abstract: PURPOSE: This planned exploratory analysis assessed the predictive nature of baseline circulating factors of the insulin-like growth factor (IGF) @entity2270 on the treatment effect of ganitumab (monoclonal antibody inhibitor of @entity442 receptor) plus @entity136 in a randomized phase II study in metastatic @entity788 . EXPERIMENTAL DESIGN: Baseline levels of IGFs/IGF binding proteins (IGFBP) were analyzed in serum or plasma. Mutations and gene expression were analyzed in archival samples. Treatment effects between biomarker subgroups were compared for @entity1349 ( @entity1349 ). Associations of @entity5 markers with @entity1349 were evaluated. RESULTS: For @entity1 with evaluable samples, ganitumab was associated with improved @entity1349 versus placebo (HR, 0.49; 95% CI: 0.28-0.87). The treatment effect on improved @entity1349 was strong in the @entity1 subset with higher levels of @entity442 , @entity5100 , or @entity2301 , or lower levels of @entity10513 , but not so on the other corresponding subset. Median @entity1349 of ganitumab versus placebo in @entity1 with higher levels of @entity442 , @entity5100 , and @entity2301 was 16 versus 6.8 months (HR, 0.25; 95% CI: 0.09-0.67), 16 versus 5.9 months (HR, 0.24; 95% CI: 0.09-0.68), and 16 versus 6.8 months (HR, 0.28; 95% CI: 0.11-0.73), and in @entity1 with lower @entity10513 levels was 12.7 versus 6.6 months (HR, 0.19; 95% CI: 0.07-0.55). Interaction between treatment and IGFs/IGFBPs in multivariate analyses suggested predictive potential for @entity5100 (P = 0.002) and @entity10513 (P = 0.02). @entity984 mutation status and @entity983 expression were not associated with @entity1349 . CONCLUSIONS: Baseline circulating factors of the IGF @entity2270 may predict @entity1349 benefit from ganitumab plus @entity136 in metastatic @entity788 .

title: Putative predictive biomarkers of survival in @entity1 with metastatic @entity788 treated with XXXX and ganitumab, an IGF1R inhibitor.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity136 :: (MESH:C056507,Chemical) :: ['gemcitabine']


abstract: OBJECTIVES: Our goal was to determine long-term efficacy and safety of B-cell-depletion therapy for @entity1 with @entity3039 and @entity5506 in @entity1252 . @entity1 AND METHODS: A retrospective, single-center cohort study was conducted including all @entity1 with @entity1252 who were diagnosed with @entity3039 and/or @entity5506 and treated with rituximab. Treatment efficacy and safety parameters were monitored and recorded. RESULTS: Nine @entity1 with @entity1252 were included in the study: 5 had @entity3039 , 3 had @entity5506 , and 1 had both. There were 5 female and 4 male @entity1 ; median age at diagnosis of @entity1252 was 14 years (range: 8-16 years); and median @entity1252 disease duration to time of rituximab treatment was 6 months (range: 2-30 months). Complete response was achieved in all 6 @entity1 with @entity3039 (median time to complete response: 2 weeks [range: 1-12 weeks]). Two @entity1 ' conditions flared at 48 and 68 weeks, respectively, and were re-treated. The remaining 4 @entity1 continued to be in remission at 24, 32, 36, and 88 weeks, respectively. All 4 @entity1 with @entity5506 achieved complete response at a median time of 4 weeks (range: 4-32 weeks). All @entity1 remained in complete response at 24, 44, 84, and 100 weeks of follow-up. Complete B-cell depletion was seen in all @entity1 after rituximab treatment. No serious @entity281 occurred, but 1 @entity1 had an infusion reaction. CONCLUSIONS: Preliminary evidence suggests that B-cell-depletion therapy with rituximab is an efficacious and safe treatment for @entity3039 and @entity5506 in @entity1252 . Despite the prolonged effect on B-cell numbers and function, no serious @entity281 were observed.

title: B-cell depletion for @entity3039 and XXXX in @entity1252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'PATIENTS']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['pediatric systemic lupus erythematosus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity5506 :: ('MESH:D000744', 'Disease') :: ['autoimmune hemolytic anemia']

entities_list: @entity3039 :: ('MESH:D016553', 'Disease') :: ['autoimmune thrombocytopenia']

answer: @entity5506 :: (MESH:D000744,Disease) :: ['autoimmune hemolytic anemia']


abstract: BACKGROUND: @entity731 is an age-related disease. @entity1254 and @entity6300 form a protein complex in @entity1 blood, and that serum @entity6300 and @entity6300 -binding @entity1254 ( @entity6300 - @entity10793 ) concentrations can be measured. We investigated circulating @entity6300 and @entity6300 - @entity10793 levels in Japanese @entity1 including elderly @entity1 . FINDINGS: The study subjects were 509 Japanese @entity1 including elderly men. Serum levels of total @entity1254 (Total- @entity10793 ), high-molecular weight- @entity1254 (HMW- @entity10793 ), @entity6300 - @entity10793 and @entity6300 were measured by enzyme-linked immunosorbent assay. Total- @entity10793 , HMW- @entity10793 and @entity6300 - @entity10793 , but not @entity6300 , correlated significantly and positively with aging (r=0.26, r=0.24, r=0.17, p<0.01, respectively). The HMW- @entity10793 /Total- @entity10793 ratio correlated significantly and positively with aging (r=0.14, p<0.01). The @entity6300 - @entity10793 /Total- @entity10793 ratio and @entity6300 - @entity10793 /HMW- @entity10793 ratio correlated significantly and negatively with aging (r=-0.17, p<0.01, r=-0.12, p=0.01). @entity6300 - @entity10793 / @entity6300 correlated significantly and positively with aging (r=0.09, p=0.03). Multiple regression analysis identified age and body mass index as significant determinants of @entity6300 - @entity10793 . CONCLUSIONS: The present study demonstrates that serum HMW- @entity10793 , @entity6300 - @entity10793 , and Total- @entity10793 , but not @entity6300 , correlated positively with aging. These preliminary results could form the basis for future research. TRIAL REGISTRATION:                 <AbstractText Label="CLINICAL TRIAL REGISTRATION NUMBER" NlmCategory="BACKGROUND">UMIN000004318.

title: Correlation of circulating @entity6300 and @entity6300 -binding XXXX concentrations with aging in males: a preliminary report.

entities_list: @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis']

answer: @entity1254 :: (9370,Gene) :: ['adiponectin']


abstract: PURPOSE: @entity1358 ( @entity1358 ) is a rare histologic subtype that demonstrates poor outcomes in @entity43 . The Japanese Gynecologic Oncology Group conducted the first randomized phase III, @entity1358 -specific clinical trial that compared @entity2600 and @entity900 ( @entity1191 -P) with @entity1311 plus @entity3003 (TC) in @entity1 with @entity1358 . @entity1 AND METHODS: Six hundred sixty-seven @entity1 with stage I to IV @entity1358 of the ovary were randomly assigned to receive @entity2600 60 mg/m(2) on days 1, 8, and 15 plus @entity900 60 mg/m(2) on day 1 (CPT-P group) every 4 weeks for six cycles or @entity1311 175 mg/m(2) plus @entity3003 area under the curve 6.0 mg/mL/min on day 1 every 3 weeks for six cycles (TC group). The primary end point was progression-free survival. Secondary end points were overall survival, overall response rate, and adverse events. RESULTS: Six hundred nineteen @entity1 were clinically and pathologically eligible for evaluation. With a median follow-up of 44.3 months, 2-year progression-free survival rates were 73.0% in the CPT-P group and 77.6% in TC group (hazard ratio, 1.17; 95% CI, 0.87 to 1.58; P = .85). Two-year overall survival rates were 85.5% with CPT-P and 87.4% with TC (hazard ratio, 1.13; 95% CI, 0.80 to 1.61; one-sided P = .76). Grade 3/4 @entity448 , @entity294 , @entity390 , @entity391 , and @entity1398 occurred more frequently with CPT-P, whereas grade 3/4 @entity1431 , @entity1398 , @entity882 , @entity1897 , and joint @entity158 occurred more frequently with TC. CONCLUSION: No significant survival benefit was found for CPT-P. Both regimens were well tolerated, but the @entity137 profiles differed significantly. Treatment with existing anticancer agents has limitations to improving the prognosis of @entity1358 .

title: Randomized Phase III Trial of @entity2600 Plus @entity900 Compared With @entity1311 Plus XXXX As First-Line Chemotherapy for @entity43 : JGOG3017/GCIG Trial.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['epithelial ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['Clear cell carcinoma', 'CCC']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'febrile neutropenia']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral sensory neuropathy']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['Carboplatin']


abstract: INTRODUCTION: The optimal management of WHO grade II @entity11 (GIIG) is currently one of the most controversial issues in neuro-oncology. AIM: This paper discusses the most controversial aspects of management of these @entity5 , based on a review of the literature of the last 20 years. DEVELOPMENT: @entity1 with GIIG often suffer @entity73 that go unnoticed in daily clinic, which significantly affect the quality of life. These @entity5 do not remain stable, as they grow slowly and steadily. In fact, growth rate is a reliable marker of their biological behaviour, with rapid growth being a marker of @entity5 . Current neuro-imaging studies and stereotactic biopsy are not reliable enough for diagnosis of GIIG, thus many authors consider that a definitive diagnosis can only be obtained with a detailed histological examination after extensive surgical resection. An increasing number of studies support the prognostic impact of surgery, as it delays malignant transformation and increases survival. GIIG are frequently located in eloquent brain areas; intraoperative electrical stimulation mapping is now considered the gold standard to remove these @entity5 with a low risk of sequelae. CONCLUSIONS: There is growing scientific evidence against a 'wait-and-see' management of GIIG. Surgery is considered nowadays by most authors as the first step in the diagnosis and treatment of these @entity5 .

title: [Controversial aspects in WHO grade II XXXX management: review of recent literature].

