abstract: Thirty @entity1 with 33 @entity1317 from blunt @entity130 to the brachiocephalic branches of the aortic arch are reported. To our knowledge, this is the largest series reported to date of @entity1913 to these vessels. Mechanisms of injury included deceleration, traction, and crush. Half of the injured vessels were the innominate artery, and a quarter each were the common carotid and subclavian arteries. Common associated injuries were @entity542 , @entity2004 , @entity358 , @entity174 , and @entity130 . Widened @entity6830 and extrapleural @entity1410 were common radiographic findings, and @entity1755 was frequently suspected. Angiography was performed in all @entity1 to identify precisely the nature and site of the injury. Surgical approaches varied with the anatomical site of the injury and required consideration of vascular control in chest, neck, and upper extremity. Twenty-seven @entity1 are alive 6 months to 10 years after injury. Eighteen of 20 vascular reconstructions were patent at follow-up. No @entity1 with @entity130 had return of neurological function.

title: XXXX to the aortic arch vessels.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['long bone fractures']

entities_list: @entity1755 :: ('MESH:D001019', 'Disease') :: ['aortic rupture']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung contusion']

entities_list: @entity2004 :: ('MESH:D006468', 'Disease') :: ['hemopneumothorax']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injuries']

entities_list: @entity1913 :: ('MESH:D014949', 'Disease') :: ['blunt injuries']

entities_list: @entity6830 :: ('MESH:D008479', 'Disease') :: ['mediastinum']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['brachioplexus injury', 'brachioplexus injuries', 'trauma']

answer: @entity1913 :: (MESH:D014949,Disease) :: ['Blunt injuries']


abstract: BACKGROUND: @entity1600 ( @entity1600 ) status is one of the strongest prognostic factors after @entity1086 ( @entity1086 ) resection. The adequate extension of @entity1600 dissection and the stratification of the prognosis in N+ @entity1 have been debated. The present study aims to clarify these issues. METHODS: A total of 112 consecutive @entity1 who underwent operations for @entity1086 with @entity1600 dissection were analyzed. Twenty-five @entity1 (22.3  %) had D1 dissection (hepatic pedicle), and 87 (77.7  %) had D2 dissection (hepatic pedicle, celiac and retro-pancreatic area). The @entity1600 ratio (LNR) was computed as follows: number of metastatic LNs/number of retrieved LNs. RESULTS: The median number of retrieved LNs was 7 (1-35). Fifty-nine @entity1 (52.7  %) had @entity1600 metastases (22 N2). D2 dissection allowed the retrieval of more LNs (8 vs. 3, p  =  0.0007), with similar short-term outcomes. Common bile duct (CBD) resection (n  =  41) did not increase the number of retrieved LNs. In five @entity1 , D2 dissection identified skip @entity1600 metastases that otherwise would have been missed. @entity1600 metastases negatively impacted survival (5-years survival 57.2  % if N0 vs. 12.4  % if N+, p  <  0.0001), but N1 and N2 @entity1 had similar survival rates. The number of @entity1600 + (1-3 vs. >= 4) did not impact prognosis. An LNR  =  0.15 stratified the prognosis of N+ @entity1 : 5-years survival 32.7  % if LNR   <=  0.15 vs. 10.3  % if LNR  >  0.15 (multivariate analysis p  =  0.007). CONCLUSIONS: A D2 @entity1600 dissection is recommended in all @entity1 , because it allows for better staging. CBD resection does not improve @entity1600 dissection. An LNR  =  0.15, not the site of metastatic LNs, stratified the prognoses of N+ @entity1 .

title: Lymph Node Metastases in @entity1 Undergoing Surgery for a XXXX . Extension of the Lymph Node Dissection and Prognostic Value of the Lymph Node Ratio.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder cancer', 'GBC']

answer: @entity1086 :: (MESH:D005706,Disease) :: ['Gallbladder Cancer']


abstract: PURPOSE: To determine whether a bacteriophage antimicrobial-lock technique can reduce bacterial colonization and biofilm formation on indwelling central venous catheters in a @entity95 model. MATERIALS AND METHODS: Cuffed central venous catheters were inserted into the jugular vein of female New Zealand White @entity95 under image guidance. Catheters were inoculated for 24 hours with broth culture of @entity3256 -sensitive @entity794 . The inoculum was aspirated, and @entity95 were randomly assigned to two equal groups for 24 hours: (i) untreated controls (heparinized saline lock), (ii) bacteriophage antimicrobial-lock (staphylococcal @entity13794 , propagated titer > 10(8)/mL). Blood cultures were obtained via peripheral veins, and the catheters were removed for quantitative culture and scanning electron microscopy. RESULTS: Mean colony-forming units (CFU) per cm(2) of the distal catheter segment, as a measure of biofilm, were significantly decreased in experimental animals compared with controls (control, 1.2   10(5) CFU/cm(2); experimental, 7.6   10(3); P = .016). Scanning electron microscopy demonstrated that biofilms were present on the surface of five of five control catheters but only one of five treated catheters (P = .048). Blood culture results were not significantly different between the groups. CONCLUSIONS: In a @entity95 model, treatment of infected central venous catheters with a bacteriophage antimicrobial-lock technique significantly reduced bacterial colonization and biofilm presence. Our data represent a preliminary step toward use of bacteriophage therapy for prevention and treatment of central @entity1212 .

title: Bacteriophage K antimicrobial-lock technique for treatment of XXXX central @entity1212 : a leporine model efficacy analysis.

entities_list: @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin']

entities_list: @entity1212 :: ('MESH:D055499', 'Disease') :: ['venous catheter-associated infection']

entities_list: @entity13794 :: ('221915', 'Species') :: ['bacteriophage K']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

answer: @entity794 :: (1280,Species) :: ['Staphylococcus aureus']


abstract: OBJECTIVE: To determine whether compression ultrasound examination of both legs, to detect @entity1150 , can be the examination of first choice in @entity1 clinically suspected of @entity1151 , assuming that the therapy of @entity715 is the same as the therapy of @entity887 . DESIGN: Prospective study. SETTING: St. Clara Hospital, Rotterdam, the Netherlands. METHODS: 337 consecutive @entity1 (157 @entity1 and 180 @entity1 , mean age 65 years, SD: 17.4) suspected of @entity1151 underwent compression ultrasound examination of the femoral and popliteal veins to detect @entity1150 , and perfusion lung scintigraphy, with ventilation scintigraphy if indicated. Ultrasound examinations and lung scans were interpreted independently and blinded. A financial analysis of the various strategies was made. RESULTS: @entity1150 was demonstrated ultrasonographically in four (2%) of 208 @entity1 with a normal lung scan, in four (9%) of 43 @entity1 with a non-diagnostic lung scan, and in 30 (35%) of 86 @entity1 with a high probability lung scan. By starting the diagnostic investigation with ultrasound examination 38 lung scans and chest X-rays would be saved at the cost of 294 extra ultrasound examinations. Because ultrasound examinations are relatively inexpensive a cost reduction of 3.4% would be realised, for the Netherlands approximately 1.4 million guilders. In the United States, however, costs would increase because of the high prices of ultrasound examinations. CONCLUSION: Compression ultrasound examination of both legs can be the examination of first choice in the Netherlands in @entity1 suspected of @entity1151 , as it is cost effective.

title: [Ultrasonography of the leg veins is cost-effective and can be the preferred diagnostic study in suspected XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis', 'Deep venous thrombosis']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1151 :: (MESH:D011655,Disease) :: ['pulmonary embolism']


abstract: STUDY DESIGN: Cross-sectional national survey. OBJECTIVES: To explore the association between fatigue and community participation frequency and provide an adjusted model of the relationship including important covariates. SETTING: Canada; Community. METHODS: Data were obtained from the @entity21191 Hansen Spinal Cord Injury Registry Community Survey. We used multi-variable regression analyses with hierarchical backward elimination, including variable specification, interaction assessment and confounding assessment. Variables with statistically significant correlation with the primary-dependent variable (participation) were included for modeling. RESULTS: The crude model of association between @entity1295 accounted for 7.2% of the variance in participation scores. The full model with all a priori selected variables accounted for 25.1% of variance in participation scores. The adjusted model, including the identified confounders ( @entity158 , @entity308 mood, comorbidities and level of injury), accounted for 21.1% of variance in participation scores. Depressive mood variables had the highest standardized beta coefficients, reflecting the largest contribution to this model. CONCLUSION: Fatigue has a statistically significant negative association with participation for individuals with @entity1566 , when controlling for @entity158 , @entity308 mood, comorbidities and level of injury. Multifaceted clinical interventions and research addressing fatigue, @entity158 and @entity308 symptoms are warranted.Spinal Cord advance online publication, 15 September 2015; doi:10.1038/sc.2015.149.

title: The relationship between @entity1295 in XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

entities_list: @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue and participation']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: Based upon currently available evidence, a practical dietary prescription should be: For the overweight, @entity353 should be the primary goal. For all @entity101 , dietary @entity1372 should be restricted to a 2 g (88 mmol/d) level. @entity972 intake need not be specifically increased since it will rise with a lowered @entity1372 intake. Those who are @entity8598 may benefit from @entity972 supplementation. Supplemental @entity1760 and @entity460 should only be given to those who are deficient, until additional evidence of their efficacy is available. Caution is advised in not reducing the dietary sources of @entity460 when dietary @entity1372 is reduced. More fiber and less saturated fat are beneficial for other reasons and may also help to lower the blood pressure. @entity167 should be limited to two ounces per day. The 1984 report of the Joint National Committee (23) recommends that "nonpharmacologic approaches [be] used both as definitive intervention and as an adjunct to drug therapy." In addressing the 40% of all @entity101 who are in the 90 to 94 mmHg range, the report states, "Nonpharmacologic therapy should be pursued aggressively while blood pressures are carefully monitored." Dietary changes are the major components of nondrug therapy. They should be enthusiastically offered to all @entity101 , while providing the various motivational tools and follow-up procedures that are readily available to maximize their acceptance and effectiveness.

title: Dietary aspects of the treatment of XXXX .

