abstract: This study investigated the effect of a maxillary fixed lingual arch with anterior bite plane on adult @entity1 with @entity11158 ( @entity11158 ) and @entity2632 . The sample comprised 11 @entity1 with an @entity2632 (greater than 5 mm) and a normal or Class II molar relationship. The main @entity11158 symptoms were daily tension @entity10 in the region of anterior temporal muscles and/or @entity158 or clicking in the temporomandibular joint. Previous treatment with stabilization splints, @entity8976 , or occlusal grinding had not given satisfactory results. When the maxillary lingual arch with anterior bite plane was fitted, molar separation was approximately 4 mm, and occlusal contact occurred only between the acrylic bite plane and the lower six anterior @entity4500 . The permanent appliance could be removed only by the orthodontist. All @entity1 reported relief of @entity11158 symptoms 1 to 2 weeks after initiation of treatment. After a mean time of 3 months, a flatter curve of Spee, molar contact, and @entity2632 could be seen in all cases. The excessive overbite had decreased approximately 3.4 mm. Subsequent treatment involved orthodontic or prosthetic therapy to normalize and stabilize the sagittal and vertical dimensions. After an average posttreatment observation period of 2 years, all @entity1 remained free of @entity2531 .

title: XXXX and @entity11158 --a clinical approach.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8976 :: ('MESH:D001733', 'Disease') :: ['removal bite plates']

entities_list: @entity2632 :: ('MESH:D057887', 'Disease') :: ['reduced overbite', 'increased overbite']

entities_list: @entity11158 :: ('MESH:D017271', 'Disease') :: ['CMD', 'craniomandibular disorders']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity2632 :: (MESH:D057887,Disease) :: ['Increased overbite']


abstract: PURPOSE: We assessed the @entity263 detection rate of real-time elastography targeted biopsy in @entity1 with total @entity1486 1.25 ng/ml or greater and 4.00 ng/ml or less. MATERIALS AND METHODS: Real-time elastography using an EUB 8500 Hitachi ultrasound system (Hitachi Medical, Tokyo, Japan) was done in 94 @entity1 with a mean age of 57.4 years (range 35 to 77) with increased @entity1486 between 1.25 ng/ml or greater and 4.00 ng/ml or less (mean 3.20, range 1.30 to 4.00) and a free-to-total @entity1486 ratio of less than 18%. Real-time elastography was done to evaluate peripheral zone tissue elasticity and hard areas were defined as suspicious. Targeted biopsies with a maximum of 5 cores were done in suspicious areas, followed by 10-core systematic biopsy. We analyzed the @entity5 detection rate of real-time elastography and systematic biopsy. RESULTS: @entity5 was found in 27 of 94 @entity1 (28.7%). Real-time elastography detected @entity5 in 20 @entity1 (21.3%) and systematic biopsy detected it in 18 (19.1%). Positive @entity5 cores were found in real-time elastography targeted cores in 38 of 158 cases (24%) and in systematic cores in 38 of 752 (5.1%) (chi-square test p <0.0001). The @entity5 detection rate per core was 4.7-fold greater for targeted than for systematic biopsy. CONCLUSIONS: Real-time elastography targeted biopsy allows @entity263 detection in @entity1 with @entity1486 1.25 ng/ml or greater and 4 ng/ml or less with a decreased number of cores compared with that of systematic biopsy.

title: Value of real-time elastography targeted biopsy for @entity263 detection in @entity1 with XXXX 1.25 ng/ml or greater and 4.00 ng/ml or less.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']

answer: @entity1486 :: (354,Gene) :: ['prostate specific antigen']


abstract: Intracellular recordings were made from 168 sympathetic preganglionic neurons in the slice of the second or third thoracic spinal-cord segment of the adult cat to study the actions of @entity1063 on these neurons. @entity1063 , applied by superfusion (0.5-50 microM), produced membrane depolarization in 73 neurons and membrane hyperpolarization in 39 neurons. In 26 neurons @entity1063 produced a biphasic response (depolarization-hyperpolarization or vice versa). The depolarization was blocked by @entity3159 , while the hyperpolarization was blocked by @entity3160 . The @entity1063 -induced depolarization was associated with an increase in neuron input resistance, while the @entity1063 -induced hyperpolarization was associated with a decrease in neuron input resistance. Both responses decreased in amplitude with membrane hyperpolarization and were nullified at around the @entity972 equilibrium potential EK. The null potential of both responses became more and less negative with a decrease and an increase, respectively, in the extracellular @entity972 concentration. When the membrane potential was made more negative than EK, the @entity1063 -induced hyperpolarization reversed to depolarization in all cases, whereas in only 4 of 12 cases did the @entity1063 -induced depolarization reverse to hyperpolarization. These data suggest that the @entity1063 -induced depolarization is a result of a decrease, while the @entity1063 -induced hyperpolarization is a result of an increase in K+ conductance. @entity1953 (2 mM), low @entity460 --high @entity1760 , and intracellular @entity4527 markedly reduced or abolished the @entity1063 -induced depolarization but had no significant effect on the @entity1063 -induced hyperpolarization. Barium (2 mM) depressed both responses. @entity5128 (10-30 mM), @entity973 (3 mM), and @entity5166 (2 mM) had no effect on either response.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Adrenergic receptors (alpha 1 and alpha 2) modulate different XXXX conductances in sympathetic preganglionic neurons.

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

entities_list: @entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine']

entities_list: @entity5128 :: ('MESH:D019789', 'Chemical') :: ['Tetraethylammonium']

entities_list: @entity973 :: ('MESH:D015761', 'Chemical') :: ['4-aminopyridine']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity3159 :: ('MESH:D011224', 'Chemical') :: ['prazosin']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['Noradrenaline', 'noradrenaline']

answer: @entity972 :: (MESH:D011188,Chemical) :: ['potassium']


abstract: INTRODUCTION: For one decade, the minimally invasive technique (MIRPE) of Nuss has been used in our Service as the elective technique for correction of Pectus Excavatum. If recurrences occur in @entity1 that underwent open surgery, a new surgery of the same characteristics entails important technical problems, long surgical times and poor outcome. For this reason, we think that one specific indication for the MIRPE technique may be this type of @entity1 . MATERIAL AND METHODS: Based on our experience with four @entity1 with a recurrence of @entity1408 after an open surgery "Ravitch type", we illustrate the fundamental aspects for the development of the Nuss technique, adapted to this type of @entity1 . The factors to be consider are: Systematic bilateral thoracoscopy with a suitable position of the two towers to guarantee a good visualisation of the passage of the introducer clamp by the mediastino. Use of thoracoscope with work channel on the right side, that allows the releasing of adherences and with a 5 mm lens on the left side. Use of a large introducer clamp more length for adolescent @entity1 , The rest of the material is the usual one in this protocol surgery. Our @entity1 did not present any remarkable incidences, with very satisfactory results. COMMENTS AND CONCLUSIONS: We found of great importance for the good development of the technique to establish a correct strategy prior to surgery and to dispose a good organisation of the surgery room. The surgery must be carried out in a spacious surgical room, given the great amount of material that is used. It is important to be familiarized with the procedure, because even if performed in a regulated way, variations in the positioning and fixation of the bar are frequently needed.

title: [Correction of recurrent XXXX post-Ravitch with the Nuss technique].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1408 :: ('MESH:D005660', 'Disease') :: ['pectus excavatum']

answer: @entity1408 :: (MESH:D005660,Disease) :: ['pectus excavatum']


abstract: OBJECTIVE: The sentinel node concept is of great value in the treatment of various @entity5 . In this study we investigated whether the application of the sentinel node procedure is feasible in @entity420 and whether it can tailor surgical treatment of the individual @entity1 . METHODS: In 40 @entity1 with an @entity420 of the distal esophagus or gastroesophageal junction, blue dye was injected around the @entity5 intraoperatively. Sentinel nodes (blue-stained) and nonsentinel nodes were identified and dissected during transhiatal esophagectomy. In sentinel nodes negative for @entity5 cells on routine @entity1710 - @entity1711 examination, multilevel sectioning and immunohistochemical staining were performed to search for micrometastases. RESULTS: The sentinel node procedure was technically successful in 39 of 40 @entity1 (98%). The median number of sentinel nodes identified was 4. Sentinel nodes were present in more than 1 nodal station in 8 @entity1 (21%). In 6 @entity1 in whom the sentinel node was negative for @entity3 , nonsentinel nodes were positive for @entity5 cells (false-negative rate 6/39 = 15%). Micrometastases and @entity5 cells were detected in 7 of 19 @entity1 (37%) with sentinel nodes, but this finding did not affect the false-negative rate. CONCLUSION: Detection of sentinel nodes is technically feasible during esophagectomy for @entity5 . However, given the relatively high false-negative rate of 15% and the high frequency of sentinel nodes in more than 1 nodal station, the clinical relevance of the sentinel node concept (through application of the blue dye technique) in the current treatment of @entity1 with an @entity420 of the distal esophagus or gastroesophageal junction seems limited.

title: The sentinel node concept in XXXX of the distal esophagus and gastroesophageal junction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'isolated tumor', 'cancer', 'malignancies']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma', 'adenocarcinoma']

answer: @entity420 :: (MESH:D000230,Disease) :: ['adenocarcinomas']


abstract: BACKGROUND: @entity1117 ( @entity1117 ) is a rare @entity74 resulting in an increased susceptibility to @entity281 including @entity364 ( @entity364 ) and inflammatory complications. This study is aimed at assessing the incidence, prevalence, and outcome of @entity364 among @entity1117 @entity1 followed in France. METHODS: @entity1117 @entity1 were identified through the French national registry for @entity465 ( @entity465 ) held by the French national reference Centre of @entity465 (Centre de R  f  rence D  ficits Immunitaires H  r  ditaires), which comprises a total of 3083 @entity1 including 155 with @entity1117 followed between 1976 and 2008. A questionnaire was filled out for each episode of @entity4329 . Information retrieved included a description of the @entity4329 using the 2008 European Organization for Research and Treatment of @entity5 /Mycoses Study Group @entity4329 definition criteria. RESULTS: Of @entity1117 @entity1 , 42.6% (66/155) developed at least 1 episode of @entity4329 . Overall incidence of @entity4329 was 0.040/ @entity1 -years (1862 @entity1 -years of total follow-up). @entity4329 incidence was found to be significant while receiving @entity2059 prophylaxis compared with no prophylaxis (0.027 vs. 0.053 @entity4329 / @entity1 -years; P < 0.01). Median age at @entity4329 diagnosis was 6.5 years (3.3-11.3). The most common fungal genus was Aspergillus sp. accounting for 40% of all @entity364 . Of the @entity364 , 42.5% were proven, 30.0% probable, and 27.5% possible. Of all @entity4329 episodes, 52.5% were treated by antifungal monotherapy, mostly by @entity2379 . Survival was reduced in @entity4329 @entity1 compared with those without it (log-rank 0.04). CONCLUSIONS: @entity364 are a frequent and life-threatening complication in @entity1117 @entity1 . @entity2059 significantly reduces its incidence and should be recommended in absence of better alternatives.

title: Epidemiology and outcome of @entity364 in XXXX with @entity1117 : a multicenter study in France.

