abstract: BACKGROUND: Systems of functional electrical stimulation (FES) have been demonstrated to enable some @entity1 with @entity451 to stand and ambulate limited distances. However, the energy costs and acute physiologic responses associated with FES standing activities have not been well investigated. OBJECTIVE: To compare the physiologic responses of @entity1 with @entity451 to active @entity177 ( @entity177 ) and frame-supported passive standing (PS). METHODS: Fifteen @entity1 with @entity451 (T6-T11) previously habituated to FES ambulation, completed physiologic testing of PS and @entity177 . The @entity177 assessments were performed using a commercial FES system (Parastep-1; Altimed, Fresno, @entity2948 ); the PS tests used a commercial standing frame (Easy Stand 5000; Altimed, Fresno, @entity2948 ). @entity1 also performed a peak arm-cranking exercise (ACE) test using a progressive graded protocol in 3-minute stages and 10-watt power output increments to exhaustion. During all assessments, metabolic activity and heart rate (HR) were measured via open-circuit spirometry and 12-lead electrocardiography, respectively. Absolute physiologic responses to PS and @entity177 were averaged over 1-minute periods at 5-minute intervals (5, 10, 15, 20, 25, and 30 minutes) and adjusted relative to peak values displayed during ACE to determine percentage of peak (%pk) values. Absolute and relative responses were compared between test conditions ( @entity177 and PS) and across time using two-way analysis of variance. RESULTS: The @entity177 produced significantly greater values of @entity4962 (43%pk) than did PS (20%pk). The mean HR responses to PS (100-102 beats per minute [bpm] throughout) were significantly lower than during @entity177 , which ranged from 108 bpm at 5 minutes to 132 bpm at test termination. CONCLUSION: Standing with FES requires significantly more energy than does @entity177 and may provide a cardiorespiratory stress sufficient to meet minimal requirements for exercise conditioning.

title: Physiologic responses to electrically assisted and frame-supported standing in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'persons']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['AS', 'FES-assisted standing']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['paraplegia']

answer: @entity451 :: (MESH:C536857,Disease) :: ['paraplegia']


abstract: In total, 189 consecutive @entity1 diagnosed with @entity1252 were evaluated using the ACR 1990 criteria for @entity239 . @entity1 were classified into three subgroups. The @entity239 group (FM) included @entity1 experiencing @entity158 on palpation in at least 11 of the 18 tender points examined, as well as having a history of @entity158 for at least three months. @entity1 who were noted to have @entity158 in fewer than four quadrants with less than 11 of 18 tender points were considered to have @entity158 ( @entity158 ). All @entity1 who did not meet criteria for either FM or @entity158 were classified as having no @entity158 (NP). Measurement of @entity1252 disease activity, sleep complaints, @entity308 , @entity1295 severity and health status were performed. Only 18 of the @entity1252 @entity1 (9.5%) (95% CI 5.3-14%) fulfilled the ACR criteria for the classification of FM. Of the @entity1 , 106 (56.1%) fulfilled criteria for @entity158 and had a number of tender points of 5.4 +/- 3.4, and the rest of the @entity1 (34.4%) had no tenderness at specific tender point sites. Age, body mass index, educational level and disease duration were comparable between the groups. FM and @entity158 groups had different patterns of symptoms prevalence, with @entity1834 being more distinctive for FM. Sleep disturbances were more severe in the FM than in the @entity158 group. Daytime complaints such as @entity308 were similar for @entity158 and FM groups, but @entity1 with FM reported more disability. @entity239 is not common in Mexican @entity1 with @entity1252 and has a different pattern of symptoms in @entity158 and NP @entity1 . These data add evidence that ethnicity can play an important role in FM manifestations.

title: Prevalence and factors associated with XXXX in Mexican @entity1 with @entity1252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['sleepiness, fatigue and depression', 'depression']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['Fibromyalgia', 'fibromyalgia']

entities_list: @entity1834 :: ('MESH:D004412', 'Disease') :: ['dysmenorrhea']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'RP', 'widespread pain', 'regional pain']

answer: @entity239 :: (MESH:D005356,Disease) :: ['fibromyalgia']


abstract: BACKGROUND: With concerns that blind registration in Ireland due to @entity6 is continuing to rise, a structured @entity989 screening service is in the process of being rolled out nationally. AIMS: To report on the validation process for creating a register of diabetics in the Mid-West of Ireland, and findings following @entity989 screening of a representative sample. METHODS: National primary care databases were employed in generating provisional lists of @entity6 @entity1 in the Health Service Executive (HSE) Mid-West area. Subsequent engagement with the corresponding general practices over a three year period between 2010 and 2013 facilitated the validation of these lists. A summary of the @entity989 screening outcomes of 1,434 @entity1 and pre-existing screening patterns is reported. RESULTS: The number of @entity1 on the Mid-West @entity6 register to date is 11,126. Of the 1,434 @entity1 screened, 288 (20.1  %) had background @entity989 , while 117 (8.2  %) had sight-threatening @entity989 . Seventeen (19.8  %) of the 86 @entity1 identified with @entity1020 required treatment with intravitreal injections. Of the 610 @entity1 questioned about previous screening events, 389 (63.8  %) said they had undergone an ocular examination within the previous 12  months. CONCLUSIONS: The HSE Mid-West has over 11,000 @entity1 on its database ready to be screened by the national programme, with the treatment of @entity1020 expected to have the largest impact on resources. Although the majority of @entity1 are already undergoing screening in the community in an ad hoc fashion, the rates of sight-threatening @entity989 encountered highlight the timeliness of the full implementation of the national programme.

title: Report on the creation of a @entity6 register and XXXX screening outcomes in the Mid-West of Ireland.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['maculopathy']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

answer: @entity989 :: (MESH:D012164,Disease) :: ['retinopathy']


abstract: BACKGROUND: This investigation assesses the efficacy of a voluntary nasogastric tube feeding protocol on the @entity1017 of @entity1 with @entity1278 , tube feeding's effect on recovery from the psychologic aspects of @entity448 , @entity1 satisfaction with treatment, and medical complications. METHODS: The study included a nonrandomized retrospective review of 381 female inpatients with a Diagnostic and Statistical Manual of @entity146 , Fourth Edition diagnosis of @entity1278 , both subtypes. A total of 155 @entity1 received tube feeding and oral refeeding; 226 received oral refeeding alone. Recovery from the psychologic aspects of @entity448 was measured by the change in Eating Disorder Inventory-2 scores between admission and discharge. @entity1 satisfaction with treatment was measured with a @entity1 satisfaction questionnaire completed at discharge. Repeated measures and multivariate analyses were performed. RESULTS: When severity-of-illness and caloric intake differences between @entity1 with and without tube feeding were controlled, @entity1 who received tube feeding gained significantly more weight per treatment week than those who received oral kilocalories alone. @entity1 who received tube feeding for at least one-half their length of stay gained 1 kg/week versus 0.77 kg/week for @entity1 receiving oral refeeding alone. Tube-fed @entity1 evidenced no differences in recovery from @entity448 's psychologic aspects, satisfaction with treatment, or medical complication frequency. CONCLUSIONS: In residential psychiatric treatment settings in which intensive therapeutic interventions and appropriate medical monitoring can manage potential psychologic and medical risks, tube feeding's @entity1017 may be a viable and safe option in treating @entity448 .

title: Efficacy of voluntary nasogastric tube feeding in female inpatients with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain benefits', 'weight gain']

answer: @entity1278 :: (MESH:D000856,Disease) :: ['anorexia nervosa']


abstract: OBJECTIVE: Carotid stenosis is associated with @entity2806 . Diffusion-weighted MR imaging allows for the assessment of changes related to alterations in tissue integrity. The aim of this study was to investigate (a) whether @entity62 ( @entity62 ) and apparent diffusion coefficient (ADC) values differ between ipsilateral and contralateral hemispheres, (b) whether ADC values are related to WMLs and common vascular risk factors, and (c) whether ADC values differ after carotid endarterectomy (CEA) without a shunt in @entity1 with @entity543 ( @entity543 ). METHODS: Twenty-five @entity1 (16 @entity1 , 9 @entity1 ; mean age of 68 years) with unilateral @entity543 (>= 70% @entity543 ) were assessed with brain MRI before and after CEA, prospectively. Two experienced radiologists scored the WMLs. Bilateral ADC values in anterior and posterior periventricular WM, occipital WM, and thalamus were evaluated on preoperative and postoperative MRI. Differences in ADC values and @entity62 scores between the two hemispheres were assessed and associations between ADC values, @entity62 scores, and explanatory variables (e.g., age, sex, vascular risk factors) were analyzed. RESULTS: WMLs were significantly greater and ADC values were elevated in the ipsilateral cerebral WM. After CEA, ADC values rapidly decreased but remained higher than within the contralateral hemisphere. Ipsilateral hemispheric ADC values were associated with basal ganglia WMLs. No association between ADC values and vascular risk factors was found. CONCLUSION: @entity543 is associated with increased diffusion in normal-appearing WM in comparison to more prominent chronic @entity2806 . CEA has a partial effect on diffusion. These cerebral changes may be related to chronic low-grade ischemic damage that is induced by @entity543 .

title: Brain diffusion changes in unilateral carotid artery stenosis with non-shunt endarterectomy: Correlation with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'WML']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'unilateral internal carotid artery stenosis', 'ICAS']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions', 'hemodynamic cerebral ischemia']

answer: @entity62 :: (MESH:D056784,Disease) :: ['white matter lesions']


abstract: Recently, a surgically resected case of @entity5 ( @entity5 ) with stromal osseous and @entity4648 was encountered. A CT scan showed calcification at the tail of the pancreas two years before the operation. In the resected specimen, macroscopically, the main pancreatic duct was dilated and filled with a whitish solid mass without mucinous material. The @entity5 showed mainly a solid and papillary growth pattern. The @entity5 cells had no evidence of acinar differentiation. The @entity5 cells, at the tail of the pancreas, invaded focally to surrounding pancreatic parenchyma with stromal desmoplastic and fibrosclerotic reaction and also formed nodular stromal osseous and @entity4648 . The @entity5 did not invade extrapancreatic tissue and showed no lymph node @entity3 . As there were no signs of chronic calcifying @entity788 , it is hypothesized that the metaplastic stroma was formed by a stromal reaction due to the @entity5 growth. It is thought, therefore, that the intraducal component of the @entity5 had existed at least for two years. This case suggests that @entity5 is a relatively indolent @entity5 with a better prognosis than that of other types of @entity1124 .

title: Intraductal XXXX ; a case report.

