abstract: UNASSIGNED: 10550 Background: Next generation sequencing has revolutionized the study of @entity5 biology by providing an unprecedented view of @entity5 genomes. However, high throughput sequencing has conventionally utilized fresh frozen tissue collected for research prospectively. The ability to apply this tool to @entity406 -fixed, @entity982 -embedded (FFPE) clinical specimens, where nucleic acid integrity is not optimal and where next generation sequencing has been challenging, would enable its use to improve @entity1 care and clinical research. METHODS: Total RNA was extracted from FFPE blocks of 7 lung @entity420 and matching normal lung tissue for 6 of the 7 @entity5 . Genotype information for selected mutation alleles in @entity470 , @entity876 , etc. was previously determined using the SNaPshot single nucleotide polymorphism genotyping platform. Ribosomal RNA was depleted using biotinylated oligos targeting 28S and 18S ribosomal subunits. cDNA was synthesized using random hexamers. Whole transcriptome sequencing was performed using the Helicos BioSciences Heliscope single molecule sequencer. Sequences were aligned to reference @entity1 transcriptome and genome as well as a reference of mutation alleles. RESULTS: Ribosomal RNA depletion increased mRNA yield from ~20% to ~35% of RNA species sequenced. We obtained ~10 million aligned mRNA reads per sample. We re-identified clinically relevant @entity470 exon 19 deletions in two samples. In another sample, we discovered an exon 20 insertion in @entity470 that was not previously appreciated. In a fourth sample, we were able to detect the presence of an @entity16242 - @entity7041 fusion through the integration of sequence and expression information. CONCLUSIONS: This study shows that RNA sequencing from FFPE @entity1 samples is feasible, and in cases where gene expression is sufficient, enables the determination of clinically relevant mutations. These findings represent the initial step towards leveraging the power of next generation sequencing into a comprehensive diagnostic and clinical research tool.

title: Single molecule RNA sequencing of XXXX -fixed paraffin-embedded tissue derived from @entity1 with lung cancer.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity406 :: (MESH:D005557,Chemical) :: ['formalin']


abstract: BACKGROUND: Existing studies of @entity384 deal mainly with early survival. This population-based study examines long-term outcomes for @entity1 with @entity384 . METHODS AND RESULTS: The diagnosis of @entity384 was based on clinical, echocardiographic, and pathological findings. The primary study end point included time to the combined outcome of @entity204 or cardiac transplantation. There were 175 @entity1 0 to <10 years of age at the time of diagnosis. Survival free from @entity204 or transplantation was 74% (95% confidence interval, 67-80) 1 year after diagnosis, 62% (95% confidence interval, 55-69) at 10 years, and 56% (95% confidence interval, 46-65) at 20 years. In multivariable analysis, age at diagnosis <4 weeks or >5 years, @entity296 , and lower baseline left ventricular fractional shortening Z score were associated with increased risk of @entity204 or transplantation, as was lower left ventricular fractional shortening Z score during follow-up. At 15 years after diagnosis, echocardiographic normalization had occurred in 69% of surviving study subjects. Normalization was related to higher baseline left ventricular fractional shortening Z score, higher left ventricular fractional shortening Z score during follow-up, and greater improvement in left ventricular fractional shortening Z score. @entity1 with @entity2401 had better survival and a higher rate of echocardiographic normalization. At the latest follow-up, 100 of 104 of survivors (96%) were free of @entity299 , and 83 (80%) were no longer receiving pharmacotherapy. CONCLUSIONS: @entity204 or transplantation occurred in 26% of @entity1 with @entity384 within 1 year of diagnosis and ~1% per year thereafter. Risk factors for @entity204 or transplantation include age at diagnosis, @entity296 , and severity of @entity1002 . The majority of surviving subjects are well and free of cardiac medication.

title: Long-term outcomes of @entity384 diagnosed during childhood: results from a national population-based study of childhood XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['familial cardiomyopathy']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['childhood dilated cardiomyopathy', 'dilated cardiomyopathy']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac symptoms']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['lymphocytic myocarditis']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']

answer: @entity296 :: (MESH:D009202,Disease) :: ['cardiomyopathy']


abstract: UNASSIGNED: Despite decades of epidemiological investigation, little is known about the etiology of the central nervous system (CNS) @entity5 , and few well-established risk factors have been recognized. This study tested the presence of @entity6059 (MCPyV), the only member of the Polyomaviridae family convincingly linked to @entity1 @entity5 , in diverse CNS @entity5 . In total, 58 @entity1221 biopsies were analyzed for the MCPyV large T-antigen (LT-Ag) gene by quantitative real-time PCR. @entity6059 LT-Ag DNA load was determined as viral copies per cell and viral copies per microliter of purified genomic DNA from @entity1221 samples. The MCPyV LT-Ag sequence was detected in 34 (58.6%) of the 58 tested samples. Viral LT-Ag was quantified in 19.0% of @entity808 , 13.8% of @entity1653 , and 5.2% of @entity977 . The difference between MCPyV positivity in different types of CNS @entity5 was not statistically significant (P   =   0.066). The mean LT-Ag copy number in 34 positive samples was 744.5        737.7 and 0.056   *   10(-3)         0.091   *   10(-3) per microliter and per cell, respectively. Among @entity1221 , the mean MCPyV copy number was higher in @entity1653 (993.8        853.2 copy per microliter and 0.098   *   10(-3)         0.108   *   10(-3) copy per cell). Multiple linear regression analysis revealed statistically significant difference in MCPyV copy number between @entity1653 and other @entity1221 types, when the model was adjusted for age and sex (P   =   0.024). This study shows the first evidence of the detection of MCPyV LT-Ag sequence at a low copy number in @entity1 CNS @entity5 . J. Med. Virol.    2015 Wiley Periodicals, Inc.

title: Detection of @entity6059 large T-antigen sequences in @entity1 XXXX .

entities_list: @entity808 :: ('MESH:D009442', 'Disease') :: ['schwannomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'cancer', 'malignancies']

entities_list: @entity1221 :: ('MESH:D016543', 'Disease') :: ['CNS tumor', 'MCPyV-positive CNS tumors']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma', 'meningiomas']

entities_list: @entity6059 :: ('493803', 'Species') :: ['Merkel cell polyomavirus']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas']

answer: @entity1221 :: (MESH:D016543,Disease) :: ['central nervous system tumors']


abstract: BACKGROUND: The necessity of surgical treatment of liver metastases of @entity356 is still controversial. @entity1 AND METHODS: We conducted a multicenter retrospective cohort study of liver-limited @entity3 of @entity356 treated surgically between 2000 and 2010. In this study, 103 @entity1 were registered, with nine @entity1 excluded from the analysis as they did not meet the eligibility criteria. RESULTS: Of the 94 @entity1 , 69 underwent surgical resection, 11 underwent surgical resection combined with radiofrequency ablation or microwave coagulation therapy for small or deep @entity5 , and 14 underwent radiofrequency ablation or microwave coagulation therapy only. Synchronous and metachronous metastases were found in 37 and 57 @entity1 , respectively. The 3- and 5-year overall survival rates of all the @entity1 were 51.4 and 42.3  %, respectively. The 3- and 5-year relapse-free survival rates were 29.2 and 27.7  %, respectively. No significant difference in prognosis was observed between the @entity1 who underwent surgical resection and those who underwent ablation therapy. The @entity1 with @entity99 and low-grade lymph node metastases of primary @entity356 had significantly better overall survival and relapse-free survival. CONCLUSIONS: To our knowledge, this study is the largest series and first multicenter cohort study of liver-limited @entity3 of @entity356 . The study indicated that @entity1 with a single liver @entity3 with a grade lower than N2 lymph node @entity3 of the @entity75 are the best candidates for liver resection.

title: Surgical treatment of liver XXXX of @entity356 : a retrospective multicenter cohort study (KSCC1302).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic solitary lesions']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: BACKGROUND: Little is known about circadian variations of macronutrients content of expressed preterm @entity1 milk (HM). This study evaluated diurnal variations of macronutrients and energy content of preterm HM over the first 7 weeks of lactation and tested the hypothesis that values obtained during a morning sample are predictive of those obtained from an evening sample. MATERIALS AND METHODS: Expressed HM was obtained from 32 mothers of preterm @entity1 (26-33 weeks in gestational age), who routinely expressed all their milk every 3 hours from the beginning of the second to the seventh week after delivery. One aliquot was obtained from the first morning expression and the second from the evening expression. Energy and macronutrients contents were measured using an HM analyzer. RESULTS: Mean fat and energy contents of all samples obtained during the whole period were significantly higher in evening samples (p<0.0001). There were no significant differences between morning and evening @entity3363 and protein contents. Concentrations of protein, @entity3363 , and fat from morning samples were predictive of evening concentrations to different extents (R(2)=0.720, R(2)=0.663, and R(2)=0.20, respectively; p<0.02). The predictability of evening values by morning values was not influenced by the week of lactation at sampling or by individual @entity1 . In repeated-measures analysis of variance performed on 11 @entity1 who completed the whole 7-week period, over time, there was a significant decrease in fat, energy, and protein contents, whereas @entity3363 content remained unchanged. Day-night differences remained significant only for fat content. CONCLUSIONS: Circadian variations in fat and energy concentrations of HM are consistent over the first 7 weeks of lactation. There are no consistent circadian variations in HM protein and @entity3363 . Over a given day, there are little variations in protein and @entity3363 content, but fat concentrations are more variable, and evening values are less well predicted by morning sample analysis than values for protein or @entity3363 .

