abstract: OBJECTIVES: At our institution, a standardized protocol using magnetic resonance imaging (MRI) to evaluate ankle stability and need for surgery following a positive manual stress test for isolated lateral @entity174 has been used. The purpose of this study was to evaluate the results using this standardized protocol. DESIGN: Retrospective review. SETTING: University teaching hospital. @entity1 : : Twenty-one @entity1 who had a positive ankle stress test (>or=5 mm clear space widening) after isolated Weber B @entity1171 were further evaluated by MRI to determine the status of the deep deltoid ligament. INTERVENTION: If the MRI showed the deltoid ligament was completely disrupted, the @entity1 was advised to have operative ankle repair. However, if the MRI demonstrated that the deep deltoid was intact or only partially disrupted, the @entity1 was treated nonoperatively in a walking boot with weightbearing as tolerated ambulation. MAIN OUTCOME MEASUREMENT: @entity1 were followed until @entity174 union and contacted at 12-month minimum follow-up to determine outcomes by radiographic evaluation, health related quality of life (HRQOL) based on Short Form (SF)-36 results and functional outcomes based on the American Orthopaedic Foot and Ankle (AOFAS) and @entity1 report of treatment satisfaction. RESULTS: Twenty-one @entity1 had an MRI after a positive ankle stress test and comprised the study group. There were 12 @entity1 and 9 @entity1 with an average age of 27 years (range, 16-62 years). Absolute medial clear space measurement on stress testing ranged from 5 to 8 mm. In all, 19 of 21 @entity1 (90%) had evidence of partially torn deep deltoid ligament on MRI and were treated nonoperatively, whereas two @entity1 had MRI findings of a complete @entity130 and underwent surgical treatment. There were no statistically significant correlations between the medial clear space measurements and MRI documentation of complete deltoid ligament rupture. All @entity174 united without evidence of residual medial clear space widening or posttraumatic joint space narrowing. Of the 15 @entity1 who were available for 1 year minimum follow-up and agreed to come back for clinical and radiographic evaluation, 14 had an AOFAS score of 100, with the remaining @entity1 having a score of 85. HRQOL based on SF-36 results indicated all @entity1 were above or at normal levels, and all @entity1 reported that they were satisfied with their treatment; 93% (14/15) indicated that they would make the same treatment decision again. CONCLUSIONS: Using our protocol, we were able to identify and provide effective nonoperative care to 19 @entity1 who otherwise might have underwent operative treatment after an isolated @entity1171 . Further work is needed to identify the subset of @entity1 who could be treated nonoperatively without a need for MRI scanning.

title: Does a positive ankle stress test indicate the need for operative treatment after XXXX ? A preliminary report.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity1171 :: ('MESH:D064386', 'Disease') :: ['lateral malleolus fracture']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['deep deltoid injury']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'malleolus fractures']

answer: @entity1171 :: (MESH:D064386,Disease) :: ['lateral malleolus fracture']


abstract: UNASSIGNED: @entity1311 ( @entity4045 ) which easily elutes into ascites is widely used to treat @entity356 @entity1 with @entity298 ( @entity298 ), but clinical outcomes are suboptimal. Increased concentrations of a1-acid glycoprotein (AGP), an important drug-binding protein, have been reported in the plasma and ascites of @entity5 @entity1 . This study sought to clarify whether AGP binds to @entity4045 and alters its anticancer effects. AGP concentrations were measured in the serum and ascites of @entity356 @entity1 with @entity298 and in the serum of healthy volunteers. The in vitro effects of AGP and AGP plus @entity2929 (EM) on @entity4045 were evaluated by @entity98 assays in the @entity356 cell lines. We also measured AGP concentrations in the ascites of @entity298 model @entity19 and examined the effects of EM plus @entity4045 on @entity298 . The mean AGP concentrations in the serum and ascites of @entity356 @entity1 with @entity298 were 1524 and 834   g/mL, respectively, higher than the mean AGP concentration of 650   g/mL observed in the sera of healthy volunteers. AGP  >  400   g/mL significantly suppressed the cell growth inhibitory effect of @entity4045 in vitro, but the co-administration of EM restored it. Elevated AGP concentrations were observed in the ascites of @entity298 model @entity19 . Administration of @entity4045 alone did not markedly diminish @entity298 , whereas co-administration of @entity4045 and EM significantly reduced @entity298 (p  =  0.011). AGP is an important regulatory factor modulating the anticancer activity of intraperitoneal @entity4045 . The co-administration of @entity4045 and EM may be effective in treating @entity356 @entity1 with @entity298 .

title: Elevated alpha1-acid glycoprotein in @entity356 XXXX inhibits the anticancer effects of @entity1311 , effects restored by co-administration of @entity2929 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis', 'PC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['Paclitaxel']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND/AIM: [corrected] @entity3807 ( @entity3807 ) is an uncommon disease characterized by a retroperitoneal fibrotic tissue that often involve the ureters, leading to the obstructive @entity8 and variable @entity8 . Findings strongly suggest an autoimmune etiology. Surgery, medical treatment with immunosuppressive drugs, or a combination of both are proposed. The optimal treatment has not been established yet. The aim of this study was to present our experience with combined immunosuppressive therapy of @entity3807 , @entity230 (S) and @entity618 ( @entity2098 ). METHODS: We prospectively followed four @entity1 with @entity3807 from January 2004 to December 2006. Three @entity1 had an active disease with bilateral @entity3041 . In the two of them @entity810 was presented, and ureteral catheters were inserted in one in order to manage @entity1695 . One @entity1 has came to our unit with a relapse of @entity3807 and incipient @entity177 after the prior therapy with ureterolysis and immunosuppressive drugs ( @entity500 and @entity440 ). All @entity1 received @entity230 and MMF. Two @entity1 were treated with intravenous @entity1667 pulses (250 mg each), for three consecutive days, followed by oral @entity229 0.5 mg/kg/day. The other two @entity1 received oral @entity229 at the same dose. @entity229 was gradually tappered to a maintenance dose of 10 mg/kg/day. Simultaneously, all @entity1 received MMF, initially 1 g/day with the increase to 2 g/day. RESULTS: After four weeks of the therapy all symptoms disappeared, as well as a @entity3041 with a decrease of erythrocyte sedimentation rate and Creactive protein (CRP) to normal level in all @entity1 . Three patents remain in remission untill the end of the follow up. One @entity1 had a relapse because of stopping taking the therapy after six months. He was treated by oral @entity229 0.5 mg/kg/day, which was gradually decreased. After twelve weeks @entity3041 disappeared and CRP returns to the normal level. CONCLUSION: The combination of @entity230 and @entity618 led to the remission of @entity3807 with a strong and quick immunosuppressive effect. It also provided avoiding the long-term use of high @entity134 dose and surgical procedures.

title: [ @entity618 combined with @entity230 : new experiences in the treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'impairment of renal function']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity3807 :: ('MESH:D012185', 'Disease') :: ['IRF', 'Idiopathic retroperitoneal fibrosis']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['ureteral obstruction']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['Prednisone', 'prednisone']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity3807 :: (MESH:D012185,Disease) :: ['idiopathic retroperitoneal fibrosis']


abstract: We evaluated the predictive value of wandering behavior at baseline for nutritional status, disability, institutionalization, and mortality in 686 @entity195 community-dwelling subjects enrolled in the prospective REAL.FR study, France. Wandering behavior was defined using the Neuro-Psychiatric Inventory. The Mini-Nutritional Assessment and Katz Activity of Daily Living (ADL) scale were administered every 6 months during the 2 years of the study. @entity303 severity was assessed using the Mini-Mental State Examination. @entity146 , comorbidities, medication, health care support, and burden status of the caregiver were assessed at the baseline visit. Outcomes of the 83 (12.2%) wanderers were compared with those of the nonwanderers. In the whole sample 30.1%/year subjects lost weight, 27.8%/year worsened their nutritional status, 55.1%/year decreased their ADL score, 11%/year reduced their ability to walk, 13.5%/year were institutionalized, and 6.2%/year died. Wanderers differed from nonwanderers by a higher frequency of decline of the ADL score (P<0.001), and institutionalization (P<0.001). Adjusted for baseline characteristics, risk of worsening the nutritional status, @entity353 , decreased ADL score, and @entity204 were not statistically different between wanderers and nonwanderers. Risk for undernutrition and @entity204 are not increased in wanderers. Their higher risk of ADL disabilities and institutionalization are partly explained by their baseline characteristics.

title: Wandering behavior and XXXX . The REAL.FR prospective study.