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and emotional disorders']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumors']

answer: @entity11 :: (MESH:D005910,Disease) :: ['gliomas']


abstract: @entity45903 , an uncharged @entity167 contained in Atractylodes lancea, blocks the neuromuscular junction. Atractylodes lancea is prescribed in a traditional Chinese medicine and plays a main role for "alleviation of @entity925 ". By using the cell-attached patch-clamp or conventional intracellular technique, the site of action of @entity45903 on the nicotinic @entity934 ( @entity1617 ) receptor ( @entity15683 ) channel in skeletal muscle of the adult @entity19 , was investigated and compared with that of different types of blockers of the nicotinic @entity1617 receptor channel ( @entity1341 , @entity2644 and @entity12781 ). @entity45903 (200 microM) depressed completely the nerve-evoked twitch tension and reduced the amplitude and quantal size of endplate potentials but did not alter either the quantal content, resting membrane potential or action potential. @entity45903 (100-200 microM) decreased the amplitude of @entity1617 potentials and accelerated the slow decay of depolarization, induced by the continuous application of @entity1617 . @entity45903 (40 microM) and @entity12781 (10 microM) decreased both the open time and opening frequency, without affecting the single channel conductance. @entity1341 (10 microM) decreased only the open time. @entity2644 (10 microM) decreased only the opening frequency. These results indicate that the blocking effect of @entity45903 on nerve-evoked contraction, was due to blockade of nicotinic @entity1617 receptor channels at the neuromuscular junction. Like @entity12781 , @entity45903 blocked the nicotinic @entity1617 receptor channel in both the open and closed conformations, and accelerated the desensitization of the nicotinic @entity1617 receptor.

title: Mechanism of the blocking action of @entity45903 on the nicotinic XXXX receptor channel in @entity19 skeletal muscles.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity12781 :: ('MESH:D010622', 'Chemical') :: ['phencyclidine']

entities_list: @entity45903 :: ('MESH:C051082', 'Chemical') :: ['beta-Eudesmol', 'beta-eudesmol']

entities_list: @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine', 'Chlorpromazine']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine', 'Bupivacaine']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['pain in skeletal muscle']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity934 :: (MESH:D000109,Chemical) :: ['acetylcholine']


abstract: @entity900 / @entity2879 / @entity1732 ( @entity16905 ) was given as an outpatient regimen in a novel weekly schedule to 27 @entity1 with recurrent and/or widely metastatic @entity135 region. Six of these @entity1 also received @entity1138 (DEB/M) when their disease failed to respond after at least three weekly DEB doses. All but three @entity1 had been treated previously with radiotherapy directed to the primary site and regional nodal disease; four had also received chemotherapy with @entity900 or @entity3003 . Before treatment with DEB, 19 @entity1 had distant metastases. Of an intended 12 doses per @entity1 , a mean of 8.2 was achieved. Myelosuppression was the major @entity137 , with @entity1398 in 45% of @entity1 and significant @entity417 in 26%. The overall response rate to DEB in 27 @entity1 was 59%, increasing to 70% after the addition of @entity1138 . There were two complete and 17 partial responses. The median duration of response was 12 weeks and median survival was 6 months, with 20% of @entity1 surviving 1 year. We conclude that the relatively short survival time together with the significant @entity137 of the DEB/M regimen does not warrant its routine use in clinical practice. However, this regimen, or one patterned on it, should be evaluated in combination with radiotherapy as the initial treatment for selected @entity1 with previously untreated @entity135 .

title: Treatment of recurrent and metastatic @entity135 with XXXX / @entity2879 / @entity1732 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'cancer of the head and neck']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: PURPOSE: We describe a technical artifice facilitating nephron sparing surgery for @entity1358 without clamping the renal pedicle. MATERIALS AND METHODS: Selective renal parenchymal clamping was performed using a large curved DeBakey aortic clamp placed around and sufficiently far from the @entity5 . The lesion was resected with a surrounding margin of normal renal parenchyma. The intrarenal vessels were suture ligated and the collecting system was closed as necessary. Time was not limited since the artery was not clamped. RESULTS: Ten @entity1 with @entity1358 in whom nephron sparing surgery was indicated underwent selective renal parenchymal clamping. The indication was elective in 8 @entity1 and urgent in 2. The @entity5 was at the renal pole in 3 cases and peripheral in 7. Mean @entity5 size was 32 mm. (range 19 to 52). @entity190 was insignificant. Operative time was 81 minutes (range 61 to 125) and there were no perioperative or @entity260 . CONCLUSIONS: Selective renal parenchymal clamping is a simple and efficient technical maneuver for facilitating nephron sparing surgery without pedicle dissection and clamping for renal peripheral or pole @entity5 . @entity5 location and size are the limiting factors of this technique.

title: Nephron sparing surgery for XXXX using selective renal parenchymal clamping.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Neoplasm', 'tumors']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['Blood loss']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']


abstract: Hokkaido @entity16745 ( @entity16745 yesoensis) are seasonal breeders and the profile of their serum @entity251 concentrations undergoes annual changes. However, precise sites of steroidogenesis in the bear testis have not been identified. Therefore, our objective was to localize steroidogenic enzymes by immunocytochemistry using polyclonal antibodies generated against steroidogenic enzymes of @entity1 origin. The steroidogenic enzymes localized were @entity165 side-chain cleavage cytochrome P450 (P450scc), @entity1816 dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase cytochrome P450 (P450c17), and aromatase cytochrome P450 (P450arom) as biosynthetic sites of @entity3333 , @entity1420 or @entity2671 , @entity3800 , and @entity172 , respectively. Testes were collected from three adult bears prior to the mating season (April, Hokkaido, Japan) and prepared for immunostaining with primary antibodies, followed by an avidin- @entity1885 -peroxidase method. P450scc was localized in Leydig cells and spermatids. 3 beta-HSD was found only in Leydig cells. P450c17 was identified in Leydig cells and spermatids. Finally, P450arom was found in Leydig cells and in spermatids that stained very intensely. Therefore, Leydig cells appear to be a site of @entity1871 (both delta 4 and delta 5 C21 @entity230 ), @entity342 , and @entity172 production, whereas spermatids appear to be a site of @entity3333 , @entity342 , and @entity172 production. Immunolocalization of steroidogenic enzymes suggests that steroidogenesis may occur not only in Leydig cells, but also in spermatids of the Hokkaido @entity16745 testis prior to the mating season. We also suggest that Leydig cells and spermatids are the predominant sites of @entity342 and @entity172 synthesis, respectively, in the Hokkaido @entity16745 testis.

title: Immunolocalization of steroidogenic enzymes, P450scc, 3 beta-HSD, P450c17, and P450arom in the Hokkaido @entity16745 ( XXXX yesoensis) testis.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity3333 :: ('MESH:D011284', 'Chemical') :: ['pregnenolone']

entities_list: @entity1816 :: ('CHEBI:36836', 'Chemical') :: ['3 beta-hydroxysteroid']

entities_list: @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']

entities_list: @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']

entities_list: @entity16745 :: ('9644', 'Species') :: ['brown bears', 'brown bear', 'Ursus arctos']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity16745 :: (9644,Species) :: ['Ursus arctos']


abstract: Blast wave-induced @entity130 from terrorist explosive devices can occur at any time in either military or civilian environments. To date, little work has focused on the central nervous system response to a non-penetrating @entity3614 . We have evaluated the effect of a single 80-psi blast-overpressure wave in a @entity35 model. Histological and immunochemical studies showed an early inflammatory response, tissue damage and the initiation of apoptosis. With @entity32 , polymorphonuclear leukocytes and lymphocytes infiltrated brain parenchyma within 1   h post-blast. Glial-fibrillary protein, cyclo-oxygenase-2ir, @entity3426 and @entity5 necrosis factor were present by 1   h and remained detectable at three weeks post-injury. High mobility group box-1 protein was detectable at three weeks. With regard to tissue damage, @entity21078 and 4-hydroxynonenal were present at 1   h and remained detectable at three weeks. Amyloid precursor protein was detectable at three weeks. As for apoptosis, Cleaved Caspase-3 was detectable at three weeks. Morris water maze assessment of cognitive function showed that blast injured animals required significantly more time to reach the platform on day 1 of training and traveled a greater distance to get to the platform on days 1 and 2. Blast-injured animals showed a significant increase in swimming speed (p<0.001), increased total distance traveled (p<0.001) and increased number of entries into the previous quadrant that had contained the escape platform (p<0.05). Magnetic resonance imaging showed hyperintense regions in the somatosensory area within 1   h. T2 relaxation times and apparent diffusion coefficients show increasing trends in both somatosensory and cortical regions. These data indicate an early and lasting response of brain tissue to non-penetrating blast over-pressure injury. This early inflammatory response is indicative of a mild @entity131 . There is evidence of early @entity75 .