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['invasive fungal diseases', 'IFDs']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['PID', 'primary immunodeficiencies']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited phagocytic disorder']

entities_list: @entity1117 :: ('MESH:D006105', 'Disease') :: ['Chronic granulomatous disease', 'CGD']

entities_list: @entity2059 :: ('MESH:D017964', 'Chemical') :: ['Itraconazole', 'itraconazole']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: Research on and intervention for @entity1 @entity734 and @entity146 toward @entity1 have been severely hampered because there have been no agreed-upon, clinically usable definitions. METHODS: We have (a) proposed and field-tested a set of criteria to operationally define @entity1 @entity734 for clinical settings and (b) used these criteria to design a parent-report measure of parental @entity146 and @entity1 @entity734 that could be used in research. In this paper, we review the development and field trials of these criteria for making substantiation decisions. RESULTS: Agreement between master reviewers and field decisions was extremely high in a 5-site development trial (96% agreement, k=.89) and a 41-site dissemination trial (90% agreement, k=.73). We compare these criteria to other research criteria in the literature. We then present data collected using a self-report measure designed to parallel these criteria from an anonymous online survey of US Air Force personnel and their spouses. The final sample (N=52,780) was weighted to be representative of the United States civilian population. The prevalence of parents' emotionally aggressive acts was much higher than the prevalence of @entity734 (acts plus impact), but rates of parents' acts of @entity146 were lower than those typically reported in the literature. Additional analyses tested for differential effects due to gender of perpetrator (i.e., mothers or fathers), age of victim, and clustering within families. These factors did not drive rates of @entity146 or abuse. CONCLUSIONS: In sum, the criteria developed and proposed appear to support reliable clinical decision making regarding @entity1 @entity734 and can be translated to research survey tools that better capture the continuum of parents' @entity146 and @entity1 @entity734 than the measures that are currently available, advancing the state of the science with respect to @entity1 @entity734 .

title: @entity1 XXXX and abuse: definitions and prevalence.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['emotional abuse']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['emotional aggression', 'aggression']

answer: @entity146 :: (MESH:D001523,Disease) :: ['emotional aggression']


abstract: @entity4306 ( @entity4306 ), is an autosomal dominant trait, which presents with recurrent attacks of @entity490 , and is the most common cause of chronic relapsing @entity788 in @entity1 . In addition to recurring episodes of intense @entity158 , @entity1 have @entity390 , @entity391 , and @entity448 , and typically show elevated serum amylase levels during the acute episode that can rapidly decline in convalescence. Complications of long-standing disease include features of chronic @entity788 , such as pancreatic pseudo-cyst, exocrine and endocrine failure, parenchymal calcification, and @entity788 . A large family from Virginia, which was originally studied by Katwinkle and Lapey in 1973, was re-ascertained through a new proband. Linkage studies in this family mapped the gene to the 7q35 region, with similar results being reported simultaneously by two other groups. A pathogenic G to A transition mutation in exon 3 of the @entity20618 ( @entity20618 ) gene, which had previously been mapped to this region, was found both in our family as well as other families from North America. Many other conditions can produce abdominal symptoms that are often mis-attributed to the disease in @entity4306 families. An affected member of our family in whom the mutation was confirmed by direct sequencing of exon 3 of the @entity20618 gene requested diagnostic testing on his 4-year-old son because of onset of severe @entity490 . Screening for the mutation in this @entity1 did not reveal the pathogenic G to A change. These results prevented unnecessary invasive diagnostic procedures and treatment in this @entity1 . The pre-symptomatic testing of high risk individuals could, thus, have a significant impact on the well being of both affected and normal family members.

title: Implications of molecular diagnostic testing in families with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic cancer']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity4306 :: ('MESH:C537262', 'Disease') :: ['Hereditary Pancreatitis', 'HP']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain', 'abdominal pain and vomiting']

entities_list: @entity20618 :: ('5644', 'Gene') :: ['CT', 'cationic trypsinogen']

answer: @entity4306 :: (MESH:C537262,Disease) :: ['hereditary pancreatitis']


abstract: The management of coronary @entity1 aims at improving the prognosis, by preventing @entity583 and/or @entity204 , and also at optimal reduction of symptoms related to @entity301 . This can be achieved by a variety of approaches including coronary revascularisation, life-style modifications and drug therapies including several drug classes: platelet inhibitors, beta-blockers, @entity1289 ( @entity1289 ) inhibitors, statins and anti-anginal drugs. The B.A.S.I.C. regimen is a combination of a beta-blocker, a platelet inhibitor, a statin and an @entity1289 inhibitor for secondary prevention in coronary @entity1 . Although recommended in the latest ESC and AHA/ACC guidelines, this strategy is insufficiently applied in medical practice. Indeed, the results of the European Action on Secondary Prevention by Intervention to Reduce Events (EUROASPIRE) Survey conducted over the period 1999-2000, show that 6 months after a first hospitalisation for aorto-coronary bypass, percutaneous coronary angioplasty, @entity583 or @entity1187 , 86% of @entity1 are prescribed a platelet inhibitor, 63% a beta-blocker, 61% a hypolipidaemic agent and only 38%, an @entity1289 inhibitor. The PREVENIR Study published in 2005 reported that only 12% of @entity1 are prescribed the B.A.S.I.C. quadritherapy outside the acute phase. Despite recognised benefits in terms of survival, the B.A.S.I.C. approach is therefore clearly under-prescribed following coronary events.

title: [Long-term management of coronary XXXX : current guidelines and practices].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity1289 :: ('1636', 'Gene') :: ['angiotensin converting enzyme', 'ACE']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The catabolism of @entity1 HDL was studied in @entity1 @entity157 cell line HepG2. The binding of 125I-labeled HDL at 4 degrees C was time-dependent and reached completion within 2 h. The observed rates of binding of 125I-labeled HDL at 4 degrees C and uptake and degradation at 37 degrees C indicated the presence of both high-affinity and low-affinity binding sites for this lipoprotein density class. The specific binding of 125I-labeled HDL accounted for 55% of the total binding capacity. The lysosomal degradation of 125I-labeled HDL was inhibited 25 and 60% by @entity503 at 50 and 100 microM, respectively. Depolymerization of microtubules by @entity3812 (1 microM) inhibited the degradation of 125I-labeled HDL by 36%. Incubation of cells with HDL caused no significant change in the cellular @entity165 content or in the de novo @entity5068 synthesis and @entity165 esterification. Binding and degradation of 125I-labeled HDL was not affected by prior incubation of cells with HDL. When added at the same protein concentration, unlabeled VLDL, LDL and HDL had similar inhibitory effects on the degradation of 125I-labeled HDL, irrespective of a short or prolonged incubation time. Reductive methylation of unlabeled HDL had no significant effect on its capacity to inhibit the 125I-labeled HDL degradation. The competition study indicated no correlation between the concentrations of apolipoproteins A-I, @entity5704 , C-II, C-III, E and F in VLDL, LDL and HDL and the inhibitory effect of these lipoprotein density classes on the degradation of 125I-labeled HDL. There was, however, some association between the inhibitory effect and the levels of @entity16990 and C-I.

title: Binding and degradation of @entity1 high-density lipoproteins by XXXX @entity157 cell line HepG2.

entities_list: @entity16990 :: ('347', 'Gene') :: ['apolipoprotein D']

entities_list: @entity3812 :: ('MESH:D003078', 'Chemical') :: ['colchicine']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma']

entities_list: @entity503 :: ('MESH:D002738', 'Chemical') :: ['chloroquine']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The aim of this study was to investigate the mechanisms of action of @entity36205 ( @entity4601 ), a semi-synthesized agent from the starting material @entity507 extracted from the Chinese Traditional Herbs Artemisia annua, on ameliorating the symptoms of lupus on BXSB @entity19 . The concentration of @entity637 in the culture supernatant of the peritoneal macrophages and in the sera of BXSB @entity19 was determined by the ELISA method. @entity1991 protein expression and translocation were assayed by the EMSA method and laser confocal scanning microscopy method, respectively. @entity1993 and @entity1991 @entity1992 protein expression were determined by the Western blot method. Renal tissue of the BXSB @entity19 was prepared for assaying inhibitory activity of @entity4601 on @entity1991 , @entity1992 and @entity1993 protein expression in vivo. The peritoneal macrophages were prepared for analysis inhibitory effects of @entity4601 on translocation of @entity1991 into nuclear in vitro. We found that @entity4601 strongly reduced the production of @entity637 in the culture supernatant of the peritoneal macrophages and in the sera of BXSB @entity19 in vitro or in vivo. The results demonstrated that @entity4601 decreased the expression of @entity1991 subunit @entity1992 protein and the activation of @entity1991 in the renal tissue of BXSB @entity19 in vivo. @entity4601 effectively inhibited the nuclear translocation of @entity1991 in peritoneal macrophages of BXSB @entity19 in vitro. Furthermore, it was demonstrated that the degradation of @entity1993 protein was significantly inhibited by @entity4601 . These observations suggested that the inhibitory effects of @entity4601 on @entity637 production may result from the block in the @entity1991 signaling pathway upstream of IkappaB degradation.

