abstract: Retroviral-mediated cytokine gene transfer into @entity5 cells is a highly effective way of inducing @entity5 inhibition and immunity. We analyzed the tumorigenicity of C-26 @entity19 @entity694 cells transduced with genes encoding the two subunits of @entity19 interleukin-12 (IL-12) in a polycistronic retroviral vector and selected for resistance to G418 and for IL-12 production (30-80 pg/ml). BALB/c @entity19 injected s.c., i.v. and intrasplenically with C-26/IL-12 cells from three different IL-12-producing clones showed delayed @entity5 onset as compared with @entity19 injected with control NeoR-transduced or parental @entity5 cells. Although C-26/IL-12 @entity5 -bearing @entity19 eventually died of lung metastasis, their survival time was twice as long as that of @entity19 injected with control cells. In experiments with @entity19 selectively depleted of natural killer (NK) cells before @entity5 cell injection, the time of @entity5 onset and survival of @entity19 injected with C-26/IL-12 s.c. and i.v., respectively, was reduced. CD8+ T cell depletion had no effect on latency or survival, whereas removal of @entity1961 + T cells led to C-26/IL-12 @entity5 regression in about 40% of @entity19 . Histological and immunocytochemical characterization of leukocytes infiltrating C-26/IL-12 @entity5 showed only slight infiltration with few T cells in non-depleted @entity19 but abundant infiltration by CD8+ T cells and asialo-GM1+ NK cells in @entity5 of @entity19 depleted of @entity1961 + T cells. The lack of CD8+ T cell infiltration is not due to a @entity1961 -mediated suppression of their activation because irradiated C-26/IL-12 cells primed for the induction of a strong cytotoxic T lymphocyte response against C-26 parental cells and induced CD8+ effector cells that protected against C-26/IL-12 in a Winn assay. Rather, the results suggest that, although C-26/IL-12 cells injected in vivo stimulate both NK and CD8+ T cells, @entity5 infiltration by the latter is inhibited by @entity1961 + T cells.

title: @entity1961 T cells inhibit in vivo the CD8-mediated immune response against @entity19 XXXX cells transduced with interleukin-12 genes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinoma']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon carcinoma']


abstract: BACKGROUND: The optimal timing for stent removal after renal transplantation remains controversial. This article describes an interim analysis of a randomized, prospective, double-blind trial aimed at detecting differences in urological complications between early ureteral stent removal at 1 week and routine ureteral stent removal at 4 weeks. METHODS: Between October 2010 and March 2015, 103 @entity1 who underwent living donor renal transplantation at a single center were pre-operatively randomly assigned to the early ureteral stent removal (at 1 week) group or the routine ureteral stent removal (at 4 weeks) group. Urinary symptoms, auxiliary examination results, and obstruction events were recorded during 3 months of follow-up. A cost analysis of both the hospitalization and postoperative periods was discussed. RESULTS: In total, 52 @entity1 in the 1-week stent group and 51 @entity1 in the 4-week stent group were analyzed. No serious adverse events were reported. Three episodes of @entity293 ( @entity293 ) occurred in the 1-week stent group, and 18 such episodes were recorded in the 4-week stent group (5.8% vs 29.4%; P  = .002). After adjusting for age, sex, @entity63 time, renal artery number, body mass index, multiple arteries, and associated medical illness, regression analysis indicated that only stent duration was associated with UTI (OR, 8.791; 95% CI, 1.984-38.943; P  = .004). CONCLUSIONS: The results of our study demonstrate that ureteral stent removal at 1 week reduces the risk of @entity293 compared with routine removal at 4 weeks. Similar effects of ureteral stent removal on complication rates are observed for these two removal times.

title: Early Removal of Double-J Stents Decreases XXXX in Living Donor Renal Transplantation: A Prospective, Randomized Clinical Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['UTIs', 'urinary tract infections']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

answer: @entity293 :: (MESH:D014552,Disease) :: ['Urinary Tract Infections']


abstract: BACKGROUND: @entity6864 ( @entity6864 ) is a ligand-activated transcription factor, which regulates gene expression of the key proteins involved in lipid metabolism, @entity32 , and proliferation. @entity6864 may contribute to attenuating @entity731 . @entity6864 @entity24198 substitution is associated with a reduced risk of @entity453 ( @entity453 ). Whether or not the gene substitution alters the risk of @entity453 in @entity6 ( @entity6 ) @entity1 remains unclear. METHODS: A total of 556 unrelated subjects from a Chinese Han population, including 89 healthy subjects, 78 @entity453 @entity1 , 86 @entity6 @entity1 , and 303 @entity453 combined with @entity6 @entity1 , were recruited to enroll in this study. PPARgamma @entity24198 gene polymorphism was determined by polymerase chain reaction and restriction fragment length polymorphisms. Plasma levels of lipoproteins, apolipoproteins, @entity413 , and insulin were measured by ELISA or radioimmunoassay (RIA). The coronary artery lesions were evaluated by coronary angiography. RESULTS: The frequency of the 161T allele in @entity453 , @entity6 , and @entity453 combined with @entity6 @entity1 was similar to that observed in the healthy control group. However, in @entity453 combined with @entity6 @entity1 , the group with angiographically documented moderate stenoses had a higher frequency of the 161T allele in comparison to the group with severe stenoses (P < 0.05). Moreover, in @entity453 with @entity6 @entity1 , the @entity412 levels and @entity755 in CC homozygote carriers were significantly higher than those in "T" allele carriers. CONCLUSIONS: PPARgamma @entity24198 genotypes weren't significantly associated with the risk of @entity453 , but were markedly correlated with severity of disease vessels in @entity1 with @entity453 and @entity6 . Furthermore, PPARgamma @entity24198 substitution was associated with an altered adipose, but not @entity413 metabolism. These results indicate that the @entity6864 @entity24198 polymorphism may reduce the risk of severe @entity731 by modulation of adipose metabolism, especially @entity1674 and @entity755 , in Chinese @entity1 with @entity453 and @entity6 .

title: @entity6864 gene @entity24198 substitution alters lipid profile in Chinese XXXX with @entity6 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['vascular inflammation']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['T2DM', 'type 2 diabetes mellitus']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherogenesis and postangioplasty restenosis', 'atherogenesis']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity6864 :: ('5468', 'Gene') :: ['Peroxisome proliferator-activated receptor gamma', 'PPARgamma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The effect of @entity14595 virus (VHSV) was studied on the established @entity5660 ( @entity5660 ) monocyte/macrophage-like cell line RTS11. The virus was not able to complete its replication cycle as infectious viral particles were not released from the cells. However, in RTS11, the virus was capable of producing mRNA from at least its N and G genes. At the protein level, only N protein was detected 2 days post-infection, whereas a faint band corresponding to the G protein was also observed after 5 days post-infection. These results suggest an interruption of viral protein translation at some point. The expression of N mRNA was significantly inhibited in cells pre-treated with Poly I:C, but not affected by @entity13129 ( @entity13130 ), an inhibitor of the dsRNA-dependent protein kinase ( @entity14596 ), thus indicating that @entity14596 has no effect on mRNA expression directly. However, when cells were preincubated with Poly I:C in the presence of 2-AP, the levels of N mRNA were restored suggesting that Poly I:C can limit viral transcription through an antiviral mechanism dependent of @entity14596 . The effect of VHSV on the expression of transcripts for different immune genes was determined, but significant induction was found only for genes related to the type I interferon (IFN) response, such as @entity14597 and the three Mx isoforms. Heat-inactivated virus failed to induce @entity14597 , suggesting that early events in the VHSV life cycle were necessary for the type I IFN response. Poly I:C alone also induced transcripts for the antiviral Mx proteins. Prior exposure of RTS11 to VHSV did not prevent Poly I:C from inducing transcripts for @entity14598 , @entity14599 and Mx3. Perhaps the failure of VHSV to disable antiviral mechanisms in RTS11 accounts for the @entity281 .

title: Effects of @entity14595 virus (VHSV) on the XXXX ( @entity5660 ) monocyte cell line RTS-11.

entities_list: @entity5660 :: ('8022', 'Species') :: ['Oncorhynchus mykiss', 'rainbow trout']

entities_list: @entity14595 :: ('MESH:D031941', 'Disease') :: ['viral hemorrhagic septicemia']

entities_list: @entity13129 :: ('MESH:D015075', 'Chemical') :: ['2-aminopurine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['aborted infections']

answer: @entity5660 :: (8022,Species) :: ['rainbow trout']


abstract: During the past 8 years we have treated 268 @entity1 with primary @entity157 ( @entity157 ); total extirpation of the @entity5 was carried out in 138. Thirty-one of the @entity1 with resectable HCCs had already been treated with transcatheter @entity1416 (TAE) of the liver before they were referred to us. The clinical values of preoperative TAE were retrospectively evaluated for those 31 @entity1 and for the remaining 107 @entity1 without TAE. There were no substantial differences between the two study groups in the clinical and histopathologic backgrounds. No differences were observed in the extent of liver resection, estimated @entity190 during surgery, and operation time. During surgery, however, troublesome intra-abdominal complications relevant to TAE were encountered in 15 @entity1 , and detection of @entity5 was impossible, even with intraoperative ultrasonography, in five @entity1 in the group with TAE. Such findings were not present in any of the @entity1 without TAE. Postoperative morbidity and mortality rates were similar in the two groups. There was no significant difference in the rate of recurrence of @entity5 in the liver, but the recurrence time was significantly shorter in the group with TAE. TAE did not improve the long-term survival rates in @entity1 either with or without @entity82 . Results of our study seem to indicate that preoperative TAE is meaningless in the treatment of resectable HCCs and therefore should be avoided, particularly in @entity1 with advanced @entity1575 .