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Behavioral disturbances']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer disease']


abstract: BACKGROUND: Bipolar @entity1 show high intra-individual variability during cognitive processing. However, it is not known whether there are a specific fluctuations of variability contributing to the overall high cognitive inconsistency. The objective was to compare dynamic profiles of @entity1 and healthy controls to identify hypothetical differences and their associations with overall variability and processing speed. METHODS: Changes of reaction times iSD during processing speed test performance over time was measured by dividing the iSD for whole task into four consecutive parts. Motor speed and cognitive effort were controlled. RESULTS: @entity1 with @entity2403 exhibited significantly lower results regarding processing speed and higher intra-individual variability comparing with HC. The profile of intra-individual variability changes over time of performance was significantly different in @entity2403 versus HC groups: F(3, 207)=8.60, p<0.0001,   p(2)=0.11. iSD of @entity2403 @entity1 in the initial phase of performance was three times higher than in the last. There was no significant differences between four intervals in HC group. Inter-group difference in the initial part of the profiles was significant also after controlling for several cognitive and clinical variables. LIMITATIONS: Applied computer version of Cognitive Speed Test was relatively new and, thus, replication studies are needed. Effect seen in the present study is driven mainly by the @entity2403 type I. CONCLUSIONS: @entity1 with @entity2403 exhibits problems with setting a stimulus-response association in starting phase of cognitive processing. This deficit may negatively interfere with the other cognitive functions, decreasing level of psychosocial functioning, therefore should be explored in future studies.

title: Cognitive inconsistency in bipolar XXXX is determined by increased intra-individual variability in initial phase of task performance.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The potential for radioimmunotherapy as an adjuvant treatment for early disseminated @entity694 was investigated in an experimental lung @entity3 model. @entity19 receiving intravenous injection with a suspension of @entity1 @entity694 cells (GW-39) developed multiple (10-100) @entity5 nodules throughout the lungs, and more than 50% of the animals died of extensive @entity5 involvement within 5-10 weeks. Groups of eight or nine animals bearing 7-day-old @entity5 transplants were treated with a single intravenous injection of radioiodinated agents: either 0.15 or 0.30 mCi of whole IgG of the @entity7134 murine monoclonal antibody (MAb) against @entity787 ( @entity787 ) or 0.15 or 0.30 mCi of whole IgG of Immu-31, an anti-alpha-fetoprotein (anti-AFP) MAb. Treatment of animals with 0.15 or 0.30 mCi of 131I-labeled @entity7134 IgG 7 days after injection of @entity5 cells resulted in survival for 23 weeks after @entity5 implantation in four of eight and seven of nine animals, respectively. Microscopic examination revealed that over 90% of the @entity2 colonies had no evidence of surviving cells. Animals treated with 0.30 mCi of anti-AFP, an irrelevant MAb, survived 4 weeks longer than controls. @entity137 was evident in four of the 17 animals given 0.30 mCi of @entity7134 IgG (specific) or anti-AFP IgG (irrelevant) MAb. These animals died within 1-3 weeks after radioantibody injection, suggesting that @entity204 was related to the radiation dose. None of the animals given 0.15 mCi of 131I-MAb died within this period.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Successful radioimmunotherapy for lung @entity3 of @entity1 XXXX in @entity19 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Toxicity']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumor']

entities_list: @entity787 :: ('1084', 'Gene') :: ['CEA', 'carcinoembryonic antigen']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic cancer']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colonic cancer']


abstract: BACKGROUND: The impact that smoking cigarettes has on the characteristics and survival of @entity1 with @entity1149 ( @entity1149 ) is disputed. METHODS: A retrospective cohort study using a prospective database of @entity1 with @entity1149 over a 6-year period. Clinical and histologic characteristics and survival rates were compared between smokers and never-smokers. RESULTS: There were 730 @entity1 ; 562 @entity1 (77%) were smokers and 168 @entity1 (23%) were never-smokers. The overall 5-year survival rate was greater in never-smokers (64%) compared to smokers (56%; p = 0.031). Never-smokers were more likely to be younger (p = 0.04), female (p = 0.01), symptomatic at the time of presentation (p < 0.001), have poorly differentiated @entity5 (p = 0.04), and have a higher maximum standardized uptake value (maxSUV) on positron emission tomography (PET) (p = 0.026) than smokers. The stage-specific 5-year survival rate was greater for never-smokers compared to smokers for stage I disease (62% vs 75%, respectively; p = 0.02), @entity34 (46% vs 53%, respectively; p = 0.09), and @entity5 (36% vs 41%, respectively; p = 0.13). The 5-year survival rate was significantly lower in @entity1 who had a smoking history of > 20 pack-years. CONCLUSIONS: Never-smokers in whom @entity1149 develops are more likely to be young, female, and have poorly differentiated @entity5 with higher maxSUV values on PET scans. Never-smokers with early-stage @entity5 have a significantly better survival rate than smokers. @entity1 with a smoking history of > or = 20 pack-years have worse survival. Thus, smoking not only causes @entity2 , but once @entity1149 is diagnosed, the prognosis becomes worse. A biological, hormonal, and genetic explanation is currently lacking to explain these findings, and these data may help to improve treatment and surveillance.

title: Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III disease', 'cancer', 'tumors']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: Despite the beneficial effects of @entity172 in @entity1 's health, there is a plethora of evidence that suggest an important role for these hormones, particularly @entity53 (E(2)), in the development and progression of @entity0 . Most estrogenic responses are mediated by @entity172 receptors (ERs), either @entity1782 or @entity1783 , which are members of the nuclear receptor superfamily of ligand-dependent transcription factors. Selective @entity172 receptor modulators (SERMs) are ER ligands that in some tissues (i.e. @entity65 ) act like @entity172 but block @entity172 action in others. @entity440 is the first SERM that has been successfully tested for the prevention of @entity0 in high-risk @entity1 and is currently approved for the endocrine treatment of all stages of ER-positive @entity0 . @entity441 , a newer SERM originally developed for @entity170 , also appears to have preventive effect on @entity0 incidence. Numerous studies have examined the molecular mechanisms for the tissue selective action of SERMs, and collectively they indicate that different ER ligands induce distinct conformational changes in the receptor that influence its ability to interact with coregulatory proteins (i.e. coactivators and corepressors) critical for the regulation of target gene transcription. The relative expression of coactivators and corepressors, and the nature of the ER and its target gene promoter also affect SERM biocharacter. This review summarizes the therapeutic application of SERMs in medicine; particularly @entity0 , and highlights the emerging understanding of the mechanism of action of SERMs in select target tissues, and the inevitable development of resistance.

title: Selective XXXX receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['Tamoxifen']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['17beta-estradiol']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['bone and cardiovascular system']

entities_list: @entity441 :: ('MESH:D020849', 'Chemical') :: ['Raloxifene']

answer: @entity172 :: (MESH:D004967,Chemical) :: ['estrogen']


abstract: BACKGROUND: Syncope is a frequent complaint in @entity1 and adolescents and may be a significant sign of serious pathology. Although @entity1 history, family history, and physical examination are sufficient to reach a diagnosis in most cases of @entity1163 , the cause of @entity1163 cannot be determined after initial investigation in one-third to half of all @entity1 . The aim of this study was to evaluate the diagnostic yield of implantable loop recorder (ILR) in @entity1 with unexplained @entity1163 . METHODS: A retrospective review was carried out of clinical data, indications, findings, and a final management strategy in @entity1 who underwent ILR implantation. RESULTS: A total of 12 @entity1 with a mean age of 9.4    4.5   years underwent ILR (Reveal Plus; Medtronic) implantation. ILR implantation indication was @entity1163 in all of the @entity1 . Family history, routine cardiac assessment, including resting 12-lead electrocardiogram, transthoracic echocardiography, 24   h Holter recording, and event recorder findings, were normal with the exception of one @entity1 with (previously corrected) tetralogy of Fallot. After an average of 20   months (range, 1-36   months), six @entity1 developed symptoms. ILR memory showed @entity2224 (n = 3), catecholaminergic polymorphic @entity1165 (n = 1), @entity1167 and @entity1165 (n = 1), and normal sinus rhythm (n = 1). At the time of writing six @entity1 were still in follow up with no symptoms after an average of 25.2   months. CONCLUSION: Implantable loop recorder plays an important role in the diagnosis of life-threatening @entity943 in which @entity1163 is otherwise unexplained. ILR implantation should be remembered in @entity1 whose symptoms are strongly correlated with rhythm disturbances.

title: Evaluation rhythm problems in unexplained XXXX etiology with implantable loop recorder.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope still', 'syncope']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['torsades de pointes-ventricular fibrillation']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

answer: @entity1163 :: (MESH:D013575,Disease) :: ['syncope']


abstract: PURPOSE: The classification of @entity302 and @entity302 recognizes three syndromes with typical absences [TA, i.e., childhood and @entity2048 ( @entity11305 ), and @entity3148 ( @entity3148 ), none of which is characterized by onset in early childhood]. Although several other forms of @entity2048 have been described recently, none concerns @entity1 and very young @entity1 , and little is known about the nosology and prognosis of early-onset absences. METHODS: We retrospectively selected all cases with onset of absences as the only or major @entity410 type before age 3 years and >/=2 years of follow-up among cases newly referred between 1986 and 2002. Neuropsychological assessments (generally IQ measure), behavior patterns, and schooling situations were reviewed for each @entity1 . RESULTS: We found 10 @entity1 (7 F, 3 M). No @entity1 had sensory or motor deficits: neuroimaging was performed in nine and was normal in eight, with aspecific findings in one. Only two could be characterized as @entity11305 and @entity3148 , respectively, both with @entity410 control and a good cognitive outcome. Among the remaining eight cases, four had a fairly homogeneous presentation with predominantly brief absences and clearly asymmetric interictal EEGs. All eight had neuropsychological and/or behavioral difficulties. Three had full @entity410 control, and five, persisting absences, with a follow-up ranging between 2 years 8 months to 9 years 4 months; only one @entity1 was older than 12 years. CONCLUSIONS: Great heterogeneity exists among @entity2048 of early onset, which are rare conditions. Only a few @entity1 can be categorized into well-known syndromes. The overall prognosis is poor. Early onset of absences is uncommon, and multicenter studies should help clarify the nosology and prognosis.