title: Brain injury: XXXX , cognitive deficit, and magnetic resonance imaging in a model of blast induced @entity131 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['regard to inflammation']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity3614 :: ('MESH:D001753', 'Disease') :: ['blast injury']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['hippocampal dysfunction']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury']

answer: @entity32 :: (MESH:D007249,Disease) :: ['neuro-inflammation']


abstract: Gender differences in brain structure and function may lead to differences in the clinical expression of @entity16 , including @entity191 ( @entity191 ). Few studies reported gender-related differences in the burden of @entity1109 ( @entity1109 ) in treated @entity191 @entity1 , but this matter has not been previously explored in drug-na  ve @entity191 @entity1 . This study is to assess gender differences in the prevalence of @entity1109 in a large sample of early, drug-na  ve @entity191 @entity1 compared with age and sex-matched healthy controls. Two hundred early, drug-na  ve @entity191 @entity1 and ninety-three age and sex-matched healthy controls were included in the study. Frequency of @entity1109 was evaluated by means of the Non-Motor Symptoms Questionnaire. The difference in gender distribution of @entity1109 was evaluated with the    (2) exact test; multiple comparisons were corrected with the Benjamini-Hochberg method. Male @entity191 @entity1 complained of problems having sex and taste/smelling difficulties significantly more frequently than female @entity191 @entity1 . Furthermore, @entity1 with @entity191 complained more frequently of dribbling, sadness/blues, loss of interest, @entity148 , acting during dreams, and taste/smelling difficulties as compared to healthy control @entity1 , while female @entity191 @entity1 reported more frequently loss of interest and @entity148 as compared with healthy control @entity1 . This study shows specific sex-related patterns of @entity1109 in drug-na  ve @entity191 . In contrast with previous data, female @entity191 @entity1 did not present higher prevalence of mood symptoms as compared to male @entity191 @entity1 . Comparison with healthy controls showed that some @entity1109 classically present in premotor and early stage of disease (i.e., acting out during dreams, taste/smelling difficulties) are more frequent in male than in female @entity1 .

title: Gender differences in @entity1109 in early, drug na  ve XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['NMS', 'non-motor symptoms']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: AIMS AND BACKGROUND: @entity1 treated for @entity978 with chemotherapy or with the association of chemotherapy and radiotherapy have an increased risk of @entity1778 . The aim of this study was to evaluate the leukemogenic risk due to these treatment modalities. METHODS: We performed a case-control study on a population of 1410 @entity1 treated for @entity978 from 1970 to 1990 in our Institute. Among these @entity1 , we identified 25 cases of @entity1778 and 3 cases of @entity2590 , all occurring more than one year after the diagnosis of @entity978 . Three cases occurred among the @entity1 treated with radiotherapy alone. When we analyzed the risk in relation to the type of treatment (radiotherapy, chemotherapy, or both), the comparisons were relative to @entity1 treated with radiotherapy alone. RESULTS: We found that chemotherapy alone is associated with a fivefold increased risk (odds ratio = 5.4) compared with radiotherapy alone. When both treatments are used, the risk is not further increased (odds ratio = 4.4). @entity1 receiving more than 6 courses of chemotherapy have an excess risk (relative risk = 2.5) compared with those treated with 6 courses or less. No increased risk was observed after splenectomy. CONCLUSIONS: This study confirms an increased incidence of @entity1778 occurring in @entity1 treated for @entity978 . The increased risk seems to be correlated with the number of courses of alkylating agent therapy, whereas it is unaffected by the addition of radiotherapy.

title: @entity1778 following treatment for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['secondary leukemia']

entities_list: @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplasia']

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']


abstract: The effect of @entity32 , induced in @entity35 by injection of @entity18409 oil, on drug disposition has been evaluated in @entity35 isolated perfused livers. The drugs studied were a low extraction drug, @entity4591 , and two high extraction drugs, @entity3303 and @entity1169 . @entity18409 significantly increased the half-life of @entity4591 and of @entity1169 , but not that of @entity3303 . @entity48341 (SKF 525A) significantly increased the half-life of all three drugs. @entity18409 decreased the clearance of @entity4591 significantly by about 50% and that of @entity1169 non-significantly by about 20%, but did not affect the clearance of @entity3303 . @entity48341 significantly decreased the clearance of all three drugs, but this was most pronounced for @entity4591 . In both @entity18409 - and @entity48341 -treated @entity35 a significant increase in volume of distribution of @entity1169 was observed. The results show that, as with @entity48341 , @entity18409 -induced @entity32 affects the hepatic clearance of @entity4591 in the @entity35 isolated perfused liver. With both high extraction drugs, the effect of @entity32 on their clearance was low or absent, in contrast to the effect of @entity48341 . This suggests that a possible effect of @entity32 on intrinsic clearance is not large enough to influence the hepatic clearance of the high extraction drugs.

title: Effect of @entity32 and @entity48341 on the disposition of XXXX , @entity3303 and @entity1169 in @entity35 isolated perfused liver.

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity18409 :: ('MESH:D014425', 'Chemical') :: ['turpentine', 'Turpentine']

entities_list: @entity48341 :: ('MESH:D011335', 'Chemical') :: ['proadifen', 'Proadifen']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lignocaine']

entities_list: @entity4591 :: ('MESH:D000983', 'Chemical') :: ['antipyrine']

answer: @entity4591 :: (MESH:D000983,Chemical) :: ['antipyrine']


abstract: We previously established an 80 kb haplotype upstream of @entity16348 as a susceptibility locus in the autoimmune disease @entity1252 . @entity1252 -associated alleles at this locus are associated with @entity32 , including @entity731 and @entity64 . In Europeans, the @entity16348 causal variants have remained elusive due to strong linkage disequilibrium exhibited by alleles spanning the region. Using a trans-ancestral approach to fine-map the locus, utilising 17,900 @entity1252 and control subjects including Amerindian/Hispanics (1348 cases, 717 controls), African-Americans (AA) (1529, 2048) and better powered cohorts of Europeans and East Asians, we find strong association of risk alleles in all ethnicities; the AA association replicates in African-American Gullah (152,122). The best evidence of association comes from two adjacent markers: @entity47098 -T (P=1.71 * 10(-34) , OR=1.43[1.26-1.60]) and @entity47099 -T (P=1.16 * 10(-28) , OR=1.38[1.24-1.54]). Inference of fine-scale recombination rates for all populations tested finds the 80 kb risk and non-risk haplotypes in all except African-Americans. In this population the decay of recombination equates to an 11 kb risk haplotype, anchored in the 5' region proximal to @entity16348 and tagged by @entity47098 -T after 1000 Genomes phase 1 (v3) imputation. Conditional regression analyses delineate the 5' risk signal to @entity47098 -T and the independent non-risk signal to @entity47100 -C. Our case-only and @entity1252 -control cohorts demonstrate robust association of @entity47098 -T with autoantibody production. The @entity47098 -T is predicted to form part of a decameric motif which binds NF-kBp65 with increased affinity compared to @entity47098 -G. ChIP-seq data also indicate NF-kB interaction with the DNA sequence at this position in LCL cells. Our research suggests association of @entity47098 -T with @entity1252 across multiple groups and an independent non-risk signal at @entity47100 -C. @entity47098 -T is associated with autoantibody production and @entity2905 . Our data confirm a global signal at @entity16348 and a role for the expressed product at multiple stages of lymphocyte dysregulation during @entity1252 pathogenesis. We confirm the validity of trans-ancestral mapping in a complex trait.

title: Trans-ancestral studies fine map the XXXX -susceptibility locus @entity16348 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disorders']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke']

entities_list: @entity2905 :: ('MESH:D008231', 'Disease') :: ['lymphopenia']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['SLE']


abstract: There is a desperate need for preserved @entity1 arteries to be transplanted in infected areas of ischemic lower limbs. Cryopreserved arteries are fragile evoking strong allogeneic reactions. We have been searching for a preservation method that spares arterial wall structure and decreases its antigenicity. LEW and BN @entity35 segments of aorta were harvested, immersed in pulverized dehydrated @entity2827 , and stored for 1 week to 3 months. Thereafter, they were desalinated and transplanted side-to-side to the abdominal aorta and side-to-side to the aorta-IVC ( @entity292 ). We performed staining for actin, elastic fibers, collagen (trichrome), @entity2279 , endothelial cells (HIS52), MHC class II. Popliteal lymph node reactions were tested after subcutaneous implantation of an aortic fragment into the paw. We measured tensile strength and maximum intraluminal pressures. The preserved fragments of syngeneic aorta retained their cellular, stromal, and molecular structures. After transplantation, they did not evoke any reaction around the graft. The allogeneic fragments brought about only minor recipient responses, remaining patent and pulsatile for 3 months. The tensile strength and maximum intraluminal pressures did not significantly differ from freshly harvested, transplanted aortic segments.

title: Preservation of molecular structure of arterial grafts in pulverized XXXX : an experimental study.

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['AV fistula']

entities_list: @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']

answer: @entity2827 :: (MESH:D012965,Chemical) :: ['sodium chloride']


abstract: BACKGROUND: @entity1118 ( @entity1118 ) is a common symptom in @entity1 with @entity29 . This study aimed to examine its prevalence, severity, clinical associations, and impact on psychological well-being and to identify @entity1 factors that independently predict the presence of severe/disabling @entity158 . METHODS: One hundred and twenty consecutive @entity1 with @entity29 attending a hospital-based clinic provided information through questionnaires on quality of life, @entity1316 , and functional gut symptoms. Those who had @entity1118 ( @entity158 occurring every day for 3 months within the past 6 months) provided additional information on the @entity158 's intensity and associated disability and management and coping strategies. RESULTS: Forty-six @entity1 (38%) had @entity1118 , most commonly in the abdomen (91%), and they had higher disease activity, reduced quality of life, and more @entity308 and @entity148 and took more @entity1443 and opiates than those without. These indices were worse in the subgroup of 23 with moderate-severe @entity158 /disability. Criteria for @entity1744 were met in 70% of those with @entity158 irrespective of its severity. Multivariate analysis identified 4 independent associations with moderate-severe @entity158 /disability: active disease (odds ratio, 49 [95% confidence intervals, 1.6-1455]), catastrophizing tendency (35 [3-228]), medication belief score (0.05 [0.005-0.55], and @entity308 score (1.80 [1.02-3.17]). CONCLUSIONS: @entity1118 has major effects on quality of life and functional and social outcomes. @entity66 and maladaptive coping strategies and negative attitudes and beliefs toward symptoms are independently associated with more severe @entity158 . Management strategies should move the focus away from analgesic dependence toward psychosocial intervention and nonpharmacologic therapy.