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['Potassium', 'potassium']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight reduction']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity8598 :: ('MESH:D020514', 'Disease') :: ['hypokalemic']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: OBJECTIVE: To investigate whether @entity526 @entity793 is associated with the development of @entity101 during a long-term follow-up. METHODS: A prospective cohort study was performed among the @entity1 of two population-based studies. Between 1974 and 1986 all @entity1 aged 39 to 68 years old, who lived in Utrecht, the Netherlands, were invited to participate in a @entity0 screening program. The @entity1 completed a questionnaire, underwent a medical examination, and collected a morning urine sample that remained stored. From 1993 to 1997 another population-based study was performed. We performed a full cohort analysis for 444 @entity1 who participated in both studies. @entity526 @entity793 was diagnosed by a real-time PCR. @entity101 was defined as the use of antihypertensive medication and/or a measured systolic blood pressure of at least 160 mmHg or a diastolic blood pressure of 95 mmHg or higher. The mean follow-up was 11.5+/-1.7 years. RESULTS: Forty @entity1 (9%) had @entity526 @entity793 at baseline. @entity1 who had @entity793 at baseline had a mean blood pressure at study endpoint of 133+/-20 mmHg systolic and 78+/-11 mmHg diastolic, and @entity1 without @entity793 had values of 129+/-20 and 78+/-11 mmHg, respectively (p-values for difference 0.33 and 0.88). Although @entity526 @entity793 was not associated with the blood pressure as a continuous variable, it was associated with the development of @entity101 during follow-up (OR 2.8, 95% CI 1.4-5.5). CONCLUSION: @entity526 @entity793 may increase the risk of future @entity101 .

title: @entity526 XXXX in female adults is associated with the development of @entity101 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

entities_list: @entity793 :: ('MESH:D001437', 'Disease') :: ['bacteriuria']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity793 :: (MESH:D001437,Disease) :: ['bacteriuria']


abstract: Fifty-seven @entity1 in initial phase of @entity2799 ( @entity2799 ) were treated in the same department with heparin infusion, platelet transfusions, and two related induction regimens both including @entity2592 and @entity5699 . Clinical and biological findings at presentation were studied. The complete remission (CR) rate was 53%. Twenty-seven @entity1 (47%) died during the initial course of the disease, either before day 5 ( @entity204 [ @entity204 ], n = 7) or after day 5 ( @entity204 in aplasia [DA], n = 20). Most @entity204 was due to @entity1779 (6/7), especially when large @entity548 had been seen on fundus oculi examination. Most DA was due to multivisceral failure (9/20). No correlation was found between initial disseminated @entity5642 (DIC) and @entity204 . However, the worsening of coagulation parameters during induction therapy, with or without initial @entity2699 , significantly increased the occurrence of @entity177 which were particularly frequent during the first month. The median duration of survival was short (3.5 months) and the median duration of CR (11 months) was similar to that of other @entity3052 treated with the same regimens. The possible causes of the high mortality observed during the initial courses of @entity2799 and the possible benefit of a more graduate induction chemotherapy are discussed.

title: XXXX in 57 previously untreated @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2799 :: ('MESH:D015473', 'Disease') :: ['APL', 'acute promyelocytic leukemia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages']

entities_list: @entity5699 :: ('MESH:D003630', 'Chemical') :: ['daunorubicin']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytosine arabinoside']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal and respiratory failure']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemias']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['ED', 'early death', 'death']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage']

answer: @entity2799 :: (MESH:D015473,Disease) :: ['Acute promyelocytic leukemia']


abstract: Increasing the @entity7461 (LNA; 18:3 cis-9,cis-12,cis-15) content of @entity6155 fat might help promote consumers' health. The objective of this study was to determine the potential to alter the content of LNA in @entity6155 by duodenal infusion of a free @entity844 mixture rich in LNA. Four multiparous lactating Chinese Holstein @entity291 fitted with duodenal cannulas were administered 2 treatments in a crossover design: an LNA-rich @entity844 infusion at varying concentrations (0, 40, 80, 120, and 160 g/d) versus a basal infusate control. Dry matter intake was not affected by LNA infusions. @entity6155 production tended to decrease and was quadratically affected as LNA infusion increased, but 4% fat-corrected @entity6155 yield was not changed. @entity6155 fat content tended to increase linearly with LNA infusion. @entity6155 protein content was not changed by LNA infusion, whereas @entity6155 lactose content and yield were decreased quadratically as LNA infusion increased. Increasing the amount of LNA infused into the duodenum linearly increased concentrations of 18:3 cis-9,cis-12,cis-15 (0.61 to 25.4 g/100g of total @entity1718 ) and 18:2 cis-9,cis-12 in @entity6155 fat. Increasing LNA decreased the percentages of 4:0, 14:0, and 16:0 @entity1718 linearly. Increasing LNA also linearly decreased the percentages of 18:1 cis-9 and 18:2 cis-9,trans-11 in @entity6155 fat. @entity6155 fat content of 20:5 cis-5,cis-8,cis-11,cis-14,cis-17 was quadratically affected, whereas concentrations of 18:0, 18:1 trans-9, 18:1 trans-11, and 18:2 trans-10,cis-12 were not affected. Increasing the supply of 18:3 cis-9,cis-12,cis-15 to the small intestine linearly increased 18:3 cis-9,cis-12,cis-15 in @entity6155 fat and markedly altered @entity6155 fat composition.

title: Short communication: responses to increasing amounts of free XXXX infused into the duodenum of lactating dairy @entity291 .

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity7461 :: ('MESH:D017962', 'Chemical') :: ['alpha-linolenic acid']

answer: @entity7461 :: (MESH:D017962,Chemical) :: ['alpha-linolenic acid']


abstract: We investigated the induction of @entity7222 decarboxylase during liver regeneration after partial hepatectomy in @entity3241 -deficient @entity19 . There were no significant differences in @entity12154 activity or the time course of changes in @entity12154 activity between @entity3241 -deficient @entity19 and wild-type @entity19 . PI 3'-kinase activity showed similar increases in both groups of @entity19 . Furthermore, @entity12154 induction in @entity3241 transfected CHO cells was studied after stimulation by addition of FCS. The maximal @entity12154 activity was 2.5-fold greater in @entity3241 -transfected CHO cells than in control CHO cells. Our results suggest that the @entity3241 pathway may be involved in @entity12154 induction. The absence of a difference in @entity12154 and PI 3'-kinase activity in the regenerating liver between @entity3241 -deficient @entity19 and wild-type @entity19 may have been related to the compensatory effects of @entity3238 /pp190 [Araki et al. Nature (1994) 372, 186-190; Tobe et al. J.Biol.Chem. (1995) 270, 5698-5701].

title: @entity7222 decarboxylase induction during liver regeneration in XXXX -deficient @entity19 .

entities_list: @entity7222 :: ('CHEBI:18257', 'Chemical') :: ['ornithine']

answer: @entity3241 :: (16367(Tax:10090),Gene) :: ['IRS-1']


abstract: BACKGROUND: We have previously investigated the microlocalisation of M1 and M2 macrophages in NSCLC. This study investigated the non-macrophage (NM) expression of proteins associated with M1 and M2 macrophages in NSCLC. METHODS: Using immunohistochemistry, @entity469 (+) macrophages and proteins associated with either a cytotoxic M1 phenotype (HLA-DR, iNOS, and @entity11771 , or a non-cytotoxic M2 phenotype ( @entity11772 and @entity7 ) were identified. NM expression of the markers was analysed in the islets and stroma of surgically resected @entity5 from 20 @entity1 with @entity1349 ( @entity1349 ) (median 92.7 months) and 20 @entity1 with @entity1349 ( @entity1349 ) (median 7.7 months). RESULTS: The NM expression of NM-HLA-DR (p<0.001), NM-iNOS (p=0.02) and NM- @entity11773 /14 (p=0.02) was increased in @entity1349 compared to @entity1349 @entity1 in the @entity5 islets. The @entity5 islet expression of NM- @entity7 , was decreased in @entity1349 compared to @entity1349 @entity1 (p<0.001). There was more NM- @entity11772 expression (p=0.04) but less NM-iNOS (p=0.002) and @entity11771 (p=0.01) expression in the stroma of @entity1349 @entity1 compared with @entity1349 @entity1 . The 5-year survival for @entity1 with above and below median NM expression of the markers in the islets was 74.9% versus 4.7% (NM-HLA-DR p<0.001), 65.0% versus 14.6% (NM-iNOS p=0.003), and 54.3% versus 22.2% (NM- @entity11773 /14 p=0.04), as opposed to 34.1% versus 44.4% (NM- @entity11772 p=0.41) and 19.4% versus 59.0% (NM- @entity7 p=0.001). CONCLUSIONS: Cell proteins associated with M1 and M2 macrophages are also expressed by other cell types in the @entity5 islets and stroma of @entity1 with NSCLC. Their tissue and cellular microlocalisation is associated with important differences in clinical outcome.

title: The tissue microlocalisation and cellular expression of @entity11772 , @entity7 , HLA-DR, iNOS, and XXXX /14 is correlated to clinical outcome in NSCLC.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['PS', 'ES', 'poor survival', 'extended survival']

answer: @entity11773 :: (6833,Gene) :: ['MRP 8']


abstract: OBJECTIVES: The purpose of this study was to compare the safety and efficacy of @entity117 ( @entity1281 ) and @entity1229 for thromboprophylaxis after the Fontan procedure. BACKGROUND: Fontan surgery is the definitive palliation for @entity1 with single-ventricle physiology. @entity715 is an important complication; the optimal thromboprophylaxis strategy has not been determined. METHODS: We performed a multicenter international randomized trial of primary prophylactic anticoagulation after Fontan surgery. @entity1 were randomized to receive for 2 years either ASA (5 mg/kg/day, no heparin phase) or @entity1229 (started within 24 h of heparin lead-in; target international normalized ratio: 2.0 to 3.0). Primary endpoint (intention to treat) was @entity715 , @entity887 (all events adjudicated). At 3 months and 2 years after the Fontan procedure, transthoracic and transesophageal echocardiograms were obtained as routine surveillance. @entity548 and @entity204 were primary adverse outcomes. RESULTS: A total of 111 eligible @entity1 were randomized (57 to ASA, 54 to heparin/ @entity1229 ). Baseline characteristics for each group were similar. There were 2 deaths unrelated to @entity715 or @entity548 . There were 13 @entity715 in the heparin/ @entity1229 group (3 clinical, 10 routine echo) and 12 @entity715 in the ASA group (4 clinical, 8 routine echo). Overall freedom from @entity715 2 years after Fontan surgery was 19%, despite @entity715 prophylaxis. Cumulative risk of @entity715 was persistent but varying and similar for both groups (p = 0.45). @entity548 occurred in 1 @entity1 in each group. CONCLUSIONS: There was no significant difference between ASA and heparin/ @entity1229 as primary thromboprophylaxis in the first 2 years after Fontan surgery. The @entity715 rate was suboptimal for both regimens, suggesting alternative approaches should be considered. (International Multi Centre Randomized Clinical Trial Of Anticoagulation In @entity1 Following Fontan Procedures; NCT00182104).