title: XXXX with onset before age three years: a heterogeneous and often severe condition.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants', 'child']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsies', 'epileptic syndromes']

entities_list: @entity2048 :: ('MESH:D004832', 'Disease') :: ['absence epilepsies', 'juvenile absence epilepsies']

entities_list: @entity3148 :: ('MESH:D004831', 'Disease') :: ['EMA', 'epilepsy with myoclonic absences']

answer: @entity2048 :: (MESH:D004832,Disease) :: ['Absence epilepsy']


abstract: BACKGROUND: Scattered patches of @entity17110 , one form of @entity1355 , were found in the surface soil in the rural county of Da-yao in southwestern China. In 1983, researchers from the West China University of Medical Sciences (WCUMS) discovered that residents of two villages in Da-yao had hyperendemic @entity456 and excessive numbers of @entity2615 . AIMS: To review and summarise epidemiological studies, along with other relevant data, and to discuss the potential contribution to environmental risk assessment. METHODS: This report is based on a review of several clinical/epidemiological studies conducted by WCUMS researchers since 1984, which included one cross sectional medical examination survey, one clinical/pathological analysis of 46 cases of @entity2615 , and three retrospective cohort mortality studies. Additional information acquired from reviewing original data first hand during a personal visit along with an interview of medical specialists from Da-yao County Hospital was also incorporated. RESULTS: The prevalence of @entity456 was 20% among peasants in Da-yao over 40 years of age in the cross sectional survey. The average number of @entity2615 cases was 6.6 per year in the 1984-95 period and 22 per year in the 1996-99 period, in a population of 68 000. For those @entity2615 cases that were histology confirmed, there were 3.8 cases/year in the first period and 9 cases/year in the second. Of the 2175 peasants in this survey, 16 had @entity1355 . Lung @entity5 were significantly increased in all three cohort studies. The annual mortality rate for @entity2615 was 85 per million, 178 per million, and 365 per million for the three cohort studies, respectively. The higher exposed peasants had a fivefold increased @entity2615 mortality compared to their lower exposed counterparts. There were no cases of @entity2615 in the comparison groups where no @entity17110 was known to exist in the environment. In the third cohort study, almost one of five @entity5 (22%) was from @entity2615 . The ratio of @entity2 to @entity2615 deaths was low for all three studies (1.3, 3.0, and 1.2, respectively). CONCLUSIONS: The observation of numerous @entity2615 cases at Da-yao was a unique finding, due mainly to their lifetime exposure to @entity17110 @entity1355 . The finding of cases dying at a younger age and the relatively high ratio of @entity2615 cases to @entity2 could also be another unique result of lifetime environmental exposure to @entity17110 @entity1355 . Although the commercial use of @entity17110 has been officially banned since 1984, the incidence of @entity2615 has continued to show a steady increase, particularly among peasants. Since the latency of @entity2615 is approximately 30-40 years, the ban had little effect in the 1990s. The increased awareness and changes in diagnosis over time may also contribute to the increase. Furthermore, exposure to @entity1355 stoves and walls continued. The government implemented reduction of these exposures. However, from a public health standpoint, the most important issue is the complete avoidance of further exposure to @entity1355 .

title: Asbestos related diseases from environmental exposure to XXXX in Da-yao, China. I. Review of exposure and epidemiological data.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer deaths']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['pleural mesotheliomas', 'mesothelioma']

entities_list: @entity17110 :: ('MESH:D017638', 'Chemical') :: ['crocidolite']

entities_list: @entity1355 :: ('MESH:D001195', 'Disease') :: ['asbestos', 'asbestosis']

entities_list: @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural plaque', 'pleural plaques']

answer: @entity17110 :: (MESH:D017638,Chemical) :: ['crocidolite']


abstract: BACKGROUND: In the European Randomized Study of Screening for @entity263 (ERSPC, Rotterdam region), @entity1 aged 55-74 years are screened for @entity263 by prostate-specific antigen (PSA) sampling, digital rectal examination (DRE), and transrectal ultrasound investigation (TRUS). All @entity1 with a PSA > or =4 ng/ml and/or a suspicious DRE and/or a suspicious TRUS are biopsied. METHODS: Logistic regression analysis was applied to derive a predictive index that equals the chance to find @entity263 in a biopsy given the outcomes of the screening tests. This model was used to assess the number of @entity5 that could have been detected if all @entity1 had been biopsied (extrapolation). Furthermore, the model was used to study the possibilities for improvement of the current screening protocol. RESULTS: PSA was the dominant predictor for @entity263 in a biopsy, followed by prostate volume, DRE, and TRUS result. It is assessed that 69% (95% CI, 52-86%) of @entity5 that could be identified if all @entity1 were biopsied are currently detected. Application of the same methods to screening data obtained in G  teborg (the Swedish ERSPC partner) yielded almost identical results. It was found that, in the Rotterdam protocol, a considerable number of @entity1 were biopsied according to the screening protocol with an assessed lower chance to have @entity263 than @entity1 who were not biopsied according to the protocol. CONCLUSIONS: The chance to detect @entity263 in a biopsy can be modeled quite accurately as a function of serum PSA, prostate volume, DRE, and TRUS results. Important improvements in the screening protocol can be achieved by the application of the predictive index.

title: Predictors for biopsy outcome in the European Randomized Study of Screening for XXXX (Rotterdam region).

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostate Cancer', 'prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

answer: @entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']


abstract: Aim. @entity102 are the leading cause of @entity204 worldwide. Advanced glycation end products, known as AGEs, are a major risk factor for @entity6 onset and maintenance. @entity14625 (MG), a highly reactive metabolite of @entity413 , is a precursor for the generation of endogenous AGEs. Methods. In this current study we incubated in vitro pancreatic islets from adult @entity35 in absence or presence of MG (10    mol/l) with different concentrations of @entity413 and different metabolic components ( @entity934 , @entity1425 , @entity972 , @entity1928 , and @entity368 ). Results. Different effects of MG on insulin secretion were evidenced. In basal @entity413 stimulation (5.6   mM), MG induced a significant (P < 0.05) increase of insulin secretion. By contrast, in higher @entity413 concentrations (8.3   mM and 16.7   mM), MG significantly inhibited insulin secretion (P < 0.05). In the presence of @entity972 , @entity1928 , and @entity1425 , MG enhanced insulin secretion (P < 0.05), while when it was incubated with @entity934 and @entity368 , MG resulted in a decrease of insulin secretion (P < 0.05). Conclusion. We suggest that MG modulates the secretion activity of beta-cell depending on its level of stimulation by other metabolic factors. These results provide insights on a dual acute effect of MG on the pancreatic cells.

title: Acute exposure to a precursor of advanced glycation end products induces a dual effect on the XXXX pancreatic islet function.

entities_list: @entity14625 :: ('MESH:D011765', 'Chemical') :: ['Methylglyoxal']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic diseases']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES/HYPOTHESIS: To determine whether changes in demographics and management of @entity1 with @entity5513 occurred between the years 1990 and 2005. STUDY DESIGN: Retrospective chart review. METHODS: Charts of all 614 @entity1 with a diagnosis of @entity5513 , excluding @entity8605 , from 1990 through 2005 were reviewed. Age at diagnosis, @entity5 size, hearing, and initial therapy (observation, stereotactic radiation, or surgical excision) were obtained. @entity1 were grouped by time period (1990-1994, 1995-2000, 2001-2005). RESULTS: Mean age at diagnosis increased slightly from the middle period (53.4 yr) to the most recent (56.9 yr) (P < or = .025). The proportion of @entity1 65 years or older increased from 21% to 29% to 32%, respectively, but the change was not significant. Average @entity5 size decreased from 1.7 cm initially to 1.4 cm most recently (P < or = .039). There were no significant changes in hearing. Although surgical excision remains our most common treatment (58.5% in 2001-2005), it is becoming less frequent (>80% in earlier periods) (P < or = .001). Observation with serial imaging was recommended in 37.3% in 2001 to 2005 as compared with 18.3% and 11.6% in the previous two time periods (P < or = .001). These changes in initial treatment choices occurred for all age groups and primarily for small @entity5 . Use of radiation has increased only slightly, to 4.2% in the recent period. CONCLUSION: : @entity1 with @entity5513 are presenting with increased age and smaller @entity5 compared with 16 years ago. However, these changes cannot totally account for the large change in treatment trends. Technology and demographics are influential in these changes, but other difficult to measure forces, such as @entity1 influence and @entity1 use of the Internet, are also factors.

title: XXXX in a private neurotology practice: trends in demographics and practice patterns.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5513 :: ('MESH:D009464', 'Disease') :: ['acoustic neuromas', 'acoustic neuroma']

entities_list: @entity8605 :: ('MESH:D016518', 'Disease') :: ['neurofibromatosis-2']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity5513 :: (MESH:D009464,Disease) :: ['Acoustic neuroma']


abstract: @entity375 extract (YE) is commonly used as a key component in the complex media for industrial fermentations. However, the lot-to-lot variation of this raw material frequently requires extensive "use testing" of many lots to identify only the few that support desired fermentation performance. Through extensive fermentation studies and chemical analyses, we have identified @entity5536 and two metabolizable @entity505 sources, @entity7970 and @entity880 , as the principle components in YE that affect the production of a recombinant protein antigen by a @entity375 . @entity5536 is required for culture growth and the relationship between biomass and measured @entity5536 can be expressed by a Michaelis-Menten model, while the slowly metabolized @entity7970 serves to maintain the energy supply to the continued antigen synthesis. The rapidly utilized @entity880 exerts an indirect positive effect by sparing some of the accumulated @entity1068 from being consumed for growth to being utilized in the product formation. The effects of these YE components are mutually dependent. Based on the database generated from 40 lots at laboratory scale, a relatively high level of @entity505 sources in YE ( @entity7970 plus @entity880 , >9.5% w/w) and an intermediate level of @entity5536 (0.14-0.24% w/w) appear to be the minimal requirement of a good lot for this recombinant @entity375 fermentation. Many poor lots were improved in lab fermenters by rational supplementation of @entity7970 , @entity880 , or @entity5536 to compensate for their insufficiencies. At the large production scale, predictions based on @entity5536 and @entity7970 / @entity880 contents in various YE lots used correlated reasonably well with culture growth and antigen yield, illustrating the feasibility of such a simple chemical/biochemical analysis as a rapid and reliable initial screening tool. Without incurring any compositional change to an established manufacturing medium, this study demonstrates an effective approach to achieve consistency in fermentations employing complex nutrients and to improve fermentation productivities supported by suboptimal lots of raw material.