title: XXXX in @entity29 : characteristics and associations of a hospital-based cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Active disease']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disturbance']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic pain', 'CP']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['Chronic pain']


abstract: 1. There is controversy about whether @entity20937 receptors mediate contraction of isolated cerebral blood vessels. We have therefore compared the vascular actions of the @entity20937 agonist, @entity10097 ( @entity10097 ) with those of the 5-HT1-like receptor agonist, @entity9251 , on the @entity235 isolated saphenous vein, which contains a 5-HT1-like receptor similar to those on cerebral blood vessels, and in the carotid circulation of the anaesthetized @entity235 . 2. @entity750 ( @entity750 ), @entity9251 and @entity10097 each caused contraction of @entity235 isolated saphenous vein with a rank order of agonist potency of @entity750 greater than @entity9251 greater than @entity10097 and EC50 values (95% confidence limits) of 0.06 (0.04-0.08), 0.3 (0.1-0.8) and 3.9 (2.0-7.5) microM respectively. The maximum contractile effect produced by each agonist was similar. 3. The contractile effects of @entity750 , @entity9251 and @entity10097 in the @entity235 isolated saphenous vein were resistant to antagonism by the @entity20937 antagonists @entity11054 , @entity50218 and @entity7690 (all 1 microM). The @entity20939 receptor ligands, @entity6521 (0.1 microM) rauwolscine (1 microM) and @entity3160 (1 microM) had little or no antagonist activity. In contrast, the non-selective 5-HT1-like receptor blocking drug, @entity10896 (0.03-0.3 microM) potently antagonized the contractile effects of @entity750 , @entity9251 and @entity10097 to a similar degree, suggesting that all three agonists act at the same receptor. 4. In ganglion-blocked, anaesthetized @entity235 , intra-carotid administration of @entity10097 (0.3-3 pggkg-1) and @entity9251 (0.1l-1 pgkg -), caused dose-dependent carotid arterial vasoconstriction. The two agonists were approximately equipotent in this respect. 5. The carotid arterial vasoconstrictor actions of @entity10097 and @entity9251 were not modified by @entity11054 (1 mgkg- , i.v.) but were antagonized to a similar extent by the subsequent administration of @entity10896 (1 mgkg- 1, i.v.). 6. These results suggest that @entity10097 contracts the @entity235 isolated saphenous vein and constricts the carotid arterial circulation of anaesthetized @entity235 by activation of 5-HT1-like receptors which are not of the 5-HTlA subtype, nor, on the basis of data with @entity6521 in the @entity235 isolated saphenous vein, of the 5-HTID subtype. The receptor involved in these actions appears to be the same as that mediating the vasoconstrictor effects of @entity9251 . This receptor does not appear to be like any known 5-HT1 ligand binding site; hence the current description, 5-HT1-like, remains the most appropriate.

title: Vascular 5-HT1-like receptors that mediate contraction of the @entity235 isolated saphenous vein and carotid arterial vasoconstriction in anaesthetized @entity235 are not of the XXXX or @entity20939 subtype.

entities_list: @entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine']

entities_list: @entity10097 :: ('MESH:D017371', 'Chemical') :: ['8-hydroxy-2-(di-n-propyl-amino)-tetralin', '8-OH-DPAT']

entities_list: @entity11054 :: ('MESH:D013134', 'Chemical') :: ['spiperone']

entities_list: @entity7690 :: ('MESH:D010869', 'Chemical') :: ['pindolol']

entities_list: @entity10896 :: ('MESH:D008719', 'Chemical') :: ['methiothepin']

entities_list: @entity9251 :: ('MESH:D018170', 'Chemical') :: ['sumatriptan']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-Hydroxytryptamine', '5-HT']

entities_list: @entity50218 :: ('MESH:C018387', 'Chemical') :: ['spiroxatrine']

entities_list: @entity6521 :: ('MESH:D008711', 'Chemical') :: ['metergoline']

answer: @entity20937 :: (487230(Tax:9615),Gene) :: ['5-HT1A']


abstract: A syndrome of severe @entity417 (Hb < or = 5 g/dl), particularly @entity417 ( @entity417 ), remains a major cause of childhood mortality in sub-Saharan Africa. We hypothesized that the @entity8193 which identifies those at the greatest risk of @entity204 often represents an @entity26 debt incurred as a result of inadequate tissue perfusion. To examine this hypothesis, we measured @entity26 consumption ( @entity4962 ) using a portable metabolic monitor. Blood @entity880 and acid-base status were also determined. Pre-transfusion data on 44 @entity1 (28 with mild symptoms, 7 with @entity649 and 9 controls) demonstrated very close dependence of @entity4962 on body surface area (BSA, R2 = 0.86, p < 0.001). After correcting for BSA, no significant differences were observed in mean @entity4962 values of the three clinical groups, indicating that a critical reduction in @entity26 delivery is not the sole explanation for the development of a @entity8193 and severe symptoms. Nine @entity1 (including five of the original 44) were monitored during transfusion. In four of the five with @entity417 , severe symptoms and severe @entity8193 , transfusion produced a marked, transient increase in @entity4962 (maximum 30-41%), with a marked fall in blood lactate and clinical improvement. These data suggest that some @entity1 with @entity417 and @entity649 accumulate an @entity26 debt when a relatively high @entity26 demand outstrips supply, this debt being repaid when supply is increased during transfusion. However, in the remaining one of these five @entity1 , an increase in @entity4962 (maximum 20%), was accompanied by a rise in blood lactate and clinical deterioration, suggesting that more pathophysiologically complex mechanisms, which may predominate in some @entity1 .

title: XXXX and @entity26 debt in African @entity1 with severe @entity417 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['severe malarial anaemia', 'anaemia', 'SMA']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity8193 :: ('MESH:D000140', 'Disease') :: ['lactic acidosis']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

answer: @entity8193 :: (MESH:D000140,Disease) :: ['Lactic acidosis']


abstract: This study was undertaken to assess the reliability of the endoscopic biopsies in the evaluation of @entity14 ( @entity14 ). In 163 consecutive @entity1 referred for surgical treatment of @entity14 , preoperative evaluation had been routinely done by colonoscopy and multiple biopsies. @entity5 were classified in 3 groups: low grade @entity5 , high grade @entity5 and @entity420 . Infiltration in depth was staged on the postoperative specimens according to the Dukes-Aster-Coller's classification. All the @entity5 were completely resected by surgery and definitive pathological diagnosis was established. An exact correlation between the pre- and postoperative staging was observed in 48% of the cases. Accuracy averaged 54% in the group-by-group comparison, with an overstaging rate of 6.7%, and an understaging rate of 39%. The incidence of @entity420 was 22% in the group with clearly benign preoperative biopsies and 50% in the other cases. There were significantly more @entity4400 @entity5 among the @entity1 referred after 3 or more endoscopic attempts (33%) than after one or two sessions (10%) (p < 0.0003). We confirm that in spite of multiple endoscopic biopsies, only a complete resection permits an exact staging and an appropriate therapeutic choice.

title: XXXX accuracy of the preoperative biopsies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'tumors']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal villous tumors', 'CRVT']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal villous tumors']


abstract: We have investigated the effects of high @entity369 ( @entity534 ) levels (7.5 mg/100 g body weight per hour) on the early integration of biocompatible mesh grafts into the @entity35 abdominal wall. Studies were performed over implantation intervals of 6, 12, 24 or 48 hours (n=12, each). @entity369 and related compounds were quantified in plasma, wound fluids and multiple tissues. Plasma @entity842 (NO) production was studied. Strips were taken from the @entity7502 fiber-host tissue interfaces (PTIs) for optical microscopic analysis and for immunohistochemical analysis using rat-specific antibodies against @entity1413 . Exogenous @entity534 was metabolized at the peripheral tissues but reliably reached the wound space. High amounts of @entity534 and @entity7222 ( @entity7222 ) were detected in the specimens considered. No changes on @entity7792 (Ctr) or NO concentrations were observed, overall suggesting that, during the period studied, the arginase pathway predominated. The acute scarring response differed significantly in the two placements considered. The P-SS interface evidenced more extensive new tissue growth than the P-DS interface. Forty-eight hours after mesh implantation cellular infiltration, fibroblast proliferation, and mesh-surrounding angiogenesis were higher in the @entity369 -treated @entity35 . Type III collagen staining was related to @entity369 treatment, being higher (++) in the study group. In conclusion, and independently of the site of mesh placement, supplemental @entity534 seemed to favorably affect early local collagen deposition. This could be potentially helpful to ameliorate the integration of biomaterials into the tissues and, consequently, to allow for the design of more selective therapeutic strategies to prevent @entity547 recurrence rates.

title: Early effects of exogenous XXXX after the implantation of prosthetic material into the @entity35 abdominal wall.

entities_list: @entity7792 :: ('CHEBI:16349', 'Chemical') :: ['citrulline']

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene']

entities_list: @entity7222 :: ('CHEBI:18257', 'Chemical') :: ['ornithine', 'Orn']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1413 :: ('MESH:D003095', 'Disease') :: ['type I and type III collagens']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine', 'Arginine']

answer: @entity369 :: (CHEBI:29016,Chemical) :: ['arginine']


abstract: OBJECTIVE: To evaluate self- and parent reports of general health status and health-related quality of life (QoL) in @entity1 and adolescents with early-onset and long-lasting type 1 @entity6 compared with the general population in Germany. RESEARCH DESIGN AND METHODS: A total of 629 subjects aged 11 to 17 years, with a type 1 @entity6 onset occurring from age 0 to 4 years during the years 1993-1999, and their parents, completed questionnaires, including the generic KINDL-R Questionnaire for Measuring Health-Related Quality of Life in @entity1 and Adolescents, revised version, to assess QoL. The comparison group (n = 6,813) was a representative sample from the German Health Interview and Examination Survey for @entity1 and Adolescents (KiGGS) study. Regression analyses were conducted using sociodemographic and health-related covariates. RESULTS: Intensified insulin therapy was used to treat 93% of @entity1 and adolescents with type 1 @entity6 . They reported "excellent" general health as often as peers (adjusted OR 0.83 [95% CI 0.66-1.04] for an "excellent" rating), but the parent-rated general health was worse than that in the general population (OR 0.60 [0.48-0.74]). The @entity1 reported increased self-esteem (adjusted difference b = 4.39 [SE 0.82]; P < 0.001) and well-being at school (b = 3.41 [0.77]; P < 0.001) but lower well-being within their families (b = -2.42 [0.80]; P = 0.002). The self- and parent-reported total QoL did not differ between the @entity1 group and the general population. The adjusted difference (SE) between the two samples in total QoL was b = 0.89 (0.52; P = 0.087) in the self-reports and b = -0.98 (0.53; P = 0.066) in the parent-reports. CONCLUSIONS: Compared with the general population, the QoL and general health status were not impaired among those aged 11-17 years with early-onset type 1 @entity6 , despite the challenges of modern therapy.

