abstract: @entity1146 and @entity849 with intact ventricular septum includes a wide spectrum of @entity13675 with great morphological heterogeneity. The @entity338 may be completely atretic or may contain a puncture hole if @entity850 is present. The obstruction may be membranous and/or muscular. All components of the right ventricle can be affected, even the coronary circulation with ventriculocoronary connections and @entity850 or @entity1146 of the pulmonary arteries. Prenatal diagnosis is made when the right ventricle is hypoplastic and @entity1184 . The @entity338 is thickened and the pulmonary artery is perfused retrogradely through the ductus arteriosus. Right ventriculocoronary connections may sometimes be seen with fetal echocardiography. Postnatal survival depends on the @entity2461 , requiring @entity5015 infusion. When hypoplastic right ventricle and/or ventricle-dependent coronary circulation exists, biventricular circulation is not possible. In these cases, surgical treatment is palliative. In cases with well-developed right ventricle, transcatheter therapy is usually provided with perforation and balloon dilation of the @entity338 . In cases of @entity3986 of the right ventricle outflow tract, surgery may be considered as first-line therapy. In case of prenatal diagnosis, the medical termination of pregnancy is possible when severe @entity4265 exists, precluding biventricular circulation. Postnatally, the prognosis of the @entity1 is highly variable, mainly related to the size of the right cavities and the presence of @entity301 .

title: [ @entity849 and XXXX with intact ventricular septum].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity13675 :: ('MESH:C536187', 'Disease') :: ['cardiopathies']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary anomalies']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['muscular obstruction']

entities_list: @entity2461 :: ('MESH:D004374', 'Disease') :: ['patency of the ductus arteriosus']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['pulmonary valve']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['critical pulmonary stenosis']

entities_list: @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1']

entities_list: @entity1146 :: ('MESH:D018633', 'Disease') :: ['Pulmonary atresia', 'atresia']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity4265 :: ('MESH:C535682', 'Disease') :: ['right ventricular hypoplasia']

answer: @entity1146 :: (MESH:D018633,Disease) :: ['atresia']


abstract: Abandoned mine areas, used in the past for the extraction of minerals, constitute a degraded landscape which needs to be reintegrated to productive or leisure activities. However these soils, mainly composed by silt or sand and with low organic matter content, are vulnerable to organic and inorganic pollutants posing a risk to the surrounding ecosystems and groundwater. Soils from two mining areas from Andalusia were evaluated: one from Nerva (NCL) in the Iberian Pyrite Belt (SW Andalusia) and another one from the @entity68 Alquife mine (ALQ) (SE Andalusia). To improve soil properties and fertility two amendments, stabilised sewage sludge (SSL) and composted sewage sludge (CSL), were selected. The effect of amendment addition on the mobility of two model pesticides, @entity41100 and @entity58170 , was assessed using soil columns under non-equilibrium conditions. @entity58170 , more hydrophobic than @entity41100 , only leached from native ALQ, a soil with lower organic @entity505 (OC) content than NCL (0.21 and 1.4%, respectively). Addition of amendments affected differently pesticide mobility: @entity41100 in the leachates was reduced by 14% in NCL-SSL and by 4% in ALQ-CSL. Soil OC and dissolved OC were the parameters which explained pesticide residues in soil. Chemical analysis revealed that leachates from the different soil columns did not contain toxic element levels, except As in NCL soil. Finally ecotoxicological data showed moderate @entity137 in the initial leachates, with an increase coinciding with pesticide maximum concentration. The addition of SSL slightly reduced the @entity137 towards @entity7866 , likely due to enhanced retention of pesticides by amended soils.

title: Pesticide mobility and leachate XXXX in two abandoned mine soils. Effect of organic amendments.

entities_list: @entity41100 :: ('MESH:C417209', 'Chemical') :: ['thiacloprid']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity7866 :: ('668', 'Species') :: ['Vibrio fischeri']

entities_list: @entity58170 :: ('MESH:C033789', 'Chemical') :: ['fenarimol', 'Fenarimol']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: Rapid advances in radiologic technology and increased cross-sectional imaging have led to a sharp rise in incidental discoveries of @entity660 . These @entity5409 include non-neoplastic cysts with no risk of @entity5 , neoplastic non-mucinous @entity12679 with little or no risk of @entity5 , as well as @entity5 and solid @entity5 both with varying risk of @entity5 . Accurate diagnosis is imperative as management is guided by symptoms and risk of @entity5 . Endoscopic ultrasound (EUS) allows high resolution evaluation of cyst morphology and precise guidance for fine needle aspiration (FNA) of cyst fluid for cytological, chemical and molecular analysis. Initially, clinical evaluation and radiologic imaging, preferably with magnetic resonance imaging of the pancreas and magnetic resonance cholangiopancreatography, are performed. In asymptomatic @entity1 where diagnosis is unclear and malignant risk is indeterminate, EUS-FNA should be used to confirm the presence or absence of high-risk features, differentiate mucinous from non-mucinous lesions, and diagnose @entity5 . After analyzing the cyst fluid for viscosity, cyst fluid carcinoembryonic antigen, amylase, and cyst wall cytology should be obtained. DNA analysis may add useful information in diagnosing @entity45 when the previous studies are indeterminate. New molecular biomarkers are being investigated to improve diagnostic capabilities and management decisions in these challenging @entity5409 . Current guidelines recommend surgical pancreatic resection as the standard of care for symptomatic cysts and those with high-risk features associated with @entity5 . EUS-guided cyst ablation is a promising minimally invasive, relatively low-risk alternative to both surgery and surveillance.

title: Endosonography in the diagnosis and management of XXXX .

