abstract: BACKGROUND: Multiple complex pathways are operable in the evolution of cutaneous T cell lymphomas (CTCLs). These pathways involve interaction between neoplastic T cells and cells of the immune system (especially dendritic cells and the non-malignant T cells). @entity35424 is a proinflammatory antimicrobial peptide which has an immune alarmin function, activating dendritic cells, as well as an active role in @entity5 immunology and prognosis. @entity403 + regulatory T cells Tregs are an important player in the immune system. Much controversy is found in the literature about the role of Tregs in CTCL. AIM: The present study aimed to investigate the expression of @entity35424 and @entity403 in @entity4888 ( @entity4888 ), its precursor lesion @entity20956 and its leukemic form Sezary syndrome ( @entity14041 ). MATERIALS AND METHODS: Immunohistochemical expression of @entity35424 and @entity403 were assessed in lesional skin biopsies taken from 58 @entity1 (4 @entity20956 , 48 @entity4888 and 6 @entity14041 ). RESULTS: @entity35424 positivity was cytoplasmic and higher in @entity4888 than in @entity20956 en plaque and higher in the more advanced stages of @entity4888 (p<0.001). All groups showed significant differences between each other except between @entity5 stage and @entity14041 . @entity403 positivity was nuclear and higher in early stage @entity4888 (plaque and patch stages) than in @entity5 stages and @entity14041 (p<0.001). However the @entity403 count was lower in @entity20956 en plaque than in other stages of @entity4888 . All the groups showed significant differences between each other except between @entity20956 and @entity14041 and between patch and plaque stages of @entity4888 . CONCLUSIONS: The present study supports a role for @entity35424 in @entity4888 progression and proposes a novel hypothesis about the effect of @entity403 +veTregs in the suppression of the activity of the neoplastic cells in @entity4888 .

title: Expression of @entity35424 and XXXX in Cutaneous T Cell Lymphoma and S  zary Syndrome.

entities_list: @entity35424 :: ('10578', 'Gene') :: ['granulysin', 'Granulysin']

entities_list: @entity4888 :: ('MESH:D009182', 'Disease') :: ['mycosis fungoides', 'MF']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'MF tumor']

entities_list: @entity20956 :: ('MESH:D010267', 'Disease') :: ['large plaque parapsoriasis', 'parapsoriasis']

answer: @entity403 :: (50943,Gene) :: ['FOXP3']


abstract: Psychoeducation (PE) for @entity161 and other @entity914 is widely adopted but insufficiently evaluated. So far, meta-analytic data has demonstrated efficacy for PE when interventions include family members. Whether PE directed solely at @entity1 is also effective remains unclear. The current meta-analysis evaluates short- and long-term efficacy of PE with and without inclusion of families with regard to relapse, symptom-reduction, knowledge, medication adherence, and functioning. Randomized controlled trials comparing PE to standard care or non-specific interventions were included. A literature search in the Cochrane Library, PsycINFO and Medline retrieved 199 studies for closer examination, of which 18 studies, reporting on 19 comparisons, met the inclusion criteria. These studies were coded with regard to methodology, @entity1 , interventions and validity. Effect sizes were integrated using the fixed effects model for homogeneous effects and the random effects model for heterogeneous effects. Independent of treatment modality, PE produced a medium effect at post-treatment for relapse and a small effect size for knowledge. PE had no effect on symptoms, functioning and medication adherence. Effect sizes for relapse and rehospitalization remained significant for 12 months after treatment but failed significance for longer follow-up periods. Interventions that included families were more effective in reducing symptoms by the end of treatment and preventing relapse at 7-12 month follow-up. Effects achieved for PE directed at @entity1 alone were not significant. It is concluded that the additional effort of integrating families in PE is worthwhile, while @entity1 -focused interventions alone need further improvement and research.

title: Effectiveness of psychoeducation for relapse, symptoms, knowledge, adherence and functioning in XXXX : a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorders']

answer: @entity914 :: (MESH:D011618,Disease) :: ['psychotic disorders']


abstract: OBJECTIVE: The purpose of this study was to investigate the effects of single/double or repeated intake of a normal amount of tea @entity12919 on plasma @entity12919 concentrations and antioxidant activity in young @entity1 . DESIGN: First, after an overnight fast, five healthy subjects were given water or single/double dose(s) of tea @entity3978 extract (164 mg tea @entity23382 containing 61% @entity3089 in 190 ml water). Blood samples were taken before and 30, 60 and 180 min after the ingestion. Second, 16 healthy subjects ingested the tea @entity3978 extract three times a day at mealtimes for 7 days followed by withdrawal of tea @entity3978 extract for 7 days. Blood samples were taken before and after ingestion, and 7 days after the withdrawal of tea @entity12919 . Subjects were prohibited from drinking any beverages containing @entity6398 or antioxidant supplements during the study period. @entity12919 and other antioxidant concentrations in the plasma were measured, and changes in antioxidant activity were evaluated by ferric reducing ability of plasma assay. RESULTS: Single/double ingestion of tea @entity3978 extract did not cause an increase in the antioxidant activity. There was no also change in antioxidant activity after the ingestion of tea @entity3978 extract for 7 days. Plasma-free @entity3089 concentration remained at the pre-study level; however, the plasma @entity19213 value decreased significantly at 7 days after the withdrawal of tea @entity3978 extract. Decreases in endogenous antioxidants in the plasma, including @entity620 and @entity648 , were also observed 7 days after withdrawal of tea @entity3978 . CONCLUSIONS: The results suggest that continuous daily intake of tea @entity23382 affects the concentrations of endogenous antioxidants in the plasma and has the potential to maintain total antioxidant activity.

title: The relation between single/double or repeated tea XXXX ingestions and plasma antioxidant activity in @entity1 .

entities_list: @entity3978 :: ('CHEBI:26195', 'Chemical') :: ['polyphenol']

entities_list: @entity23382 :: ('CHEBI:23053', 'Chemical') :: ['catechins']

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity12919 :: ('MESH:D002392', 'Chemical') :: ['catechin', 'Catechin']

entities_list: @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin gallate']

entities_list: @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols']

answer: @entity12919 :: (MESH:D002392,Chemical) :: ['catechin']


abstract: INTRODUCTION: The aim of this study was to describe the @entity3503 beam coagulation (ABC) technique in the palliative treatment of @entity1 with nonresectable @entity189 of the @entity418 and oesophagus and this treatments needs, complications and tolerance. METHODOLOGY: A retrospective evaluation of 31 @entity1 referred for palliation by ABC over a period of nearly four years (1.1.98-31.8.01). RESULTS: Twenty-two @entity1 and nine @entity1 , median age 72 years (range 49-91 years), underwent a total of 163 treatments and a median of five treatments per @entity1 (range 1-18). Recanalisation enabling passage of the scope was achieved in 89% of treatments, and most of these @entity1 had @entity1282 grade = 2. The median range between reinterventions was 25 days (range 1-175 days). Perforation was seen in three @entity1 and in 1.8% of treatments; procedure related mortality was 1.2%. The median hospital stay for every treatment was two days (range 1-27 days) and the median inpatient stay as a proportion of survival time was 8%. The median survival was 190 days (range 7-612 days) with the 1-year survival 19%. DISCUSSION: ABC is a well-tolerated, safe and effective treatment in @entity1 with non-resectable @entity5 and offers an acceptable complication rate and number of reinterventions compared with laser and stent placement. The technique is easy and cheap, and requires no further restrictions than conventional monopolar electro coagulation does. Prospective randomised trials comparing the efficacy of the different palliative treatments for @entity1 with @entity5 are needed.

title: Palliation of non-resectable XXXX of the @entity418 and oesophagus by @entity3503 beam coagulation.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer of the oesophagus or cardia', 'oesophagogastric cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinoma']


abstract: BACKGROUND: Blunt traumatic @entity764 (BTAI) can be a highly lethal injury but in the last decade major advances have been made in diagnostic accuracy, injury grading, and therapy. Traditionally, emphasis has been on studying survival postinjury with a paucity of studies examining the discharge characteristics of @entity1 that survive a BTAI. The purpose of this study is to define the epidemiology and predictors of disposition in @entity1 with BTAI in a provincial database. METHODS: Using the Ontario @entity130 Registry, all @entity1 were identified who were hospitalized with a BTAI between 1999 and 2009. Trends in therapy and discharge disposition were determined. RESULTS: We identified 264 cases of BTAI. Of these, 157 were discharged from hospital with 36% (n  =  56) going directly home and 64% (n  =  101) going to continuing care facilities. There was no difference in disposition in those with BTAI treated operatively or nonoperatively (P  =  0.48). In those that had repair of BTAI, there was no difference in discharge home between open and endovascular repair (P  =  1.00). Univariate analyses identified younger age, male sex, @entity130 severity score (ISS), and lower Charlson comorbidity indices as being predictors of discharge home. On adjusted multivariate regression analysis, lower ISS (odds ratio, 0.91; 95% confidence interval, 0.87-0.95; P  <  0.001) was the only independent predictors of discharge home. CONCLUSIONS: Our findings suggest that the only independent predictor for discharge home for @entity1 who survive is the overall severity of all their injuries irrespective of their condition on admission or management of their BTAI.