title: XXXX ameliorates lupus symptom of BXSB @entity19 by inhibiting production of @entity637 and blocking the signaling pathway @entity1991 translocation.

entities_list: @entity36205 :: ('MESH:C513609', 'Chemical') :: ['Dihydroarteannuin']

entities_list: @entity507 :: ('MESH:C031327', 'Chemical') :: ['artemisinin']

answer: @entity36205 :: (MESH:C513609,Chemical) :: ['Dihydroarteannuin']


abstract: UNASSIGNED: MicroRNAs (miRNAs) are small non-coding regulatory RNAs, which are involved in the post-transcriptional regulation of gene expression. @entity10015 , which has previously been reported to be @entity2 , is correlated with poor @entity1 prognosis. The present study aimed to investigate the effects of @entity10015 on the radiosensitivity of @entity1 @entity1149 ( @entity1149 ) cells. To explore the roles of miRNAs in the regulation of irradiation sensitivity of @entity1 @entity2 cells, the expressions of @entity10015 in response to irradiation, have been studied by RT  -qPCR, and the putative direct target of @entity10015 was identified by western blot and luciferase assays. The results of the present study revealed that the expression of @entity10015 was induced by irradiation, thus suggesting a positive correlation between @entity10015 and radiosensitivity. Furthermore, overexpression of @entity10015 rendered @entity2 cells resistant to irradiation. In addition, @entity26256 ( @entity26256 ) was identified as an indirect target of @entity10015 ; exogenous overexpression of @entity10015 upregulated the expression of @entity26256 , whereas inhibition of @entity10015 by antisense miRNA suppressed @entity26256 expression. In addition, @entity26256  -modulated @entity413 metabolism was significantly upregulated by overexpression of @entity10015 . Notably, inhibition of @entity10015 sensitized @entity2 cells to irradiation via suppression of @entity413 metabolism. In conclusion, the present study reported a novel function for @entity10015 in the regulation of @entity1149 cell radiosensitivity, thus suggesting that @entity10015 may be considered a therapeutic target for the development of anticancer drugs.

title: Inhibition of microRNA-155 sensitizes @entity2 cells to irradiation via suppression of @entity26256 -modulated XXXX metabolism.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'overexpressed in lung cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non  -small cell lung cancer']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: OBJECTIVE: The @entity26206 reductase gene ( @entity9769 ) has been linked to unipolar @entity308 ( @entity308 ) and magnetic resonance imaging (MRI) hyperintensities. The authors examined the relationship between the @entity9769 @entity9770 polymorphism ( @entity9770 ) and a) geriatric @entity308 , b) MRI hyperintense lesion volume, and c) neurocognitive test performance. DESIGN: Cross-sectional. SETTING: Duke University Medical Center. @entity1 : @entity308 (N = 178) and comparison (N = 85) elderly subjects. MEASUREMENTS: Subjects had blood drawn to assess @entity9769 genotype, were imaged by MRI to determine their @entity62 ( @entity62 ) and gray matter hyperintense lesion (GML) volume, and assessed using a comprehensive @entity149 evaluating multiple domains of function. Linear regression models were fit to test the effect of genotype, a @entity308 by genotype interaction, and an age by genotype interaction on both hyperintense lesion volume measures and neurocognitive task performance. RESULTS: The @entity9769 @entity9770 genotype by age interaction term was significantly associated with MRI @entity62 volume (p = 0.0175); however, this relationship was no longer statistically significant when @entity62 volumes underwent a log transformation to produce a more normal distribution. The 677T allele was neither more frequent in depressed subjects nor associated with either gray matter hyperintensity volume or neurocognitive test performance. CONCLUSIONS: @entity9769 genotype affects the relationship between age and @entity62 volume where individuals who carry the 677T allele exhibit greater @entity62 volume by age, although this relationship should be verified given the failure to replicate the finding using transformed @entity62 volumes. Genotype was not related to GML volume, cognitive function, or presence of @entity308 , although demographic differences could account for this negative finding.

title: Influence of the @entity9769 XXXX polymorphism on magnetic resonance imaging hyperintensity volume and cognition in geriatric depression.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS']

entities_list: @entity26206 :: ('MESH:C013123', 'Chemical') :: ['5,10-methylenetetrahydrofolate']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'Depressed', 'depression', 'major depressive disorder']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive battery']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['WML', 'white matter hyperintense lesion']

answer: @entity9770 :: (c|SUB|C|677|T,DNAMutation) :: ['C677T']


abstract: BACKGROUND: Certain types of @entity1082 ) can cause cervical and other @entity5 . A vaccine that protects against HPV types responsible for 70% of @entity5 is available to females ages 9-26. OBJECTIVE: To examine correlates of stage of vaccine adoption among @entity1 ages 18-22. METHODS: In 2007, female students (n=4774) at a New England University in the U.S. were invited to complete an on-line survey that assessed knowledge of HPV, perceived susceptibility, severity, vaccine benefits/barriers, social and subjective norms, and stage of vaccine adoption RESULTS: 1897 @entity1 (40%) responded; complete data were available for 1401. About half (53%) were planning to be vaccinated, 12% had received the vaccine, 15% were undecided, and 7% had decided against vaccination. HPV knowledge was low (mean 58%). In multivariate analyses, social norms was the strongest correlate of stage; each standard deviation increase in social norms score was associated with more than four times the odds of intending to be vaccinated within the next 30 days, compared with those who had decided against vaccination (OR=4.15; 95% CI 2.17-6.36). CONCLUSIONS: Acceptance of the vaccine was high, although misconceptions about viral transmission, availability of treatment, and the role of Pap tests were common. Perceived norms were strongly associated with intentions. Interventions on college campuses should stress vaccination as a normative behavior, provide information about viral transmission, and stress the role of continued Pap screening.

title: Stage of adoption of the @entity1082 vaccine among college XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancers', 'cancers']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: The aim of this study was to evaluate the safety and efficacy of @entity16495 0.2 % and @entity6839 0.5 % instillation as a fixed combination (Combigan, Allergan Inc.) to prevent @entity2790 (IOP) increase occurring after intravitreal injection of ranibizumab (Lucentis, Novartis Pharma AG). @entity1 AND METHODS: A prospective double-blind placebo-controlled study was carried out. One eye of 88 consecutive normotensive age-related @entity1020 @entity1 receiving Lucentis was randomized into placebo drops (artificial tears, 44 @entity1 ) or Combigan drops (44 @entity1 ) given twice a day the day before and the day of injection. IOP was measured before and 5, 10, 15 minutes and 1 hour after the intravitreal injection. RESULTS: The placebo group had the higher mean IOP at all time points after injection. Maximum IOP increase for both groups occurred at the 5-minutes time point. Mean post-injection IOP in the placebo group was 34.1 +/- 2.7 mmHg at 5 minutes post-injection versus 28.4 +/- 1.1 mmHg in the Combigan group (P < 0.001). IOP decreased to 24.9 +/- 1.8 mmHg (placebo group) and 19.9 +/- 1.1 mmHg (Combigan group) at 10 minutes post-injection. At 15 minutes post-injection, IOP was below 20 mmHg in all eyes of the Combigan group (100 %), whereas at the same time point these IOP levels were reached only by 34 % of the eyes of the placebo group (15 eyes). All eyes of both groups had a normal @entity26147 hour post-injection. No systemic or ocular side effect was recorded in either group. CONCLUSIONS: The use of Combigan drops twice a day the day before and the day of injection in eyes scheduled for intravitreal injection of Lucentis is a safe and effective prophylaxis to reduce the acute IOP spikes of the post-injection period.

title: Effect of @entity16495 / XXXX fixed combination on preventing the short-term intraocular pressure increase after intravitreal injection of ranibizumab.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity16495 :: ('MESH:C015620', 'Chemical') :: ['brimonidine']

entities_list: @entity2790 :: ('MESH:D009798', 'Disease') :: ['acute intraocular pressure']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration']

answer: @entity6839 :: (MESH:D013999,Chemical) :: ['timolol']


abstract: Bone marrow-derived hematopoietic stem cells (HSC) can exhibit tremendous differentiation activity in numerous non-hematopoietic organs. This enigmatic process is called as 'stem cell plasticity' ( @entity25513 ). HSC may promote structural and functional repair in several organs such as heart, liver, brain, and skeletal muscle via the @entity25513 . The differentiation capacity of HSC is dependent on the specific signals present in the local tissue microenvironment. Those specific molecular signals required for the interactions of HSC and host tissues are currently unknown. The aim of this report is to propose a hypothesis on how HSC reach, recognize, and function in cardiac tissues in the context of @entity25513 . Locally signaling cardiac microenvironment is essential for the seeding, expansion, and 'cardiomyocyte differentiation' of the HSC in the heart. Our hypothesis is that the receptors, ligands, and signaling pathways of the tissue @entity916 -angiotensin system (RAS) serve as the link between HSC and local cardiac microenvironment in @entity25513 . The RAS is considered as a 'tissue-based system' exhibiting paracrine functions within many organs. The presence of local hematopoietic bone marrow RAS and local cardiac RAS have been suggested. Both local tissue RASs share similar angiotensin peptide-signaling pathways such as JAK-STAT and mitogen-activated protein kinases. HSC have angiotensin type I (AT1a) receptors for the binding of @entity2178 , the active component of the RAS. Binding of @entity2178 to AT1a can increase hematopoietic progenitor cell proliferation. Local cardiac RAS has critical (patho)biological functions in the cardiomyocyte survival, renewal, and growth, as well as in cardiac remodeling. Therefore, the components of the local cardiac RAS and hematopoietic RAS could interact with each other during the @entity25513 through myocardial tissue repair. Activation of the local myocardial RAS after injury may be related to homing and engraftment of the HSC to the cardiac tissue. Regenerating myocardial tissue may exert regulatory functions on circulating or resident HSC via the locally active RAS. Understanding the exact molecular basis of @entity25513 in relation to local tissue RAS could offer new frontiers in the better management of @entity63 @entity299 .

title: How hematopoietic stem cells know and act in cardiac microenvironment for stem cell plasticity? Impact of local XXXX -angiotensin systems.