title: Toward consistent and productive complex media for industrial fermentations: studies on @entity375 extract for a recombinant XXXX fermentation process.

entities_list: @entity7970 :: ('MESH:D014199', 'Chemical') :: ['trehalose']

entities_list: @entity5536 :: ('MESH:D000225', 'Chemical') :: ['Adenine', 'adenine']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity375 :: ('4932', 'Species') :: ['yeast strain', 'yeast', 'Yeast']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: Apoptosis and proliferation are very important processes during central nervous system development. In our study we concentrated on @entity1 fetus retina, regio respiratoria and olfactoria. The aims of our work were to evaluate a proliferative activity proved by @entity1364 and KI-67 gene expressions, to measure an expression of anti-apoptotic gene @entity588 , and finally to compare levels of apoptosis and proliferation in the areas investigated. Altogether we studied 29 fetuses between the 5th to 13th @entity6677 ( @entity6677 ). Parallel sections were elaborated by using standard methods of immunohistochemistry for the detection of proteins @entity1364 , @entity588 and Ki-67. Apoptotic cells were detected by two methods: TUNEL (for the detection of DNA fragmentation) and Apostain (for evidence of ssDNA). The results of semiquantitative evaluation show that expressions of proteins @entity1364 and KI-67 begins after the 6th @entity6677 , from the 8th to 13th @entity6677 they are very high in all investigated areas. Occurrence of apoptotic cells in regio respiratoria is sporadic between the 5th to 9th @entity6677 , while later it is widely spread. Apoptosis in regio olfactoria appears after the 9th @entity6677 and it is also very extensive. In the retina we found a higher frequency of apoptotic cells only in the 11th to 13th @entity6677 . The results of both methods for detection of apoptosis were concordant. Anti-apoptotic gene @entity588 was detectable in all examined areas, but it followed no orderly pattern. We conclude, that the expression of apoptosis increases with the age from the 7th to 13th @entity6677 , and that both apoptosis and proliferation participate in the morphogenesis of fetuses between the 5th to 13th @entity6677 .

title: Role of apoptosis and proliferation in differentiation of XXXX retina, regio olfactoria and regio respiratoria.

entities_list: @entity6677 :: ('MESH:D016640', 'Disease') :: ['week of gestation', 'WG']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: Clinical chronic @entity9 is often resistant to currently used pharmacotherapeutic applications. A number studies have shown that pulsed magnetic field (PMF) application may ameliorate the @entity158 associated with damages, surgeries or diseases. However, possible potential mechanisms of PMF treatments have not been well documented. This study aimed to assess the therapeutic effects of PMF treatment on a @entity8638 model (CCI) which mimics clinical chronic @entity9 . MATERIALS AND METHODS: Effects of PMF treatments or sham PMF (SPMF) were investigated by measuring the latencies, thresholds and cytokine levels (interleukin [IL]-1 beta, @entity568 and @entity13358 ) of sciatic nerve in CCI or sham surgery @entity35 . PMF was treated on CCI @entity35 before (a day after surgery, PMF-AD) and after (a week after surgery, PMF-AW) the development of @entity158 signs. RESULTS: @entity35 exhibited @entity1931 and @entity1931 within one week following surgery, and lasted through the experiment. PMF treatments, but not SPMF, significantly enhanced the latency and threshold. Both anti- @entity1931 and anti-allodynic actions of PMF-AD were greater than those of PMF-AW treatment. Similarly, PMF-AD had more pronounced effects on the level of pro- and anti-inflammatory cytokines than did PMF-AW. CONCLUSIONS: The present findings may suggest that PMF treatment may reverse the CCI-induced changes in @entity9 behaviors by decreasing the production of pro-inflammatory cytokines and increasing the anti-inflammatory cytokine production at the site of injury.

title: Modulation of cytokine levels in ameliorative effects of pulsed magnetic field on an experimental model of XXXX .

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia', 'allodynia', 'hyperalgesic']

entities_list: @entity8638 :: ('MESH:D020208', 'Disease') :: ['Chronic Constriction Injury']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain symptoms', 'neuropathic pain']

answer: @entity8638 :: (MESH:D020208,Disease) :: ['Chronic Constriction Injury']


abstract: The authors report a 56-year-old @entity1 with @entity5528 with multiple @entity129 and @entity1576 . Five days before admission, she experienced @entity7867 and right facial @entity158 and consulted an otolaryngologist of our hospital, who diagnosed the illness as acute @entity8174 and @entity8823 . One day before admission, she experienced mild @entity1353 and general fatigue and came to our hospital emergency room. A chest X-ray film revealed no @entity4530 were observed around her right ear. The next day, her @entity1353 became more severe and she was admitted. A chest X-ray film on admission revealed right lower lobe consolidation, and neurological examination disclosed multiple @entity129 , i.e., @entity912 of the right fifth, seventh, eighth, ninth, tenth, eleventh, twelfth and @entity4775 . The serum titer of anti-herpes zoster antibody was elevated to 1,024, and the @entity1 was diagnosed as having @entity5528 with multiple @entity129 . Arterial blood gas analysis revealed @entity519 with hypercapnea, which was considered to be due to @entity1174 and central @entity1224 caused by @entity3746 . Mechanical ventilation was soon instituted and several antibiotics and @entity1033 were administered intravenously, with marked effects. Three months after admission, the @entity1 was discharged with no sequelae except mild hoarseness. @entity1 with @entity6324 , @entity3541 and auditory symptoms are diagnosed as having @entity5528 . This case was complicated by lower @entity129 and @entity1576 , which is very rare.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity5528 with multiple XXXX and @entity1576 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patients', 'woman']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve paralysis']

entities_list: @entity1033 :: ('MESH:D000212', 'Chemical') :: ['acyclovir']

entities_list: @entity8174 :: ('MESH:D010309', 'Disease') :: ['parotitis']

entities_list: @entity3746 :: ('MESH:D014826', 'Disease') :: ['vocal cord paralysis']

entities_list: @entity4530 :: ('MESH:D001768', 'Disease') :: ['abnormalities but some blisters']

entities_list: @entity5528 :: ('MESH:C535287', 'Disease') :: ['Ramsey Hunt syndrome']

entities_list: @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['acute respiratory failure']

entities_list: @entity4775 :: ('MESH:D020421', 'Disease') :: ['left tenth cranial nerve']

entities_list: @entity6324 :: ('MESH:D016697', 'Disease') :: ['herpes zoster oticus']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial nerve paralysis']

entities_list: @entity8823 :: ('MESH:D057045', 'Disease') :: ['laryngopharyngitis']

entities_list: @entity7867 :: ('MESH:D004433', 'Disease') :: ['right otalgia']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']

entities_list: @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']

answer: @entity129 :: (MESH:D003389,Disease) :: ['cranial nerve paralysis']


abstract: BACKGROUND: @entity3886 (TGA) is the most common @entity13675 , with an incidence ranging between 0.2 and 0.4 per 1000 live births. Many @entity1 not treated in the first few months of life may progress with severe @entity358 . Treatment of these @entity1 may include palliative surgery to redirect the flow at the atrial level. OBJECTIVE: Report our institutional experience with the palliative Senning procedure in @entity1 diagnosed with TGA and double outlet right ventricle with severe @entity358 , and to evaluate the early and late clinical progression of the palliative Senning procedure. METHODS: Retrospective study based on the evaluation of medical records in the period of 1991 to 2014. Only @entity1 without an indication for definitive surgical treatment of the @entity13675 due to elevated pulmonary pressure were included. RESULTS: After one year of follow-up there was a mean increase in arterial @entity26 saturation from 62.1% to 92.5% and a mean decrease in hematocrit from 49.4% to 36.3%. Lung histological analysis was feasible in 16 @entity1 . In 8 @entity1 , pulmonary biopsy grades 3 and 4 were evidenced. CONCLUSION: The palliative Senning procedure improved arterial @entity26 saturation, reduced @entity6582 , and provided a better quality of life for @entity1 with TGA with @entity1757 , severe @entity120 , and poor prognosis.

title: Palliative Senning in the Treatment of Congenital Heart Disease with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia']

entities_list: @entity13675 :: ('MESH:C536187', 'Disease') :: ['cardiopathy', 'cyanotic cardiopathy']

entities_list: @entity3886 :: ('MESH:D014188', 'Disease') :: ['Transposition of the great arteries']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defect']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vascular disease']

answer: @entity120 :: (MESH:D006976,Disease) :: ['Severe Pulmonary Hypertension']


abstract: @entity50 ( @entity50 ) is not an uncommon cause of @entity64 but very often unrecognized at initial presentation due to lack of clinical suspicion and thus frequently left untreated. @entity50 is a potentially serious condition which manifests with diverse clinical manifestations, from @entity10 to focal neurological signs and even @entity772 . @entity50 usually takes place either an inherited @entity49 or any acquired hyperviscosity state and thus prompting anticoagulation was regimen as is the cornerstone of successful treatment. We describe a 47-year-old @entity1 who presented with recurrent @entity391 in the post-operative period and later developed @entity12661 and @entity425 . Magnetic resonance imaging (MRI) showed hyperintensity involving bilateral parieto-occipital corticomedullary junction. MR venography showed signal void in the superior sagittal sinus. She was diagnosed as @entity50 and achieved complete recovery with anticoagulation therapy. @entity1188 as a consequence of @entity49 is a rare cause of @entity227 . @entity715 in the superior sagittal sinus was related to her @entity12661 and @entity425 . This case illustrates that @entity49 should be considered in cases of @entity455 leading to acute @entity1018 prompting anticoagulation therapy which can improve the outcome significantly. @entity2700 could be considered as a risk factor for development of @entity50 in appropriate situations.

title: A case of @entity49 presenting as acute reversible XXXX : a rarely reported association.