title: Health-related quality of life among German youths with early-onset and long-duration type 1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: We determined whether @entity1 marrow cells that directly form colonies in vitro could be distinguished from cells that generate or become @entity25938 only after LTMC in the presence of irradiated marrow stromal cells. In previous studies, an anti- @entity1116 antibody, L4F3, and complement (C') were used to lyse nearly all @entity25938 in marrow, and the remaining cells generated @entity25938 in LTMC. In the present studies, marrow cells were treated with L4F3 + C' and the remaining @entity1116 - cells were separated into @entity2280 + and @entity2280 - populations and placed in LTMC. Only the @entity2280 + cells were found to generate significant numbers of @entity25938 . To compare the @entity1116 - @entity2280 + and @entity1116 + @entity2280 + cells, we isolated each cell population using two-color FACS. Only LTMCs of the @entity1116 - @entity2280 + cells generated @entity25938 for greater than 5 wk. In contrast, cells that expressed both the @entity1116 and @entity2280 antigens, which contained most of the @entity25938 , generated few @entity25938 in LTMC. Fractionation of marrow cells based on right angle and forward light scattering suggested that precursors for @entity25938 have low right angle and low forward light scattering properties. The @entity1116 - @entity2280 + marrow cells were therefore further fractionated based on light scatter characteristics. Cells with low right angle and low forward light scatter formed few or no colonies on direct culture, yet generated greater numbers of @entity25938 after 4 wk of LTMC than did cells with low right angle and high forward light scatter. Most (87-98%) @entity25938 generated in the LTMCs that were initiated with @entity1116 - @entity2280 + cells were found to express the @entity1116 antigen. Thus, hematopoietic progenitors with differing proliferative and differentiative potentials can be directly separated on the basis of their expression of @entity1116 and @entity2280 cell surface antigens and their light scatter properties.

title: Precursors of colony-forming cells in XXXX can be distinguished from colony-forming cells by expression of the @entity1116 and @entity2280 antigens and light scatter properties.

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: AIM: The aim of our study was to test the feasibility of High Resolution Melting (HRM) analysis for detection of @entity817 @entity8554 mutation in various types of fine-needle aspiration (FNA) specimens from @entity1 with @entity3557 ( @entity3557 ). MATERIALS AND METHODS: We analyzed fresh thyroid aspirates and smears from eight cases of @entity3557 : three classic PTCs (CPTC), three follicular variant of PTCs (FVPTC), one tall cell, and one oncocytic variant of @entity3557 . DNA extraction was performed using a MasterPure purification kit. The isolated DNA quantity was assessed using a NanoDrop spectrophotometer and the DNA quality was tested by PCR amplification of b-globin gene and by native DNA electrophoresis. HRM was performed on a LightCycler 480 (Roche). We amplified the 15th exon of @entity817 gene, using selected primers to flank the @entity817 @entity8554 mutation point. RESULTS: For all types of cytological specimens, the quantity of isolated DNA was adequate and allowed amplification. Similarly, the DNA quality control did not show signs of DNA degradation and the DNA was amplifiable for b-globin gene. Four cases revealed the @entity817 @entity8554 mutation: two CPTCs, one oncocytic @entity3557 , one tall cell @entity3557 . None of the three cases of FVPTC had this mutation. CONCLUSIONS: HRM analysis represents a feasible and reproducible molecular technique, offering new perspectives for detecting @entity817 mutation in various FNA specimens. In our study, @entity817 @entity8554 mutation revealed a strong association with specific histological variants of @entity3557 : highly specific for CPTC, tall cell or oncocytic @entity3557 , but negative in all cases of FVPTC.

title: Detection of @entity817 XXXX mutation in thyroid fine-needle aspiration specimens by High Resolution Melting (HRM) analysis.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC']

answer: @entity8554 :: (p|SUB|V|600|E,ProteinMutation) :: ['V600E']


abstract: Between 1/85 and 1/90, 14 consecutive @entity1 were entered into a prospective study of conventional adjuvant post-operative external beam radiotherapy after complete resection for a @entity788 . The surgical procedure was a Whipple resection in nine @entity1 , a distal pancreatectomy in four @entity1 and a total pancreatectomy in one @entity1 . There were three T1b, eight T2 and three T3 @entity5 (UICC 1987); nodal involvement was present in five cases. The radiotherapy was delivered using a four-field box technique with a 23 x MV photon beam. All @entity1 received a total dose of 54 Gy to the @entity5 bed. The mean treated volume was 900 cm3. Acute @entity137 consisted mainly of @entity353 (mean: 2 kg). Two @entity1 had a grade 2 @entity294 and two @entity1 a grade 2 @entity3621 . Late effects were minimal and only observed in two @entity1 . The overall locoregional recurrence (LR) rate was 50%. The median disease-free survival was 12 months, and the median survival was 23 months. This post-operative conventional radiotherapy treatment gives results that are comparable to the results of the GITSG-adjuvant study using a combination of split-course radiotherapy and @entity1487 ( @entity1487 ).

title: Conventional external irradiation alone as adjuvant treatment in resectable XXXX : results of a prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']


abstract: Though morbidity and mortality rates following pancreatic resection have improved in recent years, they are still around 35% and 5%, respectively. Typical complications, such as @entity3472 , abscess, and subsequent @entity295 , are chiefly associated with exocrine pancreatic secretion. In order to clarify whether the perioperative inhibition of exocrine pancreatic secretion prevents complications, we assessed the efficacy of @entity2390 , a long-acting @entity1943 analogue. We conducted a randomized, double-blind, placebo-controlled, multicenter trial in 246 @entity1 undergoing major elective pancreatic surgery. @entity1 were stratified into a high-risk stratum (limited to @entity1 with @entity788 ) or low-risk stratum ( @entity1 with chronic @entity788 ). @entity1 received @entity2390 (3 x 100 micrograms) or placebo subcutaneously for 7 days perioperatively. Eleven complications were defined: death, leakage of @entity254 , @entity3472 , abscess, fluid collection, shock, @entity295 , @entity548 , @entity338 , @entity177 . Two hundred @entity1 underwent pancreatic head resection, 31 @entity1 underwent left resection, and 15 @entity1 had other procedures. The overall mortality rate within 90 days was 4.5%, with 3.2% in the @entity2390 group and 5.8% in the placebo group. The complication rate was 32% in the @entity1 receiving @entity2390 (40 of 125 @entity1 ) and 55% in @entity1 receiving placebo (67 of 121 @entity1 ) (p less than 0.005). In the @entity1 in the high-risk stratum, complications were observed in 26 of the 68 (38%) @entity1 treated with @entity2390 and in 46 of 71 (65%) @entity1 given placebo (p less than 0.01). Whereas in @entity1 in the low-risk stratum, the complication rate was 25% (14 of 57 @entity1 ) in those treated with @entity2390 and 42% (21 of 50 @entity1 ) in @entity1 given placebo (p = NS). The perioperative application of @entity2390 reduces the occurrence of @entity260 after pancreatic resection, particularly in @entity1 with @entity5 .

title: Role of XXXX in the prevention of @entity260 following pancreatic resection.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic and periampullary tumors']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['typical postoperative complications']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['pulmonary insufficiency']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency, and postoperative pancreatitis']

entities_list: @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula']

entities_list: @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide']

entities_list: @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']

answer: @entity2390 :: (MESH:D015282,Chemical) :: ['octreotide']


abstract: OBJECTIVE: The aim of this study was to identify variables associated with @entity281 events in @entity1 undergoing radical neck dissections for @entity135 . STUDY DESIGN: All hospitalizations with @entity135 that underwent radical dissection of cervical lymph nodes were selected from the Nationwide Inpatient Sample. Predictor variables included @entity1 and hospital-level factors. Outcome variable was occurrence of >= 1 never events. Association between predictor and outcome variables was examined by using bivariate and multivariable logistic regression models. RESULTS: There were 10,660 hospitalizations. At least 1 never event occurred in 7.8% of hospitalizations. Teaching hospitals were associated with higher odds of having >= 1 never event compared with nonteaching hospitals (odds ratio 1.92; P = .02). Presence of comorbid conditions and race were other significant predictors of never events. CONCLUSIONS: Teaching hospitals and presence of comorbid conditions were associated with higher odds of experiencing a never event.

title: Predictors of never events in XXXX undergoing radical dissection of cervical lymph nodes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection-related never']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Between July 1, 1990 and July 31, 1992, altogether 81 female @entity1 were operated on endoscopic surgery, diagnosis was: @entity5 . Of the overall number of @entity1 with the same diagnosis, which @entity5856 up to 110, those 81 made up roughly 75 per cent. If the @entity1 was under 45 years old, the organ was saved, if the @entity1 was more than 45 years old, an adnexectomy was carried out. For the time being @entity1 are chosen for an endoscopic operation on the basis of the results of a preoperational vaginal ultrasound examination. In the beginning one @entity1 showed a @entity5 of the borderline type in the pathologic anatomy examination. With all other @entity1 the histology showed that the original statement of a @entity5 was right. There was no age limit. The youngest @entity1 was 16 years old, the oldest 82 years old. Both @entity1 were diagnosed the same plain @entity42 . Furthermore, the size of the @entity5 did not primarily keep us from applying the endoscopic operational treatment. A preoperative determination of the tumourmarker 12-5 does not seem to be useful. There was no case of a premalign or malign process going along with a preoperative increase.