title: Predictors of Discharge Home after Blunt Traumatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['thoracic aortic injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['lower injury', 'Trauma']

answer: @entity764 :: (MESH:D013898,Disease) :: ['Thoracic Aortic Injury']


abstract: BACKGROUND: Lower urinary tract symptoms associated with @entity1069 ( @entity1069 ) occur in up to 70% of @entity1 over the age of 60 years. To relieve these bothersome symptoms, treatment options include alpha-antagonists, also know as alpha-blockers. OBJECTIVES: We conducted a systematic review to evaluate the effectiveness and adverse effects of the alpha-blocker, @entity7477 , for treatment of urinary symptoms associated with @entity1069 . SEARCH STRATEGY: Trials were searched in computerized general and specialized databases (MEDLINE, Cochrane Library), by checking bibliographies, and by contacting manufacturers and researchers. SELECTION CRITERIA: Studies were included if they (1) were randomized trials of at least 1 month duration, and (2) included @entity1 with symptomatic @entity1069 and compared @entity7477 with placebo or active controls. DATA COLLECTION AND ANALYSIS: Study, @entity1 characteristics and outcomes data were extracted in duplicate onto standardized forms utilizing a prospectively developed protocol. The main outcome measure for comparing the effectiveness of @entity7477 with placebo or other @entity1069 medications was change in urological symptoms as measured by validated symptom scores. Secondary outcomes included urodynamic measures. The main outcome measure for adverse effects was the number of @entity1 reporting side effects. We also evaluated the number of @entity1 withdrawing from treatment and the number withdrawing due to adverse effects. MAIN RESULTS: 17 studies involving 5,151 subjects met inclusion criteria (placebo-controlled (10); alpha-blockers (7); @entity585 alone or in combination with @entity7477 as well as placebo (1); microwave therapy (TUMT) (1). Study duration ranged from 4-52 weeks. Mean age was 65 years and 82% of @entity1 were white. Baseline urologic symptom scale scores and flow rates demonstrated that @entity1 had moderate @entity1069 . Efficacy outcomes were rarely reported in a fashion that allowed for data pooling but indicated that @entity7477 improved symptom scores and flow rates more than placebo or @entity585 and similarly to other alpha antagonists. The pooled mean percentage improvements for the Boyarsky symptom score was 37% for @entity7477 versus 15% for placebo (n=4 studies). The mean percentage improvement for the American Urological Association symptom score (AUA) was 38% compared to 17% and 20% for placebo and @entity585 , respectively (n = 2 studies). The pooled mean improvement in the International Prostate Symptom Score (IPSS) (40%) was similar to @entity9940 (43%). Peak urine flow rates improved greater with @entity7477 (22%), than placebo (11%) and @entity585 (15%) but did not differ significantly from the other alpha-blockers. The percentage of @entity1 discontinuing @entity7477 was comparable to @entity1 receiving placebo and @entity585 but was greater then with other alpha-antagonists. Adverse effects were greater than placebo and included @entity1296 , @entity1395 , @entity10 and @entity551 . REVIEWER'S CONCLUSIONS: The available evidence suggests that @entity7477 improves urinary symptoms and flow measures associated with @entity1069 . Effectiveness is superior to placebo or @entity585 , similar to other alpha-blockers but less than TUMT. Adverse effects were generally mild but more frequent than other alpha-blockers and associated with between a two-four fold increase in treatment discontinuation.

title: XXXX for benign prostatic hyperplasia.

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['BPO', 'benign prostatic obstruction']

entities_list: @entity585 :: ('MESH:D018120', 'Chemical') :: ['finasteride']

entities_list: @entity7477 :: ('MESH:C041226', 'Chemical') :: ['terazosin']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['postural hypotension']

entities_list: @entity9940 :: ('MESH:C088482', 'Chemical') :: ['tamsulosin']

answer: @entity7477 :: (MESH:C041226,Chemical) :: ['Terazosin']


abstract: Reviews of stored electrograms from ICDs revealed a 5-30% incidence of short-long-short intervals preceding the onset of recurrent @entity1165 . Rate stabilization by dedicated antibradycardia pacing algorithms has, therefore, been suggested to prevent onset of pause dependent @entity591 . However, the clinical efficacy of this approach has not been studied systematically. In a prospective multicenter crossover study, @entity1 were randomized to activation or deactivation of an implemented ventricular rate stabilization algorithm (VRS) after first implant of a dual chamber @entity1479 . After 3 months, all @entity1 were crossed over to the alternate programming. The rate of appropriate spontaneous VA episodes was compared between VRS On and VRS Off. Stored electrograms were reviewed for evaluation of the mode of onset of @entity591 . Overall efficacy analysis was based on 309 @entity1 enrolled in the study. Forty percent (124/309) of the @entity1 experienced 4,973 VA episodes. Based on an intention-to-treat analysis, VRS Off and On @entity943 incidence was 10.2 and 6.6 normalized to 3 months, respectively (risk reduction 35%; P = 0.18) On an on-treatment basis, a reduction from 9.0 episodes to 8.1 episodes (10% risk reduction, P = 0.24) was seen. In an extended Cox model adjusting for confounding variables, the relative risk for recurrent episodes was 0.92 during VRS On compared to Off (95% CI: 0.58-1.48; P = 0.74). During VRS Off, pause dependent onset was documented in only 36 (8%) of 427 visually analyzed episodes. There was no significant reduction in the incidence of recurrent @entity1165 with VRS On compared to the Off programming in this prospective study.

title: Ventricular rate stabilization for the prevention of pause dependent XXXX : results from a prospective study in 309 @entity1479 recipients.

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachyarrhythmias']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachyarrhythmias']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity1165 :: (MESH:D017180,Disease) :: ['ventricular tachyarrhythmias']


abstract: Roe deer (Capreolus capreolus) is one of the most common game mammals in Europe, where hundreds of thousands @entity1 are exposed to this animal. Despite this fact, we are aware of only two cases of @entity566 to roe deer published until recently, one case of @entity56 and @entity565 and the second of contact @entity110 . We describe another case with co-existing @entity56 contact @entity110 and @entity2490 in a 55-year old male professional hunter. The symptoms were provoked only by exposure to roe deer, and there were no other past or present @entity56 . Specific IgE was found to following animal allergens: @entity291 dander (CAP class 5), @entity1237 epithelium and @entity1641 dander (each CAP class 4), @entity235 epithelium, @entity235 dander and @entity1707 epithelium (each CAP class 2). Skin prick tests have shown positive reaction only to @entity291 epithelium (+). Because of lack of deer dander allergen for specific IgE and skin tests, we have confirmed the causal relationship between exposure to roe deer and @entity566 using the rub test with roe deer's fur. There was a clearly positive urticarial reaction on the @entity1 's skin accompanied by nasal itch, sneezing and @entity5254 . No reaction was seen in a control @entity1 . We surmise that the positive tests with @entity291 epithelium seen in this @entity1 may result from a cross-reactivity to deer allergens. We conclude that although occupational @entity566 to roe deer seem to be rare, such possibility should be always considered among @entity1 having contact with these animals.

title: XXXX @entity110 and @entity2490 to roe deer (Capreolus capreolus) in a hunter.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'person', 'people']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies']

entities_list: @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic rhinoconjunctivitis', 'allergic diseases', 'allergic']

entities_list: @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']

answer: @entity56 :: (MESH:D004342,Disease) :: ['Allergic contact']


abstract: OBJECTIVE: To evaluate the use of decreasing differential function (DF) as an indication for surgery in @entity1 with congenital @entity3041 followed according to a flow chart with repeated renography and ultrasonography. @entity1 AND METHODS: The hospital records of consecutive @entity1 (0-12 years old) who underwent an Anderson-Hynes pyeloplasty between 1993 and 2000 were reviewed. Follow-up was recommended according to a flow chart, with isotope renography and ultrasonography at 1, 3 and 6 months, and at 1 (2), 3 and 5 years of age. The diagnosis and follow-up were often at the referring hospital. The criteria for surgery included a decrease in renographic DF of > 10% of DF, and a DF of < 42%, breakthrough @entity2885 despite antibiotic prophylaxis, @entity158 or an anterior-posterior pelvic diameter of > 50 mm. RESULTS: Fifty-two @entity1 with unilateral @entity3041 were included; eight had surgery because of decreasing DF of the hydronephrotic kidney. Seven @entity1 had a prenatal diagnosis. Only one of these eight @entity1 was managed according to the recommended procedures for follow-up. In two and possibly three @entity1 there was significant irreversible @entity8 since the initial renography before surgery. In one @entity1 the initial renography was at 15 months and the DF was < 10%. There was a functional improvement after surgery in three @entity1 . CONCLUSION: Few @entity1 undergo surgery for decreasing DF of the hydronephrotic kidney in this study. Failure to adhere to the follow-up schedule was common; this may jeopardize kidney function when using decreasing DF as a criterion for surgery. Therefore, not complying (by medical staff or the @entity1 ) with the follow-up should be considered when using expectant management for asymptomatic @entity3041 . The serious consequences for renal function of not complying with follow-up can be avoided by surgery if the @entity1 @entity177 , by close cooperation with medical staff at referring hospitals, and by close follow-up at an early age with renography and ultrasonography.

title: Renal function may not be restored when using decreasing differential function as the criterion for surgery in unilateral XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient', 'PATIENTS', 'child']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney damage']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['risks renal functional deterioration']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

answer: @entity3041 :: (MESH:D006869,Disease) :: ['hydronephrosis']


abstract: Background Although @entity32117 is characterized by idiopathic TIN with bilateral anterior @entity1596 , few reports have provided a comprehensive summary of the features of this disorder. Previous reports have suggested that many Japanese @entity1 had HLA-A2 and -A24 (7), but there is no evidence. Case Report A 44-year-old female was referred to our hospital due to @entity8 in March 2012. After admission, her symptoms improved spontaneously without medication within 2 weeks. In the outpatient clinic, she was diagnosed with idiopathic bilateral anterior @entity1596 in May, and her @entity8 relapsed in November. A renal biopsy showed diffuse TIN. We made a diagnosis of @entity32117 because we could not explain the origin, and treated her with a systemic corticosteroid. Her renal function and ocular symptoms have been improving. The @entity1 had @entity5958 , -C*07: 02 and - @entity3098 *05: 01: 01. We collected 102 Japanese cases in PubMed, Ovid MEDLINE, and the Japanese Medical Abstracts Society and compared our case with the previous cases. Conclusions This disorder affects primarily young females (median age, 14 years), and the most common symptom is fever (44/102 cases). We conducted a statistical analysis using contingency table and Pearson's chi-square test, for HLA-A2 and A24, and calculated the odds ratio (OR). There are no significant differences (A2 was present in 7/22 cases and in 19/50 controls, p value (P) 0.61, OR 0.76 (95% confidence interval (CI)) 0.27-2.2; A24 was present in 10/22 cases and in 33/50 controls, P 0.10, OR 0.43, CI 0.16-1.2).

