abstract: Capillaria brochieri @entity8891 . is described in a @entity831 ( @entity4839 Schwartz, 1929) deceased from @entity294 . The male shows a unique structure of the caudal extremity: two flat paddles, with distal insertion, extend forward on each side of the ventral genital opening. The spicule (1,750 microns in length) shows a flattened anterior extremity and a tapered, curved posterior extremity. The cirrus is non-spiny and very long. Two narrow and very long lateral alae are present. The female bears a vulvar appendage. The egg shell shows an internal dense layer and an external layer of irregular width, showing pores and striations. The paper includes a study of the literature on Capillaria and Anatrichosoma from Primates and @entity1 . C. brochieri is the first species of Capillaria described from the intestine of the @entity831 . Because of the close analogies between @entity831 's and @entity1 's helminthes, it is possible that C. brochieri has to be considered in @entity1 pathology.

title: [Capillaria brochieri @entity8891 . (Nematoda: Capillariinae) intestinal parasite of the @entity831 ( XXXX ) in Zaire].

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity4839 :: ('9597', 'Species') :: ['Pan paniscus']

entities_list: @entity831 :: ('9598', 'Species') :: ['chimpanzee']

answer: @entity4839 :: (9597,Species) :: ['Pan paniscus']


abstract: AIM: To compare the analgesic efficacy of @entity616 with @entity3522 suppository and local anesthetic infiltration in @entity1 undergoing laparoscopy. METHODS: We studied 50 @entity1 undergoing laparoscopy for diagnostic and therapeutic purposes. Their ages ranged from 3 to 13 years, and all belonged to American Society of Anesthesiologists (ASA) class I or II. Anesthesia was carried out using the standard procedure. @entity1 were randomly assigned to one of two groups. Group 1 received @entity616 with @entity1341 1 mL/kg after anesthetic induction. Group 2 received @entity3522 suppository 3 mg/kg postinduction and local anesthetic infiltration at the port sites at the end of the procedure. @entity158 was assessed using the Hannallah objective @entity158 scale at 15, 30, 60, 120, and 360 minutes postextubation. RESULTS: The @entity158 scores were comparable in both groups at all times. Twelve percent of @entity616 @entity1 and 20% of @entity3522 @entity1 needed rescue analgesic, a statistically insignificant difference. In 2 @entity1 , @entity616 was technically difficult and they were excluded from the study. The incidence of side effects was low in our study. CONCLUSION: We find the analgesic efficacy of @entity3522 suppository combined with local anesthetic infiltration at port sites comparable to @entity616 . Given the necessarily invasive nature of @entity616 , we suggest the combined use of @entity3522 suppository with local anesthetic infiltration at port sites as a useful and more economical alternative for @entity1337 following pediatric laparoscopy.

title: Analgesic efficacy of XXXX versus @entity3522 suppository and local anesthetic infiltration following pediatric laparoscopy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['caudal block']

answer: @entity616 :: (MESH:D006327,Disease) :: ['caudal block']


abstract: @entity6794 ( @entity6794 ) is a rare @entity74 characterised by the rapid progression of a @entity158 , necrolytic @entity1066 . This study retrospectively identified @entity1 who were admitted and treated for @entity6794 during a 10-year period (2003-2013). Twenty-three @entity1 were included in this study, 16 @entity1 and seven @entity1 . The mean age at initial admission was 62.8 years (range 30 to 89 years). Lesions were localised to lower limb in 13 @entity1 , peristomal region in four, breast in three, and upper limb in one, and two @entity1 had @entity6794 at multiple sites. The variants of @entity6794 noted were ulcerative (18), bullous (2), vegetative (2), and pustular (1). @entity262 were observed in 11 @entity1 (47.8%). Systemic therapies were initiated in 21 @entity1 while two @entity1 received topical treatments. The mean length of hospital stay was 47 days (range 5 to 243 days) and five @entity1 died during their admissions. Seven @entity1 required readmissions for exacerbations of their @entity6794 . Our study showed that @entity1 admitted for treatment of @entity6794 had high morbidity and mortality. This study also highlights the importance of early and aggressive treatment of @entity1 admitted with @entity6794 as well as treating associated @entity2737 .

title: XXXX : a review of clinical features and outcomes of 23 cases requiring inpatient management.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity6794 :: ('MESH:D017511', 'Disease') :: ['Pyoderma gangrenosum', 'PG']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['Associated systemic diseases']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['systemic diseases and wound infections']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['dermatological disorder']

answer: @entity6794 :: (MESH:D017511,Disease) :: ['Pyoderma gangrenosum']


abstract: BACKGROUND: We used the Taiwan National Health Insurance Database for analysis and statistics to investigate the role of CT in diagnosing @entity697 . MATERIALS AND METHODS: All 10 046 @entity1 with @entity697 were selected and categorized into two groups based on those who did and did not receive CT 3 days before @entity697 diagnosis: non-CT and CT groups. A noteworthy outcome was the incidence of @entity298 within 90 days after diagnosis of @entity697 . RESULTS: The rate of using CT for @entity1 with @entity697 increased considerably from 7.9% to 52.9% from 2000 to 2010. The @entity298 incidence rates were 3.54% and 10.7% in the non-CT and CT groups, respectively. @entity1 who received CT on the same day exhibited a 3.8-fold higher risk of @entity298 than did those in the non-CT group. Those who underwent CT before diagnosis of @entity697 exhibited no significant difference of @entity298 risk when compared with those in the non-CT group. The CT group @entity1 were hospitalized 2.19 days longer than the non-CT group @entity1 . @entity1 who received CT before and on the same day were hospitalized 1.31 and 2.43 days longer than those who did not undergo CT. CONCLUSION: @entity1 who underwent CT exhibited higher risks of @entity298 and longer hospital stays compared with those who did not. Moreover, @entity1 who received CT on the same day of operation exhibited a higher risk of @entity298 than those who underwent @entity59698 days before operation.

title: Changing roles of computed tomography in diagnosing XXXX in emergency rooms.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute appendicitis']


abstract: @entity463 ( @entity463 multiforme, @entity11 ) represents both the most common and most malignant variant among numerous of primary @entity1313 . @entity2903 ( @entity2904 ) has been used for the treatment of @entity463 . However, less than 1/3 of @entity463 respond to @entity2904 -based therapies. Therefore, strategies to enhance the effect of @entity2904 are needed for more effective targeted therapeutics. Stress-activated protein kinases (SAPKs) @entity4675 and @entity1435 MAPK have been known to have apoptotic or anti-apoptotic effects depending on cell type and condition. On the other hand, @entity584 is a key regulator of cellular survival and has direct effects on the apoptosis machinery. In addition, it was discovered that @entity584 activation is primed by the activity of @entity4675 . We, therefore, examined whether inhibition of @entity4675 or @entity1435 potentiates @entity2904 -induced apoptosis in U87MG cells via inhibition of @entity584 activation. @entity2904 significantly induced @entity584 activation as well as @entity4675 or @entity1435 activation. Inhibition of @entity4675 suppressed @entity584 activation and potentiated @entity2904 -induced @entity137 . The phosphorylation of @entity9459 and @entity1835 , the downstream mediators of @entity584 , was also suppressed by the inhibition of @entity4675 . The present data strongly suggest that there may be a crosstalk between @entity4675 pathway and @entity584 pathway in @entity463 and that further investigation based on the present data may provide a valuable approach for enhancing @entity2904 -induced @entity137 in @entity463 .

title: Inhibition of @entity4675 potentiates XXXX -induced @entity137 in U87MG @entity463 cells via suppression of @entity584 phosphorylation.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity2903 :: ('MESH:C047246', 'Chemical') :: ['Temozolomide']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'formally glioblastoma', 'glioblastoma', 'Glioblastoma']

answer: @entity2903 :: (MESH:C047246,Chemical) :: ['temozolomide']


abstract: The functional role of @entity855 -dependent @entity972 (KATP) in @entity712 was investigated in isolated @entity840 hearts with @entity5217 and rimalkalim as inhibitor and activator, respectively. Monophasic action potential duration at 90% of repolarization (MAP50), left ventricular function, and cardiac energy status (31P nuclear magnetic resonance spectroscopy) were measured during normotoxic (95% O2) and @entity519 (20% O2) perfusion. In normoxic hearts, 1 microM @entity5217 did not affect MAP50, left ventricular function, and coronary flow (n = 4). In contrast, rimalkalim rapidly shortened MAP50 and left ventricular pressure (LVP) in a dose-dependent fashion (e.g., by 60.2 +/- 3.5 and 80.8 +/- 8.2%, respectively, with 0.6 microM rimalkalim). This latter effect was reversed by 1 microM ( @entity5217 (n = 4). With @entity519 perfusion, a reduction in LVP was observed, along with a shortening of the action potential (MAP90; 202 +/- 13 vs. 164 +/- 9 ms) and an increase in coronary flow. @entity5217 (1 microM) reversed the MAP90 shortening and the increase in coronary flow. In addition, @entity5217 increased LVP transiently (n = 4). When coronary flow of @entity519 hearts was kept constant, however, @entity5217 elicited a sustained positive inotropic effect (n = 7). After @entity5217 , an increase in LVP from 54 +/- 4 to 64 +/- 3 mmHg was observed, along with a reduction in the free energy change of @entity855 hydrolysis from -54.5 +/- 1.9 to -52.9 +/- 0.2 nJ/mol and a further increase in the coronary venous @entity859 from 269 +/- 48 to 1,680 +/- 670 nmol/l.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity519 -induced activation of KATP channels limits energy depletion in the XXXX heart.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['hypoxic cardiac failure']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity5217 :: ('MESH:D005905', 'Chemical') :: ['Glibenclamide', 'glibenclamide']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

answer: @entity840 :: (10141,Species) :: ['guinea pig']


abstract: OBJECTIVE: Few studies have examined @entity250 among Operations Enduring/Iraqi Freedom (OEF/ @entity23806 ) veterans with @entity1005 ( @entity1005 ). The present study investigated predictors of @entity323 [ @entity323 ] and self-reported sexual problems among 150 male combat veterans seeking outpatient treatment for @entity1005 within the Veterans Affairs healthcare system. METHOD: @entity1 completed clinical interviews and several questionnaires including measures of sexual arousal and sexual desire. A medical records review was also conducted to document evidence of an @entity323 diagnosis or associated medication use. RESULTS: An @entity323 diagnosis was present for 12% of the sample, and 10% were taking associated medications. Sexual arousal problems were reported by sixty-two percent of partnered veterans. Sexual desire problems were endorsed by 63% of the total sample, and by 72% of partnered veterans. Age was the only significant predictor of @entity323 diagnosis or medication use. Age, race, @entity1005 diagnosis (versus subclinical symptoms), @entity308 , and social support predicted self-reported sexual arousal problems; while race, combat exposure, social support, and avoidance/numbing symptoms of @entity1005 predicted self-reported @entity458 . CONCLUSIONS: Sexual problems are common among male OEF/ @entity23806 combat veterans seeking treatment for @entity1005 . Moreover, avoidance/numbing symptoms robustly predicted @entity458 . These findings highlight the importance of expanding assessment of @entity250 and support the need for additional research in this area.