title: Circadian Macronutrients Variations over the First 7 Weeks of XXXX Milk Feeding of Preterm @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'infants']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: OBJECTIVE: Over the past decade, our institution has instituted three different scheduling models in an attempt to care for pediatric @entity130 at our Level I @entity130 Center. This has been in response to a number of factors, including a limited number of physicians covering the call schedule, increasing competition for operating room (OR) time after hours (pediatric surgery, urology, neurosurgery), an attempt to fully utilize OR time during the daytime, fully staffed hours, and optimizing @entity1 ' timeliness to surgery. We examined the three on-call systems in place at our institution to determine whether a more flexible approach to pediatric @entity130 call resulted in delays in treatment. METHODS: We retrospectively reviewed @entity1 records for three distinct 1-year periods with three different surgical call schedules: (i) a traditional call schedule in which the call physician was responsible for @entity1 who presented to our emergency room; (ii) a half-day @entity616 OR reserved the morning following call; and (iii) a full-day @entity616 . Variables included date of injury, time of admission, admission diagnosis, cause of injury, and OR procedure and start time. RESULTS: We reviewed 951 cases over the entire study, 268 during the traditional call schedule, 282 during the half-call block and 401 over the time period of the full-day block. @entity130 were similar among the three groups, with falls and motor vehicle accidents being the leading causes. The average delay time was 17:40 for the traditional call group, 15:10 for the half-block call group, and 15:09 for the full-day block group. Our findings suggest that there was a high incidence of cases performed on weekdays after peak staffing hours with a traditional call model (59%). In contrast, half-day and full-day block models saw only 4% and 1% of the cases performed after peak staffing hours, respectively. There was a statistically significant difference in the number of @entity1 admitted to the OR among the three groups (  (2) = 488.8449, P < 0.0001). The number of @entity1 seen during Monday through Friday was also statistically significant among the three groups (  (2) = 382.0576, P < 0.0001). CONCLUSIONS: The institution of more flexible and physician-directed half-call and full-day blocks did result in delays in treatment. However, it also has demonstrated benefits to @entity1 in reducing the number of operative cases performed after weekday peak staffing hours; helped our institution better manage its staffing and financial resources; and provided the treating surgeon flexibility in determining the timing of operative care.

title: Utilization of Orthopaedic @entity130 Surgical Time: An Evaluation of Three Different Models at a Level I Pediatric XXXX Center.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['trauma block']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'Mechanisms of injury', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: OBJECTIVE: Evaluation of the long-term @entity1799 /18 AS04-adjuvanted vaccine immunogenicity persistence in @entity1 . DESIGN: Multicentre, open-label, long-term follow-up (NCT00947115) of a primary phase-III study (NCT00196937). SETTING: Six centres in Germany and Poland. POPULATION: 488 healthy @entity1 (aged 15-55  years, age-stratified into groups: 15-25, 26-45, and 46-55  years) who received three vaccine doses in the primary study. METHODS: Immune responses were evaluated in serum and cervicovaginal secretion (CVS) samples 6  years after dose 1. Anti-HPV-16/18 geometric mean titres (GMTs) were measured by enzyme-linked immunosorbent assay (ELISA), and were used to fit the modified power-law and piecewise models, predicting long-term immunogenicity. @entity137 ( @entity137 ) were recorded. MAIN OUTCOME MEASURES: Anti-HPV-16/18 seropositivity rates and GMTs 6  years after dose  1. RESULTS: At 6  years after dose 1, all @entity1 were seropositive for anti-HPV-16 and >= 97% were seropositive for anti-HPV-18 antibodies. GMTs ranged from 277.7 to 1344.6  EU/ml, and from 97.6 to 438.2  EU/ml, for anti-HPV-16 and anti-HPV-18, respectively. In all age groups, GMTs were higher (anti-HPV-16, 9.3-45.1-fold; anti-HPV-18, 4.3-19.4-fold) than levels associated with natural infection (29.8  EU/ml). A strong correlation between serum and CVS anti-HPV-16/18 levels was observed, with correlation coefficients of 0.81-0.96 (anti-HPV-16) and 0.69-0.84 (anti-HPV-18). Exploratory modelling based on the 6-year data predicted vaccine-induced anti-HPV-16/18 levels above natural infection levels for at least 20  years, except for anti-HPV-18 in the older age group (piecewise model). One vaccine-related and two fatal @entity137 were reported. CONCLUSIONS: At 6  years after vaccination, immune responses induced by the @entity1799 /18 AS04-adjuvanted vaccine were sustained in all age groups.

title: Persistence of immune responses to the XXXX /18 AS04-adjuvanted vaccine in @entity1 aged 15-55  years and first-time modelling of antibody responses in mature @entity1 : results from an open-label 6-year follow-up study.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['SAEs', 'Serious adverse events']

answer: @entity1799 :: (333760,Species) :: ['HPV-16']


abstract: A large outbreak with an @entity4028 -resistant @entity7100 (AREC) clone occurred at the University Medical Center Utrecht beginning in 2001 and continued up through the time that this study was completed. This clone (genotype I) contains a conjugative R plasmid carrying the qnrA1, bla( @entity3525 -M-9), and aadB genes, encoding resistance to @entity5176 , extended-spectrum beta-lactamases, and @entity581 , respectively. The aim of this study was to determine whether this clone was more transmissible than other AREC strains. Therefore, the dissemination of this genotype and of other @entity7100 strains was studied. In addition, infection control measures taken were evaluated. Pulsed-field gel electrophoresis analysis divided the 191 AREC strains into 42 different genotypes, of which 5 (12%) involved at least three @entity1 . Aside from this outbreak (133 @entity1 ), only two other small outbreaks occurred, showing that the infection control measures were successful for all strains but one. Among 324 @entity4028 -susceptible @entity7100 strains, 34/166 (20%) genotypes were identified from at least three @entity1 , but only 4 involved small outbreaks. The outbreak strain was also detected in 11 of 15 other Dutch hospitals and caused outbreaks in at least 4. Evaluation of infection control measures showed that the outbreak strain disseminated throughout the hospital despite adequate implementation of internationally accepted guidelines on the control of multidrug-resistant Enterobacteriaceae (MRE). In conclusion, some MRE strains are better able to spread than others, and these strains may not be controlled by the current infection control guidelines. Strategies to identify such strains in an early phase and adapted guidelines for such "superbugs" are needed to prevent these clones from becoming endemic.

title: Failure to control an outbreak of qnrA1-positive multidrug-resistant XXXX infection despite adequate implementation of recommended infection control measures.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones']

entities_list: @entity7100 :: ('550', 'Species') :: ['Enterobacter cloacae', 'E. cloacae']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity4028 :: ('CHEBI:47779', 'Chemical') :: ['aminoglycoside']

answer: @entity7100 :: (550,Species) :: ['Enterobacter cloacae']


abstract: Objective: The link between stress-related increases in inflammatory markers, hepcidin, and @entity68 status are poorly understood, especially in developing countries like India. The aim of the study was to examine the relationship between adolescent life-event stress (ALES), inflammatory markers, and its association with hepcidin and biomarkers of @entity68 status among adolescent @entity1 . Methods: Data pertaining to a subsample of 145 @entity1 from a cross-sectional, school-based study recruiting 370 adolescent @entity1 aged 15-19  years, from 5 schools in Hyderabad, India, were analyzed. Stress was assessed using the ALES scale, @entity458 by the General Health Questionnaire-2 (GHQ-12), and approach and avoidance coping using the Coping Strategies Scale. Biomarkers of @entity68 and concentrations of other micronutrients, hepcidin, @entity650 and @entity1851 ( @entity1851 ) in plasma were analyzed. Data were subjected to regression, path analyses, and analysis of covariance (ANCOVA). Results: ALES was a significant predictor of interleukin (IL)-6 (b = 0.196, p = 0.012), @entity1851 (b = 0.217, p = 0.010), and log hepcidin (b = 0.228, p = 0.006). Hepcidin correlated significantly (p < 0.001) with @entity650 (r = 0.344) and @entity1851 (r = 0.370) but not with the biomarkers of @entity68 status. Path analysis showed that the model had an acceptable fit, with a root mean square error of approximation of 0.019, 90% confidence interval (CI) of 0.00-0.074, comparative fit index of 0.988, chi-square p = 0.393, and chi-square/df of 1.053. Conclusions: Adolescent life-event stress is associated with elevated @entity650 and hepcidin concentration but not hypoferremia. These findings may help in @entity68 supplementation programs for tackling @entity417 .

title: Adolescent Life-Event Stress in @entity1 Is Associated with Elevated XXXX and Hepcidin but Not Hypoferremia.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'boys']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity650 :: (3569,Gene) :: ['IL-6']


abstract: BACKGROUND AND OBJECTIVE: To evaluate the use of intravitreal @entity15127 in the treatment of @entity1940 secondary to @entity1020 ( @entity1020 ) in treatment-naive @entity1 . @entity1 AND METHODS: In a consecu-tive, retrospective case series, treatment-na  ve @entity1 with exudative @entity1020 were treated with intravitreal @entity15127 . Intravitreal injections were typically given every 6 weeks at the discretion of the treating physician. Snellen visual acuity (VA), clinical course, and adverse events were monitored. A minimum of three @entity15127 injections were given. Retreatment criteria included persistent submacular fluid, macular @entity4 , new macular @entity548 , and @entity1018 . RESULTS: The average change in VA for all lesions was a loss of 2.9 lines. Fifteen (14%) @entity1 gained more than 3 lines of VA. The average number of in-jections was 4.8. Ninety-two of 111 lesions were able to be categorized by size. Sixty-six @entity1 had small lesions (< 4 disc areas) with an average change of -2.0 lines, and 26 had large lesions (> or = 4 disc areas) with an average change of -5.4 lines (P < .02). @entity1 with larger lesions were at greater risk for severe @entity227 (P < .01). The average follow-up was approximately 31 weeks (range: 12 to 82 weeks) after the first injection. CONCLUSIONS: @entity15127 therapy resulted in a 2.9 average line loss in @entity1 when all lesions were considered. Small lesions responded favorably, with 15% of @entity1 gaining more than 3 lines of VA. Larger lesions had an increased risk of progression and poor visual outcome.