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['painless loss of vision']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['occipital vascular lesions']

entities_list: @entity2700 :: ('MESH:D003681', 'Disease') :: ['Dehydration']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['bouts of vomiting']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['thrombophilia', 'cerebral venous thrombosis']

entities_list: @entity12661 :: ('MESH:D019575', 'Disease') :: ['cortical blindness']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['asymmetric limb weakness', 'weakness']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['Bilateral occipital infarction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['Thrombosis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['isolated headache']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['Cerebral venous sinus thrombosis', 'CVST']

answer: @entity227 :: (MESH:D014786,Disease) :: ['visual loss']


abstract: The indolent @entity1893 are theoretically curable through allogeneic haematopoietic stem cell transplantation (allo-HSCT). The applicability of standard conditioning allo-HSCT is, however, restricted by its @entity137 . Recently, reduced-intensity conditioning regimens have demonstrated efficacy with significantly reduced early morbidity and mortality. We examined the safety and efficacy of rituximab-BEAM-CAMPATH as reduced-intensity conditioning for allo-HSCT in @entity706 . @entity41 was assessed by polymerase chain reaction (PCR) for @entity588 / @entity7513 translocations, and chimerism by X,Y-FISH or PCR amplification of short tandem repeat sequences. At a median follow-up of 521 days (371-719), four of five @entity1 were alive and three were in complete molecular remission. Three @entity1 required pre-emptive treatment for @entity2834 reactivation. One succumbed to a perforated viscus and one had slowly progressive disease. A graft-versus- @entity706 effect was demonstrable and quantitative PCR for @entity588 / @entity7513 may allow better accuracy in scheduling post-allograft rituximab and/or donor lymphocyte infusions. Although follow-up is short, reduced-intensity allo-HSCT with BEAM-CAMPATH conditioning appears to be safe, effective in inducing a molecular remission and is potentially curative. Further recruitment and much longer follow-up will be necessary to determine if this impacts favourably upon disease-free and overall survival.

title: Reduced-intensity rituximab-BEAM-CAMPATH allogeneic haematopoietic stem cell transplantation for XXXX is feasible and induces durable molecular remissions.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['Minimal residual disease']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'follicular lymphomas']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphomas"]

answer: @entity706 :: (MESH:D008223,Disease) :: ['follicular lymphoma']


abstract: BACKGROUND AND STUDY AIMS: @entity1 with @entity1412 ( @entity1412 ) are at increased risk for @entity5 whereas @entity14 is largely prevented by prophylactic colectomy. We analyzed the results of endoscopic surveillance and different treatment modalities of duodenal @entity11449 in @entity1 with @entity1412 . @entity1 AND METHODS: Data on endoscopies, histopathological examinations, and surgical therapies were collected from the medical histories of 129 @entity1 with @entity1412 . The cumulative incidences of duodenal @entity11449 and severe @entity1141 and @entity5 were calculated using Kaplan-Meier analysis. RESULTS: By the age of 60 years, the cumulative incidence was 80% for any @entity11449 and 23% for severe @entity1141 or @entity5 . @entity5 was observed in six @entity1 (4.7%). Fifteen endoscopic excisions in 14 @entity1 , and 19 open duodenotomies in 17 @entity1 were carried out. Later, pancreaticoduodenectomy was undertaken in six (35.3%) of these 17 @entity1 . Altogether, 12 @entity1 (9.3%) underwent pancreaticoduodenectomy. Except for one @entity1 , the indication for surgery was based on follow-up endoscopies, and none of these @entity1 died of @entity5 . No postoperative @entity204 occurred. Seven @entity1 (58.3%) had major complications, four (33.3%) of which were surgical. CONCLUSIONS: The high incidence of severe @entity1141 and @entity5 in @entity1127 suggests that endoscopic surveillance is essential. Endoscopic polypectomies under sedation anesthesia have partly replaced open duodenotomies. High-risk @entity1 with Spigelman IV @entity11449 or @entity652 with persisting severe @entity1141 should undergo surgery with pylorus-preserving pancreaticoduodenectomy before @entity3 develops.

title: Surveillance and treatment of duodenal @entity11449 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['duodenal polyps']

entities_list: @entity11449 :: ('MESH:D018255', 'Disease') :: ['adenomatosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['duodenal cancer', 'Duodenal cancer', 'cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cancer']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis', 'FAP']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity1412 :: (MESH:D011125,Disease) :: ['familial adenomatous polyposis']


abstract: OBJECTIVE: To investigate the bacteria distribution, drug bacterial sensitivity characteristics of the @entity102 ( @entity102 ). And to explore the effect of antibiotic on pathogenic bacteria culture. METHOD: Choose nasal sinus secretions from 115 @entity102 @entity1 living in rural areas. Aerobic bacteria culture, anaerobic bacteria culture and drug sensitive test were procedured for each sample. At the same time the use of antibiotics nearly 2 months and nearly 2 weeks were collected. RESULT: Among one hundred and fifteen specimens, 17 kinds of germs were detected in 37 cases, the positive rate of aerobic bacteria was 32.17%. @entity794 and epidermis @entity794 the most common type of aerobe in @entity102 @entity1 at rural areas. There was negative result in the anaerobic bacteria culture of 17 maxillary sinus specimen. The cases of using antibiotics nearly 2 months was up to 90, accounting for 78.26%. Nearly 2 weeks, 73 cases, accounting for 63.48%. The chi-square analysis showed high bacterial culture rate, in @entity102 with @entity480 (CRSwNP group), which revealed correlation between @entity2348 formation. For @entity102 @entity1 with positive result of bacterial culture, they were sensitive to @entity800 , @entity3524 , organism, @entity2177 , magnitude @entity5898 , and were drug fast to @entity3397 , @entity869 , @entity2929 . CONCLUSION: No specific differences was found in the bacteria distribution of rural @entity102 . antibiotics abusage in rural @entity102 @entity1 and the anaerobic bacteria culture techniques is the main factor resulting in low culture rate. Rational use of antimicrobial agents should be established on the basis of the bacterial culture and drug sensitive test.

title: [Secretion analysis of pathogenic bacteria culture in 115 rural chronic nasal-sinusitis XXXX ].

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'staphylococcus aureus']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection factors and nasal polyps']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic rhinosinusitis', 'rural chronic rhinosinusitis', 'CRS']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime']

entities_list: @entity5898 :: ('CHEBI:23066', 'Chemical') :: ['cephalosporin']

entities_list: @entity3397 :: ('MESH:D010400', 'Chemical') :: ['penicillin G']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin']

entities_list: @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']

entities_list: @entity800 :: ('MESH:D015242', 'Chemical') :: ['ofloxacin']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Phospholipase  C (PLC) regulates a number of cellular behaviours including cell motility, cell transformation, differentiation and cell growth. PLC plays a regulatory role in @entity5 cells partly by acting as signalling intermediates for cytokines such as EGF and interleukins. The current study examined the expression of the PLC isozymes in @entity1 @entity0 and corresponding clinical relevance. Transcript levels of @entity1 @entity44625 in @entity1 @entity0 tissues were quantitatively determined by real-time PCR. Immunochemical staining was performed for PLC-  . The clinical relevance was analysed with clinic pathological information. Mammary tissues widely expressed @entity44625 . Significantly high levels of PLC -b1 and -   were seen in @entity0 tissues in comparison with normal mammary gland tissues. PLC-y1 however, showed marginally low levels in @entity5 tissues. No significant difference was seen in the expression of the PLC isozymes in @entity5 with lymph node @entity3 . Moderately and poorly differentiated @entity0 (grade 2 and grade 3) had significantly higher levels of PLC-y1, compared with well differentiated @entity5 . High levels of PLC-   were significantly correlated with a shorter disease-free survival. The altered expression of other isozymes had no correlation with the survival. It is concluded that mammary tissues differentially expressed PLC isozymes. These isozymes have certain implications in the disease development and progression, with PLC-   showing a significant correlation with shorter disease-free survival.

title: Expression of phospholipase C isozymes in XXXX @entity0 and their clinical significance.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast tumours', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'tumour']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: To assess the presence of invasion in non-palpable @entity0 with microcalcifications. MATERIAL AND METHODS: We investigated 157 @entity1 with non-palpable @entity0 with microcalcifications, who had undergone stereotactic core biopsy or vacuum-assisted breast biopsy and operation at the @entity5 Institute Hospital between 1995 and 2001. We investigated the correlation between the area of calcification (maximum range of microcalcifications measured in mm by direct mammography), morphology of calcification on mammography, histological subtype of @entity3821 (comedo or non-comedo) and frequency of invasion, and lymph node @entity3 . The chi-square test was used in the statistical analysis and p values less than 0.05 were considered statistically significant. RESULTS: Invasion was observed in 33 of 157 pts (21%), of whom 23 showed minimal invasion, which is less than 0.5 cm in greatest diameter. The risk of invasion was 13% within 10 mm of the microcalcifications (n =70), 25% from 11 to 30 mm (n =59), and 32% more than 31 mm from the microcalcifications (n =28). The risk of invasion was 16% for punctate-round and amorphous type (n =87) microcalcifications, and 27% for @entity1893 (n =70)(p =0.092). In addition, invasion was found 10% of the time within 10 mm of punctate-round and amorphous @entity164 , and 20% of the time at 11 mm or more. On the other hand, invasion was found 15% of the time within 10 mm of @entity1893 , and 37% of the time at 11 mm or more. In 72 cases of @entity3821 diagnosed by pathological examination, invasion was found in 10 of 31 (32%) @entity3821 and in 5 of 41 (12%) non-comedo types (p =0.0379). There were 5 cases (3.2%) with axillary lymph node @entity3 , all of which widely extended more than 21 mm from the microcalcifications. CONCLUSION: The risk of invasion was 10% within 10 mm of punctate-round and amorphous @entity164 , and 37% at more than 11 mm of @entity1893 .