title: Adverse effects of preoperative hepatic artery chemoembolization for resectable XXXX : a retrospective comparison of 138 liver resections.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['cirrhosis of the liver']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: The aim of this study was to determine if in vitro extreme drug resistance (EDR) to @entity902 and/or @entity3907 chemotherapy was predictive of @entity1 response to intraperitoneal (I.P.) chemotherapy in @entity1 with stage III or recurrent @entity43 ( @entity43 ). Fifty-six @entity1 were retrospectively identified who underwent optimal cytoreductive surgery for primary or recurrent eOC and then received at least three cycles of either intravenous (I.V.) or I.P. chemotherapy with @entity902 and @entity1311 -based chemotherapy. EDR to @entity902 and/or @entity1311 was determined using a commercially available assay (Oncotech, Inc., Tustin, CA). The primary outcome measure was progression-free survival (PFS). Twenty-nine (52%) @entity1 received I.P. chemotherapy and 27 (48%) received I.V. chemotherapy. The @entity1 were well matched in terms of age, stage, grade and histology. Ten (35%) @entity1 in the I.OP. arm and ten (37%) @entity1 in the I.V. arm showed EDR to either @entity902 and/or @entity1311 . Median PFS for all I.P. chemotherapy @entity1 was 23 months, compared with 13 months for those receiving I.V. chemotherapy (p = 0.04). @entity1 with EDR to @entity902 and/or @entity3907 who underwent I.V. chemotherapy had a median PFS of 13.5 months, whereas those who underwent I.P. treatment had a median PFS of 15 months (p = 0.69). Median overall survival had not been reached at the time of analysis.No significant difference in PFS was noted between @entity1 who underwent I.P. and those who underwent I.V. chemotherapy when EDR was predicted to either @entity902 or @entity1311 or both. These data suggest that the decision to offer I.P. chemotherapy, with the attendant increase in morbidity, in the setting of EDR to @entity902 and/or @entity3907 chemotherapy, may not be beneficial. Prospective studies, preferably analyzing @entity902 or @entity3907 EDR individually, are required to validate these observations.

title: Correlation of extreme drug resistant assay results and progression-free survival following intraperitoneal chemotherapy for advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: Accumulating evidence suggests that @entity22373 ( @entity22373 ), which negatively regulates multiple signaling cascades including the @entity19705 and nuclear factor-kB (NF-kB) pathways, functions as a @entity3 suppressor. However, the basis for this activity is not clear. We investigated this question in a panel of @entity0 , @entity694 and @entity320 cell lines. We found that @entity22373 negatively regulated the invasion of the different @entity5 cells through three-dimensional extracellular matrix barriers by controlling the expression of matrix metalloproteinases (MMPs), particularly, @entity5782 and @entity5780 . Silencing of @entity22373 expression resulted in a highly invasive phenotype and dramatically increased levels of @entity5782 and @entity5780 expression, while overexpression of @entity22373 decreased @entity5 cell invasion in vitro and @entity3 in vivo of @entity19 @entity5 allografts. Knockdown of @entity5782 or @entity5780 in @entity22373 -knockdown cells reverted their invasiveness to normal. In contrast, when examining migration of the different @entity5 cells in a two-dimensional, barrier-less environment, we found that @entity22373 had either a positive regulatory activity or no activity, but in no case a negative one (as would be expected if @entity22373 suppressed @entity3 at the level of cell migration itself). Therefore, @entity22373 's function as a @entity3 suppressor appears to arise from its ability to negatively regulate expression of specific MMPs, and thus invasion through barriers, and not from a direct effect on the raw capacity of cells to move. The NF-kB pathway, but not the @entity19705 pathway, appeared to positively control the invasion of @entity0 cells. A regulatory loop involving an opposing relationship between @entity22373 and the NF-kB pathway may control the level of MMP expression and cell invasion.

title: @entity19705 kinase inhibitor protein suppresses nuclear factor-kB-dependent XXXX cell invasion through negative regulation of matrix metalloproteinase expression.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity22373 :: ('23980(Tax:10090)', 'Gene') :: ['RKIP', 'Raf kinase inhibitor protein']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: @entity1763 i a condition caused by lack of @entity26 in tissues and organs. The basic pathogenic mechanisms of @entity1763 are: 1) @entity519 , 2) @entity63 . The effects of perinatal @entity1763 on the brain of a neonatal baby are critical in development of @entity2806 . The diagnosis of @entity2806 is based on clinical data including course of pregnancy and delivery (Apgar score) and especially on the neurological status of the newborn (consciousness, tonus, @entity410 , reflexes, vegetative functions, etc.) and it can be confirmed by biochemical analysis and neurological examinations. The aim of this paper is to determine the importance of prenatal and perinatal risk factors for @entity2806 , as well as their effects on the development of @entity16 and further @entity16 . The research included 148 newborn @entity1 born in the period from January 1, 1996 to January 1, 1999, with gestational age of 27 to 42 weeks, with @entity2806 of the central nervosus system. The control group included 58 @entity1 of the same age and the same gestation, with generalized @entity2421 ("floppy @entity1 ") but without any signs of @entity2806 of the central nervous system. In the group of examined newborn @entity1 with @entity2806 , from 149 @entity1 1 (0.67%) died, 87 (53.89%) had normal findings, whereas the handicap was established in 61 (40.94%). @entity1763 affects the fetus and newborn @entity1 not by individual factors, but with at least three or four associated factors. The disorders caused by @entity1763 are in inverse proportion to the duration and intensity of @entity519 insults and the gestational age of the newborn.

title: Monitoring of neurological parameters in newborns with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infants', 'infant']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic ischemic lesions', 'hypoxic-ischemic encephalopathy']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications', 'neurological problems']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia', 'hypoxic']

entities_list: @entity2421 :: ('MESH:D009123', 'Disease') :: ['hypotonia']

entities_list: @entity1763 :: ('MESH:D001237', 'Disease') :: ['Asphyxia', 'Perinatal asphyxia', 'asphyxia']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['hypoxic-ischemic encephalopathy']


abstract: GOALS AND BACKGROUND: Nearly 40% of @entity5322 ( @entity5322 ) activity is located in the small intestine. An earlier study has shown that cirrhotics with @entity5273 ( @entity5273 ) have diminished intestinal @entity5322 activity. We hypothesized that oral @entity5322 substrates known to prolong QT interval may cause further prolongation of the QT interval in cirrhotic @entity1 with @entity5273 . STUDY: A total of 23 @entity1 (9 healthy controls, 6 cirrhotics without and 8 cirrhotics with @entity5273 ) participated in a study that tested this hypothesis using @entity2929 as the probe drug. @entity1 with @entity82 with and without @entity5273 were matched for age, sex, race, BMI and etiology of @entity409 . Serial electrocardiograms were obtained at baseline, after single dose of @entity2929 500 milligrams, and after 7 days of @entity2929 (500 milligrams orally twice daily). QT intervals were measured in 3 consecutive beats in 3 leads and corrected QT intervals (QTc) were obtained using various correction formulae. The maximal QTc change (/\QTc Max) after single and multiple dose administration was the primary outcome. RESULTS: At baseline, the QTc intervals (mean  S.E) in cirrhotics with @entity5273 (418  6 msec) and @entity82 (431  6 msec) were significantly higher compared with controls (388  9 msec, P=0.021). After a single dose of @entity2929 , there was no significant difference among the 3 groups in /\QTc Max (P=0.7). However, after a 7 day course, cirrhotics with @entity5273 developed significantly greater /\QTc Max (179.5  67.8 msec) compared with cirrhotics (31.2  9.5 msec) and healthy controls (38.3  3.3 msec) (P=0.03). CONCLUSION: This study suggests that @entity1 with @entity5273 are potentially at increased risk for @entity1162 when exposed to oral CYP 3A substrates with QT prolonging effect.

title: Drug-induced @entity1162 in cirrhotic XXXX with transjugular intrahepatic portosystemic shunt.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity5273 :: ('MESH:C562830', 'Disease') :: ['transjugular intrahepatic portosystemic shunts', 'TIPS']

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['abnormal QT prolongation']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Three unique collagen chains were isolated from @entity1573 sternal cartilage following pepsin solubilization of total cartilage collagens and removal of the predominant type II collagen by fractional salt precipitation. Native molecules containing 1 alpha, 2 alpha and 3 alpha chains precipitated between 0.7 M and 1.2 M @entity1219 at acidic pH and could be purified by chromatography on @entity5070 -cellulose and agarose columns. Although similar to @entity1 1 alpha, 2 alpha and 3 alpha chains, differences in the mobilities on @entity3208 gel electrophoresis, CNBr peptide profiles and @entity535 composition were found. The 1 alpha and 2 alpha chains resemble, but are structurally distinct from, the @entity1573 alpha 1(V) and alpha 2(V) chains. The 3 alpha chain appears to be closely related to the alpha 1(II) chain, although some differences in the cyanogen @entity4001 peptides suggest that they might be different gene products. In addition, two collagenous fragments of Mr 140 000 (M1) and 35 000 (M2) were found which precipitated at 2.0 m @entity1219 at acidic pH. Both fragments contain interchain @entity1520 bonds. The larger fragment was @entity2198 . The smaller fragment gave rise to peptides of Mr about 12 000 and 10 000 after reduction. By the technique of rotary shadowing the native, unreduced larger fragment M1 appeared as a slender rod-like molecule with a distinct bend approximately 40 nm from one end. We interpret this finding as indicative of a focal @entity535 sequence irregularity, disrupting the triple-helical conformation.