title: @entity15127 for XXXX in treatment-na  ve exudative @entity1020 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['loss of vision']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity1940 :: ('MESH:D020256', 'Disease') :: ['choroidal neovascularization']

entities_list: @entity15127 :: ('MESH:C495058', 'Chemical') :: ['Pegaptanib', 'pegaptanib']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['AMD', 'age-related macular degeneration']

answer: @entity1940 :: (MESH:D020256,Disease) :: ['choroidal neovascularization']


abstract: In this study, we examined the relationship between maternal @entity1017 induced by protein-and-energy restriction (PER) and pregnancy outcome. We also evaluated whether PER would potentiate the developmental @entity137 of @entity786 (CP) and @entity1862 (HU). Two independent experiments--employing two different methods of inducing protein-and-energy malnourishment-were performed. In the first experiment, well-nourished (fed ad libitum, normal diet, 22% of protein, 11.9 kJ/g) and food restricted (fed approximately half of ad libitum food intake, i.e. 12 g/day) @entity35 received CP (0, 5 and 7.5 mg/kg sc) on pregnancy day 11. In the second experiment, well-nourished (normal diet, 24% of protein, 12.4 kJ/g) and malnourished (protein-and-energy deficient diet, 8% of protein, 6.2 kJ/ @entity35 received HU (0, 300 and 500 mg/kg ip) on pregnancy day 11. PER alone caused pronounced reductions of pregnancy @entity1017 and low fetal body weight, but induce no embryolethality and, except for a few sternum anomalies, no @entity600 . PER attenuated embryolethal and teratogenic effects of CP. PER reduced @entity21258 but did not alter effects of HU on embryolethality and fetal body weight. Therefore severe maternal @entity1017 are not necessarily associated to embryolethality and terata and PER attenuates the teratogenic effects of CP and HU.

title: Maternal protein-and-energy restriction reduces the developmental XXXX of @entity786 and @entity1862 in @entity35 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1862 :: ('MESH:D006918', 'Chemical') :: ['hydroxyurea']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain', 'weight gain deficits']

entities_list: @entity21258 :: ('MESH:C535542', 'Disease') :: ['teratogenicity']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: Connexins form a family of membrane proteins that assemble into communication channels and directly connect the cytoplasms of adjoining cells. Malfunctioning of connexin channels often cause disease, such as the mutations @entity6384 and @entity62981 in @entity1 @entity3492 , which are associated with @entity74 . Another residue known to be essential for normal channel activity in the connexin is @entity2569 -64. To obtain structural and functional insights of @entity3492 , we studied the roles of these three residues by expressing mutant connexins in insect Sf9 and HeLa cells. The @entity6384 and @entity62982 mutants both formed gap junction plaques, but dye transfer assays showed that the @entity62982 mutant had a significantly reduced permeability, suggesting that for proper channel function a side chain of adequate size is required at this position. We propose that Met-34 is located in the innermost helix of the channel, where it ensures a fully open channel structure via interactions with other transmembrane helices. Gap junction channels formed by the @entity62981 and @entity62983 mutants dissociated upon solubilization in @entity10940 , whereas the @entity62984 mutant remained hexameric. All gap junctions formed by @entity534 -75 mutants also showed only negligible activity in dye transfer experiments. These results suggest that residue @entity534 -75 plays a role in subunit interactions needed to retain a functional and stable connexin hexamer. The @entity62985 mutant was suggested to be defective in oligomerization and/or protein folding even in the presence of wild-type connexin.

title: Roles of Met-34, @entity2569 -64, and @entity534 -75 in the assembly of XXXX @entity3492 . Implication for key amino acid residues for channel formation and function.

entities_list: @entity62981 :: ('p|SUB|R|75|W', 'ProteinMutation') :: ['R75W']

entities_list: @entity6384 :: ('p|SUB|M|34|T', 'ProteinMutation') :: ['M34T']

entities_list: @entity62982 :: ('p|SUB|M|34|A', 'ProteinMutation') :: ['M34A']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['hereditary deafness']

entities_list: @entity10940 :: ('MESH:C040358', 'Chemical') :: ['dodecyl maltoside']

entities_list: @entity62983 :: ('p|SUB|R|75|D', 'ProteinMutation') :: ['R75D']

entities_list: @entity62985 :: ('p|SUB|C|64|S', 'ProteinMutation') :: ['C64S']

entities_list: @entity62984 :: ('p|SUB|R|75|A', 'ProteinMutation') :: ['R75A']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Field experiments were conducted at Cereal Crops Research Institute, Pirsabak, Nowshera, Pakistan, during winter 2003-2004 and 2004-2005 to evaluate the effect of @entity1568 and @entity599 levels and methods of @entity1568 application on canola ( @entity4335 . cv. Bulbul-98) under rainfed conditions. Four levels of S (0, 10, 20, and 30 kg/ha) and three levels of N (40, 60, and 80 kg/ha) and a control treatment with both nutrients at zero level were included in the experiments. @entity599 levels were applied at sowing while N levels were applied by three methods (100% soil application, 90% soil+10% foliar application, and 80% soil +20% foliar application). The experiments were laid out in randomized complete block (RCB) design having four replications. Oil content increased significantly up to 20 kg S/ha but further increase in S level did not enhance oil content. @entity17645 content increased from 13.6 to 24.6 micromol/g as S rate was increased from 0 to 30 kg/ha. Protein content increased from 22.4% to 23.2% as S rate was increased from 0 to 20 kg/ha. Oil content responded negatively to the increasing N levels. The highest N level resulted in the highest values for protein (23.5%) and @entity17645 (19.9 micromol/g) contents. Methods of N application had no significant impact on any parameters under study.

title: Influence of @entity1568 and XXXX fertilization on quality of canola ( @entity4335 .) under rainfed conditions.

entities_list: @entity599 :: ('MESH:D013455', 'Chemical') :: ['sulfur', 'Sulfur']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity17645 :: ('CHEBI:24279', 'Chemical') :: ['glucosinolate', 'Glucosinolate']

entities_list: @entity4335 :: ('3708', 'Species') :: ['Brassica napus L']

answer: @entity599 :: (MESH:D013455,Chemical) :: ['sulfur']


abstract: OBJECTIVE: High risk and a long hospitalization time are often quoted as negative aspects of @entity146 surgery in @entity4327 . We did a retrospective analysis evaluating outcome and duration of hospitalization in @entity1 treated according to an @entity146 schedule. METHODS: Since 1989 we have treated 101 @entity1 with @entity4327 (72 males, 29 females; mean age 50.3 years, range 11-91 years; 77 metapneumonic @entity3509 , 24 @entity3509 following @entity130 or abdominal surgery). Sixty-nine @entity1 had had unsuccessful conservative pre-treatment (antibiotics, thorcozentses, drainage/irrigation, VATS). Thirty-one were critically ill @entity1 . In eight cases a seropurulent stage of @entity3509 was present, 17 @entity1 had fibrinous membranes, 30 an organizing stage with and 46 without well identifiable dissection plane. Eighty-five @entity1 proceeded to thoracotomy. @entity1997 or indurative @entity55 necessitated wedge-resection, lobectomy, or pneumonectomy in 29 cases. In the presence of gross necroses or callosities not amenable to decortication primary open-window thoracostomy (n = 22) was carried out. In six cases a secondary open-window thoracostomy was carried out because of persisting putrid secretion and @entity295 persisting after decortication or after drainage. The thoracostomy was closed when clean granulative tissue developed. Sixteen @entity1 underwent only drainage and irrigation because of an early stage or because of a general condition not permitting thoracotomy. RESULTS: Three @entity1 died due to severe @entity295 not responding to treatment, one had fatal @entity548 from a duodenal @entity1066 (mortality rate 3.9%). The others were able to resume their preoperative activities. The median duration of hospitalization was 14 days (mean 21.1 days; @entity8448 .7 days). CONCLUSION: Aggressive surgery for @entity4327 beyond the seropurulent stage ensures rapid relief from @entity295 at a low mortality rate even in very ill @entity1 .

title: Is @entity146 surgery in XXXX justified?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1997 :: ('MESH:D008169', 'Disease') :: ['Pulmonary abscesses']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity4327 :: ('MESH:D016724', 'Disease') :: ['pleural empyema']

answer: @entity4327 :: (MESH:D016724,Disease) :: ['pleural empyema']


abstract: @entity2407 , which is characterized by intense cold-induced @entity15496 of cutaneous arteries, is more common in @entity1 compared with @entity1 . Cold-induced @entity15496 is mediated in part by enhanced activity of @entity27888 )-adrenoceptors ( @entity27888 )-ARs) located on vascular smooth muscle cells (VSMs). Experiments were therefore performed to determine whether @entity53 regulates @entity27888 )-AR expression and function in cutaneous VSMs. @entity53 (0.01-10 nmol/l) increased expression of the @entity27888 )-AR protein and the activity of the @entity27888 )-AR gene promoter in @entity1 cultured dermal VSMs, which was assessed following transient transfection of the cells with a promoter-reporter construct. The effect of @entity53 was associated with increased accumulation of @entity268 and activation of the @entity268 -responsive @entity14825 GTP-binding protein. Transient transfection of VSMs with a dominant-negative mutant of @entity14825 inhibited the @entity53 -induced activation of the @entity27888 )-AR gene promoter, whereas a constitutively active mutant of @entity14825 increased @entity27888 )-AR promoter activity. The effects of @entity53 were inhibited by the @entity172 receptor (ER) antagonist, @entity1299 (1 micromol/l), and were mimicked by a cell-impermeable form of the hormone ( @entity172 :BSA) or by the selective @entity1782 receptor agonist @entity23849 ( @entity3445 ; 10 nmol/l) or the selective ER-beta receptor agonist @entity23850 ( @entity2125 ; 10 nmol/l). Therefore, @entity53 increased expression of @entity27888 )-ARs by interacting with cell surface receptors to cause a @entity268 / @entity14825 -dependent increase in @entity27888 )-AR transcription. In @entity19 tail arteries, @entity53 (10 nmol/l) increased @entity27888 )-AR expression and selectively increased the cold-induced amplification of alpha(2)-AR @entity15496 , which is mediated by @entity27888 )-ARs. An @entity172 -dependent increase in expression of cold-sensitive @entity27888 )-ARs may contribute to the increased activity of cold-induced vasoconstriction under @entity172 -replete conditions.

title: XXXX increases smooth muscle expression of alpha2C-adrenoceptors and cold-induced @entity15496 of cutaneous arteries.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity23850 :: ('MESH:C486182', 'Chemical') :: ['2,3-bis(4-hydroxyphenyl)-propionitrile']

entities_list: @entity2407 :: ('MESH:D011928', 'Disease') :: ["Raynaud's phenomenon"]