title: Problems in sexual functioning among male OEF/ XXXX veterans seeking treatment for posttraumatic stress.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'ED']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual desire problems']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity23806 :: (4969,Gene) :: ['OIF']


abstract: OBJECTIVE: The aim was to examine the effect of dopaminergic medication on stimulus-response learning versus performing decisions based on learning. METHOD: To see the effect of dopaminergic therapy on stimulus-response learning and response selection, @entity1 with @entity191 ( @entity191 ) were either tested on and/or off their prescribed dose of dopaminergic therapy during different testing days. Forty @entity1 with @entity191 and 34 healthy controls completed the experiment on consecutive days. On Day 1, @entity1 learned to associate abstract images with spoken, "right" or "left" responses via feedback (Session 1). On Day 2, @entity1 recalled these responses (Session 2) and indicated the location (i.e., right or left of center) of previously studied images intermixed with new images (Session 3). RESULTS: @entity1 with @entity191 off medication learned stimulus-response associations equally well compared to healthy controls. Learning was impaired by dopaminergic medication. Regardless of medication status, @entity1 recalled the stimulus-response associations from Day 1 as well as controls. In Session 3 off medication, @entity1 demonstrated enhanced facilitation relative to controls and @entity1 on medication, when the stimulus location was congruent with the spoken response that was learned for the stimulus in Session 1. INTERPRETATION: @entity191 was comparable to that of healthy controls off medication. Learning was worsened by dopaminergic therapy in @entity191 . We interpret greater facilitation in @entity1 with @entity191 off medication for congruent responses as evidence of greater impulsivity. This motor or reflexive impulsivity was normalized by medication in @entity191 . These findings shed light on the cognitive profile of @entity191 and have implications for dopaminergic treatment.

title: Dopaminergic therapy affects learning and impulsivity in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD', 'Learning in PD']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: STUDY OBJECTIVE: To evaluate the effectiveness of @entity680 in suppressing coughing and @entity2146 during emergence from @entity5161 anesthesia. DESIGN: Randomized, double-blind, placebo-controlled study. SETTING: Operating rooms at a university medical center. @entity1 : 34 healthy ASA physical status I and II adult @entity1 scheduled to undergo oral surgical procedures. INTERVENTIONS: During emergence from anesthesia, @entity1 received either @entity680 15 micrograms/kg (in 10 ml) or saline (10 ml) when the end-tidal @entity5161 concentration reached 0.3%. MEASUREMENTS AND MAIN RESULTS: Hemodynamic variables were measured at one-minute intervals following administration of the study medication. A blinded observer recorded the time for @entity1 to spontaneously open their eyes and to follow commands after discontinuing the @entity5161 . The occurrence of coughing and @entity2146 prior to extubation was noted. @entity1 in the @entity680 treatment group exhibited a reduced incidence of coughing prior to extubation (6% vs. 83%, respectively) and a longer time interval until the onset of spontaneous movements (21.1 +/- 2.6 min vs. 14.6 +/- 1.7 min, respectively). The interval between the onset of movement and orientation was shorter in the @entity680 -treated @entity1 , resulting in similar extubation times for both groups. @entity680 administration was also associated with lower heart rate, systolic diastolic, and mean arterial pressure values during the emergence period. CONCLUSION: @entity680 decreased coughing, @entity2146 , and cardiovascular stimulation during emergence from @entity5161 anesthesia without prolonging the time of extubation.

title: XXXX suppresses coughing and @entity2146 during emergence from @entity5161 anesthesia.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane']

entities_list: @entity680 :: ('MESH:D015760', 'Chemical') :: ['Alfentanil', 'alfentanil']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

answer: @entity680 :: (MESH:D015760,Chemical) :: ['Alfentanil']


abstract: Cells expressing Fc receptors for IgE ( @entity7527 ) were identified in the peripheral blood from @entity1 with @entity483 and with @entity484 , and normal non-atopic subjects by using monoclonal antibodies to @entity1 lymphocyte @entity7527 , and to lymphoid cell-surface antigens by immunofluorescence staining. Based on the extent of the @entity1909 @entity1 were classified as severe (greater than 50% skin surface involved), moderate (50-10%) and mild (less than 10%). @entity1 with severe and moderate @entity483 had 5.9% and 5.7% @entity7527 + peripheral blood mononuclear cells (PBMC), respectively, that were significantly higher than percentages in mild @entity483 @entity1 (2.6%), severe to moderate @entity484 @entity1 (2.3%), mild @entity484 @entity1 (2.2%) and normal individuals (1.7%)(0.05 greater than P). In severe and moderate @entity483 @entity1 , 10% of @entity7527 + PBMC were T cells that preferentially expressed @entity405 , and the remainder B cells and monocytes. @entity7527 + T cells comprised 1% of peripheral T cells, while half or more of peripheral B cells expressed @entity7527 . In mild @entity483 @entity1 , @entity484 @entity1 and normal subjects. @entity7527 were expressed exclusively on 25-35% of peripheral B cells. Short-term treatment and long-term follow-up of @entity483 @entity1 revealed that changes in the @entity272 were related closely to fluctuations in the proportion of @entity7527 + PBMC. Total serum IgE levels and @entity1576 did not influence the percentage of @entity7527 . These findings suggest that the percentage of @entity7527 + PBMC reflects the extent of @entity483 .

title: @entity7527 / @entity7527 -positive lymphocytes in XXXX . I. The proportion of @entity7527 + lymphocytes correlates with the extent of @entity272 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients']

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin condition']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['atopic respiratory allergy']

entities_list: @entity7527 :: ('2208', 'Gene') :: ['Fc epsilon RII', 'Fc epsilon RII+ PBMC']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

entities_list: @entity484 :: ('MESH:D004485', 'Disease') :: ['eczematous dermatitis']

answer: @entity483 :: (MESH:D003876,Disease) :: ['atopic dermatitis']


abstract: Primary @entity3478 and @entity5 -like lesions of the vertebral column are rare in @entity1 . After operative @entity5 resection, 25 @entity1 under the age of 17 could be reviewed in a retrospective analysis. @entity3478 occurred only twice in the region of the vertebral body. No @entity85 was registered in 9 of 16 cases after @entity5 resection with and without laminectomy on one level. In contrast, after resection of one or both facets in combination with laminectomy cranial to L4 or thoracal, progressive @entity1513 was found within 6-22 months postoperatively in four cases. This required a secondary fusion. After primary fusion and instrumentation, no @entity85 was registered. In nine cases with a location of the @entity5 in the vertebral body, only two @entity1 developed a secondary instability of the spine. Both cases had no primary fusion. The other seven @entity1 with initial fusion and instrumentation showed no @entity85 within 24 up to 127 months postoperatively. These results are compared with data from the current literature.

title: [Secondary deformities after section of primary XXXX of the spine in @entity1 and adolescents].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity3478 :: ('MESH:D001859', 'Disease') :: ['Malignant bone tumors', 'bone tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'local tumor']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity']

answer: @entity3478 :: (MESH:D001859,Disease) :: ['bone tumors']


abstract: This 5-year follow-up study includes all @entity1 (n = 934; 50% females) treated for self-poisoning in Oslo during 1 year. Seventeen percent were considered suicide attempts upon admission, 25% among the nonabusers and 8% among the abusers. At follow-up, 122 @entity1 were dead (61% males). The mortality rate was highest among the abusers. The mortality rate was similar (13%) among those who were considered to be suicidal on admittance and those who were not. The causes of @entity204 were suicide (28%), @entity734 (16%), @entity299 (14%), accidents or @entity130 (11%), @entity988 (9%) and others (22%). The standard mortality rate was highly increased in all groups (8 times on average), highest among the female opiate abusers, whose rate was 63 times higher than expected. The increased suicide rates (87 times for females, 27 times for males), however, may be a more relevant measure of mental morbidity than the standard mortality rate. Logistic regression analysis demonstrated that male sex, age above 50 years and the lowest social group were factors on admission associated with @entity204 in the follow-up period. Age above 50 years and suicidal attempt on admission were associated with subsequent suicide. The study strongly supports the idea of self-destructiveness and slow suicide in @entity734 .