title: A multicenter, randomized trial comparing heparin/ XXXX and @entity117 as primary thromboprophylaxis for 2 years after the Fontan procedure in @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'Children', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Major bleeding', 'bleeding']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['intracardiac or embolic']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombosis', 'Thrombosis']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

answer: @entity1229 :: (MESH:D014859,Chemical) :: ['warfarin']


abstract: A @entity1 cell clone (SF-16) displaying strong cytolytic activity against fresh @entity5 target cells was used for production of @entity19 mAbs against surface antigens expressed by @entity1199 -activated killer (LAK) cells and their peripheral blood precursors. The preliminary screening of hybridoma supernatants was performed according to the ability to bind SF-16 cells. Selected mAbs were further analyzed for their reactivity with several T and B cell lines and with peripheral blood T and non-T cell populations. A selected mAb, termed anti- @entity8720 , only reacted with some T cell lines and with 15-30% of PBMC. Approximately 10-15% E-rosetting (T) cells and 40-50% E-rosette-negative cells were @entity8720 , as determined by cytofluorometric analysis. As the fluorescence distribution of @entity8720 antigen was clearly bimodal, @entity8720 + and @entity8720 - cells could be separated by FACS. Positive cells were composed of large granular lymphocytes (LGL), whereas negative cells were mostly small lymphocytes and monocytes without LGL. After culture in @entity5041 , purified @entity8720 (but not @entity8720 -) cells acquired the ability to lyse NK-resistant fresh @entity320 target cells. In addition, only the @entity8720 + fraction of PBMC cultured for 5 d in @entity5041 lysed fresh @entity5 targets, thus indicating that the @entity8720 antigen is expressed also on LAK effector cells. Unlike some other LGL/NK cell markers, @entity8720 antigen is characterized by a stable expression: thus, @entity8720 + cell populations cultured for up to 20 d in @entity5041 maintained the @entity8720 antigen expression, whereas @entity4755 and, partially, @entity4071 were lost. Finally the cytolytic activity of LAK effector cells generated from PBMC cultured for 3 d in @entity5041 was susceptible to inhibition by the anti- @entity8720 mAb.

title: A novel 120-kD surface antigen expressed by a subset of XXXX lymphocytes. Evidence that @entity1199 -activated killer cells express this molecule and use it in their effector function.

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Between 1974 and 1981, 27 @entity1 became pregnant after prosthetic heart valve replacement with a total of 45 pregnancies. Four pregnancies terminated in therapeutic abortions. Of the remaining 41 pregnancies, 30 were associated with the use of anticoagulants and 11 not. @entity548 related to anticoagulant therapy occurred in one @entity1 . The foetal loss in the group with anticoagulant therapy was 33 per cent (10 abortions) and that in the group without was 9 per cent (one abortion). The use of @entity117 and dipyridamole during pregnancy (eight pregnancies) did not appear to threaten the outcome of pregnancy. A total of 30 babies were born alive and 20 per cent of them were light for date. There was no perinatal mortality. The typical warfarin @entity2241 was not found. @entity154 in four newborns included @entity1276 , harelip and @entity2419 , bilateral accessory auricles and bilateral incurving 5th fingers. Subsequently, all except the newborn with @entity1276 showed normal developmental milestones.

title: Pregnancy in XXXX with prosthetic heart valves: an experience with 45 pregnancies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['Congenital anomalies']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Haemorrhage']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['congenital hydrocephalus']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['complete cleft palate']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['embryopathy']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND OBJECTIVES: The @entity25079 (Simplified Acute Physiology Score 3) prognostic system is composed of 20 parameters, represented by an acute physiology score and assessment of the previous status, aimed at establishing a predictive mortality index for @entity1 admitted to intensive care units (ICU). The objective of this study was to validate this system and determine its discriminatory power in surgical @entity1 in Brazil. METHODS: This is a prospective study undertaken in two surgical ICUs of two different hospitals over a one-year period; @entity1 younger than 16 years, who stay at the ICU for less than 24 hours, readmitted to the unit, and those admitted for dialysis were excluded from the study. The predictive ability of the @entity25079 index to differentiate survivors and non-survivors was determined by the ROC curve and calibration by the Hosmer-Lemeshow goodness-of-fit test. RESULTS: One thousand three-hundred and ten @entity1 were included in the study. Gastrointestinal surgeries predominated (34.9%). Eighteen was the lower @entity25079 index and the highest was 154, with a mean of 48.5 +/- 18.1. The predicted and real hospital mortality was 10.3% and 10.8%, respectively; the standardized mortality ratio (SMR) was 1.04 (95%CI = 1.03-1.07). Calibration by the Hosmer and Lemeshow method showed X(2) = 10.47 p = 0.234. The @entity25079 score that better discriminated survivors and non-survivors was 57, with sensitivity of 75.8% and specificity 86%. Among the @entity1 with @entity25079 index higher than 57, 73.5% did not survive versus 26.5% who survived (OR= 1.32, 95%CI 1.23-1.42, p < 0.0001). CONCLUSIONS: The @entity25079 system is valid for the Brazilian population of surgical @entity1 , being a useful indicator of critical @entity1 and to determine greater care in this group.

title: Applicability of the simplified acute physiology score ( XXXX ) in Brazilian hospitals.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity25079 :: (55291,Gene) :: ['SAPS 3']


abstract: Several rapid extraction methods were evaluated for use with a monoclonal antibody-based competitive inhibition ELISA (cELISA) to detect @entity2831 ( @entity2832 ) in @entity1573 liver tissue. These methods included extraction of the samples with (1) aqueous buffer with or without ultrafiltration, (2) @entity1626 /water, (3) @entity1042 /water, or (4) @entity1324 . The organic extraction methods were evaluated with or without solvent evaporation prior to dilution into assay buffer for the cELISA. The aqueous-based extraction methods were compatible with the cELISA. However, of the organic extraction methods, only the @entity1324 liver extract with solvent evaporation prior to analysis was compatible with the cELISA. The cELISA method coupled to aqueous- or @entity1324 -based sample extraction as well as an HPLC method was evaluated for the analysis of @entity1573 liver tissues fortified with @entity2832 at levels from 0.2 to 0.025 ppm. Mean @entity2832 recoveries for the HPLC method and for the cELISA method using samples prepared by aqueous extraction, aqueous extraction and ultrafiltration, or @entity1324 extraction, evaporation, and reconstitution were 68.9, 95.7, 60.1, and 52.5%, respectively. For the analysis of samples obtained from an @entity2832 incurred residue study, HPLC and cELISA analysis of the same organic extract gave results that were highly correlated (R(2) = 0.976; p < 0.0001). However, results obtained from the analysis of aqueous extracts by cELISA did not correlate well with those obtained by HPLC (R(2) = 0.61, p > 0. 0006). This was attributed to the coextraction of cross-reactive @entity2832 -related residues that were not quantified by the HPLC method. The presence of these residues should be considered during data interpretation when ELISA methods coupled with rapid aqueous extraction of samples are used in @entity2832 residue monitoring programs.

title: Development of a monoclonal antibody-based cELISA for the analysis of XXXX . 2. Evaluation of rapid extraction methods and implications for the analysis of incurred residues in @entity1573 liver tissue.

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile']

entities_list: @entity2831 :: ('MESH:D013412', 'Chemical') :: ['sulfadimethoxine']

answer: @entity2831 :: (MESH:D013412,Chemical) :: ['sulfadimethoxine']


abstract: Differentiation of trophoblast giant cells is an early event during the process of @entity19 embryo implantation. However, differentiation of secondary trophoblast giant cells in the rodent is still only partially understood, probably because of the lack of suitable in vitro models and cell markers. In order to advance our understanding of trophoblast differentiation, suitable in vitro models and markers are required to study their development. The objectives of this study were to establish and characterise a serum-free in vitro model for @entity19 secondary trophoblast cells. Secondary trophoblast giant cells growing in vitro and paraffin sections of day 8.5 postcoitum @entity19 embryos were processed for immunostaining to establish the expression of potential markers using antibodies to blood group antigens, E-cadherin, alpha(7) integrins and activator protein-gamma, as well as @entity17164 . Within 3 days in serum-free culture, ectoplacental cone-derived secondary trophoblast cells underwent simultaneous induction of both morphological and functional differentiation. Secondary trophoblasts grew in vitro as a monolayer of cells with giant nuclei and expressed B and Le-b/Le-y blood group antigens, alpha(7) integrins and @entity17164 , as well as activator protein-gamma. Transcripts for activator protein-gamma and @entity17164 were detected in cultures by RT-PCR and for @entity17164 by in situ hybridisation. At later time-points apoptosis increased. A fibronectin substrate significantly increased secondary trophoblast cell numbers and surface area of outgrowth. The increase in cells with giant nuclei coincided with induction of @entity17164 expression. A relationship was found between the nuclear area of secondary trophoblast cells and expression of @entity17164 .

title: Trophoblast differentiation in vitro: establishment and characterisation of a serum-free culture model for XXXX secondary trophoblast giant cells.