title: What is the predictor for invasion in non-palpable XXXX with microcalcifications?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3821 :: ('MESH:D002285', 'Disease') :: ['comedo type intraductal carcinomas', 'intraductal carcinoma']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity164 :: ('MESH:D017827', 'Disease') :: ['type microcalcifications']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['pleomorphic and linear-branching types', 'pleomorphic and linear-branching type microcalcifications', 'pleomorphic, linear-branching microcalcifications']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: PURPOSE: To evaluate the efficacy of adding nepafenac 0.1% ophthalmic suspension to @entity619 0.1% eyedrops in controlling macular swelling and other manifestations of @entity32 after uneventful @entity231 surgery. SETTING: Ophthalmology Department, M  lndal Hospital, Gothenburg, and St. Erik Eye Hospital, Stockholm, Sweden. DESIGN: Randomized double-masked clinical trial. METHODS: @entity1 at low risk for @entity86 were recruited and randomized to the nepafenac group or to the control group. Postoperative swelling of the macula was assessed with ocular coherence tomography. Laser flare intensity, corrected distance visual acuity, @entity227 were also recorded. RESULTS: The analysis of intent-to-treat population comprised 75 @entity1 in the nepafenac group and 77 @entity1 in the control group. Compared with the control regimen, add-on nepafenac resulted in statistically significant reductions in the following parameters: change in macular volume at 3 weeks and 6 weeks (P<.001), proportion of @entity1 with more than 10  m of swelling in the central macula at 3 weeks (P<.0001) and 6 weeks (P=.02), mean laser flare intensity at 1 day (P=.029), @entity158 during the first 24 hours postoperatively (P<.0001), and @entity2194 and @entity3917 during the first 3 postoperative weeks (P=.0058 and P=.0052, respectively). CONCLUSION: The combination of topical nepafenac and @entity134 treatment reduced subclinical macular swelling and @entity32 as well as subjective complaints, indicating it is an efficient antiinflammatory regimen after @entity231 surgery. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Nepafenac 0.1% plus @entity619 0.1% versus @entity619 alone: effect on macular swelling after XXXX surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['ocular discomfort, and visual complaints']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular discomfort']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative inflammation']

entities_list: @entity3917 :: ('MESH:D020795', 'Disease') :: ['photophobia']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: The @entity482 (MC) presents as lesions restricted solely to the skin. The poxvirus @entity31382 (MCV) is responsible for this @entity272 that is easily transmitted through casual contact amongst all populations with greater frequency in @entity1 and immunosuppressed individuals. In addition, sexual transmission of MCV in adolescents and adults is a health concern. Although the @entity272 ultimately resolve in immune competent individuals, they can persist for extended times and be @entity158 and result in scarring. Treatment is problematic and there is no drug that specifically targets MCV. The inability of MCV to propagate in cell culture has impeded drug development. To overcome these barriers, we integrated three new developments. First, we have identified a new MCV drug target ( @entity64698 ) that is essential for processive DNA synthesis in vitro. Second, we have discovered a small chemical compound that binds to @entity64698 and prevents DNA synthesis in vitro. Third, and most significantly, we have engineered a hybrid @entity6621 ( @entity64698 -VV) in which the natural vaccinia vD4 gene is replaced by the @entity64698 target gene. This hybrid virus is dependent on @entity64698 for viral growth in culture and is inhibited by the small compound. This target system provides for the first time a platform and approach for the discovery and evaluation of new therapeutics that can be used to treat MC.

title: A Novel Target and Approach for Identifying Antivirals against XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity482 :: ('MESH:D008976', 'Disease') :: ['dermatological disease molluscum contagiosum']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease', 'skin lesions']

entities_list: @entity31382 :: ('10279', 'Species') :: ['molluscum contagiosum virus']

entities_list: @entity6621 :: ('10245', 'Species') :: ['vaccinia virus']

answer: @entity31382 :: (10279,Species) :: ['Molluscum Contagiosum Virus']


abstract: OBJECTIVE: The influence of backrest support and handgrip contractions on acute metabolic, respiratory, and cardiovascular responses were evaluated in 13 healthy @entity1 during exposure to whole-body vibration (WBV). METHODS: Following assessment of aerobic fitness during arm cranking, subjects were exposed to frequencies 3, 4.5, and 6 Hz with 0.9 g(r.m.s) acceleration magnitude on a vibrating base in randomized order, on separate days. Each exposure included 6 min baseline without WBV, 8 min of WBV exposure either 'with' or 'without' backrest, 4 min recovery, followed by 8 min of WBV with opposite backrest condition, and 4 min recovery. During the final minute of WBV, subjects performed right hand maximal @entity2472 for one minute. During baseline and before completion of WBV session 'with' and 'without' backrest, cardiac output was estimated indirectly by @entity544 rebreathing. RESULTS: At 3 and 4.5, and 3 and 6 Hz, absolute and relative @entity26 uptake demonstrated significantly greater responses during sitting 'without' backrest than 'with' backrest (P<0.01). At 3 and 4.5 Hz, heart rate and @entity26 pulse responses were significantly greater during WBV combined with handgrip contractions than during WBV alone (P<0.01), demonstrating physical work during WBV will enhance greater metabolic responses. @entity64 volume was the lowest at 4.5 Hz (P<0.01). Influence of aerobic fitness was evident only in absolute @entity26 uptake, @entity26 pulse, and ventilation volume (P<0.01). CONCLUSIONS: This study demonstrates that subjects exposed to physical work during WBV will experience greater metabolic responses compared to WBV alone, and the physiological responses during WBV resemble to that of a light physical work. Despite low metabolic rates during WBV, the effect of aerobic fitness suggests the importance of physical activity in occupations exposed to WBV.

title: Acute physiological responses in healthy XXXX during whole-body vibration.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['rhythmic handgrip contractions']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: @entity697 remains a life-threatening complication of @entity253 , particularly in the elderly with comorbid disease or when there is a delay in diagnosis and treatment. The initial management consists of fluid resuscitation, correction of @entity1003 , and administration of broad-spectrum antibiotics. The choice of antibiotics should cover both gram-negative and gram-positive organisms associated with @entity255 until the results of a blood culture are available. The timing and choice of biliary decompression varies depending on the response to antibiotic therapy, the presence of comorbid disease, and the underlying cause. @entity253 in most @entity1 with conservative treatment, thus allowing time to perform more detailed non-interventional imaging (e.g., spiral computed tomography [CT], magnetic resonance cholangiopancreatography [MRCP]) to determine the underlying cause and level of @entity253 . Those with @entity255 who do not respond to conservative therapy will require urgent biliary decompression. In @entity1 with @entity2877 , endoscopic drainage is now the treatment of choice or, if this fails, transhepatic biliary decompression is a useful alternative. Various endoscopic options are available for managing @entity2877 , ranging from endoscopic papillotomy (EP) and extraction of stones, to the placement of a biliary drainage system. In @entity1 who respond to antibiotic therapy, EP with stone extraction is preferred, while in those with @entity295 and multiple large stones, the placement of a stent with or without an EP is the safest option. Transhepatic biliary drainage is now reserved for failure of endoscopic drainage and for @entity1 with suspected @entity201 or intrahepatic stones. Surgical biliary decompression is seldom required in the emergency setting, but still plays an important role in the definitive treatment of the underlying cause.

title: Management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['Acute cholangitis']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['ongoing sepsis']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['hilar cholangiocarcinoma']

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary obstruction', 'Biliary sepsis resolves']

entities_list: @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis']

entities_list: @entity2877 :: ('MESH:D042883', 'Disease') :: ['choledocholithiasis']

answer: @entity255 :: (MESH:D002761,Disease) :: ['cholangitis']


abstract: OBJECTIVE: To describe the early and late outcomes of uterine smooth @entity11090 that are either malignant or have the potential for recurrence (MRUSMTs) after uterine artery embolization (UAE). DESIGN: Literature review of MRUSMTs in case reports and in studies on @entity1 outcome after UAE and reports of one case of @entity1822 ( @entity1822 ) and 2 cases of @entity2909 ( @entity2909 ) after UAE. SETTING: University hospital. INTERVENTION(S): Main outcome measure(s) and clinical outcome of UAE and prevalence of MRUSMT. RESULT(S): In the review of clinical trials, six cases of @entity242 were reported after UAE treatment in 8084 procedures. One of the six @entity242 cases and one case of @entity20866 occurred more than two years after the UAE. Thirteen cases of @entity1822 , two cases of @entity2909 and no cases of MRUSMTs after UAE were identified in the published case reports. Six of the thirteen @entity1 with @entity242 exhibited a good initial clinical response, but their symptoms relapsed after six months. UAE had a failed outcome in the two @entity2909 cases. CONCLUSION(S): MRUSMTs are rarely treated using UAE; late malignant transformation is infrequent but may be underreported. UAE treatment of @entity1822 does not seem to spread the disease, but this approach may impair prognosis by delaying diagnosis. @entity5 with low malignant potential may initially exhibit @entity353 and a good clinical response, but these @entity5 may exhibit persistent enhancement with contrast-enhanced magnetic resonance imaging (MRI). Special attention is required in cases with or without a limited response to UAE.