title: Suicide and other causes of @entity204 in a five-year follow-up of XXXX treated for self-poisoning in Oslo.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['opiate abuse', 'substance abuse']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The purpose of this thesis was to study an @entity74 , in @entity1 with @entity1348 ( @entity1348 ) dysfunction. The importance of @entity14884 for @entity1348 dysfunction compared with other supposed etiological factors, such as @entity89 , was analysed in @entity1348 @entity1 and in non- @entity1 groups. Collagen distribution and mitral valve function were investigated in hypermobile @entity1348 @entity1 and normal controls. General joint mobility was assessed in 360 @entity1 . Comparing 74 female @entity11158 ( @entity11158 ) @entity1 with 73 controls of the same sex and age, more hypermobile individuals were found in the @entity1 group. @entity1 with @entity1348 dysfunction had significantly more hypermobile joints than other @entity1 at a clinic for @entity11158 @entity1 . A multiple stepwise regression analysis established that @entity8018 was a more important factor than bruxing for @entity1348 dysfunction. @entity130 to the head and jaw was significantly correlated to @entity1348 dysfunction only in non-hypermobile @entity1 . @entity1348 @entity1 @entity85 than other @entity11158 @entity1 or controls. A non- @entity1 investigation comprising about 200 adolescents showed the females to be significantly more hypermobile than the males. Another indication of a systemic disposition in hypermobile @entity1348 @entity1 compared with controls was more insufficient mitral valve function in an echocardiographic investigation of 10 hypermobile @entity1348 @entity1 and 10 normal controls. Skin biopsy revealed lower values of total collagen and a higher ratio of collagen type III to III + I in @entity1348 @entity1 than in normal controls.

title: XXXX and @entity14884 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'patient']

entities_list: @entity89 :: ('MESH:D007571', 'Disease') :: ['bruxism and jaw trauma']

entities_list: @entity14884 :: ('MESH:D007593', 'Disease') :: ['systemic joint laxity']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited disposition, systemic joint laxity']

entities_list: @entity11158 :: ('MESH:D017271', 'Disease') :: ['CMD', 'craniomandibular dysfunction']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['had significantly more musculoskeletal complaints']

entities_list: @entity8018 :: ('MESH:C536196', 'Disease') :: ['hypermobility']

entities_list: @entity1348 :: ('MESH:D013706', 'Disease') :: ['TMJ', 'temporomandibular joint']

answer: @entity1348 :: (MESH:D013706,Disease) :: ['Temporomandibular joint dysfunction']


abstract: From January 1991 to May 1992 transluminal balloon valvuloplasty [correction of vulvoplasty] of severe @entity849 was performed in 14 @entity1 with Fallot's tetrad at the Institute of Cardiovascular Surgery named after A. N. Bakulev. Five of them had @entity358 , 2 had @entity850 and @entity1887 of the systemic-pulmonary @entity254 applied by the Blalock-Taussig, which made them perform balloon angioplasty of the narrowed distal portion of the @entity254 . The @entity1 ' age ranged from 11 months to 14 years (mean age 6.8 +/- 1.1 years). Arterial blood @entity26 saturation varied from 51 to 72% (mean 69.2 +/- 2.4%). The diameter of a valvular ring was 8-13 mm. The diameter of a balloon catheter exceeded that of the valvular ring by 20-25%. After dilation, arterial blood @entity26 saturation increased from 69.86 +/- 2.5 to 85.1 +/- 1.2%. The angiometry performed after pulmonary artery valvuloplasty in @entity1 with @entity358 showed an increase in sizes of all pulmonary arterial segments on an average by 22.5 +/- 4.1%. Later on 5 @entity1 were radically operated on. Thus, with the ultimate goal of preparation of @entity1 with severe Fallot's tetrad for radical surgery, transluminal balloon valvuloplasty in some @entity1 with severe @entity849 may be alternative to a systemic-pulmonary anastomosing operation.

title: [The percutaneous transluminal balloon valvuloplasty of XXXX in treating tetralogy of Fallot as an alternative to the surgery of applying a systemic-pulmonary @entity254 ].

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['hypofunction']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['valvular stenosis of the pulmonary artery']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary hypoplasia', 'pulmonary artery hypoplasia']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity849 :: (MESH:D011666,Disease) :: ['valvular stenosis of the pulmonary artery']


abstract: OBJECTIVE: To report a case of @entity1576 after a single dose of @entity1089 in an elderly @entity1 with a history of @entity1030 ( @entity1030 ). CASE SUMMARY: A 92-year-old @entity1 with a history of @entity1030 was admitted to the hospital with @entity55 . Her symptoms improved with antibiotics. Because of acute @entity2146 and @entity933 , @entity1089 50 mg twice daily was started. After receiving the first dose, the @entity1 developed @entity1576 and severe @entity149 . She required mechanical ventilation and supportive care in the intensive care unit (ICU). She had a full recovery within 24 hours. DISCUSSION: @entity1089 is an atypical antipsychotic that has been used successfully for the treatment of @entity161 and @entity162 for many years. Recently, it has also been used to treat @entity933 and @entity2146 . It has proven to be very safe, even in the elderly. In previously reported cases, serious adverse effects were seen in @entity1 who ingested very high doses of @entity1089 . Those @entity1 required intubation and supportive care in the ICU. To our knowledge, as of January 19, 2006, this is the first case report of @entity1576 of such severity with one dose of @entity1089 . Using the Naranjo probability scale, we conclude that the @entity1576 observed in this @entity1 was probably related to @entity1089 . CONCLUSIONS: This case suggests that @entity1089 can have significant adverse effects even with a single 50 mg dose. Elderly @entity1 , especially those with significant underlying @entity358 , should be monitored closely when started on this medication.

title: Acute @entity1576 with a single dose of XXXX fumarate.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['central nervous system depression']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary pathology']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['acute respiratory failure']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

entities_list: @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine', 'quetiapine fumarate', 'Quetiapine']

answer: @entity1089 :: (MESH:C069541,Chemical) :: ['quetiapine']


abstract: Comparing normal colorectal mucosa and @entity652 focusing on deregulated pathways obtains insight into the biological processes of early @entity14 . Publicly available microarray expression data from 26 normal mucosa and 47 @entity652 samples were analyzed. Biological pathways enriched in @entity652 were identified with Gene Set Enrichment Analysis (GSEA). The analysis revealed 10, 11 and 16 gene sets distinguishing @entity652 from normal mucosa according to Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Map Annotator and Pathway Profiler (GenMAPP) and Biocarta databases, respectively. Biological pathways known to be involved in @entity694 such as cell cycle (P=0.002) and Wnt signaling (P=0.007) were enriched in @entity652 . In addition, we found enrichment of novel pathways such as @entity995 ( @entity995 ) pathway (P=0.002), @entity7242 pathway (P=0.004), @entity1501 biosynthesis (P=0.019) and Hedgehog signaling (P=0.037) in @entity652 . Microarray results for @entity995 and @entity7242 pathway genes were validated by quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) on mRNA isolated from an independent set of @entity652 and normal colon samples. A high correlation between microarray data and qRT-PCR expression data was found. The relevance of targeting of identified pathways was shown using the @entity995 pathway inhibitors @entity9363 and @entity20406 and the @entity7242 pathway inhibitor @entity8947 . All inhibitors used induced cell growth reduction in @entity652 cells. This study shows a bioinformatical and functional approach leading to potentially new options for chemoprevention of @entity14 .

title: A bioinformatical and functional approach to identify novel strategies for chemoprevention of XXXX .

entities_list: @entity8947 :: ('MESH:C488369', 'Chemical') :: ['dasatinib']

entities_list: @entity9363 :: ('MESH:C104586', 'Chemical') :: ['roscovitine']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'colorectal carcinogenesis']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinogenesis']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'Rb']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: A 52-year-old Cypriot @entity1 was admitted to the surgical department of Larnaca General Hospital complaining of @entity294 and @entity158 in the right upper and lower quadrants, which was reproduced by clinical examination. A palpable mass was also felt in the region. The white blood cell count was 8420/mul: 73.9% neutrophils, 13.3% lymphocytes and 6.9% eosinophils. Erythrocyte sedimentation rate was 80 mm/h. Parasitic examination of the stools was negative. A colonoscopy located a small mass near the ileoceacal valvule, which was sent for a biopsy. A barium enema and computed tomography scan revealed the same lesion to have expanded into the ascending colon. Despite negative biopsy reports, other findings suggestive of @entity694 prompted us to perform a right hemicolectomy and ileotransverse end to side @entity254 . The mass was found to be expanding into the surrounding fat tissue and into the regional lymph notes. Surprisingly, histological examination of the mass revealed @entity9160 , owing to ascaris @entity5603 or @entity9157 .

title: An unusual case of XXXX of the ascending colon.

entities_list: @entity9157 :: ('6266', 'Species') :: ['Toxocara cati']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity5603 :: ('6265', 'Species') :: ['Toxocara canis']

entities_list: @entity9160 :: ('MESH:D007816', 'Disease') :: ['visceral larva migrans']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity5603 :: (6265,Species) :: ['Toxocara canis']


abstract: OBJECTIVE: To describe a 31-year-old female with symptomatic @entity12040 who was operated for aortic valve replacement. Although she had no preoperative @entity1504 , she died on the first postoperative day due to extensive @entity63 . METHODS: Echocardiography and computed tomography revealed progressive dilatation and thickening of the ascending aorta, severe @entity337 and diminished left ventricular function from 1998 onwards. In 2000 she was operated and a prosthesis was placed end-to-end distally of the sinutubular junction with combined reduction plasty of this junction. After the operation, in time echocardiography and computed tomography showed progressive irregularities and dilatation of the thoracoabdominal aorta and progressive @entity337 . A staged approach of aortic valve replacement and surgery for the thoracoabdominal aorta was planned. At the time of the reoperation in September 2004 the @entity32 was, after treatment with a maintenance dosage of @entity229 and imuran, in a relative quiescent phase. The aortic valve was uneventfully replaced by a mechanical valve. RESULTS: Medical treatment for @entity12040 never resulted in the @entity1 in completely normal blood values of white blood cell count, @entity1851 or erythrocyte sedimentation rate. In August 2004, she was admitted because of severe non-specific @entity158 and @entity101 . During @entity101 management, she had a short period of dipl  gia that was assumed to be due to periods of relapsed relative @entity551 . Although the computed tomography revealed severe @entity850 of the superior mesenteric artery and the celiac trunk, she was free of abdominal complaints and without further abnormal laboratory findings. One day after the aortic valve replacement a dramatic increase of transaminase and @entity880 -dehydrogenase with extreme @entity520 appeared. Urgent abdominal surgery was performed and extensive @entity63 of the liver, gallbladder, small intestine and the proximal part of the colon were found. Because of the extensive regions of @entity63 , no surgical interventions were optional. The @entity1 died one day after abdominal exploration. CONCLUSIONS: We conclude that in @entity12040 scheduled for on pump cardiac surgery, vascular workup should be done, and interventional treatment of asymptomatic but potentially critical lesions should be considered.