title: Isolation and characterization of new collagens from XXXX cartilage.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity2198 :: ('MESH:D006316', 'Disease') :: ['reducible to subunits of approximate Mr 120 000, 48 000, 28 000 and 11 000']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecylsulfate']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity5070 :: ('CHEBI:41402', 'Chemical') :: ['carboxymethyl']

entities_list: @entity1520 :: ('CHEBI:48343', 'Chemical') :: ['disulfide']

entities_list: @entity4001 :: ('CHEBI:15858', 'Chemical') :: ['bromide']

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: UNASSIGNED: @entity483 is one of the most frequent @entity56 in @entity235 . There are many methods of treating its symptoms but specific immunotherapy has recently gained high popularity. Before the application of specific immunotherapy, it is necessary to identify the allergens provoking the reaction of @entity56 in the selected animal. This raises a question about the method of allergen identification the medical practitioner decides to use in order to obtain the most credible result. The authors of the present study decided to compare the results of intradermal allergic tests and the results of an IgE screening test carried out using the Fc  RIa receptor method. The aim of the study was to compare the results of both tests directed to dust and storage mites. The study proves that in case of the IgE screening tests (for a group of allergens), the sensitivity is quite high (85 to 90.69%) but the specificity of these tests is insufficient (25 to 50%). In case of antibodies for the selected mites the sensitivity and specificity was too low (65.1 to 89.4% for the sensitivity, with only 14.2 to 33.3% for the specificity). Only in case of D. petronyssinus the results were higher with the sensitivity calculated at 65.1% and the specificity at 80%. The IgE screening test carried out using the Fc  RIa receptor method is reliable only in case of screening test for mites and the intradermal allergic test remains the gold standard for @entity566 testing.

title: Comparison of IgE test results with intradermal skin tests for dust mites and storage mites in atopic XXXX .

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['Atopic dermatitis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases', 'hypersensitivity']

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: OBJECTIVE: Endoscopic transpapillary stenting (ETS) of the pancreatic duct facilitates ductal outflow and may reduce time to @entity3472 . However, data on the feasibility of ETS in @entity1 with @entity788 are scarce. BACKGROUND: @entity3472 often occur after intervention in @entity788 and frequently close only after months of conservative treatment. METHODS: From a prospective cohort of @entity1 with acute @entity788 admitted in 15 hospitals (2004-2007), all @entity1 who underwent ETS or conservative treatment for a @entity3472 were identified. Safety, feasibility, and outcome of ETS were evaluated. Furthermore, a literature review was performed for similar studies in @entity788 . RESULTS: Of 731 @entity1 with acute @entity788 , 19 @entity1 were treated with ETS and 16 @entity1 were treated conservatively for a @entity3472 . Fistula closure was achieved in 16 of 19 @entity1 (84%) in the ETS group and in 8 of 12 @entity1 (75%) in the conservative group (P = 0.175). The median time to @entity292 closure after ETS was 71 days (interquartile range [IQR] 34-142) compared with 120 days (IQR 51-175 days) in the conservative group (P = 0.130). Complications were observed in 6 @entity1 . A total of 10 studies reporting the results of 281 @entity1 with stent placement for @entity3472 were included in the literature review. Fistula closure was achieved in 200 @entity1 (71%). Stent-related complications were reported in 9% of @entity1 . CONCLUSIONS: ETS seems a feasible and safe alternative to conservative treatment in @entity1 with @entity3472 after intervention for @entity788 .

title: Endoscopic transpapillary stenting or conservative treatment for @entity3472 in XXXX : multicenter series and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'necrotizing pancreatitis']

entities_list: @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistulas', 'pancreatic fistula closure', 'pancreatic fistula', 'Pancreatic fistulas']

answer: @entity788 :: (MESH:D010190,Disease) :: ['necrotizing pancreatitis']


abstract: @entity439 in the supra-aortic extracranial arteries are rare in neurovascular pathology. Conventional surgery is effective but technically demanding and successful endovascular repair is reported. We treated 5 @entity1 with supra-aortic extracranial artery @entity439 at our hospital (mean age 53.8 years). There were 2 @entity439 of the common carotid artery, 1 of the extracranial internal carotid artery, 1 of the subclavian artery, and 1 located at the innominate artery. Four @entity1 were symptomatic. The lesion was the result of @entity130 in 3 @entity1 . The procedure was conducted using bare stent placement and coil embolization of the @entity439 in 2 @entity1 , covered stent in 2 @entity1 , and bare stent only in 1 @entity1 . No periprocedural complications occurred. Follow-up angiography revealed asymptomatic stent @entity715 in a @entity1 treated using a covered stent, but the remaining 4 @entity1 showed successful treatment of the @entity439 with the parent arteries remaining patent. Follow-up clinical assessment ranged between 30 and 81 months. The @entity1 with stent @entity715 died of unrelated pathology; the remaining @entity1 did not experience @entity439 recurrence, @entity548 , or distal @entity1031 .

title: Interventional neuroradiological techniques for the treatment of XXXX of the supra-aortic extracranial arteries.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'Aneurysms']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysms']


abstract: The @entity5271 ( @entity5271 ) induces @entity141 oscillations and activates the @entity25314 ( @entity25314 ) during osteoclast differentiation (osteoclastogenesis). @entity141 oscillations are an important trigger signal for osteoclastogenesis, however the molecular basis of @entity141 permeable influx pathways serving @entity141 oscillations has not yet been identified. Using a DNA microarray, we found that @entity25315 ( @entity25315 ) are expressed significantly in @entity5271 -treated RAW264.7 cells (preosteoclasts) compared to untreated cells. Therefore, we further investigated the expression and functional role of @entity25315 on @entity141 oscillations and osteoclastogenesis. We found that @entity5271 dominantly up-regulates @entity25315 expression in preosteoclasts, and evokes spontaneous @entity141 oscillations and a transient inward cation current in a time-dependent manner. TRPV inhibitor @entity3739 red and @entity803 -induced @entity25315 silencing significantly decreased both the frequency of @entity141 oscillations and the transient inward currents in @entity5271 -treated preosteoclasts. Silencing of store-operated @entity141 entry (SOCE) proteins similarly suppressed both @entity5271 -induced oscillations and currents in preosteoclasts. Furthermore, suppression of @entity25315 also reduced @entity5271 -induced NAFTc1 expression, its nuclear translocation, and osteoclastogenesis. In summary, @entity141 oscillations in preosteoclasts are triggered by @entity5271 -dependent @entity25315 and SOCE activation and intracellular @entity141 release. Subsequent activation of @entity25314 promotes osteoclastogenesis.

title: @entity5271 -induced XXXX expression regulates osteoclastogenesis via calcium oscillations.

entities_list: @entity3739 :: ('MESH:D012428', 'Chemical') :: ['ruthenium']

entities_list: @entity5271 :: ('21943(Tax:10090)', 'Gene') :: ['receptor activator of NFkB ligand', 'RANKL']

entities_list: @entity25315 :: ('22368(Tax:10090)', 'Gene') :: ['TRPV2', 'Transient Receptor Potential Vanilloid channels 2']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity25314 :: ('18018(Tax:10090)', 'Gene') :: ['Nuclear Factor of Activated T cells 1', 'NFATc1']

answer: @entity25315 :: (22368(Tax:10090),Gene) :: ['TRPV2']


abstract: PURPOSE: This study discusses the rationale, modifications, and complications of an osteotomy technique used to increase malar projection. @entity1 AND METHODS: Seventy "sandwich" zygomatic osteotomies were performed in a 6-year period. @entity692 (HA) blocks were used to stabilize the anterolateral rotation of the zygomatic body in 44 osteotomies, @entity4959 blocks were used in 23, calvarial bone grafts in three, a piece of @entity291 cartilage in one, and a bone graft from a chin ostectomy procedure combined with mesh osteosynthesis in one procedure. Fifty-six zygomatic osteotomies were combined with Le @entity196 (eight with a midline split). Nineteen zygomatic osteotomies were performed simultaneously with a Le @entity196 and a rhinoplasty with @entity5251 . RESULTS: The increase of malar projection and the stability of the procedure could not be measured on conventional three-plane cephalograms. However, @entity1 's and surgeon's satisfaction were high and remained so during the follow-up period (maximum, 6.5 years; minimum, 6 months). Three @entity1 developed @entity1180 . In two of them, this was clearly related to fragmentation of an @entity616 . A @entity8222 @entity1 developed a chronic @entity292 in the upper vestibule, caused by leakage of infraorbitally placed HA granules. In two cases, a @entity174 of the zygomatic arch occurred. Osteosynthesis was performed in one of them. CONCLUSION: With proper technique and care not to @entity174 the interpositional @entity616 , complications are rare. The procedure is expedient and provides predictable and stable correction of @entity942 .

title: Six year's experience with the zygomatic "sandwich" osteotomy for correction of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['Hydroxyapatite']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['Fort I-type osteotomy', 'Fort I-type osteotomies']

entities_list: @entity8222 :: ('MESH:D008342', 'Disease') :: ['Treacher-Collins']

entities_list: @entity4959 :: ('MESH:D002119', 'Chemical') :: ['calcium carbonate']

entities_list: @entity5251 :: ('MESH:D010509', 'Disease') :: ['lateral osteotomies']

entities_list: @entity1180 :: ('MESH:D015523', 'Disease') :: ['maxillary sinusitis']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['malar deficiency']

answer: @entity942 :: (MESH:D003677,Disease) :: ['malar deficiency']


abstract: RATIONALE: Studies of the genetics of @entity27 may be facilitated by identifying intermediate traits with high heritability that quantify etiological pathways, such as those related to respiratory control. Electrocardiogram (ECG)-based sleep spectrograms, measuring the coupling between respiratory modulation of ECG QRS-wave amplitude and heart rate variability, may provide measures of sleep state and ventilatory dynamics during sleep. We evaluated the @entity1423 of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency cardiopulmonary coupling (e-LFC), to assess their utility in genetic studies. METHODS: 622 @entity1 from 137 families from the Cleveland Family Study underwent standardized polysomnography (PSG). From the ECG signal on the PSG, the interbeat interval time series and the corresponding ECG-derived respiratory signal were extracted, and the low frequency (0.01-0.1 Hz) component of their coupling was computed using a fully automated method. Narrow sense heritability of e-LFC was calculated using variance component methods. RESULTS: A spectral marker of abnormal low frequency cardiopulmonary coupling (e-LFC) demonstrated moderate correlation with @entity27 index (AHI; r = 0.35, P < 0.0001). The heritability estimate for e-LFC, after adjusting for age and sex was 0.32 (P < 10-5) and remained unchanged after additionally adjusting for body mass index or AHI. In biological relatives of those with @entity387 , a related marker of e-LFC was more prevalent than in controls (P = 0.05). CONCLUSIONS: Approximately 30% of the variability of e-LFC, measured from a continuous ECG during sleep, is explained by familial factors other than BMI. ECG-based spectrographic measures of cardiopulmonary coupling may provide novel phenotypes for characterizing subgroups of individuals with different propensities and genetic etiologies for @entity387 or for other conditions associated with @entity1949 .