title: A Report of an Adult Case of XXXX ( @entity32117 ) Syndrome, with a Review of 102 Japanese Cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal dysfunction']

entities_list: @entity32117 :: ('MESH:C536922', 'Disease') :: ['TINU syndrome']

answer: @entity32117 :: (MESH:C536922,Disease) :: ['Tubulointerstitial Nephritis and Uveitis']


abstract: To evaluate the safety and efficacy of @entity7046 in adults <65, 65 to 79, or > or =80 years old with community-acquired @entity55 , adult male and female outpatients from general community-based practices were enrolled in an open-label, multicenter, noncomparative study. @entity7046 400 mg once daily was administered for seven to 14 days. Medical history, physical examination, signs and symptoms of @entity281 , Gram stain and culture if specimen available, clinical response, and safety were determined. Of 1655 treated @entity1 , 1103 were at least 65 years old, 405 were 65 to 79, and 147 were at least 80. @entity1 > or =80 years old presented with chills, @entity662 , @entity221 , or @entity10 less often than younger @entity1 . Cure rates were 95.5% for @entity1 <65 years old, 96.2% for those 65 to 79, and 90.2% for those at least 80 years old. Neither the frequency nor susceptibility of isolated pathogens appeared to differ with age. Between 93.7% and 100% of subsets of the two younger groups with verified @entity328 or @entity6932 were cured. All oldest-group @entity1 in the subset with verified @entity2260 and 71.4% (7) of @entity1 with @entity327 were cured. Each age group, including current or past smokers and @entity1 receiving medications for concomitant conditions, tolerated treatment well. @entity7046 is safe and efficacious in adults of any age with community-acquired @entity55 , including the elderly up to 100 years old and @entity1 with @entity2260 including @entity114 -resistant strains.

title: Efficacy and safety of @entity7046 in elderly outpatients with community-acquired XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity7046 :: ('MESH:C078049', 'Chemical') :: ['Gatifloxacin', 'gatifloxacin']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity327 :: ('727', 'Species') :: ['H. influenzae']

entities_list: @entity6932 :: ('MESH:D008583', 'Disease') :: ['Hemophilus influenzae']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity55 :: (MESH:D011014,Disease) :: ['pneumonia']


abstract: STUDY DESIGN: Seventy thoracolumbar spines from cadavers of individuals killed in motor vehicle accidents were examined pathologically and radiologically, particularly for the occurrence of @entity697 . OBJECTIVES: To document whether @entity22336 occur acutely as a result of @entity130 . SUMMARY OF BACKGROUND DATA: Theories proposed to explain the pathogenesis of @entity22336 include @entity179 . Few studies show a direct causal relation between a traumatic episode and acute Schmorl's node formation. METHODS: Thoracolumbar spines were removed at autopsy, underwent radiography in the anteroposterior and lateral planes, fixed, sagittally cut, and underwent radiography a second time. Pathologic and radiographic examinations were performed. RESULTS: Nine @entity697 were detected, most in association with other acute injuries to the spine. Most @entity697 were present in spines from individuals aged 11-30 years, with a male to female ratio of 9:1, and were localized to the T8-L1 region. Spines from motorcyclists showed the highest percentage of @entity697 . No @entity697 were detected radiologically. CONCLUSION: @entity22336 do occur acutely as the result of a single traumatic episode, and are almost always associated with other acute @entity3510 . The frequency and occurrence of @entity697 in motorcyclists suggest that axial loading is an important mechanism. Their predominance in the T8-L1 region suggests that this region is particularly susceptible to stress.

title: The pathogenesis of @entity22336 in relation to acute XXXX . An autopsy study.

entities_list: @entity3510 :: ('MESH:D013124', 'Disease') :: ['spinal injury']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ["acute Schmorl's nodes"]

entities_list: @entity22336 :: ('MESH:D011213', 'Disease') :: ["Schmorl's nodes"]

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['developmental, degenerative, traumatic, and disease influences']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: There is increasing evidence that proteins function in the cell as integrated stable or temporally formed protein complexes, interactomes. Previously, using model systems we demonstrated applicability of direct molecular @entity9963 on paramagnetic particles for protein interactomics (Ershov et  al. Proteomics, 2012, 12, 3295). In the present study, we have used a combination of affinity-based molecular @entity9963 and subsequent @entity15 for investigation of @entity1 liver proteins involved in interactions with immobilized microsomal cytochrome b5 ( @entity28437 ), and also transthyretin and BSA as alternative affinity ligands (baits). The LC- @entity15 / @entity15 identification of prey proteins fished on these baits revealed three sets of proteins: 98, 120, and 220, respectively. Comparison analysis of these sets revealed only three proteins common for all the baits. In the case of paired analysis, the number of common proteins varied from 2 to 9. The binding capacity of some identified proteins has been validated by a @entity29552 -based biosensor. All the investigated proteins effectively interacted with the immobilized @entity28437 (Kd values ranged from 0.07 to 1.1  M). Results of this study suggest that direct molecular @entity9963 is applicable for analysis of protein-protein interactions (PPI) under normal and pathological conditions, in which altered PPIs are especially important.

title: Protein interactomics based on direct molecular XXXX on paramagnetic particles: Practical realization and further @entity29552 validation.

answer: @entity9963 :: (MESH:D005393,Disease) :: ['fishing']


abstract: @entity5 is characterized by mutations, genome rearrangements, epigenetic changes, and altered gene expression that enhance cell proliferation, invasion, and @entity3 . To accommodate deregulated cellular proliferation, many DNA replication-initiation proteins are overexpressed in @entity1 @entity5 . However, the mechanism that represses the expression of these proteins in normal cells and the cellular changes that result in their overexpression are largely unknown. One possible mechanism is through miRNA expression differences. Here, it is demonstrated that @entity17309 and @entity48634 inhibit replication licensing and the proliferation, migration, and invasion of @entity2 cells by targeting @entity22733 . Importantly, @entity17309 /b expression is significantly decreased in @entity1 @entity2 tissue specimens compared with the paired adjacent normal tissues, and @entity17309 /b downregulation and the consequential upregulation of @entity22733 are associated with poorer prognosis of @entity1 with @entity2 . These results indicate that @entity17309 /b repress replication licensing and tumorigenesis by targeting @entity22733 . IMPLICATIONS: The current study suggests that @entity17309 , @entity48634 , and @entity22733 and factors regulating their expression represent potential @entity5 diagnostic and prognostic markers as well as anticancer targets. Mol @entity5 Res; 12(11); 1-12.   2014 AACR.

title: MicroRNA-26a/b Regulate DNA Replication Licensing, Tumorigenesis, and Prognosis by Targeting @entity22733 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']


abstract: Negative mood, such as @entity308 and @entity148 , is usually associated with a decrease in sexual interest and responsiveness. In a minority of individuals, the reverse applies, often with an associated tendency to use sex as a mood regulator. In homosexual @entity1 , the prevalence of @entity308 and @entity148 states is increased, and the relationship between negative mood and sexuality is, therefore, of particular interest. A new brief instrument, The Mood and Sexuality Questionnaire, was administered to a sample of 662 gay @entity1 , with other trait measures of @entity308 and @entity148 , propensity for @entity458 seeking, and questions about sexual activity and response. Sixteen percent reported that, when @entity308 , they typically experienced increased sexual interest with 7% reporting increased capacity for erectile response; 47% and 37% reported a decrease, respectively; the remainder reported no change. When experiencing @entity148 , 24% reported that they typically experienced increased sexual interest, with 14% reporting increased responsiveness, and 39% and 31% reporting a decrease. Forty-three @entity1 were interviewed in depth. The resulting qualitative data showed @entity308 to have a more complex relationship to sexual interest than @entity148 ; other mediating mechanisms, such as need for intimacy and self-validation, were sometimes involved. Fourteen percent of those interviewed reported reduced concern about sexual risk when @entity308 . Paradoxical increases in sexual interest or activity during negative mood states are relevant to high risk sexual behavior among gay @entity1 , and deserve closer study.

title: The relation between mood and sexuality in gay XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual inhibition and sexual excitation, sensation']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: Unilateral torsion of the spermatic cord has been demonstrated to damage the contralateral testis; however, the pathogenesis has not yet been examined in detail. The purpose of this study was to evaluate the influence of unilateral torsion on the contralateral testis in @entity35 by performing @entity717 (GFN) and/or late orchiectomy. Male 25-day-old, prepubertal @entity35 albino @entity35 were divided into five groups: (1) sham operation; (2) unilateral @entity4115 ; (3) simultaneous unilateral @entity4115 and ipsilateral GFN division; (4) unilateral @entity4115 and orchiectomy on the 4th day after torsion; and (5) simultaneous unilateral @entity4115 and GFN ipsilateral division, and orchiectomy on the 4th day after torsion. Torsions performed were 720 degrees, all on the right testes. On day 55 after torsion, which represents the early postpubertal period of the @entity35 , the contralateral testes were removed. Tubular biopsy score (TBS) was calculated, and @entity4434 ( @entity4434 ) were measured. Student's t-test was used for statistical analysis. There was no contralateral testicular damage in the control group, but in all of the study groups destructive changes were found in the left gonad after torsion of the right testicle. The mean TBS of the study groups was higher than that of the control group. @entity4434 values were lower in the study groups, but the differences were not statistically significant between groups. In prepubertal @entity35 , unilateral torsion causes histologically measurable changes in the contralateral testis. Ipsilateral division of the GFN and late orchiectomy did not cause any significant alterations in terms of @entity16 . Further investigations are needed to determine the role of the GFN in @entity4115 .