title: Underestimated abdominal vascular pathology in a XXXX with @entity12040 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Takayasu inflammation']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia bowel syndrome', 'ischemia']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['abdominal vascular symptoms']

entities_list: @entity12040 :: ('MESH:D013625', 'Disease') :: ['Takayasu disease']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['thoracic pain']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: This study was undertaken to quantify basic cardiac electrical field properties using the Karhounen-Loeve (K-L) numerical expansion technique after experimental @entity583 . Transmural @entity583 was produced in seven @entity235 by injection of liquid latex into the anterior descending artery; @entity583 was produced in five @entity235 by injection of the circumflex artery. Body surface potentials from 84 electrodes were recorded during sinus rhythm prior to and 1 week after @entity1188 . Electrical field properties during the QRS, ST, and QRST intervals were computed by the K-L method based upon areas calculated for each lead. The ratio of the sum of magnitude of the first three eigenvectors to the sum of all computed eigenvectors expressed as a percentage was used as a measure analogous to field dipolarity. Values before @entity1188 were high during the QRS (97.1% +/- 2.0%, mean +/- 1SD), ST (96.0% +/- 5.1%), and QRST (97.7% +/- 2.7%) intervals, with no significant difference between the three periods. After @entity1188 , the ratio during QRS decreased significantly, with lower values after posterior (61.9% +/- 11.7%) than after anterior (91.1% +/- 6.0%) @entity1188 (p less than 0.001). Values during ST and QRST intervals were not significantly changed by @entity1188 . Spatial patterns of the first eigenvector indicated that the derived QRS area electric field is directed away from the @entity296 for both anterior and posterior @entity1188 . Thus, experimental @entity583 produces significant changes in cardiac electrical field properties as measured by the K-L technique.

title: Effects of XXXX on cardiac electrical field properties using a numerical expansion technique.

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'anterior myocardial infarction', 'posterior myocardial infarction']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial lesion']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: OBJECTIVES: To compare visual outcome in response to two prescribed rates of occlusion (six hours a day and 12 hours a day). DESIGN: Unmasked randomised trial. SETTING: Research clinics in two London hospitals. @entity1 : 97 @entity1 with a confirmed diagnosis of @entity4457 associated with strabismus, @entity9340 , or both. INTERVENTIONS: 18 week period of wearing glasses (refractive adaptation) followed by occlusion prescribed ("patching") for six or 12 hours a day. MAIN OUTCOME MEASURES: Visual acuity measured by logMAR letter recognition; objectively monitored rate of occlusion (hours a day). RESULTS: The mean age of @entity1 at study entry was 5.6 (SD 1.5) years. Ninety were eligible for occlusion but 10 dropped out in this phase, leaving 80 @entity1 who were randomised to a prescribed dose rate of six (n=40) or 12 (n=40) hours a day. The mean change in visual acuity of the amblyopic eye was not significantly different (P=0.64) between the two groups (0.26 (95% confidence interval 0.21 to 0.31) log units in six hour group; 0.24 (0.19 to 0.29) log units in 12 hour group). The mean dose rates (hours a day) actually received, however, were also not significantly different (4.2 (3.7 to 4.7) in six hour group v 6.2 (5.1 to 7.3) in 12 hour group; P=0.06). The visual outcome was similar for those @entity1 who received three to six hours a day or more than six to 12 hours a day, but significantly better than that in @entity1 who received less than three hours a day. @entity1 aged under 4 required significantly less occlusion than older @entity1 . Visual outcome was not influenced by type of @entity4457 . CONCLUSIONS: Substantial (six hours a day) and maximal (12 hours a day) prescribed occlusion results in similar visual outcome. On average, the occlusion dose received in the maximal group was only 50% more than in the substantial group and in both groups was much less than that prescribed. Younger @entity1 required the least occlusion. TRIALS REGISTRATION: Clinical Trials NCT00274664.

title: Objectively monitored patching regimens for treatment of XXXX : randomised trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'PARTICIPANTS']

entities_list: @entity9340 :: ('MESH:D015858', 'Disease') :: ['anisometropia']

entities_list: @entity4457 :: ('MESH:D000550', 'Disease') :: ['amblyopia']

answer: @entity4457 :: (MESH:D000550,Disease) :: ['amblyopia']


abstract: BACKGROUND AND AIMS: @entity344 reduces food intake but the biological mechanisms explaining suppressed feeding during @entity32 are unknown. We have used a model of @entity281 ( @entity8416 in the @entity19 ) to study the effect of @entity32 on food intake, and explored the role of a key enteroendocrine cell (EEC) in the regulation of feeding by the immune response. METHODS: Food intake of NIH @entity19 infected with the intestinal @entity2199 @entity8416 was measured. Duodenal cholecystokinin ( @entity20648 ) cells were counted. Plasma @entity20648 was measured. Infected @entity19 were treated with a specific @entity19785 receptor antagonist, and food intake reassessed. The influence of the immune response on food intake and @entity20648 was mechanistically examined by treating @entity19 with @entity1961 or mast cell neutralising antibodies. The role of the T helper 2 response was further explored in @entity19 genetically deficient for @entity58 , @entity1312 , or @entity13838 (receptor alpha subunit). RESULTS: Food intake of infected @entity19 was significantly reduced at the temporal peak of @entity32 . @entity20648 expressing EEC were upregulated in infected @entity19 , and plasma @entity20648 levels were increased. A @entity19785 receptor antagonist restored the food intake of infected @entity19 to a significant degree. Furthermore, suppression of food intake was completely abolished in the absence of @entity1961 + T lymphocytes or @entity13838 . CONCLUSIONS: The data show for the first time that @entity32 results in reduced food intake due to upregulation of @entity20648 . Moreover, following infection, food intake and @entity20648 expressing cells are under the specific control of @entity1961 + T-cells, via release of @entity58 and @entity1312 .

title: Immune control of food intake: enteroendocrine cells are regulated by XXXX + T lymphocytes during small @entity32 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'intestinal inflammation']

entities_list: @entity8416 :: ('6334', 'Species') :: ['Trichinella spiralis']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['Gastrointestinal inflammation']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['upper gut infection']

answer: @entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']


abstract: Abstract Background: In TRITON-TIMI 38, @entity1 with @entity1187 were treated with @entity3076 or @entity1397 , with @entity117 , for a median of 14.5 (maximum of 15) months. Based on this trial, the EU label for @entity3076 recommends treatment for up to 12 months and excludes @entity1 with prior @entity385 ( @entity385 ). Furthermore, the EU label recommends the 10   mg @entity22 ( @entity22 ) for @entity1 with body weight >= 60   kg and age <75 years. A lower @entity22 of 5   mg is recommended for those with body weight <60   kg; although generally not recommended, 5   mg can be prescribed to @entity1 >= 75 years after individual risk-benefit evaluation. This paper presents the one-year outcome data for this '10   mg indicated cohort'. METHODS AND RESULTS: From the overall cohort of 13,608 @entity1 in TRITON-TIMI 38, 10,804 fulfilled inclusion criteria for the 10   mg indicated cohort, of whom 22% had a history of @entity6 , 73% an index diagnosis of @entity1459 /non- @entity583 (UA/NSTEMI), and 27% an index diagnosis of @entity583 ( @entity583 ). In this cohort at 12 months, those given @entity3076 experienced significantly fewer @entity63 events ( @entity65 , non-fatal @entity583 , or non-fatal @entity64 , 7.8% vs 10.5%, hazard ratio (HR)   =   0.73, p   <   0.001, than those given @entity1397 , with a non-significant increase in non-coronary artery bypass graft (CABG) TIMI major @entity548 , 1.7% vs 1.5%, HR   =   1.15, p   =   0.40; similarly, in the overall cohort these frequencies were 9.4% vs 11.4%, HR   =   0.81, p   <   0.001, for @entity65 , non-fatal @entity583 , or non-fatal @entity64 , and 2.2% vs 1.8%, HR   =   1.24, p   =   0.10, for non-CABG TIMI major @entity548 . There was a significant reduction in stent @entity715 in the @entity3076 group, with similar mortality rates and no excess of @entity64 . CONCLUSIONS: Treatment with @entity3076 according to EU label recommendations results in a significant 27% and 57% relative risk reduction (absolute risk reductions of 2.7% and 1.2%) in @entity63 events and stent @entity715 respectively compared with @entity1397 , with a 15% relative risk increase (absolute risk increase of 0.2%) for major @entity548 (p   =   0.40), and no excess of @entity64 . LIMITATIONS: Although restricted to 365 days of follow-up, this analysis encapsulates 1366 of 1424 (95.9%) of all primary endpoint events and 244 of 257 (94.9%) of all first non-CABG TIMI major @entity548 reported in the pivotal manuscript. Furthermore, the 10   mg indicated cohort was not a pre-specified subgroup in the study protocol, but due to European labeling restrictions, results for all outcomes in this cohort are presented through 12 months.

title: An analysis of TRITON-TIMI 38, based on the 12 month recommended length of therapy in the European label for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes']

entities_list: @entity3076 :: ('MESH:C408153', 'Chemical') :: ['prasugrel']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'bleeds']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['maintenance dose', 'MD']

entities_list: @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombosis']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'myocardial infarction', 'ST-segment-elevation myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['stroke/transient ischemic attack', 'TIA']

answer: @entity3076 :: (MESH:C408153,Chemical) :: ['prasugrel']


abstract: The development of an ideal aortic stent graft continues to progress. New devices and techniques are expanding the use of endovascular repair in the treatment of @entity1028 ( @entity1028 ). We present data with intraoperative composite endograft (CEG) techniques evaluating immediate and short-term compatibility of components and @entity1 outcome. Twenty-five of 66 @entity1 (38%) received intraoperative CEGs for @entity1028 treatment. A total of 50 components were used to treat type I endoleaks, prevent graft limb kinking or treat associated @entity1029 . Nine of the components were used to manage type I proximal endoleaks. Forty-one components were used at the iliac limb for distal type I endoleak, hostile iliac anatomy, or graft limb support or to treat an associated @entity1029 . Two @entity1 were left with a type I endoleaks at the iliac attachment site on completion of graft placement. With a mean follow-up of 11 months. Two of 25 @entity1 had a @entity1070 at 6 months. One @entity1 had type I endoleak at 1 year follow-up. CEGs are essential to treat endoleaks with a high technical success rate and expand the indications for treating @entity1028 . The component's short-term compatibility makes this method of stent graft placement safe.

