abstract: OBJECTIVE: To evaluate the joint effect of cigarette smoking and @entity167 consumption on mortality. METHODS: A population-based cohort of 66,743 Chinese @entity1 aged 30-89 in Shanghai, China recruited from 1996 to 2000. Lifestyle data were collected using structured questionnaires. As of November 2004, follow-up for the vital status of 64,515 @entity1 was completed and @entity204 information was further confirmed through record linkage with the Shanghai Vital Statistics Registry. Associations were evaluated by Cox regression analyses. RESULTS: 2514 deaths (982 from @entity5 , 776 from @entity65 ( @entity65 )) were identified during 297,396 @entity1 -years of follow-up. Compared to never-smokers, both former and current smokers had significantly elevated mortality from any cause, @entity65 , and @entity5 ; risk increased with amount of smoking. Intake of 1-7 drinks/week was associated with reduced risk of @entity204 , particularly @entity65 @entity204 (hazard ratio (HR): 0.7, 95% confidence interval (CI): 0.5, 1.0), whereas intake of >42 drinks/week was related to increased mortality, particularly @entity5 (HR: 1.7, 95% CI: 1.1, 2.5). The HR for total mortality associated with moderate @entity167 consumption increased from 0.8 (95% CI: 0.6, 1.0) for non-smokers to 1.0 (0.9, 1.2) for moderate smokers and 1.4 (95% CI: 1.2, 1.7) for heavy smokers. Heavy drinkers and heavy smokers had the highest mortality (HR: 1.9, 95% CI: 1.6, 2.4). CONCLUSIONS: Light and moderate @entity167 consumption reduced mortality from @entity65 . This beneficial effect, however, was offset by cigarette smoking.

title: Joint effect of cigarette smoking and XXXX consumption on mortality.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-related death', 'cancers', 'cancer']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular diseases']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']


abstract: A population of 33 subjects were selected on the basis that all had tested positive for A, actinomycetemcomitans at some time during the prior 7 years. Most subjects (31/33) belonged to families with a proband with confirmed localized @entity6223 ( @entity6223 ); however, most subjects had no evidence of the typical lesions associated with @entity6223 . Two additional subjects with rapidly progressive @entity2521 , known to be positive for A. actinomycetemcomitans, were also recruited. The @entity1 with a history of @entity6223 had been treated, but were no longer enrolled in a regular maintenance program. With 3 exceptions, the subjects had not received any dental treatment or antibiotics in the past 3 months. One aim of the study was to determine the prevalence of A. actinomycetemcomitans, @entity2523 , and @entity3289 in this population. The main purpose was to compare the relative sensitivity of various methods for detecting these periodontal pathogens. Pooled @entity527 samples were collected from all the mesial surfaces and aliquots of the suspension processed for the detection of A. actinomycetemcomitans by culture and indirect immunofluorescence (IF) to serotypes a, b, and c. P. gingivalis and @entity3289 were monitored with a DNA probe and IF. With culture, A. actinomycetemcomitans was detected in 39.4% of the samples, at a mean level of 0.64% of the cultivable counts. With IF, A. actinomycetemcomitans was detected in 81.8% of the samples, at levels of 0.40, 0.79, and 0.17% of the total counts for serotypes a, b and c respectively. Overall, IF was more likely to detect A. actinomycetemcomitans, @entity2523 , and @entity3289 than any of the other methods.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Detection of Actinobacillus actinomycetemcomitans, @entity2523 , and XXXX in an A. actinomycetemcomitans-positive @entity1 population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['subgingival plaque']

entities_list: @entity6223 :: ('MESH:D010520', 'Disease') :: ['JP', 'juvenile periodontitis']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

entities_list: @entity2523 :: ('837', 'Species') :: ['P. gingivalis']

answer: @entity3289 :: (28112,Species) :: ['Bacteroides forsythus']


abstract: PURPOSE: @entity674 ( @entity674 ) are rare neoplasms, 1-3% of malignant @entity1820 . They are immature proliferations of spindled and/or epithelioid cells, developed in the muscular layer of the digestive tract, showing uncompleted or partial muscular, nervous or mixed differentiation. Immunohistologic knowledge about these @entity5 has recently progressed because of the discovery of specific markers (coexpression @entity2277 - @entity2467 , oncogenes): @entity674 can now be distinguished from the other @entity361 . METHODS: Retrospective study of seven @entity1 with @entity674 who received the same treatment. RESULTS: For our seven @entity1 the mean age was 49 years with a male predominance (sex-ratio 4/3). The tumoral localisations are principally the small bowel (four cases), the rectum (two cases) and the stomach (one case). The treatment consisted of a first surgery, adapted to the tumoral localisation and extension, associated to chemotherapy in case of @entity3 or local recurrence. The study of the histological grading for the seven @entity1 showed @entity5 with poor prognoses. Six @entity1 developed recurrence in a 2-year period; for the survey we are too close for a proper view. CONCLUSIONS: A review of the literature on @entity5 finds older @entity1 (59 years) with an equal sex ratio. Against the results of our series, the most frequent location is the stomach (50%). But the main problem is the better understanding of the particular evolution of these @entity5 . The bad short-date prognosis imposes carrying out larger studies, in order to confirm the principal hypothesis of histogenesis and to improve the survey by an optimal treatment.

title: [Current findings on @entity674 : seven observations of XXXX ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stromal tumors', 'tumors']

entities_list: @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['GIST', 'Gastrointestinal stromal tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant tumors']


abstract: A review of the literature often fails to uncover the best procedure for the treatment of @entity7769 . This article compares 2 frequently used methods (subcutaneous anterior transposition vs decompression and medial epicondylectomy) for their effectiveness in relieving both subjective and objective symptoms of @entity7769 . Between August 1991 and October 1993, nineteen @entity1 underwent surgical decompression by a single surgeon for @entity16 at the elbow. Factors evaluated included @entity2045 , grip strength, pinch, 2-point discrimination, and pre- and postoperative nerve conduction. A standardized questionnaire was administered to assess subjective relief of symptoms.In the transposition group, grip strength averaged 71.2% of normal and pinch strength 86.6% of normal, and 2-point discrimination averaged 8.0 mm. The derived subjective assessment score was 23.2 of a possible 40. The average ulnar motor conduction velocity across the elbow was 50.1 m/sec preoperatively and 56.3 m/sec postoperatively. In the medial epicondylectomy group, grip strength averaged 79.5% of normal and pinch strength 81.7% of normal, and 2-point discrimination averaged 8.0 mm. The average ulnar motor conduction velocity across the elbow was 45.7 m/sec preoperatively and 55.7 m/sec postoperatively. No statistically significant difference existed between the 2 groups for the aforementioned indexes. These results do not indicate a difference between the outcomes of the @entity1 undergoing either of the procedures. Because epicondylectomy is less technically demanding, with less soft tissue dissection of the nerve, it may be preferred over ulnar transposition.

title: Subcutaneous anterior transposition versus decompression and medial epicondylectomy for the treatment of XXXX .

entities_list: @entity7769 :: ('MESH:D020430', 'Disease') :: ['cubital tunnel syndrome']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity range of motion, elbow valgus stress']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['ulnar neuropathy']

answer: @entity7769 :: (MESH:D020430,Disease) :: ['cubital tunnel syndrome']


abstract: Searching for risk groups with @entity1593 is an interdisciplinary problem, and therefore it requires the co-operation of all branches of medicine. It has been suggested that the determination of antiendomysial antibody (AEA) and @entity8265 ( @entity8265 ) should be performed by doctors in the first-contact medical facilities. In diagnosed @entity1 , and especially in paediatric practice, it the values of autoantibodies regarding the adherence to a gluten-free diet should be monitored. After reaching the adulthood, @entity1 should be entrusted to the care of gastroenterologists. Biopsy of duodenum samples remains the golden standard for the diagnosis of @entity1593 . Every histological examination of a duodenum sample must be completed by histological grading in accordance to Marsh-Oberhuber. Histochemical investigation should be an inseparable part of the malabsorption diagnostics in biopsy. In controversial biopsies, such as a biopsy with minimal or mild pathological changes, application of antibodies to the intraepithelial lymphocytes is recommended. It is also useful to perform electron-microscopy of duodenum samples as well, when repeated biopsies are negative, but the @entity1 's troubles persist (Ref. 32).

title: What can we do to promote the recognition of XXXX : a report on diagnostic strategies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease']

entities_list: @entity8265 :: ('7052', 'Gene') :: ['t-TG', 'tissue transglutaminase']

answer: @entity1593 :: (MESH:D002446,Disease) :: ['celiac disease']


abstract: The developmental expression of neural and cell proliferation-related antigens in guts from mutant @entity19 embryos (Is, lethal spotted) as a model for @entity1963 was studied. The expression was examined immunohistochemically using antibodies specific for @entity4497 ( @entity4497 ), the L1 molecule, and @entity4698 ( @entity4698 ). Cells immunoreactive for neural components proceeded from the esophagus to the anorectum showing a one-way migratory wave between embryonal day 10 (E10) and E14 in control specimens (Is/+, +/+). The patterns of @entity4497 and L1 immunoreactivity in Is/Is mutant specimens was the same as in controls on E10. However, from E10.5 to E13.5, the immunoreactivity in the mutants decreased and remained in the more oral side as compared with controls. No migration of immunoreactivity was found after E14.0. Therefore, the terminal portion of the colon remained aganglionic in Is/Is mutant embryos. @entity4698 immunoreactivity of mesenchymal cells preceded the migratory wave of the neural specific immunoreactivity, but the @entity4698 -positive cells were meager and poorly organized in the mutant embryos. Deficient @entity4698 staining patterns were found in mesenchymal tissue rather than in the migrating cells themselves. This impaired @entity4698 expression may reflect a deficient microenvironment for migration such that neural crest cells cannot colonize properly.

title: Impaired proliferative activity of mesenchymal cells affects the migratory pathway for neural crest cells in the developing gut of mutant XXXX embryos.