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['invasive ductal adenocarcinoma of the pancreas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['intraductal tubulopapillary neoplasm', 'tumor', 'ITPN']

entities_list: @entity4648 :: ('MESH:D008679', 'Disease') :: ['cartilaginous metaplasia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity788 :: (MESH:D010190,Disease) :: ['tubulopapillary neoplasm of pancreas with stromal osseous and cartilaginous metaplasia']


abstract: The inflammatory response of @entity295 results in @entity881 , including @entity296 . @entity296 is particularly important in @entity1 with severe @entity326 who progress to a hypodynamic pre-terminal phase. Multiple aspects of this septic inflammatory response contribute to the pathogenesis of decreased ventricular contractility. Inflammatory cytokines released by inflammatory cells contribute as does @entity842 released by vascular endothelium and by cardiomyocytes. Endotoxins and other pathogen molecules induce an intramyocardial inflammatory response by binding Toll-like receptors on cardiomyocytes that then signal via NF-kB. These processes alter cardiomyocyte depolarization and, therefore, contractility. The particular role of the cardiomyocyte @entity1372 current has not been characterized. Now new information suggests that the septic inflammatory response impairs normal depolarization by altering the cardiomyocyte @entity1372 current. This results in decreased ventricular contractility. This is important because new targets for therapeutic intervention can be considered and new approaches to evaluation of this problem can be contemplated.

title: Deeper understanding of mechanisms contributing to @entity295 -induced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial dysfunction', 'myocardial dysfunction']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['organ dysfunction']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial dysfunction']


abstract: INTRODUCTION: regular exercise has been recommended as an important behavior in controlling blood pressure. In recent years it has been demonstrated that a single session of exercise can lower blood pressure levels compared to pre-exercise period, becoming an effective non-pharmacological therapy for the treatment of @entity101 . OBJECTIVE: the purpose of this study was to analyze the levels of blood pressure in post-exercise period of controlled @entity101 @entity1 after an aerobics session and a hydrogymnastics session. METHODS: twelve elderly (65    3.6 years) who practice regular physical activity for at least two months had their levels of blood pressure measured during 60 minutes after the end of each session. Blood pressure was measured every five minutes after the end of each session until the twentieth minute of recovery. Following, blood pressure was measured every ten minutes. T-student test was used to compare mean and the level of significance adopted was 5%. RESULTS: the mean values of @entity551 found during the recovery period after the hydrogymnastics session were not significantly different when compared to blood pressure levels of the pre-exercise period (p = 0.260). However, the result of the same comparison for the aerobics session was statistically significant (p < 0.001). The lowest values of systolic blood pressure reached in the recovery period for hydrogymnastics (120 mmHg) and aerobics (106 mmHg) were significantly different (p < 0.001). CONCLUSIONS: the aerobics session showed to be more effective in reducing post-exercise blood pressure compared to the hydrogymnastics. After practice aerobics, the @entity1 presented lower blood pressure levels and longer duration of the @entity551 effect.

title: BLOOD PRESSURE IN HYPERTENSIVE XXXX AFTER AEROBICS AND HYDROGYMNASTICS SESSIONS.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive', 'hypotension']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

answer: @entity1 :: (9606,Species) :: ['WOMEN']


abstract: OBJECTIVE: To find previously unknown properties of @entity47179 , a competitive inhibitor of the cyclooxygenase and the lipoxygenase (LO) pathway. METHODS: Gene expression of @entity47179 treated and untreated @entity309 synovial fibroblasts were measured with Affymetrix gene arrays. Downregulation of chemokine (C-X-C motif) ligands @entity373 , @entity371 and @entity372 was verified with Real-time polymerase chain reaction, @entity371 protein levels were determined with ELISA. @entity309 synovial fibroblasts were treated with the cyclooxygenase inhibitor naproxen, the 5-LO inhibitor @entity64338 and the 5-lipoxygenase-activating protein (FLAP) inhibitor @entity20463 , and consecutive changes in @entity371 protein levels measured. 5-LO expression was determined by polymerase chain reaction and Western blot. RESULTS: In synovial fibroblasts and monocyte-derived macrophages @entity47179 inhibited the @entity5 @entity39 factor induced expression of @entity373 , @entity371 and @entity372 , which are all ligands of the chemokine receptor @entity366 . No effect was observed in monocytes. Whereas inhibition of the cyclooxygenase pathway or the FLAP protein showed no effect, blockade of 5-LO significantly downregulated @entity371 protein levels. 5-LO mRNA was detected in monocytes and in monocyte-derived macrophages. All tested cell types expressed 5-LO protein. CONCLUSIONS: @entity47179 effectively downregulates @entity366 ligands. This study confirms that a thorough analysis of the impact of a drug on its target cells cannot only reveal unexpected properties of a substance, but also helps to understand the underlying molecular mechanisms. Accordingly, our data provide the basis for further clinical studies testing the application of @entity47179 in diseases such as @entity309 or @entity15 .

title: The dual inhibitor of lipoxygenase and cyclooxygenase @entity47179 decreases the expression of XXXX ligands.

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'Rheumatoid arthritis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

answer: @entity366 :: (2833,Gene) :: ['CXCR3']


abstract: INTRODUCTION: Gender-affirming surgery is common for the treatment of @entity18268 , but its effect on genital sensitivity is not well known. AIMS: To investigate genital sensory detection thresholds in male-to-female transgender @entity1 postoperatively and their relation to psychological well-being and variables of satisfaction. METHODS: Prospective study on 28 transgender @entity1 at least 18 years old operated on at least 3 months before the study by a single surgeon (N.M.J.). MAIN OUTCOME MEASURES: Medical complications; sensory detection thresholds for light touch, pressure, and vibration; and questionnaires on general and sexual satisfaction, sexual function, @entity308 , and psychological well-being. RESULTS: Sensory detection thresholds ranged from 0.07 to 2.82 g for light touch, with the neck being most sensitive; from 20.23 to 34.64 g for pressure, with similar results for the neck and clitoris; and from 0.0052 to 0.0111 V for vibration, with similar findings for all stimulation points. Satisfaction with the appearance of the labia, vulva, clitoris, and sexual function was good to very good. Frequency of sexual activities increased significantly postoperatively for orogenital stimulation and decreased significantly for frequency of fantasies (t  =  -4.81; P < .0001). Orgasmic function was reported by 80% of @entity1 . Psychological adjustment was good to very good, with low @entity308 scores. Sexual satisfaction was statistically and positively correlated with vaginal function and depth, clitoral sensation, appearance of the @entity31756 , and natural lubrication and negatively correlated with @entity308 scores. CONCLUSION: Gender-affirming surgery yields good results for satisfaction with appearance and function. Genital sensitivity showed the best results with pressure and vibration.

title: Genital Sensory Detection Thresholds and XXXX Satisfaction With Vaginoplasty in Male-to-Female Transgender @entity1 .

entities_list: @entity31756 :: ('MESH:D014846', 'Disease') :: ['vulva and labia minora']

entities_list: @entity18268 :: ('MESH:D019968', 'Disease') :: ['gender dysphoria']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: Access to @entity146 treatment by @entity1 with @entity6004 in the general population is likely to be affected both by the severity of @entity74 and by sociodemographic differences. In the household component of the National Surveys of Psychiatric Morbidity >10,000 subjects in Great Britain with @entity146 symptoms were interviewed using the CIS-R. They were also asked about difficulties experienced in performing seven types of everyday activity. All subjects classed as having an @entity1479 were questioned about their experience of treatment with antidepressants, hypnotics, and counselling or psychotherapy. Less than 14% of @entity1 with current @entity6004 were receiving treatment for them. Within the previous year, only a third had made contact with their primary care physician for their mental problem: of these <30% were receiving treatment. Overall, 9% of @entity1 with disorders were given medication and 8% counselling or psychotherapy. A diagnosis of @entity308 was that most associated with antidepressant medication. Treatment access was affected by employment status, marital status, and age, but the major determinant was symptom severity. Neither sex nor social class influenced which @entity1 received treatment. @entity1 with @entity146 seldom receive treatment, even when they have consulted their primary care physician about them. In many cases, this must represent unmet needs with a strong claim on health resources. There are also inequalities in the receipt of treatment, although the major influence is the severity of @entity74 .

title: @entity6004 and the receipt of XXXX treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['People', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive episode']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders']

entities_list: @entity6004 :: ('MESH:D009497', 'Disease') :: ['neurotic disorders']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['disorder']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: Experiment 1 in the present study investigated the time course and dose range of @entity2932 ( @entity2933 ) to reduce voluntary @entity1068 intake in selectively bred Sardinian @entity1068 -preferring (sP) @entity35 . @entity1068 (10%, v/v) and tap water were offered under the two-bottle free choice regimen with unlimited access. @entity2933 (200, 300, and 400 mg/kg, i.p.) was administered 15 20 min prior to the start of the dark phase of the light-dark cycle. @entity1068 and water intakes were recorded at different time intervals during the dark phase. @entity2933 significantly reduced @entity1068 intake at doses of 300 and 400 mg/kg; statistical significance occurred only at the 15-min and 30-min observation times. The @entity2933 dose of 300 mg/kg was devoid of any sedative effect, as demonstrated in Experiment 2 by the lack of any impairment of spontaneous locomotor activity. Finally, this dose of @entity2933 was also found to exert a robust anxiolytic effect in sP @entity35 tested on the elevated plus maze (Experiment 3). Collectively, the results of the present study demonstrate that a non-sedative and anxiolytic dose of @entity2933 effectively reduced voluntary @entity1068 intake in sP @entity35 . The rapid onset of the reducing effect of @entity2933 on @entity1068 intake, as well as its anxiolytic effect, are discussed in terms of adding further support to the hypothesis that @entity2933 may control @entity167 craving and consumption in @entity1 by substituting for @entity1068 's reinforcing effects.