title: Essential techniques for intraoperative composite endograft (CEG) formation in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1029 :: ('MESH:D017543', 'Disease') :: ['iliac aneurysm']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['infrarenal AAA', 'abdominal aortic aneurysms', 'AAA']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['type II endoleak']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: The strong relationship between @entity2615 and @entity1355 is well established. The analysis of lung @entity1355 burden by light and electron microscopy assisted to understand the increased incidence of @entity2615 in @entity1355 mining and consuming nations.The data on the occupational exposure to @entity1355 are important information for the purpose of compensation of @entity3675 No. 4105 ( @entity2615 ) in Germany.However, in many cases the @entity1 have forgotten conditions of @entity1355 or had no knowledge about the used materials with components of @entity1355 . Mineral fiber analysis can provide valuable information for the research of @entity66 and for the assessment of exposure. Because of the variability of @entity1355 and long latency periods, the analysis of @entity1355 lung content is a relevant method for identification of @entity66 . Also, sources of secondary exposure, so called "bystander exposition" or environmental exposure can be examined by mineral fiber analysis.Household contacts to @entity1355 are known for ten @entity1 (1987-2009) in the German @entity2615 register; these @entity1 lived together with family members working in the @entity1355 manufacturing industry.Analysis of lung tissue for @entity1355 burden offers information on the past exposure. The predominant fiber-type identified by electron microscopy in @entity1 with @entity2615 is amphibole @entity1355 (crocidolite or amosite). Latency times (mean 42.5 years) and mean age at the time of diagnose in @entity1 with @entity2615 are increasing (65.5 years). The decrease of median @entity1355 burden of the lung in @entity2615 @entity1 results in disease manifestation at a higher age.Lung dust analyses are a relevant method for the determination of causation in @entity2615 . Analysis of @entity1355 burden of the lung and of fiber type provides insights into the pathogenesis of @entity3620 . The most important causal factor for the development of @entity2615 is still @entity1355 .

title: XXXX and analysis of tissue fiber content.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3675 :: ('MESH:D009784', 'Disease') :: ['occupational disease']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['asbestos-associated diseases']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['asbestos-associated mesothelioma', 'mesothelioma']

entities_list: @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant mesothelioma']

entities_list: @entity1355 :: ('MESH:D001195', 'Disease') :: ['asbestos', 'asbestos exposure']

answer: @entity2615 :: (MESH:D008654,Disease) :: ['Mesothelioma']


abstract: OBJECTIVE: To determine the effect of pregnancy and vaginal delivery on the pelvic floor and levatorani morphology and function. METHODS: Design. Cross-sectional study. Setting. Tertiary care teaching hospital. Population. 75 primigravid @entity1 were recruited for assessment at 6 weeks postpartum compared with 25 nulliparous @entity1 . Hiatal morphology and levator ani muscle @entity155 were assessed by 4-dimensional translabial ultrasound examination. The volume achievement obtained by ultrasound was performed in supine position with empty bladder at rest, on maximum Valsalva maneuver, and on maximum pelvic floor muscle contraction. Main Outcome Measures. Hiatal diameter and area were measured at the plane of minimal hiatal dimension as defined in the midsagittal plane and Levator @entity155 was assessed. RESULTS: There were significant differences in hiatal area morphology at rest, on Valsalva maneuver and during contraction of muscles among the study groups, but there was no difference in pelvic diameter at rest, on Valsalva maneuver, and during contraction. There were 21 cases of @entity155 (42%) with no significant difference between non-progressive labor (8 cases) and Normal Vaginal Delivery (NVD) (13 cases) groups. CONCLUSIONS: The results of the present study showed that non-progressive labor is the main risk factor for pelvic @entity121 , indicating the necessity of a better management and timely cesareans in @entity1 with @entity1162 .

title: @entity1162 and levator ani XXXX .

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged second stage of labor']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle injuries']

entities_list: @entity155 :: ('MESH:D014084', 'Disease') :: ['puborectalis avulsion', 'avulsion']

answer: @entity121 :: (MESH:D009135,Disease) :: ['muscle injuries']


abstract: BACKGROUND: RNA-directed regulation of epigenetic processes has recently emerged as an important feature of @entity1 differentiation and development. Perturbation of this regulatory system in the brain may contribute to the development of @entity146 . METHODS: RNA sequencing was used to identify changes in the experience-dependent expression of long noncoding RNAs (lncRNAs) within the medial prefrontal cortex of adult @entity19 . Transcripts were validated by real-time quantitative polymerase chain reaction and a candidate lncRNA, @entity60414 , was selected for further investigation. The functional role of this @entity161 -related lncRNA was explored in vivo by antisense oligonucleotide-mediated gene knockdown in the medial prefrontal cortex, followed by behavioral training and assessment of fear-related @entity148 . Long noncoding RNA-directed epigenetic regulation of gene expression was investigated by chromatin and RNA immunoprecipitation assays. RESULTS: RNA sequencing analysis revealed changes in the expression of a significant number of genes related to neural plasticity and stress, as well as the dynamic regulation of lncRNAs. In particular, we detected a significant downregulation of @entity60414 lncRNA. Our results revealed that @entity60414 plays a role in mediating @entity148 -like behavior and suggest that this may occur through an interaction with a key member of the polycomb repressive complex 1, @entity23250 , which regulates the expression of the @entity161 -related gene beta crystallin ( @entity60415 ). We also demonstrated a novel role for @entity60415 in mediating fear-induced @entity148 -like behavior. CONCLUSIONS: Experience-dependent expression of lncRNAs plays an important role in the epigenetic regulation of adaptive behavior, and the perturbation of @entity60414 may be related to @entity148 and the development of @entity146 .

title: Long Noncoding RNA-Directed Epigenetic Regulation of Gene Expression Is Associated with XXXX -like Behavior in @entity19 .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety']


abstract: OBJECTIVES: The purpose of this study was to investigate the ability of sonography to identify @entity697 in the emergency department. METHODS: Fifteen @entity1 with a final diagnosis of @entity697 from indirect laryngoscopy by an otolaryngologist were enrolled in the study. To compare the normal @entity2582 and @entity697 , 15 healthy volunteers were assigned to a control group. The sonographic appearances of the @entity5847 and the pre-epiglottic space were recorded. The anteroposterior diameter of the @entity2582 at the midpoint and both edges in a transverse view was measured in all @entity1 . RESULTS: A statistically significant difference (P < .001) was observed in the anteroposterior diameter of the @entity2582 at the midpoint and both lateral edges between the @entity1 and healthy volunteers. However, there was overlap in the ranges for the midpoint but no overlap in both lateral edges between groups. The upper-limit value for the healthy control group was 3.2 mm at both lateral edges, whereas the cutoff values of the right and left edges were 3.7 and 3.6 mm, respectively, according to the lower-limit value for the @entity5847 group. CONCLUSIONS: The anteroposterior diameter of the @entity2582 was significantly different between the @entity1 with @entity5847 and the healthy volunteers. Because of this significant difference in the anteroposterior diameter of the @entity2582 , sonography can be used as a rapid, noninvasive, and effective diagnostic tool for identifying cases of @entity5847 in the emergency department.

title: Use of bedside sonography for diagnosing XXXX in the emergency department: a preliminary study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute epiglottitis']

entities_list: @entity5847 :: ('MESH:D004826', 'Disease') :: ['epiglottitis']

entities_list: @entity2582 :: ('MESH:C537690', 'Disease') :: ['epiglottis']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute epiglottitis']


abstract: This paper evaluates the hearing status in the long-term, of @entity1 who have had radiotherapy for @entity189 ( @entity189 ) and also discusses the @entity393 from a disability point of view, which takes into account binaural hearing. Forty @entity1 who have had @entity189 successfully treated by a single radical course of radiotherapy of 70-80 Gy were studied at 2-12 years (mean 6.2 years) after radiotherapy. Each @entity1 was examined clinically and with a pure-tone audiogram. Averaged hearing thresholds over 0.5, 1.0, 2.0 and 4.0 kHz were evaluated and a value > 30 dB was considered abnormal. The findings were compared with age-matched controls. The median hearing threshold for each ear in @entity189 @entity1 was found to be 31.9 dB (range 10.0-86.3 dB) and that for controls 17.5 dB (7.5-38.8 dB) (P < 0.0005, Wilcoxon's matched pairs test). In @entity189 @entity1 , 44 ears (55.0%) had abnormal hearing, of which 17 (21.3%), 5 (6.3%) and 22 (27.5%) ears had predominantly sensori-neural, conductive and mixed @entity393 , respectively. Nineteen ears had @entity2171 , accounting for the majority of mixed and conductive @entity393 . In terms of individual @entity1 , 8 (20.0%) and 18 (45.0%) @entity1 had abnormal hearing in one year (monaural @entity393 ) and both ears ( @entity393 ), respectively. In conclusion, a substantial proportion of @entity1 who have had radiotherapy for @entity189 , have @entity393 in the long-term, as compared to normal controls.

title: Long-term hearing status after radiotherapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2171 :: ('MESH:D010034', 'Disease') :: ['middle ear effusions']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing disability', 'binaural hearing disability', 'hearing losses']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC']

answer: @entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']


abstract: OBJECTIVE: Hemorrhagic transformation of @entity385 (HTI) occurs spontaneously but its frequency and risk factors are uncertain with mixed results in previous studies. We aimed to determine the overall frequency of and risk factors for HTI. METHODS: We performed a systematic review according to Cochrane Collaboration methods of published reports of HTI with reliable, systematic follow-up with computed tomography or magnetic resonance imaging. RESULTS: In all, 28 observational studies and 19 randomized controlled trials in @entity64 were identified that included follow-up imaging data. Problems with inconsistent definitions or small and biased @entity1 populations limited detailed interpretation. The overall frequency of any HTI in untreated @entity1 was 8.5% (95% confidence interval 7%-10%). Severe HTI (i.e., HTI accompanied by @entity16 or parenchymal @entity1410 formation) occurred in 1.5% (95% confidence interval 0.8%-2.2%). The frequency of HTI increased markedly with increasing use of antithrombotic or thrombolytic drugs. Magnetic resonance imaging detected more HTI than did computed tomography. The published data were generally inadequate to undertake more detailed analysis of risk factors. However, in the 8 studies that did provide the information, HTI was associated with large @entity1188 , mass effect, @entity6152 observed early after the @entity64 , and age older than 70 years, but not @entity101 or @entity64 . CONCLUSIONS: Severe HTI is uncommon in @entity1 not receiving antithrombotic or thrombolytic agents. The methods used to assess the frequency of and risk factors for HTI, particularly a standard of definitions in future prospective studies, could be improved.

title: Frequency and risk factors for spontaneous XXXX .