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity2178 :: ('183', 'Gene') :: ['angiotensin II']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases']

answer: @entity916 :: (5972,Gene) :: ['renin']


abstract: @entity2918 are known to be mediators of @entity32 in many tissues. Their fluctuations in gingival crevicular fluid during experimentally induced @entity2521 were investigated, together with the possible role of phospholipids, which were measured in normal gingiva and gingiva associated with the @entity7278 . @entity2521 was induced in 5 @entity235 in the lower premolar quadrant; the opposite quadrant was used as a control. A small amount of inter-radicular bone was removed and then a @entity2708 -wrapped stainless steel ligature was placed around each of 3 premolar teeth below the gingival margin to provide an inflammatory irritant. Pocket depth was measured by periodontal probe; crevicular fluid was collected on absorbent paper points. PGs were analysed by HPLC and the results expressed as ng PG/microliter crevicular fluid. Measurements were taken in both quadrants at 1, 3 and 6 weeks after placement of the ligatures; PGI2, 6 keto-F1 alpha, F2 alpha, E2, E1 and D2 were detected in the crevicular fluid. At 1 week, there was no difference in PG levels between experimental and control sides. During week 3, PGI2 and @entity1421 increased in the experimental crevicular fluid [214.1 +/- 49.3 (SEM) vs control 87.0 +/- 39.7; p less than 0.05 and 350.0 +/- 115 vs 162.0 +/- 14.7; p less than 0.05, respectively]. At week 6, only @entity1421 was elevated in crevicular fluid (207.7 +/- 68.1 vs 99.2 +/- 45; p less than 0.025).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Gingival crevicular fluid @entity2918 and gingival phospholipids in experimentally-induced @entity2521 in the XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis']

entities_list: @entity2918 :: ('MESH:D011453', 'Chemical') :: ['Prostaglandins']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis', 'Periodontitis']

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: @entity438 represent a significant cause of morbidity and mortality. While the risk factors for @entity439 formation are known, the detection of @entity439 remains challenging. Magnetic resonance angiography (MRA) has recently emerged as a useful non-invasive method for @entity439 detection. However, even for experienced neuroradiologists, the sensitivity to small (<5 mm) @entity439 in MRA images is poor, on the order of 30~60% in recent, large series. We describe a fully automated computer-aided detection (CAD) scheme for detecting @entity439 on 3D @entity1054 ( @entity1054 ) MRA images. The scheme locates points of interest (POIs) on individual MRA datasets by combining two complementary techniques. The first technique segments the intracranial arteries automatically and finds POIs from the segmented vessels. The second technique identifies POIs directly from the raw, unsegmented image dataset. This latter technique is useful in cases of incomplete segmentation. Following a series of feature calculations, a small fraction of POIs are retained as candidate @entity439 from the collected POIs according to predetermined rules. The CAD scheme was evaluated on 287 datasets containing 147 @entity439 that were verified with digital subtraction angiography, the accepted standard of reference for @entity439 detection. For two different operating points, the CAD scheme achieved a sensitivity of 80% (71% for @entity439 than 5 mm) with three mean false positives per case, and 95% (91% for @entity439 than 5 mm) with nine mean false positives per case. In conclusion, the CAD scheme showed good accuracy and may have application in improving the sensitivity of @entity439 detection on MR images.

title: Computer-aided detection of XXXX in MR angiography.

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'aneurysms less']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['time-of-flight', 'TOF']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['Intracranial aneurysms']

answer: @entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']


abstract: @entity8310 viruses are the causative agents of @entity8310 , an economically important contagious disease of livestock that occurs in North, Central, and South America. Little is known regarding the early stages of @entity281 in natural hosts. Twelve adult Holstein steers were inoculated with @entity8310 New Jersey virus (VSNJV) on the coronary bands (CB) of the feet via scarification (SC) or by VSNJV-infected black @entity238 (Simulium vittatum) bite (FB). Three additional animals were inoculated on the neck skin using FB. Clinical disease and lesion development were assessed daily, and animals were euthanatized from 12 @entity11102 ( @entity11102 ) through 120 @entity11102 . The animals inoculated in the neck failed to develop any clinical signs or gross lesions, and VSNJV was detected neither by in situ hybridization (ISH) nor by immunohistochemistry (IHC). Lesions on the CB were more severe in the animals infected by FB than by SC. In both groups, peak VSNJV replication occurred between 24 and 48 @entity11102 in keratinocytes of the CB, as evidenced by ISH and IHC. There was evidence of viral replication limited to the first 24 @entity11102 in the local draining lymph nodes, as seen through ISH. Successful @entity281 via FB required logarithmically less virus than with the SC technique, suggesting that components in black @entity238 saliva may facilitate VSNJV transmission and @entity281 in @entity291 . The lack of lesion development in the neck with the same method of inoculation used in the CB suggests that specific characteristics of the CB epithelium may facilitate @entity778 .

title: Lesion development and replication kinetics during early @entity281 in @entity291 inoculated with @entity8310 New Jersey virus via scarification and black XXXX (Simulium vittatum) bite.

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['VSNJV infection']

entities_list: @entity8310 :: ('MESH:D054243', 'Disease') :: ['Vesicular stomatitis', 'vesicular stomatitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity11102 :: ('MESH:D002372', 'Disease') :: ['hours post inoculation', 'HPI']

answer: @entity238 :: (7227,Species) :: ['fly']


abstract: Our group has been studying the progressive molecular changes in prostatic epithelium which precede the invasive phenotype. Initial studies revealed similar alterations in cytoskeletal proteins between high grade @entity5436 ( @entity5436 ) lesions and @entity189 . Specifically we observed an increased expression of certain cytokeratins and decreased expression of @entity2277 . We also noted a change in glycosylation as detected by Ulex europaeus staining. Using the latter technique we were able to microdissect and isolate nuclei from areas of low and high grade @entity4623 as well as from @entity189 for morphometric analysis. Similarities in nuclear size, chromatin heterogeneity, and nuclear DNA content between low and high grade @entity5436 and @entity189 in @entity3909 specimens were noted. In contrast, these parameters were significantly different in low grade @entity4623 obtained from benign prostatic transurethral resection (TURP) specimens. In addition, DNA histograms revealed similar proliferative indices between high grade @entity5436 and @entity189 , which differed significantly from low grade @entity5436 . Parameters thought to be relative to the invasive phenotype were also examined, such as the members of the metalloproteinase family; although normal luminal cells fail to express detectable levels of these enzymes, @entity189 and even low grade @entity4623 express both the 72 kDa and 92 kDa type IV collagenase. Taken together, these data indicate that the @entity34569 are similar in nuclear and genomic features as well as protease expression. Our current @entity1442 is that these cells are already armed with the necessary proteases to invade the basal lamina but in an inactive form. @entity5 progression requires an additional event of protease activation.

title: New relationships between XXXX and prostatic carcinoma.

entities_list: @entity34569 :: ('OMIM:603688', 'Disease') :: ['dysplastic cells of PIN lesions and carcinomas']

entities_list: @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['working hypothesis']

entities_list: @entity4623 :: ('MESH:D011469', 'Disease') :: ['PIN lesions']

entities_list: @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostatic intraepithelial neoplasia', 'PIN']

answer: @entity5436 :: (MESH:D019048,Disease) :: ['prostatic intraepithelial neoplasia']


abstract: A 60 year-old @entity1 was admitted to our hospital because of management of multiple @entity96 . According to image findings and liver biopsy, she was diagnosed as having @entity13904 of the liver accompanied by @entity3 in the spleen, lungs and bones. Based on the spread of the @entity96 and the extensive systemic @entity3 , she was considered inoperable. Instead, she received hepatic arterial infusion therapy using recombinant @entity1199 . However, she died due to @entity1578 about two months after admission. Autopsy revealed that the @entity96 was @entity5426 . It is difficult to differentiate @entity5426 from @entity13904 based on the image findings and pathological findings of percutaneous liver biopsy. Many cases are diagnosed as @entity5426 at autopsy. There is no established effective treatment for @entity99 , because the @entity5 stage at the time of diagnosis is often progressive. To date, immunotherapy with recombinant @entity1199 has been reported to be effective clinically for cutaneous @entity5426 , such as of the scalp and facial skin. To our knowledge, there have been no reported cases of @entity99 treated with recombinant @entity1199 . Our case is important should recombinant @entity1199 be considered effective for @entity99 in the future.

title: A first case of @entity99 treated with recombinant XXXX .