title: Heritability of abnormalities in XXXX : use of an electrocardiogram-based technique.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep fragmentation']

entities_list: @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep apnea']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['familial aggregation']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea hypopnea', 'obstructive sleep apnea']

answer: @entity387 :: (MESH:D012891,Disease) :: ['cardiopulmonary coupling in sleep apnea']


abstract: BACKGROUND: Endovascular recanalization of a @entity2998 (ICA) with underlying @entity850 may be challenging owing to a possible @entity715 component. This is especially true when the landing zone for a balloon-tipped guiding catheter (BGC) at the bulb portion is insufficient. Sequential application of the balloons of a BGC and an angioplasty catheter may prevent @entity1031 during revascularization. This study analyzed the safety and effectiveness of this relay-balloon technique. METHODS: Ten consecutive @entity1 with acute symptomatic @entity432 were treated by the relay-balloon technique. Outcomes analyzed included technical success rate, procedure-related complications, and short-term clinical outcomes. RESULTS: Successful revascularization was achieved in all 10 @entity1 . One @entity1 experienced a post-procedural @entity1188 extension, but there was no change in National Institutes of Health @entity64 Scale (NIHSS) score. Mean NIHSS score decreased from 12.0  5.6 (range 0-18) initially to 6.8  5.4 (range 0-18) at discharge. CONCLUSIONS: The relay-balloon technique is safe and effective in the endovascular revascularization of acute symptomatic proximal ICA occlusions, which are at high risk of distal @entity1031 due to insufficient landing zone for the BGC.

title: Relay-balloon technique for recanalization of acute symptomatic proximal internal carotid XXXX with short balloon-tipped guiding catheter landing zone.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['completely occluded proximal internal carotid artery']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['proximal ICA occlusion']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity432 :: (MESH:D001157,Disease) :: ['artery occlusion']


abstract: Regional differences in contraction produced by @entity2710 and electric field stimulation (EFS) and in relaxation produced by @entity3044 , @entity1421 and @entity1855 were studied in isolated @entity235 airway smooth muscle in vitro. Low-frequency EFS (3 Hz, 0.5 msec, 50 V) contracted thoracic trachealis to 43% of maximal EFS response, whereas cervical trachealis contracted to only 14% of maximum. EFS at 10 Hz produced 75% of the maximal response in both regions of the @entity825 . These EFS responses were abolished by 0.1 microM @entity1022 and 1.0 microM @entity3897 . Contraction produced by EFS was also matched in each tissue by contraction with @entity2710 . The concentrations of @entity2710 that matched EFS at 10 Hz were 52 +/- 7, 378 +/- 84 and 66 +/- 11 nM for cervical and thoracic trachealis and lobar bronchi, respectively. Both EFS and matched @entity2710 contractions of cervical trachealis and lobar bronchi were completely relaxed by @entity3044 , whereas thoracic trachealis relaxed maximally to only 60% of induced tone. When @entity1855 was used to relax EFS and matched @entity2710 contractions, cervical trachealis was completely relaxed whereas thoracic trachealis relaxed to 15% of induced tone. Although there was a regional difference in the relaxant potency of @entity3044 and, to some extent, @entity1855 , there was no difference in @entity3044 or @entity1855 EC50 values for EFS vs. matched @entity2710 contractions within each region. In contrast, EFS contractions of thoracic trachealis were more sensitive to @entity1421 -induced relaxation than were matched @entity2710 contractions. These data demonstrate marked differences in cholinergic and beta adrenergic receptor-mediated responses between regions of the tracheobronchial tree.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Regional differences in relaxation of electric field-stimulated @entity235 airway smooth muscle by @entity1855 , @entity3044 and XXXX .

entities_list: @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil']

entities_list: @entity1022 :: ('MESH:D013779', 'Chemical') :: ['tetrodotoxin']

entities_list: @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

entities_list: @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']

answer: @entity1421 :: (MESH:D015232,Chemical) :: ['prostaglandin E2']


abstract: @entity2583 is a fulminant, devastating @entity364 . The use of @entity2379 , combined with @entity146 surgical debridement, has increased survival rates from approximately 20% to 70%. Eleven @entity1 with this @entity395 have been treated over the past 6 years. Therapy with @entity2379 was begun in all @entity1 as soon as the diagnosis of @entity2583 was suspected. Seven @entity1 underwent @entity146 surgical debridement; all seven had disease involving the sphenoethmoidal complex, requiring external ethmoidectomy with or without sphenoidotomy. Six @entity1 had @entity1177 , requiring Caldwell-Luc antrostomy or maxillectomy. Three @entity1 required orbital exenteration. Surgery was performed within 24 hours of diagnosis on all but two of our @entity1 . Despite prompt diagnosis, @entity146 surgical debridement, therapy with @entity2379 , and correction of @entity520 , our mortality rate was 82%. @entity2583 remains a rapidly progressive, frequently fatal disease.

title: @entity2583 : results of @entity146 surgical debridement and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2583 :: ('MESH:D009091', 'Disease') :: ['Rhinocerebral mucormycosis', 'mucormycosis']

entities_list: @entity1177 :: ('MESH:D008444', 'Disease') :: ['maxillary sinus disease']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal disease']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disease']

answer: @entity2379 :: (MESH:D000666,Chemical) :: ['amphotericin B']


abstract: OBJECTIVES: To investigate intra- and inter-reader agreement of ultrasonography (US) and conventional radiography (CR) for the evaluation of osteophyte presence and size within the tibiofemoral joint. In addition, to correlate these findings with @entity528 . METHOD: Forty adult @entity1 with knee @entity158 were enrolled in this study. Knee CR and US scanning of the medial and lateral bone margins were performed on all @entity1 . A novel atlas for the US grading of knee osteophytes was used in the evaluation. The number and size of the osteophytes were evaluated semi-quantitatively in two rounds from both the CR images (four readers) and the US images (14 readers). The Noyes grading system was used for the evaluation of @entity528 in 26 @entity1 . RESULTS: On average, intra- and inter-reader US and CR agreement was substantial and comparable to each other (k  =  0.60-0.72). US detected more osteophytes than CR at both the medial (65% vs. 48%) and lateral (70% vs. 60%) compartments. A statistically significant correlation between CR- or US-based osteophyte and arthroscopy grades was observed only for US at the medial compartment (rs  =  0.747, p  <  0.001). CONCLUSIONS: The detection of knee osteophytes using the novel US atlas is as reproducible as reading conventional radiographs. US is more sensitive to detect knee osteophytes than CR. Furthermore, osteophytes detected with US correlate significantly with arthroscopic cartilage changes at the medial knee compartment whereas those detected by CR do not.

title: Atlas-based knee osteophyte assessment with ultrasonography and radiography: relationship to XXXX .

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['arthroscopic degeneration of the articular cartilage']

answer: @entity528 :: (MESH:D009410,Disease) :: ['arthroscopic degeneration of articular cartilage']


abstract: BACKGROUND: Bilateral total knee arthroplasty is generally accompanied by a significant amount of @entity190 . We investigated the relationship between the intensity of @entity158 and the amount of @entity190 in the early postoperative period after bilateral total knee arthroplasty. METHODS: A prospective study was conducted on 91 @entity1 who underwent elective sequential bilateral total knee arthroplasty for @entity571 . All @entity1 received combined spinal and epidural anesthesia. @entity1 were divided into three groups based on their scores on the verbal numerical rating scale (VNRS) for @entity158 at 6 hours postoperatively. The VNRS was classified as follows; mild @entity158 (n = 34, VNRS score 0-4), moderate @entity158 (n = 24, VNRS score 5-6), and severe @entity158 (n = 33, VNRS score 7-10). We compared the mean arterial pressures and the amount of @entity190 during the first 24 postoperative hours in the three groups. Factors influencing @entity86 were analyzed. RESULTS: Postoperative mean arterial pressures and @entity190 were not different among the groups. Of the factors examined, the amount of @entity86 was only dependent on the amount of intraoperative @entity190 (P = 0.001). CONCLUSIONS: Early @entity282 has no effect on postoperative blood pressure and the amount of @entity190 after bilateral total knee arthroplasty. For @entity86 , intraoperative @entity190 is the main determinant.