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['cardioembolic stroke', 'stroke']

entities_list: @entity6152 :: ('MESH:C565408', 'Disease') :: ['hypodensity']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic deterioration']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity385 :: (MESH:D002544,Disease) :: ['hemorrhagic transformation of cerebral infarction']


abstract: Helicases are ubiquitous molecular motor proteins that play important role in maintaining the genome integrity and thus involved in plant growth and development. Here, we report the cloning of cDNA (1.64 kb) and genomic DNA (2.2 kb) of cold stress-induced @entity3587 DNA helicase 47 (PDH47) and characterization of its encoded protein. It belongs to DEAD-box protein family and shows striking identity (93%) with @entity286 eIF4A. The transcript was induced under cold (4 degrees C) stress. The purified PDH47 protein (47 kDa) contains @entity855 -/ @entity1025 -dependent DNA unwinding as well as DNA-/ @entity1025 -dependent ATPase activities. The ATPase activity of PDH47 is stimulated more by ssDNA as compared to dsDNA and RNA. The activities of PDH47 are inhibited by various DNA-interacting ligands such as @entity57942 , @entity5699 , @entity5611 , @entity2664 , @entity4316 , and @entity900 with apparent Ki values ranging from 0.5 to 8.0 microM. Interestingly, netropsin and @entity38140 inhibited the helicase but not the ATPase activity. The inhibition might be due to the intercalation of inhibitors into duplex DNA, which can impede the translocation of the PDH47. This study should help in our better understanding of cold stress signaling and mechanism of DNA unwinding in plants.

title: Cold stress-induced XXXX DNA helicase 47 is homologous to eIF4A and inhibited by DNA-interacting ligands.

entities_list: @entity5699 :: ('MESH:D003630', 'Chemical') :: ['daunorubicin']

entities_list: @entity5611 :: ('MESH:D004996', 'Chemical') :: ['ethidium bromide']

entities_list: @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity4316 :: ('MESH:D003609', 'Chemical') :: ['actinomycin']

entities_list: @entity38140 :: ('MESH:C030000', 'Chemical') :: ['distamycin']

entities_list: @entity57942 :: ('MESH:D009621', 'Chemical') :: ['nogalamycin']

answer: @entity3587 :: (3888,Species) :: ['pea']


abstract: AIM: Contribution of 3-phase @entity9242 PET/CT in suspected @entity263 recurrence at early rise of PSA. @entity1 , METHODS: Retrospective analysis was performed in 47 @entity1 after initial treatment with radiotherapy (n=30) or surgery (n=17). Following CT, 10 minutes list-mode PET acquisition was done over the prostate bed after injection of 300 MBq of @entity9242 . Three timeframes of 3 minutes each were reconstructed for analysis. All @entity1 underwent subsequent whole body PET/CT. Delayed pelvic PET/CT was obtained in 36 @entity1 . PET/CT was interpreted visually by two observers and SUVmax determined for suspicious lesions. Biopsies were obtained from 13 @entity1 . RESULTS: Biopsies confirmed the presence of @entity5 in 11 of 13 @entity1 with positive PET for a total of 15 local recurrences in which average SUVmax increased during 14 minutes post injection and marginally decreased in delayed scanning. Conversely inguinal lymph nodes with mild to moderate metabolic activity on PET showed a clearly different pattern with decreasing SUVmax on dynamic images. Three-phase PET/CT contributed to the diagnostic assessment of 10 of 47 @entity1 with biological evidence of recurrence of @entity5 . It notably allowed the discrimination of confounding blood pool or urinary activity from suspicious hyperactivities. PET/CT was positive in all @entity1 with PSA>or=2 ng/ml (n=34) and in 4/13 @entity1 presenting PSA values<2 ng/ml. CONCLUSION: @entity9242 3-phase PET/CT showed a progressively increasing SUVmax in biopsy confirmed @entity5 up to 14 minutes post injection while decreasing in inguinal lymph nodes interpreted as benign. Furthermore, it was very useful in differentiating local recurrences from confounding blood pool and urinary activity.

title: Three-phase @entity9242 PET/CT in the evaluation of XXXX recurrence.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cancer lesions']

entities_list: @entity9242 :: ('MESH:C514960', 'Chemical') :: ['18F-fluorocholine']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: @entity1031 events are an increasingly commonly recognized secondary complications in @entity1 treated for serious, life-threatening primary diseases. Nevertheless the incidence of @entity1211 remains 100 times less frequent in hospitalized @entity1 than hospitalized adults, as recent data suggest an incidence of 5,3/10.000 pediatric @entity1 compared to an incidence of 2,5-5/100 in adult @entity1 . Diseases usually associated with @entity1031 in @entity1 are @entity5 , autoimmune or @entity299 . Contrarily to what is observed in the adult, the majority of @entity1150 events occur at the upper limbs veins, usually at the place where devices for venous access like port-a-cath or central venous lines are inserted. Because of the relatively low incidence of venous @entity1031 in @entity1 , the diagnostic approach used are largely extrapolated from guidelines obtained from adult studies. However, the diagnostic performances of some diagnostic tools like Doppler-Ultrasound are probably diminished in @entity1 . Moreover, the concept of developmental hemostasis, which stresses the point that the hemostatic system in @entity1 is quite different from the adult one, is widely accepted and clearly suggests that the diagnostic and therapeutic approach in pediatric @entity1 may not be simply extrapolated from data obtained in adult studies. From a more practical point of view, the fact that the hemostatic system in @entity1 is a dynamic and evolving system, renders the therapeutic approach quite complex. In particular, doses of anticoagulants vary markedly across the pediatric age. The absence of adapted formulations of commonly used anticoagulants, for example the absence of liquid formulations of anti- @entity2067 drugs, further complicates the administration and the correct monitoring of anticoagulation in @entity1 , and may diminish observance in adolescent @entity1 . Even though the concept that " @entity1 are not little adults" is nowadays widely accepted, there is an urgent need for prospective studies to better assess the modalities of diagnosis and treatment of @entity1211 in this particular population.

title: [Diagnosis and treatment of XXXX in pediatrics].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['Thromboembolic', 'thromboembolic events']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac malformative disease']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolic disease']

answer: @entity1031 :: (MESH:D013923,Disease) :: ['thromboembolic events']


abstract: BACKGROUND: The differences in outcome among @entity5 @entity1 with incidental vs. symptomatic @entity1211 ( @entity1211 ) are unknown. In this study, @entity1 with extrahepatic @entity5 ( @entity5 ) were selected for a prospective cohort study between February 2008 and February 2011. METHODS: At the time of @entity5 diagnosis, all @entity1 were examined for @entity1150 with bilateral compression ultrasonography (biCUS). Computed tomography pulmonary angiography was also performed to diagnose @entity1151 . After inclusion, the @entity1 were followed up with clinical examinations, blood collections, and biCUS. RESULTS: A total of 121 @entity5 @entity1 were enrolled. At the time of @entity5 diagnosis, 15 @entity1 had experienced a @entity1211 (12.4%, 95% confidence interval [CI]  7.1-19.6), including six symptomatic and nine incidental cases. A total of 25 first-time @entity1211 events were identified (20.7%; 95%  CI  13.8-29.0). @entity1 with a @entity1211 had reduced survival, with a median overall survival (OS) of 4.4  months (95%  CI  2.2-11.5). The median OS of the @entity1 with incidental @entity1211 was 3.0  months (95%  CI  0.1-15.0), which was not different from the median OS of the @entity1 with symptomatic @entity1211 (5.0  months; 95%  CI  2.1-14.5). The median OS was 11.9  months (95%  CI  8.1-14.7) in the @entity5 @entity1 with no VTEs. CONCLUSION: The occurrence of a @entity1211 event in a @entity5 @entity1 within the first months of the disease is associated with significantly increased mortality.

title: Venous thrombosis in XXXX : outcome and prognostic factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['PBC', 'pancreaticobiliary tract cancer', 'cancer']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolisms']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism']

answer: @entity5 :: (MESH:D009369,Disease) :: ['pancreaticobiliary tract cancer']


abstract: We have cloned and analyzed the @entity2199 regulatory myosin light-chain genes. @entity2199 contains two such genes, which we have designated @entity57470 and @entity57471 . The two genes are separated by 2.6 kilobases and are divergently transcribed. We determined the complete @entity377 sequences of both @entity57470 and @entity57471 . A single, conservative @entity535 substitution distinguishes the sequences of the two proteins. The @entity2199 proteins are strongly homologous to regulatory myosin light chains of @entity238 and vertebrates and weakly homologous to a superfamily of eucaryotic @entity460 -binding proteins. Both @entity57470 and @entity57471 encode abundant mRNAs. We mapped the 5' termini of these transcripts by using primer extension sequencing of mRNA templates. @entity57470 mRNAs initiate within conserved hexanucleotides at two different positions, located at -28 and -38 relative to the start of translation. The 5' terminus of @entity57471 mRNA is not encoded in the 4.8-kilobase genomic region upstream of @entity57471 . Rather, @entity57471 mRNA contains at its 5' end a short, untranslated leader sequence that is identical to the trans-spliced leader sequence of three @entity2199 actin genes.