title: @entity2932 reducing effect on XXXX intake: evidence in favour of a substitution mechanism.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity2932 :: ('MESH:C111420', 'Chemical') :: ['gamma-hydroxybutyric acid']

entities_list: @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']


abstract: PURPOSE The purpose of this study was to evaluate the diagnostic value of Tc-99m-labeled antigranulocyte antibody fragments in the diagnosis of @entity4034 . MATERIALS AND METHODS Thirty immunoscintigrams were evaluated retrospectively with 740 MBq (20 mCi) Tc-99m-labeled antigranulocyte antibodies. The final diagnoses were confirmed by histology, magnetic resonance imaging, computed tomography, and clinical follow-up. RESULTS In the retrospective analysis, 20 of 30 @entity1 (67%) demonstrated a true-positive result. Three of 30 @entity1 (10%) had a false-positive result. A false-negative result was found in a @entity6 @entity1 with a perforating @entity1411 . Six of 30 @entity1 had a true-negative result. A high sensitivity of 95%, a relatively high specificity of 67%, and a high diagnostic accuracy of 86% were present in this study. CONCLUSION Tc-99m labeled monoclonal antibody- @entity1334 ' fragments are suitable for the detection of @entity4034 . Its clinical application is simple. Its use guarantees a reliable and accurate diagnostic result just 1 to 2 hours after injection, making a late scan unnecessary. @entity570 or @entity4916 can lead to false-positive results. A perforating @entity1411 may result in a false-negative conclusion.

title: Imaging XXXX with Tc-99m-labeled antigranulocyte antibody @entity1334 ' fragments.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4916 :: ('MESH:D015576', 'Disease') :: ['hyperostosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity1411 :: ('MESH:D016523', 'Disease') :: ['ulcer of the foot']

entities_list: @entity570 :: ('MESH:D015207', 'Disease') :: ['Coxarthrosis']

answer: @entity4034 :: (MESH:D010019,Disease) :: ['osteomyelitis']


abstract: OBJECTIVE: Bedside @entity358 ( @entity358 ) is a noninvasive, readily available imaging modality that can complement clinical evaluation. The Bedside Lung Ultrasound in Emergency (BLUE) protocol has demonstrated a high diagnostic accuracy in @entity1 with @entity1576 ( @entity1576 ). Recently, bedside @entity358 has been added to the medical training program of our ICU. The aim of this study was to investigate the accuracy of @entity358 based on the BLUE protocol, when performed by physicians who are not ultrasound experts, to guide the diagnosis of @entity1576 . METHODS: Over a one-year period, all spontaneously @entity1353 adult @entity1 consecutively admitted to the ICU for @entity1576 were prospectively included. After training, 4 non-ultrasound experts performed @entity358 within 20 minutes of @entity1 admission. They were blinded to @entity1 medical history. @entity358 diagnosis was compared with the final clinical diagnosis made by the ICU team before @entity1 were discharged from the ICU (gold standard). RESULTS: Thirty-seven @entity1 were included in the analysis (mean age, 73.2    14.7 years; APACHE II, 19.2    7.3). @entity358 diagnosis had a good agreement with the final diagnosis in 84% of @entity1 (overall kappa, 0.81). The most common etiologies for @entity1576 were @entity55 (n = 17) and @entity4 (n = 15). The sensitivity and specificity of @entity358 as measured against the final diagnosis were, respectively, 88% and 90% for @entity55 and 86% and 87% for @entity4 . CONCLUSIONS: @entity358 based on the BLUE protocol was reproducible by physicians who are not ultrasound experts and accurate for the diagnosis of @entity55 and @entity4 .

title: Diagnostic accuracy of the Bedside Lung Ultrasound in Emergency protocol for the diagnosis of @entity1576 in spontaneously XXXX @entity1 .

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['hemodynamic lung edema']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['LUS', 'lung ultrasound']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['ARF', 'acute respiratory failure']

answer: @entity1353 :: (MESH:D004417,Disease) :: ['breathing']


abstract: BACKGROUND: @entity955 ( @entity955 ) is associated with @entity73 and may contribute to an increased risk of @entity303 . The goal of the present study was to investigate whether statin use prevented @entity1294 in subjects with @entity955 . METHODS: Data from the National Health Insurance Research Database of Taiwan were used in this study. The study group comprised 51,253 @entity955 subjects aged >= 60years who had received statin treatment. For each study @entity1 , four age- and sex-matched @entity955 subjects without statin exposure were selected as the control group (n=205,012). The risk of @entity1294 was compared between the statin and control groups. RESULTS: During the follow-up period, 17,201 @entity1 experienced @entity1294 . The annual incidence of @entity1294 was lower in the statin group than in the control group (1.89% vs. 2.20%; p<0.001). Statin use exhibited a protective effect on the occurrence of @entity1294 , with an adjusted hazard ratio (HR) of 0.832 (95% confidence interval=0.801-0.864). Among statin types, the use of @entity8671 was associated with the largest risk reduction (adjusted HR=0.661). Statin exposure duration was related inversely to the risk of @entity1294 . CONCLUSIONS: In this large-scale nationwide cohort study, @entity6817 use was associated with a lower risk of @entity1294 in @entity955 . Use of more potent statin and longer exposure time may be associated with greater benefits.

title: XXXX and the risk of @entity303 in @entity1 with @entity955 : A nationwide population-based cohort study.

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['non-vascular dementia']

entities_list: @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial fibrillation', 'AF']

answer: @entity6817 :: (D019821,Chemical) :: ['Statins']


abstract: BACKGROUND: @entity3932 ( @entity3932 ) is characterized by @entity3809 ( @entity3809 ) affecting the face, eyes, and central nervous system. Pulsed dye laser ( @entity10662 ) is the standard treatment for @entity3809 . Unfortunately, recurrence is frequent because of reformation and reperfusion of blood vessels. OBJECTIVE: We sought to assess the clinical efficacy of topical @entity3446 combined with @entity10662 in @entity3809 of @entity1 with @entity3932 . METHODS: We conducted a phase II, randomized, double-blind, intraindividual placebo-controlled, clinical trial. We recruited 23 @entity1 with @entity3932 and facial @entity3809 (12 @entity1 ; median age 33 years, age range 17-65 years) from the University Clinic of Navarra, Spain. Four interventions were evaluated: placebo, @entity10662 + placebo, @entity3446 , and @entity10662 + @entity3446 . Clinical and histologic responses were evaluated using a chromatographic computerized system, spectrometry, and histologic analyses at 6, 12, and 18 weeks after the intervention. RESULTS: @entity10662 + @entity3446 yielded the lowest digital photographic image score and the lowest percentage of vessels in histologic analysis, and showed a statistically significant improvement compared with the other interventions. The treatment was generally well tolerated. LIMITATIONS: @entity10662 was only applied to the lateral parts of the @entity3809 area. CONCLUSION: Topical @entity3446 associated with @entity10662 seems to be an effective treatment for @entity3809 in @entity1 with @entity3932 .

title: Topical @entity3446 combined with pulsed dye laser in the treatment of capillary vascular malformations in XXXX : Phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity3932 :: ('MESH:D013341', 'Disease') :: ['Sturge-Weber syndrome', 'SWS']

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin']

entities_list: @entity3809 :: ('MESH:D019339', 'Disease') :: ['PWS', 'port-wine stains']

answer: @entity3932 :: (MESH:D013341,Disease) :: ['Sturge-Weber syndrome']


abstract: PURPOSE: To compare @entity551 effect of latanoprost versus @entity6839 - @entity15438 association on @entity1 with @entity726 . MATERIAL AND METHOD: We studied 102 eyes in 52 @entity1 with intraocular pressure (IOP) higher than 21 mmHg, previously treated with a betablocker. @entity1 were divided in two groups. Treatment was changed on group 1 (51 eyes in 27 @entity1 ) to a @entity6839 - @entity15438 association. Group 2 (51 eyes in 27 @entity1 ) changed treatment to latanoprost. After determination of previous IOP, readings were taken at 1, 3 and 8 months later. RESULTS: Both groups showed a decrease in IOP levels: Group 1, 5.6 mmHg and Group 2, 8.5 mmHg. Association between @entity6839 and @entity15438 reached the highest @entity551 effect after the first month of treatment and remained constant during the rest of the study period. Latanoprost showed a maximal effect after the third month of treatment and maintained its effect all through the study as well. Latanoprost behaved similar to associated @entity6839 - @entity15438 not showing significant differences during the first month of treatment. Significant differences appeared at third and eighth month favoring latanoprost (p<0.005 and p<0.001 respectively). CONCLUSION: There was a similarity in efficacy of both treatments. However, after the third month latanoprost became more effective than the @entity6839 - @entity15438 association.

title: [Study on @entity551 effect of latanoprost vs @entity6839 - XXXX association].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity15438 :: ('MESH:C062765', 'Chemical') :: ['dorzolamide']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

answer: @entity15438 :: (MESH:C062765,Chemical) :: ['dorzolamide']


abstract: OBJECTIVES: We evaluated the results of short-segment posterior instrumentation of thoracolumbar burst @entity174 and investigated correlations between radiographic and functional results as well as factors that affected correction losses. METHODS: We reviewed 48 @entity1 (30 males, 18 females; mean age 40+/-14 years; range 18 to 67 years) who underwent short-segment posterior instrumentation with pedicle screws and fusion. The most common involvement was at L1 in 18 @entity1 (37.5%), followed by T12 in 11 @entity1 (22.9%). According to the Frankel grading system, six @entity1 had complete, 14 @entity1 had @entity51 . The Cobb angles were measured, and canal remodeling was assessed by computed tomography. Modified functional results were derived using the @entity158 and work scales. The mean follow-up was 21.7+/-9.1 months (range 12 to 48 months). RESULTS: The mean correction in the Cobb angle was 18.2+/-8.6 degrees (p<0.01), the mean correction loss was 7.4+/-5.7 degrees (p<0.01), and the mean canal remodeling was 51.3+/-9.3% (p<0.001). There was a significant correlation between Cobb angle correction and correction loss (r=0.38, p<0.01). An intraoperative correction of greater than 15 degrees was significantly associated with a greater correction loss (p<0.05). @entity1 with a correction loss of more than 10 degrees had a significantly poorer @entity158 score and modified functional result (p<0.05). Modified functional results were excellent in 16 @entity1 (33.3%), good in 23 @entity1 (47.9%), fair in seven @entity1 (14.6%), and poor in two @entity1 (4.2%). At final follow-ups, the Cobb angle was not correlated with functional results (p>0.05). All the @entity1 having @entity51 improved by at least 1 Frankel grade. CONCLUSION: An intraoperative correction exceeding 15 degrees is significantly associated with a greater correction loss, which in turn has a significantly adverse effect on functional results.

title: [The effectiveness of short-segment posterior instrumentation of thoracolumbar burst XXXX ].