title: The effect of @entity282 on XXXX after sequential bilateral total knee arthroplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative blood loss']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity86 :: (MESH:D019106,Disease) :: ['postoperative blood loss']


abstract: OBJECTIVE: To study childhood risk factors for @entity5815 in adult life. DESIGN: Examination of data from the 1970 British birth cohort. @entity1 : 16,567 babies born 5-11 April 1970, followed up at 5, 10, 16, and 29-30 years. MAIN OUTCOME MEASURES: @entity5815 / @entity5815 (CFS/ME) identified by self report at age 30 years. Data from childhood from questionnaires given to parents and teachers. Maternal mental health assessed with the malaise inventory. RESULTS: 93 (0.8%, 95% confidence interval 0.7 to 1.0) of 11 261 @entity1 reported ever having CFS/ME, and 48 (0.4%, 0.3 to 0.6) had the condition currently. Higher risk of CFS/ME was associated with having a limiting longstanding condition in childhood (odds ratio 2.3, 1.4 to 3.9), female sex (2.3, 1.4 to 2.6), and high social class in childhood (2.2, 1.4 to 3.5). Higher levels of exercise in childhood were associated with lower risk (0.5, 0.2 to 0.9). @entity74 , @entity458 in childhood, birth weight, birth order, atopy, @entity28 , school absence, academic ability, and parental illness were not associated with risk of CFS/ME. CONCLUSIONS: We identified no association between maternal or @entity1 @entity458 , academic ability, parental illness, @entity600 and increasing risk of lifetime CFS/ME. Sedentary behaviour increased the risk.

title: Childhood predictors of self reported @entity5815 / XXXX in adults: national birth cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS', 'child']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress', 'psychological problems']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['atopy, or birth order']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Maternal psychological disorder']

entities_list: @entity5815 :: ('MESH:D015673', 'Disease') :: ['chronic fatigue syndrome', 'myalgic encephalomyelitis', 'Chronic fatigue syndrome']

answer: @entity5815 :: (MESH:D015673,Disease) :: ['myalgic encephalomyelitis']


abstract: OBJECT Internal carotid artery (ICA) @entity397 during @entity1104 ( @entity1104 ) is an extremely difficult complication to treat. This study aimed to evaluate the immediate and long-term outcomes of covered stent placement for emergency reconstruction of ruptured ICAs during or after @entity1104 . METHODS Seven @entity1 underwent covered stent placement for emergency reconstruction of a @entity3538 during or after @entity1104 . The safety and effectiveness of covered stent placement for emergency reconstruction of ruptured ICAs were retrospectively analyzed. RESULTS Pretreatment angiography showed active @entity548 in 6 @entity1 (5 intraoperative and 1 postoperative) and a @entity2849 in 1 @entity1 . Of the 6 @entity1 with active @entity548 , 5 were treated with a successive operation to control active @entity548 . The other @entity1 was treated just after cardiopulmonary resuscitation due to massive @entity1415 20 days after revision of @entity1104 . All active @entity548 was controlled immediately after covered stent insertion in these 6 @entity1 . One @entity1 showed a gap between the covered stent and ICA wall without active @entity548 30 minutes after glycoprotein IIb/IIIa inhibitor administration due to in-stent @entity715 . The gap was occluded with coil embolization after completion of the temporarily suspended @entity1104 . The seventh @entity1 , whose ICA tear was treated with surgical suture, underwent covered stent placement for a @entity2849 detected on postoperative Day 2. During a mean follow-up period of 46 months (range 12-85 months), all @entity1 had excellent outcomes (modified Rankin Scale score of 0). All the stented ICAs were patent on vascular imaging follow-up at a mean of 34 months (range 12-85 months). CONCLUSIONS Covered stents appear to be a safe and effective option for emergency reconstruction of ruptured ICAs during or after @entity1104 .

title: Jostent covered stent placement for emergency reconstruction of a XXXX during or after @entity1104 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1415 :: ('MESH:D004844', 'Disease') :: ['nasal bleeding']

entities_list: @entity3538 :: ('MESH:D002341', 'Disease') :: ['ruptured ICA']

entities_list: @entity1104 :: ('MESH:D000267', 'Disease') :: ['transsphenoidal surgery', 'TSS']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

answer: @entity3538 :: (MESH:D002341,Disease) :: ['ruptured internal carotid artery']


abstract: UNASSIGNED: e15106 Background: @entity2240 malate is a @entity4149 kinase inhibitor approved for the treatment of @entity1358 ( @entity1358 ). @entity407 is not described among @entity1 on @entity2240 ; however, it may induce an @entity1375 state, possibly causing an increase of serum lipids. Here we describe the occurrence of @entity407 in @entity1 receiving @entity2240 for @entity1358 . METHODS: Between July 2008 and November 2010, we prospectively evaluated serum @entity1674 and @entity165 in 25 @entity1 receiving @entity2240 for @entity1358 (50 mg daily, according to classic 6-week schedule). Median @entity1 age was 62.9 year-old. On average they received @entity2240 for 7.2 cycles. Serum lipids and thyroid function were measured before the beginning of treatment and at the end of each @entity2240 ON period. RESULTS: At baseline median serum level of @entity1674 was 141.78 mg/dl (   22 mg/dl, 95% CI) and median @entity165 was 196.8 mg/dl (   21.8 mg/dl, 95% CI). During @entity2240 administration 16 @entity1 (64%) presented an elevation of serum lipids. These abnormalities usually developed within 2 cycles (range 1-3 cycles). In these @entity1 , a maximum increase of median @entity1674 and @entity165 of 160% and 36.1% respectively was observed. We did not observed a relationship between @entity407 and @entity1375 state.Overall, at second cycle an increase from baseline of median serum @entity1674 of 67.7% (237.57 mg/dl;    52.4 mg/dl 95% CI) was observed, while at fourth it resulted of 46.9% (208.27 mg/dl;    58,18 mg/dl 95% CI) and of 95.6% at sixth (277.22 mg/dl;    65,35 mg/dl, 95% CI). Median serum @entity165 increased of 8.7% from baseline at second cycle (214.1 mg/dl;    24.1 mg/dl 95% CI), of 4.5% at fourth (205,8 mg/dl;    22,5 mg/dl 95% CI) and 9.8% at sixth (216,1 mg/dl;    18 mg/dl 95% CI). CONCLUSIONS: @entity407 develops among @entity1 on @entity2240 . This is a side effect described with @entity3470 inhibitors, other drugs prescribed sequentially to @entity2240 in @entity1358 @entity1 . Therefore, an elevation of @entity1674 and @entity165 may persist for a long time in those @entity1 . We recommend a careful monitoring of serum @entity1674 and @entity165 among @entity1 on @entity2240 .

title: Sunitinb-induced @entity407 in XXXX with @entity1358 .

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['Hyperlipidemia', 'hyperlipidemia']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroid']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['Sunitinib', 'sunitinib']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity14799 may contribute to @entity73 in older @entity1 . Here, we examine the relation of degeneration of the striatum and substructures to @entity73 and @entity303 in subjects with a wide range of cognitive function. Data are from the prospective community-based Honolulu Asia Aging Study of Japanese American @entity1 born 1900-1919. Brain magnetic resonance imaging (MRI) (1.5 T) was acquired on a stratified subsample (n = 477) that included four groups defined by cognitive status relative to the scan date: subjects without @entity303 (n = 347), subjects identified as demented 2-3 years before brain scanning (n = 30), at the time of scanning (n = 58), and 3-5 years after scanning (n = 42). Volumes of the striatum, including the accumbens, putamen, and caudate nucleus were automatically estimated from T1 MR images. Global cognitive function was measured with the cognitive ability screening instrument (CASI), at four examinations spanning an 8-year interval. Trajectories of @entity73 were estimated for each quartile of striatal volume using mixed models, controlling for demographic variables, measures of @entity1504 , global @entity1010 , and hippocampal volume. Diagnosis of @entity303 before, during, and after brain scanning was associated with smaller volumes of n. accumbens and putamen, but not with caudate nucleus volume. Subjects in the lowest quartile of n. accumbens volume, both in the total sample and in the subjects not diagnosed with @entity303 during the study, had a significantly (p < 0.0001) steeper decline in cognitive performance compared with those in the highest quartile. In conclusion, volumes of the n. accumbens and putamen are closely associated with the occurrence of @entity303 and n. accumbens volume predicts @entity73 in older @entity1 . These associations were found independent of the magnitude of other pivotal markers of @entity73 , i.e. @entity1504 and hippocampal volume. The present study suggests a role for the ventral striatum in the development of clinical @entity303 .

title: Ventral striatal volume is associated with XXXX in older @entity1 : a population based MR-study.

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive decline']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['cerebro-vascular damage']

entities_list: @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']

entities_list: @entity14799 :: ('MESH:C537500', 'Disease') :: ['Striatal degeneration']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']


abstract: @entity8933 ( @entity8934 ) were administered and tested for the efficacy and safety in 80 elderly @entity1 who were older than 65 years of age with @entity281 . The sensitivity of bacteria found in these @entity281 to @entity8934 was examined before the administration of the drug. Serum concentrations and the rate of urinary output of the drug were examined in 3 cases. The clinical effect of @entity8934 was as follows: 29 cases (36.3%) of excellent effectiveness and 31 cases (38.8%) showed moderate effectiveness. The @entity1 were divided into 2 groups depending on the presence or the absence of other diseases in their backgrounds. Effectiveness of @entity8934 for @entity1 with and without other diseases were 74.0% and 85.7%, respectively. The effectiveness of @entity8934 in @entity1 with other diseases in their background was lower than the group without other diseases. Other antibiotics were used in 16 cases before the use of @entity8934 . The effectiveness of @entity8934 for these @entity1 was 62.5%. Infecting bacteria were detected in a total of 46 cases (19 cases of @entity1729 and 27 cases of @entity293 ). Among the respiratory cases, 8 were due to Gram-positive bacteria and 11 were due to Gram-negative bacteria. No Gram-positive organisms were detected from @entity293 , which were all due to Gram-negative bacteria. Sensitivities of isolates of these infecting bacteria to @entity8934 were very sensitive 3 isolates, sensitive (++) 8 and slightly sensitive (+) 1 isolate. It was found that @entity8934 was effective against 39 of 46 cases from which causative organisms were identified. The effectiveness ratio was 84.8%. Serum concentration of @entity8934 was determined after a drip injection of 1 g @entity8934 for 1 hour. The half-lives of @entity8934 in plasma in healthy subjects and aged @entity1 were 1.33 hours and 2.15 hours, respectively. The rate of urinary output of @entity8934 during 6 hours after the injection was 76.4% in healthy subjects. Delayed urinary output which was 58.2% during 7 hours after injection was observed in aged @entity1 . Fever in 1 @entity1 and @entity1712 in 3 cases were observed after administration of @entity8934 .