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors', 'liver tumor']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcoma']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity13904 :: ('MESH:D018323', 'Disease') :: ['epithelioid hemangioendothelioma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic angiosarcoma']

answer: @entity1199 :: (3558,Gene) :: ['interleukin-2']


abstract: BACKGROUND: The anterior cruciate ligament has been shown to have poor healing ability, and reconstruction is the standard treatment. HYPOTHESIS: Primary anterior cruciate ligament repair combined with bone marrow stimulation could restore stability and function in @entity2587 with acute anterior cruciate ligament incomplete tears. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Among a group of 99 @entity1 with clinically diagnosed anterior cruciate ligament acute lesions, 26 @entity2587 with arthroscopically confirmed incomplete anterior cruciate ligament proximal tears were treated with primary repair combined with bone marrow stimulation of the anterior cruciate ligament femoral attachment site. Postoperatively, all @entity1 underwent a specific rehabilitation program. All @entity1 were prospectively evaluated; outcome measures were assessed using Marx, Noyes, Tegner, Single Assessment Numeric Evaluation, Lysholm, and International Knee Documentation Committee scores. Anterior tibial translation was measured using Rolimeter instrument under anesthesia and at final follow-up. RESULTS: All @entity2587 were followed up for a mean 25.3 months (range, 17-38 months). Mean age was 26.6 years. Mean preinjury Tegner was 7.1 (SD, 1.1) and final Tegner 6.7 (SD, 1.4); mean preinjury Marx was 11.0 (SD, 3.4) and final Marx 9.6 (SD, 3.1); mean preinjury Noyes was 82.5 (SD, 5.8) and final Noyes 83.3 (SD, 7.2). These scores were not statistically different at P values of .020, .011, and .303, respectively. Final Single Assessment Numeric Evaluation rating was significantly lower than was preinjury Single Assessment Numeric Evaluation rating. This was mainly related to decreased self-confidence in high-risk sports and fear of new injury. Final Single Assessment Numeric Evaluation rating and Tegner scores were significantly higher than were their respective preoperative values. Mean Rolimeter side-to-side difference of anterior knee translation was significantly reduced from 3.5 mm (SD, 0.7) preoperatively to 1.3 mm (SD, 0.8) postoperatively. CONCLUSION: In this athletic population, anterior cruciate ligament primary repair in @entity697 combined with bone marrow stimulation effectively restored knee stability and function.

title: Primary repair combined with bone marrow stimulation in XXXX : results in a group of @entity2587 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute incomplete lesion']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute anterior cruciate ligament lesions']


abstract: BACKGROUND: Temporary atrio-ventricular conduction abnormalities following heart operations, especially the aortic valve ones, are a common complication. Irreversible complete @entity616 is a serious and rare complication. Its prevalence is estimated at 3-6% of all @entity1 that undergo aortic valve implantation. Identification of the factors which influence the occurrence of complete @entity616 with necessity of a permanent pacemaker implantation could be beneficial for risk reduction of this problem in the future. AIM: To evaluate clinical, anatomical and surgical factors that can influence complete @entity616 occurrence and cause the necessity of permanent pacemaker implantation. METHODS: In our prospective study we analysed the clinical data of consecutive 159 @entity1 operated due to isolated aortic valve dysfunction between February 2011 and March 2012. @entity1 with a pacemaker implanted before this time were excluded from the study. The main indication for operation was aortic stenosis n=114 (71.7%). @entity166 was an indication in 6 cases (3.8%). Mean age was 65.3 (  11.4). Male to female ratio was 56.6% : 43.4%. 135 @entity1 (84.9%) had sinus rhythm preoperatively. All operations were performed with median sternotomy, with cardiopulmonary bypass, in @entity2332 at 30-32  C. In 120 @entity1 (70.4%) a biological prosthesis was implanted. @entity1 who needed additional procedure such as another valve surgery, aortic surgery or coronary artery bypass grafting were excluded from the study. RESULTS: 11 @entity1 (6.9%) required permanent pacemaker implantation. The pacemaker was implanted after at least 7 days of complete @entity616 - being treated as irreversible. Single factor analysis revealed that permanent pacemaker implantation is dependent on prolonged CPB time, prolonged cross-clamp time and occurrence of electrolytic imbalance. Univariate logistic regression revealed that the necessity of permanent pacemaker implantation depends on 5 factors: prolonged CPB time, prolonged cross-clamp time, larger prosthesis implanted, @entity884 as indication for surgery and electrolytic imbalance. For both backward and forward multivariate logistic regression 2 parameters were correlated with the occurrence of complete @entity616 : prolonged cross-clamp time and electrolytic imbalance. CONCLUSIONS: Irreversible complete @entity616 is a serious complication after aortic valve surgery. Out of all analysed clinical, anatomical and surgical factors analysed, prolonged CPB time, prolonged cross-clamp time, larger prosthesis implanted, @entity884 as indication for surgery and perioperative electrolytic imbalance were found to be statistically significant permanent pacemaker implantation predictors.

title: Complete XXXX after isolated aortic valve replacement.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['atrio-ventricular block']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['Infectious endocarditis']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['endocarditis']

answer: @entity616 :: (MESH:D006327,Disease) :: ['atrio-ventricular block']


abstract: Although @entity5 microenvironments play a key role in successful @entity5 immunotherapy, effective manipulation of local immunity is difficult because of the lack of an appropriate target system. It is well known that bone marrow-derived endothelial progenitor cells (EPCs) are actively recruited during @entity5 angiogenesis. Using this feature, we attempted to establish a novel therapeutic modality that @entity5 vessels of multiple @entity3 using embryonic endothelial progenitor cells (eEPCs) transduced with an immune-activating gene. The eEPCs were retrovirally transduced with the @entity19 @entity16761 ( @entity16761 ) gene, a lymphocyte-migrating chemokine. The @entity19 @entity43 cell line OV2944-HM-1 (HM-1) was inoculated subcutaneously into B6C3F1 @entity19 , along with @entity16761 -tranduced eEPCs (eEPC- @entity16761 ), resulting in immunologic activity and @entity5 -inhibitory effects. In this model, eEPC- @entity16761 showed @entity5 repression accompanied by @entity5 -infiltrating CD8+ lymphocytes compared with the control group. In contrast, no @entity5 repression was observed when the same experiment was done in immunodeficient ( @entity915 ) @entity19 , suggesting a crucial role of T-cell function in this system. Next, we established a lung @entity3 model by injecting HM-1 cells or B16 @entity320 cells via the tail vein. Subsequent intravenous injection of eEPC- @entity16761 leads to a decrease in the number of lung @entity3 and prolonged survival. Antitumor effects were also observed in a peritoneal dissemination model using HM-1. These results suggest that systemic delivery of an immune-activating signal using EPCs can alter the @entity5 immune microenvironment and lead to a therapeutic effect, which may provide a novel strategy for targeting multiple @entity3 of various @entity5 .

title: Activated local immunity by XXXX -transduced embryonic endothelial progenitor cells suppresses @entity3 of @entity19 @entity43 .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'increased tumor', 'targets tumor', 'malignancies']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity16761 :: (24047(Tax:10090),Gene) :: ['CC chemokine ligand 19']


abstract: OBJECTIVE: To evaluate the prevalence of @entity25 in Thai @entity1 who underwent polysomnography at a single institution. METHODS: A retrospective analysis of pediatric polysomnographic studies was performed from January 2011 through December 2014. RESULTS: One hundred sixty-six studies were conducted; 142, 7, and 17 were diagnostic, split-night, and positive airway pressure (PAP) titration studies, respectively. In total, 136 diagnostic/split-night studies were performed to diagnose @entity25 with presentation of snoring (92.6  %), heavy breathing (0.7  %), witnessed @entity386 (14.7  %), excessive @entity25 (10.3  %), @entity2915 (2.2  %), @entity25 (11.0  %), @entity11795 / @entity2183 (5.9  %), @entity146 (4.4  %) and poor weight gain (0.7  %). Eleven diagnostic studies and one split-night study were performed to follow-up @entity27 ( @entity27 ) after adenoidectomy and/or tonsillectomy. One diagnostic study was conducted to follow-up @entity27 after postmandibular distraction. @entity27 was the most common diagnosis with a prevalence of 92.7  %; 40.4  % of @entity1 were diagnosed with severe @entity27 . The prevalence of sleep-related @entity3316 was 15.4  %. The second most common diagnosis was @entity10522 with a prevalence of 20.6  %. Seventeen PAP titration studies were performed. Four CPAP titration studies were conducted for @entity27 treatment. Twelve bi-level (BiPAP) titration studies were performed in eight @entity1 with @entity3316 . One BiPAP/average volume-assured pressure support titration was conducted in a @entity1 with @entity11627 ( @entity11627 ). CONCLUSIONS: The prevalence of @entity25 in Thai @entity1 who underwent polysomnography at a tertiary-care hospital is very high. The factors that contribute are the limited availability and high costs of polysomnography in Thailand. This information will encourage pediatricians to look for @entity25 in @entity1 .

title: Prevalence of @entity25 in Thai XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity11627 :: ('MESH:C536209', 'Disease') :: ['CCHS', 'congenital central hypoventilation syndrome']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['abnormal behavior']

entities_list: @entity10522 :: ('MESH:D020189', 'Disease') :: ['periodic limb movement disorder']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity']

entities_list: @entity3316 :: ('MESH:D007040', 'Disease') :: ['hypoventilation']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['restless sleep', 'sleep disorders', 'daytime sleepiness']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: Recent supermicrosurgical techniques have developed the possibility for vascular @entity254 of smaller vessels and it is now safe and sound to perform precise anastomoses between lymphatics and venules. Reported here is the 2 years experience on supermicrosurgical lymphaticovenular @entity254 and/or lymphaticovenous implantation combined with a nonoperative physical therapy for treatment of @entity1746 . Microlymphatic surgery was performed in 42 @entity1 with unilateral @entity1746 . Thirty @entity1 were @entity1 and 12 were @entity1 with a mean age of 34. Lymphaticovenular anastomoses were performed in 37 @entity1 with an average of 2.5 anastomoses per @entity1 , and lymphaticovenous implantations were made in 36 @entity1 with an average of 2.4 implantations per @entity1 . The lymphatics that were larger than 0.3 mm were anastomosed to venules with supermicrosurgical technique. Lymphaticovenous implantation technique was used for thinner lymphatics in a particular incision. Postoperatively, 18 @entity1 used continuous compressive garments, 9 @entity1 used garments but discontinued after 6 months, and no compression was used in 9 @entity1 . The results of surgery were assessed both clinically with volume measurements and by lymphoscintigraphy and were classified as good, moderate, or ineffective. The mean decrease in the volume of the @entity4 was 59.3% at an average follow-up of 11.8 months. Six outcomes were classified as ineffective, eight outcomes as moderate, and 28 outcomes as good. @entity254 and/or lymphaticovenous implantation seems to be highly beneficial, especially in the early stages of peripheral @entity4269 and may be offered as the treatment of choice in selected @entity1 .