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: UNASSIGNED: 209 Background: Rolapitant, a novel @entity9766 antagonist, showed efficacy in CINV prevention in @entity1 (pts) receiving @entity34 ( @entity5948 / @entity786 (AC) and other regimens) in a global phase 3 trial. Recent anti-emetic guidelines consider AC based regimens to be highly emetogenic. In this post hoc analysis, the efficacy and safety of rolapitant was assessed in Cycle 1 in pts receiving non-AC @entity34 , and in the subset of pts receiving @entity3003 -based @entity34 . METHODS: In a double-blind, active-controlled study, pts were randomized to oral @entity17939 180 mg or placebo 1-2 hours before @entity34 . All pts received @entity10442 2 mg oral on days 1-3 and oral @entity619 20 mg on day 1. Complete response (CR = no emesis + no use of rescue medication), no emesis, and no @entity390 were assessed in overall (0-120 h), acute (0-24 h), and delayed ( > 24-120 h) phases. RESULTS: CR was significantly (P < 0.01) higher with rolapitant than active control in overall and delayed phases in the @entity3003 subset and in all 3 phases in the non-AC population (Table). No emesis rates were significantly (p < 0.05) higher with rolapitant in the @entity3003 subset in the overall phase. No @entity390 rates were significantly (P < 0.05) higher with rolapitant in the overall and delayed phases in @entity3003 -based @entity34 . Incidences of treatment-related AEs in Cycle 1 with rolapitant vs. active control were 11.3% vs. 6.7% in the @entity3003 -based subset. Most common AEs with rolapitant and active control were @entity1142 , fatigue, and @entity10 . CONCLUSIONS: Rolapitant was superior to active control in preventing CINV in pts receiving non-AC @entity34 , including in the subgroup receiving @entity3003 . @entity17939 was well tolerated with low incidence of AEs. CLINICAL TRIAL INFORMATION: NCT01500226. [Table: see text].

title: Efficacy and safety of rolapitant for prevention of chemotherapy-induced nausea and vomiting (CINV) in non- @entity5948 / @entity786 (AC)-based XXXX ( @entity34 ).

entities_list: @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity10442 :: ('MESH:D017829', 'Chemical') :: ['granisetron']

entities_list: @entity17939 :: ('MESH:C578834', 'Chemical') :: ['Rolapitant', 'rolapitant']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

answer: @entity34 :: (MESH:D016609,Disease) :: ['moderately emetogenic therapy']


abstract: @entity362 and @entity17538 are the most common @entity5 and are very well encapsulated. They are very slow growing and have the potential for recurrence if incompletely excised and a very remote chance for malignant changes. These can be freed from surrounding tissue without difficulty, but because of the fibrous nature of the capsule, its violation is more likely with suction technique and may result in an inadequate resection, possibly leading to recurrence. Furthermore, liposuction alone will not allow histopathological study of the swellings. Therefore, we report here the treatment of moderate (>4-10 cm) and large (>10 cm) @entity362 with liposuction-assisted surgical extraction of the capsule via the same wound (1 cm in length). This capsule extraction is aimed at avoiding recurrence and evaluating the histopathological nature of these swellings. 16 @entity1 (nine @entity1 and seven @entity1 ) presented with @entity362 (in 11 @entity1 ) and @entity362 (in five @entity1 ) have been successfully treated. Methods involved 1-cm incision for both liposuction and surgical removal of the capsule. Another 1-cm counter-incision may be needed in case of large size @entity362 . High @entity1 satisfaction was achieved because of the good cosmetic results due to the small postoperative residual scar and the smooth postoperative course. There has been no recorded recurrence in six years postoperative followup.

title: The use of suction-assisted surgical extraction of moderate and large XXXX : long-term follow-up.

entities_list: @entity362 :: ('MESH:D008067', 'Disease') :: ['multiple lipomas', 'solitary lipomas', 'lipomas', 'Solitary lipomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients', 'patient']

entities_list: @entity17538 :: ('OMIM:151900', 'Disease') :: ['familial multiple lipomatosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['benign tumors']

answer: @entity362 :: (MESH:D008067,Disease) :: ['lipomas']


abstract: Holzman @entity35 and C3H/Anf @entity19 were infected with the Tulahu  n strain of @entity1527 . Infected @entity35 had a 16% cumulative mortality during a 49-day observation period. The @entity5895 increased to a peak on the 21st day, and then decreased abruptly. In the inoculated @entity19 , maximum numbers of parasites were detected after 15 days and an 87% cumulative mortality was observed during the @entity281 . Three serological techniques using antigens of the metacyclic stages of @entity1527 were employed to compare the levels of humoral antibodies during the early phase of @entity281 . These included: the direct agglutination test (DAT), the indirect immunofluorescent antibody test (IFAT), the enzyme-linked immunosorbent assay (ELISA) which detected IgG (ELISA-IgG) and the ELISA which detected IgM (ELISA-IgM). Antibody titers were first found in antisera from @entity35 after 7 days by the DAT and the ELISA-IgM and after 14 days by the IFAT and the ELISA-IgG. Peak titers were measured on day 21 by the ELISA-IgM. The DAT, the IFAT, and the ELISA-IgG titers increased through 49 days. Antisera collected from @entity19 first reacted with T. cruzi antigens on day 10 in the DAT, the ELISA-IgG, and the ELISA-IgM, and on day 15 in the IFAT. Peak titers were recorded on day 20 with the DAT and the ELISA-IgM. The IFAT and the ELISA-IgG titers continued to rise through 30 days. Alterations in production of antibodies during @entity281 may in part reflect responses to different parasite antigens. The variations in titers of the antisera from infected rodents indicated that metacyclic trypomastigotes share antigens with other stages of the parasite. These metacyclic stage antigens showed a potential for use as serodiagnostic reagents.

title: Humoral immune responses to metacyclic stages of @entity1527 in experimentally infected XXXX and @entity19 .

entities_list: @entity1527 :: ('5693', 'Species') :: ['Trypanosoma cruzi', 'T. cruzi']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemias']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: @entity302 typically reveal a high degree of stereotypy, that is, for an individual @entity1 they are characterized by an ordered and predictable sequence of symptoms and signs with @entity306 variability. Stereotypy implies that ictal neuronal dynamics might have deterministic characteristics, presumably most pronounced in the ictogenic parts of the brain, which may provide diagnostically and therapeutically important information. Therefore the goal of our study was to search for indications of determinism in periictal intracranial electroencephalography (EEG) studies recorded from @entity1 with pharmacoresistent @entity302 . METHODS: We assessed the number of forbidden ordinal patterns of 110 periictal multichannel intracranial EEG studies of 16 @entity1 . Ordinal patterns are derived from the rank order of short sequences of consecutive EEG values. Ordinal patterns are well suited for analyzing real-world time series, for they have low sensitivity for many forms of noise and are applicable to nonstationary data. Although Gaussian random dynamics generate all possible ordinal patterns for a given sequence length, deterministic dynamics typically manifest with less random and more regular signals that miss a certain number of all the possible ordinal patterns. These missing ordinal patterns are referred to as "forbidden ordinal patterns." In this study, the number of forbidden ordinal patterns n(fp) of an EEG signal was interpreted as an indication of determinism, when it was larger than the number of forbidden patterns occurring in amplitude adjusted Fourier transform surrogates. We computed n(fp) for each EEG signal in a time-resolved way by using a moving-window approach. Then we specifically investigated n(mean)(fp) denoting the average number of forbidden patterns across all EEG signals, and n(max)(fp), which represents the number of forbidden patterns occurring in the EEG signal with the largest n(fp) during the @entity410 -onset period. KEY FINDINGS: The average number of forbidden patterns of all EEG signals, n(mean)(fp), typically first increased and then decreased during the @entity410 . However, these changes were not statistically significant relative to the preseizure time period. In contrast, n(max)(fp)typically increased significantly during the first third of the @entity410 period and then gradually decreased toward and beyond @entity410 termination. In those @entity1 who became @entity410 free following surgery, a larger percentage of the EEG signals containing the maximal number of forbidden patterns during the @entity410 -onset period tended to be recorded from within the visually identified @entity410 -onset zones. SIGNIFICANCE: Our findings demonstrate a spatiotemporally limited shift of neuronal dynamics toward a more deterministic dynamic regimen, specifically pronounced during the @entity410 -onset period. Assessing the number of forbidden ordinal patterns of intracranial EEG provides quantitative and observer-independent information. We propose that it is at least partially complementary to classical visual EEG reading and may be diagnostically helpful to better delineate ictogenic parts of the brain.

title: Forbidden ordinal patterns of periictal intracranial EEG indicate deterministic dynamics in @entity1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Epileptic seizures', 'epilepsy']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['typically little']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic seizures']


abstract: There is little data on suicide among elderly @entity308 @entity1 seeking @entity146 help. Recent studies have demonstrated that @entity221 may increase this risk. We aimed to assess, retrospectively, the association between suicide and @entity221 among @entity308 elderly @entity146 @entity1 . All medical records of @entity1 admitted during a 10-year period to an acute @entity146 ward, after having attempted suicide, were reviewed. Inclusion criteria were: age>65 years, diagnosis of a @entity308 and intact cognition. The comparison group consisted of previous or subsequent admissions, closest (by date), of elderly @entity1 , matching the inclusion criteria, but without previous record of attempting suicide, into the same ward. The cumulative illness rating scale (CIRS) score was calculated for each @entity1 . 78 admissions of elderly @entity308 @entity1 , who had attempted suicide before hospitalization, were examined. The comparison group (n=87) consisted of the subsequent admission of a similar but not suicidal pre-admission @entity1 . The CIRS total score was significantly higher among suicidal @entity1 (10.2 vs. 8.0; p=0.0008). Suicidal @entity1 scored higher in the vascular and the respiratory sections of CIRS. Our results support reported findings of higher rates of illness among suicidal elderly @entity1 . The CIRS may be considered an additional tool in assessing risk for suicide in elderly @entity146 subjects.