entities_list: @entity1963 :: ('MESH:D006627', 'Disease') :: ["Hirschsprung's disease"]

entities_list: @entity4497 :: ('17967(Tax:10090)', 'Gene') :: ['NCAM', 'neural cell adhesion molecule']

entities_list: @entity4698 :: ('18538(Tax:10090)', 'Gene') :: ['proliferative cell-related nuclear antigen', 'PCNA']

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: The oral adsorbent AST-120 is one type of activated @entity505 for oral use. In the present study, AST-120 was administered, to clarify its effect, on surgically induced @entity1578 in @entity235 and @entity35 . Portacaval shunts and varying extents of hepatectomies were performed on 44 @entity235 . Eleven @entity235 were given an ordinary diet (control group), and 33 @entity235 received the oral adsorbent with an ordinary diet after the operation (AST group). Plasma @entity3645 and @entity3265 increased, and body weight decreased in both groups. However, after the administration of AST-120, the plasma @entity3645 and @entity3265 decreased significantly, and the body weight tended to increase in the AST group. Portacaval shunts and about 70 per cent hepatectomy were performed on 59 @entity35 . These @entity35 were divided into two groups, diet with the oral adsorbent (AST group, n = 19) and an ordinary diet alone (control group, n = 40). DNA synthesis and protein synthesis of the liver were measured on the 5th, 10th and 20th postoperative days using radioisotopes in these @entity35 . Both DNA and protein synthesis of the liver were increased significantly in the AST group. Histological examination revealed many more glycogen granules in the cytoplasm of hepatocytes in the AST group compared to the control group on the 5th postoperative day. It was suggested that some metabolic toxin was adsorbed by AST-120 in the alimentary tract.

title: The effect of oral adsorbent on surgically induced XXXX .

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['hepatic failure']

entities_list: @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile acids']

answer: @entity1578 :: (MESH:D017093,Disease) :: ['hepatic failure']


abstract: Introduction. Among all prognostic factors, "margin status" is the only factor under clinician's control. Current guidelines describe histopathologic margin of >5   mm as "clear margin" and 1-5   mm as "close margin." Ambiguous description of positive margin in the published data resulted in comparison of microscopically "involved margin" and "close margin" together with "clear margin" in many publications. Authors attempted to compare the outcome of close and clear margins of stage I and @entity5 to investigate the efficacy of description of margin status. @entity1 and Methods. Historical cohorts of @entity1 treated between January 2010 and December 2011 at tertiary @entity5 hospital were investigated and filtered for stage I and stage II primary @entity957 of @entity1697 . @entity1 with margin status of @entity5 at margin or within 1mm from cut margin were excluded and analyzed in multivariate logistic regression model for locoregional recurrences and Cox regression for overall survival. Results. A total of 104 @entity1 fulfilled the abovementioned criteria, of whom 36 were "clear margin" and 68 were "close margin" with median period of follow-up of 39 months. There was no significant difference in locoregional recurrence (P value: 0.0.810) and survival (P value: 0.0.851) among "close margin" and "clear margin" @entity1 .

title: Close Margins in XXXX : Implication of Close Margin Status in Recurrence and Survival of pT1N0 and pT2N0 @entity5 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage II squamous cell carcinoma of oral cavity', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral cavity']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Oral Cancers']


abstract: OBJECTIVE: In order to search novel nematicidal protease genes, a metagenomic fosmid library was constructed and screened by uncultured method. METHODS: Density gradient centrifugation was used to extract and purify total greenhouse soil microbial DNA. After end-repair, ligation, packing and transformation, metagenomic fosmid library was constructed. At the same time, in order to screen the library, function-driven screening was used as a potential strategy, skim milk was served as substrate and root-knot @entity2199 as targets. RESULTS: The library contained 31,008 clones with the average insert fragment of 36.5 kb, including 1.13 Gbp microbial genetic information, so it was suitable for large-scale microbial functional gene screening. By the function-driven screening, fosmid clone pro12 which contained the nematicidal protease gene was screened. Then, subclones were constructed and screened. A subclone named espro124a5 was screened. After analysis of gene structure, espro124a5 is a secreted extracellular protease and a database search for homologies revealed it possessed 45% identities with peptidase S15 from @entity22359 (accession no. YP_ 756822 at NCBI). It is a novel @entity563 protease. Besides these, it has the @entity563 protease-conserved catalytic triad residues, @entity2574 469, His541 and the catalytic nucleophile Ser348. CONCLUSION: DNA obtained from the method of Nycodenz density gradient centrifugation had high purity, long fragment, and can meet the requirements of constructing metagenomic fosmid library. At the same time, the metagenomic fosmid library contains a lot of microbial genetic information, which is suitable for the screening of the other microbial genetic resources.

title: [Construction of microbial metagenomic library and screening of a nematicidal protease gene in greenhouse cucumber soil infested with root-knot XXXX ].

entities_list: @entity22359 :: ('394221', 'Species') :: ['Maricaulis maris MCS10']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

answer: @entity2199 :: (6239,Species) :: ['nematodes']


abstract: In many Asian countries, @entity2973 and @entity28 @entity1 are sometimes considered healthier than their underweight or normal weight counterparts. Using Taiwan as an example, this research aims to examine the relationship between inappropriate weight and self-rated health (SRH) for adolescents, and inappropriate weight and the parent's impression of their adolescent's general health. We analyzed data from 1,879 adolescents (933 @entity1 and 946 @entity1 ) from the third year (2003) of a panel survey conducted by the Academia Sinica of Taiwan. Adolescents were identified as underweight, normal weight, @entity2973 and @entity28 using body mass index (BMI). Kappa statistic was used to determine agreements between adolescent's own report and their health as reported by their parent. Logistic regression was used to determine odds of reporting reduced health by adolescents with inappropriate weight. A separate regression was carried out using the parent's reports for these adolescents. We found that underweight @entity1 were more likely to report reduced health (OR=2.15, p<0.01). Overweight @entity1 had lower odds of reporting reduced health compared with normal weight @entity1 (OR=0.42, p<0.01). Parents were more likely to report reduced health for underweight @entity1 (OR=2.10, p<0.01). For @entity1 , parents were less likely to report reduced health for @entity2973 @entity1 compared with reports for normal weight subjects (OR=0.51, p<0.01). Being underweight is associated with poor perceived health by both the adolescents and their parents. This contrasts with @entity2973 and @entity28 , which are not. Health educational programs could help in adjusting perceptions concerning the health consequences associated with @entity2973 and @entity28 .

title: Health ratings for underweight, XXXX and @entity28 adolescents: disparities between adolescent's own report and the parent's report.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity2973 :: ('MESH:D050177', 'Disease') :: ['overweight']

answer: @entity2973 :: (MESH:D050177,Disease) :: ['overweight']


abstract: @entity11053 (DADLE) has been reported to exhibit protective effects against @entity519 or @entity63 induced brain insult. However its efficacy on the @entity2759 -reperfusion injury remains unclear. Here we investigate whether DADLE could attenuate @entity63 and reperfusion induced @entity130 in the @entity95 spinal cord. New Zealand white @entity95 were subjected to @entity2759 by infrarenal aortic occlusion for 30min. In the period of @entity2759 , DADLE 0.5mg/kg or NS were infused continuously into the distal clamped abdominal aorta. The heart rate, blood pressure, and core temperature were monitored continuously during the whole experimental procedure. Then the neurological behavioral function was assessed with Tarlov scale system at 1h, 6h, 24h, 48h after reperfusion, and @entity528 evaluation in the ventral horn of gray matter was measured by counting the normal motor neurons at 48h after reperfusion. Comparing with the control group, the Tarlov scores were significantly higher and the incidences of @entity451 were significantly lower in the DADLE group at four time-point recorded. In addition, the normal neurons numbers in the DADLE group were significant more than those in the control group at 48h after reperfusion. These results suggested that DADLE infused into the abdominal aorta during @entity63 period could attenuate @entity146 and the loss of normal motor neuron induced by @entity63 -reperfusion in @entity95 .

title: Protective effect of delta opioid agonist @entity11053 on XXXX reperfusion injury by regional perfusion into abdominal aorta in @entity95 .

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral retardation']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity2759 :: ('MESH:D020760', 'Disease') :: ['spinal cord ischemia']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['paraplegia']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['neural injury']

answer: @entity2759 :: (MESH:D020760,Disease) :: ['spinal cord ischemia']


abstract: OBJECTIVE: To investigate the influence of @entity1961 + @entity3783 + regulatory T cells(Treg cells) on @entity19 @entity356 . METHODS: Treg cell in @entity19 spleen bearing @entity356 was tested in different time points. Magic cell sorting(MACS) method was used to purify @entity19 Treg cells and the Treg cells were injected into @entity19 bearing @entity356 with different dosage. After 3 weeks, the @entity5 size and @entity5 cell apoptosis rate were measured. RESULTS: Treg existed in normal @entity19 spleen with a rate of (3.86+/-0.07)%. In @entity5 model this percentage increased gradually and was (4.12+/-0.13)% after 3 weeks, which was significantly higher than that in control. When Treg cell applied in @entity19 reached 2.0 x 10(5), the @entity5 size enlarged significantly(P=0.013) and @entity5 cell apoptosis rate decreased significantly (P=0.012). CONCLUSIONS: Treg cell is associated with @entity356 progress in @entity19 @entity5 model. Treg cell can promote @entity356 growth and decrease @entity5 apoptosis. The anti- Treg @entity6553 can improve anti- @entity5 effects.

title: [Influence of @entity1961 + and @entity3783 + T regulatory cell on XXXX bearing @entity356 in vivo].