title: Literature review of outcomes and prevalence and case report of @entity1822 and non-typical uterine smooth muscle XXXX treated with uterine artery embolization.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity20866 :: ('MESH:D018231', 'Disease') :: ['intravenous leiomyomatosis']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['volume reduction']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'tumors']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['leiomyosarcoma', 'leiomyosarcomas', 'LMS']

entities_list: @entity11090 :: ('MESH:D019042', 'Disease') :: ['muscle tumors']

entities_list: @entity2909 :: ('MESH:D007889', 'Disease') :: ['bizarre leiomyoma', 'BL']

answer: @entity5 :: (MESH:D009369,Disease) :: ['leiomyoma tumors']


abstract: BACKGROUND: @entity43 are a group of @entity5 that have diverse spectrum of features according to the particular @entity5 entity. @entity43 is the leading cause of death in females. The aim of this study is to determine the frequency of @entity43 and its distribution according to cell of origin and age group. MATERIAL AND METHOD: This is a retrospective study of all cases of @entity43 collected during a period of 9 years from the Histopathology Department of Al-Gamhuria Teaching Hospital from 1993-1996 and Ibn Sina laboratory in Aden Governorate from 2009- 2013. RESULTS: The @entity5 are grouped according to the nature of @entity5 whether benign, borderline or malignant, and according to cell of origin and age group. @entity5 are the most frequent (86.7%), and malignant are less (13.3%). The total surface @entity5 are 63.7%, @entity5 are the most common (44%), followed by mucinous t mors (9.6%), serous tadenocarcinoma (2.8%), @entity4347 (1.8%), @entity12679 (1.4%), and @entity4348 (1.4%). The least frequent @entity5 are @entity8940 borderline and poorly differentiated @entity189 at 0.9% each. @entity5 derived from sex cord stromal tissue as benign @entity81 and @entity17815 comprise 5%, while @entity5 are @entity722 (1.4%) and androblast ma moderately differentiated (0.5%). @entity5 derived from germ cell as benign cystic @entity44 are 26.6% while @entity5 were @entity5000 (0.9%) and malignant @entity44 (0.5%). CONCLUSION: @entity5 outnumber the @entity5 . Surface @entity5 are the most common class of @entity5 . @entity5 are not frequent. The high death rates are due to advanced @entity5 during the time of diagnosis from the majority of cases.

title: Spectrum of XXXX : Histopathological study of 218 cases.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Ovarian cancer', 'ovarian tumors', 'Ovarian tumors']

entities_list: @entity722 :: ('MESH:D006106', 'Disease') :: ['granulosa cell tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['benign serous tumors', 'epithelial tumors', 'neoplasms', 'tumor', 'tumors', 'Tumors', 'malignant tumors', 'Benign tumors', 'Bilateral tumors', 'malignancy']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

entities_list: @entity5000 :: ('MESH:D004407', 'Disease') :: ['dysgerminoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity4347 :: ('MESH:D018282', 'Disease') :: ['mucinous cystadenocarcinoma']

entities_list: @entity8940 :: ('MESH:D018291', 'Disease') :: ['mucinous cystadenoma']

entities_list: @entity81 :: ('MESH:D005350', 'Disease') :: ['fibroma']

entities_list: @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid adenocarcinoma']

entities_list: @entity12679 :: ('MESH:D018293', 'Disease') :: ['serous cystadenoma borderline']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian tumors']


abstract: PURPOSE: To test the feasibility of velocity distribution analysis for identifying altered three-dimensional (3D) flow characteristics in @entity1 with @entity2333 based on 4D flow MRI volumetric analysis. METHODS: Forty @entity1 with aortic (Ao) dilation (mid ascending aortic diameter MAA   =   40        7 mm, age   =   56        17 years, 11 females) underwent cardiovascular MRI. Four groups were retrospectively defined: mild @entity384 (n   =   10; MAA   <   35 mm); moderate @entity384 (n   =   10; 35   <   MAA   <   45 mm); severe @entity384 (n   =   10; MAA   >   45 mm); @entity384 +aortic stenosis @entity5427 (n   =   10; @entity11596   >   35 mm and peak velocity   >   2.5 m/s). The 3D PC-MR angiograms were computed and used to obtain a 3D segmentation of the aorta which was divided into four segments: root, ascending aorta, arch, descending aorta. Radial chart displays were used to visualize multiple parameters representing segmental changes in the 3D velocity distribution associated with @entity2333 . RESULTS: Changes in the velocity field and geometry between cohorts resulted in distinct hemodynamic patterns for each aortic segment. Disease progression from mild to @entity384   +   @entity5427 resulted in significant differences (P   <   0.05) in flow parameters across cohorts and increased radial chart size for root and ascending aorta segments by 146% and 99%, respectively. CONCLUSION: Volumetric 4D velocity distribution analysis has the potential to identify characteristic changes in regional blood flow patterns in @entity1 with @entity2333 . Magn Reson Med 74:817-825, 2015.    2014 Wiley Periodicals, Inc.

title: Assessment of altered three-dimensional blood characteristics in XXXX by velocity distribution analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['Ao dilation']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic disease']

answer: @entity2333 :: (MESH:D001018,Disease) :: ['aortic disease']


abstract: The aim of the current study was to evaluate the influence of platelet-derived growth factor (PDGF) on skin microcirculation during normal and @entity73 . @entity130 were created on the ears of hairless @entity19 and treated once with 3 microg of PDGF-BB immediately after wound creation. Intravital fluorescence microscopy was used to quantify reepithelialization, revascularization, vessel diameters, vascular permeability, and leukocyte-endothelium interactions up to 24 days after wound creation. Microvascular perfusion was assessed by laser Doppler flowmetry. Wound healing was studied in normal (n = 15) and @entity63 skin tissue (n = 15) as well as in @entity19 (n = 17) rendered @entity1602 by an intravenous injection of @entity3839 7 days prior to wound creation. Treatment with PDGF accelerated reepithelialization and reduced the time for complete wound closure in @entity63 skin from 14.9 +/- 2.5 (control) to 12.3 +/- 1.8 days (p < 0.03), and in @entity1602 animals from 15.0 +/- 2.4 (control) to 12.0 +/- 3.0 days (p < 0.04). Revascularization of these wounds was also significantly enhanced after PDFG application. No other parameters were influenced by the treatment. Normal wound healing was not affected. This study confirms the positive influence of PDGF on wound healing under pathophysiological conditions. The effects in this model seem to be primarily due to the mitogenic potency of PDGF on keratinocytes and endothelial cells. A significant effect on leukocyte activation during the inflammatory process was not observed.

title: Influence of platelet-derived growth factor on microcirculation during normal and XXXX .

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired wound healing']

entities_list: @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Secondary healing wounds']

answer: @entity73 :: (MESH:D003072,Disease) :: ['impaired wound healing']


abstract: A kinetic analysis of @entity1507 denitrification by a single or two species of denitrifying bacteria with @entity413 or @entity1068 as a @entity505 source and @entity3542 or @entity3810 as intermediate products was performed using experimental data published earlier (Menyailo and Hungate, 2006; Vidal-Gavilan et al., 2013). Modified Monod kinetics was used in the dynamic biological model. The special equations were added to the common dynamic biological model to describe how isotopic fractionation between N species changes. In contrast to the generally assumed first-order kinetics, in this paper, the traditional Rayleigh equation describing stable @entity1568 and @entity26 isotope fractionation in @entity1507 was derived from the dynamic isotopic equations for any type of kinetics. In accordance with the model, in Vidal-Gavilan's experiments, the maximum specific rate of @entity1507 reduction was proved to be less for @entity1068 compared to @entity413 . Conversely, the maximum specific rate of @entity3542 reduction was proved to be much less for @entity413 compared to @entity1068 . Thus, the intermediate @entity3542 concentration was negligible for the @entity1068 experiment, while it was significant for the @entity413 experiment. In Menyailo's and Hungate's experiments, the low value of maximum specific rate of @entity3810 reduction gives high intermediate value of @entity3810 concentration. The model showed that the dynamics of @entity1568 and @entity26 isotope signatures are responding to the biological dynamics. Two microbial species instead of single denitrifying bacteria are proved to be more adequate to describe the total process of @entity1507 denitrification to @entity24471 .

title: XXXX denitrification with @entity3542 or @entity3810 as intermediate products: Stoichiometry, kinetics and dynamics of stable isotope signatures.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity24471 :: ('CHEBI:17997', 'Chemical') :: ['dinitrogen']

answer: @entity1507 :: (CHEBI:48107,Chemical) :: ['Nitrate']


abstract: OBJECTIVE: To compare the safety and estimate the response profile of @entity1037 , a second-generation antipsychotic, to @entity1767 in the treatment of @entity933 in the critical care setting. DESIGN: Prospective randomized trial. SETTING: Tertiary care university affiliated critical care unit. @entity1 : All admissions to a medical and surgical intensive care unit with a diagnosis of @entity933 . INTERVENTIONS: @entity1 were randomized to receive either enteral @entity1037 or @entity1767 . MEASUREMENTS: @entity1 's @entity933 severity and @entity1245 use were monitored over 5 days after the diagnosis of @entity933 . MAIN RESULTS: Delirium Index decreased over time in both groups, as did the administered dose of @entity1245 . Clinical improvement was similar in both treatment arms. No side effects were noted in the @entity1037 group, whereas the use of @entity1767 was associated with extrapyramidal side effects. CONCLUSIONS: @entity1037 is a safe alternative to @entity1767 in delirious critical care @entity1 , and may be of particular interest in @entity1 in whom @entity1767 is contraindicated.