title: XXXX and lymphaticovenous implantation for treatment of unilateral @entity1746 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis', 'Supermicrosurgical lymphaticovenular anastomosis']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

entities_list: @entity1746 :: ('MESH:D020335', 'Disease') :: ['lower extremity lymphedema']

answer: @entity254 :: (MESH:C563598,Disease) :: ['Supermicrosurgical lymphaticovenular anastomosis']


abstract: PURPOSE: To describe a series of @entity1 exhibiting annular retinal pigment epithelial (RPE) lesions in the context of @entity989 . Design; Retrospective comparative case series. METHODS: Consecutive @entity1 with @entity989 were identified from the clinical practices of 3 retina specialists. A subset of @entity1 exhibiting annular RPE lesions on fundus autofluorescence was included for chart review and examination of multimodal imaging (study group). @entity1 with alternative etiologies for @entity1713 or @entity2118 were excluded. A second consecutive cohort of @entity1 , with @entity697 , was also examined for the presence of @entity75 (comparative group). RESULTS: Sixty-seven @entity1 with @entity989 were identified. Fourteen eyes of 12 @entity1 exhibited @entity75 (study eyes). Mean visual acuity of study eyes was (20)/27 (logMAR 0.13, SD 0.11). @entity75 were composed of @entity75 arranged in an open or closed ring with intervening foci of punctate hypoautofluorescence. Optical coherence tomography showed @entity1713 at the perimeters of @entity75 with loss of ellipsoid reflectivity and preserved RPE at the lesion center. @entity75 were confined to the posterior poles and appeared to have developed at the margins of chronic @entity1713 . Forty-three eyes of 30 @entity1 with @entity697 comprised the comparative group and none of these eyes exhibited @entity75 . CONCLUSIONS: @entity75 occur in up to a fifth of @entity1 with @entity989 but carry a relatively good visual prognosis. Curvilinear RPE figures and demarcation lines are seen in various retinal conditions but the characteristics of @entity75 described here suggest that they are specific to @entity989 .

title: @entity75 and catenary forms in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute central serous chorioretinopathy']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['RPE hyperplasia', 'neurosensory detachment']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Annular lesions', 'annular lesions', 'hyperautofluorescent stellate lesions']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigment epitheliopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['chronic central serous chorioretinopathy']

answer: @entity989 :: (MESH:D012164,Disease) :: ['chronic central serous chorioretinopathy']


abstract: OBJECTIVE: To explore the relationship between the rate of decline of total fluid removal ( @entity8282 ), the sum of 24-hour urine and ultrafiltration and all-cause mortality in @entity1 undergoing @entity298 ( @entity298 ) through a prospective cohort study. METHODS: The study included 297 incident @entity1 , starting @entity298 between July 2002 and February 2007. All the @entity1 were followed up until death, transfering to hemodialysis, or kidney transplant by February 2008. Demographics, biochemical data and dialysis adequacy were collected at the baseline. The @entity8282 , urine and ultrafiltration before each clinic day were averaged every 3 months throughout the follow-up. The slope of @entity8282 ( @entity8282 ) was calculated for each @entity1 over time by a simple linear regression analysis. RESULTS: The median age was 62 years, and 42.4% of the 297 incident @entity298 @entity1 were male and 71 @entity1 (23.9%) died during the median 30-month follow-up. By multivariate Cox regression analysis, @entity8282 rather than the baseline @entity8282 was a significant risk factor of mortality after being adjusted for age, presence of @entity6 , baseline hemoglobin and serum albumin. In another multivariate model including all the above covariates, @entity8282 was superior to the baseline @entity8282 for prediction of mortality. CONCLUSION: Faster decline of total fluid removal is significantly associated with higher risk of all-cause mortality.

title: [Faster decline of total fluid removal is an independent risk factor for increased motality in XXXX on @entity298 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The incidence and prevalence of @entity6 in residents of Rochester, Minnesota, for 25 years (1945 to 1970) were determined from available medical records. The over-all incidence rate for @entity6 is 133 new cases per 100,000 population per year (age-adjusted to 1970 U. @entity1762 population). The rate increased with age for both @entity1 and @entity1 and was higher among @entity1 over 30 years of age. The average annual incidence rates per five-year period for @entity1723 were low and variable and showed little change. @entity2011 , @entity4683 , @entity10200 , lean habitus, loss of weight, and high levels of fasting @entity4854 at initial diagnosis occurred more frequently in younger than in older @entity1 . The peak incidence in 1960 through 1964 and the decrease in the following five years may be a reflection of the introduction of the AutoAnalyzer method for blood @entity413 in 1958. The average annual incidence rates for 1955 through 1959 and 1965 through 1969 were essentially the same. The over-all prevalence for @entity6 is 1.6 per cent, with a higher rate among @entity1 than among @entity1 over 40 years of age; among school @entity1 the rate is 0.1 per cent. Survivorship in the @entity6 population is lower than that in the general population. The leading cause of @entity204 was @entity301 , the @entity204 rate from it being higher than for the general population.

title: XXXX : incidence, prevalence, survivorship, and causes of @entity204 in Rochester, Minnesota, 1945-1970.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'men']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'diabetes mellitus']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity4683 :: ('MESH:D059606', 'Disease') :: ['polydipsia']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['juvenile-onset diabetes mellitus']

entities_list: @entity10200 :: ('MESH:D006029', 'Disease') :: ['glycosuria']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes mellitus']


abstract: The aim of the present study was to evaluate the effectiveness of @entity1749 combined with @entity1259 , @entity619 , and @entity2816 (BADT) for the treatment of @entity1582 ( @entity1582 ). The BADT regimen consisted of a maximum of eight 4-week cycles of: intravenous @entity1749 (1.0 mg/m(2)) and intravenous @entity1259 (12 mg/m(2)) on days 1, 4, 8, and 11; @entity619 (20 mg) on days 1, 2, 4, 5, 8, 9, 11, and 12; and oral @entity2816 (100 mg/m(2)) on days 1-28. Twelve @entity1 with @entity1582 were included in the study, of whom four had not been previously treated and eight had been previously treated with at least one cycle of a systemic combined regimen. All the @entity1 completed at least two cycles of treatment, with an average of five cycles; the complete response (CR) rate was 83.3% (10/12) and stabilization of disease was 16.7% (2/12). The average number of cycles required to achieve CR was 1.9 (range 1-6). In three @entity1 , mobilization of peripheral blood stem cells allowed a sufficient quantity of @entity2280 + cells to be harvested for future autotransplantation. The main adverse reactions included @entity1897 (4/12), @entity882 (3/12), electrocardiographic abnormalities (4/12), @entity1398 (5/12), and liver function impairment (4/12), primarily grade I-II. Infection occurred in four @entity1 with @entity1398 , including one @entity1 who developed @entity295 . The estimated 1-year overall survival rate was 91.7 +/- 8.0%, and the estimated 1-year disease-free survival was 75.0 +/- 12.5%. BADT is a highly effective combined regimen, with acceptable @entity137 , for the treatment of @entity1582 .

title: @entity1749 in combination with XXXX , @entity619 and @entity2816 is a highly effective regimen in the treatment of @entity1582 : a single-center experience.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1749 :: ('MESH:C400082', 'Chemical') :: ['bortezomib']

answer: @entity1259 :: (MESH:D015251,Chemical) :: ['epirubicin']


abstract: AIM: We studied the role of @entity36199 ( @entity36199 ) in @entity157 ( @entity157 ) progression. RESULTS: High @entity36199 expression was observed in 50.23% @entity1 . Upregulation of @entity36199 is an independent predictor for greater rates of @entity5 recurrence and shorter overall survival in @entity157 @entity1 . Knockdown of @entity36199 expression in @entity157 cells promoted apoptosis, and inhibited cell growth, colony formation, migration, as well as xenograft growth. TGF-band MAPK pathways are potentially targeted by @entity36199 . METHODS: @entity36199 mRNA expression was measured in @entity157 tissue samples and paired @entity5 samples (N=60) and results were validated in another dataset of 215 @entity157 @entity1 . Then @entity36199 expression and clinical outcomes were correlated. Malignant phenotypes were studied after @entity36199 expression was knocked down with siRNA in @entity157 cell lines. @entity36199 targeted pathways were identified by microarray analysis. CONCLUSION: @entity36199 is frequently upregulated and is an independent prognostic marker for @entity157 @entity1 and @entity36199 inhibition mitigates the malignant phenotype. Our data provide novel insight into the function of @entity36199 in @entity157 progression, and suggest that @entity36199 may be a potentially valuable biomarker for @entity157 .