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol', '17beta-Estradiol']

entities_list: @entity15496 :: ('MESH:D015877', 'Disease') :: ['constriction']

answer: @entity172 :: (MESH:D004967,Chemical) :: ['Estrogen']


abstract: @entity35837 and @entity42364 / @entity42364 , two members of the TIF1 family of nuclear cofactors, are ubiquitous co-regulators of nuclear receptors and KRAB motif-containing zinc finger transcription factors, respectively. Despite the functional evidence suggesting a role for TIF1 proteins as modulators of transcription, the study of their interactions with transcriptional machineries in physiologically relevant systems has been difficult. Here, we have developed a bioluminescence resonance energy transfer (BRET) biophysical approach to study protein-protein interactions in the nuclear compartment of living @entity1 cells. We report that @entity35837 and @entity42364 form homo- and hetero-oligomers in intact @entity1 cells. BRET titration experiments indicate that both homo- and hetero-oligomers occur with relatively high affinity suggesting that they could co-exist in cells. Furthermore, we demonstrate that @entity42364 but not @entity35837 interacts with the KRAB multifinger @entity63802 in the nuclear matrix. Splice variants and point mutants of @entity63802 that lack transcriptional activity were found not to interact with @entity42364 confirming the physiological importance of this interaction in living cells. The interaction of @entity63802 with @entity42364 did not prevent @entity42364 homomerization indicating that the oligomers most likely represent the transcriptionally active species. Furthermore, the detection of ternary @entity63802 . @entity42364 . @entity35837 complexes suggests the existence of cross-talk between @entity42364 -interacting KRAB proteins and @entity35837 -interacting nuclear receptors. In addition to providing new insights into the molecular interactions involved in the transcriptional activities of these proteins, this study shows that BRET can be advantageously used as a non-transcription-based oligomerization detection system to study the interaction of transcriptionally active proteins, including nuclear matrix proteins, in living cells.

title: Oligomerization of transcriptional intermediary factor 1 regulators and interaction with XXXX nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity35837 :: ('8805', 'Gene') :: ['TIF1alpha', 'Transcriptional intermediary factor 1 (TIF1) alpha']

answer: @entity63802 :: (7625,Gene) :: ['ZNF74']


abstract: It is generally accepted that hemifacial @entity2473 (HFS) is caused by vascular compression at the root exit zone (REZ) of the facial nerve. We saw an HFS @entity1 caused by vascular compression of the distal portion of the facial nerve associated with configuration variation of the @entity4237 complex. A 50-year-old female with left HFS was admitted to our hospital. Preoperative magnetic resonance image demonstrated no offending artery around the facial nerve at the nerve's REZ. Microvascular decompression of the @entity2103 was performed via a lateral suboccipital infrafloccular approach. The facial nerve arose more than 5 mm away from the vestibulocochlear nerve in the brain stem and both traveled apart toward the internal acoustic meatus in the cerebello-pontine cistern. No offending vessel was observed near the REZ of the facial nerve. The abnormal muscle responses of the mentalis muscle disappeared when the AICA was separated from the distal portion of the facial nerve. The @entity1 was completely free of the HFS following surgery. The facial nerve arising away from the vestibulocochlear nerve in the brain stem is rare. It might influence the cause of HFS with compression of the distal portions of the seventh @entity129 .

title: Hemifacial XXXX caused by vascular compression of the distal portion of the facial nerve associated with configuration variation of the facial and vestibulocochlear nerve complex.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['left seventh cranial nerve']

entities_list: @entity4237 :: ('MESH:D000160', 'Disease') :: ['facial-vestibulocochlear nerve']

answer: @entity2473 :: (MESH:D013035,Disease) :: ['spasm']


abstract: OBJECTIVE: To assess the co-morbidity of @entity148 and @entity308 in hospitalized @entity1 and to analyze the degree of symptoms and the influential factors. METHODS: Thirty @entity1 with @entity5 were injected with thymosin alpha 1 subcutaneously at the dose of 1.6 mg q.d. for the first month and q.o.d. for the following month. The number of T cell subgroups and the activity of NK cell in peripheral blood were detected and the quality of life of the @entity1 were evaluated before treatment and at the end of treatment. RESULT: (1) About 39.9 % of the @entity1 presented the symptoms of @entity148 and @entity308 and out of them 6.7 % were taken psychotropic medication. (2) Stepwise Logistic Regression showed that the factors related to @entity148 and @entity308 could be classified into four categories: economic factor, sleeping status, @entity73 , the other factors such as course of disease and the environment of hospital. (3) Data analysis of oncology @entity1 showed that the @entity73 would be an important factor, which would affect @entity148 and @entity308 status. CONCLUSION: Multiple factors can affect @entity148 and @entity308 symptoms of inpatients. The results suggest that psychological intervention such as cognitive therapy should be considered in clinical practice.

title: [Study on XXXX and @entity308 of inpatients in general hospital].

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumor']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognition of disease']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: OBJECTIVE: To examine the antagonistic interactions between @entity2042 and Exorchis ovariolobularis in the snail host, @entity12510 . METHODS: The infection rate and average number of cercariae of @entity2043 were examined in @entity12510 which had been superinfected with @entity2043 and E. ovariolobularis. The experimental snails were histologically observed by @entity982 section. RESULTS: When snails were fed with eggs of E. ovariolobularis 37 days later than @entity2043 infection, the infection rate of @entity2043 (52.9%) was significantly lower than that of the single @entity2043 infected control (75.9%). When E. ovariolobularis infected snails were exposed to @entity2043 miracidia at different intervals, the infection rates of @entity2043 were 64%, 66.7%, 65.2%, 56.4% and 57.1%, respectively. On the other hand, the infection rate of @entity2043 in the single infected control was 90.5%. There existed significant differences. Furthermore, the average number of @entity2043 cercariae shed from superinfected snails were significantly less than that of single @entity2043 infected control. The histological observation showed that the larvae of @entity2043 in superinfected snails were sluggish in development, irregular, shrunken, deformed, relatively small in number as compared with the control. The sporocysts contained few germ balls or immature cercariae and most of the digestive glands of superinfected snails were atrophied. CONCLUSION: There is antagonism between E. ovariolobularis and @entity2043 in @entity12510 , and E. ovariolobularis is dominant in this situation.

title: Studies on antagonism between Exorchis ovariolobularis and XXXX in @entity12510 .

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity2042 :: ('6182', 'Species') :: ['Schistosoma japonicum']

entities_list: @entity12510 :: ('56141', 'Species') :: ['O. hupensis', 'Oncomelania hupensis']

answer: @entity2042 :: (6182,Species) :: ['Schistosoma japonicum']


abstract: Advanced glycation end products (AGEs) may promote @entity32 by interacting with the receptor for advanced glycation end products. Serum soluble receptor for advanced glycation end products (sRAGE), a form of receptor for advanced glycation end products thought to mediate AGE's inflammatory properties, is @entity6 and @entity453 . Evidence in older adults suggests that sRAGE is depressed in individuals without current disease who are @entity28 ; however, 2 studies have failed to find this correlation. We hypothesized that sRAGE would be inversely correlated with @entity1386 and positively correlated with @entity32 , even in apparently healthy, young adults. By considering adults of body mass index (BMI) varying from normal weight to overweight and @entity28 , we aimed to define how closely AGEs and sRAGE correlate with @entity1386 and other indicators of metabolic stress. Anthropometric measurements and fasting blood samples were obtained from @entity1 (n = 69). Sera were analyzed for sRAGE, @entity11461 , a measure of AGEs, and high sensitivity C-reactive protein. High molecular weight adiponectin, @entity413 , insulin, total @entity165 , high-density lipoprotein, and @entity1674 were also assessed (n = 32). Spearman rank correlations were used to evaluate the relationship among indicators of @entity1386 and biochemical indicators of metabolic health and @entity32 . Factors inversely correlated with sRAGE include weight (Rs = -0.397; P = .001), waist circumference (-0.291; P = .015), and BMI (-0.3338; P = .004). High molecular weight adiponectin was positively correlated with sRAGE, and predictors of sRAGE included BMI and total @entity165 . This is the first time these associations have been found in a diverse population of young adults.

title: Serum soluble receptor for advanced glycation end products correlates inversely with measures of XXXX in young adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['decreased in diabetes mellitus']

entities_list: @entity11461 :: ('CHEBI:53014', 'Chemical') :: ['n-epsilon carboxy-methyl-lysine']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triacylglycerol']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1386 :: (MESH:D018205,Disease) :: ['adiposity']


abstract: BACKGROUND: Chronic placental pathologic processes such as fetal @entity715 have been linked to @entity1545 in neonates. We hypothesize that using stillbirth as a model, placental pathology can predict risk for @entity2806 . DESIGN: From a single institutional database of stillbirths {greater than or equal to}23 weeks gestational age, we included cases with full autopsy and neuropathology examination. Bivariable analyses were performed to identify whether there was an association between placental pathologic findings and neuropathologic findings. Logistic regression was used to control for potential confounders. RESULTS: Among 97 potential cases, adequate tissue was analyzable from 79 cases (mean gestational age 33 weeks). Acute CNS @entity548 and @entity7592 were the most common neuropathologic processes seen in this cohort (57% for each). Maternal vascular underperfusion was the most common placental pathology, but was not significantly associated with a specific neuropathologic finding. High grade chronic villitis (HGCV) and fetal @entity715 (FTV) were significantly associated with increased risk for pontosubicular @entity39 (OR 15.73 and 3.79, respectively). These associations persisted after controlling for potential confounders. CONCLUSION: Chronic placental pathologies, specifically HGCV and FTV, were associated with pontosubicular @entity39 , suggesting that placental pathology involving the fetal vasculature and altered fetoplacental blood flow have the greatest likelihood of @entity519 / @entity63 @entity1545 .

title: Stillbirth: Correlations Between XXXX and Placental Pathology.