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['incomplete neurologic deficits']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Denis pain']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: OBJECTIVE: To determine the impact on progression-free survival (PFS) and @entity1349 ( @entity1349 ) of a programmatic change in surgical approach to @entity43 . METHODS: Two groups of @entity1 with stage IIIC and @entity43 were compared. Group 1, the control group, consisted of all 168 @entity1 who underwent primary cytoreduction from 1/96 to 12/99. Group 2, the study group, consisted of all 210 @entity1 who underwent primary surgery from 1/01 to 12/04, during which time a more comprehensive debulking of @entity1625 was utilized. RESULTS: There were no differences between the groups in age, primary site of disease, surgical stage, @entity5 grade, American Society of Anesthesiologists class, preoperative serum @entity10224 and platelet levels, percentage with or amount of @entity843 , size or location of @entity5 mass, or type of postoperative chemotherapy. @entity1 in Group 2 vs Group 1 more frequently had extensive upper abdominal procedure(s) (38% vs 0%, respectively; P<0.001) and cytoreduction to residual disease <1 cm (80% vs 46%, respectively; P<0.01). Five-year PFS and @entity1349 rates were significantly improved in Group 2. For Group 2 vs Group 1 @entity1 , 5-year PFS rates were 31% vs 14%, respectively (hazard ratio, 0.757; 95% CI, 0.601-0.953; P=0.01]; and 5-year @entity1349 rates were 47% vs 35%, respectively (HR, 0.764; 95% CI, 0.592-0.987; P=0.03]. CONCLUSION: The incorporation of extensive upper abdominal procedures resulted in increased optimal cytoreduction rates and significantly improved PFS and @entity1349 . A paradigm shift toward more complete primary cytoreduction can improve survival for @entity1 with advanced @entity43 .

title: Improved progression-free and XXXX in advanced @entity43 as a result of a change in surgical paradigm.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['IV ovarian, tubal, and peritoneal carcinoma', 'advanced epithelial ovarian cancer', 'ovarian, tubal, and peritoneal carcinomas']

entities_list: @entity1625 :: ('MESH:D004828', 'Disease') :: ['upper abdominal disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'largest tumor']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1349 :: (MESH:D011475,Disease) :: ['overall survival']


abstract: OBJECTIVES: To identify risk factors for a massive amount of @entity843 after liver resection to treat @entity157 and to evaluate our postoperative management strategy. DESIGN: Case-control study. SETTING: University hospital. @entity1 : Two hundred three @entity1 who underwent liver resection to treat @entity157 between January 1, 2003, and December 31, 2004. MAIN OUTCOME MEASURES: Presence or absence of a large number of @entity843 (LA), defined as postoperative daily ascitic fluid drainage exceeding 10 mL per kilogram of body weight, and operative morbidity, mortality, and treatment costs. RESULTS: A large number of @entity843 developed in 31 @entity1 (15%). Multivariate analysis revealed that @entity190 greater than 1000 mL (relative risk, 6.38; 95% confidence interval, 2.19-20.7; P = .001) and preoperative platelet count less than 100 x 10(3)/microL (4.75; 1.75-13.1; P = .002) independently increased the risk of LA. In @entity1 with LA, urinary output on postoperative days 1 to 3 was significantly lower than in @entity1 without LA, and daily ascitic fluid volume tended to peak on postoperative day 7. No operative mortality was related to @entity1578 ; however, @entity1 with LA required a larger volume of fresh frozen plasma than those without LA (median [range], 1600 [0-16 800] mL vs 480 [0-5760] mL; P < .001), resulting in higher hospital costs. CONCLUSIONS: Large @entity190 and low platelet count were independent risk factors for LA. Although it was possible to safely manage postoperative @entity843 using routine administration of diuretic agents and fresh frozen plasma, step-by-step trials are required to reduce the need for transfusion of fresh frozen plasma.

title: Risk factors and management of XXXX after liver resection to treat @entity157 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

answer: @entity843 :: (MESH:D001201,Disease) :: ['ascites']


abstract: BACKGROUND: The aetiology of @entity0 remains elusive. A viral aetiology has been proposed, but to date no virus has been conclusively demonstrated to be involved. Recently, two new viruses, namely @entity6059 (MCV) and xenotropic @entity19 @entity1778 virus-related virus (XMRV) have been identified and implicated in the pathogenesis of @entity3852 ( @entity3852 ) and @entity263 , respectively. METHODS: We examined 204 samples from 58 different cases of @entity0 for presence of MCV or XMRV by PCR. Samples consisted of both malignant and non-malignant tissues. Additionally, we included 6 cases of @entity3852 and 12 cases of @entity263 as potential controls for MCV and XMRV, respectively. RESULTS: All of the @entity0 samples examined were negative for both MCV and XMRV. However, 4/6 @entity3852 and 2/12 @entity263 samples were found to be positive for MCV and XMRV, respectively. Sequence analysis of the amplified products confirmed that these sequences belonged to MCV and XMRV. CONCLUSION: We conclude that there is no evidence for the involvement of MCV or XMRV in the pathogenesis of @entity0 . What role these viruses have in the pathogenesis of @entity263 remains to be demonstrated.

title: No evidence for the involvement of XMRV or MCV in the pathogenesis of XXXX .

entities_list: @entity3852 :: ('MESH:D015266', 'Disease') :: ['Merkel cell carcinoma', 'MCC']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['familial form of prostate cancer', 'prostate cancer', 'MCC and prostate carcinomas']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia']

entities_list: @entity6059 :: ('493803', 'Species') :: ['Merkel cell polyomavirus']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Purpose Since 2000, many new treatment options have become available for relapsed and/or refractory multiple @entity1582 (R/R MM) after a long period in which @entity619 and @entity3601 had been the standard treatment. Direct comparisons of these novel treatments, however, are lacking. This makes it extremely difficult to evaluate the relative added value of each new treatment. Our aim was to synthesize all efficacy evidence, enabling a comparison of all current treatments for R/R MM. Methods We performed a systematic literature review to identify all publicly available phase III randomized controlled trial evidence. We searched Embase, MEDLINE, MEDLINE In-Process, Cochrane Central Register of Controlled Clinical Trials, and the Web site www.ClinicalTrials.gov . In addition, two trials presented at two international hematology congresses (ie, ASCO 2016 and European Hematology Association 2016) were added to include the most recent evidence. In total, 17 randomized controlled trials were identified, including 18 treatment options. The evidence was synthesized using a conventional network meta-analysis. To include all treatments within one network, two treatment options were combined: (1) @entity1749 monotherapy and @entity1749 plus @entity619 , and (2) @entity2816 monotherapy and @entity2816 plus @entity619 . Results The combination of daratumumab, @entity6985 , and @entity619 was identified as the best treatment. It was most favorable in terms of (1) hazard ratio for progression-free survival (0.13; 95% credible interval, 0.09 to 0.19), and (2) probability of being best (99% of the simulations). This treatment combination reduced the risk of progression or @entity204 by 87% versus @entity619 , 81% versus @entity1749 plus @entity619 , and 63% versus @entity6985 plus @entity619 . Conclusion Our network meta-analysis provides a complete overview of the relative efficacy of all available treatments for R/R MM. Until additional data from randomized studies are available, on the basis of this analysis, the combination of daratumumab, @entity6985 , and @entity619 seems to be the best treatment option.

title: Systematic Literature Review and Network Meta-Analysis of Treatment Outcomes in Relapsed and/or Refractory XXXX .