title: Suicide attempts and burden of XXXX among @entity308 elderly inpatients.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder', 'depressed']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['physical illness']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity221 :: (MESH:D005334,Disease) :: ['physical illness']


abstract: OBJECTIVES: The purpose of this study is to illustrate a rare @entity1462 and to make a literature review. @entity1 : @entity4917 is a @entity4670 which characterized by @entity600 , varicosities and bony or soft tissue @entity1184 . This disease is subject to significant morbidity like @entity548 , @entity1150 , @entity887 and in some cases enlargement of limb that may require amputation. Our case study was a young @entity1 of twenty years suffering since birth, from a @entity158 , @entity11728 and enlarged left lower limb that reached 2.5 cm. The distal @entity1184 at the big toe which the site of a botriomycoma (telengectasic @entity738 ). The inner side of the thigh was also the site of small port-wine stains and varicose of the great saphenous vein. Vascular Doppler ultrasound, skeletal computed tomography and angio-MRI of the limb indicated a @entity4917 . A surgical abstention was decided. The @entity1 underwent only to resection of the toe's botriomycoma followed by an elastic contention associated with "a heel pad compensation" and an anti platelet therapy to prevent @entity1150 and @entity887 . CONCLUSION: The syndrome of @entity4917 is a rare @entity1462 . The basic pathology can not be corrected. The treatment's aims are to control varicose veins, to prevent complications and to preserve aesthetic and functional prognosis of the leg.

title: [ XXXX : a case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient', 'PATIENT']

entities_list: @entity4670 :: ('MESH:D009358', 'Disease') :: ['congenital disorder']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['capillary malformation']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolic complications']

entities_list: @entity4917 :: ('MESH:D007715', 'Disease') :: ['klippel-Trenaunay disease', 'Klippel-Trenaunay', "Klippel-Trenaunay's syndrome"]

entities_list: @entity1462 :: ('MESH:D054079', 'Disease') :: ['vascular malformation']

answer: @entity4917 :: (MESH:D007715,Disease) :: ['Klippel-Trenaunay syndrome']


abstract: AIM: There has been great interest in recent years to take advantage of mesenchymal stem cells (MSCs) to treat @entity3851 . This study is aimed to evaluate clinical therapeutic effects of allogeneic MSC transplantation in @entity1575 caused by @entity792 . METHODS: The enrolled @entity1 with @entity1575 were assigned to receive allogeneic MSC infusions through a peripheral vein. The primary objective of this study was to assess the safety and effectiveness of MSCT in @entity1 with @entity792 -induced @entity82 . Secondary endpoints were to assess changes in the @entity3851 ( @entity3851 ) scores and liver functions after the transplantation. RESULTS: A total of 26 @entity1 were enrolled. Of these, 23 @entity1 received umbilical cord MSCT, two received cord blood MSCT and one received bone marrow MSCT. Three patents died of the complications caused by @entity82 and two @entity1 received liver transplantation after MSCT. Four @entity1 were lost to follow-up. The mean of @entity3929 transaminase values decreased 6 months, 1 and 2 years after the transplantation, but there were no statistical significance. The mean value of total @entity648 decreased at 6 months and 1 year follow-up. Average serum albumin levels improved at 6 months, 1 and 2 years follow-up. The mean value at 2 years increased significantly compared with the baseline value. A lowering of prothrombin time was seen at 6 months after MSCT. @entity3851 score improved at 6 months, 1 and 2 years of follow-up. No serious adverse events were observed during or 24 h after infusions of MSCs in any of the 26 @entity1 with @entity1575 . CONCLUSION: Based on this clinical trial, allogeneic MSCT through the peripheral vein probably is safe and seemingly has beneficial effect in @entity1 with @entity1575 . Therefore, allogeneic MSCT is a potential option for treatment of @entity1575 caused by @entity792 . Further studies with higher numbers of @entity1 are warranted to better clarify the impact and mechanisms of MSCT in @entity1575 .

title: Effects of allogeneic mesenchymal stem cell transplantation in the treatment of XXXX caused by @entity792 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity3851 :: ('MESH:D058625', 'Disease') :: ['end-stage liver disease', 'MELD', 'Models of End Stage Liver Disease']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

answer: @entity1575 :: (MESH:D008103,Disease) :: ['liver cirrhosis']


abstract: OBJECT: Obesity as a consequence of management of @entity976 is a well-described phenomenon related to the degree of @entity1640 involvement. However, weight change and @entity28 have not been analyzed in adult @entity1 . Therefore, the purpose of this study was 1) to evaluate the pattern of postoperative @entity1017 related to preoperative body mass index (BMI), 2) determine if postoperative @entity1017 is an issue in adult @entity1 , and 3) develop an objective MR imaging grading system to predict risk of postoperative @entity1017 and @entity28 in adults treated for @entity976 . METHODS: The authors retrospectively screened 296 @entity1 with known @entity976 for the following inclusion criteria: pathologically confirmed @entity976 , index surgery at the authors' institution, and operative weight and height recorded with at least 3 months of follow-up including body weight measurement. @entity1 aged 18 years or younger were excluded, yielding 28 cases for analysis. Cases of @entity976 were compared with age- and sex-matched controls ( @entity977 @entity1 ) to evaluate the pattern and significance of perioperative weight changes. RESULTS: Mean age was 46 +/- 17 years at surgery, and 64% of the @entity1 were male. Complete resection was achieved in 71% of cases. There was no correlation of preoperative BMI and postoperative @entity1017 testing in a linear model. Sixty-one percent and 46% of @entity1 had postoperative weight gains greater than 4 and 9%, respectively. Comparing @entity976 @entity1 (cases) to age- and sex-matched controls, the preoperative BMIs were similar (p = 0.93) between cases (mean 28.9 [95% CI 30.9-26.9]) and controls (mean 29.3 [95% CI 31.9-26.7]). However, there was a trend to a greater mean postoperative weight change (percentage) in cases (10.1%) than in controls (5.6%) (p = 0.24). Hypothalamic T2 signal change and irregular contrast enhancement correlated and predicted higher-grade @entity1640 involvement. Furthermore, they can be used to objectively grade @entity1640 involvement as the authors propose. Progressive @entity1640 involvement correlated with larger postoperative weight gains (p = 0.022); however, @entity1640 involvement did not correlate with preoperative BMI (p = 0.5). CONCLUSIONS: Postoperative @entity1017 in adult @entity1 undergoing surgery for @entity976 is a significant problem and correlates with @entity1640 involvement, as it does in pediatric @entity1 . Finally, objective MR imaging criteria can be used to predict risk of postoperative @entity1017 and aid in grading of @entity1640 involvement.

title: Magnetic resonance imaging-graded @entity1640 compression in surgically treated @entity976 determining XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenoma']

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['craniopharyngiomas', 'pediatric craniopharyngioma', 'craniopharyngioma']

answer: @entity28 :: (MESH:D009765,Disease) :: ['postoperative obesity']


abstract: Previously we demonstrated the expression of the long form of the leptin receptor in rodent pancreatic beta-cells and an inhibition of insulin secretion by leptin via activation of @entity855 -sensitive @entity972 channels. Here we examine pancreatic islets isolated from pancreata of @entity1 donors for their responses to leptin. The presence of leptin receptors on islet beta-cells was demonstrated by double fluorescence confocal microscopy after binding of a fluorescent derivative of @entity1 leptin (Cy3-leptin). Leptin (6.25 nM) suppressed insulin secretion of normal islets by 20% at 5.6 mM @entity413 . Intracellular @entity460 responses to 16.7 mM @entity413 were rapidly reduced by leptin. @entity2690 messenger ribonucleic acid expression in islets was inhibited by leptin at 11.1 mM, but not at 5.6 mM @entity413 . Leptin also reduced @entity2690 messenger @entity10731 levels that were increased in islets by treatment with 10 nM @entity5445 in the presence of either 5.6 or 11.1 mM @entity413 . These findings demonstrate direct suppressive effects of leptin on insulin-producing beta-cells in @entity1 islets at the levels of both stimulus-secretion coupling and gene expression. The findings also further indicate the existence of an @entity2270 in @entity1 in which insulin stimulates leptin production in adipocytes and leptin inhibits the production of insulin in beta-cells. We suggest that dysregulation of the @entity2270 in @entity28 individuals due to defective leptin reception by beta-cells may result in chronic @entity3190 and may contribute to the pathogenesis of adipogenic @entity6 .

title: Leptin suppression of insulin secretion and gene expression in @entity1 pancreatic islets: implications for the development of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity2690 :: ('3630', 'Gene') :: ['proinsulin', 'Proinsulin']

entities_list: @entity5445 :: ('2641', 'Gene') :: ['glucagon-like peptide-1']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia']

entities_list: @entity10731 :: ('CHEBI:33697', 'Chemical') :: ['ribonucleic acid']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity2270 :: ('MESH:C566610', 'Disease') :: ['adipoinsular axis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['adipogenic diabetes mellitus']


abstract: BACKGROUND: Plain chest film is the most convenient and common tool used to evaluate the response of @entity2 to chemotherapy. Many authors tried to evaluate the use of plain chest films to predict chemotherapy response. This study investigated a new factor which could be used to predict the chemotherapy response of @entity151 ( @entity151 ). METHODS: Sixty-two @entity1 with cytopathologically proven @entity151 receiving at least two courses of chemotherapy were included in this study. Among these @entity1 , thirty-nine @entity1 received six courses of chemotherapy. The regimens of chemotherapy are @entity2879 (100 mg/m2) and @entity900 (25 mg/m2). We divided these @entity1 into two groups according to whether a well-defined @entity358 excluding hilar and mediastinal lymphoadenopathy, could be identified on plain chest X-ray (CXR). Group I consisted of 31 @entity1 with identified lesions on the CXR; group II consisted of 31 @entity1 with unidentifiable lung lesions. CXRs were taken each time before chemotherapy and were collected and compared to evaluate the chemotherapy response. The 39 @entity1 receiving six course of chemotherapy, were further divided into group I (n = 19) and group II (n = 20) to evaluate the chemotherapy response. RESULTS: After two courses of chemotherapy, we found 23 @entity1 [74.2% (23/31)] in group I had partial response(PR) as compared to 12 @entity1 [38.7% (12/31)] in group II (P < 0.05). For the 39 @entity1 receiving six courses of chemotherapy, we could find only five @entity1 [16.1% (5/19)] in group I who had a complete response (CR) as compared to 17 @entity1 [85% (17/20)] in group II (P < 0.001). CONCLUSION: For @entity1 with @entity151 , a well-defined lung lesion on a CXR could be an important new factor to predict the chemotherapy response. It could predict less responsiveness to chemotherapy.