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumor', 'gastric cancer']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: @entity379 ) increases class I major histocompatibility complex (MHC) expression in @entity1 @entity521 cell lines. These cells are of interest because of the initial paucity of MHC expression, a paucity that is also seen in @entity5 and normal brain. The aim of this study was to define further the class I molecules, and to begin to analyze the genetic basis of the regulation. Northern blot analysis with cDNA probes for HLA and @entity2262 ( @entity2262 ) RNAs shows that both are present in reduced quantities (relative to a B-cell control) in control @entity521 cells. The levels of both RNAs are increased following @entity379 . This behavior parallels that of the corresponding polypeptides. Further monoclonal antibody analysis of the class I proteins from IFN-treated cells shows that both @entity1529 and HLA-B are present. For two cell lines, expression of appropriate polymorphic specificities is also shown to be increased. We conclude that @entity379 can cause increased expression of appropriate @entity2149 ,C specificities on cells of neuronal origin. This raises the question of whether these molecules can serve predicted immunological functions.

title: Interferon-mediated induction of class I MHC products in @entity1 neuronal cell lines: analysis of HLA and @entity2262 RNA, and XXXX and HLA-B proteins and polymorphic specificities.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neural tumors']

entities_list: @entity2262 :: ('567', 'Gene') :: ['beta 2-m', 'beta 2-microglobulin']

entities_list: @entity379 :: ('3458', 'Gene') :: ['Gamma-interferon (IFN-gamma', 'IFN-gamma']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma']

answer: @entity1529 :: (3105,Gene) :: ['HLA-A']


abstract: UNASSIGNED: The @entity1 was 77-year-old @entity1 . He visited our hospital with the chief complaint of an abdominal mass in March 2015. We diagnosed the @entity1 with transverse @entity694 and he was suspected of having @entity706 . In March 2016, we attempted to perform right hemicolectomy for the transverse @entity694 , but it was difficult because swollen lymph nodes had formed a large mass with the surrounding tissue, including vessels of the mesentery. We could only complete the surgery after mesenteric lymph node biopsy. On the basis of the results of this biopsy, we diagnosed angioimmunoblastic @entity706 . At first, we administered @entity16980 -COP therapy for @entity706 . However, after 3 courses of this therapy, the @entity1 suddenly developed ileus due to the aforementioned @entity694 . According to enhanced CT performed at the onset of @entity1321 , chemotherapy dramatically reduced the size of the intraperitoneal lymph nodes. We therefore concluded that it was able to treat the @entity694 . We performed right hemicolectomy in June 2015. @entity784 comprises only 2-3% of all @entity706 cases. We experienced a rare case of complications from @entity784 and @entity14 .

title: [A Case of @entity784 Merged with XXXX That We Were Able to Resect after a Chemotherapy Response].

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['Tcell lymphoma', 'malignant lymphoma']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['angioimmunoblastic T-cell lymphoma', 'Angioimmunoblastic T-cell lymphoma']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: OBJECT: Although the effects of Gamma Knife surgery (GKS) on the risk of @entity548 are poorly understood, a certain subset of @entity1 does suffer bleeding after GKS. This study was undertaken to analyze the outcome of @entity1 sustaining @entity548 after GKS; it is the most feared complication of radiosurgical management of @entity7026 ( @entity2758 ). METHODS: Between May 1997 and June 2006, 494 cerebral @entity2758 in 489 @entity1 were treated using a Leksell Gamma Knife Model B, and follow-up evaluations were conducted until June 2007 at the All India Institute of Medical Sciences in New Delhi. Fourteen @entity1 who sustained a @entity548 after GKS formed the study group. In most of these @entity1 conservative management was chosen. RESULTS: The mortality rate was 0% and there was a 7% risk of sustaining a severe @entity51 following rebleeding after GKS. None of the @entity1 sustained rebleeding after complete obliteration. @entity1 with Spetzler-Martin Grade III or less had increased chances of @entity548 after GKS (p < 0.002). The presence of deep venous drainage, @entity439 , @entity101 , or periventricular location on angiography was common in @entity1 with @entity548 after GKS. CONCLUSIONS: The risk of @entity548 that remains following GKS for cerebral @entity2758 is highest in the 1st year after treatment. The present study showed a relatively good outcome even in cases with @entity548 following GKS, with no deaths and minimal morbidity, further substantiating the safety and efficacy of the procedure.

title: Outcome after XXXX following Gamma Knife surgery for @entity7026 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity7026 :: ('MESH:D002538', 'Disease') :: ['cerebral arteriovenous malformations']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['venous hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['deficit']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: Diagnostic ultrasound is a valuable tool for the examination of various anatomical structures in vivo. Improvements in technology have increased its effectiveness and provided a noninvasive method for the in utero observation of a variety of structural and functional events. Ultrasound is utilized in our laboratory to monitor a variety of studies during embryonic and fetal development. Basic to these evaluations is the ability to assess normal growth and development. The cynomolgus, or @entity5434 ( @entity5434 ), has been observed in utero by ultrasound from early gestation to term. The earliest detection of implantation is by the identification of a developing @entity8597 ( @entity8597 ), which may be visualized on gestational day (GD) 14-15. Positive identification of the @entity8597 on GD 16-18 and appearance of the embryo, yolk sac, and cardiac motion on GD 21-25 confirms pregnancy. Once the embryo is evident, measurements of the greatest length (GL) may be used to assess normal growth or to aid in the prediction of gestational age. During the fetal period, a variety of growth parameters aid in fetal evaluation. The gender of the fetus can be accurately identified as early as GD 70-75. An assessment of viability and condition can be determined by the observation of @entity2241 and gross body movement.

title: Characterization of prenatal growth and development in the XXXX ( @entity5434 ) by ultrasound.

entities_list: @entity8597 :: ('MESH:D036821', 'Disease') :: ['gestational sac', 'GS']

entities_list: @entity5434 :: ('9541', 'Species') :: ['Macaca fascicularis', 'crab-eating macaque']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['embryonic and fetal heart rates']

answer: @entity5434 :: (9541,Species) :: ['crab-eating macaque']


abstract: BACKGROUND: In five @entity1 , an apical muscular @entity1757 was closed in a hybrid approach using the Amplatzer   duct occluder during open heart surgery, whereas concomitant defects were treated surgically. In addition to their different @entity299 that needed surgery, all had a muscular @entity1757 in the apex of the heart, poorly accessible for traditional, surgical approach. We describe the method and outcome in these @entity1 . METHODS: The tip of a forceps was advanced from the left into the right ventricle through the @entity1757 . The delivery sheath was caught under visual control in the right ventricle and pulled back into the left ventricle. The disc was developed and pulled back until it was felt tugging at the septum. Then the core was developed. The end of the device was visible in the right ventricle and was secured with a Prolene   suture. RESULTS: The procedures were event-free. During early follow-up there were either no or only insignificant shunts in the region of the prior trabecular defects in four @entity1 . The unsatisfactory result in the last @entity1 was caused by inaccurate preoperative assessment. CONCLUSION: The method seems valuable in @entity1 in need of other intracardiac surgery.

title: A novel method of hybrid intraoperative catheter-based closure of XXXX using the Amplatzer   PDA occluder.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['septal defect', 'ventricular septal defect']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart defects']

answer: @entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defects']


abstract: BACKGROUND: Although @entity9335 have been well described, their incidence in a referral institution had not been studied. OBJECTIVE: The purpose of this study was to evaluate the incidence of @entity9335 , including photocontact @entity1909 , in an academic medical center. METHODS: The results of the assessment of 203 consecutive @entity1 , all of whom had phototests, referred for the evaluation of @entity9335 during a 7.3-year period were reviewed. RESULTS: The mean age was 50 years, and 63% of the @entity1 were @entity1 . The most frequent diagnoses were polymorphous light eruption (26% of the total @entity1 population), @entity9335 (17%), @entity9584 (8%), systemic @entity6337 to therapeutic agents (7%), and solar @entity110 (4%). Positive photopatch reactions, patch test reactions, or both were observed in 40 (29%) of the 138 tested @entity1 . The frequencies of the positive photopatch test reactions were sunscreens (57%), fragrances (18%), and antimicrobial agents (13%). Of the positive patch test responses, fragrances elicited 47% of the total positive reactions, followed by sunscreens (39%) and antimicrobial agents (7%). CONCLUSION: Polymorphous light eruption, @entity9335 , and @entity9584 were the most frequently made diagnoses. Sunscreens, fragrances, and antimicrobial agents were the most common clinically relevant photoallergens and allergens.

title: Results of evaluation of 203 XXXX for photosensitivity in a 7.3-year period.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity6337 :: ('MESH:D017484', 'Disease') :: ['phototoxicity']

entities_list: @entity9584 :: ('MESH:D017454', 'Disease') :: ['photoallergic contact dermatitis']

entities_list: @entity9335 :: ('MESH:D010787', 'Disease') :: ['chronic actinic dermatitis', 'photosensitivity disorders']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

entities_list: @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Very little is known about the genetics of @entity1492 ( @entity1492 ) of bone. We applied array comparative genomic hybridization (CGH) to identify genes and genomic regions with potential role in the pathogenesis of this @entity5 . Seventeen @entity1 with @entity1492 of bone were included in the study. Array CGH analysis was carried out in 13 fresh frozen tissue specimens from 11 of these @entity1 (nine primary @entity5 and four local recurrences). DNA was extracted and hybridizations were performed on Agilent 244K CGH oligoarrays. The data were analyzed using Agilent DNA Analytics Software. The number of changes per @entity1 ranged from 0 to 132 (average = 43). Losses were most commonly detected at 6q, 8p, 9p, 10, 13q, and 20p. @entity986 was homozygously deleted in 7/11 @entity1 . Hypermethylation of both @entity986 ( @entity986 ) and @entity986 (ARF) was found in 1/14 @entity1 . An internal deletion of @entity24866 was found in a region with common losses at 13q13.1. The most frequent gains were seen at 1q, 4q, 5p, 8q, 12p, 15q, 16q, 17q, 20q, 22q, and Xp. Single recurrent high level amplification was detected at 4q12, including @entity2467 , @entity675 , and @entity319 . No activating mutations were found in any of them. Immunohistochemistry revealed expression of @entity675 and/or @entity3820 in 12/17 samples. Moreover, small regions of gains pinpointed genes of particular interest, such as @entity2856 at 15q26.3 and @entity6599 at 1q21.1. In conclusion, our analysis provided novel findings that can be exploited when searching for markers for diagnosis and prognosis, and targets of therapy in this @entity5 type.