title: Regulatory myosin light-chain genes of XXXX .

entities_list: @entity2199 :: ('6239', 'Species') :: ['C. elegans', 'Caenorhabditis elegans']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila melanogaster']

answer: @entity2199 :: (6239,Species) :: ['Caenorhabditis elegans']


abstract: AIMS: Assessment of @entity1 with suspected @entity583 ( @entity583 ) is based on cardiac troponin (cTn) levels with the 99th percentile as cut-off. However, @entity65 starts already at lower troponin concentrations. We therefore, aimed to investigate the utility of 2-hour algorithms using the high-sensitivity cardiac troponin I (hs- @entity6949 ) 97.5th percentile as cut-off which corresponds to the standard URL for most biomarkers. METHODS: Hs- @entity6949 was measured at presentation and 2h in 1624 @entity662 @entity1 . @entity3129 were developed applying hs- @entity6949 levels dichotomized at the 99th and 97.5th percentiles combined with hs- @entity6949 changes and/or ECG findings. RESULTS: The prevalence of @entity583 was 13.9%. The adjusted odds ratios for 1-year mortality were 2.7 (95% CI 1.4-5.1) for the 99th percentile and 3.1 (95% CI 1.6-5.9) for the 97.5th percentile. The best-performing 99th percentile-based algorithms provided a positive predictive value ( @entity2286 ) of 86.3% and a negative predictive value (NPV) of 99.3%. Using 97.5th percentile-based algorithms to define @entity583 resulted in few reclassifications and yielded similar diagnostic estimates ( @entity2286 85.4%, NPV 99.4%). CONCLUSION: The hs- @entity6949 97.5th percentile integrated into 2-hour algorithms provided high diagnostic estimates and could, due to better prognostic properties serve as an alternative to the 99th percentile.

title: Two-hour diagnostic algorithms for early assessment of XXXX with acute @entity662 --Implications of lowering the cardiac troponin I cut-off to the 97.5th percentile.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity3129 :: ('MESH:D005119', 'Disease') :: ['Diagnostic algorithms']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['NSTEMI', 'non-ST elevation myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular risk']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND OBJECTIVE: To evaluate the effect of oral @entity14292 on subretinal fluid, visual acuity, and @entity3193 in @entity1 with @entity989 (CSCR). @entity1 AND METHODS: Retrospective review of all @entity1 (14 eyes of 14 @entity1 ) monitored for a minimum of 3 months with chronic CSCR who were treated with oral @entity14292 in a single multi-physician retina practice. Visual acuity, dilated funduscopic examination, and spectral-domain ocular coherence tomography (OCT) with enhanced depth imaging (EDI) were obtained at each visit. Measurement of subfoveal fluid (SFF) height and @entity3193 were performed. Two-tailed paired t test was used to calculate statistical significance of pre- and post-treatment variables. RESULTS: At 1 month, 10 of 14 eyes had decreased SFF height on OCT and two eyes had complete resolution of SFF. Mean SFF height decreased from 13 0  m to 62   m (P = .05). Mean @entity3193 decreased from 315   m to 282   m (P = .07). Mean visual acuity improved from logMAR 0.41 to 0.40. At 3 months, 13 of 14 (93%) had decreased SFF on OCT, and nine eyes (64%) had complete resolution of SFF. Mean SFF height decreased to 21   m (P = .004). Mean @entity3193 decreased to 253   m (P = .10). Mean visual acuity improved to logMAR 0.28 (P = .02). CONCLUSION: Oral @entity14292 may be effective in treating @entity1 with chronic CSCR. [Ophthalmic Surg Lasers Imaging Retina. 2015;46:439-444.].

title: Oral @entity14292 for treatment of XXXX : a case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity14292 :: ('MESH:C414690', 'Chemical') :: ['eplerenone']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['chronic central serous chorioretinopathy']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal thickness']

answer: @entity989 :: (MESH:D012164,Disease) :: ['chronic central serous chorioretinopathy']


abstract: OBJECTIVE: The purpose of this study was to observe tooth eruption pattern into the newly generated bone induced by recombinant @entity1 @entity1841 (rhBMP-2). METHOD: Three 12-week-old @entity235 were used. Following wound healing of the extracted maxillary third deciduous incisor at the age of 13 weeks, a resection of @entity604 (8 mm by 8 mm by 8 mm) was carried out, accompanied by extraction of the maxillary second incisor tooth germ. The rhBMP-2 (5 microgram/100 microL or 10 microgram/100 microL) was implanted in the resected area. A group that was not implanted after resection and a nonresected group were used as controls. Serial changes of the eruption pattern of the maxillary third incisor in the implanted area were observed radiographically. @entity5385 and @entity5384 were employed as bone markers. Nine weeks after the implantation, the animals were sacrificed. The samples were observed histologically and analyzed using peripheral quantitative computerized tomography to acquire the @entity79 ( @entity79 ). RESULTS: In the rhBMP-2 (5 microgram/100 microL)-treated group, histological findings and the @entity79 of the newly generated bone were almost same as in the nonresected group. The maxillary third incisor erupted through the implanted area. However, in the rhBMP-2 (10 microgram/100 microL)-treated group, more osteoinductive activity and significantly higher @entity79 were observed in the newly generated bone. The maxillary third incisor erupted mesially so as to avoid this implanted area. CONCLUSION: Results showed that bone remodeling and tooth eruption through the newly generated bone appear to be dose dependent. Accordingly, proper dosage of rhBMP-2 should be determined for successful clinical application.

title: Tooth eruption into the newly generated bone induced by recombinant XXXX @entity1841 .

entities_list: @entity1841 :: ('650', 'Gene') :: ['bone morphogenetic protein-2']

entities_list: @entity235 :: ('9615', 'Species') :: ['beagle dogs']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['maxillary alveolar bone']

entities_list: @entity5385 :: ('MESH:D010118', 'Chemical') :: ['Oxytetracycline']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Between 1992 and 1996, 73 acute humeral shaft @entity174 in 71 @entity1 were treated with antegrade Russell-Taylor humeral nailing. Sixty (84%) @entity1 sustained @entity1230 , and 26 (36%) @entity174 were open. Three @entity1 had preoperative @entity1317 , and 12 had @entity129 . Sixty-nine (94.5%) @entity174 united primarily, and two additional @entity174 united after bone grafting. There were no infections. Two (2.7%) iatrogenic @entity4542 occurred, and both were transient. Full shoulder function returned in 66 (90%) @entity1 . Two (2.7%) @entity1 had impingement from proximal locking screws, and one (1.4%) had impingement from a prominent nail. Normal elbow function was regained in 96% of @entity1 . All @entity1 without full return of elbow and shoulder function had concomitant injuries. Antegrade Russell-Taylor nailing is an acceptable alternative for the treatment of acute humeral shaft @entity174 in multiply injured @entity1 .

title: Antegrade interlocking nailing of acute humeral shaft XXXX .

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['preoperative nerve palsies']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple trauma']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['brachial artery injuries']

entities_list: @entity4542 :: ('MESH:D020425', 'Disease') :: ['radial nerve palsies']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: Forty-four @entity249 @entity1 with the @entity3610 ( @entity3610 ) resistant to other treatment modalities were treated in 58 cycles of IVF after accomplishment of pituitary gonadotroph suppression with a GnRH-agonist. Four cycles were cancelled before oocyte retrieval while embryo transfer was deferred for 10 cycles due to imminent @entity43 ( @entity43 ). Follicle aspiration yielded 18.8 +/- 9 oocytes per cycle. The cleavage rate was 68%. There was no cleavage in five cycles. The pregnancy rate was 33.3% per embryo transfer. In 32 cycles 9.0 +/- 5 suitable supernumerary embryos were cryopreserved. Transfer of cryopreserved embryos gave three additional pregnancies. The accumulated pregnancy rate per @entity1 was 36%. In @entity4082 resistant @entity1 , transfer of cryopreserved embryos was accomplished after secretory transformation of the endometrium by @entity53 / @entity1420 substitution. Although seven pregnancies ended in a miscarriage, the 'take-home' baby rate was 20%. @entity43 ensued in 28 (46.7%) cycles. In @entity3610 , in-vitro fertilization following pituitary gonadotroph suppression seems a treatment alternative with pregnancy rates comparable to normo-ovulatory @entity1 with @entity249 . However, the incidence of @entity43 is high and constitutes the major problem of cycle control.

title: In-vitro fertilization in XXXX @entity1 with the @entity3610 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian hyperstimulation syndrome', 'OHSS']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['tubal factor infertility', 'infertile']

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovarian syndrome', 'PCOS']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene citrate']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertile']


abstract: In @entity1568 -limiting conditions, approximately 10% of the vegetative cells in filaments of the cyanobacterium Anabaena ( @entity13931 differentiate into @entity1568 -fixing heterocysts. During the late stages of heterocyst differentiation, three DNA elements, each embedded within an open reading frame, are programmed to excise from the chromosome by site-specific recombination. The DNA elements are named after the genes that they interrupt: nifD, fdxN, and hupL. The nifD and fdxN elements each contain a gene, xisA or xisF, respectively, that encodes the site-specific recombinase required for programmed excision of the element. Here, we show that the xisC gene (alr0677), which is present at one end of the 9,435-bp hupL element, is required for excision of the hupL element. A strain in which the xisC gene was inactivated showed no detectable excision of the hupL element. hupL encodes the large subunit of uptake hydrogenase. The xisC mutant forms heterocysts and grows diazotrophically, but unlike the wild type, it evolved @entity3884 gas under @entity1568 -fixing conditions. Overexpression of xisC from a plasmid in a wild-type background caused a low level of hupL rearrangement even in @entity1568 -replete conditions. Expression of xisC in @entity526 was sufficient to produce rearrangement of an artificial substrate plasmid bearing the hupL element recombination sites. Sequence analysis indicated that XisC is a divergent member of the phage integrase family of recombinases. Site-directed mutagenesis of xisC showed that the XisC recombinase has functional similarity to the phage integrase family.

title: Heterocyst-specific excision of the XXXX hupL element requires xisC.