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide']

entities_list: @entity3601 :: ('MESH:D008558', 'Chemical') :: ['melphalan']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity6985 :: ('MESH:C467567', 'Chemical') :: ['lenalidomide']

entities_list: @entity1749 :: ('MESH:C400082', 'Chemical') :: ['bortezomib']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['Multiple Myeloma']


abstract: In this study, we investigated the role of the peripheral @entity15486 ( @entity15486 ) concentration in a @entity5 model. To test the hypothesis that the concentration of @entity15486 in the @entity5 microenvironment is important in determining the level of @entity5 we used two @entity5 @entity19 models that differed significantly in production of @entity15486 . The two @entity19 @entity5 models were produced by injection of cells derived from a @entity1 @entity957 (SCC) and @entity320 into the hind paw of female @entity19 . @entity158 , as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, was significantly greater in the SCC group than the @entity320 group. The peripheral concentration of @entity15486 within the @entity5 microenvironment was significantly greater in the SCC group. Intra- @entity5 expression of both @entity15486 mRNA and @entity15486 protein were significantly higher in the SCC model compared to the @entity320 model. ET receptor antagonism was effective as an analgesic for @entity5 in the SCC model only. To address the potential confounding factor of @entity5 volume we evaluated the contribution of @entity5 volume to @entity5 in the two models. The mean volumes of the @entity5 in the @entity320 group were significantly greater than the @entity5 in the SCC group. In both groups, the @entity158 level correlated with @entity5 volume, but the correlation was stronger in the @entity320 group. We conclude that @entity15486 concentration is a determinant of the level of @entity158 in a @entity5 @entity19 model and it is a more important factor than @entity5 volume in producing @entity5 . These results suggest that future treatment regimens for @entity5 directed at @entity15486 receptor antagonism show promise and may be @entity5 type specific.

title: Effect of peripheral XXXX concentration on carcinoma-induced @entity158 in @entity19 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'cancer pain', 'tumors']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['oral squamous cell carcinoma']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity15486 :: (13614(Tax:10090),Gene) :: ['endothelin-1']


abstract: Manual therapy, exercise and education target distinct aspects of @entity1643 and probably have distinct effects. This study aimed to determine the efficacy of a combined physiotherapy treatment that comprised all of these strategies. By concealed randomisation, 57 @entity1643 @entity1 were allocated to either the four-week physiotherapy program or management as directed by their general practitioners. The dependent variables of interest were @entity158 and disability. Assessors were blind to treatment group. Outcome data from 49 subjects (86%) showed a significant treatment effect. The physiotherapy program reduced @entity158 and disability by a mean of 1.5/10 points on a numerical rating scale (95% CI 0.7 to 2.3) and 3.9 points on the 18-point Roland Morris Disability Questionnaire (95% CI 2 to 5.8), respectively. The number needed to treat in order to gain a clinically meaningful change was 3 (95% CI 3 to 8) for @entity158 , and 2 (95% CI 2 to 5) for disability. A treatment effect was maintained at one-year follow-up. The findings support the efficacy of combined physiotherapy treatment in producing symptomatic and functional change in moderately disabled @entity1643 @entity1 .

title: Combined physiotherapy and education is efficacious for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['chronic low back pain']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['chronic low back pain']


abstract: UNASSIGNED: Variability in @entity2067 antagonist (VKA) dosing is partially explained by genetic polymorphisms. We performed a meta-analysis to determine whether genotype-guided VKA dosing algorithms decrease a composite of @entity204 , @entity1031 events and @entity548 (primary outcome) and improve time in therapeutic range (TTR). We searched MEDLINE, EMBASE, CENTRAL, trial registries and conference proceedings for randomised trials comparing genotype-guided and standard (non genotype-guided) VKA dosing algorithms in adults initiating anticoagulation. Data were pooled using a random effects model. Of the 12 included studies (3,217 @entity1 ), six reported all components of the primary outcome of mortality, @entity1031 events and @entity548 (2,223 @entity1 , 87 events). Our meta-analysis found no significant difference between groups for the primary outcome (relative risk 0.85, 95   % confidence interval [CI] 0.54-1.34; heterogeneity     =4.46, p=0.35, I  =10   %). Based on 10 studies (2,767 @entity1 ), TTR was significantly higher in the genotype-guided group (mean difference (MD) 4.31   %; 95   % CI 0.35, 8.26; heterogeneity     =43.31, p<   0.001, I  =79   %). Pre-specified exploratory analyses demonstrated that TTR was significantly higher when genotype-guided dosing was compared with fixed VKA dosing (6 trials, 997 @entity1 : MD 8.41   %; 95   % CI 3.50,13.31; heterogeneity     =15.18, p=0.01, I  =67   %) but not when compared with clinical algorithm-guided dosing (4 trials, 1,770 @entity1 : MD -0.29   %; 95   % CI -2.48,1.90; heterogeneity     =1.53, p=0.68, I  =0   %; p for interaction=0.002). In conclusion, genotype-guided compared with standard VKA dosing algorithms were not found to decrease a composite of @entity204 , @entity1031 and @entity548 , but did result in improved TTR. An improvement in TTR was observed in comparison with fixed VKA dosing algorithms, but not with clinical algorithms.

title: Genotype-guided versus standard XXXX antagonist dosing algorithms in patients initiating anticoagulation. A systematic review and meta-analysis.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['major bleeding']

entities_list: @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism', 'thromboembolic']

answer: @entity2067 :: (MESH:D014812,Chemical) :: ['vitamin K']


abstract: AIMS: To identify and characterize bacteriocion-producing @entity880 bacteria (LAB) in sourdoughs and to compare in vitro and in situ @entity5618 activity of sourdough- and nonsourdough LAB. METHODS AND RESULTS: Production of antimicrobial compounds by 437 @entity4414 strains isolated from 70 sourdoughs was investigated. Five strains ( @entity4414 2MF8 and 8CF, Lb. plantarum 4DE and 3DM and @entity4414 spp. CS1) were found to produce distinct @entity5618 -like inhibitory substances (BLIS). BLIS-producing @entity7878 isolated from raw @entity2247 showed a wider inhibitory spectrum than sourdough LAB, but they did not inhibit all strains of the key sourdough bacterium Lb. sanfranciscensis. Antimicrobial production by Lb. pentosus 2MF8 and Lc. lactis M30 was also demonstrated in situ. CONCLUSIONS: BLIS production by sourdough LAB appears to occur at a low frequency, showing limited inhibitory spectrum when compared with BLIS-producing Lc. lactis. Nevertheless, they are active BLIS producers under sourdough and bread-making conditions. SIGNIFICANCE AND IMPACT OF THE STUDY: The activity of BLIS has been demonstrated in situ. It may influence the complex sourdough microflora and support the implantation and stability of selected insensitive bacteria, such as Lb. sanfranciscensis, useful to confer good characteristics to the dough.

title: Characterization of @entity5618 -like inhibitory substances (BLIS) from sourdough XXXX bacteria and evaluation of their in vitro and in situ activity.

entities_list: @entity5618 :: ('CHEBI:48081', 'Chemical') :: ['bacteriocin']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

entities_list: @entity7878 :: ('1358', 'Species') :: ['Lactococcus lactis']

entities_list: @entity4414 :: ('1589', 'Species') :: ['Lactobacillus pentosus', 'Lactobacillus']

answer: @entity880 :: (MESH:D019344,Chemical) :: ['lactic acid']


abstract: It is unknown whether leaving the skin wound open to heal by secondary intention is associated with a lower rate of wound @entity281 compared with primary @entity272 after operations for @entity1049 . From June 1998 to December 2000 at our Level I academic @entity130 center 48 @entity1 entered into a randomized controlled trial (RCT) and were randomized to have their skin wound primarily closed (CLOSED-RCT) or left open (OPEN-RCT). At the same time @entity1 not included in the RCT were followed prospectively. At the discretion of the surgeon their skin wounds were managed by primary closure (CLOSED-nonRCT) or were left open (OPEN-nonRCT). Univariate and multivariate analysis was done to identify independent risk factors of @entity2737 , wound @entity6783 , and @entity39 soft tissue @entity281 . @entity2737 developed in 65 per cent of CLOSED-RCT and 36 per cent of OPEN-RCT @entity1 (P = 0.04) and wound @entity6783 in 31 per cent and 14 per cent respectively (P = 0.18). No remarkable differences were noted in any other variable including length of hospital stay. @entity2737 developed in 29 per cent of CLOSED-nonRCT and 15 per cent of OPEN-nonRCT @entity1 (P = 0.46). There were three independent risk factors of @entity2737 : primary wound closure [odds ratio (OR) = 5.5, 95% confidence interval (CI) = 1.8-19.4], colectomy (OR = 3.4, 95% CI = 1.2-10.4), and @entity1320 (OR = 5.3, 95% CI = 1.3-24.2). There were two independent risk factors for wound @entity6783 and/or @entity39 soft tissue @entity281 : @entity2737 (OR = 20.9, 95% CI = 4.9-152.3) and @entity1320 (OR = 19.3, 95% CI = 4.0-146.9). Primary closure of the wound almost doubles the rate of @entity2737 compared with leaving the wound open in operations for @entity1049 . Primary wound closure is a risk factor for @entity2737 and @entity2737 is a risk factor for wound @entity6783 or @entity39 soft tissue @entity281 . Because of the complexity of evaluating the real clinical significance of superficial @entity2737 larger studies on @entity130 @entity1 are required.

title: Wound management after XXXX : open or closed? A prospective randomized trial.

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotizing']

entities_list: @entity1049 :: ('MESH:D003108', 'Disease') :: ['colon injuries']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infection', 'wound infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity6783 :: ('MESH:D013529', 'Disease') :: ['dehiscence']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin-wound closure']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal infection', 'intraabdominal infection']

answer: @entity1049 :: (MESH:D003108,Disease) :: ['colon injury']


abstract: @entity1893 are @entity1071 that originate from B or T-lymphocytes and rarely from NK cells. They represent an extremely heterogeneous group of diseases regarding histologic subtypes, clinical presentations, immunophenotypic profiles, cytogenetic and molecular features and suitable mode of treatment. A clinical indicator of prognosis, the International Prognostic Index, takes into account factors that are mostly linked to @entity1 characteristics (age, performance status) and to disease extension and growth (disease stage, s. @entity880 dehydrogenase level and extent of extranodal involvement). However, it is clear that differences in clinical features and in treatment responses are a result of the marked genetic, immunophenotypic and molecular heterogeneity that underlie @entity146 and @entity5 progresssion. We applied IPI (based on pretreatment clinical characteristics) in our group of 136 @entity1 that identified a subgroup of clinical features that remained independently significant in multivariate analyses. In our results IPI turned out to be of prognostic significance for response rate and survival percentages. Based on their number of "poor risk" factors, @entity1 were placed into four IPI risk groups: low (one or no risk factors), low-intermediate (two risk factors), intermediate-high (three risk factors), and high (four or five risk factors) with five years survival rates of 88%; 82%; 18% and 0% respectively. However, one limitation of this prediction strategy is that IPI does not encompass molecular @entity5 cells, which may play a critical role in determining profoundly different clinical outcomes in @entity1 within the same group as defined by IPI. The aim of this study was to assess the clinical significance and potential prognostic value of the expression of the new immunologic prognostic markers including nuclear proliferating antigen, suppressor and oncogenic proteins, HLA-DR surface antigens, @entity5 infiltrating T-lymphocytes, lymphocyte homing receptor and angiogenic molecules. Immunohistochemistry was used to examine paraffin-embedded @entity5 tissues for determining the expression of immunologic prognostic markers. Survival analysis showed that serum-high @entity880 dehydrogenase level, poor performance status (ECOG 3, 4 and 5), high proliferative activity defined as nuclear Ki67 expression greater than 60% of malignant cells and high @entity5 invasive potential defined by discontinued or loss of Collagen IV were found as strong predictors of poor survival among these @entity1 . These four prognostic parameters determined the New-PI with three risk groups: good (0-1 risk factors), intermediate (2 risk factors) and poor (3 and more risk factors), with predicted five-years survival rates of 88%, 64% and 0%. The New-PI more accurately predicts the outcome than the standard IPI (p < 0,001 vs. p < 0.0001). Based on a single institution series of 136 @entity1 the IPI has proved to be a useful prognostic tool for @entity1893 @entity1 . Addition of new cellular markers into the standard IPI significantly improves risk stratification in @entity1893 .