title: Frequent deletion of XXXX and recurrent coamplification of @entity2467 , @entity675 , and @entity319 in @entity1492 of bone--an array comparative genomic hybridization study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1492 :: ('MESH:D005354', 'Disease') :: ['FS', 'fibrosarcoma']

answer: @entity986 :: (1029,Gene) :: ['CDKN2A']


abstract: PURPOSE: To compare @entity463 and brain @entity3 using T1-weighted dynamic contrast-enhanced (DCE)-MRI perfusion technique. METHODS: 26 @entity1 with @entity463 and 32 @entity1 with metastatic @entity75 with no treatment who underwent DCE-MRI were, retrospectively, analyzed. DCE perfusion parameters K(trans) and Vp were calculated for the whole @entity5 . Signal intensity time curves were quantified by calculating the area under the curve (AUC) and the logarithmic slope of the washout phase to explore the heterogeneous @entity5 characteristics. RESULTS: @entity463 did not differ from all brain @entity3 in K(trans) (P = .34) or Vp (P = .47). @entity463 and @entity320 @entity3 differed from hypovascular @entity3 in AUC and log slope of the washout phase of the signal intensity time curve (P < .05); however, @entity463 and @entity320 @entity3 did not differ from each other (AUC: P = .78, Log slope: P = .77). @entity463 and @entity320 @entity3 differed from hypovascular @entity3 in the ratio of Voxelneg /Voxelpos (P< .03); however, they did not differ from each other. @entity463 and @entity320 @entity3 differed from each other in Voxelneg_threshold at higher negative log slope threshold. CONCLUSION: DCE-MRI showed that it has a potential to differentiate @entity463 , @entity320 @entity3 and hypovascular @entity1313 . Logarithmic slope of the washout phase and AUC of the signal intensity time curve were shown to be the best discriminator between @entity5 .

title: XXXX and Brain Metastases using Dynamic Contrast-Enhanced Perfusion MRI.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hypervascular and hypovascular neoplasms']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'glioblastoma', 'Glioblastoma']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity463 :: (MESH:D005909,Disease) :: ['Comparison of Glioblastomas']


abstract: @entity302 affects approximately 1% of the world's population. Genetic factors and acquired etiologies, as well as a range of environmental triggers, together contribute to epileptogenesis. We have identified a family with three daughters affected with progressive @entity3148 with @entity2055 . Clinical details of the onset and progression of the neurologic presentation, @entity302 , and the natural history of progression over a 10-year period are described. Using autozygosity genetic mapping, we identified a high likelihood homozygous region on chromosome 7p12.1-7q11.22. We subsequently applied whole-exome sequencing and employed a rare variant prioritization analysis within the homozygous region. We identified @entity13951 in the @entity972 channel tetramerization domain-containing seven gene, @entity13952 , which is expressed predominantly in the brain. Mutations in this gene have been implicated previously in @entity302 phenotypes due to disturbances in @entity972 channel conductance. Pathogenicity of the mutation was supported by bioinformatic predictive analyses and variant cosegregation within the family. Further biologic validation is necessary to fully characterize the pathogenic mechanisms that explain the phenotypic causes of @entity302 with @entity2055 in these @entity1 .

title: Linkage analysis and exome sequencing identify a novel mutation in @entity13952 in @entity1 with progressive XXXX with @entity2055 .

entities_list: @entity3148 :: ('MESH:D004831', 'Disease') :: ['myoclonus epilepsy']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizures', 'epileptic', 'epilepsy', 'Epilepsy']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity13951 :: ('p|SUB|Y|276|C', 'ProteinMutation') :: ['p.Tyr276Cys']

answer: @entity3148 :: (MESH:D004831,Disease) :: ['myoclonus epilepsy']


abstract: UNASSIGNED: e13021 Background: @entity1822 are @entity146 associated with a poor prognosis. Recurrence rates range from 53-71% even when early diagnosis is made. Furthermore, adjuvant chemotherapy with @entity632 or @entity1205 / @entity136 has shown response rates of 27-36%. Thus, there is a strong need for novel agents in the treatment of @entity1822 . METHODS: @entity1 and ECC-1 cell lines were cultured in RPMI 1640 and MEM Alpha medium with 10% @entity2241 ( @entity2241 ). Pure Flavokawain B (FKB) was obtained from LKT laboratories (St. Paul, MN). Cell lines were grown to confluence and treated with 8.8, 4.4, 2.2, and 1.1   M of FKB. The IC50 was determined for each cell line using XTT assay. Fluorescence-activated cell sorting (FACS) analysis of apoptosis and cell cycle analysis were performed for FKB treated cell lines. Lastly, real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western Blot analysis were performed to evaluate differences in the expression of apoptotic markers in treated and non-treated cell lines. Statistical analysis was performed using student's t test. RESULTS: Both SK-LMS-1 and ECC-1 were sensitive to FKB treatment, while control endometrial fibroblasts were resistant. FKB treatment resulted in an increase in both early and late apoptosis in @entity1 and ECC-1 cell lines relative to control ( @entity19    3.1%; 29.1    1.3%; p<0.01). Cell cycle assays illustrated an increase in the G2-M fraction in treated @entity1 and ECC-1 cell lines relative to control (34.3    4.9%; 22.1    3.5%; p<0.01). RT-PCR showed a dose dependent up-regulation of @entity3049 ( @entity3049 ), Bim and @entity589 , and down regulation of @entity1836 and survivin consistent with the pro-apoptotic effects of FKB, confirmed by western blot. CONCLUSIONS: FKB appears to induce apoptosis in @entity1 and ECC-1 cell lines via increased expression of @entity3049 , Bim and @entity589 , leading to activation of the death receptor pathway, and down regulation of @entity1836 and survivin. FKB may be a novel, naturally occurring compound effective in the treatment of @entity1822 .

title: Mechanisms of apoptosis induction by flavokawain B in a XXXX cell line.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['Doxorubicin']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive tumors']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['Docetaxel']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['uterine leiomyosarcoma', 'leiomyosarcoma', 'Leiomyosarcomas']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['Gemcitabine']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['FBS', 'fetal bovine serum']

answer: @entity1822 :: (MESH:D007890,Disease) :: ['uterine leiomyosarcoma']


abstract: A 75 year-old @entity1 was admitted with a left @entity1158 resulting from an @entity1188 in the right middle artery's territory. Her manual preference was ambiguous from early childhood. She presented with severe bilateral @entity1742 , autotopoagnosia, finger @entity1054 , and left @entity1057 . There was, however, no @entity2026 nor @entity1055 . When the @entity1 attempted to perform gestures on order, she compulsively produced oral or written language. In this very unusual case, dominance for gesture and dominance for language were strictly independent, each ensured by one hemisphere. The @entity1 's performances in gestual activities, especially dissociation between automatic and @entity717 , and compulsive linguistic productions, are discussed in relation to this functional lateralization. We suggest that the propositional nature of the responses required in test conditions could activate either @entity3180 in the left cerebral hemisphere, or @entity1742 in the right. A competition between the two hemispheres could explain the @entity1 's linguistic apraxic or behavior in response to orders. Autotopoagnosia, an uncommon symptom, could interfere with @entity1742 , but is not directly responsible.

title: [ XXXX and autotopoagnosia without @entity2026 or @entity1055 with compulsive language activity in right hemispheric lesion].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity3180 :: ('MESH:D007806', 'Disease') :: ['voluntary language']

entities_list: @entity1057 :: ('MESH:D058069', 'Disease') :: ['spatial neglect']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['voluntary movements']

entities_list: @entity1742 :: ('MESH:D001072', 'Disease') :: ['apraxia', 'voluntary gestures']

answer: @entity1742 :: (MESH:D001072,Disease) :: ['Apraxia']


abstract: Advanced @entity43 continues to be a difficult @entity5 to evaluate noninvasively. Recent developments in chemotherapy have enhanced response rates in this disease, thus improving the likelihood of @entity5 regression. Computed Tomography (CT) allows the noninvasive estimation of @entity5 extent in @entity1 with @entity43 . Seventeen @entity1 with @entity43 had 22 whole body CT scans performed either just prior to or following laparotomy. For determination of @entity5 involvement, when the CT was positive, a high pathologic correlation was found at liver, ascitic, peritoneal, mesenteric, and omental sites (sensitivity). When the cT was negative, high pathologic correlation was found at ascitic and mesenteric sites (specificity). Lower and negative correlation at other disease sites is attributed to difficulty of CT detection of small (1 cm) @entity5 nodules on visceral surfaces. Eighteen @entity1 with advanced @entity43 were followed prospectively during treatment with repetitive CT scans. CT results were compared with physical examination, other radiologic studies, and clinical status. In 83% (15/18) of @entity1 and 88% (59/67) of CT scans performed, CT was found to contribute useful management information. Clinical decisions were made on the basis of CT alone in 43% (29/67) of scans performed. These data suggest that CT scanning is very useful in the staging and follow-up of @entity1 with @entity43 and can replace other radiologic procedures, but it is not completely accurate and needs to be correlated with physical examination and in cases without @entity5 visible with CT, with laparotomy.

title: Use of the computed tomographic whole body scanner to stage and follow @entity1 with advanced XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'epithelial ovarian carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian carcinoma']


abstract: BACKGROUND: The impact of long-term preoperative @entity413 control on short-term surgical complications is unclear. We investigated whether preoperative hemoglobin A1c (HA(1c)) levels correlated with the risk of @entity260 . METHODS: A database of 38,989 @entity1 undergoing major surgical procedures from October 1996 to May 2007 was reviewed. Of these @entity1 , 2,960 were diagnosed @entity6 with a HA(1c) level within 30 days before their operation. National Surgical Quality Improvement Program (NSQIP) definitions were used in determining @entity260 . RESULTS: Of 36,039 @entity7964 @entity1 , 5,095 experienced 1 or more complications (14.1%). In 2,960 @entity6 @entity1 , 780 @entity6 @entity1 had 1 or more complications (26.4%) (P <or=.001). Mortality was higher in @entity6 than nondiabetics (4.2% vs 1%, respectively; P <.0001). There was no correlation between HA(1c) levels and risk of @entity532 , or @entity204 . CONCLUSIONS: Although our data show an increased risk of surgical complications in @entity6 , there was no detectable correlation between risk of complication and HA(1c) level. This suggests that poor long-term @entity413 control may not play a major role in determining short-term surgical morbidity.