title: Elevated expression of eukaryotic translation initiation factor 3H is associated with proliferation, invasion and tumorigenicity in @entity1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'non-tumor']

entities_list: @entity36199 :: ('8667', 'Gene') :: ['eukaryotic translation initiation factor 3 subunit H', 'EIF3H']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: BACKGROUND: @entity68 overload and @entity137 is the major cause of morbidity and mortality in thalassaemia @entity1 . New chelating drug protocols are necessary to treat completely transfusional @entity68 overload and eliminate associated @entity137 . Appropriate @entity23224 / @entity5532 combinations could achieve this goal. METHODS: A single-centre, single-armed, proof-of-concept study of the combination of @entity23224 (75-100 mg/kg/d) and @entity5532 (40-60 mg/kg, at least 3 d per week) was carried out in eight @entity1 with thalassaemia major (four @entity1 and four @entity1 ) for 21-68 months. The @entity1 were previously treated with @entity5532 and had variable serum ferritin [geometric (G) mean    SD = 1446    1035  g/L] and magnetic resonance imaging relaxation times T2* cardiac (Gmean    SD = 10.32    6.72 ms) and liver (G mean    SD = 3.77    4.69 ms). The use of @entity23224 (80-100 mg/kg/d) continued for 7-26 months in seven of the eight @entity1 following the combination therapy. Organ function, blood and other biochemical parameters were monitored for @entity137 . RESULTS:     The @entity23224 / @entity5532 combination caused an absolute value increase in cardiac (G mean    SD = 29.6    6.6 ms, P < 0.00076) and liver (G mean    SD = 25.9    8.07 ms, P < 0.00075) T2* and reduction in serum ferritin (G mean    SD = 114.7    139.8  g/L, P < 0.0052) to within the normal body @entity68 store range levels. In two cases, normalisation was achieved within a year. @entity23224 monotherapy was sufficient thereafter in maintaining normal range cardiac (G mean    SD = 31.4    5.25 ms, P < 0.79) and liver (G mean    SD = 26.2    12.4 ms, P < 0.58) T2* and normal serum ferritin (G mean    SD = 150.7    159.1,  g/L, P < 0.17) in five of the seven @entity1 . No serious @entity137 was observed. CONCLUSION:     Transfusional @entity68 overload in @entity1 with thalassaemia could be reduced to normal body @entity68 range levels using effective @entity23224 / @entity5532 combinations. These levels could be maintained using @entity23224 monotherapy.

title: Reduction of body XXXX stores to normal range levels in thalassaemia by using a @entity23224 / @entity5532 combination and their maintenance thereafter by @entity23224 monotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients']

entities_list: @entity5532 :: ('MESH:D003676', 'Chemical') :: ['deferoxamine']

entities_list: @entity23224 :: ('MESH:C044919', 'Chemical') :: ['Deferiprone', 'deferiprone']

answer: @entity68 :: (MESH:D007501,Chemical) :: ['iron']


abstract: OBJECTIVES: @entity5606 ( @entity5606 ) and @entity2946 ( @entity2946 ) are the most @entity1313 in early childhood. @entity5606 is frequently misdiagnosed as primitive @entity4969 . The biological features and clinical outcomes of @entity5606 and @entity2946 are extremely different. In this study, we used microarray as a platform to distinguish these two @entity5 with the definitive diagnostic marker as well as the profiling of expression genes. METHODS: In order to clarify the pathogenesis and find the biological markers for @entity5606 , we established a derivative @entity5606 primary cell culture. The differential profiling between @entity5606 and @entity2946 were analyzed by using microarray method. RESULTS: With the use of the microarray method, we demonstrated that 15 genes were significantly changed (at least 5-fold in upregulation and 1/5-fold in downregulation) between @entity5606 and @entity2946 in tissues and cell lines. The quantitative reverse transcription-polymerase chain reaction analyses further confirmed that mRNA expression levels of @entity26016 and @entity1096 were highly expressed in @entity5606 cells and tissues than those in @entity2946 . Importantly, our microarray result suggested that @entity5606 presents the @entity3308 -like pattern and expression profiling of embryonic stem cells as well as high mRNA expressions of @entity4729 , @entity2440 , @entity4731 , and @entity517 . CONCLUSIONS: Our study demonstrated the differential gene expression profiling between @entity5606 and @entity2946 . Based on the microarray findings, @entity1129 /RTs present embryonic stem-like gene recapitulation and further provide novel insights into their underlying biology.

title: Differential expression profiling between atypical teratoid/rhabdoid and XXXX in vitro and in vivo using microarray analysis.

entities_list: @entity4969 :: ('MESH:D017599', 'Disease') :: ['neuroectodermal tumor/medulloblastoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['malignant primary brain tumors']

entities_list: @entity5606 :: ('MESH:D018335', 'Disease') :: ['Atypical teratoid/rhabdoid tumor', 'AT/RT']

entities_list: @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma', 'MB']

answer: @entity5 :: (MESH:D009369,Disease) :: ['medulloblastoma tumor']


abstract: STUDY OBJECTIVES: To investigate the phenomenon of recurrent @entity4134 during the same pregnancy, describe its risk factors, and suggest possible management of this entity. DESIGN: Retrospective case-control study (Canadian Task Force classification II-3). SETTING: Gynecologic endoscopy unit in a university hospital. @entity1 AND INTERVENTIONS: Pregnant @entity1 with surgically proved @entity4134 were retrospectively identified from 1993 to 2007. Details of clinical presentation, method of conception, preoperative ultrasound findings, and operative findings were analyzed. INTERVENTION: Comparison of characteristics of @entity1 with recurrent episodes of @entity4134 during the same pregnancy vs a single episode of torsion. MEASUREMENTS AND MAIN RESULTS: Thirty-three pregnant @entity1 with 38 episodes of @entity4134 were included in the study. Seventeen pregnancies (51.5%) were spontaneously conceived. Twenty-eight @entity1 had a single episode of torsion, and 5 @entity1 (15.1%) had recurrent episodes of torsion during the same pregnancy. No significant differences were found between the 2 groups in age, method of conception, and gestational age at time of torsion. However, ultrasound studies demonstrated that @entity43 were significantly more common in @entity1 with recurrent torsion compared with @entity1 with a single episode of torsion (80% vs 25%; p =.02). The interval between the first and second episodes of torsion ranged from 1 to 4 weeks. CONCLUSION: Pregnant @entity1 are at risk for recurrent torsion, especially when the ovaries are enlarged and ultrasound studies demonstrate @entity45 . @entity45 may prevent recurrent torsion during the same pregnancy.

title: XXXX in pregnancy is associated with significant risk of recurrence.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['multicystic ovaries']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['Cyst aspiration', 'multiple cysts']

entities_list: @entity4134 :: ('MESH:D000292', 'Disease') :: ['adnexal torsion']

answer: @entity4134 :: (MESH:D000292,Disease) :: ['Maternal adnexal torsion']


abstract: UNASSIGNED: Entorhinal-hippocampal network is one of the earliest circuits which is affected by @entity195 ( @entity195 ). There are numerous data providing the evidence of synaptic deficit in the dentate gyrus (DG) of @entity195 animal model. However, there is little known about how entorhinal cortex (EC) amyloidophaty affects each excitatory and/or inhibitory transmission in the early stage of @entity195 . On the other hand, it is believed that @entity460 dyshomeostasis has a critical role in the etiology of @entity195 . Here, the effect of the EC amyloid pathogenesis on excitatory or inhibitory post synaptic currents (EPSC and IPSC, respectively) in the DG granule cells and then the possible neuroprotective action of L-type @entity460 channel blockers (CCBs), @entity3931 and @entity4768 , were examined. The amyloid beta (Ab) 1-42 was injected bilaterally into the EC of male @entity35 and one week later, synaptic currents in the DG granule cells were assessed by whole cell patch clamp. EPSCs were evoked by stimulating the perforant pathway. Voltage clamp recording showed profound decrease of evoked EPSC amplitude and paired pulse facilitation in the DG granule cells of Ab treated @entity35 . Furthermore, @entity140 / @entity3391 ratio was significantly decreased in the Ab treated animals. On the other hand, amplitude of IPSC currents was significantly increased in the DG granule cells of these animals. These modifications of synaptic currents were partially reversed by daily intracerebroventricular administration of @entity4768 or @entity3931 . In conclusion, our results suggest that Ab in the EC triggers decreased excitatory transmission in the DG with substantial decrement in @entity140 currents, leading to a prominent activity of inhibitory circuits and increased inhibition of granule cells which may contribute to the development of @entity195 -related neurological de   cits in @entity195 and treatment by CCBs could preserve normal synaptic transmission against @entity137 . This article is protected by copyright. All rights reserved.

title: XXXX channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Ab toxicity']

entities_list: @entity3931 :: ('MESH:D009553', 'Chemical') :: ['nimodipine']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity4768 :: ('MESH:D017275', 'Chemical') :: ['isradipine']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['Calcium']


abstract: @entity397 is a rare condition, and its most common cause is @entity542 . Nontraumatic disruption of the anterolateral fibrocartilaginous @entity825 is an exceptional complication following thyroidectomy with few cases reported in literature. We report a case of @entity39 arising 15 days after uneventful total thyroidectomy and resulted in @entity14303 and @entity9285 . The @entity1 felt a sudden pop in his neck following an episode of vigorous coughing and experienced rapid swelling in his neck. The presence of @entity14303 was diagnosed on chest Computed Tomography scan and bronchoscopy visualized a small perforation on the right side of the anterolateral tracheal wall. The first interesting aspect is that several factors (female gender, @entity5651 , wound @entity281 or excessive use of diathermy) reported as possible cause of @entity39 in the previous reports are unlike for the present case. The second unusual point is the spontaneous healing of the tracheal tear. Considering the no-critical ill condition of the @entity1 and the size of the tear we decide for a conservative treatment rather than surgical repair. Finally, our report underlights that the presence of @entity9285 following thyroidectomy should alert the possible existence of @entity397 . The favourable outcome of our @entity1 shows that small tracheal perforation due to @entity39 may be successfully treated with conservative treatment.

title: An unpredicted case of XXXX following thyroidectomy.