title: [Therapeutic effect of @entity8933 on XXXX in aged @entity1 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections']

entities_list: @entity8933 :: ('MESH:D015296', 'Chemical') :: ['Ceftizoxime']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infections']


abstract: Owing to gradual aging of the population, the incidence of @entity170 -related @entity174 of the proximal femur has increased. @entity173 are encountered in more than 50% of @entity173 . In this study, a comparative epidemiological analysis of @entity1 with @entity173 treated in the orthopedic department of the university hospital of Berne was performed. The time period from 1972 to 1978 (group 1, n = 205), was compared with the period from 1981 to 1989 (group 2, n = 444). Group 2 experienced a significant age-related increase of the number of @entity1 with @entity173 in the age group 30-49 years (p < 0.0001) and a significant increase of the number of @entity1 in the age group over 80 years (p < 0.0001). In group 2, the female/male ratio was 0.24/1 for @entity1 aged 30-49 years, 0.88/1 in the age group 50-59 years, 0.92/1 and 2.47/1 for @entity1 in the age groups 60-69 and 70-79 years, respectively, and 3.59/1 in individuals over 80 years of age. The increased incidence in older @entity1 with @entity173 is related to a higher grade of @entity170 and agrees with the findings in the literature. The marked increase in the incidence of @entity174 in young males could be due to a higher risk of high-energy @entity130 sustained in traffic accidents and sports. Another explanation is the increase of risk factors for @entity170 related to low-energy @entity130 over the past two decades. Overall, there was a tendency towards more complicated fracture types (AO classification) in group 2 than in group 1.

title: [Epidemiology of trochanteric femoral XXXX over 2 decades (1972-1988)].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis', 'early osteoporosis']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['trochanteric fractures', 'hip fractures', 'Trochanteric fractures']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumas', 'trauma']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: A longitudinal population study of 1462 @entity1 , aged 38-60 years, was carried out in Gothenburg, Sweden, in 1968-69. In univariate analysis anthropometric variables indicating centrally localized adipose tissue (waist circumference, the ratio of waist to hip circumference and the subscapular skinfold) showed significant age-standardized positive associations with the occurrence (prevalence + incidence data) of @entity1204 . Incidence data suggested that measurements of centrally localized adipose tissue might be of predictive value for this malignancy as well as for @entity43 . In contrast, measurements of generalized @entity28 (body weight or body mass index) or peripherally localized adipose tissue (triceps skinfold) showed no associations to these @entity5 . No relationship was observed between the anthropometric variables studied and @entity0 . The association observed between @entity43 with central adipose tissue did, however, not remain in multivariate analysis when generalized @entity28 was taken into account. Centrally localized adipose tissue is known to be associated with endocrine abberations including irregular ovulation and menstruation, re-emphasizing the importance of endocrine factors for the pathogenesis of @entity43 . No positive association was found between development of the @entity189 and initial measurements of blood @entity413 , serum lipids or blood pressure, found to be elevated in cross-sectional studies. An increase in these variables therefore probably are parallel phenomena rather than predictors. The @entity1 with @entity0 smoked more than the remaining @entity1 . Although the number of end-points observed was limited these results suggest that measurements of adipose tissue distribution might be a valuable addition to the predictors of @entity43 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Adipose tissue distribution and female @entity189 . A 12-year follow-up of XXXX in the population study of @entity1 in Gothenburg, Sweden.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'endometrial and ovarian carcinomas']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma', 'endometrial or breast carcinomas']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['participants']


abstract: PURPOSE: The combination of @entity1260 (I) and @entity2879 (E) was useful in salvaging @entity1 with recurrent/resistant @entity5 of childhood. @entity3003 (C), active against a number of pediatric @entity5 , was added to I and E to form a three-drug combination called ICE to improve the response rate. @entity1 AND METHODS: ICE, consisting of I 1.5 g/m2 plus E 100 mg/m2 i.v.q.d. x 3 plus C i.v. on day 3 only, was given in 21-28-day intervals. C was started at 300 mg/m2, and the dose was escalated in 25% increments, with three evaluable @entity1 treated at each level. RESULTS: Ninety-two @entity1 were enrolled in this phase I/II study between July 1990 and April 1993. A total of 331 courses of ICE was administered. Median courses of ICE received were three (range, 1-16). The maximum tolerated dose (MTD) for C when used in combination was found to be 635 mg/m2. The response rate for ICE at the MTD for C was complete response (CR) 26% and CR + partial response (PR) 53%. The response was even better in those who received C at the MTD: 32% achieving a CR and 63% a CR + PR. @entity3043 was the dose-limiting @entity137 . Thirteen episodes of @entity2348 were reported, none fatal. Only one @entity1 developed @entity23154 . CONCLUSION: The MTD of C when used with I and E was found to be 635 mg/m2. The overall CR + PR rate for all @entity1 treated at all C dose levels was 53%. Best responses were seen in @entity1893 , @entity521 , soft tissue @entity242 , and @entity3969 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity1260 / @entity3003 / XXXX (ICE) for recurrent @entity5 of childhood: a Pediatric Oncology Group Phase I/II study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity23154 :: ('MESH:C536855', 'Disease') :: ['a Fanconi-like syndrome']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant solid tumors', 'cancers']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['Carboplatin']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ["Wilms' tumor"]

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

entities_list: @entity3043 :: ('MESH:D010198', 'Disease') :: ['Pancytopenia']

answer: @entity2879 :: (MESH:D005047,Chemical) :: ['etoposide']


abstract: Mechanisms of resistance to the @entity5176 have been described for several bacterial species, but mainly for @entity526 and @entity794 . Two principal mechanisms have been described: 1) alteration of the DNA gyrase, which is the target site of the @entity5176 ; and 2) diminished accumulation in the cell as a result of either decreased uptake or increased efflux. Alteration of DNA gyrase is usually the result of a mutation in the gyrA, or more rarely, the gyrB gene. All substitutions in subunit A of the gyrase are located in the 67 to 106 @entity535 domain and are clustered around Ser-83 in @entity526 and Ser-84 in @entity794 . A decrease in uptake has been described for Gram-negative bacteria such as Enterobacteriaceae and @entity796 . It has almost always been correlated with a modified electrophoretic profile of outer membrane proteins of the @entity1536 -resistant mutants. In @entity526 , a decrease in OmpF seemed to be linked to the activation of the micF operon in most of the mutants described. These mutants were cross-resistant to unrelated antibiotics, such as @entity206 , @entity2755 , @entity803 , and some @entity7660 . In all these mutants the normal or enhanced efflux of @entity5176 increased the level of resistance. Enhanced efflux has been described as the second mechanism of resistance in @entity794 . Acquired resistance to the @entity5176 was thought, until recently, to result from chromosomal mutation. Plasmid-mediated resistance associated with an enhanced efflux has been described in @entity794 , but this needs to be confirmed. When a high level of resistance is observed, 2 or 3 mechanisms may be involved.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Mechanisms of resistance to XXXX .

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino-acid']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus']

entities_list: @entity7660 :: ('MESH:D047090', 'Chemical') :: ['beta-lactams']

entities_list: @entity206 :: ('MESH:D014295', 'Chemical') :: ['trimethoprim']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

entities_list: @entity1536 :: ('CHEBI:23765', 'Chemical') :: ['quinolone']

answer: @entity5176 :: (MESH:D015363,Chemical) :: ['quinolones']


abstract: The search for effective and efficacious therapy for @entity96 was started many years ago and is still ongoing. Despite all of the surgical advances, much work needs to be done to improve understanding of the biology of the @entity5 and its treatment. The rules of hepatic surgery are changing because of two recent major trends: (1) technical simplification, and (2) the endeavor to treat an increasing number of @entity1 . T lymphocytes are potent cellular effectors of the immune system and possess a memory that responds to rechallenge by the same antigen. Being more specific and less toxic than chemotherapy, @entity5 infusion could be an ideal adjuvant therapy for @entity1 with primary and secondary liver @entity5 . Moreover, @entity5 cell vaccines have demonstrated efficacy in terms of minimal @entity66 and are being investigated, but the requirement for an adequate supple of autologos @entity5 may limit the general applicability of these approaches. Various studies have demonstrated the aberrant expression of germ-cell proteins called @entity5 ( @entity5 ) antigens in liver neoplastic cells. Their selective normal-tissue expression makes them ideal antigens for immune targeting of @entity5 . Specific expression of @entity5 antigens also suggests their application as @entity5 markers to detect circulating @entity157 ( @entity157 ) cells, as an adjuvant diagnostic tool, and as indicators for recurrence and prognosis. Biological therapy is now generating more clinical trials. More studies need to be performed and further experiments need to be done, although currently this seems a valid pathway for the treatment of @entity96 . Cytoreduction treatment of @entity96 and the vaccine might be the future of the treatment of primary and secondary @entity96 .