title: Long-term XXXX control and risk of perioperative complications.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['complication, type of complication']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity7964 :: ('OMIM:612551', 'Disease') :: ['nondiabetic']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: The relationship between the early cellular response to embryo implantation and subsequent embryo survival was explored. Immunohistochemistry using the anti- @entity3804 antibody ( @entity3804 ) was used to localize and quantify maternal inflammatory cells present at the fetoplacental interface. @entity3804 is expressed mostly on macrophages, but is also present on natural killer (NK) cells, neutrophils, and B cells. The occurrence of @entity3804 -positive cells at the fetoplacental interface was quantified in CBA/J females mated by DBA/2 males (20-30% @entity2085 ) and CBA/J females mated by BALB/c males (5-10% @entity2085 ) in order to investigate the relationship between infiltration by these types of cells and subsequent @entity2085 . @entity3804 -positive cells were found to infiltrate decidua of each embryo starting at Day 6 of gestation. Their numbers sharply increased on Days 7 and 8, to a plateau on Days 8 to 10, well before any damage to the embryo is macroscopically visible on Days 10 to 12 of gestation. The resorption-prone mating of CBA/J female by DBA/2 male showed a significantly elevated number of @entity3804 -positive cells in 26% of the embryos on the eighth day of gestation compared to CBA/J female by BALB/c male matings which were taken as the reference mating. Moreover, experimental conditions modulating fetal survival in CBA/J mothers such as poly (I:C) treatment of DBA/2-mated females (lower survival) or mating with BALB/c males (higher survival than with the mating with DBA/2 males), were found to be associated with high or low numbers numbers of @entity3804 -positive cells at the fetoplacental interface. Furthermore, injection of anti- @entity3804 into pregnant @entity19 at Day 6 of gestation significantly reduced the subsequent incidence of resorption in the resorption prone CBA/J x DBA/2 mating. These results suggest that @entity3804 -positive cells are associated with the etiology of @entity2208 in this system.

title: Relationship between decidual leukocyte infiltration and XXXX in a @entity19 model of early fetal resorption.

entities_list: @entity2085 :: ('MESH:D020964', 'Disease') :: ['embryo loss']

entities_list: @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion']

answer: @entity2208 :: (MESH:D000022,Disease) :: ['spontaneous abortion']


abstract: The @entity5441 ( @entity5441 ) comprises a heterogenous group of disorders characterized by marked blood @entity1712 with @entity1712 -associated organ damage. Eight @entity1 with a median age at diagnosis of 42 years (range 19-67) received @entity2213 (IM) for @entity18053 - @entity675 -negative @entity5441 resistant to previous conventional treatment. Median number of prior therapies was 3 (range 2-4). Median time from diagnosis to IM initiation was 112 months (range 2-293). Four @entity1 were treated daily with 100 mg IM, whereas the remaining four @entity1 were treated daily with 400 mg IM. Four male @entity1 (50%) achieved @entity1939 ( @entity1939 ) after median of 7 days (range 3-150) using 100 mg daily IM (n = 2) and 400 mg (n = 2). Median duration of IM treatment for IM responders was 18 months (range 2-88). No adverse events were reported throughout the treatment duration. Two @entity1 maintained @entity1939 while on 100 mg weekly IM. Four @entity1 (2 @entity1 and 2 @entity1 ) failed IM treatment. Median duration of IM for non-responding @entity1 was 3 weeks (range 3-12). Non-responding @entity5441 @entity1 were significantly older and had lower percentage of blood @entity1712 when compared with IM responders. Our results suggest that IM, even at lower than conventional doses, may induce and maintain long-term remission for @entity18053 - @entity675 -negative @entity5441 .

title: @entity2213 may induce long-term clinical response in @entity18053 - XXXX -negative @entity5441 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity5441 :: ('MESH:D017681', 'Disease') :: ['HES', 'idiopathic hypereosinophilic syndrome']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['complete haematologic response', 'CHR']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib mesylate']

answer: @entity675 :: (5156,Gene) :: ['PDGFRa']


abstract: Fibronectin @entity8 ( @entity8946 ) is a newly recognized @entity8 that results in @entity633 , microscopic @entity811 , @entity101 , @entity8 , and @entity454 in the 2d to 6th decade of life. The disease is characterized histologically by massive deposits of fibronectin (Fn) present in the subendothelial spaces of @entity8 . The cause of @entity1 @entity8946 is unknown. In order to localize a candidate gene for @entity8946 , we performed linkage analysis of a large, 193-member pedigree containing 13 affected individuals. Since we had previously excluded the genes for Fn and uteroglobin as candidate genes for @entity8946 , a total-genome search for linkage was performed. Examination of 306 microsatellite markers resulted in a maximum two-point LOD score of 4.17 at a recombination fraction of. 00 for marker D1S249, and a maximum multipoint LOD score of 4.41 for neighboring marker D1S2782. By detection of recombination events, a critical genetic interval of 4.1 cM was identified, which was flanked by markers D1S2872 and D1S2891. These findings confirm that @entity8946 is a distinct disease entity among the fibrillary glomerulopathies. Gene identification will provide insights into the molecular interactions of Fn in @entity8946 , as well as in genetically unaltered conditions.

title: The gene for XXXX fibronectin @entity8 maps to 1q32, in the region of the regulation of complement activation gene cluster.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal glomerular capillaries', 'glomerulopathy', 'renal tubular acidosis type IV', 'autosomal dominant disease of the kidney']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Six cases of @entity2926 with @entity358 are reported. Three cases were accompanying an hepato- @entity1310 due to L. icterohaemorrhagiae. The first @entity1 died with massive hemoptysis. The second, presenting a @entity9757 predominant on the left side, recovered after plasma exchange and hemofiltration. The third case concerned a @entity3126 complicating a vascular refilling in a @entity1457 it simply recovered. The three other cases were observed in an @entity2926 : in two cases, L. Australis was responsible; in the last, L. icterohaemorrhagiae was involved. The first @entity1 had a radiologic picture simulating @entity9758 . The second had @entity3126 complicating a vascular refilling in a @entity1457 . The last was an acute @entity649 , treated with artificial ventilation with @entity114 therapy and corticotherapy. All these 3 @entity1 recovered. The diagnostic, physiopathologic and therapeutic problems of these @entity358 of @entity2926 are discussed. The lesional nature of the @entity3126 is proved by the low pulmonary wedge pressures observed with the Swan-Ganz Catheter.

title: [Respiratory complications of XXXX . Apropos of 6 cases, 3 of which show hemodynamic studies].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis']

entities_list: @entity2926 :: ('MESH:D007922', 'Disease') :: ['leptospirosis', 'anicteric leptospirosis']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema']

entities_list: @entity9757 :: ('MESH:C535590', 'Disease') :: ['bilateral pneumopathy']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['shock syndrome']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity9758 :: ('MESH:D014391', 'Disease') :: ['miliary tuberculosis']

answer: @entity2926 :: (MESH:D007922,Disease) :: ['leptospirosis']


abstract: Among traditional cardiovascular risk factors, apolipoprotein (apo)B/ @entity1675 ratio is considered to have the strongest predictive value for @entity385 . Nevertheless, there are imsufficient data to support this ratio as an independent risk predictor of @entity385 in elderly individuals. In this case-control study, we evaluated @entity755 / @entity1675 ratio as a predictor of @entity385 in a cohort of elderly subjects. A total of 163 @entity1 aged>70 years (88 @entity1 ) admitted due to a first-ever @entity64 and 166 volunteers (87 @entity1 ) with no history of @entity65 were included. The association between @entity755 / @entity1675 ratio and @entity64 was determined by multivariate logistic regression modeling after adjusting for potential confounding factors, including lipid parameters. @entity64 @entity1 exhibited a higher @entity755 / @entity1675 ratio than controls (1.04  0.33 vs 0.86  0.22; P<.001). In univariate analysis, crude odds ratio (OR) for @entity755 / @entity1675 ratio was 1.27 per 0.1 increase (95% confidence interval [CI]=1.15-1.39; P<.001). Compared with subjects with an @entity755 / @entity1675 ratio in the lowest quartile, those within the highest quartile had a 6.3-fold increase in the odds of suffering an @entity385 (95% CI=3.17-12.48; P<.001). This association remained significant after controlling for potential confounders, including sex, age, smoking status, body mass index, waist circumference, @entity413 and @entity2690 levels, the presence of @entity101 and @entity6 , and lipid profile parameters (adjusted OR=3.02; 95% CI=1.16-7.83; P=.02). Our findings support elevated @entity755 / @entity1675 ratio as an independent predictor of @entity385 in individuals over age 70.

title: @entity755 -to-A1 ratio as a predictor of XXXX in elderly subjects.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['acute ischemic/nonembolic stroke', 'stroke', 'Stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['acute ischemic nonembolic stroke']


abstract: Tick collection on one side of the body and whole tail was performed weekly over one year on 11 Gambian N'Dama ( @entity291 ) and 11 Gobra @entity7040 ( @entity7040 ) @entity291 to assess breed susceptibility to naturally occurring ticks. Enzyme-linked immunosorbant assay was also performed to assess the serological prevalence of Anaplasma marginale antigen and Babesia bigemina antibody. Packed red cell volume was measured and liveweight gain was recorded. Significantly higher numbers of Amblyomma variegatum (P < 0.002) and Hyalomma spp. (P < 0.001) were found on Gobra @entity7040 than on N'Dama @entity291 . The serological prevalence of A. marginale antigen was significantly (P < 0.001) lower in N'Dama breed, whilst no difference in the serological prevalence of B. bigemina antibody was found between N'Dama and Gobra @entity291 . Packed red cell volume was negatively affected by A. @entity281 in both breeds, but to a lesser extent in N'Dama @entity291 . Liveweight gain was significantly (P < 0.003) higher in N'Dama in comparison with Gobra @entity291 during the period of abundance of A. variegatum and Hyalomma spp. adults. The significantly lower burdens of A. variegatum and Hyalomma spp. ticks in Gambian N'Dama in comparison with Gobra @entity7040 confirms previous findings. It also shows a more deleterious effect of ticks and @entity7545 on animal production and health in Gobra @entity7040 than in N'Dama @entity291 . The presence of a tick resistant trait in N'Dama @entity291 is suggested.