title: Division of the genitofemoral nerve and late orchiectomy: effects on the contralateral testis in XXXX .

entities_list: @entity4115 :: ('MESH:D013086', 'Disease') :: ['testicular torsion']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['contralateral damage']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['ipsilateral division of the genitofemoral nerve']

entities_list: @entity4434 :: ('MESH:D005198', 'Disease') :: ['STD', 'seminiferous tubular diameters']

answer: @entity4115 :: (MESH:D013086,Disease) :: ['ipsilateral testicular torsion']


abstract: PURPOSE: Expression of @entity1722 and/or @entity470 ( @entity470 ) is associated with biologic @entity146 and poor prognosis in @entity5 ( @entity5 ). This phase II study was conducted to determine the antitumor activity of @entity9433 , a dual inhibitor of @entity470 and @entity1722 @entity669 kinase activity, in @entity5 . @entity1 AND METHODS: @entity1 with progressive, recurrent, or metastatic @entity2347 ( @entity2347 ) immunohistochemically expressing at least 1+ @entity470 and/or 2+ @entity1722 were treated with @entity9433 1,500 mg daily, in a two-stage cohort. @entity1 with non- @entity2347 @entity5 were treated as a separate single-stage cohort. RESULTS: Of 62 @entity1 screened, 29 of 33 (88%) @entity2347 and 28 of 29 (97%) non- @entity2347 @entity1 expressed @entity470 and/or @entity1722 . Forty @entity1 with @entity74 were enrolled onto the study. Among 19 assessable @entity2347 @entity1 , there were no objective responses, 15 @entity1 (79%) had @entity66 ( @entity66 ), nine @entity1 (47%) had @entity66 > or = 6 months, and four @entity1 (21%) had @entity74 ( @entity74 ). For 17 assessable non- @entity2347 @entity1 , there were no objective responses, eight @entity1 (47%) had @entity66 , four @entity1 (24%) had @entity66 > or = 6 months, and nine @entity1 (53%) had @entity74 . The most frequent adverse events were grade 1 to 2 @entity294 , @entity1295 , and @entity1910 . Eight paired @entity5 biopsies for correlative studies were procured; results did not correlate with clinical outcome. CONCLUSION: Although no responses were observed, @entity9433 was well tolerated, with prolonged @entity5 stabilization of > or = 6 months in 36% (95% CI, 21% to 54%) of assessable patients. The antitumor effects of @entity9433 in MGSTs appear mainly cytostatic, hence evaluation of other molecular targeted agents, or combinations with @entity9433 , may be considered. Continued efforts should be made to gain better understanding into the biology of this heterogeneous group of @entity5 .

title: Phase II study of XXXX in recurrent or metastatic @entity470 and/or @entity1722 expressing @entity2347 and non @entity2347 malignant @entity5 of the salivary glands.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['SD', 'stable disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor', 'EGFR']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'malignant salivary gland tumors', 'MSGTs', 'tumor']

entities_list: @entity9433 :: ('MESH:C490728', 'Chemical') :: ['lapatinib']

entities_list: @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma', 'ACC']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['PD', 'progressive disease']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity9433 :: (MESH:C490728,Chemical) :: ['lapatinib']


abstract: UNASSIGNED: Introduction. @entity14507 is available as a supplement in the United States for " @entity5 prevention" and "augmentation of physical fitness." A derivative of @entity103 found in plants, @entity13589 , binds to receptors associated with the sex @entity479 pathways and has unclear effects on @entity172 and @entity342 physiology. We present a @entity1 who had been taking @entity13589 and developed right lower extremity @entity1150 and @entity1151 . Case Presentation. A 65-year-old @entity1 presented with @entity4 , erythema, and warmth of his right lower extremity for three to four weeks. He had been taking @entity13589 one tablet daily for three to four months. Risk factors for @entity1211 included @entity286 use, personal history of possible @entity1151 , body mass index, and age. Imaging studies found extensive @entity1150 in his right lower extremity and @entity1151 with probable right middle lobe @entity1188 . Follow-up imaging showed chronic @entity1150 in his right lower extremity. Discussion. As suggested in this single case, @entity1 who take @entity13589 may be at greater risk for @entity1211 . Further reports and studies are necessary in order to elucidate this possible association. Clinicians should question @entity1 about supplements in the setting of @entity1211 .

title: A Possible Association of XXXX with Pulmonary Embolism and @entity1150 .

entities_list: @entity14507 :: ('MESH:C016392', 'Chemical') :: ["3,3'-Diindolylmethane"]

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['bilateral pulmonary embolism', 'pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis']

entities_list: @entity103 :: ('MESH:C016517', 'Chemical') :: ['indole-3-carbinol']

entities_list: @entity13589 :: ('MESH:C444299', 'Chemical') :: ['diindolylmethane']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']

answer: @entity13589 :: (MESH:C444299,Chemical) :: ['Diindolylmethane']


abstract: PURPOSE: The purpose of this study was to report two unusual cases of retinal @entity2477 in conjunction with retinal macrovessels. METHODS: Observational case study. Two @entity1 with unilateral retinal @entity2477 and no signs or symptoms of @entity262 were evaluated with full ophthalmic examination and underwent fundus photography and @entity941 angiography. RESULTS: @entity1 1 had 20/20 visual acuity bilaterally and a normal funduscopic examination of the right eye. The left eye showed diffuse clusters of @entity439 associated with a dilated superotemporal venous arcade that crossed the horizontal raphe temporally. @entity1 2 had 20/30 visual acuity in the right eye and 20/20 visual acuity in the left eye. Funduscopic examination of the left eye was normal, but the right eye demonstrated multiple clusters of saccular dilations along the course of a dilated inferior retinal vein that crossed the horizontal raphe temporally. On @entity941 angiography, both @entity1 had fluid-erythrocyte levels within the @entity439 and areas of capillary nonperfusion anterior to the @entity5 . CONCLUSION: Retinal cavernous @entity2695 is a rare @entity4607 that is typically isolated. However, it may be associated with other major @entity989 pattern. The authors describe two unique cases of a retinal cavernous @entity2695 in conjunction with a retinal macrovessel.

title: XXXX associated with retinal macrovessels.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['saccular aneurysms']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['abnormalities of the retinal vascular']

entities_list: @entity2477 :: ('MESH:D006392', 'Disease') :: ['cavernous hemangiomas']

entities_list: @entity4607 :: ('MESH:D006222', 'Disease') :: ['hamartoma']

answer: @entity2477 :: (MESH:D006392,Disease) :: ['Cavernous hemangioma']


abstract: This prospective study examines bone density and structure over a two-year time period in @entity1 with @entity1278 ( @entity1278 ) under @entity1017 treatment. Twenty-four @entity1 with @entity1278 were examined at baseline and at two annual follow-up examinations. In 9 @entity1278 @entity1 BMI increased whereas in 15 it remained unchanged or decreased. Dual energy X-ray absorptiometry (DXA) was performed on the lumbar spine, the femoral neck and the whole hip and three-dimensional peripheral quantitative computer tomography (3D-pQCT) was performed on the ultradistal radius. ANOVAs for repeated measures were used to examine change over time in BMI and bone parameters. At baseline, @entity1 with increased BMI had significantly higher bone density of femoral neck and total hip, and higher levels in all 3D-pQCT parameters of the ultradistal radius, compared to the group with unchanged or decreased BMI. The two groups did not differ at baseline in bone density of the spine. ANOVAs showed that bone density of the total hip increased significantly and that overall bone density (D100), the density of the trabecular area (D.Trab.) and the cortical thickness (C.Th.) in the ultradistal radius decreased significantly. Group x time interactions showed that changes over time were different in the two groups with regard to spine density and in the parameters D100, D.Trab. and C.Th. of the ultradistal radius. In the group with increased BMI the spine density dropped at the first follow-up whereas at the second follow-up it rose again to baseline. @entity1 with unchanged or decreased BMI showed a small but steady increase in spine density. The group changes of D100, D.Trab. and C.Th. of the ultradistal radius all followed the same pattern. Bone mineral density at all locations measured with both technologies (DXA and 3D-pQCT) did not vary according to BMI changes. The course of bone density and structure at different locations was different, and, despite weight increase, bone regain appeared to need different time periods.

title: Does XXXX induce cortical and trabecular bone @entity1278 ? A two-year prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa', 'AN']

answer: @entity1017 :: (MESH:D015430,Disease) :: ['weight gain']


abstract: Sustained increases in mucosal surface area occur in remaining bowel following massive @entity393 . The mechanisms responsible for expanding and perpetuating this response are not presently understood. We hypothesized that an increase in the number of intestinal stem cells (ISC) occurs following intestinal resection and is an important component of the adaptive response in @entity19 . This was assessed in the jejunum of @entity19 2-3 days, 4-5 days, 6-7 days, 2 wk, 6 wk, and 16 wk following ileocecal resection (ICR) or sham operation. Changes in ISC following ICR compared with sham resulted in increased crypt fission and were assayed by 1) putative ISC population (SP) by flow cytometry, 2) @entity64430 immunohistochemistry, and 3) @entity1603 ( @entity1603 ) label retention. Observed early increases in crypt depth and villus height were not sustained 16 wk following operation. In contrast, long-term increases in intestinal caliber and overall number of crypts per circumference appear to account for the enhanced mucosal surface area following ICR. Flow cytometry demonstrated that significant increases in SP cells occur within 2-3 days following resection. By 7 days, ICR resulted in marked increases in crypt fission and @entity64430 immunohistochemistry staining. Separate label-retention studies confirmed a 20-fold increase in @entity1603 incorporation 6 wk following ICR, confirming an overall increase in the number of ISC. These studies support that expansion of ISC occurs following ICR, leading to an overall increase number of crypts through a process of fission and intestinal dilation. Understanding the mechanism expanding ISCs may provide important insight into management of intestinal failure.

title: Expansion of intestinal stem cells associated with long-term adaptation following ileocecal resection in XXXX .