title: Biological treatment for XXXX and new potential biomarkers.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer', 'liver tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer-testis', 'malignant disease', 'CT', 'malignancies']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity96 :: (MESH:D008113,Disease) :: ['liver tumor']


abstract: Influenza A viruses infecting poultry can be divided into 2 groups. The extremely virulent viruses cause @entity1323 ( @entity1323 ), with flock mortality as great as 100%. These viruses have been restricted to subtypes H5 and H7, although not all H5 and H7 viruses cause @entity1323 . All other viruses cause a milder, primarily respiratory, disease (LPAI) unless exacerbated. Until recently, @entity1323 viruses were rarely isolated from wild birds, but for LPAI viruses, extremely great isolation rates have been recorded in surveillance studies. Influenza viruses may infect all types of domestic or captive birds in all areas of the world, with the frequency with which primary @entity281 occur in any type of bird usually depending on the degree of contact of the bird with feral birds. Secondary spread is usually associated with @entity1 involvement, either by bird or bird product movement, or by transferring infective feces from infected to susceptible birds, but potentially wild birds could be involved. In recent years, the frequency of @entity1323 outbreaks appears to have increased, and there have been particularly costly outbreaks of @entity1323 in densely populated poultry areas in Italy, the Netherlands, and Canada. In each, millions of birds were slaughtered to bring the outbreaks under control. Since the 1990s, avian influenza @entity281 attributable to 2 subtypes have been widespread in poultry across a large area of the world. The LPAI H9N2 virus appears to have spread across the whole of Asia in that time and has become endemic in poultry in many of the affected countries. However, these outbreaks have tended to be overshadowed by the H5N1 @entity1323 virus, which, although initially isolated in China, has now spread in poultry, wild birds, or both throughout Asia and into Europe and Africa, resulting in the death or culling of hundreds of millions of poultry and posing a significant zoonotic threat. To date, control methods seem to have been unsuccessful on the larger scale, and @entity1323 H5N1 outbreaks continue to be reported.

title: Avian XXXX in birds: a challenge and opportunity for the poultry veterinarian.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1323 :: ('MESH:D005585', 'Disease') :: ['highly pathogenic avian influenza', 'HPAI']

answer: @entity281 :: (MESH:D007239,Disease) :: ['influenza infection']


abstract: AIM: The aim of this study was to evaluate the relationship between serum @entity4093 ( @entity4093 ) level and neutrophil-lymphocyte ratio (NLR) with @entity7494 ( @entity7494 ). METHODS: Overall, 90 @entity1 who presented with pregnancy between August 2013 and November 2014 were included in the study. The @entity1 were divided into two groups: @entity1 with @entity7494 (n=45) and @entity1 without @entity7494 (control group [C]; n=45). The @entity1 with comorbid conditions other than pregnancy (disease or medication) were excluded. In all @entity1 , demographic data including age, body mass index (BMI), gestational week, and smoking status were recorded. Blood samples were drawn for complete blood count and measurements of blood lipid, liver enzymes, serum @entity4093 , and insulin levels. NLR was calculated from CBC. RESULTS: No significant differences were detected in age, BMI, or GA between groups (P>0.05). Serum @entity4093 and NLR were found to be significantly higher in @entity1 with @entity7494 compared with those in the control group (P=0.001 and 0.006, respectively). CONCLUSION: In @entity7494 , both @entity4093 level and NLR increased. In @entity7494 , this occurred as a response to metabolic alterations and potential @entity32 .

title: Is there any relationship between serum XXXX level and neutrophil-lymphocyte ratio in @entity7494 ?

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity7494 :: ('MESH:D006939', 'Disease') :: ['hyperemesis gravidarum', 'HG']

answer: @entity4093 :: (23411,Gene) :: ['sirtuin-1']


abstract: BACKGROUND: A retrospective analysis of clinical data were conducted reviewing @entity1 who were given @entity3866 at Peking Union Medical College (PUMC) Hospital from May 2005 to December 2009. Relationships between clinical factors, @entity470 ( @entity470 ) mRNA expression, @entity470 gene mutations, @entity984 gene mutations and clinical outcomes were investigated in Chinese @entity1 with advanced @entity1149 ( @entity1149 ). METHODS: @entity1 with stage IIIB/IV @entity1149 who had not previously participated in @entity3866 related clinical trials were enrolled into this study. All @entity1 were given oral @entity3866 150 mg per day. Tumor samples of some @entity1 were accessed with mutant-enriched polymerase chain reaction assay ( @entity470 , @entity984 gene mutations) and multiplex branched DNA assay ( @entity470 mRNA expression). RESULTS: Seventy-nine @entity1 were enrolled in this study, 23 @entity1 had a partial response (PR), 36 @entity1 had a @entity66 ( @entity66 ), 20 @entity1 had a @entity1726 , with an objective response rate of 29.1%, and a disease control rate of 74.7%. Females (P = 0.023), non-smokers (P = 0.013), @entity1 with a @entity1910 (P = 0.047), and with highly differentiated @entity5 (P = 0.037) were significantly correlated with the objective response rate. @entity1 with a lower ECOG PS (P = 0.002), highly differentiated @entity5 (P = 0.014), non-smokers (P = 0.002), and @entity1 with a @entity1910 (P < 0.001) were significantly correlated with the disease control rate. The median progression-free survival was 35 weeks (95%CI: 13 - 57 weeks) and 1-year survival was 72.3%. Highly-differentiated @entity5 (P = 0.027) and @entity1 with a @entity1910 (P < 0.001) were significantly correlated with PFS. Seventeen @entity1 were tested for @entity470 / @entity984 gene mutations and @entity470 mRNA expression. Progression-free survival (PFS) of @entity1 with @entity470 exon 19/21 mutations was 66 weeks, longer than @entity1 with wild type @entity470 exon 19/21 (P = 0.018). No significant relationships were found between @entity470 mRNA expression, @entity470 exon 19/21 mutations, and @entity984 mutations and objective response rate or disease control rate. The most common adverse events were @entity1910 (60.9%) and @entity294 (26.6%). CONCLUSIONS: @entity3866 was safe and effective in treating Chinese @entity1 with advanced @entity1149 . The PFS of @entity1 who had a @entity1910 , highly differentiated @entity5 , or @entity470 exon 19/21 mutations was significantly longer.

title: Efficacy and clinical/molecular predictors of @entity3866 monotherapy for Chinese advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['stable disease', 'SD']

entities_list: @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib', 'Erlotinib']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: OBJECTIVE: The Remission Evaluation and Mood Inventory Tool (REMIT) is a practical 5-item self-report measure of key positive mood states associated with recovering from @entity308 , as distinct from @entity308 per se. The study goal was to identify a clinically useful threshold for interpreting REMIT responses in the context of mild to moderate @entity308 . METHODS: This was a secondary analysis of a cross-sectional dataset initially used to develop and validate the REMIT. Primary care @entity1 being treated for @entity308 of either mild or moderate severity (n   =   247 and 240, respectively) rated their perceived degree of @entity308 remission prior to completing the @entity1 Health Questionnaire-8 (PHQ-8) and the REMIT. We summed the totals of the latter two measures to form the PHQ   +   REMIT index. RESULTS: Receiver Operating Characteristics analysis indicated that the PHQ   +   REMIT threshold >= 13 was associated with good sensitivity (92%) and acceptable specificity (43%) to the absence of @entity1 -perceived remission. In contrast, the PHQ had only 21% specificity at this sensitivity level. Area under the curve was 0.815 (95% C.I.: 0.765-0.865), which was significantly greater than that of the PHQ-8 alone (area under the curve   =   0.745, 95% C.I.: 0.691-0.805, p(diff)   =   0.0002). Threshold performance was unaffected by adjustment for demographic characteristics and variation in remission percentage. Compared with standard symptom-based classification, using the REMIT reclassified 27% of mildly symptomatic @entity1 as remitted. CONCLUSIONS: Using the REMIT with @entity1 who have mild to moderate @entity308 improves the assessment of @entity1 -perceived remission, which is indicated by a summed PHQ   +   REMIT index of less than 13. Longitudinal research is needed to test whether this broadened @entity1 -centered approach to assessing remission improves clinical decision making and long-term outcomes.

title: Improving the assessment of XXXX remission with the Remission Evaluation and Mood Inventory Tool.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: An account is given in this paper of 480 @entity1 who had been hospitalised for @entity6522 or @entity4436 in the surgical department of the Municipal Waid Hospital of Zurich, between 1970 and 1986. Laparotomy had to be performed on 219 of them (45.6 per cent), among them 84 emergency interventions. The average age of these @entity1 was 70.7 years. Indications for emergency surgery included diffuse or locally delimited @entity298 with abscess development in 72 @entity1 , ileus in ten cases, and massive @entity548 in two. The latter two cases were handled with good success by subtotal colectomy with ileorectostomy and, one of them with the source of @entity548 known, by colotomy and suturing of that source of @entity548 . Sigmaincontinence resection according to Hartmann has been considered the optional approach since 1977 to diffuse @entity298 and to many cases of ileus (n = 39). In more recent time, @entity254 has been used as primary approach to some @entity1 who survived fibrinous @entity298 (n = 4). The mortality rate associated with drainage operations according to expectation, has been clearly higher than that following resection, the comparable figures being 32.3 and 17.2 per cent. That has been attributable to non-removal of the septic focus. After all, nowadays combined antibiotic therapy is commonly used for seven to ten days for simultaneous control of both aerobic and anaerobic pathogens. This has become routine practice and involves @entity4028 , @entity868 , and @entity869 . Overall mortality associated with emergency interventions is clearly higher than that after planned operations, the figures being 22.6 and 4.4 per cent.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Emergency interventions in complicated XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['colon haemorrhage', 'bleeding']

entities_list: @entity6522 :: ('MESH:D043963', 'Disease') :: ['colonic diverticulosis']

entities_list: @entity4028 :: ('CHEBI:47779', 'Chemical') :: ['aminoglycoside']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity4436 :: ('MESH:D004238', 'Disease') :: ['diverticulitis']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['abdominal peritonitis', 'peritonitis']