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity3884 :: ('MESH:D006859', 'Chemical') :: ['hydrogen']

answer: @entity13931 :: (103690,Species) :: ['Anabaena sp. strain PCC 7120']


abstract: The glycoproteins of @entity3597 , grown in @entity1573 embryo cells, were labeled with radioactive @entity3363 . The data indicate a high @entity3913 content of the nonstructural precursor glycoprotein NSP 63. This protein can also be readily labeled with @entity897 . The envelope glycoproteins @entity4803 are relatively rich in @entity3649 , @entity4823 , and @entity3953 . Glycosylation can be impaired by @entity897 or @entity46468 or by omission of @entity3363 in the culture medium. Under these conditions characteristic changes in the electrophoretic profile of the viral polypeptides are observed: in the regions of glycoproteins NSP 97, NSP 63, and @entity4803 new protein peaks can be detected. These polypeptides seem to be aberrant forms of the glycoproteins. When compared with the normal molecules they have lower molecular weights and contain less @entity3363 , especially @entity3913 . Pulse-chase experiments indicate that the altered glycoproteins are degraded very slowly if at all. If, however, impairment is caused by omission of @entity3363 in the culture medium, the radioactivity is chased after addition of @entity413 from the region between NSP 63 and E1 + E2 into the E1 + E2 peak. This suggests a completion of the @entity1735 chains under these conditions.

title: Effect of impaired glycosylation on the biosynthesis of XXXX glycoproteins.

entities_list: @entity46468 :: ('CHEBI:28393', 'Chemical') :: ['D-glucosamine']

entities_list: @entity4823 :: ('MESH:D005944', 'Chemical') :: ['glucosamine']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity3649 :: ('MESH:D005690', 'Chemical') :: ['galactose']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity3597 :: ('11033', 'Species') :: ['Semliki Forest virus']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['sugars', 'carbohydrates']

entities_list: @entity897 :: ('MESH:D003847', 'Chemical') :: ['2-deoxy-D-glucose']

answer: @entity3597 :: (11033,Species) :: ['Semliki forest virus']


abstract: STUDY OBJECTIVES: To compare the accuracy of virtual bronchoscopy (VB) with fiberoptic bronchoscopy (FOB) and pulmonary function testing (PFT) for the assessment of @entity6184 and @entity850 . DESIGN: Prospective case series. SETTING: Pulmonary institute of major tertiary university-affiliated center. @entity1 : The study group included 10 lung transplant recipients and 13 @entity1 with central airway stenosis. INTERVENTIONS: All @entity1 underwent PFT, VB, and FOB. All cases were graded by each modality on a scale of 1 to 3, and the findings were compared between modalities. RESULTS: Mean +/- SD stenosis score was 2.0 +/- 0.79 for PFT, 1.62 +/- 0.73 for FOB, and 1.82 +/- 0.77 for VB. A statistically significant correlation was found between VB and FOB scores (p < 0.0001, r = 0.76) and between VB scores and PFT (p = 0.03, r = 0.45). There was no correlation between PFT and FOB. CONCLUSIONS: VB grading of @entity19926 is well correlated with PFT. VB may be used to evaluate @entity1 with known @entity19926 after treatment and thereby reduce the frequency of repeated invasive FOB performed for that purpose. The correlation of VB with @entity15795 may improve the reliability of this approach.

title: Accuracy of virtual bronchoscopy for grading XXXX : correlation with pulmonary function test and fiberoptic bronchoscopy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity19926 :: ('MESH:C566362', 'Disease') :: ['tracheobronchial stenosis']

entities_list: @entity6184 :: ('MESH:D014135', 'Disease') :: ['tracheal stenosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['bronchial anastomotic stenosis']

answer: @entity19926 :: (MESH:C566362,Disease) :: ['tracheobronchial stenosis']


abstract: A case of @entity10053 cerebri in a 27-year-old @entity1 showing various cranial nerve manifestations is described. He was diagnosed as having @entity4216 multiplex (bilateral oculomotor nerve @entity912 , left @entity3541 , @entity10296 manifestations, and @entity2895 ) and was hospitalized in the neurology department on August 1, 2000. Although he continued to visit the neurology department after discharge, his manifestations showed no improvement. He was sent to our department for brain biopsy in August 2001. A biopsy performed at the Sylvian fissure from the frontal lobe/temporal lobe cortex showed high intensity on T2-weighted and Flair magnetic resonance imaging (MRI). The pathological findings were diffuse low-grade @entity816 infiltrating between the pia mater and the cerebral cortex. We believed that the @entity816 spreading on the subpia mater was responsible for the various cranial nerve manifestations, and we started whole-brain irradiation (46 Gy) + @entity2391 D.I.V. from September 2001. The pathological findings of the brain biopsy showed @entity816 . The clinical presentation was dramatically improved after radiotherapy. It seemed that this @entity5 had spread along the subpia mater and subependyma. When he was discharged in early December, he walked by himself. The characteristic features of this case are that no lesion in the cerebellum or brain stem was found on MRI, even though the main manifestations were cerebello-brain stem manifestations, and biopsy of the cerebral cortex revealed @entity816 . It should be noted that the clinical manifestations of @entity816 in some cases are dissociated from the imaging observations.

title: XXXX cerebri in a young @entity1 showing various cranial nerve manifestations: a case report.

entities_list: @entity10296 :: ('MESH:D010244', 'Disease') :: ['bulbar palsy']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['hypoglossal nerve paralysis']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['diffuse astrocytoma', 'astrocytoma']

entities_list: @entity10053 :: ('MESH:D018302', 'Disease') :: ['gliomatosis']

entities_list: @entity4216 :: ('MESH:D020422', 'Disease') :: ['cranial mononeuritis']

entities_list: @entity2391 :: ('3456', 'Gene') :: ['interferon (IFN)-beta']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial nerve paralysis']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']

answer: @entity10053 :: (MESH:D018302,Disease) :: ['Gliomatosis']


abstract: The present study tested whether a gene-transfer based upon the retrograde axonal transport of the lacZ adenovirus is effective in the spinal descending tracts of the adult @entity19 . A small volume of a replication-defective recombinant adenovirus encoding @entity526 @entity7791 was injected into the upper lumbar cord, and, seven days later, the @entity19 were transcardially perfused by a fixative solution. X-gal staining of coronal or sagittal sections of the spinal cord and the brain revealed that many sites of origin for rubrospinal, vestibulospinal, and reticulospinal tracts were retrogradely labeled, whereas few of the corticospinal tract neurons were retrogradely labeled. Ependymal cells surrounding the central canal of the spinal cord, which were located far from the injection site, showed a high expression of @entity7791 activity. Motoneurons around the injection site were strongly stained by X-gal staining, and their axons in the ventral root were anterogradely labeled. Afferent fibers in the dorsal root were labeled by the transganglionic transport of @entity7791 . To examine the efficacy of the uptake and retrograde transport of HRP and adenovirus, we injected a mixed solution of 10% HRP and recombinant adenovirus. The number of HRP-labeled corticospinal neurons overwhelmed the number of X-gal stained ones, while the numbers of HRP-labeled rubrospinal and subcoeruleus-spinal neurons were smaller in comparison with the numbers of @entity7791 -positive counterparts. The present study revealed that the origins for the spinal descending tracts except for corticospinal neurons could be efficiently gene-transferred by the @entity281 of a recombinant adenovirus. Such a difference in efficacy of @entity281 among the spinal descending tracts is practically important when an adenovirus-mediated gene transfer is designed to treat certain @entity16 affecting the spinal descending tracts.

title: Retrograde labeling of XXXX spinal descending tracts by a recombinant adenovirus.

entities_list: @entity7791 :: ('MESH:D016537', 'Disease') :: ['beta-galactosidase']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['retrograde infection']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: OBJECTIVE: To quantitatively evaluate blood-brain barrier changes in @entity385 @entity1 using dynamic contrast-enhanced (DCE) MRI. METHODS: We examined 54 @entity64 @entity1 (clinicaltrials.gov NCT00715533, NCT02077582) in a 3T MRI scanner within 48 hours after symptom onset. Twenty-eight @entity1 had a follow-up examination on day 5-7. DCE T1 mapping and Patlak analysis were employed to assess BBB permeability changes. RESULTS: Median @entity64 K(trans) values (0.7 * 10(-3) @entity1009 ) [interquartile range (IQR) 0.4-1.8] * 10(-3) @entity1009 )) were more than 3-fold higher compared to median mirror K(trans) values (0.2 * 10(-3) @entity1009 ), IQR 0.1-0.7 * 10(-3) @entity1009 ), p < 0.001) and further increased at follow-up (n = 28, 2.3 * 10(-3) @entity1009 ), IQR 0.8-4.6 * 10(-3) @entity1009 ), p < 0.001). By contrast, mirror K(trans) values decreased over time with a clear interaction of timepoint and @entity64 /mirror side (p < 0.001). Median @entity64 K(trans) values were 2.5 times lower than in hemorrhagic transformed regions (0.7 vs 1.8 * 10(-3) @entity1009 ); p = 0.055). There was no association between @entity64 K(trans) values and the delay from symptom onset to baseline examination, age, and presence of hyperintense acute reperfusion marker. CONCLUSION: BBB in @entity64 @entity1 can be successfully assessed quantitatively. The decrease of BBB permeability in unaffected regions at follow-up may be an indicator of global BBB leakage even in vessel territories remote from the index @entity1188 .

title: DCE-MRI blood-brain barrier assessment in acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'acute stroke']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']