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['intestinal loss']

entities_list: @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', 'bromodeoxyuridine']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: STUDY DESIGN: In vitro studies using isolated @entity840 spinal cord. OBJECTIVES: To develop an alternative model using isolated @entity840 spinal cord, which can be used to screen antioxidants for in vivo SCI treatment. SETTING: Department of Basic Medical Sciences, Purdue University, West Lafayette, Indiana, USA. METHODS: The @entity2850 was induced by a constant-displacement of 5-s compression of spinal cord using a modified forceps possessing a spacer. Reactive @entity26 species (ROS) were evaluated using three distinct methods: fluorescence microscopy, lipid peroxidation assay, and flow cytometry. RESULTS: The injury-mediated ROS increases are comparable with other in vivo studies and consistent with our previous observation using a similar injury model and measured with electrophysiological and anatomical technique. Further, @entity620 , @entity2332 , or the combination of both significantly suppressed @entity224 and lipid peroxidation. The combination treatment was the most effective when compared with @entity620 or @entity2332 alone. CONCLUSION: This in vitro model has the advantage of replicating some of the in vivo conditions while gaining the ability to control the experimental conditions. This in vitro model is suitable to study the mechanisms of ROS generation and degradation and can also be used to critically evaluate the effective suppressor of ROS in the contents of spinal cord @entity130 .

title: The increase of reactive @entity26 species and their inhibition in an isolated XXXX spinal cord compression model.

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['ascorbic acid']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['compression injury']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

answer: @entity840 :: (10141,Species) :: ['guinea pig']


abstract: BACKGROUND: @entity56 to rapeseed pollen allergens was described as the result of @entity2915 with various pollens that could constitute an aggravating factor in birch or grass pollen @entity566 . Recently, a few rapeseed pollen allergens were described. The aim of the present work was to identify new rapeseed pollen allergens by using two-dimensional gel analysis, microsequencing, and mass spectrometry. METHODS: Water extractable proteins from @entity4335 pollen or stamen were separated by two-dimensional gel electrophoresis. The proteins were then electroblotted onto a nitrocellulose (NC) sheet. The NC sheets were successively incubated with (1) individual @entity1 sera pre-selected for their @entity9416 ( @entity9416 ) reactivity to rapeseed pollen proteins, (2) alkaline phosphatase (AP)-conjugated goat anti-human @entity9416 and (3) AP substrate. The allergens localized by this method were then identified by microsequencing and MALDI-TOF mass spectrometry analysis. RESULTS: Of the 18 sera studied, five recognized a wide multispot zone with a molecular mass around 43 kD and pIs between 6.5 and 8.5. The results obtained with two representative sera are shown. From this zone, two isoforms of the @entity63725 enzyme were identified by microsequencing. Confirmation was obtained through MALDI-TOF mass spectrometry analysis. CONCLUSION: The present results allow the identification of a new rapeseed allergen that can be the main allergen for some @entity1 .

title: @entity63725 (pectinase), a new XXXX allergen.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity4335 :: ('3708', 'Species') :: ['oilseed rape']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['a cross-sensitization']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['Type I hypersensitivity']

entities_list: @entity9416 :: ('3497', 'Gene') :: ['immunoglobulin E', 'IgE']

answer: @entity4335 :: (3708,Species) :: ['oilseed rape']


abstract: Background. @entity772 survivors after @entity1167 are treated with mild induced @entity2332 and potent platelet- inhibiting drugs after coronary stenting. Previous studies have shown an increased incidence of stent @entity715 during @entity1397 and @entity117 treatment in conjunction with induced @entity2332 . The aim of this study was to investigate the in vitro effect of induced hypo- and @entity221 on blood from @entity1 undergoing ticagrelor- and @entity117 -mediated platelet inhibition. Methods. Whole blood from 15 @entity1 with @entity1187 who were treated with @entity3077 and @entity117 and from eight healthy volunteers was incubated for 1 hour at 28, 33, 37, and 39  C. Results. In blood from @entity1 with @entity1187 , the activated clotting time (Sonoclot) was prolonged in mild hypothermic (33  C) compared to normothermic (37  C) samples. Sonoclot, clotting rate and platelet function were decreased in hypothermic compared to normothermic samples. Platelet-induced activation and aggregation (Multiplate(  )) was unchanged in mild hypothermic compared to normothermic samples. In contrast, mild @entity2332 supported increased platelet activation as measured with flow cytometry with up-regulation of @entity23022 and @entity8729 on the platelet surface. Conclusion. In @entity1187 @entity1 treated with ticagrelor and @entity117 , in vitro @entity2332 to 33  C markedly increased platelet activity measured with flow cytometry, whereas @entity3459 test (Sonoclot) revealed a hypocoagulative response. Prospective clinical trials studying platelet inhibition at different temperatures and correlating changes in platelet function to @entity548 or stent occlusion are needed.

title: Temperature effects on haemostasis in whole blood from ticagrelor- and XXXX -treated @entity1 with @entity1187 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['Comatose']

entities_list: @entity3077 :: ('MESH:C503700', 'Chemical') :: ['ticagrelor']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['viscoelastic coagulation']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']

answer: @entity117 :: (MESH:D001241,Chemical) :: ['aspirin']


abstract: @entity2867 ( @entity2867 ) remains one of the most lethal @entity1 @entity5 . We hypothesized that @entity2857 , a multikinase inhibitor of the @entity13723 , @entity11132 , and platelet-derived growth factor receptor-beta kinase, would decrease @entity5 growth and angiogenesis in an orthotopic model of @entity2867 . The in vitro antiproliferative and proapoptotic effects of @entity2857 on @entity2867 cell lines were examined. To study the in vivo effects of @entity2857 on orthotopic @entity2867 @entity5 in @entity19 , @entity2857 was given p.o. at 40 or 80 mg/kg daily. Intratumoral effects were studied using immunohistochemical analysis. The effect of @entity2857 on survival of the @entity19 was also studied. @entity2857 inhibited the in vitro proliferation of @entity2867 cell lines. @entity2857 also significantly inhibited @entity5 angiogenesis via the induction of endothelial apoptosis in an orthotopic model of @entity259 . As result, the growth of orthotopic @entity2867 xenografts was reduced and the survival of the test animals was improved. @entity2857 exerts significant antitumor activity in an orthotopic xenograft model of @entity2867 via a potent antiangiogenic effect. The antiangiogenic effects of @entity2857 suggest that its use in clinical setting may not depend on the @entity13723 mutational status of @entity259 . Given the lack of curative options for @entity1 with @entity2867 , @entity2857 warrants further study as a therapeutic agent against @entity2867 .

title: @entity2857 inhibits the angiogenesis and growth of orthotopic anaplastic XXXX xenografts in @entity19 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity11132 :: ('16542(Tax:10090)', 'Gene') :: ['vascular endothelial growth factor receptor-2']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'tumors']

entities_list: @entity2857 :: ('MESH:C471405', 'Chemical') :: ['sorafenib', 'Sorafenib']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors', 'thyroid cancer']

entities_list: @entity2867 :: ('MESH:D065646', 'Disease') :: ['ATC', 'Anaplastic thyroid carcinoma']

answer: @entity259 :: (MESH:D013964,Disease) :: ['thyroid carcinoma']


abstract: AIMS: Chronic foot shock has been demonstrated to induce @entity101 . The present study was designed to explore whether the @entity3449 -angiotensin system (RAS) plays a role in this process and the possible mechanisms involved in chronic-foot-shock-induced @entity101 . MAIN METHODS: Male @entity35 were subjected to a two-week foot shock with or without an angiotensin II (Ang II) type 1 receptor blocker (ARB, @entity1564 ) or an angiotensin I converting enzyme inhibitor (ACEI, @entity3371 ). The expression of RAS components in the central nervous and circulatory systems was examined. Antioxidant levels in the plasma were monitored. KEY FINDINGS: Two-week foot shock significantly increased systolic blood pressure (SBP). Angiotensinogen, @entity1811 , @entity13928 , angiotensin type 1a and type 1b receptors, and vasopressin (VAP) mRNA expression in the cerebral cortex and hypothalamus were increased along with the concentration of @entity53725 in the plasma; these changes were accompanied by decreased @entity2041 peroxidase activity and increased lipid peroxidation levels and plasma @entity2819 concentrations. Both @entity1564 and @entity3371 suppressed not only the increases in SBP but also the increases in VAP expression in the hypothalamus and RAS components in the central nervous system and the circulatory system. The decreases in antioxidant levels and the increases in lipid peroxidation and @entity2819 levels were also partially reversed by @entity1564 or @entity3371 treatment. SIGNIFICANCE: Chronic foot shock increases expression of the main RAS components, which play an important role in the development of @entity101 through increased VAP levels, oxidative stress levels and stress hormone levels.

title: Contribution of the @entity3449 -angiotensin system in chronic foot-shock induced XXXX in @entity35 .