title: Susceptibility to different tick genera in Gambian N'Dama and Gobra XXXX exposed to naturally occurring tick infestations.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['marginale infection']

entities_list: @entity291 :: ('9913', 'Species') :: ['cattle', 'Bos taurus']

entities_list: @entity7040 :: ('9915', 'Species') :: ['zebu', 'zebu cattle', 'Bos indicus']

entities_list: @entity7545 :: ('MESH:D017282', 'Disease') :: ['tick-borne diseases']

answer: @entity7040 :: (9915,Species) :: ['zebu cattle']


abstract: AIMS: Adjunctive therapy with glycoprotein IIb/IIIa inhibitors has been shown to reduce @entity532 and improve clinical outcome in @entity1 with primary percutaneous coronary intervention (PCI) for @entity583 . Little is known about the use of eptifibatide in this setting. METHODS AND RESULTS: One hundred and two @entity1 with ST elevation @entity583 <12 h scheduled for primary percutaneous intervention were randomly assigned to early eptifibatide given in the emergency room (early) or optional eptifibatide at the time of PCI (late or no). Primary endpoint was the patency of the @entity1188 vessel before PCI. @entity1 in the early group received their first eptifibatide bolus, a mean of 45 min before angiography. TIMI 3 patency before PCI was observed in 34% in the early group and 10% in late or no group (P=0.01). The incidence of complete ST resolution 1 h after PCI was 61% in early group and 66% in the late or no group, respectively (P=n.s.). There were no significant differences in the rates of TIMI 3 flow after PCI, death, reinfarction, @entity64 , and major @entity548 complications until day 30. CONCLUSION: In this pilot trial, double bolus eptifibatide given in the emergency room improved TIMI 3 grade flow of the @entity1188 -related coronary artery before PCI. These results should be confirmed in a larger trial and whether this advantage translates into an improvement in clinical outcome should be tested in a trial with primary clinical endpoints.

title: Early eptifibatide improves TIMI 3 patency before primary percutaneous coronary intervention for XXXX : results of the randomized integrilin in acute @entity583 (INTAMI) pilot trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['ischaemic complications']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute ST elevation myocardial infarction', 'myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute ST elevation myocardial infarction']


abstract: In vitro cultured B16 @entity320 cells, which were previously found to have an impaired expression of H-2Kb and Db (as evaluated by antisera absorption assay), were used to study growth and @entity3 in allogeneic @entity19 in relation to H-2 expression. The possible emergence of somatic hybrids with host cells was also examined. @entity19 cells grown subcutaneously in allogeneic BALB/c @entity19 (H-2d) did not show a lack of H-2b expression, nor the acquirement of H-2d antigens was found. Spontaneous lung metastases were found in about 30% of BALB/c @entity19 with progressing B16 @entity5 . Single lung metastases showed higher H-2b levels than cells from the respective @entity5 , and did not express host H-2 antigens. @entity5 take was concomitant to the rise of an anti-H-2b humoral response: disease outcome was independent from the serum titer. @entity19 cells injected intravenously in BALB/c @entity19 gave rise to lung colonies; different colonies showed a wide range of H-2b antigens levels and no H-2d expression. Lung colonization capacity in normal allogeneic BALB/c @entity19 was significantly higher than in syngeneic C57BL/6 @entity19 . Both syngeneic and allogeneic @entity19 , when pretreated with @entity786 (CY) to reduce natural killer cell activity, showed a significant increase in lung colonization by @entity19 cells. CY-treated C57BL/6 @entity19 showed significantly higher numbers of lung colonies than CY-treated BALB/c @entity19 . In conclusion, B16 growth and @entity3 in the allogeneic environment do not seem to be determined by a selection of H-2-negative variants or by the emergence of somatic hybrids with host cells.

title: Growth and XXXX in allogeneic hosts. Lack of H-2-negative or somatic hybrid variant selection.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: 320-row CT enables dynamic CT angiography (4D CTA) of the entire intracranial circulation and whole-brain perfusion imaging ( @entity93 ). Sixty acute @entity1 with @entity16 underwent various 320-row CT-specific protocols, including combined 4D CTA and @entity93 . Clinical and neuroradiological records were assessed for presumptive diagnoses, final diagnoses, supplementary and follow-up imaging studies. Additional diagnostic benefits delivered by 320-row CT were noted. Out of 60 procedures, 59 were accomplished successfully. @entity63 (n = 19), @entity1779 (n = 7) and transient @entity63 attacks (n = 10) were the major final diagnoses. Except one small cortical and two small subcortical @entity1188 all @entity63 were diagnosed. All @entity548 were diagnosed together with their underlying vascular pathology in five atypical cases. In conclusion, 320-row CT is a technically robust procedure being suitable for comprehensive neuroimaging of acute @entity1 . It can provide dynamic angiographic and perfusion data of the whole brain and can deliver additional diagnostic information not available by standard CT.

title: Neuroimaging by 320-row CT: is there a diagnostic benefit or is it just another scanner? A retrospective evaluation of 60 consecutive acute neurological XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemias', 'ischemic']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A cross-sectional pilot study was conducted in Chiang Mai, Thailand, to determine the prevalence of @entity5746 and @entity526 in @entity1707 , broiler @entity1573 and @entity1 workers from farms and abattoirs in northern Thailand, and compare their antimicrobial resistance profiles. Fecal samples and cloacal swabs were collected from 150 @entity1707 and 150 @entity1573 at the farm. Fecal samples from @entity1707 , cloacal swabs from @entity1573 , and carcass swabs from both animals were collected from 100 @entity1707 and 100 @entity1573 at the abattoir. Stool samples were collected from 15 @entity1707 farm workers and seven @entity1573 farm workers. Primary isolation and identification of @entity5746 and @entity526 were conducted using standard methods. In vitro susceptibility testing of @entity5746 and @entity526 was conducted using the broth microdilution method, based on the United States National Committee for Clinical Laboratory Standards (NCCLS) guidelines. The prevalence of @entity5746 from @entity1707 and @entity1573 samples ranged from 2% to 25%. The prevalence of @entity526 in @entity1573 and @entity1707 ranged from 36.8% to 47.6%. In @entity1 , the prevalence of @entity5746 was 15%, and the prevalence of @entity526 ranged from 51% to 53%. Resistance in @entity5746 was found for @entity803 (84.7%), @entity802 (27.1%), @entity21562 (18.6%), @entity869 (13.6%), and ceftiofur (3.4%), and in @entity526 for @entity803 (91.5%), @entity802 (67.4%), @entity869 (61.6%), @entity21562 (51.8%), @entity14116 (28.7%), @entity2177 (12.5%), @entity21563 (4.9%) and @entity2756 (1.5%).

title: Prevalence of @entity5746 and XXXX , and their resistance to antimicrobial agents, in farming communities in northern Thailand.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'humans']

entities_list: @entity21563 :: ('MESH:C053503', 'Chemical') :: ['ceftiofur']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity14116 :: ('MESH:C052904', 'Chemical') :: ['enrofloxacin']

entities_list: @entity21562 :: ('MESH:C035534', 'Chemical') :: ['florfenicol']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken']

entities_list: @entity802 :: ('MESH:D009268', 'Chemical') :: ['nalidixic acid']

entities_list: @entity5746 :: ('MESH:D012480', 'Disease') :: ['Salmonella']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity526 :: (562,Species) :: ['E. coli']


abstract: OBJECTIVE: To describe surgical repair of a complete @entity4007 ( @entity4007 ) in a @entity235 . STUDY DESIGN: Clinical report. ANIMAL: A 5-month-old, 9.2 kg male Shetland sheepdog. METHODS: Echocardiographic examination revealed an ostium primum @entity118 ( @entity118 ), an inlet @entity1757 ( @entity1757 ), @entity339 ( @entity339 ) and @entity997 ( @entity997 ), and a complete @entity4007 was diagnosed. Surgical correction was performed using cardiopulmonary bypass (CPB) via right atriotomy. A @entity736 ( @entity736 ) patch was secured along the margin of the inlet @entity1757 using simple continuous suture, then the cleft in the septal mitral leaflet was sutured. Similarly, the cleft in the septal tricuspid leaflets was sutured. To complete inlet @entity1757 closure, the @entity1757 patch was secured to these sutured leaflets by simple continuous suture. Another PTFE patch was used to close the ostium primum @entity118 . RESULT: After surgery, @entity339 , @entity997 , and interventricular shunting were decreased. The @entity235 was alive 6 years and 5 months after the surgery with no evidence of an interventricular shunt, @entity997 , or other clinical signs. CONCLUSIONS: Complete @entity4007 in a @entity235 was corrected using a 2-patch technique under CPB.

title: Surgical repair of a complete XXXX in a @entity235 .