title: Existence of a well-defined @entity358 on plain chest film predicts poor response of chemotherapy in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['Cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['Etoposide']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary lesion']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung cancer']

answer: @entity151 :: (MESH:D055752,Disease) :: ['small cell lung cancer']


abstract: In a prospective randomized trial parietal cell vagotomy ( @entity1485 ) was compared with truncal vagotomy with drainage (TV) in the treatment of duodenal @entity1066 . The material consists of 106 @entity1 , 50 TV and 56 @entity1485 . Basal and maximal acid output (BAO, MAO) were measured preoperatively, 6 weeks and 12 months postoperatively. The clinical results were judged from a modified Visick grading system 1-6 years postoperatively. BAO 6 weeks after @entity1485 was reduced with 60% in average and 12 months postoperatively with 45%. After TV the BAO was reduced with 53% 6 weeks postoperatively and 34% 12 months postoperatively. MAO was reduced with 47% 6 weeks after @entity1485 and with 31% 12 months postoperatively. After TV the reduction of MAO was 50% and 44%, respectively. After @entity1485 62% of the @entity1 were insulin positive at the first postoperative examination and 78% one year later. After TV 46% of the @entity1 had a positive insulin test at the first postoperative examination and 50% one year later. In the @entity1485 group 9 @entity1 (16%) have got recurrences during the 1-6 years observation time, in the TV group there were 4 recurrences (8%). In the @entity1485 group 24% of the @entity1 with pyloric or prepyloric @entity1066 got recurrences and 13% of the @entity1 with duodenal @entity1066 . In the TV group the number of recurrences was 13% and 6%, respectively. At the modified Visick classification 71% of the @entity1 in the @entity1485 group were graded as I and II, 4% as III and 25% graded as IV. After TV 83% of the @entity1 were graded as I and II, 4% as III and 13% graded as IV. The results from this study do not allow us to recommend @entity1485 before TV and it should be seriously questioned if it shall at all be performed on prepyloric ulcers.

title: Parietal cell vagotomy and truncal vagotomy as treatment of duodenal XXXX . A prospective randomized trial.

answer: @entity1066 :: (MESH:D014456,Disease) :: ['ulcer']


abstract: BACKGROUND: The aim of this study was to describe the computed tomography (CT)-imaging features of @entity8 (E-AMLs) to understand and recognize this new category of @entity703 . METHODS: Institutional review board approval was obtained for this retrospective study. Clinical data and preoperative CT images of 11 cases of E-AML were retrospectively analyzed. All @entity1 had unenhanced and tri-phase dynamic enhanced CT examination. CT-imaging features including @entity5 size, existence of fat and @entity730 , enhancement degree, enhancement pattern, and enhancement heterogeneity were evaluated. RESULTS: The @entity1 were ten @entity1 and one @entity1 . The size of @entity5 ranged from 1.8 to 10.3  cm. All of them had distinct edges; one had a lobulated appearance, ten had bulging contour of the involved kidney, and four lesions had intratumoral fat. Eight of the E-AMLs demonstrated @entity536 , two as iso-attenuation, and one as hypo-attenuation compared with renal parenchyma on unenhanced CT images. Contrast-enhanced CT features were markedly heterogeneous in eight cases (73 %). The predominant enhancement pattern was rapid wash-in to slow wash-out (91 %). CONCLUSIONS: The radiological appearance of most E-AMLs has a tendency to be hyper-attenuated on precontrast CT with or without fat component and demonstrates a rapid wash-in to slow wash-out dynamic enhancement pattern.

title: CT-imaging features of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'man']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal epithelioid angiomyolipomas']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity536 :: ('MESH:C538265', 'Disease') :: ['hyper-attenuation']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal epithelioid angiomyolipoma']


abstract: OBJECTIVE: In @entity1860 ( @entity1860 ), increased cellular turnover of hematopoietic cells driven by the oncogene @entity1861 leads to accelerated @entity10205 @entity3207 despite increased telomerase activity. It has been postulated that shortened @entity10205 , particularly in the context of increased telomerase activity, might facilitate accumulation of genetic aberrations and, consequently, disease progression from chronic phase to accelerated phase and @entity9638 . Therefore, inhibition of telomerase might be a promising approach in @entity1860 therapy. MATERIAL AND METHODS: To investigate the therapeutic potential of telomerase inhibition in this model disorder, we used a small molecule telomerase inhibitor, @entity25083 as well as expression of a dominant-negative mutant of @entity2215 (DNhTERT-IRES-GFP) in the @entity876 -negative @entity1860 cell line K562 and characterized the effects in long-term culture. Furthermore, we expressed an inducible @entity876 construct (vector pBabe-p53ER(tam)) via retroviral transduction in cells with critically short @entity10205 and in cells with a normal @entity10205 length to explain the role of the @entity5 suppressor in response to critical @entity10205 @entity3207 in @entity1861 -positive cells. RESULTS: @entity25083 -treated bulk cultures did not show altered growth kinetics despite significant @entity10205 @entity3207 to a critical length of approximately 5 kb. In comparison, DNhTERT-expressing clones either lost @entity10205 length, leading to a significant but transient slow down in proliferation but eventually all escaped senescence/crisis (group I) or, alternatively, remained virtually unaffected despite measurable telomerase inhibition (group II). Further analyses of group I clones revealed @entity16 response and an accumulation of dicentric chromosomes. However, upon restoration of @entity876 in telomerase-negative K562 clones with critically short @entity10205 , immediate reinduction of apoptosis and complete eradication of cells was observed, whereas vector control cells continued to escape from crisis. CONCLUSIONS: These results suggest that the success of strategies aimed at telomerase inhibition in @entity1860 is highly dependent on the presence of functional @entity876 and should be explored preferentially in chronic phase @entity1860 .

title: Functional XXXX is required for effective execution of telomerase inhibition in @entity1861 -positive @entity1860 cells.

entities_list: @entity10205 :: ('MESH:C536801', 'Disease') :: ['telomeres', 'telomere']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['impaired DNA damage']

entities_list: @entity9638 :: ('MESH:D001752', 'Disease') :: ['blast crisis']

entities_list: @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myeloid leukemia', 'CML blast crisis']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: OBJECTIVE: The aim of this study was to assess safety and efficiency of a limited vaginal hysterectomy after brachytherapy in @entity1 with early @entity2622 without unfavorable prognostic factors. All @entity5 were less than 1.5 cm in diameter. MATERIAL AND METHODS: Between October 1992 and December 1995, 22 @entity1 with @entity5 (stage Ia2 with vascular invasion, 3 cases; stage @entity3846 , 19 cases) were included in this study. @entity1 underwent the following procedures: single utero-vaginal brachytherapy after a previous negative laparoscopic lymphadenectomy (median number of lymph nodes: 12) followed 6 weeks later by a limited vaginal hysterectomy. RESULTS: Two mild intraoperative complications were noted. @entity548 (100 cc) occurred in one @entity1 during lymphadenectomy and another @entity1 experienced @entity1494 during hysterectomy. These two complications were successfuly controlled with no need for laparotomy. Only one late complication was observed and was evaluated as a bladder grade G2(b) according to the Franco-Italian glossary. With a 30 (22-50) month follow-up, no recurrence was reported. CONCLUSION: These results appear promising in @entity1 with @entity189 but remain to be confirmed on a larger scale.

title: Brachytherapy and vaginal hysterectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Venous hemorrhage']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder injury']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['low-stage uterine cervix carcinoma', 'tumors']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['uterine cervix carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['very early cervix carcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['low-stage uterine cervix carcinoma']


abstract: Inhibition of @entity1024 ( @entity143 ) receptor function by @entity1068 ( @entity167 ) and interactions between @entity167 and the noncompetitive @entity143 receptor antagonist @entity4320 were examined in neocortical neurons from @entity35 and @entity1 embryonic kidney (HEK) 293 cells expressing recombinant @entity143 receptors. @entity1068 inhibited receptor function at concentrations in the 10 to 100 mM range in cortical neurons. @entity167 inhibition of @entity143 receptor function decreased as a function of time in culture over a 4-wk period. No difference in @entity167 inhibition of @entity140 / @entity4176 receptor function was observed in neurons from 2- to 4-wk-old cultures. The time course of decreased @entity167 inhibition paralleled a developmental decrease in inhibition by the noncompetitive @entity143 receptor antagonist @entity4320 in these cortical neurons. Inhibition by @entity167 was decreased in magnitude in the presence of 10 microM @entity4320 in 2- to 3-wk-old cortical neurons, but not in 1-wk-old neurons. @entity4320 inhibited the function of recombinant @entity143 receptors expressed in HEK 293 cells. Consistent with earlier reports, @entity4320 selectively inhibited responses mediated by recombinant receptors containing the @entity13069 subunit at concentrations up to 10 microM. @entity167 also inhibited the function of recombinant @entity143 receptors expressed in HEK 293 cells. The potency of @entity167 for inhibiting responses differed slightly among receptors containing different R2 subunits, especially at low @entity167 concentrations. Finally, @entity4320 did not alter the effect of @entity167 on recombinant R2A or 2B-containing @entity143 receptors.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Developmental decrease in @entity1068 inhibition of @entity1024 receptors in @entity35 neocortical neurons: relation to the actions of XXXX .