entities_list: @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['angiotensin I converting enzyme (ACE)-1']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['high blood pressure', 'hypertension']

entities_list: @entity3371 :: ('CHEBI:3380', 'Chemical') :: ['captopril']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity1564 :: ('MESH:C081643', 'Chemical') :: ['candesartan']

entities_list: @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: INTRODUCTION: @entity154 is an uncommon pathology and its management poses formidable challenge especially in the presence of @entity1576 and @entity154 . In such @entity1 standard management protocols are not applicable and may require multistage procedure to minimize risk and optimize results. CASE DESCRIPTION: A 15-year-old @entity1 presented in our hospital emergency services with severe @entity1353 difficulty. She had a severe and rapidly progressing @entity85 , noted since 6  years of age, associated with severe respiratory distress requiring @entity26 and BiPAP support. She was diagnosed to have a severe and rigid @entity154 (coronal Cobb's angle: 105   and @entity1515  ) with type 1 split @entity602 with bony septum extending from T11 to L3. This leads to presentation of @entity358 with @entity1576 . As her lung condition did not allow for any major procedure, we did a staged procedure rather than executing in a single stage. Controlled axial traction by halogravity was applied initially followed by halo-femoral traction. Four weeks later, this was replaced by halo-pelvic distraction device after a posterior release procedure with asymmetric pedicle substraction osteotomies at T7 and T10. Halo-pelvic distraction continued for 4 more weeks to optimize and correct the deformity. Subsequently definitive posterior stabilization and fusion was done. The detrimental effect of @entity601 resection in such cases is clearly evident from literature, so it was left unresected. A good scoliotic correction with improved respiratory function was achieved. Three years follow-up showed no @entity85 correction, no evidence of @entity1516 and a good clinical outcome with reasonably balanced spine. CONCLUSION: The management of severe and @entity2003 with @entity154 is challenging. Progressive reduction in respiratory volume in untreated cases can lead to @entity1576 . Such @entity1 have a high rate of intraoperative and postoperative morbidity and mortality. Hence a staged procedure is recommended. Initially a less invasive procedure like halo traction helps to improve their respiratory function with simultaneous correction of the deformity, while allowing for monitoring of @entity51 . Subsequently spinal osteotomies and combined halo traction helps further improve the correction, following which definitive instrumented fusion can be done.

title: A case of severe and @entity2003 with XXXX presenting with @entity1576 : managed by staged correction with controlled axial traction.

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['intraspinal anomalies', 'Congenital lordoscoliosis', 'congenital right thoracolumbar lordoscoliosis']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigid congenital lordoscoliotic deformities']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['breathing']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['cord malformation']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity1515 :: ('MESH:D008141', 'Disease') :: ['thoracic lordosis -10']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['restrictive lung disease']

entities_list: @entity601 :: ('MESH:D009436', 'Disease') :: ['diastematomyelia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['acute respiratory failure', 'type 2 respiratory failure']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity in her back', 'loss of deformity']

entities_list: @entity1516 :: ('MESH:D011542', 'Disease') :: ['pseudarthrosis']

answer: @entity601 :: (MESH:D009436,Disease) :: ['diastematomyelia']


abstract: @entity1 with @entity2401 often develop @entity384 and @entity712 . Histologically, @entity2401 is manifested by rare foci of @entity39 with @entity32 , while @entity296 is characterized by diffuse interstitial @entity82 , @entity1184 , and an absence of active @entity32 . The relationship between @entity296 and interstitial @entity82 is poorly understood. This relationship was examined in @entity19 that developed a diffuse @entity32 of the heart over a period of 21 days following infection with @entity9258 . Typical @entity75 (day 7) included focal zones of myocytolysis containing mononuclear and polymorphonuclear inflammatory cells that were associated with the focal loss of reticular fibers. Later pathology (days 14-21) was characterized by a sparse, diffuse @entity2401 with @entity39 . Changes within the myocardial interstitium remote from healing @entity39 foci were marked by reticular fiber thickening and disorganization, often associated with pleomorphic fibroblasts. Reticulin fiber deposition was quantitatively increased in sparsely inflamed regions of hearts from infected animals as compared to noninflamed regions from the same hearts (p < 0.005) or hearts of control animals (p < 0.001). Scanning electron microscopy revealed interstitial changes that were more extensive than indicated by routine staining with @entity1710 and @entity1711 for Masson's trichrome. The progressive changes within the cardiac interstitium during the development of @entity296 suggest that direct viral infection of fibroblasts or an interaction between the interstitium and inflammatory cells and their secreted products may contribute to pathologic changes within the interstitial collagen matrix.

title: Pathologic changes in the cardiac interstitium of @entity19 infected with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['interstitial inflammation']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['postmyocarditic cardiomyopathy', 'cardiomyopathy', 'myocardial inflammation']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'little ongoing necrosis', 'myocyte necrosis']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['myocyte hypertrophy']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['early lesions']

entities_list: @entity9258 :: ('12104', 'Species') :: ['encephalomyocarditis virus']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis', 'interstitial myocarditis']

answer: @entity9258 :: (12104,Species) :: ['encephalomyocarditis virus']


abstract: BACKGROUND: There are sex differences in low-grade @entity32 markers in @entity28 . Little is known, however, about a possible sex-specific association of relative weight change from youth to adulthood with actual low-grade @entity32 . OBJECTIVE: The aim of this study was to identify possible sex differences in @entity1254 , @entity1356 ( @entity1356 ), @entity1193 ( @entity1193 ), and high-sensitivity C-reactive protein (hs-CRP) levels with respect to the relative change in body mass index (BMI) from youth to middle age. METHODS: The study population consisted of 403 @entity1 and 500 @entity1 from 1 Finnish town. Weight, height, and @entity1254 , @entity1356 , @entity1193 , and hs-CRP levels were measured in 2003 at a mean age of 46 years. Self-reported weight at the age of 20 years was recorded. RESULTS: In @entity1 , even after adjustment for BMI in adulthood, a statistically significantly negative linear association was observed between the quartiles of relative change in BMI and @entity1254 levels (P < 0.001 for linearity). Significantly positive linear associations were also observed between the change in BMI and @entity1193 (P = 0.032 for linearity) and hs-CRP (P = 0.029 for linearity) levels. In @entity1 , there was no statistically significant association among the quartiles of relative change in BMI and measured inflammatory markers after adjustment for BMI in adulthood. CONCLUSIONS: A relative increase in weight may be more harmful in @entity1 than in @entity1 with respect to @entity1254 and inflammatory markers.

title: Sex differences in the association of XXXX and low-grade @entity32 with changes in the body mass index from youth to middle age.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity-related disorders']

answer: @entity1254 :: (9370,Gene) :: ['adiponectin']


abstract: Macrophages, neutrophils and @entity281 have been implicated in the genesis of the @entity4154 ( @entity4154 ) post lung transplantation. sCD14 is a soluble form of a shed-cell surface protein. It is capable of promoting cytokine-induced @entity32 and it's presence in clinically stable lung transplant recipients (LTR) might be important as an early marker of @entity4154 . Bronchalveolar lavage (BAL) and blood samples were taken from 26 stable LTR, at or near their best forced expiratory volume in one second who were free from @entity281 . sCD14 levels were measured via enzyme-linked immunosorbent assay. Cell counts were performed on unfiltered BAL. LTR neutrophil count, BAL sCD14 and serum sCD14 levels were higher than controls (median 3.8% versus 1.3%, p<0.05; 11.5 ng x mL(-1) versus 6 ng x mL(-1), p<0.001; 6.2 microg x mL(-1) versus 2.4 microg x mL(-1), p<0.05, respectively). BAL albumin and sCD14 correlated (regression coefficient: 0.77, p<0.001). In this hypothesis-generating, cross-sectional study, the authors have described for the first time soluble @entity5750 levels in the bronchoalveolar lavage and serum of stable lung transplant recipients, and show that these are elevated compared to controls. This is a practicable candidate marker system, which can be tested for a predictive role in @entity4154 following lung transplantation. The origin of this cellular protein and its temporal relationship to the development of the @entity4154 remains to be elucidated in more definitive longitudinal studies, which should include other measurements potentially relevant to the innate immune system, such as bronchoalveolar lavage endotoxin levels.

title: Increased soluble XXXX in bronchoalveolar lavage fluid of stable lung transplant recipients.

entities_list: @entity4154 :: ('MESH:D001989', 'Disease') :: ['BOS', 'bronchiolitis obliterans syndrome']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity5750 :: (929,Gene) :: ['CD14']


abstract: BACKGROUND: @entity1 with duodenal @entity1066 have a reduced risk of developing @entity356 compared to those without. Recently, the prostate stem cell antigen (PSCA) @entity64090 @entity6344 polymorphism was found to be associated with different pathogenesis of duodenal @entity1066 and @entity356 developments. However, whether PSCA @entity64090 @entity6344 polymorphism is associated with severity of @entity356 is unclear. We examined the influence of the PSCA @entity64090 @entity6344 polymorphism on susceptibility to @entity1534 -related diseases and the relationships between PSCA polymorphism and @entity356 . METHODS: PSCA @entity64090 @entity6344 polymorphism was assessed in @entity1534 -positive Japanese @entity1 (n  =  488) with noncardia @entity356 (n  =  193), gastric @entity1066 (n  =  84), duodenal @entity1066 (n  =  61), and @entity4726 (n  =  150), as well as in @entity1534 -negatives (n  =  266). RESULTS: Frequency of PSCA @entity64090 C/C genotype in duodenal @entity1066 was 36.1%, which was significantly higher than those with @entity356 (12.4%), gastric @entity1066 (19.0%), @entity3621 (10.7%), and @entity1534 -negatives (19.5%) (p  <  .001). Compared with duodenal @entity1066 , having the T allele significantly increased the risk of @entity356 (OR: 3.97, 95% CI: 2.02-7.80; p  <  .001), gastric @entity1066 (2.40, 1.13-5.10; p  =  .023), and @entity3621 (4.72, 2.26-9.86; p  <  .001). Mean pepsinogen (PG) I/PG II ratio in T allele carriers (2.17      0.75) was significantly lower than that in C/C genotype (3.39      1.27, p  <  .001). CONCLUSIONS: The PSCA @entity64090 @entity6344 polymorphism is associated with differing susceptibilities to @entity1534 -associated diseases. The PSCA @entity64090 @entity6344 polymorphism may be acting through induction of @entity356 , finally leading to development of @entity356 in PSCA @entity64090 T allele carriers, but not duodenal @entity1066 .