title: XXXX : immunologic prognostic studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1071 :: ('MESH:D008232', 'Disease') :: ['malignant lymphoproliferative disorders']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['disease aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['abnormalities of tumour', 'tumour']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', "Non-Hodgkin's lymphomas"]

answer: @entity1893 :: (MESH:D008228,Disease) :: ['Non-Hodgkin's lymphomas']


abstract: The diagnosis and treatment of @entity2169 could be rendered optimal by employing tympanometry (measurement of the pressure in the middle ear) which is already known from specialist practice. This was investigated by means of a controlled investigation with cooperation between general practice, otologists and the health services in the County of Vejle. Following randomizing among 20 general practitioners, ten were trained in tympanometry (the test group) while ten did not change their principles for diagnosis and treatment (control group). The criteria for inclusion in the investigation were the findings of indications for otoscopy in @entity1 under the age of 16 years. During a period of 12 months, parallel registrations of the data were made in the two groups and 3,166 @entity1 with an average age of 3.4 years were included. The clinical course showed statistically significant differences (p less than 0.05) between the groups as regards diagnosis and treatment: @entity697 was found in 8.4% in the control group and 2.6% in the test group. @entity2171 (glue ear) was found in 14.2% in the control group and in 25% in the test group. Correspondingly, @entity114 was prescribed for 7.6% in the control group and 4.1% in the test group. The otologists performed tubulation of the tympanic membrane in 0.9% in the control group and 3.2% in the test group. Continued investigations are necessary to elucidate whether tympanometry should be part of the daily routine in general practice.

title: [Diagnosis and treatment of XXXX in general practice. A controlled trial of the effect of the introduction of middle ear measurement (tympanometry)].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute otitis media']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity2171 :: ('MESH:D010034', 'Disease') :: ['Secretory otitis media']

entities_list: @entity2169 :: ('MESH:D004427', 'Disease') :: ['diseases of the ear in general practice']

answer: @entity2169 :: (MESH:D004427,Disease) :: ['ear diseases']


abstract: BACKGROUND: @entity4149 kinase inhibitors (TKIs) are associated with prolongation of the QTc interval on the electrocardiogram (ECG). The @entity1162 increases the risk of life-threatening @entity943 . However, studies evaluating the effects of TKIs on QTc intervals are limited and only consist of small @entity1 numbers. METHODS: In this multicentre trial in four centres in the Netherlands and Italy we screened all @entity1 who were treated with any TKI. To evaluate the effects of TKIs on the QTc interval, we investigated ECGs before and during treatment with @entity3866 , @entity4562 , @entity2213 , @entity9433 , @entity6219 , @entity2857 , @entity2240 , or @entity5457 . RESULTS: A total of 363 @entity1 were eligible for the analyses. At baseline measurement, QTc intervals were significantly longer in females than in males (QTcfemales=404   ms vs QTcmales=399   ms, P=0.027). A statistically significant increase was observed for the individual TKIs @entity2240 , @entity5457 , @entity2857 , @entity2213 , and @entity3866 , after the start of treatment (median   QTc ranging from +7 to +24   ms, P<0.004). The CTCAE grade for QTc intervals significantly increased after start of treatment (P=0.0003). Especially @entity1 who are treated with @entity5457 are at increased risk of developing a QTc of    470   ms, a threshold associated with an increased risk for @entity943 . CONCLUSIONS: These observations show that most TKIs significantly increase the QTc interval. Particularly in @entity5457 -treated @entity1 , the incidence of @entity1 at risk for @entity943 is increased. Therefore, especially in case of combined risk factors, ECG monitoring in @entity1 treated with TKIs is strongly recommended.

title: Incidence and relevance of XXXX caused by @entity4149 kinase inhibitors.

entities_list: @entity6219 :: ('MESH:C516667', 'Chemical') :: ['pazopanib']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

entities_list: @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib']

entities_list: @entity5457 :: ('MESH:C551177', 'Chemical') :: ['vemurafenib']

entities_list: @entity9433 :: ('MESH:C490728', 'Chemical') :: ['lapatinib']

entities_list: @entity2857 :: ('MESH:C471405', 'Chemical') :: ['sorafenib']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['QTc-interval prolongation']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib']

entities_list: @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib']

answer: @entity1162 :: (MESH:D008133,Disease) :: ['QTc-interval prolongation']


abstract: PURPOSE OF REVIEW: This review summarizes current knowledge on the contribution of mesenteric adipose tissue in intestinal @entity32 . We will describe the cellular and humoral characteristics of creeping fat, their potential impact for @entity30 and propose a working model for the critical interplay between the creeping fat and the inflamed intestine. RECENT FINDINGS: Creeping fat can be distinguished from healthy adipose tissue by its distinctively small adipocytes, by a specific microenvironment defined by high levels of adipokines and by a dominant immune cell infiltration. In @entity30 facilitates increased bacterial translocation into the creeping fat. Translocalizing antigens can directly activate (pre)adipocytes via innate receptors. Adipocyte-derived mediators modulate phenotype and function of innate and adaptive immune cells. Activated (pre)adipocytes and adipokine-modulated immune cells might support a degree of inflammatory activation within the creeping fat that allows competent immune defense against exogenous factors while preventing systemic @entity32 . SUMMARY: Fat tissue as an active organ in health and disease has been ignored for too long. The last few years of research provided evidence for the complex metabolic and immunological functions of adipose tissue. On the basis of the available data, creeping fat in @entity30 exerts a protective function by a localized anti-inflammatory effect, thus preventing a systemic inflammatory response.

title: Role of fat and adipokines in intestinal XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease transmural inflammation", "Crohn's disease"]

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: We sought to determine whether neonatal @entity35 that sustain unilateral @entity2806 or excitotoxic insults (1) manifest contralateral @entity51 during development or in adulthood and (2) recover from those deficits. Seven-day-old (P7) @entity35 received a right intrastriatal injection of the @entity2227 analog @entity1024 ( @entity143 ). @entity519 - @entity63 (HI) was induced by right carotid ligation followed by 1.5 h in 8% O2. Both procedures produce @entity528 in the striatum and sensorimotor cortex. Nonlesioned controls were included. We scored percent forepaw placement on the edge of a horizontal surface, with lateral vibrissa stimulation, from P9 to P19, and at P33 and P50. Then, on P50, @entity35 were treated with the @entity143 antagonist @entity3390 to determine whether deficits could be reinstated. @entity143 - and HI-lesioned @entity35 exhibited a deficit in contralateral vibrissa-stimulated forepaw placing that emerged during the second week of life. Yet, by P33 and P50, the lesioned groups and controls were indistinguishable. @entity3390 injection on P50 resulted in transient reinstatement of the placing deficit. After unilateral neonatal excitotoxic or HI @entity1545 , contralateral @entity51 are detected, but in many animals, these deficits have resolved by adulthood. Thus, timing of sensorimotor tests may influence their sensitivity for detection of focal neuropathology originating in the neonatal period.

title: Early appearance of functional deficits after neonatal excitotoxic and @entity63 : fragile recovery after development and role of the XXXX receptor.

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity1024 :: ('CHEBI:31882', 'Chemical') :: ['N-methyl-D-aspartate']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral hypoxic-ischemic']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['sensorimotor deficits']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['Unilateral hypoxia']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']

answer: @entity143 :: (CHEBI:6121,Chemical) :: ['NMDA']


abstract: The objective of the present study was to evaluate the activity and the @entity137 of an original combination of @entity1311 ( @entity1311 ), @entity1260 , and @entity3003 in @entity1 with stage IIIB-IV @entity1149 ( @entity1149 ). Sixty-one @entity1 with previously untreated stage IIIB-IV @entity1149 were enrolled by five institutions. @entity1311 was given at the dose of 200 mg/m iv in 3 hours, @entity1260 (with mesna) at the dose of 3 g/m and @entity3003 at an area under the curve 5, on day 1, every 21 days for a total of six cycles in responding or stabilized @entity1 . Among the 59 @entity1 evaluable for response, 2 complete remissions and 25 partial remissions were achieved for an overall response rate of 45.7% (95% CI = 32.7-59.2). According to an intention-to-treat analysis, the response rate was 44.2%. Thirteen @entity1 had a stable disease, whereas 19 progressed. The median time to progression was 7.7 months (range: 1-18), whereas the median overall survival was 10 months (range: 1-30+). The 1-year survival rate was 43%. @entity1503 was exceptionally mild, and peripheral @entity137 of grade III was experienced by only three @entity1 . There was one @entity137 . This original triplet regimen based on @entity1311 , @entity1260 , and @entity3003 has proved active, safe, and easy to deliver on an outpatient basis for @entity1 with advanced @entity1149 . Randomized studies both versus @entity3003 - @entity1311 and other triplets are clearly warranted.