entities_list: @entity736 :: ('CHEBI:53251', 'Chemical') :: ['PTFE', 'polytetrafluoroethylene']

entities_list: @entity4007 :: ('MESH:D004694', 'Disease') :: ['endocardial cushion defect', 'ECD']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral regurgitation', 'MR']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['VSD', 'ventricular septal defect']

entities_list: @entity997 :: ('MESH:D014262', 'Disease') :: ['TR', 'tricuspid regurgitation']

entities_list: @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defect', 'ASD']

answer: @entity4007 :: (MESH:D004694,Disease) :: ['endocardial cushion defect']


abstract: OBJECTIVES: The objectives of this 5-year retrospective investigation were threefold. (1) Among @entity1 with @entity1909 of the feet consistent with @entity3408 ( @entity3408 ), what were the final diagnoses of those with @entity1909 only on the feet and those whose foot @entity1909 was accompanied by other cutaneous involvement? (2) Among those @entity1 determined to have @entity3408 , what were the relevant allergens? (3) Have the allergens in shoes in the United States changed as a consequence of modifications in footwear manufacture and style design? METHODS: Of 704 @entity1 patch-tested at the University of Kansas Medical Center with the North American @entity5526 Group's standard allergen tray and/or the University of Kansas "shoe and rubber" tray, 70 @entity1 presented with a clinical pattern suggestive of @entity3408 of the foot. RESULTS: Compared with those without foot @entity1909 , these @entity1 were more likely to be atopic and male with bimodal age distribution: <19 and 41 to 60 years. Despite clinical evidence suggesting @entity566 , only 23 (32.9%) @entity1 had @entity3408 to components of shoes, whereas 30 (42.9%) had @entity1569 . Among the remaining @entity1 , 4 (5.7%) had a non-shoe @entity566 , 3 (4.3%) had dyshidrosis, 2 (2.9%) had @entity1909 , 2 (2.9%) had @entity14654 , and 1 (1.4%) each had @entity21361 , @entity272 , @entity402 , id reaction, and traumatic/frictional @entity1909 as their primary diagnosis. One @entity1 had not received a diagnosis when last seen. CONCLUSIONS: When evaluated by sites of involvement, @entity1569 was diagnosed as often as @entity3408 to shoes when the @entity1909 was confined to the foot but was more frequent than @entity3408 when both the hands and feet were involved. With respect to @entity1909 , @entity2483 were the principal allergens, followed by chromated leather and adhesives. Iatrogenic @entity3408 was also common, and among all allergens, @entity3637 caused the most frequently observed relevant reaction.

title: The etiology of allergic-appearing foot XXXX : a 5-year retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3408 :: ('MESH:D017449', 'Disease') :: ['ACD', 'allergic contact dermatitis']

entities_list: @entity14654 :: ('MESH:D014008', 'Disease') :: ['tinea pedis']

entities_list: @entity21361 :: ('MESH:D010916', 'Disease') :: ['pityriasis rubra pilaris']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity3637 :: ('MESH:D001414', 'Chemical') :: ['bacitracin']

entities_list: @entity5526 :: ('MESH:D003877', 'Disease') :: ['Contact Dermatitis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['juvenile plantar dermatosis']

entities_list: @entity2483 :: ('MESH:C566443', 'Disease') :: ['rubber components']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['shoe dermatitis', 'nummular dermatitis', 'dermatitis']

answer: @entity1909 :: (MESH:D003872,Disease) :: ['dermatitis']


abstract: When @entity1 develop @entity810 , a small fraction of them will develop @entity454 later. The severity of @entity8 in the remaining @entity1 is uncertain because studies have not carefully examined renal function over time or the precise timing of entry into a late stage of @entity740 . To determine these factors, we used a United States Department of Veterans Affairs database to ascertain long-term renal function in 113,272 @entity1 . Of these, 44,377 had established @entity740 and were analyzed separately. A cohort of 63,491 @entity1 was hospitalized for @entity583 or @entity55 and designated as controls. The remaining 5,404 @entity1 had diagnostic codes indicating @entity810 or @entity4295 . Serum @entity1011 , estimated glomerular filtration rates, and dates of @entity204 over a 75-month period were followed. Renal function deteriorated over time in all groups, but with significantly greater severity in those who had @entity810 and @entity4295 compared to controls. @entity1 with @entity810 , especially those with @entity4295 , were more likely than controls to enter stage 4 @entity740 , but this entry time was similar to that of @entity1 who initially had @entity740 . The risk of @entity204 was elevated in those with @entity8 compared to controls after accounting for covariates. We found that @entity1 who had an episode of @entity4295 were at high risk for the development of stage 4 disease and had a reduced survival time when compared to control @entity1 .

title: Outcomes following diagnosis of XXXX in U.S. veterans: focus on @entity4295 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['acute kidney injury and chronic kidney disease', 'renal impairment']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity4295 :: ('MESH:D007683', 'Disease') :: ['acute tubular necrosis']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury', 'acute renal failure']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity810 :: (MESH:D058186,Disease) :: ['acute renal failure']


abstract: The homotransplanted heart is in severe failure in the immediate post-operative period, secondary to @entity63 inherent to the technic of orthotopic transplantation. The present work was carried out to investigate if @entity2224 followed by cold coronary perfusion could protect the homograft during implantation by evaluating the post-operative cardiac performance. In the control group, 7 hearts were excised, immediately immersed in physiological saline at 5 degrees C, and homotransplanted. In a second group of 4 grafts, @entity2224 was induced and the coronary bed was perfused immediately with cold (5 degrees C) extracellular solution for a period of 10 minutes before orthotopic implantation. All animals were prepared at the end of surgery for hemodynamic studies to be carried out 3, 24 and 48 hours post-operatively in the resting state. In group I, the myocardial temperature dropped to 13.5 degrees C in 14.5 minutes. In group II, the @entity2332 by perfusion was more rapid and deeper (11 degrees C within 10 minutes). Three hours post-operatively, cardiac function of group II was superior to that of group I as demonstrated by the increase of cardiac index (39%), @entity64 volume index (41%) mean systolic ejection rate index (44%), maximum systolic flow index (58%), maximum acceleration index (36%), @entity64 power index (88%), @entity64 work index (67%). Twenty-four and forty-eight hours post-operatively the cardio-vascular function improved in both groups but remained superior in group II. These results demonstrate that @entity2224 followed by cold coronary perfusion increases protection of the homograft during the initial period of implantation.

title: [Myocardial protection of the homograft. III - Evaluation of XXXX with hypothermic coronary perfusion (author's transl)].

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

answer: @entity2224 :: (MESH:D014693,Disease) :: ['ventricular fibrillations']


abstract: INTRODUCTION: Although cognitive behavior therapy (CBT) is the best evidenced psychological treatment for @entity1109 ( @entity1109 ), effect sizes are rather moderate. Empirically evidenced deficits in emotion processing in @entity1 with @entity1109 make a CBT enriched with an emotion regulation training (ENCERT) a promising approach to increase treatment effects. METHODS AND DESIGN: This protocol describes the development and implementation of a multicenter, randomized, active-controlled study with blinded outcome assessors to compare the efficacy of ENCERT with a conventional CBT for @entity1109 . Individuals presenting with >= 3 disabling, chronic @entity1109 and fulfilling other predefined inclusion criteria are randomized to 20 sessions either of ENCERT or conventional CBT. Power calculations are based on the severity index of the Screening of Somatoform Disorders-7T and obtained an optimal sample size of N=244. Questionnaires on symptom severity, symptom-related psychological features, and emotion regulation skills are administered at baseline, end of therapy, and 6-months follow-up. An every-session monitoring of therapy progress, and regular @entity1 '/therapists' ratings of quality of therapy, working alliance, outcome expectations, and adverse events are conducted. Primary statistical analysis shall verify the hypothesis of ENCERT being more efficacious than conventional CBT regarding symptom severity. DISCUSSION: Enriching CBT with transdiagnostic therapeutic strategies addressing emotion regulation is a promising and new approach to target not only somatic symptom coping but also symptom-associated problems and comorbid @entity146 . The current trial will not only allow examining the efficacy of ENCERT but also important variables and mechanisms of the process of therapy. TRIAL REGISTRATION: NCT01908855.

title: Enriching Cognitive Behavior Therapy with Emotion Regulation Training for XXXX with Multiple Medically Unexplained Symptoms (ENCERT): Design and implementation of a multicenter, randomized, active-controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['medically unexplained symptoms', 'MUS']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVES: To perform a population-based analysis of the potential staging or prognostic value (or both) of @entity1600 ( @entity1600 ) in @entity1 without nodal metastases vs no @entity1600 . In several previous reports, @entity1600 in @entity1 with upper tract @entity189 (UTUC) treated with nephroureterectomy (NU) was associated with better survival relative to no @entity1600 (pN(x)), even in the absence of pathologically confirmed nodal metastases (pN(0)). METHODS: Within the surveillance, epidemiology, and end results database, we identified 2824 @entity1 treated with NU for UTUC between 1988 and 2004. CSM rates after NU were graphically explored using Kaplan-Meier plots. Univariable and multivariable Cox regression models tested the effect of N(0) vs N(x) stage on CSM, after adjusting for T stage, @entity5 grade, age, gender, primary @entity5 location, type, and year of surgery. RESULTS: The CSM-free survival rate at 5 years after NU was 81.2% and 77.8% respectively for pN(0) and pN(x) @entity1 . In univariable analyses pN(x) vs pN(0) status was not associated with worse survival (HR: 1.19; P = .09). After adjustment for all covariates, pN(x) vs pN(0) status still failed to achieve independent predictor status (HR: 0.99; P = .9). CONCLUSIONS: We found no survival benefit related to the performance of @entity1600 in pN(0) @entity1 , relative to pN(x) @entity1 . Lack of standardized criteria for @entity1 ' selection for @entity1600 and for pathological lymph node specimen evaluation represents some of the explanation for the observed discrepancy between the current finding and previous findings.

title: A critical appraisal of the value of XXXX at nephroureterectomy for upper tract @entity189 .