title: @entity1037 vs @entity1767 : treating XXXX in a critical care setting.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS', 'Patient']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine', 'benzodiazepines']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

entities_list: @entity1037 :: ('MESH:C076029', 'Chemical') :: ['Olanzapine', 'olanzapine']

answer: @entity933 :: (MESH:D003693,Disease) :: ['delirium']


abstract: BACKGROUND: There is an increasing trend in the prevalence of @entity453 ( @entity453 ) in Iran. OBJECTIVES: The present study aimed to investigate the relationship of @entity148 , @entity308 , @entity6 and @entity453 among @entity1 undergoing angiography in Ghaem Hospital, Mashhad, Iran. @entity1 AND METHODS: This case-control study was conducted between September 2011 and August 2012 among 200 @entity1 undergoing coronary angiography for symptoms of @entity301 at Ghaem Hospital, Mashhad, Iran. The control group consisted of 697 healthy adults recruited from the individuals who attended the clinic for routine medical checkups or pre-employment examinations. The Beck @entity148 and @entity308 inventory scores and fasting @entity13897 results were assessed in all the subjects. Data were analyzed using SPSS version 16. P < 0.05 was regarded as statistically significant. RESULTS: The mean age of @entity1 was 57.52    9.33 years old and for the control group it was 55.35    8.45 years; there was no significant difference between the subjects (P = 0.647) regarding age. There was also no significant difference in gender distribution between the @entity1 and control groups (P = 0.205). There was however a significant difference in @entity148 and @entity308 scores between the @entity1 and healthy controls (P < 0.001). There was a significant positive correlation between @entity148 score and @entity308 score in both groups when data were analyzed by Pearson test. (P < 0.001, r = 0.604 and r = 0.521). Moreover, there was a significant positive linear correlation between the @entity308 / @entity148 scores and fasting @entity13897 concentrations in the @entity1 group (r = 0.3, P < 0.001) and a weak negative correlation in the healthy controls (r = -0.096, P < 0.05). CONCLUSIONS: @entity308 and @entity148 are potentially important factors among @entity1 with angiographically-defined @entity453 . There appear to be significant associations between glucose tolerance and @entity148 and @entity308 in these @entity1 .

title: XXXX , @entity308 , @entity453 and @entity6 ; an association study in ghaem hospital, iran.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity13897 :: ('MESH:D018149', 'Disease') :: ['blood glucose']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety']


abstract: Angiogenic cytokines in the plasma and serum of @entity5 @entity1 may serve as 'surrogate' markers of @entity5 neoangiogenesis. Serum @entity7 correlates with disease stage in @entity14 ( @entity14 ), but the role of @entity540 in @entity14 is uncertain. This study aimed to assess plasma @entity540 levels in @entity14 @entity1 before treatment, during chemoradiotherapy and at one-year follow-up. Plasma samples were taken from 124 @entity14 @entity1 , 26 @entity1127 @entity1 and 55 controls, and @entity540 levels were measured by ELISA. 19 @entity1 underwent pre-operative chemoradiotherapy. One-year follow-up samples were available from 48 disease-free @entity1 and 18 @entity1 with @entity74 . There were no detectable differences between plasma @entity540 levels in @entity1127 , Dukes' A or B @entity1 (4.55, 5.77, 4.25 pg/ml, respectively), but there was a significant increase in metastatic @entity14 @entity1 [Dukes' C and D (7.42 and 6.6 pg/ml; P = 0.004 and 0.048, respectively)], relative to median control levels of 4.14 pg/ml. At follow-up, there was a significant fall in plasma @entity540 levels in disease-free @entity1 (pre-op 6.09 and follow-up 3.45 pg/ml, P = 0.0004), but a non-significant rise in 18 @entity1 with @entity74 (pre-treatment 5.90 and follow-up 9.99 pg/ml, P = 0.33). Pre-treatment plasma @entity540 in @entity1 receiving chemo-radiotherapy was similar in those with responsive and @entity5 . There were no detectable changes in plasma @entity540 through the @entity2513 sequence or @entity1 groups with non-metastatic @entity5 . Elevated plasma @entity540 was, however, associated with metastatic spread. The significant fall in @entity540 in disease-free @entity1 following therapy suggests that @entity540 may be useful in clinical practice.

title: Plasma basic fibroblast growth factor levels in XXXX : a clinically useful assay?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'non-responsive tumours', 'tumour']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive disease']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma-carcinoma']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: STATEMENT OF PROBLEM: Psychological and behavioral traits may be important for the diagnosis and management of @entity158 . PURPOSE: This study compared the levels of @entity308 and @entity2531 in @entity1 in single and multiple research diagnostic criteria for @entity2956 ( @entity20683 / @entity9321 ) diagnostic groups. MATERIAL AND METHODS: The @entity20683 / @entity9321 was established to allow standardization and replication of research into the most common forms of muscle- and joint-related research and is divided into 2 axes: axis I, clinical @entity9321 , and @entity2270 , @entity158 and psychological status. One hundred seventeen @entity1 (28 male and 89 female; mean age, 33.3 +/- 10.3 years) with @entity20683 / @entity9321 -defined clinical @entity9321 were selected. The @entity20683 / @entity9321 history questionnaire and examination forms were input directly into computers with the use of a software program developed at the National University of Singapore (NUS TMDv1.1 software). @entity2270 and II variables were generated online and automatically archived for statistical analysis. @entity1 were subsequently classified into 7 groups based on the presence of the various @entity20683 / @entity9321 axis I diagnostic groups: group A, @entity158 only (group I); group B, disk displacement only (group II); group C, other joint conditions such as @entity4841 , @entity571 , and @entity571 only (group III); group D, @entity158 and disk displacement (groups I and II); group E, @entity158 and other joint conditions (groups I and III); group F, disk displacement and other joint conditions (groups II and III); and group G, @entity158 , disk displacement, and other joint conditions (groups I, II, and III). Differences in mean Symptom Checklist-90 scores between groups were compared by analysis of variance/Scheff   tests to contrast @entity308 and @entity2531 levels between the various axis I diagnostic groups (alpha=.05). RESULTS: The frequencies of the different groups were as follows: group A, 26.5%; group B, 29.9%; group C, 12.8%; group D, 6.0%; group E, 13.7%; group F, 4.3%; and group G, 6.8%. Approximately 39% of @entity1 were clinically depressed, and 55% had moderate to severe @entity2531 . Differences in mean @entity308 and @entity2531 with @entity158 item scores were significant between groups (P<.05). CONCLUSION: Within the limitations of this study, @entity1 diagnosed with @entity158 and other joint conditions (group E) had significantly higher levels of @entity308 (P=.03) and @entity2531 (P=.03) than @entity1 diagnosed with only disk displacements (group B).

title: XXXX and @entity2531 in @entity1 with @entity2956 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthrosis', 'osteoarthritis']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['temporomandibular disorders']

entities_list: @entity2531 :: ('MESH:D013001', 'Disease') :: ['somatization']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain-related disability', 'myofascial pain', 'orofacial pain', 'pain']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: PURPOSE: We investigated whether the European Organization for Research and Treatment of @entity5 (EORTC) scoring system can be used for the selection of adjuvant intravesical therapies for individual @entity1 who undergo transurethral resection (TURB) for non-muscle-invasive @entity150 (NMIBC). METHODS: We retrospectively analyzed the data of 469 TURB cases for NMIBC. Clinical and pathological variables were compared using univariate and multivariate Cox proportional hazards regression analyses. The @entity1349 ( @entity1349 ) rate was estimated by the Kaplan-Meier method, and the log-rank test was used to compare groups divided according to EORTC score or type of adjuvant therapy. RESULTS: The overall @entity1349 rate at 1 and 3  years was 59.1 and 40.3  %, respectively. Of the total, 424 TURB cases (90.4  %) had an EORTC score of 1-9. @entity5 number, size, and grade were significant predictors of time to recurrence. The EORTC score was a significant predictor of @entity1349 according to multivariate analysis, and the hazard ratios increased according to each EORTC score in multivariate analysis of a combination of EORTC score and adjuvant therapies. In groups with intermediate recurrence risk as defined by the European Association of Urology guidelines, the recurrence prevention effects in @entity1 with an EORTC score of >= 5 were significantly greater with intravesical Bacillus Calmette-Gu  rin therapy than with weekly intravesical chemotherapy. CONCLUSION: The EORTC scoring system provides useful information for the selection of adjuvant therapies for @entity1 at intermediate risk of NMIBC recurrence.

title: Selection of adjuvant intravesical therapies using the European Organization for Research and Treatment of @entity5 scoring system in @entity1 at intermediate risk of non-muscle-invasive XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumor', 'Cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['RFS', 'recurrence-free survival']

answer: @entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']


abstract: BACKGROUND: Emerging evidence suggests that, contrary to standard teaching, isolated @entity1545 may be associated with @entity551 . This study sought to determine the frequency of isolated @entity1545 -induced @entity551 in @entity130 victims. METHODS: @entity551 adult @entity130 @entity1 were categorized according to the cause of @entity551 : @entity548 (hemoglobin < 11.0), neurogenic, isolated brain, or other. Their clinical data and outcomes were compared. RESULTS: The cause of @entity551 was @entity548 in 113 (49%), isolated @entity1545 in 30 (13%), neurogenic in 14 (6%), and other causes in 24 (10%). Fifty (22%) were indeterminate. @entity548 , isolated brain, and neurogenic groups were similar in age, Injury Severity Score, and systolic blood pressure. The Glasgow Coma Scale score of the isolated brain group was lower than in the @entity548 group (4.4 vs. 8.4, p < 0.05). Mortality was higher in the isolated brain group compared with the @entity548 group (80% vs. 50%, p < 0.05) and in the subgroup of @entity548 @entity1 with versus without associated @entity1545 (57% vs. 39%, p < 0.05). CONCLUSION: Isolated @entity1545 account for 13% of @entity551 events after @entity130 and are associated with an increased mortality compared with @entity548 -induced @entity551 . In @entity551 brain-injured @entity1 , @entity548 sources should be excluded rapidly, and the focus should be on resuscitation.

title: Isolated @entity1545 as a cause of @entity551 in the XXXX @entity1 .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injuries', 'brain injury']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic', 'hemorrhage', 'Hemorrhagic']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive', 'Hypotensive', 'hypotension']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['blunt trauma']