title: Influence of Prostate Stem Cell Antigen Gene Polymorphisms on Susceptibility to XXXX -associated Diseases: A Case-control Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6344 :: ('c|SUB|C||T', 'DNAMutation') :: ['C>T']

entities_list: @entity4726 :: ('MESH:D005757', 'Disease') :: ['atrophic gastritis']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric mucosal atrophy', 'gastric ulcer and gastric cancer']

answer: @entity1534 :: (210,Species) :: ['Helicobacter pylori']


abstract: AIM: Monitoring of @entity428 ( @entity428 ), local cerebral blood flow (CBF) and @entity26 is part of modern intensive critical care medicine. Preclinical evaluation of newly developed catheters that should monitor several parameters simultaneously is reported poorly in the literature. The goal of our study was (1) to evaluate a new multi-parametric sensor in brain tissue and (2) to establish a testing protocol using pathophysiological challenges that target measured parameters of the sensor and autoregulatory boundaries and could be used as preclinical standard protocol in future studies. MATERIAL AND METHODS: We describe data from 12 new multi-parametric brain sensors (MPBS) that were implanted into 3 porcine brains and combined measurement of brain tissue oxygenation (ptiO < sub > 2 < /sub > ), @entity428 , CBF and brain temperature for the first time. @entity1707 were treated with a period of hyperoxygenation, @entity2944 , @entity519 , @entity452 , and @entity1063 . RESULTS: None of the 12 MPBS failed. Our testing protocol induced standardized pathophysiological changes that were picked up by the new MPBS as significant alterations in brain ptiO < sub > 2 < /sub > , @entity428 and CBF. The magnitude of changes was > 20% in most tested MPBS. CONCLUSION: An experimental protocol with pre-defined end-points for O < sub > 2 < /sub > , CO < sub > 2 < /sub > , blood pressure and cardiac output should be standardized and reported if new sensors for multi-parametric brain monitoring are evaluated. The use of several sensors per brain of only a few animals is sufficient to determine functionality of new sensors in vivo as basis for a larger study with reference sensors and @entity1545 .

title: Description of the response of a new multi-parametric brain sensor to physiological and pathophysiological challenges in the cortex of juvenile XXXX .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity2944 :: ('MESH:D006935', 'Disease') :: ['hypercapnia']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['ICP', 'intracranial pressure']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity1707 :: (9823,Species) :: ['pigs']


abstract: It is well established that @entity1928 -induced elevation of @entity268 results in activation of DNA synthesis in Schwann cell cultures. This promitotic response is partially mediated by the @entity15308 , which is required for the transition from the G1 to the S phase of the cell cycle. In the present study, we analyze the effects of @entity268 elevation in cultured Schwann cells on the transcriptional activity and on the organization of two nuclear compartments involved in pre-mRNA processing: Cajal bodies (CBs) and splicing factor compartments. Our immunofluorescence and quantitative studies show that @entity1928 treatment induces a 5.6-fold increase in the proportion of S phase Schwann cells, detected by a short pulse (20 min) of @entity1603 incorporation. This increase in DNA synthesis correlates with an activation of global transcription, as is indicated by the higher nuclear incorporation of @entity53191 in nascent RNA. @entity1928 treatment significantly increases the percentage of Schwann cells containing typical CBs, which concentrate spliceosomal snRNPs and the survival motor neuron (SMN) protein. This increase in the number of CBs closely correlates with the activation of transcription. Moreover, the occurrence of CBs is significantly higher in @entity1603 (+) cells than in @entity1603 (-) cells, indicating that entry in the S phase promotes the formation of CBs. During the S phase, Schwann cell nuclei display higher @entity15308 nuclear staining and concentrate this kinase in CBs. @entity1928 also induces a redistribution of the pre-mRNA splicing factors in Schwann cells. Primary cultures of Schwann cells provide an excellent physiological model to demonstrate that the assembly of CBs is a transcription- and replication-dependent cellular event. Moreover, the S phase accumulation of @entity15308 observed in Schwann cells supports a functional link between CBs and DNA replication, which is mediated by the possible participation of CBs in the regulatory control of histone gene expression.

title: XXXX -dependent reorganization of the Cajal bodies and splicing machinery in cultured Schwann cells.

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin', 'Forskolin']

answer: @entity268 :: (CHEBI:17489,Chemical) :: ['cAMP']


abstract: Certain protease inhibitors are effective at preventing or suppressing carcinogen-induced transformation in vitro and @entity105 in animal model systems. One protease inhibitor, the @entity1460 -derived Bowman-Birk inhibitor (BBI) is particularly effective in suppressing @entity105 . BBI is a protein of a molecular weight of 8000 with a well-characterized ability to inhibit trypsin and chymotrypsin. BBI has been extensively studied, both as purified BBI and as an extract of @entity1460 enriched in BBI called BBI concentrate (BBIC). Purified BBI and BBIC have comparable suppressive effects on the carcinogenic process in a variety of in vivo and in vitro systems. BBI appears to be a universal @entity5 preventive agent. Purified BBI and BBIC suppress @entity105 as follows: in 3 different species ( @entity19 , @entity35 , and hamsters); in several organ systems and tissue types [eg, colon, liver, lung, esophagus, cheek pouch (oral epithelium), and cells of hematopoietic origin]; and in cells of epithelial and connective tissue origin when given to animals by several different routes of administration, including the diet, leading to different types of @entity5 (eg, @entity957 , @entity420 , and @entity5426 ), and induced by various chemical and physical carcinogens. About half of an oral dose of BBI is taken up into the bloodstream and distributed throughout the body, with excretion via the urine. Pharmacokinetic studies of BBI have been performed in animals with radioactively labeled BBI, whereas antibodies that react with reduced BBI are being used in pharmacokinetic studies in @entity1 . The calculated serum half-life is 10 h in both @entity35 and hamsters. BBIC achieved Investigational New Drug status from the FDA in April 1992 (IND no. 34671; sponsor, Ann R Kennedy), and studies to evaluate BBIC as an anticarcinogenic agent in @entity1 populations began. Both BBI and BBIC prevent and suppress @entity105 in vivo without @entity137 .

title: The Bowman-Birk inhibitor from XXXX as an anticarcinogenic agent.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcomas']

entities_list: @entity1460 :: ('3847', 'Species') :: ['soybean', 'soybeans']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis', 'malignant transformation in vitro and carcinogenesis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity1460 :: (3847,Species) :: ['soybeans']


abstract: BACKGROUND: There are currently three ongoing studies on less radical surgery in cervical @entity5 : ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies retrospectively and suggest a new, simplified criterion in microscopic Stage @entity3846 cervical @entity5 . METHODS: A retrospective analysis was performed in 125 Stage @entity3846 cervical @entity5 @entity1 who had no clinically visible lesions and were allotted based on microscopic findings after conization. All @entity1 had magnetic resonance imaging (MRI) after conization and underwent type C2 radical hysterectomy. We suggested an MRI criterion for less radical surgery candidates as @entity1 who had no demonstrable lesions on MRI. The rates of parametrial involvement (PMI) were estimated for @entity1 that satisfied the inclusion criteria for ongoing studies and the MRI criterion. RESULTS: The rate of pathologic PMI was 5.6% (7/125) in the study population. ConCerv and GOG-278 identified 11 (8.8%) and 14 (11.2%) @entity1 , respectively, as less radical surgery candidates, and there were no false negative cases. SHAPE and MRI criteria identified 78 (62.4%) and 74 (59.2%) @entity1 , respectively, as less radical surgery candidates; 67 @entity1 were identified as less radical surgery candidates by both sets of criteria. Of these 67 @entity1 , only one had pathologic PMI with @entity5 emboli. CONCLUSIONS: This study suggests that the criteria used in three ongoing studies and a new, simplified criterion using MRI can identify candidates for less radical surgery with acceptable false negativity in microscopic Stage @entity3846 disease.

title: Identifying a low-risk group for parametrial involvement in microscopic Stage XXXX cervical @entity5 using criteria from ongoing studies and a new MRI criterion.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity3846 :: (9479,Gene) :: ['IB1']


abstract: @entity5 initiation and progression is controlled by both genetic and epigenetic events. Epigenetics refers to the study of mechanisms that alter gene expression without permanently altering the DNA sequence. Epigenetic alterations are reversible and heritable, and include changes in histone modifications, DNA methylation, and non-coding RNA-mediated gene silencing. Disruption of epigenetic processes can lead to altered gene function and malignant cellular transformation. Aberrant epigenetic modifications occur at the earliest stages of neoplastic transformation and are now believed to be essential players in @entity5 initiation and progression. Recent advances in epigenetics have not only offered a deeper understanding of the underlying mechanism(s) of @entity105 , but have also allowed identification of clinically relevant putative biomarkers for the early detection, disease monitoring, prognosis and risk assessment of @entity5 @entity1 . At this moment, DNA methylation and non-coding RNA including with microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) represent the largest body of available literature on epigenetic biomarkers with the highest potential for @entity5 diagnosis. Following identification of cell-free nucleic acids in systematic circulation, increasing evidence has demonstrated the potential of cell-free epigenetic biomarkers in the blood or other body fluids for @entity5 detection. In this article, we summarize the current state of knowledge on epigenetic biomarkers - primarily DNA methylation and non-coding RNAs - as potential substrates for @entity5 detection in gastric and @entity14 , the two most frequent @entity5 within the gastrointestinal tract. We also discuss the obstacles that have limited the routine use of epigenetic biomarkers in the clinical settings and provide our perspective on approaches that might help overcome these hurdles, so that these biomarkers can be readily developed for clinical management of @entity5 @entity1 .