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node dissection', 'LND']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma']

answer: @entity1600 :: (MESH:D014388,Disease) :: ['lymph node dissection']


abstract: The rates of expected serious adverse events in @entity1 with @entity3052 on chemotherapy far exceed those in @entity1 with solid @entity5 . Regulatory authorities require similar reporting criteria, which overburden the investigators and infrastructure with unnecessary documentation. To establish a baseline for expected @entity137 before and during @entity1778 therapy, we reviewed 1534 adults with @entity3052 ( @entity3052 ; excluding @entity2799 ) from 1990 to 2006 who received frontline intensive chemotherapy; 723 (47%) were 60 years or older. Prior to therapy, grade 3/4 cytopenias were observed in 86% of @entity1 . All @entity1 developed one or more grade 3/4 cytopenias during therapy, and more than 90% had a febrile episode. Admission to the intensive care unit, mechanical ventilation, and dialysis were required in 28%, 16%, and 7%, respectively. Mortality during induction, 2-week mortality, and 6-week mortality were 20%, 5%, and 16%, respectively. Grade 3/4 renal or hepatic @entity137 were observed in 3% and 22% of @entity1 , respectively. Other grade 3 or 4 @entity137 were also common before treatment and during therapy. This paper establishes a baseline @entity137 rate for @entity1 with @entity3052 during induction therapy, and this could be used as a control group for future reference. Guidelines for reporting adverse events in @entity1778 studies should be revisited.

title: Establishment of baseline @entity137 expectations with standard frontline chemotherapy in XXXX .

entities_list: @entity2799 :: ('MESH:D015473', 'Disease') :: ['acute promyelocytic leukemia']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML', 'acute leukemia']

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute myelogenous leukemia']


abstract: We have shown that a murine monoclonal antibody, B16G, recognizes a constant region determinant of a T cell suppressor factor (TsF) in DBA/2 @entity19 . The molecule recognized by B16G was shown to be a heterodimer with a native m.w. in the region of 80,000. We now show that B16G also reacts with a similar molecule derived from @entity1 lymphoid tissue. Yields of about 100 micrograms could be obtained from the solubilized membranes and cytosol from about 10(10) tonsillar cells by elution of adsorbed materials from B16G immunoadsorbent columns. As with the @entity19 system, the @entity1 TsF (HTsF) thus derived was capable of suppressing the mixed leukocyte reaction (MLR) of homologous effector T lymphocytes. However, this same material was not suppressive across the HL-A barrier, that is, when allogeneic effector cells were used in the MLR. Preliminary characterization of the HTsF showed it to have a native m.w. of 80,000 to 90,000 to be composed of a heterodimer with subunit m.w. in the region of 45,000 to 50,000, and to have an associated peptide of approximately 25,000. These observations provide evidence for the conserved nature of genes encoding TsF and correlate with observations of other investigators on the considerable homology between genes encoding the @entity19 and @entity1 T cell receptor.

title: Preliminary characterization of XXXX T cell suppressor factor (HTsF) isolated from tonsil cells by monoclonal antibody immunoadsorbence.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: 1. The characteristics of muscarinic receptors mediating relaxation and/or contraction in the @entity35 iris dilator muscle were examined. 2. Relaxation was induced in a dilator muscle by application of @entity934 ( @entity1617 ) at low doses (3 microM or less) and contraction was induced by high doses. @entity2710 and @entity5402 also showed biphasic effects similar to those of @entity1617 ; in contrast, @entity10257 , @entity6327 , @entity2134 and @entity4138 induced mainly relaxation but no substantial contraction. 3. After parasympathetic denervation by ciliary ganglionectomy, the relaxant response to muscarinic agonists disappeared upon nerve stimulation. Application of @entity4138 and @entity2134 induced only small contractions in denervated dilator muscles, indicating that these are partial agonists for contraction. 4. pA2 values of @entity4140 , @entity10258 , AF-DX 116, @entity10259 , and @entity4139 for antagonism to @entity2134 -induced relaxation in normal dilator muscles and those for antagonism to @entity1617 -induced contraction in denervated dilator muscles were determined. The pA2 values for antagonism to relaxation of all these antagonists were most similar to those for M3-type muscarinic receptors. 5. Although pA2 values for contraction of these antagonists, except for @entity10258 , were very close to those for relaxation, contraction was not significantly antagonized by @entity10258 . Contraction might be mediated by M3-like receptors which have a very low affinity for @entity10258 . 6. In conclusion, @entity1617 -induced biphasic responses in @entity35 iris dilator muscles were clearly distinguished from each other by specific muscarinic agonists and parasympathetic denervation, whereas muscarinic receptors could not be subclassified according to the pA2 values of 5 specific antagonists only.

title: Characterization of muscarinic receptors mediating relaxation and contraction in the XXXX iris dilator muscle.

entities_list: @entity10258 :: ('MESH:C054938', 'Chemical') :: ['methoctramine']

entities_list: @entity2134 :: ('MESH:D010862', 'Chemical') :: ['pilocarpine']

entities_list: @entity6327 :: ('MESH:D001115', 'Chemical') :: ['arecoline']

entities_list: @entity10257 :: ('MESH:D018723', 'Chemical') :: ['bethanechol']

entities_list: @entity4140 :: ('MESH:D010890', 'Chemical') :: ['pirenzepine']

entities_list: @entity2710 :: ('MESH:D016210', 'Chemical') :: ['Methacholine']

entities_list: @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol']

entities_list: @entity10259 :: ('MESH:C048172', 'Chemical') :: ['himbacine']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: This prospective study was designed to assess the prognostic value of @entity5 -associated antigens, designated 19A211, M344, T138, and T43, with respect to recurrence of primary @entity150 . Between September 1990 and April 1992, all @entity1 with primary superficial @entity150 treated by endoscopic resection in 15 participating hospitals were enrolled. Immunostaining for 19A211 and M344 was performed on paraffin-embedded material, and for T43 and T138 on frozen tissue. Antigenic expression was evaluated blindly by a single pathologist. @entity1 were followed up with the standard schedule of control cystoscopies. Cox regression was used to estimate hazard ratios (HRs) for first recurrence, and Poisson regression was used to estimate recurrence rate ratios and @entity5 rate ratios adjusted for primary @entity5 characteristics. By March 1994, 2254 follow-up cystoscopies had been performed on 368 of the 382 study @entity1 , and @entity5 recurrence was detected in 55.7% of @entity1 . Positivity to 19A211 was detected in 90% of @entity5 , its expression being associated with a decrease in first recurrence hazard ]HR, 0.65; 95% confidence interval (CI), 0.42-1.03] and in recurrence rate (recurrence rate ratio, 0.70; 95% CI, 0.53-0.92). Positivity to T138 was detected in 15% of @entity5 , and its expression was associated with an increase in first recurrence hazard (HR, 1.43; 95% CI, 0.92-2.22) and in recurrence rate (recurrence rate ratio, 1.31; 95% CI, 1.00-1.72). Positivity to M344 was detected in 71% of @entity5 , and its expression was associated with an increase in @entity5 rate ( @entity5 rate ratio, 1.77; 95% CI, 1.41-1.97). T43 expression was not associated with recurrence end points. In conclusion, recurrence of @entity150 was associated with antigenic expression of 19A211, T138, and M344, independently of primary @entity5 characteristics.

title: Tumor-associated antigens as prognostic factors for recurrence in 382 XXXX with primary transitional cell @entity150 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['superficial bladder cancer', 'bladder tumors']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: We report a @entity1 with @entity1737 who experienced a relapse 13 years after apparently successful treatment by mediastinal irradiation and @entity228 therapy. A 20-year-old male was admitted to Shinshu University Hospital with a chief @entity892 and drooping eyelids. These symptoms had appeared 2 months prior to admission. They tended to be more severe late in the day, and varied from day to day. Prior to this admission the @entity1 had been healthy for the 13 years since undergoing 45-Gy mediastinal irradiation and corticosteroid therapy. MRI and CT studies revealed no @entity8792 . Total thymectomy was performed, and his myasthenic symptoms, including the opthalmoplegia, improved. Histological examination of the resected thymus revealed an active thymus with germinal centers. Immunohistological studies showed an abundance of @entity2071 ( @entity2071 ) in the germinal centers and thymic medullary epithelium, and the presence of @entity1453 ( @entity1453 ) in thymic lymphocytes. @entity2071 and @entity1453 are ligand of adhesion molecules which interact with each other and play an important role in antigen presentation. @entity934 receptor (ACh-R) antigen is known to be present in the thymus. The presence of both @entity2071 and @entity1453 in the active thymus in this @entity1 suggests that these adhesion molecules may have a role in ACh-R antigen presentation, causing @entity1737 . These findings suggest that @entity1 with @entity1737 who do not undergo total thymectomy have a risk of recurrence, even after long-term remission.

title: [A XXXX with a relapse of @entity1737 after a 13-year remission following successful treatment by mediastinal irradiation and corticosteroid therapy].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia', 'myasthenia gravis']

entities_list: @entity8792 :: ('MESH:D013952', 'Disease') :: ['thymic hyperplasia']

entities_list: @entity1453 :: ('3683', 'Gene') :: ['LFA-1', 'lymphoid function-associated antigen-1']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['complain double vision']

entities_list: @entity2071 :: ('3383', 'Gene') :: ['ICAM-1', 'intracellular adhesion molecule-1']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['Acetylcholine']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: OBJECTIVE: The aim of the study was to find out if single time point and estimated cumulative release of @entity10020 ( @entity10020 ) and @entity908 kinase (CK) correlate with early @entity1188 size and left ventricular function measured by cardiac magnetic resonance (CMR). METHODS: CMR and serial CK and @entity10020 measurements were performed in 103 @entity1 (85 male, mean age 55.8    12.1 years) within at least 8 days (3.1    1.5 days) after first @entity583 and successful primary percutaneous coronary interventions. @entity1188 size was determined on delayed @entity2287 -enhanced phase-sensitive IR-SSFP CMR sequences. Single time point, peak and cumulative cardiac protein release were correlated with @entity1188 size. RESULTS: All single time point, peak and estimated cumulative release of CK and @entity10020 values except on admission showed significant correlations with @entity1188 size. Among single time point values, @entity10020 after 96 h ( @entity10020 (96); r = 0.680, p < 0.001) and CK after 24 h (CK(24); r = 0.699, p < 0.001) showed the closest correlations with @entity1188 size. Peak CK and @entity10020 levels correlated only slightly better than single time point values (r = 0.703 and 0.688, p < 0.001), whereas cumulative release values did not show closer correlations than single point values. Receiver-operator characteristics analysis showed that @entity10020 (96) and CK(24) detected large @entity1188 areas (>16.8 g) and decreased left ventricular function (EF < 40%) with high sensitivity and specificity. CONCLUSION: Both single time point @entity10020 concentrations and CK activities correlate well with @entity1188 size early after primary PCI for STEMI. Cardiac TnT levels determined 3-4 days after revascularization for @entity583 allow for a good estimation of @entity1188 as well as an approximation of LV function and morphology.

title: Role of biomarkers in assessment of early XXXX size after successful p-PCI for STEMI.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity10020 :: ('7139', 'Gene') :: ['cTnT', 'cardiac troponin T']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['Infarct', 'acute infarct size', 'infarct']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['infarct']