entities_list: @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate']

entities_list: @entity4320 :: ('MESH:C010739', 'Chemical') :: ['ifenprodil', 'Ifenprodil']

entities_list: @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']

answer: @entity4320 :: (MESH:C010739,Chemical) :: ['ifenprodil']


abstract: Gut atrophy develops during prolonged total parenteral nutrition ( @entity8856 ). @entity8856 solutions do not contain @entity1160 , an energy substrate of the intestinal tract. This study evaluated the effect of addition of @entity9640 to @entity8856 on gut @entity1568 content, histology, and disaccharidase enzyme activity. Five groups of six Fisher 344 @entity35 received @entity35 chow, D5W, @entity8856 (23% calories as lipid), or @entity8856 with 1 or 2% @entity9640 . Animals given @entity8856 received 30 kcal and 0.22 g @entity1568 /100 g/day. Metabolic cages allowed @entity1568 balance for each group. After 6 days infusion, stomach, small bowel, and colon were assayed for total @entity1568 and sucrase, @entity12115 , and maltase activity. Mucosal height and @entity1560 of the liver were determined from histologic sections. Adding either 1 or 2% @entity9640 resulted in no toxic clinical effects. @entity1160 preserved intestinal @entity1568 content of the stomach and colon compared to standard @entity8856 and increased @entity1568 content of small bowel to greater than that in chow-fed animals. @entity1160 maintained mucosal height of the stomach and colon, but was no better than @entity8856 alone in maintenance of small bowel mucosal height. One percent @entity1160 increased and standard @entity8856 depressed maltase activity compared to chow. Standard @entity8856 and 1% @entity1160 both stimulated sucrase and @entity12115 activity compared to chow. Addition of 1 or 2% @entity1160 protected the liver from @entity1560 seen with standard @entity8856 . These studies would suggest the addition of @entity1160 might be beneficial during provision of standard total parenteral nutrition.

title: Use of XXXX in total parenteral nutrition.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty infiltration']

entities_list: @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['Glutamine', 'glutamine']

entities_list: @entity9640 :: ('CHEBI:18050', 'Chemical') :: ['L-glutamine']

answer: @entity9640 :: (CHEBI:18050,Chemical) :: ['L-glutamine']


abstract: CONCLUSION: Stimulus biasing modulated the amplitude of the tone burst evoked summating potential (SP) in ears affected by @entity9303 less than in normal ears. A reduced SP bias ratio added diagnostic accuracy for the diagnosis of @entity9303 . OBJECTIVES: To evaluate the effect of stimulus biasing on the @entity1 tone burst SP, and to determine if stimulus biasing could contribute to the electrocochleography as a means of confirming the diagnosis of @entity9303 . @entity1 AND METHODS: @entity1 referred for transtympanic electrocochleography (TT ECochG) were assessed prospectively on clinical grounds according to the AAO-HNS criteria and a scale devised by one of the authors. A Meniere's group of ears and a non-Meniere's group of ears was determined. The ears opposite a Meniere's ear were not included in the analysis. The ratio of the click SP amplitude and the action potential (AP) amplitude (SP/AP ratio), the tone burst SP amplitude at 500 Hz,1 kHz, 2 kHz and 8 kHz, and the effect of stimulus biasing on the tone burst SP were measured. RESULTS: A unipolar stimulus biasing ratio established for the modulation of the 1 kHz tone burst SP separated the Meniere's ears from the non-Meniere's ears with a sensitivity of 85% at a specificity of 80.6% and the difference between groups reached statistical significance (p=0.016). The 1 kHz SP amplitude measurements and the stimulus biasing measurements were superior to the click SP/AP ratio for identifying the Meniere's group. A combination of 1 kHz SP amplitude measurements and SP bias ratio separated the Meniere's ears from the non-Meniere's ears with an accuracy of 85%.

title: A comparison of three methods of using transtympanic electrocochleography for the diagnosis of XXXX : click summating potential measurements, tone burst summating potential amplitude measurements, and biasing of the summating potential using a low frequency tone.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'PATIENTS', 'Patients']

entities_list: @entity9303 :: ('MESH:D008575', 'Disease') :: ["Meniere's disease"]

answer: @entity9303 :: (MESH:D008575,Disease) :: ['Meniere's disease']


abstract: BACKGROUND: The present study evaluated the clinical significance of @entity3274 , an antiapoptotic protein, in @entity12120 and @entity5772 . METHODS: @entity3274 expression was evaluated by immunohistochemistry in paraffin-embedded tissues of @entity12120 (n=25) and @entity5772 (n=61). RESULTS: Cytoplasmic expression was predominantly seen in 80% and 70% of @entity1 with @entity12120 and @entity189 , respectively. @entity3274 expression was found to be significantly lower in @entity286 users than in non- @entity286 users. @entity3274 expression in @entity286 -using @entity12120 and @entity189 @entity1 was compared by grouping the @entity189 @entity1 according to lymph node status and disease stage. @entity189 @entity1 with @entity5 -positive lymph nodes had significantly lower @entity3274 expression than @entity1 with negative lymph nodes and @entity12120 . Further, a trend towards an inverse correlation was observed with @entity876 and @entity1722 . In univariate and multivariate survival analysis, @entity1 subgroups with 2+ or 3+ marker positivity ( @entity3274 negativity, @entity876 and @entity1722 positivity) had a reduced overall survival compared with @entity1 subgroups with 1+ marker positivity or negativity. CONCLUSION: @entity3274 negativity in association with @entity876 and @entity1722 positivity identified a subgroup of tongue @entity5 @entity1 with an @entity146 phenotype. Hence, an antiapoptotic protein, @entity3274 , was found to be down-regulated in chewing- @entity286 -mediated tongue carcinogenesis.

title: Cytoplasmic localization of @entity3274 in XXXX and @entity5772 : correlation with @entity876 and @entity1722 in @entity189 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinoma', 'carcinoma']

entities_list: @entity12120 :: ('MESH:D007971', 'Disease') :: ['leukoplakia']

entities_list: @entity5772 :: ('MESH:D014062', 'Disease') :: ['carcinoma of the tongue']

answer: @entity12120 :: (MESH:D007971,Disease) :: ['leukoplakia']


abstract: A retrospective analysis identified 161 consecutive adults with @entity981 who underwent allogeneic hematopoietic cell transplantation (HCT) with full-intensity (myeloablative) conditioning between 1998 and 2006. Median @entity1 age was 36.1 years. Seventy-six @entity1 were in first complete remission ( @entity3432 ), and 85 were in second or greater CR or in relapse. Fifty-nine @entity1 had @entity981 . A total of 159 @entity1 received chemotherapy plus total body irradiation for conditioning. @entity2132 prophylaxis included a calcineurin inhibitor plus @entity1499 or @entity618 . Sixty of the donors were related, and 101 were unrelated. A total of 110 @entity1 received @entity1261 -stimulated peripheral blood, 47 received bone marrow, and 4 received cord blood as the stem cell source. Fifty-five @entity1 relapsed at a median of 231 days after transplantation. The estimated 5-year probabilities of relapse-free survival, relapse, and nonrelapse mortality were 47%, 30%, and 29%, respectively. By multivariate analyses, transplantation while in @entity3432 was the most important predictor of successful transplantation. Pretransplantation evidence of minimal @entity66 , especially as detected by flow cytometric analysis, was associated with both lower overall survival and lower relapse-free survival. Compared with a similar cohort of @entity1 undergoing transplantation between 1990 and 1997, overall survival was similar for @entity1 undergoing transplantation in @entity3432 , with lower nonrelapse mortality being offset by higher rates of relapse in @entity1 who underwent transplantation more recently.

title: Allogeneic hematopoietic cell transplantation with full-intensity conditioning for adult XXXX : results from a single center, 1998-2006.

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['Philadelphia chromosome-positive acute lymphoblastic leukemia', 'acute lymphoblastic leukemia']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['granulocyte-colony stimulating factor']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['Graft-versus-host disease']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']


abstract: BACKGROUND: Single-institution data suggest that treatment with radiation and @entity1600 ( @entity1600 ) may be an appropriate alternative to mastectomy for T0N+ @entity0 . Population-based multi-institutional data supporting this approach are lacking. METHODS: The cause-specific survival (CSS) and overall survival (OS) of @entity1 with T0N+M0 ductal, lobular, or mixed @entity0 in the Surveillance, Epidemiology, and End Results database from 1983 to 2006 were analyzed. Groups were defined as: 1) no @entity1600 , mastectomy, or @entity138 (observation); 2) @entity1600 only; 3) mastectomy plus @entity1600 with or without postmastectomy radiation (Mast); and 4) breast-conserving therapy (BCT) with @entity1600 and radiation (BCT). RESULTS: In total, 750 of 770,030 @entity1 with @entity0 had T0N+M0 disease (incidence, 0.10%), and 596 of those @entity1 underwent @entity1600 (79.5%). @entity1 who underwent Mast or BCT (n = 470) had a 10-year OS rate of 64.9% compared with 58.5% for @entity1 who underwent @entity1600 only (n = 126; P = .02) and 47.5% for @entity1 who underwent observation only (n = 94; P = .04). The 10-year CSS rate was 75.7% for @entity1 who underwent BCT versus 73.9% for @entity1 who underwent Mast (P = .55). In multivariate analysis of CSS for @entity1 who underwent Mast or BCT, the following factors were correlated with an unfavorable outcome: positive @entity172 receptor status (hazard ratio [HR], 0.48; 95% confidence interval [CI], 0.24-0.96; P = .04), >/=10 positive lymph nodes (HR, 5.7; 95%CI, 2.4-13.4; P </= .01), and <10 resected lymph nodes (HR, 42.9; 95%CI, 1.2-7.1; P = .02). Mast did not improve CSS compared with BCT (HR, 1.09; 95%CI, 0.57-2.1; P = .79). CONCLUSIONS: Definitive locoregional treatment with either Mast or BCT improved the outcome of @entity1 with T0N+ @entity0 , and no difference in survival was observed between the treatments. @entity5 2010. (c) 2010 American @entity5 Society.

title: Population-based analysis of occult primary XXXX with @entity1600 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['axillary lymph node dissection', 'ALND']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: PURPOSE: Hormone-related factors have been associated with @entity43 , the strongest being parity and oral contraceptive use. Given reductions in birth rates and increases in oral contraceptive use over time, associations in more recent birth cohorts may differ. Furthermore, consideration of @entity43 heterogeneity (i.e., @entity3 ) may contribute to a better understanding of etiology. We examined hormone-related factors in relation to @entity43 risk overall, for @entity5 , as well as borderline @entity5 . METHODS: A population-based case-control study was carried out in Montreal, Canada from 2011 to 2016, including 496 cases and 908 controls. For each hormone-related variable, adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using logistic regression for @entity43 overall, and using polytomous logistic regression for associations by @entity5 behavior and @entity43 type. RESULTS: Parity was inversely associated with risk overall and by @entity5 behavior and type, with a stronger OR (95% CI) for Type I [0.09 (0.04-0.24) for >= 3 full-term births vs. nulliparity] vs. Type II [0.66 (0.43-1.02)] invasive @entity5 ; the OR (95% CI) for borderline @entity5 was 0.41 (0.22-0.77). Oral contraceptive ever use was not associated with risk overall, but >= 10  years of use vs. never use reduced risk, particularly for invasive @entity5 . A history of @entity46 was most strongly associated with @entity5 . Associations with other factors were less clear. CONCLUSIONS: These results suggest that associations with some hormone-related factors may differ between borderline and invasive @entity43 .