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic-ischemic brain injury']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity7592 :: ('MESH:D015882', 'Disease') :: ['acute neuronal necrosis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic vasculopathy']

answer: @entity1545 :: (MESH:D020214,Disease) :: ['Brain Injury']


abstract: INTRODUCTION: Acute presentation of @entity11034 is a rare condition with a high mortality for acute ischaemia. This study was undertaken to investigate the acute management, diagnosis, and long-term outcomes of @entity1 presenting with @entity11034 . METHODS: Cases were reviewed retrospectively from 2004 to 2014. @entity1 presenting as an emergency admission with @entity11034 were included. RESULTS: Thirty-six @entity1 were included, five of whom had previous surgery. The mean age was 71  years old. All @entity1 presented with @entity391 and chest/ @entity158 . CT was diagnostic in all 26 @entity1 . Barium swallow was diagnostic in two/four @entity1 . @entity23258 was diagnostic in 9 of 20 @entity1 . All @entity1 had an NG tube placed, and eight @entity1 were treated conservatively and made a full recovery. Twenty-nine @entity1 proceeded to surgery. Nine had a laparoscopic repair with two open conversions. Four @entity1 had @entity39 , and all had open surgery with resection. Three @entity1 had a mediastinal perforation, and one @entity1 required an additional thoracotomy. All @entity1 with viable stomach had a hiatal repair (where appropriate), 11 had a gastropexy, and 11 had a fundoplication. Mortality for @entity39 /perforation was 30  %. Mean postoperative stay was 4  days for laparoscopic repair and 8  days for uncomplicated open surgery. Nine of twenty-nine had transient @entity1282 postoperatively. Three of eight @entity1 treated conservatively had an elective procedure subsequently. CONCLUSIONS: Acute @entity357 requires early resuscitation and diagnosis. CT should be favoured in assessment, and an NG tube placed promptly. A conservative management may be considered safely in stable @entity1 . Surgical management should be prompt for unstable @entity1 . Gastric ischaemia or perforation has a mortality of 30  %. Laparoscopic repair has a shorter postoperative stay, but has a higher recurrence rate. Surgery for @entity1 without gastric ischaemia has good long-term outcomes with minimal morbidity.

title: The threatened stomach: management of the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['gastric necrosis']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity11034 :: ('MESH:D013277', 'Disease') :: ['acute gastric volvulus', 'gastric volvulus']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['paraoesophageal hiatus hernia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity11034 :: (MESH:D013277,Disease) :: ['acute gastric volvulus']


abstract: UNASSIGNED: Although reports documented aberrant cytokine expression in @entity792 ( @entity792 ), cytokine-targeting therapies have not been established in these disorders. We showed previously that @entity777 treatment protected against tissue destruction in experimental epidermolysis bullosa acquisita (EBA), an AIBD caused by autoantibodies to type VII collagen (COL7). The anti-inflammatory effects of @entity777 were mediated by induction of @entity18995 , and prophylactic @entity18995 administration prevented blistering. In this article, we demonstrate elevated serum concentrations of @entity635 in both @entity19 with experimental EBA induced by injection of anti-COL7 IgG and in EBA @entity1 . Increased @entity634 and @entity635 expression also was observed in the skin of anti-COL7 IgG-injected wild-type @entity19 compared with the significantly less diseased IL-1R-deficient or wild-type @entity19 treated with the IL-1R antagonist anakinra or anti- @entity635 . These findings suggested that @entity5003 contributed to recruitment of inflammatory cells into the skin. Accordingly, the expression of @entity8024 was decreased in IL-1R-deficient and anakinra-treated @entity19 injected with anti-COL7. This effect appeared to be specifically attributable to @entity5003 because anakinra blocked the upregulation of different endothelial adhesion molecules on @entity5003 -stimulated, but not on @entity637 -stimulated, cultured endothelial cells. Interestingly, injection of @entity13761 -deficient mice with anti-COL7 IgG led to the same extent of @entity272 as in wild-type @entity19 . Collectively, our data suggest that @entity5003 , independently of @entity13761 , contributes to the pathogenesis of EBA. Because anti- @entity635 in a prophylactic setting and anakinra in a quasi-therapeutic setting (i.e., when @entity272 had already developed) improved experimental EBA, @entity5003 appears to be a potential therapeutic target for EBA and related @entity792 .

title: @entity13761 -Independent XXXX Release Mediates Blister Formation in Autoantibody-Induced Tissue Injury through Modulation of Endothelial Adhesion Molecules.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune bullous dermatoses', 'AIBDs']

answer: @entity5003 :: (111343(Tax:10090),Gene) :: ['IL-1']


abstract: INTRODUCTION: Current approaches to quantifying the severity of @entity1408 require internal measurements based on cross-sectional imaging. This study evaluated the modified percent depth (MPD), a novel index of severity that can be obtained with external measurements, potentially avoiding the need for cross-sectional imaging. METHODS: @entity1 undergoing surgical repair of @entity1408 (pectus group), and those undergoing cross-sectional imaging for unrelated reasons (control group), between 2010 and 2016 were included. The MPD of the deformity was calculated using external (i.e. skin surface to skin surface) measurements from the radiographic images. The same external measurements were taken using chest calipers on a subset of these @entity1 in the outpatient clinic. The optimal threshold for MPD that defined severe @entity85 was derived from receiver-operator characteristic (ROC) analysis. Sensitivity and specificity of the MPD was compared with that of the Haller Index (HI) and Correction Index (CI). RESULTS: There were 92 @entity1 (49 pectus, 43 controls) included. The median MPD was 20.2% and 4.2% for pectus and control @entity1 , respectively (p<0.0001). An MPD cutoff of 10% optimally discriminated between severe pectus @entity1 and controls by ROC analysis. An MPD of >10% had 98% sensitivity and 98% specificity for severe @entity85 . Sensitivity and specificity were respectively 93% and 93% for HI >3.25, and 100% and 79% for CI >10. CONCLUSION: An MPD >10% performs slightly better than the HI and CI in distinguishing @entity1 with severe @entity85 . This novel measurement approach offers distinct advantages over existing indices, in that it does not require cross-sectional imaging and can be done using chest calipers in the office setting. Further studies with larger sample size are needed to verify reproducibility of the technique. LEVEL OF EVIDENCE: Level II, Study of Diagnostic Test.

title: The modified percent depth: Another step toward quantifying severity of XXXX without cross-sectional imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['pectus deformities', 'pectus deformity']

entities_list: @entity1408 :: ('MESH:D005660', 'Disease') :: ['pectus excavatum']

answer: @entity1408 :: (MESH:D005660,Disease) :: ['pectus excavatum']


abstract: AIM: The aim of this article is to evaluate the rate of @entity1 developing sustained @entity2790 (IOP) after ranibizumab (Lucentis) intravitreal (IVT) injections. DESIGN: This is a retrospective study. @entity1 : Charts of 192 consecutive @entity1 receiving Lucentis for @entity1020 ( @entity1020 ) were retrospectively reviewed. MATERIALS AND METHODS: We enrolled @entity1 with at least two IOP measurements between injections. Elevated IOP was defined as >21 mm Hg with an increase of at least 20% from baseline. Noninjected contralateral eyes of the same @entity1 cohort were used as control. MAIN OUTCOME MEASURES: Primary outcome was defined as elevated IOP. Secondary outcomes were presence and type of @entity726 , number of injections, and time to IOP elevation. RESULTS: Elevated IOP occurred at a significantly higher rate in eyes receiving IVT ranibizumab (7.47%; n = 9) compared with control (0.93%; n = 1). @entity1 with preexisting @entity726 or @entity2790 ( @entity2790 ) were more likely to develop elevated IOP after IVT ranibizumab injection. CONCLUSION: Intravitreal ranibizumab injections are associated with sustained IOP elevation in some eyes. HOW TO CITE THIS ARTICLE: Reis GMSM, Grigg J, Chua B, Lee A, @entity18282 R, Higgins R, Martins A, Goldberg I, Clement CI. The Incidence of Intraocular Pressure Elevation following Intravitreal Ranibizumab (Lucentis) for Age-related @entity1020 . J @entity726 Pract 2017;11(1):3-7.

title: Incidence of Intraocular Pressure Elevation following Intravitreal Ranibizumab (Lucentis) for Age-related XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'Curr Glaucoma']

entities_list: @entity2790 :: ('MESH:D009798', 'Disease') :: ['ocular hypertension', 'OHT', 'elevated intraocular pressure']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['Macular Degeneration', 'AMD', 'age-related macular degeneration']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['Macular Degeneration']


abstract: BACKGROUND: @entity15 ( @entity15 ), a progressive @entity17 and spinal cord, is the leading cause of nontraumatic @entity16 in young adults. Canada has one of the highest reported incidents of @entity15 , with estimates between 55 and 240 per 100,000 individuals. Between 2009 and 2014, the @entity15 Society of Canada provided over Can  90 million to researchers and, since 2013, has encouraged researchers to make both current and previous research products openly available. OBJECTIVE: The goal of the study was to determine the @entity1538 ( @entity1538 ) cost implications and repository policies of journals frequently used by a sample of @entity15 researchers. This study benchmarked current publishing preferences by @entity15 Society of Canada researchers by examining the @entity1538 full-text availability of journal articles written by researchers funded between 2009 and 2014. METHODS: Researchers were identified from the 2009 to 2014 annual @entity15 Society of Canada Research Summaries. Articles were identified through searches in Web of Science, Scopus, Medline and Embase (both via OVID). Journal level analysis included comparison of @entity1538 policies, including @entity11339 ( @entity11339 ) and repository policies. Data were analyzed using descriptive statistics. RESULTS: There were 758 articles analyzed in this study, of which 288 (38.0%) were @entity1538 articles. The majority of authors were still relying on journal policies for deposit in PubMed Central or availability on publisher websites for @entity1538 . Gold @entity1538 journals accounted for 10.2% of the journals in this study and were associated with significantly lower @entity11339 (US  1900) than in hybrid journals (US  3000). Review of the journal self-archiving options highlighted the complexity of stipulations that authors would have to navigate to legally deposit a version of their article. CONCLUSIONS: This study found that there are currently researcher- and publisher-imposed barriers to both the gold and green roads to @entity1538 . These results provide a current benchmark against which efforts to enhance openness can be measured and can serve as a reference point in future assessments of the impact of @entity1538 policies within this field. With funding agencies worldwide releasing @entity1538 mandates, future success in compliance will require changes to how researchers and publishers approach production and dissemination of research.

title: Public Funding and Open Access to Research: A Review of Canadian XXXX Research.