title: Phase II study of Taxol combined With @entity1260 and XXXX in the treatment of stage IIIb-IV @entity1149 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxic death', 'neurologic toxicity']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Paclitaxel', 'Taxol']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Hematologic toxicity']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: AIMS: To report outcome and urodynamic follow-up of incontinent ileovesicostomy in @entity1688 @entity1 with @entity1494 . METHODS: Seven @entity1 (five male, two female; mean age, 33.7 yr) with @entity1494 underwent ileovesicostomy for management of leakage or complications of chronic catheter drainage. Five had chronic indwelling catheters: three suprapubic and two urethral. Preoperatively, all had upper tract evaluation and videourodynamics. All seven @entity1 had @entity427 . Preoperative detrusor leak point pressures averaged 42.7 cm @entity2507 . Two females had intrinsic sphincteric deficiency from prolonged Foley catheter drainage. Ileovesicostomy involves isolation of a 15-20-cm segment of terminal ileum. The proximal 6-8 cm of this segment is opened on the antimesenteric border. The dome of the bladder is opened widely in a transverse manner and the proximal portion of the bowel is sutured onto the bladder. The distal portion of the ileum remains tubularized and becomes the stoma. RESULTS: There were no intraoperative complications. Operative time averaged 159 minutes. Associated procedures included removal of @entity3226 (n = 1), pubovaginal sling (n = 2), and Marshall Marchetti Krantz suspension (n = 1). Mean @entity190 was <200 cc in six @entity1 . Mean hospital stay was 8 days. Complications in two @entity1 included: @entity850 requiring stoma revision (n = 1), wound @entity281 (n = 1), and @entity86 (n = 1). Mean follow-up was 37.4 months. Postoperatively, mean detrusor leak point pressures were 16.7 cm @entity2507 (P = 0.0061). @entity1 satisfaction is high with only one complaint of occasional difficulty fitting the appliance. CONCLUSIONS: Ileovesicostomy is an effective method of urinary drainage in @entity1688 @entity1 . Detrusor leak point pressures were lowered, and upper tracts were preserved. No long-term complications were encountered.

title: Incontinent ileovesicostomy in the management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriplegic']

entities_list: @entity3226 :: ('MESH:D001744', 'Disease') :: ['bladder calculus']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['neurogenic bladder']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative ileus']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['fascial stenosis']

entities_list: @entity427 :: ('MESH:D012021', 'Disease') :: ['detrusor hyperreflexia']

answer: @entity1494 :: (MESH:D001745,Disease) :: ['neurogenic bladder dysfunction']


abstract: BACKGROUND: To summary the procedure and experience of a novel surgical management for @entity4810 secondary to midline @entity1069 (MPC). METHODS: From February 2012 to February 2014, 12 @entity1 were diagnosed with @entity35477 by semen analysis, seminal plasma biochemical analysis, transrectal ultrasonography (TRUS), and pelvic magnetic resonance imaging (MRI). All @entity1 underwent the transurethral unroofing of MPC using resectoscope, the dilation of ejaculatory duct, and the irrigation of seminal vesicle using seminal vesiculoscope. All @entity1 were followed up at least 3 months after operation. RESULTS: Preoperative semen analyses of 12 @entity1 showed oligoasthenozoospermia (5/12) or @entity3893 (7/12), low semen volume (0-1.9 mL), and low pH level (5.5-7.0). Preoperative seminal plasma biochemical analyses showed reduced semen @entity948 . TURS and MRI revealed a @entity8 located in the midline of prostatic. After 3 months follow up, the semen quality of 80% @entity1 (4/5) with oligoasthenozoospermia improved obviously. The spermatozoa were present in the semen in 5 of 7 cases with @entity3893 . In one @entity1 , the spermatozoa occurred in the urine after ejaculation. CONCLUSIONS: Surgical management using transurethral resectoscopy and seminal vesiculoscopy is effective, minimally invasive, and safe for @entity4810 secondary to MPC.

title: A novel surgical management for XXXX secondary to midline @entity1069 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['cyst lesion']

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatic cyst']

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility']

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose']

entities_list: @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']

answer: @entity4810 :: (MESH:D007248,Disease) :: ['male infertility']


abstract: AIMS/HYPOTHESIS: @entity3695 secretion is often reduced in @entity1723 , but little is known about the mechanism involved. Since changes in the hormonal environment modulate cell proliferation, @entity204 and cellular makeup of the anterior pituitary, we have analysed whether the number of lactotrophs is reduced in @entity6 @entity35 . METHODS: @entity3839 induced @entity6 @entity35 were maintained hyperglycaemic for 2 months. Pituitary @entity3695 , @entity11249 , @entity1976 , @entity2310 and PCNA concentrations were analysed by western blot analysis. In situ hybridisation was used for quantification of @entity3695 and @entity11249 mRNA containing cells. Cell @entity204 was detected by TUNEL labelling, alone and in combination with immunocytochemistry for @entity3695 or @entity11249 . RESULTS: @entity6 @entity35 had fewer lactotrophs ( p<0.01). This was coincident with a decrease in overall protein and @entity3695 content. An increase in pituitary cell @entity204 was found and some of the TUNEL labelling co-localised with @entity3695 immunostaining. No change in the concentration of @entity1976 or @entity2310 , proteins implicated in apoptosis, was detected. @entity63869 content was higher in the pituitaries of @entity6 @entity35 , suggesting increased proliferation. CONCLUSION/INTERPRETATION: Anterior pituitary cell turnover is affected in poorly controlled @entity6 . A decrease in the number of lactotrophs, as a result of increased cell @entity204 , could underlie, at least in part, the reduction in @entity3695 secretion observed in @entity6 animals.

title: The number of lactotrophs is reduced in the anterior pituitary of @entity3839 -induced @entity6 XXXX .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetic', 'diabetes mellitus']

entities_list: @entity3839 :: ('MESH:D013311', 'Chemical') :: ['Streptozotocin']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['insulin dependent diabetes mellitus']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: To evaluate the clinical application of preoperative aspects and dimensions used for anatomical (PADUA) scoring system in predicting perioperative surgical outcomes in @entity1 undergoing laparoscopic cryoablation (LCA). METHODS: A total of 95 consecutive @entity703 treated with LCA between January 2007 and April 2013 were collected. @entity703 were categorized into low- (6-7), moderate- (8-9), and high-complexity (10-13) groups according to PADUA indices. Demographics, perioperative variables, and complication rates were compared among three groups. Surgical conversion, @entity190 >100  mL, @entity5 fracture, and incomplete ablation were regarded as intraoperative complications (IOCs). All @entity260 ( @entity260 ) were graded using the Clavien-Dindo system. The risk for complications was assessed by univariate and multivariate logistic regression analyses. RESULTS: The estimated @entity190 during LCA was associated with PADUA score. There were 17 (17.9  %) IOCs and 20 (21.1  %) @entity260 . @entity190 (>100  mL) was the most common IOC, which occurred in 10 (10.5  %) @entity1 . For POC, there were 15 (15.8  %) minor complications (Clavien 1-2) and 5 (5.3  %) major complications (Clavien 3a). Higher grade of PADUA scores was significantly correlated with the increase incidence of IOC and POC. The PADUA score was an independent predictive factor for POC, and the @entity1 with moderate and high PADUA scores had an over sixfold and 17-fold higher risk compared to the @entity1 with low scores, respectively. CONCLUSION: Our findings demonstrated, for the first time, the PADUA scoring system is an efficient assessment tool for predicting the perioperative complications in @entity1 undergoing @entity8 .

title: The application of PADUA scoring system for predicting complications of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['laparoscopic renal cryoablation']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'Blood loss']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['POCs', 'postoperative complications']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumors', 'Renal tumors']

answer: @entity8 :: (MESH:D007674,Disease) :: ['laparoscopic renal cryoablation']


abstract: OBJECTIVE: To evaluate the change in @entity1032 after translabyrinthine @entity5513 excision. STUDY DESIGN: Prospective administration of the Dizziness Handicap Inventory preoperatively and at 3 and 12 months postoperatively; retrospective review of case notes. SETTING: A tertiary referral neuro-otology clinic. @entity1 : A total of 100 consecutive @entity1 who had @entity5513 excised between June 1998 and November 2001 and who had completed Dizziness Handicap Inventories preoperatively and at 3 and 12 months postoperatively. INTERVENTIONS: Translabyrinthine excision of a unilateral sporadic @entity5513 ; preoperative and postoperative generic vestibular rehabilitation exercises. MAIN OUTCOME MEASURES: Dizziness Handicap Inventory scores. RESULTS: For most @entity1 , @entity1032 does not worsen postoperatively. However, for those in whom it does, @entity1032 becomes significantly worse between preoperative and 3-month postoperative time points but then does not continue to decline. @entity5 size, sex, and magnitude of preoperative canal paresis significantly affect the degree of change in handicap. Age, the presence of central vestibular system abnormalities, and the nature of the @entity1 's principal presenting symptom have no effect on this handicap change. CONCLUSIONS: These findings help the clinician in counseling the @entity1 preoperatively about @entity1032 to be expected postoperatively. In particular, the clinician is now able to take an informed and positive stance in the event of a severe canal paresis preoperatively.

title: Change in @entity1032 after XXXX excision.