title: [Diagnosis and endoscopic therapy of XXXX ].

entities_list: @entity42 :: ('MESH:D010048', 'Disease') :: ['ovarian cyst']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cystic tumour', 'cystic adnex tumour', 'benign tumour']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cystic adnexa tumors']


abstract: STUDY OBJECTIVE: To compare the efficacy of @entity1875 , methohexital, and midazalom in providing adequate sedation during administration of retrobulbar block and satisfactory postoperative @entity2730 . DESIGN: Retrospective chart review over a 4-month period. SETTING: Ambulatory @entity1 in the main operating room of a university-affiliated hospital. @entity1 : One hundred forty-seven ambulatory @entity1 undergoing ophthalmologic surgery of less than 2 hours' duration under regional anesthesia consisting of retrobulbar or peribulbar block and intravenous (IV) sedation. INTERVENTIONS: One of three drugs-- @entity1875 0.47 +/- 0.06 mg/kg, @entity1363 0.02 +/- 0.005 mg/kg, or methohexital 0.45 +/- 0.16 mg/kg--was administered IV. @entity1 were observed for a minimum of 60 seconds or until adequate sedation was achieved, after which a retrobulbar or peribulbar block was performed. MEASUREMENTS AND MAIN RESULTS: Blood pressure, electrocardiogram, and @entity26 saturation were monitored and recorded. @entity1 were observed for @entity386 , @entity11637 , @entity158 on injection, excitement, @entity400 , grimacing, or verbal response during the block. The requirement for additional sedation intraoperatively was noted. @entity1 were questioned postoperatively in the ambulatory recovery room for recall of needle insertion or discomfort during the block, as well as about their satisfaction with the overall experience. CONCLUSIONS: Grimacing or verbal response during the retrobulbar or peribulbar block did not predict or correlate with @entity1 recall. @entity1875 was equal to both @entity1363 and methohexital in providing adequate sedation and postoperative @entity2730 but possesses the added advantages of @entity1209 , lower intraocular pressure, and earlier return-to-home readiness.

title: A comparison of XXXX , @entity1363 , and methohexital for sedation during retrobulbar and peribulbar block.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['reduced postoperative vomiting']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol', 'Propofol']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['propofol']


abstract: PURPOSE: To determine the incidence of @entity6 ( @entity6 ) progression after phacoemulsification in @entity1 with @entity2175 . SETTING: Service of Ophthalmology, University of Sant Joan, Barcelona, Spain. METHODS: This prospective study evaluated 132 @entity1 with @entity6 who had monocular phacoemulsification. A control group comprised the @entity1 ' @entity735 . Data analysis included preoperative retinal findings and @entity6 status; hemoglobin A1c (HbA1c), low-density lipoprotein @entity165 , and @entity1674 levels; insulin treatment; and arterial @entity101 . RESULTS: Postoperative visual acuity increased by 2 or more lines in 105 @entity1 (79.55%); the mean postoperative acuity was 0.63 +/- 0.28 ( @entity168 ). @entity6 in the operated eye progressed in 31 @entity1 (23.48%) and in the fellow eye in 28 @entity1 (21.21%). The progression was associated with high levels of HbA1c and @entity6 duration in both groups. @entity1103 occurred in the operated eye in 8 @entity1 (6.06%) and in the fellow eye in 6 @entity1 (4.54%). Pseudophakic macular @entity4 developed in 2 eyes (1.52%). The progression of @entity1103 was not associated with the risk factors studied. CONCLUSION: Uneventful phacoemulsification @entity231 surgery may not cause @entity6 progression.

title: XXXX and macular @entity4 progression after phacoemulsification: prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['type II diabetes']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['DR', 'diabetes mellitus', 'Diabetic retinopathy', 'diabetic retinopathy']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['Diabetic macular edema', 'diabetic macular edema']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['contralateral eyes']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Nonproliferative diabetic retinopathy']


abstract: UNASSIGNED: Alternative graft sources, [umbilical cord blood (UCB), matched unrelated donors (MUD), or @entity5527 ( @entity5527 )] enable @entity1 without a matched sibling donor to receive potentially curative hematopoietic cell transplantation (HCT). Retrospective studies demonstrate comparable outcomes among different graft sources. However, the risk and types of @entity281 have not been compared among graft sources. Such information may influence the choice of a particular graft source. We compared the incidence of @entity364 in 1,781 adults with @entity3052 who received alternative donor HCT (UCB = 568, MUD = 930, @entity5527 = 283) between 2008 and 2011. The incidence of @entity2348 at one year was 72%, 59%, and 65% (p<0.0001) for UCB, MUD and @entity5527 , respectively. Incidence of @entity1800 at one year was 68%, 45%, 53% (p<0.0001) for UCB, MUD, and @entity5527 respectively. In multivariable analysis, @entity364 were more common after either UCB or @entity5527 than MUD, (p<0.0001). Bacterial and viral, but not fungal, @entity281 were more common after UCB than @entity5527 (p=0.0009 and <0.0001, respectively). The presence of @entity1800 was not associated with an increased mortality. Overall survival (OS) was comparable among UCB and @entity5527 @entity1 with Karnofsky performance status (KPS) >= 90%, but was inferior for UCB for @entity1 with KPS < 90%. @entity2348 were associated with poorer OS. Future strategies focusing on infection prevention and treatment are indicated to improve HCT outcomes.

title: Infection Rates among @entity3052 XXXX Receiving Alternative Donor Hematopoietic Cell Transplantation.

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['Bacterial and fungal infections', 'bacterial infection']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['bacterial, viral, and fungal infections', 'bacterial, fungal, and viral infections']

entities_list: @entity5527 :: ('MESH:C536928', 'Disease') :: ['MMUD', 'mismatched unrelated donors']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: We report a case of recurrent @entity356 that was effectively controlled with radiation therapy. A 63-year-old @entity1 underwent total gastrectomy, cholecystectomy and D2 dissection in February 2006 for early @entity356 in the upper third area that was diagnosed with @entity4937 and Stage IA (T1 (SM), N0, H0, P0, CY0, M0). He underwent lateral segmentectomy of the liver for liver @entity3 of S2/3. He suffered from No. 12 lymph node(LN) @entity3 in February 2009, so @entity2600 , next to S-1, was administered. @entity715 ( @entity715 ) and liver S8 @entity3 were observed in September 2009. First, chemoradiotherapy (CRT) ( S-1 80 mg/body+total of 65 Gy per 26 Fr) for #12 LN and @entity715 was performed and, in turn, stereotactic radiation therapy (SRT: total of 52.8 Gy per 4 Fr) was performed. A complete response in all of @entity5 was noted and he was presently alive with no sign of recurrence after 19 months after CRT and SRT. Grade 3 or 4 adverse events were not recognized. It is thought that radiation therapy is one of effective treatments for localized @entity3 from @entity356 .

title: [A case of recurrent XXXX successfully treated with radiation therapy].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity4937 :: ('MESH:D000231', 'Disease') :: ['papillary adenocarcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['Portal tumor thrombosis', 'PTT']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: @entity1760 ( @entity4612 ) plays an important role in the prevention and treatment of central nervous system (CNS) damage. This pathology is a serious problem in @entity1 undergoing coronary artery bypass graft surgery (CABG) with extracorporeal circulation (ECC). Its biochemical diagnosis is mainly based on @entity4483 protein observations. This study aims to analyse different forms of @entity4612 supplementation on serum @entity4483 concentrations in @entity1 who have undergone CABG. @entity1 AND METHODS: One hundred and twenty adult @entity1 , who underwent CABG with extracorporeal circulation (ECC) with normovolemic haemodilution (NH) under general anaesthesia, were examined. According to the dose of @entity4612 supplementation, @entity1 were divided into six groups: A) @entity1 receiving 3.33 @entity4612 of @entity2400 per min intravenously (i.v.), during surgery and the early postoperative period (18 hours); B) @entity1 receiving oral @entity4612 supplementation (OPS- @entity4612 ) and 3.33 @entity4612 of @entity2400 per min i.v., preoperatively; C) @entity1 receiving 6.66 @entity4612 of @entity2400 per min i.v.; D) @entity1 receiving OPS- @entity4612 and 6.66 @entity4612 of @entity2400 per min i.v.; E) @entity1 receiving 10 @entity4612 of @entity2400 per min i.v.; F) @entity1 receiving OPS- @entity4612 and 10 @entity4612 of @entity2400 per min i.v. Additionally, all @entity1 were divided into three groups: O) @entity1 , who did not receive @entity935 or @entity452 infusion, DOP) those receiving @entity935 infusion, and DOB) those receiving @entity452 infusion in doses dependent on their clinical state. Total serum @entity4612 concentrations ( @entity4612 (t)) were measured at five time-points: 1) just before anaesthesia; 2) 10 min after ECC; 3) just after surgery, 4) in the morning of the first postoperative day, 5) in the morning of the second postoperative day. RESULTS: ECC resulted in @entity4483 elevation in all @entity1 . In groups A, B and C, @entity4483 increased from the second to the fourth time-points; in groups D and F, @entity4483 increased at the second and third time-points; and in group E, @entity4483 increased only at the third time-point. The highest serum @entity4483 concentrations were noted in groups A and B, and the lowest concentrations were noted in groups E and F. There were significant correlations between serum @entity4483 and @entity4612 (t) concentrations at time-point 3 in groups A, B, C and F. Moreover, there were significant overall correlations between @entity4483 and @entity4612 in groups A and B. CONCLUSIONS: 1) ECC resulted in @entity4483 elevation, 2) infusion of 10 @entity4612 of @entity2400 per min reduced serum @entity4483 concentrations, and 3) @entity935 infusion resulted in the highest serum @entity4483 concentrations.