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelinating disease of the brain']

entities_list: @entity1538 :: ('MESH:D005902', 'Disease') :: ['open access', 'OA']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological damage']

entities_list: @entity11339 :: ('MESH:D058747', 'Disease') :: ['APCs', 'article processing charges']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['Multiple sclerosis', 'MS']

answer: @entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']


abstract: UNASSIGNED: OBJECT There is inconsistency among the perioperative management strategies currently used for @entity6087 ( @entity6087 ). Moreover, postoperative complications such as acute @entity510 and @entity6087 recurrence affect clinical outcome of @entity6087 surgery. This study evaluated the risk factors associated with acute @entity510 and @entity6087 recurrence and identified an effective perioperative strategy for @entity6087 @entity1 . METHODS A retrospective study of @entity1 who underwent bur hole craniostomy for @entity6087 between 2008 and 2012 was performed. RESULTS A consecutive series of 303 @entity6087 @entity1 (234 males and 69 females; mean age 67.17 years) was analyzed. Postoperative acute @entity510 developed in 14 @entity1 (4.57%) within a mean of 3.07 days and recurrence was observed in 37 @entity1 (12.21%) within a mean of 31.69 days (range 10-104 days) after initial bur hole craniostomy. The comorbidities of @entity1503 and prior shunt surgery were clinical factors associated with @entity548 . There was a significant risk of recurrence in @entity1 with @entity6 , but recurrence did not affect the final neurological outcome (p = 0.776). @entity954 , including the number of operative bur holes, saline irrigation of the @entity1410 cavity, use of a drain, and type of postoperative ambulation, were not significantly associated with outcome. However, a large amount of drainage was associated with postoperative @entity548 . CONCLUSIONS Bur hole craniostomy is an effective surgical procedure for initial and recurrent @entity6087 . @entity1 with @entity1503 or a history of prior shunt surgery are at risk for postoperative @entity548 ; therefore, these @entity1 should be carefully monitored to avoid overdrainage. Surgeons should consider informing @entity1 with @entity6 that this comorbidity is associated with an increased likelihood of recurrence.

title: Acute @entity510 and recurrence after bur hole craniostomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['acute bleeding']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['intracranial bleeding']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity6087 :: ('MESH:D020200', 'Disease') :: ['cSDH', 'chronic subdural hematoma']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological disease']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['Surgical details']

answer: @entity6087 :: (MESH:D020200,Disease) :: ['chronic subdural hematoma']


abstract: BACKGROUND AND OBJECTIVE: Photoselective vaporization of the prostate ( @entity12468 ) is an alternative to transurethral resection of the prostate in the surgical treatment of @entity1067 ( @entity1067 ). Our objective was to prospectively evaluate the feasibility, safety, and efficacy of ambulatory photoselective vaporization of the prostate for @entity1067 . MATERIALS AND METHODS: We prospectively collected data of all consecutive @entity1 who underwent ambulatory @entity12468 with the Greenlight(  ) laser 180-W XPS at two centers between May 2012 and June 2013. @entity1 ' characteristics, perioperative data, postoperative outcomes, complications, and @entity1 's satisfaction were evaluated. Successful ambulatory care procedure was defined as the ability to leave the hospital in the evening of the operation. RESULTS: The ambulatory procedure was intended in 134 @entity1 . Mean age was 67 years. Mean prostate volume was 54   ml, and Median American Society Anesthesiologists (ASA) score was 2. Ambulatory procedure was successful in 121 @entity1 (90%). At 3 months, International Prostate Symptom Score (7.3        4.9), maximal urinary flow rate (20.8        7.6   ml/s), postvoid residual urine (19.2        71   ml), and quality of life (1.6        1.4) were significantly improved (P   <   0.001). Fourteen @entity1 (10.5%) had complications that were all minor (Clavien    <=   2). Two @entity1 had to be readmitted to the hospital. The majority of @entity1 (89%) were satisfied with ambulatory care. Failure to complete ambulatory procedure was mostly related to logistical problem (70% of the cases). CONCLUSIONS: Ambulatory @entity12468 is feasible with functional results and complications comparable to that of traditional hospitalization. Ambulatory care yields high @entity1 's satisfaction. Lasers Surg. Med. 47:396-402, 2015.    2015 Wiley Periodicals, Inc.

title: Prospective evaluation of ambulatory laser vaporization of the prostate for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH']

answer: @entity1067 :: (MESH:D011470,Disease) :: ['benign prostatic hyperplasia']


abstract: BACKGROUND: @entity1582 with @entity712 is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of @entity296 Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were more sensitive than tissue Doppler and could detect early regional @entity296 before the onset of @entity712 ( @entity712 ) in @entity1 with @entity1582 (primary) @entity2783 . METHODS AND RESULTS: Ninety-seven biopsy-proven @entity1 with @entity1582 were divided into 3 groups. Group 1 @entity1 had no cardiac involvement (n=36), group 2 had heart involvement but no @entity712 (n=32), and group 3 had heart involvement and @entity712 (n=29). All @entity1 underwent tissue velocity (TV) imaging, strain, and strain rate imaging (SR) at the basal, mid, and apical ventricle in 2 apical views. With the use of TV, differences in systolic function were only apparent between group 3 (basal mean value, 3.0+/-1.1 cm/s) and groups 1 and 2 (5.0+/-1.3 and 4.6+/-1.2 cm/s, respectively). In contrast, basal peak systolic SR (l/s) showed significant differences among all 3 groups (-2.0+/-0.4, -1.55+/-0.6, and -0.76+/-0.3 for groups 1 to 3, respectively. P<0.01). Basal strain also demonstrated statistically significant differences among the groups (-19+/-4%, -15+/-4.5%, and -8.0+/-5%; P<0.01). CONCLUSIONS: @entity299 is characterized by an early @entity73 at a time when fractional shortening remains normal. This abnormality precedes the onset of @entity712 and can be detected by strain and SR but is not apparent by TV imaging.

title: Longitudinal myocardial function assessed by tissue velocity, strain, and strain rate tissue Doppler echocardiography in @entity1 with XXXX (primary) @entity299 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial strain', 'myocardial dysfunction']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF', 'heart failure']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment in systolic function']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['AL amyloidosis', 'AL']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Cardiac amyloidosis']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['AL']


abstract: UNASSIGNED: @entity1120 ( @entity1120 ) is an @entity74 , due to deficiency of the lysosomal enzyme glucocerebrosidase, leading to accumulation of the substrate @entity22138 in the cells of the macrophage-monocyte system. @entity1 with @entity1120 have alteration in their immune system and impaired microbicidal capacity of mononuclear phagocytes. It has also been demonstrated that monocyte dysfunction may correlate with the plasma glucocerebrosidase concentrations. @entity378 ( @entity378 ) is a major public health problem in developing countries. @entity3254 is one of the most common forms of @entity1907 . Since immune system can be impaired due to the @entity1120 in various ways, @entity378 can be observed in @entity1 with @entity1120 especially when left untreated. @entity1503 (s) is also general finding in untreated Gaucher @entity1 , and they may be observed most frequently due to the infiltration of the bone marrow with Gaucher cells together with the additional factor of @entity381 . We herein present a case of an adult @entity1 with heterozygous untreated GD1, who developed @entity3254 complicated by @entity3794 . Before his admission to our clinic, pleurectomy operation was performed and 4-drug combination anti- @entity378 therapy was initiated including @entity3109 , @entity1215 , @entity3110 and @entity5585 . @entity221 complaint was disappeared with anti- @entity378 treatment but he also had @entity1295 and @entity158 . After initiation of enzyme replacement therapy in addition to anti- @entity378 treatment, clinical and hematological improvement was observed. To our knowledge, this is the first reported case of GD1 with @entity3254 .

title: @entity3254 in a XXXX with untreated type 1 @entity1120 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patients', 'patients']

entities_list: @entity3110 :: ('MESH:D004977', 'Chemical') :: ['ethambutol']

entities_list: @entity5585 :: ('MESH:D011718', 'Chemical') :: ['pyrazinamide']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['extra-pulmonary TB']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['ipsilateral pulmonary fibrosis']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Cytopenia']

entities_list: @entity3109 :: ('MESH:D007538', 'Chemical') :: ['isoniazid']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal recessive glycolipid storage disorder']

entities_list: @entity1120 :: ('MESH:D005776', 'Disease') :: ['GD', 'deficiency of glucocerebrosidase', 'Gaucher disease']

entities_list: @entity22138 :: ('CHEBI:18368', 'Chemical') :: ['glucocerebroside']

entities_list: @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['Tuberculosis', 'TB']

entities_list: @entity3254 :: ('MESH:D014396', 'Disease') :: ['Pleural TB', 'pleural TB']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: RATIONALE: Longitudinal follow-up of @entity1 with @entity10485 is essential to improving our understanding of these disorders, yet currently, there is no such data. OBJECTIVES: To longitudinally define malacia sites and quantify the cross-sectional area (CSA) of the lumen using a bronchoscopic technique and to relate these measurements to illness profiles. METHODS: The validated color histogram mode technique was utilized to quantify primary malacia lesions and airway sites' CSA. Illness frequency, validated scales of illness and cough diary scores were prospectively used to assess clinical profiles. RESULTS: Thirty-five malacia sites were defined from the 2 studies of 21 @entity1 . CSA of 21 (60%) of the malacia lesions increased, 5 (14%) new lesions appeared, 5 (14%) decreased in size, 3 (8%) remained unchanged, and 1(3%) was indeterminate. Overall there was no statistically significant change in paired-data assessments of malacia sites' area while there was a significant increase in area of non-malacia sites. The median yearly growth rate for the malacia sites and non-malacia was 3.65 mm2/year sites and 5.38 mm2/year, respectively (P = 0.31). The type and severity of lesion was not associated with any difference in growth rates, illness frequency or clinical scores. CONCLUSIONS: @entity75 increase in size at the same rate as non-malacia sites. However malacia may worsen and new @entity75 may develop. Neither malacia type nor severity influences their growth pattern or illness profile.