entities_list: @entity9285 :: ('MESH:D013352', 'Disease') :: ['subcutaneous emphysema']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['anterior tracheal necrosis', 'tracheal necrosis', 'upper tracheal necrosis']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head and neck injury']

entities_list: @entity14303 :: ('MESH:D008478', 'Disease') :: ['pneumomediastinum']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['tracheal rupture', 'Tracheal rupture']

entities_list: @entity5651 :: ('MESH:D006042', 'Disease') :: ['thyrotoxic goiter']

answer: @entity39 :: (MESH:D009336,Disease) :: ['tracheal necrosis']


abstract: BACKGROUND: Although a common symptom in @entity1 with severe @entity472 ( @entity472 ) without obstructive @entity453 ( @entity453 ), little is known about the pathogenesis of exertional @entity951 . OBJECTIVES: This study sought to prove that @entity409 is responsible for @entity662 in @entity1 with severe @entity472 and normal epicardial coronary arteries using @entity859 -stress cardiac magnetic resonance (CMR) imaging. METHODS: Between June 2012 and April 2015, 117 @entity1 with severe @entity472 without obstructive @entity453 and 20 normal controls were enrolled prospectively. After exclusions, study @entity1 were divided into 2 groups according to presence of exertional @entity662 : an @entity951 group (n  = 43) and an asymptomatic group (n  = 41), and the semiquantitative myocardial perfusion reserve index (MPRI) was calculated. RESULTS: MPRI values were significantly lower in severe @entity472 @entity1 than in normal controls (0.90    0.31 vs. 1.25    0.21; p  < 0.001), and were much lower in the @entity951 group than the asymptomatic group (0.74    0.25 vs. 1.08    0.28; p  <  0.001). In logistic regression analysis, the only independent predictor for @entity951 was MPRI (odds ratio: 0.003; p  <  0.001). Univariate associations with MPRI were identified for diastolic blood pressure, E/e' ratio, left ventricular volume and ejection fraction, cardiac index, presence of late @entity2287 enhancement, and left ventricular mass index (LVMI). In  multivariate analysis, LVMI was the strongest contributing factor to MPRI (standardization coefficient: -0.428; p  <  0.001). CONCLUSIONS: Our results suggest that, in @entity1 with severe @entity472 without obstructive @entity453 , @entity951 is related to impaired coronary microvascular function along with @entity1184 detectable by semiquantitative MPRI using @entity859 -stress CMR. CLINICAL TRIAL REGISTRATION: NCT02575768.

title: Coronary Microvascular Dysfunction as  a Mechanism of Angina in Severe @entity472 : Prospective XXXX -Stress CMR Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['LV hypertrophy']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['microvascular dysfunction']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

answer: @entity859 :: (MESH:D000241,Chemical) :: ['Adenosine']


abstract: Spindle cell @entity20027 with @entity4648 and thick collagen bundles has not yet been described, and there are no published reports on its cytological appearance in fine-needle aspiration (FNA). A 49-year-old @entity1 presented with a painless mass in the right submandibular area that had been gradually enlarging for a period of 5 years. The cytologic smears showed fascicles of cohesive spindle cells as well as individual bland cells with bipolar naked nuclei in a fibrillary background. Brightly eosinophilic bundles were intermingled with spindle cells and fat-like vacuoles. The FNA results were suggestive of @entity5 . @entity1 underwent submandibular gland resection. Grossly, the cut surface showed a well-encapsulated, yellowish-white, soft, elastic mass, measuring 2.8 * 1.9 * 1.5 cm. The @entity5 consisted of uniform bland spindle cells arranged in short fascicles admixed with adipocyte-like cells and transversing thick collagen bundles, which demonstrated immunoreactivity for myoepithelial markers and ultrastructural features characteristic of myoepithelial cells, suggesting the presence of @entity4648 . The FNA cytology of spindle cell @entity20027 with extensive lipometaplasia mimicked that of @entity5 or lipomatous @entity361 . This case represents the first description of submandibular gland @entity20027 with lipometaplasia, which is characterized by the coexistence of spindle cells, collagen bundles, and fat-like vacuoles in a fibrillary background. Diagn. Cytopathol. 2016;44:764-769.    2016 Wiley Periodicals, Inc.

title: A case report of spindle cell @entity20027 with XXXX and thick collagen bundles in the submandibular gland.

entities_list: @entity20027 :: ('MESH:D009208', 'Disease') :: ['myoepithelioma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neurogenic tumor']

entities_list: @entity4648 :: ('MESH:D008679', 'Disease') :: ['extensive lipomatous metaplasia', 'lipomatous metaplasia']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumor']

answer: @entity4648 :: (MESH:D008679,Disease) :: ['extensive lipomatous metaplasia']


abstract: The possible aetiological factors in non-gonococcal and non-specific @entity6369 are reviewed. The response of NSU to various courses of different @entity803 drugs is assessed. Prolonged courses of treatment did not give better results than shorter courses. When reviewing the infective aetiology of @entity2954 , it was noted that more than one organism (or potential pathogen) would be present in many cases. It is therefore surmised that there may be at times a mixed aetiology and at other times a truly non-specific aetiology. Isolations by different workers have indicated that the following organisms might be expected: Chlamydia 40 per cent.; @entity5940 - @entity5940 20 per cent., T-strain over 60 per cent.; Trichomonas 15 per cent.; Candida possibly over 5 per cent. Truly non-specific @entity6369 may account for 25 to 30 per cent. of cases.

title: XXXX and the tetracyclines.

entities_list: @entity6369 :: ('MESH:D014526', 'Disease') :: ['urethritis']

entities_list: @entity2954 :: ('MESH:D006069', 'Disease') :: ['non-gonococcal urethritis']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity5940 :: ('2098', 'Species') :: ['M. hominis', 'Mycoplasma']

answer: @entity6369 :: (MESH:D014526,Disease) :: ['Non-specific urethritis']


abstract: In 490 working @entity1 , aged 40-59 years the sequelae of borderline @entity101 (BH) were evaluated. The @entity1 with BH (n = 253) were matched with normal controls (n = 237). At 13 years the cardiovascular state, ability to work and mortality were assessed. A significantly more frequent incidence of @entity4346 and overload was found when @entity101 developed. In the group of initial BH less @entity1 continued work (36%) than in the control group (48.1%, p less than 0.01), despite the same age. A relation between the ability to work and blood pressure becomes more prominent while taking into account final diagnosis; i.e. 65.7% of actual normotensives, 56.4% of the @entity1 with BH and 47.5% with @entity101 continue their work. The mortality rate was higher (15.4%) in the group with BH than in the controls (8.4%, p less than 0.01). The highest death rate was found when BH was combined with other coronary risk factors. The results confirm the presence of both indirect (through the development of @entity101 ) and harmful effects of BH. They also show the need of devoting special attention to @entity1 with BH and concommitant coronary risk factors.

title: [Selected problems of diagnosis, natural course and prognostic significance of borderline XXXX . II. Sequelae of borderline @entity101 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'arterial hypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['arterial hypertension']


abstract: Among its many functions, @entity4090 (PRL) participates in immune responses and promotes the activation, differentiation and proliferation of T cells. However, the mechanisms by which PRL regulates regulatory T (T(reg)) cells are still unknown. Our goal was to determine whether PRL plays a role in T(reg) function. We measured the expression of PRL and its receptor in T(reg) and effector T (T(eff)) cells from 15 healthy individuals. We also evaluated the functional activity of T(reg) cells by examining proliferation and cytokine secretion in cells activated with anti-CD3/ @entity1361 in the presence or absence of PRL. We report that T(reg) cells constitutively expressed @entity12595 , whereas T(eff) cells required stimulation with anti-CD3/ @entity1361 to induce @entity12595 expression. Expression of PRL was constitutive in both populations. We found that the addition of PRL inhibited the suppressor effect (proliferation) mediated by T(reg) cells in vitro, reducing suppression from 37.4 to 13% when PRL was added to co-cultures of T(reg) and T(eff) cells (P<0.05). Cultures treated with PRL favoured a @entity1198 cytokine profile, with increased production of TNF and IFNy. We report for the first time that @entity12595 expression was constitutive in T(reg) cells but not in T(eff) cells, which require stimulation to induce @entity12595 expression. PRL inhibited the suppressive function of T(reg) cells, apparently through the induced secretion of @entity1198 cytokines.

title: XXXX down-regulates CD4+CD25hiCD127low/- regulatory T cell function in humans.

answer: @entity4090 :: (5617,Gene) :: ['Prolactin']


abstract: BACKGROUND: Increasing survivorship warrants evidence-based intervention to help @entity1 manage living effectively with @entity0 . @entity0 survivors may have many medical and psychosocial issues in the post- treatment period. Qualitative research was carried out to assess survivors' overall experience and if intervention helps in survivorship care. This paper reports exploration of benefit-findings from participation in an earlier 4-week self management intervention. METHODS: We used a grounded theory approach to analyze three focus groups conducted between May and August 2010 in Kuala Lumpur. We used random sampling to recruit the informants (n=21), all of whom had earlier participated in the 4 week self-management program held two years previously. FINDINGS: The @entity1 reported positive experience and growth with the self management program. Self-efficacy appears as an important underlying theme for successful experiences. The lack of proactive plans to provide bereavement support to surviving @entity1 was a key negative experience. CONCLUSION: The intervention successfully brought @entity1 together to work in close partnership with health professionals on ways to self manage the medical, emotional and role task as they live indefinitely with @entity0 , a new @entity102 . The beneficial effect from the 4 week intervention was expressed by @entity1 even at 2 years after the program. Having successfully developed a tightly knitted group, a major oversight was the lack of professional support on bereavement for grieving members when close friends passed away.

title: Qualitative experiences of XXXX survivors on a self-management intervention: 2-year post-intervention.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illness']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: We report our experience with 90 neurologically impaired @entity1 treated with gastrostomy and Nissen fundoplication. @entity3147 was the main problem, followed by @entity1173 , recurrent @entity55 , and @entity391 . The symptomatology was caused by swallowing incoordination and @entity354 . The diagnosis of @entity354 was confirmed by upper gastrointestinal series and pH probe. Nissen fundoplication was performed following a standard technique with preservation of the vagus nerves and its branches, repair of the diaphragmatic crura, reconstruction of the angle of His, and a 360 degree wrap. A gastrostomy and pyloroplasty or pyloric dilatation were part of the operative procedure. There were no deaths and few complications related to the surgical procedure. Marked nutritional improvement was seen in most cases with an average weight gain of 3.2 kg/ @entity1 3 months following surgery. There was also improvement in milestones and @entity410 control. The majority of parents were very satisfied and would recommend the procedure to other parents with similar problems.

title: Gastrostomy and Nissen fundoplication in neurologically impaired XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['Malnutrition']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity1 :: (9606,Species) :: ['children']