title: @entity1760 supplementation significantly reduces serum @entity4483 concentrations in XXXX who have undergone coronary artery bypass surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['Magnesium']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: We describe a @entity3969 with focal @entity4575 and a complex, @entity5 specific chromosome 11 aberration: a homozygous deletion of the entire @entity8587 gene within a heterozygous 11p13 deletion and an additional region of @entity8882 ( @entity8882 ) limited to 11p15.5-p15.2 including the @entity5100 gene. The @entity5 carried a heterozygous @entity48212 mutation in @entity3546 . Cells established from the @entity5 carried the same chromosome 11 aberration, but a different, homozygous p.S45   @entity3546 mutation. @entity8882 ( @entity8882 ) 3p21.3pter lead to the homozygous @entity3546 mutation. The @entity5 cell line was immortalized using the catalytic subunit of @entity1 telomerase ( @entity2215 ) in conjunction with a novel thermolabile mutant (U19dl89-97tsA58) of SV40 large T antigen (LT). This cell line is cytogenetically stable and can be grown indefinitely representing a valuable tool to study the effect of a complete lack of @entity8587 in @entity5 cells. The origin/fate of @entity3969 with @entity8587 mutations is currently poorly defined. Here we studied the expression of several genes expressed in early kidney development, e.g. @entity48213 , @entity22284 , @entity7953 , @entity48214 , @entity48215 and @entity23503 and show that these are expressed at similar levels in the parental and the immortalized Wilms10 cells. In addition the limited potential for muscle/ osteogenic/ adipogenic differentiation similar to all other @entity8587 mutant cell lines is also observed in the @entity5 cell line and this is retained in the immortalized cells. In summary these Wilms10 cells are a valuable model system for functional studies of @entity8587 mutant cells.

title: Establishment of a Conditionally Immortalized @entity3969 Cell Line with a Homozygous @entity8587 Deletion within a Heterozygous 11p13 Deletion and XXXX Limited to 11p15.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Wilms10 tumor']

entities_list: @entity4575 :: ('MESH:D000708', 'Disease') :: ['anaplasia']

entities_list: @entity48212 :: ('p|SUB|T|41|A', 'ProteinMutation') :: ['p.T41A']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumors', 'stromal predominant Wilms tumor']

entities_list: @entity8882 :: ('MESH:D024182', 'Disease') :: ['UPD', 'Uniparental disomy', 'uniparental disomy']

answer: @entity8882 :: (MESH:D024182,Disease) :: ['UPD']


abstract: BACKGROUND: There are few studies which analyse the characteristics of @entity1576 according to profiles of sensitisation to different allergens. This study describes the clinical features and therapeutic approaches, according to the sensitisation profile to relevant aeroallergens, in a sample of adult @entity1 with a first-time diagnosis of @entity1576 ( @entity2490 and/or @entity565 ). METHODS: 1287 @entity1 , enrolled consecutively in the spring of 2010 by 200 @entity566 specialists, were classified into four groups according to sensitisation to significant allergens in each geographical area (grass pollen, olive pollen, grass and olive pollen, house dust mites). Information was obtained on demographics, diagnostic procedures used, treatments prescribed, clinical characteristics of the @entity2490 , and severity and control of @entity565 . RESULTS: Of the @entity1 , 58.6% had @entity2490 only and 38.7% had both @entity2490 and @entity565 . @entity1 with more severe @entity2490 had more severe and poorer controlled @entity565 . Sensitisation to different allergens was not associated with significant differences in severity and control of @entity565 , but @entity1 with house dust mite @entity566 presented persistent @entity2490 more frequently. Allergy to grass pollen was significantly associated with @entity5419 . Differences were observed in the frequency of prescription of immunotherapy and antileukotrienes in @entity1 allergic to house dust mites and of topical corticosteroids in @entity1 with @entity2023 . CONCLUSIONS: It was observed in this study that in @entity1576 , there are clinical differences as well as differences in diagnostic procedure and therapeutic attitudes, depending on the clinically relevant allergen.

title: Diagnostic and therapeutic approaches in XXXX are different depending on the profile of aeroallergen sensitisation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['pollen allergy']

entities_list: @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergies']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory allergy disease', 'respiratory allergy', 'allergic respiratory disease']

answer: @entity1576 :: (MESH:D012131,Disease) :: ['respiratory allergy']


abstract: OBJECTIVES: To seek regional differences within the USA in the 'all-cause mortality' of @entity101 @entity1 during the 14 years following institution of antihypertensive treatment, and to determine how other pretreatment data can be related to that all-cause mortality. DESIGN: In the mid-1970s pretreatment clinical data were collected and computerized for 5698 @entity101 veterans. Deaths during the subsequent 14 years were obtained from the Veterans Administration Beneficiary Identification and Record Location System and the National Death Index. Relationships between pretreatment data and @entity204 were sought using chi 2- and z-tests for bivariate comparisons and logistic regression for multivariate analyses. @entity1 : Half of the 5698 previously untreated male @entity101 military veterans were Black. Their mean age was 52.3 years and mean pretreatment blood pressure was 160/104 mmHg. Additional pretreatment data included body mass index, cigarette and @entity167 usage, age and self-reported comorbidities. These patients began antihypertensive treatment during 1974-1975 in 28 special Veterans Administration outpatient clinics throughout the USA. RESULTS: During the 14 years after treatment began, 2283 of these @entity1 (40%) died. Those from the southeastern USA, i.e. in the ' @entity64 Belt', were 1.32-fold more likely to die than @entity1 living elsewhere. Other pretreatment characteristics positively related to all-cause mortality included age, systolic blood pressure, cigarette and @entity167 usage, and self-reported comorbidities. Race was unrelated to mortality. CONCLUSION: All-cause mortality was increased among @entity101 subjects from the southeastern USA. The reasons for this excess mortality remain unclear. Other pretreatment characteristics were also related to mortality, but race was not.

title: Effects of ' @entity64 -belt' residence, screening blood pressure and personal history risk factors on all-cause mortality among XXXX veterans.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: Benign recurrent @entity9744 ( @entity9745 or @entity11762 ) is a rare autosomal recessive form of @entity409 , which usually becomes manifest in childhood. Characteristic are recurrent episodes of @entity1087 and itching of different duration. Number and duration of @entity2749 attack and asymptomatic period develop individually. For diagnosis of @entity9745 following criteria are proposed: At least three episodes of severe @entity1087 and @entity111 with biochemical evidence of @entity1448 , normal intra-and extrahepatic bile ducts on cholangiography, absence of a factor known to produce @entity9744 and symptom-free intervals of several months or years. Often the diagnosis of @entity9745 is made very late and @entity1 have to suffer invasive investigations (explorative laparotomy). Because of the unknown pathophysiological mechanism there is no specific treatment. We report on a 53-year-old @entity1 with @entity1087 , severe @entity111 , @entity391 , loss of hair and weight, extreme @entity22 and intractable cough. At the onset of the attack an increase of serum @entity648 concentration and serum alkaline phosphatase was observed, whereas @entity492 and @entity493 aminotransferase and gamma-glutamyltransferase were normal. Histological findings of liver biopsy revealed accumulation of bile plugs in bile canaliculi. The long-term follow-up of our @entity1 confirms that the prognosis is good.

title: [Follow-up of benign recurrent XXXX ( @entity11762 ) over 46 years].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']

entities_list: @entity11762 :: ('MESH:C535933', 'Disease') :: ['Summerskill-Walshe-Tygstrup-syndrome']

entities_list: @entity9744 :: ('MESH:D002780', 'Disease') :: ['intrahepatic cholestasis']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['sleeplessness']

answer: @entity9744 :: (MESH:D002780,Disease) :: ['intrahepatic cholestasis']


abstract: AIM: This study involved a large nationwide Danish cohort to evaluate the hypothesis that a high lymph node harvest has a positive effect on survival in curative resected @entity5 and a low lymph node ratio has a positive effect on survival in @entity5 . METHOD: Analysis of overall survival was conducted using a nationwide Danish cohort of @entity1 treated with curative resection of @entity5 . All 8901 @entity1 in Denmark diagnosed with @entity694 and treated with curative resection in the period 2003-2008 were identified from the Danish @entity14 Group (DCCG). The impact of lymph node count and lymph node ratio was analysed. RESULTS: Overall 5-year survival was 56.8 and 66.6%, (P  <  0.0001) for lymph node counts of fewer than 12 and 12 or more, respectively. The percentages of lymph node positive @entity1 in the two groups were 29.8 and 40.3% (P  <  0.0001), respectively. When putting the Stage III @entity1 into four subgroups according to the lymph node ratio (cut-off points 1/12, 1/4 and 1/2) we found an overall 5-year survival rate of 68.1, 57.2, 49.3 and 32.4% (P  <  0.0001). Lymph node count and lymph node ratio were independent prognostic factors in multivariate analysis. CONCLUSION: High lymph node count was associated with improved overall survival in @entity694 . Lymph node ratio was superior to N-stage in differentiating overall survival in @entity5 . Stage migration was observed.

title: The relation between lymph node status and survival in XXXX : results from a prospective nationwide cohort study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Stage III colon cancer', 'Stage I-III colon cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['adenocarcinoma of the colon', 'colon cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Stage I-III colon cancer']


abstract: The objective of this study was to determine the susceptible days for the adverse effects of @entity15523 ( @entity11559 ) on development of reproductive system in male offspring following maternal administration on successive 3-day period during late pregnancy. Pregnant @entity35 were given @entity11559 by gastric intubation at 1000 or 1500 mg/kg on days 12-14 or 18-20 of pregnancy or at 500, 1000 or 1500 mg/kg on days 15-17 of pregnancy. A significant decrease in the maternal body @entity1017 and/or food consumption was found in the @entity11559 -treated groups regardless of the days on which @entity11559 at 1000 and 1500 mg/kg was given. A significant increase in the number of resorptions per litter was found in the groups given @entity11559 at 1500 mg/kg on days 12-14 and 15-17 of pregnancy. The weights of male and female fetuses were significantly decreased in the groups given @entity11559 at 1000 and 1500 mg/kg on days 12-14 and 18-20 and at 1500 mg/kg on days 15-17. A significant increase in the incidence of fetuses with undescended testes was found at 1500 mg/kg on days 12-14 and at all doses on days 15-17. A significant @entity393 (AGD) of male fetuses was observed in the groups treated with @entity11559 regardless of the days of treatment. The AGD/body weight ratio in male fetuses was significantly reduced in the groups given @entity11559 on days 15-17, but neither on days 12-14 nor 18-20. The AGD of female fetuses in the @entity11559 -treated groups was comparable to that in the control group. It was concluded that period of days 15-17 of pregnancy was the most susceptible for @entity11559 -induced undescended testes and decreased AGD in male offspring.

title: Critical period for adverse effects on development of reproductive system in male offspring of XXXX given @entity15523 during late pregnancy.