answer: @entity6522 :: (MESH:D043963,Disease) :: ['colonic diverticulosis']


abstract: Employing immunoelectron microscopy with ultrathin frozen sections, intranuclear localization of hormone-occupied and -unoccupied @entity172 receptors (ER) was examined in the uterine epithelium; after 1 h of 17 @entity10769 (E2, 20 micrograms/kg b.w.) or saline intraperitoneal injection, adult ovariectomized @entity19 were sacrificed. ER were localized with both anti-ER monoclonal antibody and polyclonal antibody ( @entity5427 409) and 1 nm immunogold followed by @entity575 enhancement. No significant differences in ultrastructure were recognized in either the nuclei or the cytoplasm of the uterine epithelium in E2-treated and control animals. E2-occupied and -unoccupied ER showed the same distribution pattern in the nuclei of both luminal and glandular epithelium. ER were exclusively localized in the dispersed and slightly condensed chromatin; the margins of the condensed chromatin also showed strong immunoreaction. Little immunolabeling was observed in the highly condensed chromatin associated with nuclear membranes. The reaction was negative in the nucleoli. Both antibodies provided the same ER intranuclear localization. It is suggested that marked change in the distribution of @entity134 receptors, i.e. rapid translocation from condensed chromatin to dispersed chromatin or the margins of condensed chromatin as described in some previous reports, probably takes place as a consequence of conformational changes in the chromatin-binding receptors.

title: Intranuclear localization of hormone-occupied and -unoccupied @entity172 receptors in the @entity19 uterus: application of 1 nm immunogold- XXXX enhancement procedure to ultrathin frozen sections.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity10769 :: ('CHEBI:16469', 'Chemical') :: ['beta-estradiol']

answer: @entity575 :: (MESH:D012834,Chemical) :: ['silver']


abstract: The ability of @entity0 to synthesize hormones is well recognized, and local production of sex @entity230 is thought to play a role in @entity0 growth. We measured the intratumour and circulating levels of @entity251 , @entity586 ( @entity587 ) and @entity53 in 35 histologically confirmed @entity3909 mammary tissues obtained at breast surgery from 34 postmenopausal @entity1 , age 50-85 years. Intra-tissue @entity230 were extracted with @entity1068 : @entity1324 (1:1; v/v), defatted with 70% @entity1042 in water, and extracted with ether. @entity230 , from tissue and serum, were separated by partition chromatography on celite columns and were measured by RIA. Intratumour @entity251 and @entity587 concentrations were significantly correlated, after the exclusion of an outlier (rs = 0.71; P = 0.0001). No association was found between @entity53 and either of the two @entity3800 . Mean @entity53 and @entity587 concentrations were significantly higher in tissue than in blood (P = 0.0001). Mean @entity251 levels in tissues did not significantly differ from those measured in blood. Our data suggest that at least a part of intratissue @entity587 is produced locally from @entity251 . The meaning of high @entity53 and @entity587 levels in @entity5 tissue still needs to be defined.

title: XXXX , @entity586 and @entity53 levels in postmenopausal @entity0 tissues.

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast tumours', 'breast cancer']

entities_list: @entity586 :: ('MESH:D013196', 'Chemical') :: ['dihydrotestosterone']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol']

entities_list: @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids', 'steroids']

answer: @entity251 :: (MESH:D013739,Chemical) :: ['Testosterone']


abstract: @entity534 is metabolized by two pathways: 1) by @entity842 synthase (NOS) to @entity842 (NO) and 2) by arginase forming @entity1133 and @entity10608 . Inflammatory responses may involve a balance between the pathways, as NO is cytotoxic and vasodilatory and @entity10608 is a promoter of cell proliferation and matrix synthesis. In experimental @entity631 we have previously shown that NOS is activated in nephritic glomeruli. We have now examined both pathways of @entity534 metabolism to study competition for @entity534 , temporal variation, and the sources of NOS and arginase. Acute in situ @entity631 was induced in @entity35 , and glomeruli were studied at 1, 4, and 7 days. Both NOS and arginase activities were present. There was temporal variation: NOS activity was highest on day 1 and arginase activity on day 4; both declined by day 7. Competition between the pathways was demonstrated by increased urea synthesis in the presence of @entity7293 , an inhibitor of NOS. Measurement of NOS and arginase activities in macrophages isolated from nephritic glomeruli showed that these cells were a major source of glomerular NOS but not arginase activity. In contrast, high arginase activity but low NO production was identified in cultured @entity35 glomerular mesangial cells. These studies show differential temporal variation in expression of NOS and arginase pathways of @entity369 metabolism in experimental @entity631 . We have found two factors that may contribute to this: 1) competition for substrate @entity534 between the two pathways and 2) different cellular sources. We hypothesize that the balance between these pathways is a mechanism regulating injury, hemodynamics, and mesangial cell proliferation.

title: XXXX metabolism in experimental @entity631 : interaction between @entity842 synthase and arginase.

entities_list: @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine', 'L-Arginine']

entities_list: @entity7293 :: ('CHEBI:28229', 'Chemical') :: ['NG-monomethyl-L-arginine']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity10608 :: ('CHEBI:15729', 'Chemical') :: ['L-ornithine']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity369 :: (CHEBI:29016,Chemical) :: ['Arginine']


abstract: RATIONALE: Early exposure to stress and teratogenic substances have an impact on brain structures involved in cognition and mental health. While moderate-to-high levels of prenatal @entity167 exposure (PAE) have repeatedly been associated with long-term @entity245 , no consensus has yet been reached on the detrimental effects of low-to-moderate PAE on the @entity1 's functioning, including the @entity2339 . OBJECTIVES: The study aims to examine the association between low PAE and @entity701 response to unfamiliar situations in 19-month-old @entity1 and to determine whether this association was moderated by sex and @entity251 levels. METHODS: Information regarding PAE, @entity701 response to unfamiliar situations, and @entity251 activity was available in a total of 130 @entity1 participating to the Qu  bec Newborn Twin Study (Montr  al, QC, Canada). Mother @entity167 consumption during pregnancy was assessed via a semistructured interview conducted when the @entity1 were 6 months of age. The contribution of prenatal and postnatal confounds were examined. RESULTS: Disrupted patterns of @entity701 activity were observed only in PAE males. @entity251 tended to be negatively associated with the @entity701 response, but not for PAE males, suggesting an altered sensitivity to the inhibitory effects of @entity251 in these @entity1 . CONCLUSIONS: Low levels of PAE were associated with disrupted @entity701 activity, and males may be at higher risk. These findings challenge the existence of a "safe level" of @entity167 consumption during pregnancy and have public health implications.

title: Prenatal @entity167 exposure and @entity701 activity in 19-month-old toddlers: an investigation of the moderating effects of sex and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental deficits']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['limbic-hypothalamic-pituitary-adrenal axis']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

answer: @entity251 :: (MESH:D013739,Chemical) :: ['testosterone']


abstract: @entity4037 repair (LVHR) is widely used to manage @entity4037 , but predictors of @entity547 have been poorly investigated. This retrospective study investigated the influence of common risk factors on @entity547 . Data from 146 consecutive, unselected @entity1 who underwent LVHR between 2000 and 2006 were collected. Demographic, clinical, and perioperative parameters were analyzed to identify predictable risk factors for @entity547 . Both univariate and multivariate Cox's regression analysis were employed. The overall recurrence rate was 8% (12 @entity1 ) after an average follow-up of 45 months. On univariate analysis, smoking (P=0.01) and earlier repair (P<0.00) were significantly different in recurred @entity1 . However, only earlier repair was an independent predictor of multivariate Cox's regression analysis (hazard ratio 0.085, 95% confidence interval: 0.020-0.355; P=0.001). LVHR is a safe technique to repair @entity4037 . However, smokers with earlier failed repair attempts have a higher risk of recurrence.

title: Predictors of recurrence after XXXX repair.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4037 :: ('MESH:D006555', 'Disease') :: ['Laparoscopic ventral hernia', 'ventral hernias']

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia recurrence']

answer: @entity4037 :: (MESH:D006555,Disease) :: ['laparoscopic ventral hernia']


abstract: Cryptic trehalase from @entity375 was purified about 3000-fold. The recovery of 970% of the original "activity" indicated the removal of an inhibitor of the enzyme. Active trehalase, obtained through phosphorylation of cryptic trehalase by @entity268 -dependent protein kinase, was isolated by chromatography on DEAE-cellulose. A major phosphorylated protein, with an apparent Mr of 86,000, was detected after @entity214 - @entity2975 gel electrophoresis. This protein band correlated exactly with the elution profile of trehalase activity and 32Pi incorporation into the enzyme on @entity8851 -cellulose chromatography. Partially purified active trehalase showed absolute specificity towards @entity7970 with an apparent Km of 4.79 X 10(-3) M. Both forms of the enzyme showed an apparent molecular weight of 160,000, by gel filtration. Centrifugation on a @entity653 density gradient indicated multiple forms of trehalase-c, with Mr of 320,000, 160,000, and 80,000. After activation of each of these forms by protein kinase, a single form of trehalase-a was observed, with a Mr of 160,000. Trehalase-c appears to be a totally inactive form of the enzyme. The only mechanism of activation seems to be phosphorylation by @entity268 -dependent protein kinase. When the protein kinase concentration was varied, at a fixed trehalase-c concentration, a sigmoidal activation plot was obtained. This result suggests the occurrence of multiple forms of cryptic trehalase.

title: Partial purification and characterization of the interconvertible forms of trehalase from XXXX .

entities_list: @entity7970 :: ('MESH:D014199', 'Chemical') :: ['trehalose']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['Saccharomyces cerevisiae']