title: Hormonal and reproductive factors and the risk of XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Type I and II ovarian cancers', 'ovarian cancer']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Type I cancers', 'cancers', 'Type I and Type II cancers', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['Type I/II invasive cancers']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: BACKGROUND AND STUDY AIMS: To summarize the published literature on assessment of appropriateness of colonoscopy for the investigation of functional bowel symptoms, and report appropriateness criteria developed by an expert panel, the 2008 European Panel on the Appropriateness of Gastrointestinal Endoscopy, EPAGE II. METHODS: A systematic search of guidelines, systematic reviews and primary studies regarding the evaluation and management of functional bowel symptoms was performed. The RAND/UCLA Appropriateness Method was applied to develop appropriateness criteria for colonoscopy for these conditions. RESULTS: Much of the evidence for use of colonoscopy in evaluation of chronic @entity490 , and/or @entity1142 and/or abdominal bloating is modest. Major limitations include small numbers of @entity1 and lack of adequate characterization of these @entity1 . Large community-based follow-up studies are needed to enable better definition of the natural history of @entity1 with @entity29 . Guidelines stress that alarm features ("red flags"), such as @entity548 , @entity417 , @entity353 , nocturnal symptoms, family history of @entity694 , age of onset > 50 years, and recent onset of symptoms should all lead to careful evaluation before a diagnosis of @entity29 is made. EPAGE II assessed these symptoms by means of 12 clinical scenarios, rating colonoscopy as appropriate, uncertain and inappropriate in 42 % (5/12), 25 % (3/12), and 33 % (4/12) of these, respectively. CONCLUSIONS: Evidence to support the use of colonoscopy in the evaluation of @entity1 with @entity29 and no alarm features is lacking. These @entity1 have no increased risk of @entity694 and thus advice on screening for this is not different from that for the general population. EPAGE II criteria, available online (http://www.epage.ch), consider colonoscopy appropriate in @entity1 of > 50 years with @entity132 , but not in @entity1 with isolated chronic @entity490 .

title: Appropriateness of colonoscopy in Europe (EPAGE II). XXXX : pain, @entity1142 and bloating.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['rectal bleeding']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity132 :: ('MESH:D010468', 'Disease') :: ['chronic or new-onset bowel disturbances']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['functional bowel disorders', 'functional bowel disorder']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

answer: @entity29 :: (MESH:D015212,Disease) :: ['Functional bowel disorders']


abstract: We investigated the asialo-agalactofetuin galactosyltransferase solubilized by @entity6000 from a @entity1 @entity150 line (cell-associated form). The specific activity of this enzyme was dependent on cell population density, being about 50% higher in cells from confluent than from sparse cultures. We compared the properties of this enzyme with those of a galactosyltransferase isoenzyme present in the culture medium (soluble form). Electrophoresis on nondenaturing @entity2975 gels showed the two forms to be isoenzymes, in that the mobility of the soluble enzyme was greater than that of the cell-associated enzyme. The isoenzymes differed in that the Km for @entity858 - @entity3649 of the cell-associated enzyme (1 X 10(-5) M) was one-half that of the soluble isoenzyme. The isoenzymes differed by 1 order of magnitude in their affinity for a fetuin-derived acceptor with a Km of 16 X 10(-5) M for the cell-associated and 1.2 X 10(-5) M for the soluble form, although the Km for ovalbumin and asialomucin as acceptor was similar for both. Both enzymes were active over a broad pH range and their response to divalent cations was the same: the most efficient cation was @entity3281 ; but modest activity was detected in the presence of either @entity3280 or @entity515 . As determined by gel filtration on Sepharose 6B, the cell-associated galactosyltransferase showed a molecular weight of 66,000, whereas that of the soluble form was 51,000. Limited proteolysis of the cell-associated enzyme with thermolysin and subsequent analysis by nondenaturing @entity2975 gel electrophoresis demonstrated that the cell-associated enzyme could be converted to an isoenzyme showing the same electrophoretic mobility as the soluble enzyme present in the culture medium, presumably by removal of a portion of the peptide chain. The same result was obtained by treating the cell-associated enzyme with a cell extract. This suggests but does not prove that the soluble enzyme secreted or shed into the medium is produced from the cell-associated form by an endogenous protease.

title: Comparison of cell-associated and soluble galactosyltransferase isoenzymes from a XXXX @entity150 line.

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder transitional cell carcinoma']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity3649 :: ('MESH:D005690', 'Chemical') :: ['galactose']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To determine if @entity935 (D3) receptor genotypes are associated with @entity3206 and response to ovulation induction with @entity4082 . DESIGN: Clinical and laboratory characteristics of anovulatory @entity1 and ovulatory controls were compared with findings at the DNA level. SETTING: An outpatient clinic at an university medical center. @entity1 : One hundred eighty @entity1 Hispanic female volunteers (130 of these with documented ovulatory status) were studied. INTERVENTIONS: Genomic DNAs were extracted from each @entity1 . Polymerase chain reaction with subsequent restriction digest was performed to analyze the D3 receptor allele status (two possible alleles). MAIN OUTCOME MEASURES: Menstrual history, serum T, and midluteal serum Ps from spontaneous and @entity4082 cycles were correlated with D3 receptor genotype. RESULTS: Hispanic females with the 22 genotype compared with the other genotypes (11 and 12) were more likely to have irregular menses, an elevated serum T (> or = 70 ng/dL [conversion factor to SI unit, 3.467]), and @entity3206 . These @entity1 tended to be resistant to ovulation induction requiring a significantly higher dose of @entity4082 to achieve an ovulatory response (22 genotype [mean +/- SEM] [140.0 +/- 19.0 mg] versus 11 [77.1 +/- 17.5 mg] or 12 [69.2 +/- 13.1 mg]). This effect was independent of @entity1 age, weight, or serum T level. CONCLUSIONS: @entity3206 may have a genetic component. Genetic analysis may be useful in predicting resistance to ovulation induction with @entity4082 .

title: A @entity935 D3 receptor genotype is associated with XXXX and resistant to ovulation induction with @entity4082 in female Hispanics.

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene citrate', 'clomiphene']

entities_list: @entity3206 :: ('MESH:D000858', 'Disease') :: ['anovulation', 'Hyperandrogenic chronic anovulation', 'hyperandrogenic chronic anovulation']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient', 'PATIENTS']

answer: @entity3206 :: (MESH:D000858,Disease) :: ['hyperandrogenic chronic anovulation']


abstract: Many epidemiological studies have demonstrated that vegetable food consumption is associated with a reduced risk of @entity65 . The beneficial effects have been attributed to the content of bioactive molecules present in large quantities in plant food. The main proposal of this study was to evaluate in vivo whether micronutrient-enriched rapeseed oils (optimised oils) obtained using different crushing and refining procedures and characterised by different quantities and qualities of micronutrients, could have any beneficial effect on lipid profile and antioxidant status of plasma and liver. @entity35 were fed a high-fat diet for 4 weeks. The lipid source consisted of 20% optimised rapeseed oils with different quantities and qualities of micronutrients. The control group received traditional refined rapeseed oil. The experimental optimised oils all had a hypolipidaemic effect. In the group fed the highest levels of micronutrients, the reduction in plasma and hepatic @entity1674 reached 25% and 17%, respectively, that of @entity165 20% and 14%, respectively. In plasma, the ferric antioxidant capacity, @entity224 dismutase, @entity2041 peroxidase and @entity2041 significantly increased and lipid peroxidation decreased in parallel with the enhancement of micronutrients. The same trend was observed in the liver, except for @entity2041 peroxidase which was not affected by optimised oils. These results indicate that a regular intake of optimised rapeseed oils can help to improve lipid status and prevent oxidative stress, providing evidence that optimised oils could be a functional food with potentially important cardioprotective properties.

title: Micronutrient-enriched rapeseed oils reduce XXXX risk factors in @entity35 fed a high-fat diet.

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione', 'reduced glutathione']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']


abstract: INTRODUCTION: There remains a lack of high quality randomised trial evidence for the use of adjuvant chemotherapy in @entity5 , particularly in the presence of high risk features such as extramural @entity3 (EMVI). The aim of this study was to explore this issue through a survey of colorectal surgeons and gastrointestinal oncologists. METHODS: An electronic survey was sent to a group of colorectal surgeons who were members of the Association of Coloproctology of Great Britain and Ireland. The survey was also sent to a group of gastrointestinal oncologists through the Pelican @entity5 Foundation. Reminder emails were sent at 4 and 12 weeks. RESULTS: A total of 142 surgeons (54% response rate) and 99 oncologists (68% response rate) responded to the survey. The majority in both groups of clinicians thought EMVI was an important consideration in adjuvant treatment decision making and commented routinely on this in their multidisciplinary team meeting. Although both would consider treating @entity1 on the basis of EMVI detected by magnetic resonance imaging, oncologists were more selective. Both surgeons and oncologists were prepared to offer @entity1 with EMVI adjuvant chemotherapy but there was lack of consensus on the benefit. CONCLUSIONS: This survey reinforces the evolution in thinking with regard to adjuvant therapy in @entity34 . Factors such as EMVI should be given due consideration and the prognostic information we offer @entity1 must be more accurate. Historical data may not accurately reflect today's practice and it may be time to consider an appropriately designed trial to address this contentious issue.

title: Adjuvant therapy decisions based on magnetic resonance imaging of extramural XXXX and other prognostic factors in colorectal cancer.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II rectal cancer', 'Cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['venous invasion']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']

answer: @entity3 :: (MESH:D009362,Disease) :: ['venous invasion']