title: DNA methylation and microRNA biomarkers for noninvasive detection of gastric and XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: @entity2210 ( @entity2210 ) is a @entity74 that presents as postprandial fullness, early satiation, or epigastric burning despite no evidence of a structural disease. Proton pump inhibitors (PPIs) are often the first choice for treating @entity2210 . However, some @entity1 need additional medication because of residual symptoms despite a certain level of benefit from the @entity7371 . For these @entity1 , a combination of @entity7371 and other agents has a possibly more beneficial effect than changing their medication. This study aimed to evaluate the efficacy of an initial @entity7371 followed by combination therapy with @entity7371 and @entity35317 in @entity2210 @entity1 with residual symptoms after an initial @entity7371 . We enrolled 105 @entity1 who started an initial @entity7371 (20 mg of @entity1537 once a day). Twenty-three @entity1 with residual symptoms received 100 mg of @entity35317 , a cholinesterase inhibitor, three times a day with @entity1537 as a combination therapy for 2 weeks. The symptoms were evaluated using the modified Frequency Scale for the Symptoms of @entity354 (mFSSG). Eighteen of 23 @entity1 (78%) achieved an overall improvement in symptoms. Almost all @entity2210 -related symptoms statistically improved after the combination therapy, with an improvement in the mFSSG score relevant to the @entity4053 and @entity158 . The symptoms improved regardless of age, sex, and the pre-combination therapy score of the mFSSG. Our findings suggest that the combination therapy of @entity35317 and @entity7371 may be effective in selected @entity2210 @entity1 with insufficient improvement with an initial @entity7371 . However, well-designed trials are required to confirm the efficacy.

title: Efficacy of XXXX in combination with @entity1537 for functional @entity2210 refractory to proton-pump inhibitor monotherapy.

entities_list: @entity1537 :: ('MESH:D064098', 'Chemical') :: ['esomeprazole']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['postprandial distress syndrome']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['gastroduodenal disorder']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['FD', 'Functional dyspepsia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['Gastroesophageal Reflux Disease']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain syndrome']

entities_list: @entity35317 :: ('MESH:C410959', 'Chemical') :: ['acotiamide']

answer: @entity35317 :: (MESH:C410959,Chemical) :: ['acotiamide']


abstract: Transformed @entity2704 (TM) is one of the most frequent types of chronic @entity2794 . Eighty @entity1 : 40 with @entity2749 @entity2704 (EM) and 40 with TM with ages ranging from 18 to 60 years old were studied. Females were the majority. At first examination, the mean age was similar in both groups. The initial age of @entity2704 attacks was significantly smaller in the TM group. Time history of @entity2749 attacks was similar in both groups. In the EM group, the @entity10 was predominantly located on only one side of the head; whereas in the TM group, on more than one side. There was variation in the character of @entity158 and intensity in the TM group. @entity302 with @entity10 , aura and family history did not show significant association with EM or TM. The TM was distinguished from the EM in relation to the frequency, location and @entity158 intensity of the @entity10 . @entity1 with early @entity2704 @entity10 onset may exhibit a further risk of developing TM.

title: Clinical features of @entity2749 @entity2704 and transformed XXXX : a comparative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2794 :: ('MESH:D020773', 'Disease') :: ['daily headache']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Nocturnal awakening']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity2704 :: (MESH:D008881,Disease) :: ['migraine']


abstract: We report the outcomes of 20 @entity1 (12 @entity1 , 8 @entity1 , 21 feet) with Charcot neuro- @entity2720 who underwent correction of @entity85 of the ankle and hindfoot using retrograde intramedullary nail arthrodesis. The mean age of the @entity1 was 62.6 years (46 to 83); their mean BMI was 32.7 (15 to 47) and their median American Society of Anaesthetists score was 3 (2 to 4). All presented with severe @entity85 and 15 had chronic @entity1066 . All were treated with reconstructive surgery and seven underwent simultaneous midfoot fusion using a bolt, locking plate or a combination of both. At a mean follow-up of 26 months (8 to 54), limb salvage was achieved in all @entity1 and 12 @entity1 (80%) with @entity1066 achieved healing and all but one @entity1 regained independent mobilisation. There was failure of fixation with a broken nail requiring revision surgery in one @entity1 . Migration of distal locking screws occurred only when standard screws had been used but not with hydroxyapatite-coated screws. The mean American Academy of Orthopaedic Surgeons Foot and Ankle (AAOS-FAO) score improved from 50.7 (17 to 88) to 65.2 (22 to 88), (p = 0.015). The mean Short Form (SF)-36 Health Survey Physical Component Score improved from 25.2 (16.4 to 42.8) to 29.8 (17.7 to 44.2), (p = 0.003) and the mean Euroqol EQ  -5D  -5L score improved from 0.63 (0.51 to 0.78) to 0.67 (0.57 to 0.84), (p = 0.012). Single-stage correction of deformity using an intramedullary hindfoot arthrodesis nail is a good form of treatment for @entity1 with severe Charcot @entity85 , @entity1066 and instability provided a multidisciplinary care plan is delivered. Cite this article: Bone Joint J 2015;97-B:76-82.

title: Outcome of one-stage correction of XXXX of the ankle and hindfoot and fusion in Charcot neuroarthropathy using a retrograde intramedullary hindfoot arthrodesis nail.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformities', 'hindfoot deformity']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthropathy']

answer: @entity85 :: (MESH:D009140,Disease) :: ['deformities']


abstract: BACKGROUND: Although most RNA-binding proteins recognize a complex set of structural motifs in their RNA target, the double-stranded (ds) RNA-binding proteins are limited to interactions with double helices. Recently, it has been discovered that some dsRNA-binding proteins share regions of @entity535 similarity known as dsRNA-binding motifs. RESULTS: A @entity1238 ovary cDNA expression library was screened with radiolabeled dsRNA to identify previously uncharacterized dsRNA-binding proteins. The analysis of an incomplete cDNA identified during the screen led to the discovery of two longer cDNAs of related sequence. The proteins encoded by these cDNAs each contained two dsRNA-binding motifs, in @entity2228 . The nucleic-acid-binding properties of a fusion protein containing the two dsRNA-binding motifs and the auxiliary domain were analyzed using a gel mobility shift assay. The fusion protein bound dsRNA of a variety of different sequences, and exhibited a preference for binding to dsRNA and RNA-DNA hybrids over other nucleic acids. Appropriate mRNAs, corresponding to each cDNA, were detected in polyadenylated RNA isolated from @entity1238 stage VI oocytes, but translation of one of the mRNAs appeared to be masked until meiotic maturation. CONCLUSION: dsRNA-binding motifs are often found in proteins that bind dsRNA, and our results show that they can be associated with auxiliary domains rich in @entity369 and @entity2228 . These motifs can confer very tight binding to dsRNA. Binding can also occur to RNA-DNA hybrids, suggesting recognition of some aspect of the A-form helical structure that is adopted by both dsRNA and RNA-DNA hybrids.

title: Binding properties of newly identified XXXX proteins containing dsRNA-binding motifs.

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino-acid']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

entities_list: @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']

answer: @entity1238 :: (8355,Species) :: ['Xenopus']


abstract: The @entity1028 ( @entity1028 ) is a silent and often @entity455 caused by the localized weakening of the arterial wall. Previous work has indicated that local changes in wall stiffness can be detected with pulse wave imaging (PWI), which is a non-invasive technique for tracking the propagation of pulse waves along the aorta at high spatial and temporal resolutions. The aim of this study was to assess the capability of PWI to monitor and stage @entity1028 progression in a @entity19 model of the disease. @entity6970 / @entity5779 knockout @entity19 (N = 18) were given angiotensin II for 30 days via subcutaneously implanted osmotic pumps. The suprarenal sections of the abdominal aortas were imaged every 2-3 d after implantation using a 30-MHz VisualSonics Vevo 770 with 15- m lateral resolution. Pulse wave propagation was monitored at an effective frame rate of 8 kHz by using retrospective electrocardiogram gating and by performing 1-D cross-correlation on the radiofrequency signals to obtain the displacements induced by the waves. In normal aortas, the pulse waves propagated at constant velocities (2.8    0.9 m/s, r(2) = 0.89    0.11), indicating that the composition of these vessels was relatively homogeneous. In the @entity19 that developed @entity20719 (N = 10), the wave speeds in the @entity439 sac were 45% lower (1.6    0.6 m/s) and were more variable (r(2) = 0.66    0.23). Moreover, the wave-induced wall displacements were at least 80% lower within the sacs compared with the surrounding vessel. Finally, in @entity19 that developed fissures (N = 5) or @entity397 (N = 3) at the sites of their @entity1028 , higher displacements directed out of the lumen and with no discernible wave pattern (r(2) < 0.20) were observed throughout the cardiac cycle. These findings indicate that PWI can be used to distinguish normal @entity19 aortas from aneurysmal, fissured and ruptured ones. Hence, PWI could potentially be used to monitor and stage @entity1 @entity439 by providing information complementary to standard B-mode ultrasound.

title: Monitoring and staging XXXX with pulse wave imaging.

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['deadly vascular disease']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptures']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm disease']