title: Longitudinal quantification of growth and changes in primary XXXX sites in @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity10485 :: ('MESH:D055089', 'Disease') :: ['tracheobronchomalacia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesions', 'Malacia lesions']

answer: @entity10485 :: (MESH:D055089,Disease) :: ['tracheobronchomalacia']


abstract: PURPOSE: Keratocytes synthesize keratan-sulfate proteoglycans (KSPG), lumican and keratocan, to develop and maintain proper collagen interfibrillar spacing and fibril diameter characteristics of the transparent @entity267 . The purposes of this study are to compare the expression patterns of KSPGs and @entity15251 ( @entity15251 ) respectively by corneal keratocytes and epithelial cells after three different types of @entity130 ; partial and total epithelial debridement and alkali burn. METHODS: Corneas of 8-12 week old C57Bl/6J or FVBN @entity19 were wounded by partial epithelial (2 mm in diameter) and total epithelial debridement, and alkali burn (0.1 M @entity6674 , 30 s) and were allowed to heal for various periods of time, from 1 to 84 days. The corneas were then subjected to light microscopy, in situ and Northern hybridization and RT-PCR for examining the expression of @entity15251 and KSPG in the corneal epithelium and stroma, respectively. Immunohistochemistry with anti-alpha-smooth muscle actin ( @entity3113 ) was used to identify myofibroblasts in the stroma of injured @entity267 . RESULTS: In 2-3 days, partial epithelial denuded corneas were resurfaced by corneal epithelium positive for @entity15251 , and stromal @entity4 caused by debridement disappeared. Total epithelial debridement wounded corneas were resurfaced by conjunctival epithelial cells in 2 weeks. Stromal @entity4 in the total epithelial debridement corneas began to subside after 6 weeks. Corneal epithelial cells resurfaced alkali burned corneas within 3-5 days. In situ and Northern hybridization showed a decrease in keratocan and lumican expression at 6 weeks and increased at 12 weeks post-injury in all wound types. @entity3113 positive myofibroblasts in the @entity267 were detected via immunostaining at the time point when KSPG expression was lowest, 6 weeks post-injury. CONCLUSIONS: The results suggest keratocan and lumican are down-regulated during wound healing at 6 weeks and returned to higher levels at 12 weeks post-injury; implicating that the cells repopulating the injured corneal stroma regained the characteristic function of keratocytes independent of the wound types. However, @entity2543 in irreversible loss of @entity15251 expression.

title: Altered KSPG expression by keratocytes following XXXX .

entities_list: @entity2543 :: ('MESH:D017573', 'Disease') :: ['complete epithelial removal results']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity267 :: (MESH:D065306,Disease) :: ['corneal injury']


abstract: BACKGROUND: Monocular @entity1939 may be associated with bilateral horizontal @entity346 , a subtype of fusion @entity346 (FMNS). @entity1 often adopt a significant @entity135 ( @entity135 ) towards the fixing eye in order to dampen the @entity346 . This clinical entity has also been reported as @entity18368 . The aim of the study was to ascertain the clinical features and surgical outcome of @entity1 with FMNS with infantile unilateral @entity227 . METHODS: In this retrospective case series, nine consecutive @entity1 with FMNS with infantile unilateral @entity227 underwent strabismus surgery to correct an @entity135 and/or improve ocular alignment. Outcome measures included amount of @entity135 and deviation at last follow-up. RESULTS: Eye muscle surgery according to the principles of Kestenbaum resulted in a marked reduction or elimination of the @entity135 . On average, a reduction of @entity135 of 1.3  /mm was achieved by predominantly performing combined horizontal recess-resect surgery in the intact eye. In cases of existing @entity5971 ( @entity5971 ) this procedure also markedly reduced the angle of deviation. A dosage calculation of 3 prism diopters/mm was established. CONCLUSIONS: We advocate a tailored surgical approach in FMNS with infantile unilateral @entity227 . In typical @entity1 who adopt a significant @entity135 accompanied by a large @entity5971 , we suggest an initial combined recess-resect surgery in the intact eye. This procedure regularly led to a marked reduction of the head turn and @entity5971 . In @entity1 without significant strabismus, a full Kestenbaum procedure was successful, while @entity5971 in a @entity1 with a minor @entity135 was corrected by performing a bimedial recession.

title: Effects of extraocular muscle surgery in XXXX with @entity1939 and @entity346 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['AHP', 'anomalous head posture']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['infantile blindness']

entities_list: @entity18368 :: ('MESH:C567079', 'Disease') :: ['unilateral Ciancia syndrome']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['maldevelopment nystagmus syndrome', 'nystagmus']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: OBJECTIVE: Impairment of cell adhesion plays a vital role in @entity5 progression. E- and @entity6076 , @entity6460 , and @entity14048 are all adhesion molecules that have been implicated in the progression of several different @entity5 types. To help explain the potential role these adhesion molecules have in @entity43 , comparisons were made between expression patterns in normal ovary and various grades of primary and metastatic @entity43 . METHODS: Thirty-two primary and 8 metastatic @entity1 @entity43 and 18 samples of normal ovarian tissue were examined for adhesion molecule expression using immunohistochemistry. RESULTS: @entity14048 and @entity6460 revealed an inverse relationship between @entity5 grade and expression levels, characterized by high expression in low-grade @entity5 and low expression in high-grade @entity5 and @entity3 . @entity14048 and @entity6460 also demonstrated a shift in cellular localization from the membrane in grade 1 @entity5 to the cytoplasm in grade 3 @entity5 . @entity6076 expression showed a positive trend between expression levels and @entity5 grade. @entity5962 expression varied little between different @entity5 grades and @entity3 . Inclusion cysts (n = 6) and surface invaginations often strongly expressed @entity14048 , @entity6460 , and @entity5962 . @entity14048 expression was variable in ovarian follicles and corpora lutea depending on their stage of development. CONCLUSIONS: Although sample size is limited, these findings suggest that @entity43 is associated with down-regulation and altered cellular localization of @entity14048 and @entity6460 . In addition, variable @entity14048 expression during follicular and luteal development suggests that it has a physiological function in the ovary. Further investigation will be needed to see if it is also regulated this way during progression of @entity43 .

title: Loss of expression and altered localization of @entity14048 and XXXX protein are associated with @entity43 progression.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancers', 'progression of ovarian epithelial carcinomas', 'ovarian cancer', 'ovarian epithelial carcinomas', 'epithelial ovarian cancers']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity6460 :: (928,Gene) :: ['CD9']


abstract: BACKGROUND: Limiting the morbidity of @entity4422 requires highly specific initial treatment. In addition to a stringent surgical strategy, correct antibiotic prophylaxis seems to be associated with an improved outcome. In the current literature, the duration and type of antibiotic prophylaxis are under discussion. The aim of the study was to survey the current initial treatment regimes for @entity4422 in German emergency departments. MATERIAL AND METHODS: With an online-based anonymous 16-item questionnaire all 3006 members of the German @entity130 Society were surveyed. A total of 585 questionnaires (19.5   %) were returned completed. This article presents a descriptive analysis of the current state of treatment. RESULTS: Mainly specialists (35   %), senior physicians (30   %) and chief physicians (17   %) answered as well as interns (8   %) and out- @entity1 practitioners (10   %). Of the @entity1 65   % did not accept the classification of emergency services; however, 93   % carried out urgent or emergency surgery, 84   % started an antibiotic prophylaxis in the emergency department and 63   % used a standard operating procedure (SOP). A total of 60   % used 1 antibiotic drug, 25   % used 2 and 15   % used 3 or more substances. An antibiotic treatment for more than 3 days was performed by 60   % of @entity1 . CONCLUSION: The early initiation of antibiotic prophylaxis seems to be the standard practice in German emergency departments as well as early surgery. Strategies to improve the communication between prehospital and in-hospital teams, as well as graded antibiotic prophylaxis depending on the severity of soft tissue damage are needed.

title: [Current standard of care for initial management of XXXX in emergency departments : A nationwide survey in German @entity130 centers].

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'participants']

entities_list: @entity4422 :: ('MESH:D005597', 'Disease') :: ['open fractures']

answer: @entity4422 :: (MESH:D005597,Disease) :: ['open fractures']


abstract: BACKGROUND: GPs need accurate tools for cardiovascular (CV) risk assessment. Abnormalities in resting electrocardiograms (ECGs) relate to increased CV risk. AIM: To determine whether measurement of ECG abnormalities on top of established risk estimation (SCORE) improves CV risk classification in a primary care population. DESIGN AND SETTING: A cohort study of @entity1 enlisted with academic general practices in the Netherlands (the Utrecht Health Project [UHP]). METHOD: Incident CV events were extracted from the GP records. MEANS algorithm was used to assess ECG abnormalities. Cox proportional hazards modelling was applied to relate ECG abnormalities to CV events. For a prediction model only with SCORE variables, and a model with SCORE+ECG abnormalities, the discriminative value (area under the receiver operator curve [AUC]) and the net reclassification improvement (NRI) were estimated. RESULTS: A total of 2370 @entity1 aged 38-74 years were included, all eligible for CV risk assessment. During a mean follow-up of 7.8 years, 172 CV events occurred. In 19% of the @entity1 at least one ECG abnormality was found (Lausanne criteria). Presence of @entity955 ( @entity955 ) and @entity583 ( @entity583 ) were significantly related to CV events. The AUC of the SCORE risk factors was 0.75 (95% CI = 0.71 to 0.79). Addition of @entity583 or @entity955 resulted in an AUC of 0.76 (95% CI = 0.72 to 0.79) and 0.75 (95% CI = 0.72 to 0.79), respectively. The NRI with the addition of ECG abnormalities was small ( @entity583 1.0%; 95% CI = -3.2% to 6.9%; @entity955 0.5%; 95% CI = -3.5% to 3.3%). CONCLUSION: Performing a resting ECG in a primary care population does not seem to improve risk classification when SCORE information - age, sex, smoking, systolic blood pressure, and total @entity165 /HDL ratio - is already available.