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['decrease in the anogenital distance']

entities_list: @entity15523 :: ('MESH:D003993', 'Chemical') :: ['di-n-butyl phthalate']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Dynamic SPECT was performed using 201TICI in a total of 21 @entity11 , 14 cases of @entity463 ( @entity463 ) and 7 cases of @entity816 ( @entity816 ), to investigate the relationship between test results and @entity5 . The accumulation of isotope (counts/pixel) in the @entity5 was measured every 3 minutes with dynamic SPECT. The initial 3-minute value was reduced from subsequent accumulations (counts/minute) to obtain the time-activity curve (TAC). Thallium index (TL index), the ratio of 15-minute accumulation in the @entity5 to that in the same region of the contralateral normal brain, was also calculated. TL index was significantly higher (p < 0.05, Mann-Whitney test) in @entity463 (6.25 +/- 1.97) than in @entity816 (4.10 +/- 1.66), although no clear differential value could be determined between the two. @entity11636 in the @entity463 group showed that compared with the initial 3-minute value, accumulation increased significantly (p < 0.05) at every measurement point after isotope injection: 6 minutes, 0.660 +/- 0.671; 9 minutes, 1.322 +/- 1.319; 12 minutes, 1.315 +/- 1.632 and 15 minutes, 1.234 +/- 1.552. The increase in isotope accumulation in the @entity5 after 6 minutes or later was noted in 11 of the 14 cases in the @entity463 group. In the @entity816 group, however, there were no significant differences between the initial 3-minute value and value after 6 minutes (-0.283 +/- 0.462), 9 minutes (-0.574 +/- 0.681), 12 minutes (-0.690 +/- 0.611) and 15 minutes (-0.707 +/- 0.636) after isotope injection. A decrease in isotope accumulation in the @entity5 after 6 minutes or later was noted in 6 of the 7 cases in the @entity816 group. Compared with static SPECT, dynamic SPECT, which can be performed easily and quickly, is more useful in clinical settings because of its high ability to differentiate the grade of @entity11 .

title: [201T1C1 accumulation dynamics in XXXX with different grades of @entity5 : an investigation using dynamic SPECT].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['malignancy of gliomas', 'gliomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytoma', 'AA']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GM']

answer: @entity11 :: (MESH:D005910,Disease) :: ['glioma']


abstract: OBJECTIVE: Our purpose was to determine the association of @entity5752 ( @entity5752 ) and soluble @entity5750 (sCD14) with the proinflammatory response among @entity1 in @entity3152 . The binding of lipopolysaccharide (LPS) with @entity5752 and sCD14 activates macrophages at LPS concentrations up to 1000 times lower than required with LPS alone. @entity5752 and sCD14 in amniotic fluid could explain the high concentrations of cytokines present in the amniotic fluid of culture-positive @entity1 and the presence of cytokines in the amniotic fluid of culture-negative @entity1 . STUDY DESIGN: A cohort of 169 afebrile @entity1 in @entity3152 with intact membranes had amniotic fluid collected by transabdominal amniocentesis for culture and for @entity5752 , sCD14, and @entity650 ( @entity650 ) determinations by enzyme-linked immunosorbent assay. @entity650 levels of >2 ng/mL were considered elevated. Statistical analyses included analysis of variance, multiple comparisons with Bonferroni correction, and linear regression. RESULTS: All 169 amniotic fluid samples had measurable @entity5752 and sCD14. Subjects were categorized by amniotic fluid culture results and @entity650 concentration into 3 groups: (1) positive amniotic fluid culture, (2) negative amniotic fluid culture, elevated @entity650 concentration, and (3) negative amniotic fluid culture, low @entity650 level. Geometric mean @entity5752 and sCD14 levels differed significantly among groups such that levels were approximately twice as high among pregnancies with positive amniotic fluid culture or elevated @entity650 compared with those without evidence of @entity32 (both P <.001). sCD14 was inversely associated with enrollment gestational age independent of amniotic fluid culture results and @entity650 concentrations. Among culture negative, low @entity650 pregnancies, sCD14 decreased 3.5% for each additional week of gestation (95% confidence interval [CI], 0.01%-6.4%; P =.02). @entity5752 levels showed a similar trend in this group (P =.09). One hundred eleven subjects had detectable @entity650 levels. Among these subjects, @entity650 increased by 2.1-fold for every 10-fold increase in @entity5752 (95% CI, 1.1-4.0; P =.02) and by 28.4-fold for every 10-fold increase in sCD14 (95% CI, 10.4-77.4; P <.001) with adjustment for gestational age by linear regression. CONCLUSIONS: @entity5752 and sCD14 are present in amniotic fluid of preterm pregnancies and are linearly associated with amniotic fluid @entity650 concentrations. These molecules may amplify the cytokine response and thereby help explain the presence of cytokines in amniotic fluid when culturable quantities of microbes are absent.

title: Amniotic fluid XXXX and soluble @entity5750 as mediators of the inflammatory response in @entity3152 .

entities_list: @entity5752 :: ('3929', 'Gene') :: ['lipopolysaccharide-binding protein', 'LBP']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labor']

answer: @entity5752 :: (3929,Gene) :: ['lipopolysaccharide-binding protein']


abstract: The effect of @entity619 on interstitial @entity101 was evaluated in a @entity1 @entity694 . Two weeks after transplantation of the @entity5 line LS174T into @entity915 @entity19 , recipients with @entity5 > 8.5 mm in diameter received one daily injection i.p. on days 1-4, at five different doses in the range of 0.3-30 mg/kg. Controls received saline. The interstitial fluid pressure (IFP) was determined in all @entity5 pretherapeutically on days 1, 4, and 7. A total of 68 @entity5 were examined, and in an additional group of 22 @entity19 , the effect of 4-day @entity619 therapy on blood pressure was evaluated. In the 3-, 10-, and 30-mg/kg dose groups a significant reduction in IFP was found, comparing treated versus controls and individual measurements from day 1 versus day 4. No effects were observed on day 7. A marginal effect was observed after 1.0 mg/kg, whereas 0.3 mg/kg did not affect the IFP. The systemic blood pressure was slightly increased by the @entity619 therapy, and no treatment related changes in @entity5 sizes were observed. Our findings indicate that the reversible decrease in @entity5 IFP by @entity619 is an effect of a reduced microvascular permeability and vascular hydraulic conductivity in the @entity5 .

title: @entity619 reduces the interstitial fluid pressure in a @entity1 XXXX xenograft.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic adenocarcinoma']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon adenocarcinoma']


abstract: Loma salmonae is a common gill parasite of salmonids, and essentially all species in the genus @entity11806 are susceptible. Infections occur in both fresh and salt water. Loma salmonae is directly transmissible by ingestion of spores or infected tissue. The parasite infects the wall of blood vessels of various organs, but the gill is the primary site of @entity281 . Initial @entity281 occurs in the intestine, and xenomas are easily detected in the gills by standard histology at 4-6 wk post-exposure. A few presporogonic stages of the parasite are found in the heart endothelium prior to xenoma formation in the gills. Ultrastructure studies of early infections demonstrated that wandering blood cells transport the meronts to the gills, and that merogony occurs in pillar cells and other cells underlying the gill endothelium. Xenomas develop in these cells, resulting in hypertrophied host cells filled with spores. Xenomas @entity397 , and are associated with severe @entity32 in which free spores are found in macrophages. The parasites are most pathogenic during this phase of the @entity281 , resulting in severe @entity1333 and clinical disease. Both @entity5660 ( @entity5660 ) and @entity11806 ( @entity11806 ishawytscha) recover from infections, but free spores persist in kidney and spleen phagocytes for many months after xenomas are absent in @entity11806 . Fish that have recovered from the @entity281 show strong immunity against the parasite, lasting up to 1 year. Fish are susceptible to @entity281 by other routes of exposure by spores; co-habitation, anal gavage, and intramuscular, intraperitoneal and intravascular injection. Autoinfection probably occurs following release of spores in blood vessels after @entity397 . The optimal temperature for L. salmonae infections is 15-17 degrees C, with a permissive range of 11-20 degrees C.

title: Review of the sequential development of Loma salmonae (Microsporidia) based on experimental infections of XXXX ( @entity5660 ) and @entity11806 ( @entity11806 ).

entities_list: @entity5660 :: ('8022', 'Species') :: ['Oncorhynchus mykiss', 'rainbow trout']

entities_list: @entity11806 :: ('74940', 'Species') :: ['Chinook salmon', 'Oncorhynchus']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['xenomas rupture', 'ultimately rupture']

answer: @entity5660 :: (8022,Species) :: ['rainbow trout']