoff point of 29 mm for determining @entity120 (CI 95% = 0.38-0.60, P = 0.89). CONCLUSION: ROC curve showed a weak discriminative power. PAD had low sensitivity and specificity in the CT-scan for the diagnosis of @entity120 . Therefore, we conclude that CT-scan alone is not helpful in finding @entity120 cases and further examinations are required.

title: Correlation between the Pulmonary Artery Pressure Measured in Echocardiography and Pulmonary Artery Diameter in the CT-Scan of @entity1 Suffering from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['Pulmonary hypertension', 'PH']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary parenchymal diseases']

entities_list: @entity401 :: ('MESH:D017563', 'Disease') :: ['ILD', 'interstitial lung disease']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['CT-scan and pulmonary artery pressure']

answer: @entity401 :: (MESH:D017563,Disease) :: ['Interstitial Lung Disease']