title: Measurement of ECG abnormalities and cardiovascular risk classification: a cohort study of primary care XXXX in the Netherlands.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['AF', 'atrial fibrillation/flutter']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A prospective clinical and radiographic evaluation of 33 consecutive @entity1 with severe and @entity2003 (average Cobb angle 93 degrees, flexibility on bending films 23%) were treated with combined anterior and posterior instrumentation with a minimum follow-up of 2 years. All @entity1 underwent anterior release and VDS-Zielke Instrumentation of the primary curve. In highly rigid @entity1635 , this was preceded by a posterior release. Finally, posterior correction and fusion with a multiple hook and pedicle screw construct was performed. Thirty @entity1 were operated in one stage, three @entity1 in two stages. Preoperative curves ranged from 80 to 122 degrees Cobb angle. Frontal plane correction of the primary curve averaged 67% with an average loss of correction of 2 degrees . The apical vertebral rotation of the primary curve was corrected by 49%. In all but three @entity1 , sagittal alignment was restored. There were no @entity16 , deep wound @entity281 or @entity1516 . Combined anterior and posterior instrumentation is safe and enables an effective three-dimensional curve correction in severe and @entity2003 .

title: Combined anterior and posterior instrumentation in severe and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigid idiopathic scoliosis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1516 :: ('MESH:D011542', 'Disease') :: ['pseudarthrosis']

answer: @entity2003 :: (MESH:D009127,Disease) :: ['rigid idiopathic scoliosis']


abstract: BACKGROUND: The @entity1164 remains a major public health problem. Several studies have reported weekly variation of this dramatic event. AIM: The aim of this work is to determine the day-of-week variability in @entity1164 in northen Tunisia. METHODS: We prospectively collected clinical, socio demographic and autopsic data of victims of @entity1164 occurring in the northern Tunisia between october 1 st ,2010 and september 30,2012. RESULTS: The study population included 392 @entity1 and 108 @entity1 with a mean age of 52.27 + / - 15.8 years. Three quarters of the victims was sedentary, 57.9% were smoker and a family history of @entity944 was identified in 9.8% of cases. The vast majority of @entity204 had occurred either in a public place (41.4%) or at home (36.6%). @entity741 was the leading cause of @entity204 with 267 cases (53.4%); however a negative autopsy was found in 13.9% of victims. The highest @entity944 occurrence was on Sundays (17.8%) and the lowest on Mondays (11.4% p: 0.01).The same weekly variation was noted among both @entity1 and @entity1 , and also in victims > 60 years, a minimum of events occurred on Mondays (11.6%) and a maximum on Sundays (21.9%). In addition, we found the same peak of mortality on Sunday (18.8%) in young adults and the nadir on Monday (10.3%). CONCLUSIONS: The present study demonstrates marked variation in the occurrence of @entity1164 in the northern Tunisia with peak on Sundays and nadir on Mondays. No age or gender- related differences were found in weekly variation of @entity944 .

title: [Weekly variation of XXXX in northen Tunisia].

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['Ischemic heart disease']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity1164 :: (MESH:D016757,Disease) :: ['sudden cardiac death']


abstract: We aimed to establish a technically feasible, easily reproducible model of @entity5 . Male @entity35 received adrenal injection of @entity35 @entity1911 cells infected with the @entity526 gene for beta-galactosidase (lac Z). Each of 10 animals was perfused 7 or 24 days after @entity5 cell injection; 5 animals of each group were injected with @entity205 . Animals without @entity5 cell injection served as controls. @entity5 cells were identified and characterized in frozen sections by histochemical and immunohistochemical methods. Immunosuppressed animals had enlarged adrenals 7 days after @entity5 cell injection. In the @entity35 without immunosuppression the adrenals seemed unaltered despite microscopic demonstration of @entity5 cells. After 24 days @entity5 had developed in all animals, weighing 50 times more than normal adrenals in animals with immunosuppression, and 9 times more in animals without immunosuppression. Intraadrenal catecholaminergic @entity5 cells could be identified by beta-galactosidase expression. No animal showed systemic spread. Generation of adrenomedullary neoplasia by intraadrenal @entity1911 cell transplantation is easily reproducible and technically feasible. This model allows simultaneous study of neoplastic and normal adrenal tissues (e.g., regarding their response to drugs intended for diagnostic and therapeutic purposes). The decreased @entity5 growth in animals without immunosuppression is presumably due to the high number of intraadrenal immunocompetent cells.

title: Induction of orthotopic XXXX adrenomedullary neoplasia by intraadrenal @entity1911 cell transplantation.

entities_list: @entity1911 :: ('MESH:D010673', 'Disease') :: ['pheochromocytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'orthotopic adrenomedullary neoplasia', 'Tumor', 'tumors']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: UNASSIGNED: Therapeutic guidelines indicate @entity4770 as the first line of treatment in @entity32 and @entity455 . @entity8578 prevent formation of the platelet plug involved in primary hemostasis by inhibiting platelet activation and, combined with @entity2871 , are effective vasodilators in @entity1504 . Trans-Atlantic Inter-Society Consensus Document on Management of Peripheral Arterial Disease II guidelines indicates prostacyclins; in particular, Iloprost, as the first therapeutic option for treating @entity3657 . However, therapeutic efficacy of Iloprost has witnessed several drawbacks that have occurred in @entity1 receiving repeated weekly administration of the drug by intravenous infusions. Adverse reactions arose under perfusion with Iloprost for 6 h and @entity1 compliance was drastically decreased. Biomedical devices could provide a suitable alternative to overcome these drawbacks. In particular, elastomeric pumps, filled with Iloprost isotonic solution, could slowly release the drug, thus decreasing its side effects, representing a valid alternative to hospitalization of @entity1 affected by @entity3657 . However, the home therapy treatment of @entity1 requires long-term stability of Iloprost in solution-loaded elastomeric pumps. The aim of this work was to investigate the long-term stability of Iloprost isotonic solution in biomedical devices using Turbiscan technology. Turbiscan Lab Expert (L'Union, France) predicts the long-term stability of suspensions, emulsions and colloidal formulations by measuring backscattering and transmission of particulates dispersed in solution. The formulations were evaluated by measuring the variation of physical-chemical properties of colloids and suspensions as a function of backscattering and transmission modifications. In addition, the release profile of Iloprost isotonic solution from the biomedical device was evaluated.

title: Long Term Stability Evaluation of XXXX Released from Biomedical Device through Turbiscan Lab Expert.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral arterial disease']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['vascular damage']

entities_list: @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin']

entities_list: @entity8578 :: ('MESH:D044062', 'Chemical') :: ['Prostacyclins']

answer: @entity4770 :: (MESH:D011464,Chemical) :: ['Prostacyclin']


abstract: UNASSIGNED: The @entity1370 of @entity4447 ( @entity4448 ) limits its clinical application in @entity5 treatment. Evidences suggest that sorbus has antioxidant activity and its consumption has been linked with improved cardioprotection. In this study, we investigated the cardio-protective effect and mechanisms of Sorbus pohuashanensis (Hante) Hedl. @entity3088 (SPF) against @entity4448 in BALB/c @entity19 and H9c2 cells. Eleven major @entity3088 were confirmed by ultra-performance liquid chromatography electrospray ionization quadrupole time of flight mass spectrometry (UPLC-ESI-Q-TOF-MS). SPF recovered the @entity4448 -induced disordered electrocardiogram (ECG) and abnormal cardiac structure in the heart of @entity19 . At the same time, SPF significantly reduced levels of @entity908 kinase (CK), @entity908 kinase-MB (CK-MB) @entity880 dehydrogenase (LDH), and glutamic oxaloacetic transaminase (GOT) against @entity4448 -induced injury and inhibited @entity4448 -induced apoptosis both in vivo and in vitro. In addition, SPF regulated @entity4448 -induced oxidative stress damage by increasing the levels of @entity224 dismutase (SOD), catalase (CAT), and @entity2041 peroxidase ( @entity6172 -Px) in vivo and in vitro, and reducing reactive @entity26 species (ROS). Analysis of the oxidative stress pathways showed that SPF prevented the @entity4448 -induced downregulation of phosphorylated protein kinase B (p-Akt) in vivo and in vitro. Pre-treatment of H9c2 cells with SPF inhibited attenuation of nuclear factor ( @entity10182 ) and heme oxygenase (HO-1). Hence, SPF could be used as a preventive and therapeutic plant ingredient against @entity4448 -induced @entity1370 .

title: Effect and mechanism of Sorbus pohuashanensis (Hante) Hedl. @entity3088 protect against XXXX -induced @entity1370 .

entities_list: @entity4447 :: ('MESH:C006632', 'Chemical') :: ['arsenic trioxide']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']

answer: @entity4447 :: (MESH:C006632,Chemical) :: ['arsenic trioxide']


abstract: Immunosenescence is an age-associated dysregulation of the immune function, which contributes to increased susceptibility to disease in the elderly. Alveolar macrophages (AM) are known phagocytes that generate reactive @entity26 species (ROS) and @entity842 (NO), essential mediators for host defence. We studied phagocytosis, ROS and NO production in AM obtained from young, adult and senescent @entity35 (1-2, 9-12 and 18-24 months old, respectively) after exposure to lipopolysaccharide (LPS, 0.1-10 microg mL(-1)), @entity864 ( @entity865 , 0.1 microg mL(-1)) or LPS + @entity865 in culture. Phagocytosis was significantly lower in control AM from adult @entity35 than in AM from young animals. Nevertheless, AM from adult animals pretreated with LPS exhibited higher phagocytic capacity than AM from younger animals. ROS was identified by the NBT test at single cell level and quantified by automated image analysis. When @entity865 was added to all three populations, AM from adult and senescent animals responded more than AM from young animals. All LPS-stimulated AM produce more NO than controls. However, NO production increased three-, four- and two-fold in young, adult and senescent animals, respectively. Our results demonstrate that AM from young, adult and senescent animals display differential responsiveness to inflammatory mediators. Therefore, aging processes markedly affect AM metabolic functions and may further compromise the lung immune defence response, increasing adverse long-term health effects.

title: Age-dependent change in reactive XXXX species and @entity842 generation by @entity35 alveolar macrophages.

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity864 :: ('MESH:C554292|MESH:D013755', 'Chemical') :: ['12-O-tetradecanoylphorbol 13-acetate']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']