entities_list: @entity5513 :: ('MESH:D009464', 'Disease') :: ['vestibular schwannomas', 'vestibular schwannoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['dizziness handicap']

answer: @entity5513 :: (MESH:D009464,Disease) :: ['vestibular schwannoma']


abstract: AIM: To compare outcomes of single-fraction and multi-fraction stereotactic ablative body radiotherapy (SABR) for pulmonary @entity3 . MATERIALS AND METHODS: A retrospective review from two academic institutions of @entity1 with one to three pulmonary @entity3 staged with @entity419 positron emission tomography/computed tomography (FDG-PET/CT) scans. For single-fraction SABR, 26Gy was prescribed for peripheral targets and 18Gy for central targets. In the multi-fraction cohort, 48Gy/4 or 50Gy/5 was prescribed for peripheral targets and 50Gy/5 was prescribed for central targets. Three-dimensional conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans were delivered using heterogeneity corrections. Conformity indices at an intermediate dose (R50%) and at a high dose (R100%) were used to assess a relationship with the planning target volume ( @entity343 ). Overall survival, local and distant progression and @entity137 rates were analysed from the date of treatment completion. RESULTS: Between February 2010 and June 2013, 65 @entity1 with 85 pulmonary @entity3 were reviewed. The median follow-up was 2.1 years. @entity3 most commonly originated from @entity14 (31%), followed by @entity1149 (25%). 3D-CRT was used in 52 targets, IMRT in 21 and VMAT in 12. 3D-CRT showed a lower median R50% (P  =  0.01), but a higher median R100% than IMRT/VMAT (P  =  0.04). The R50% index was inversely correlated to the @entity343 with all techniques (P  =  0.01). Overall survival at 1 and 2 years in all @entity1 was 93% (95% confidence interval 87-100%) and 71% (95% confidence interval 58-86%), respectively. The 2 year freedom from local and distant progression was 93% (95% confidence interval 86-100%) and 38% (95% confidence interval 27-55%), respectively. There were no significant differences between overall survival (P  =  0 .14), time to distant progression (P  =  0.06) or @entity137 rates (P  =  0.75) between single- and multi-fraction cohorts. CONCLUSION: We report comparable local control, overall survival and @entity137 rates between single-fraction and multi-fraction SABR treatments in @entity1 with FDG-PET-staged pulmonary oligometastases. We propose a guideline for R50% conformity incorporating 3D-CRT/IMRT/VMAT techniques with heterogeneity corrected planning algorithms.

title: Comparison of Single-fraction and Multi-fraction Stereotactic Radiotherapy for XXXX with @entity419 Positron Emission Tomography-staged Pulmonary Oligometastases.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18)F-fluorodeoxyglucose']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastases']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: @entity1 with @entity0 sometimes present with increased liver enzymes during follow-up period that may be consistent with @entity1560 . This effect known as @entity1561 may be associated with the malignancy itself, drugs or some other well-known risk factors that may induce @entity1560 . We studied the influences of @entity66 and treatment on @entity1560 in @entity1 with @entity0 . MATERIALS AND METHODS: There were four groups of @entity1 in our study. Group 1: 40 newly diagnosed, previously untreated @entity0 ; Group 2: 45 cases of @entity0 treated with systemic therapy; Group 3: 40 cases of @entity43 ; Group 4: 40 healthy @entity1 . @entity1560 was evaluated by sonography by two radiologist, independently. We also evaluated major risk factors, biochemical findings, and influences of treatment on @entity1560 . RESULTS: We detected @entity1560 in 63%, 72%, 77%, and 48% of @entity1 in groups 1, 2, 3, and 4, respectively. There was a statistically significant difference only between groups 3 and 4 (P = 0.045). However, grade 2 and 3 @entity1560 were more frequent in @entity0 @entity1 (group 1 and 2), compared with mild @entity1560 in @entity43 @entity1 and healthy @entity1 . Although a good correlation was found between @entity440 use and chemotherapy on development of @entity1561 , no association of @entity1560 with transaminase levels was found, which might be of help for earlier detection of @entity1560 . AST/ALT ratio was found to have no impact on the rate of @entity1560 , contrary to the literature. CONCLUSION: @entity1560 , excluding @entity1 with grade 1 @entity1560 , which may be a normal variant, were more readily detected in @entity1 with @entity0 . This effect was aggravated by use of @entity440 , but not the chemotherapy. @entity1561 in @entity1 with @entity0 may be associated with the @entity5 itself or some well-known risk factors such as @entity28 , @entity407 , and @entity6 , which needs to be explored.

title: A case-control study of @entity1561 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['hepatic steatosis', 'Hepatic steatosis', 'steatosis']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity1561 :: ('MESH:D065626', 'Disease') :: ['non-alcoholic fatty liver disease', 'Non-alcoholic fatty liver disease']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: A favourable course of @entity30 has been observed after allogeneic bone marrow transplantation. and there is now mounting evidence that autologous stem cell may be an effective treatment for severe @entity792 . Here, we present the first long-term endoscopic follow-up of a @entity1 with @entity30 undergoing autologous stem cell transplantation for @entity66 . A 54-year-old @entity1 developed @entity30 and was submitted to ileocaecal resection. Four months after surgery, the @entity1 contracted @entity3052 . She was initially treated with chemotherapy, and subsequently underwent autologous stem cell transplantation. Following transplantation, the @entity1 has remained in clinical remission regarding both diseases, without anti-inflammatory medication. She has undergone ileo-colonoscopy with normal findings at 1, 2, 3 and 5 years after transplantation. This case suggests that autologous stem cell transplantation can change not only the clinical course, but also the natural history of @entity32 in @entity30 . This has pathophysiological as well as therapeutic implications.

title: Long-term endoscopic remission of XXXX after autologous stem cell transplantation for @entity3052 .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['intestinal inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['haematological disease']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukaemia']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ['Crohn disease']

answer: @entity30 :: (MESH:D003424,Disease) :: ['crohn disease']


abstract: To explore the role of @entity1533 genes in the development of @entity309 ( @entity309 ) and the correlations between HLA-DR alleles and clinical manifestations of @entity1 with @entity309 we studied 86 @entity1 and 106 race matched controls in whom HLA-DR typing was performed by the method of DNA amplification with sequence-specific primers (PCR-SSP). The subtypes of HLA- @entity4107 were determined by the method of hybridization of PCR products with sequence-specific oligonucletides (PCR-SSO). The absence or presence of HLA- @entity4107 and its subtypes was evaluated with the clinical and serological characteristics of the @entity1 . Compared with controls, an increased gene frequency of HLA- @entity4107 (48.8% vs 17.9%, P < 0.001) and a decreased frequency of HLA-DR5 (16.3% vs 27.4%, P = 0.06) were found. The @entity1533 * 0405 accounted for 61.9% of @entity4107 + @entity309 @entity1 and 21.1% of DR+4 controls (P < 0.01). There was no difference between the @entity4107 + and @entity4107 - @entity1 with respect to age, sex, duration of disease, extra-articular manifestations including @entity10632 . But rheumatoid factor (RF) was associated with HLA- @entity4107 (P < 0.05). According to the X-ray stage, the @entity1 of @entity4107 + were more severe than those of @entity4107 - (P < 0.05). HLA- @entity4107 and @entity4107 subtype of @entity1533 * 0405 were related to the development of @entity309 in Chinese. HLA- @entity4107 can be a useful prognostic marker in the @entity1 with @entity309 .

title: [ @entity1533 alleles genotyping in @entity1 with XXXX in Chinese].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity10632 :: ('MESH:D012859', 'Disease') :: ["secondary Sjogren's syndrome"]

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: @entity1082 ) is considered to be an etiologic agent of cervical @entity5 and, recently its relation to oral and @entity5 has also been investigated. @entity957 (SCC) represents 90% of all @entity5 that affect the oral cavity. The prevalence of HPV in @entity1 with SCC ranges from 0 to 100%. The most known viral cytopathic effect is koilocytosis, considered to be a major characteristic of @entity1083 . AIM: The aim of this study was to verify the prevalence of some peculiar characteristics of HPV--koilocytosis--in oral and oropharyngeal SCC. STUDY DESIGN: Transversal cohort. MATERIAL AND METHOD: Twenty slides with oral and/or oropharyngeal SCC were examined under microscopy. RESULTS: In 15 of them, koilocytosis was found, amounting to 75%. Although we know that polymerase chain reaction (PCR) is the method with the best sensitivity for HPV detection, we began this research looking for koilocytosis, which is highly suggestive of @entity1083 . CONCLUSION: This study is a trial project and we will continue this research with PCR measures to confirm this high prevalence of @entity1083 in oral and oropharyngeal SCC.

title: Prevalence of histological findings of XXXX ) in oral and @entity957 biopsies: preliminary study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumors', 'cancer', 'oropharyngeal cancer']

entities_list: @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['Oral squamous cell carcinoma']

entities_list: @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus (HPV']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus (HPV']


abstract: OBJECTIVE: To observe the effect of Astragalus-Angelica Mixture (AAM) on osteopontin (OPN) expression in @entity35 with chronic @entity9161 . METHODS: Chronic @entity9161 model @entity35 induced by repeated intraperitoneal injection of @entity5808 were randomly divided into the model group, AAM group and @entity7056 (an antagonist of angiotensin) group. The experimental course lasted 12 weeks. Blood and urine samples were examined by biochemical method. Kidney tissue was taken for pathological stain and immunohistochemical method and was applied to examine OPN expression, mononuclear macrophage, laminin in extracellular matrix and decorin expressions. RESULTS: AAM showed the effects of decreasing urinary protein and improving renal function similar to that of @entity7056 . It also could alleviate the pathological damage of kidney tissue, especially in decreasing renal tubular mesenchymal damage index. The accumulation of decorin and laminin in the mesenchymal extracellular matrix significantly decreased. Renal tubular OPN expression and mesenchymal infiltration of mononuclear macrophage decreased significantly and in a positive correlated manner (r = 0.885, P < 0.01). CONCLUSION: AAM has similar renal protective action to that of @entity7056 , this action may be related to the inhibition of up-regulated OPN expression.

title: [Effect of astragalus-angelica mixture on osteopontin expression in @entity35 with chronic XXXX ].

entities_list: @entity9161 :: ('MESH:D009400', 'Disease') :: ['nephrosclerosis']

entities_list: @entity7056 :: ('MESH:C081309', 'Chemical') :: ['Irbesartan']

entities_list: @entity5808 :: ('MESH:D011691', 'Chemical') :: ['puromycin']

answer: @entity9161 :: (MESH:D009400,Disease) :: ['nephrosclerosis']