entities_list: @entity5409 :: ('MESH:D052177', 'Disease') :: ['cystic lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic mucinous cysts', 'pseudopapillary neoplasms', 'malignancy']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic cystic lesions']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['mucinous cysts']

entities_list: @entity12679 :: ('MESH:D018293', 'Disease') :: ['serous cystadenomas']

answer: @entity45 :: (MESH:D010181,Disease) :: ['pancreatic cysts']


abstract: UNASSIGNED: There are few beneficial management practices (BMPs) with demonstrated efficacy in snowmelt-dominated regions. Small reservoirs are a BMP that can help mitigate flooding and reduce sediment transport, while reducing export of dissolved nutrients. To understand controls on @entity1507 removal and assess how this ecosystem service can be optimized, denitrification activity was measured in reservoirs and stream pools of the @entity286 Creek Model Watershed (Manitoba, Canada) via the @entity2755 -amended @entity14493 block technique. Denitrification activity was positively correlated with @entity1507 and sediment organic @entity505 (SOC), and negatively correlated with sediment particle size and pH. Reservoirs exhibited higher denitrification activity than stream pools and were associated with higher levels of SOC, higher @entity1507 in early summer, and lower concentrations of dissolved @entity26 . @entity1507 was added to a set of samples to test for @entity1507 saturation, an indicator of poor ecological status, where @entity1507 concentrations exceed the denitrification capacity of microbes. Forty-nine percent of measurements demonstrated @entity1507 saturation, indicative of the need for additional remediation activity. Findings from this research suggest this BMP has higher capacity for @entity1568 removal than stream pools because of higher denitrification rates and a higher apparent threshold for @entity1507 saturation, coupled with increased residence times. Results also inform the construction of additional reservoirs, which have been identified as a priority BMP in this region. Siting reservoirs in areas where conditions contribute to buildup of fine sediments and planting @entity47 to foster high organic C availability may help optimize denitrification, although tradeoffs in terms of other ecosystem services must be considered.

title: Small Reservoirs as a Beneficial Management Practice for XXXX Removal.

entities_list: @entity14493 :: ('MESH:D000114', 'Chemical') :: ['acetylene']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['Nitrate', 'nitrate']

entities_list: @entity47 :: ('MESH:D018458', 'Disease') :: ['riparian vegetation']

entities_list: @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol']

answer: @entity1568 :: (MESH:D009584,Chemical) :: ['Nitrogen']


abstract: OBJECTIVE: @entity1255 ( @entity5784 ) is a relevant biomarker of @entity455 : serum @entity5784 concentrations will increase the risk of @entity101 , whereas @entity3562 ( @entity3562 ) has a synergistic effect with @entity101 and increases the risk of @entity65 . However, information has primarily been gathered from high-income and urban settings, and little is known regarding low-income rural settings. This study focused on a low-income rural and nomadic minority residing in far western China. @entity5784 levels were tested, and the prevalences of @entity3562 and @entity8108 -type @entity101 were investigated in this population. METHODS: This study used a stratified cluster random sampling method, selecting 2,180 individuals as subjects from Kazakh and Uyghur inhabitants (>= 25 years old) of 18 villages in Xinjiang, China, which is approximately 4407 km from the capital, Beijing. @entity5784 levels were determined using a double reagent enzymatic cycling method. @entity3562 ( @entity5784 > 10  mol/L) was defined by the criteria of the American Heart Association. RESULTS: The Kazakh geometrical mean of @entity5784 was 13.34  mol/L, and the Uyghur mean was 13.75  mol/L; the mean values were higher in males than in females of both ethnicities (15.99  mol/L vs. 11.63  mol/L; 15.71  mol/L vs. 11.91  mol/L, respectively, p < 0.01). The serum levels of @entity5784 increased with increasing age in both ethnicities, and except for Kazakh individuals >65 years old, @entity5784 serum levels were higher in males than in females in all age groups of both ethnicities, with a p value less than 0.01. The Kazakh prevalence of @entity3562 was 80.0%, and the Uyghur prevalence was 78.2%; the male prevalence was higher than that in females for both ethnicities (93.5% vs. 69.6%; 90.8% vs. 64.6%, respectively, p < 0.05). Among the Kazakh, the prevalence of @entity101 was 35.1%, and the prevalence was higher in males than in females (44.3% vs. 28.1%, p < 0.001); 87.6% of the Kazakh individuals had @entity8108 -type @entity101 , and the prevalence was higher in males than in females (95.0% vs. 80.0%, p < 0.05). In Uyghur, the prevalence of @entity101 was 30.6%, and the prevalence was higher in males than in females (37.9% vs. 22.8%, p < 0.001); 88.0% of the Uyghur individuals had @entity8108 -type @entity101 , and the prevalence was higher in males than in females (93.9% vs. 79.1%, p < 0.05). CONCLUSIONS: @entity3562 was found to be common among the Kazakh and Uyghur. The prevalences of @entity3562 and @entity8108 -type @entity101 were high among both ethnicities and differed depending on gender and age. Community interventions should be conducted to improve @entity283 conditions among the Kazakh and Uyghur in Xinjiang.

title: Ethnic differences in the prevalence of high XXXX levels among low-income rural kazakh and uyghur adults in far Western china and its implications for preventive @entity283 .

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'systolic hypertension']

entities_list: @entity283 :: ('OMIM:603663', 'Disease') :: ['public health']

entities_list: @entity1255 :: ('MESH:D006710', 'Chemical') :: ['Homocysteine']

entities_list: @entity3562 :: ('MESH:D020138', 'Disease') :: ['HHcy', 'hyperhomocysteinemia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1255 :: (MESH:D006710,Chemical) :: ['homocysteine']


abstract: PURPOSE: Potential @entity12325 ( @entity12325 ) drug-drug interactions in adults with metastatic @entity5 and their effect on eligibility for Phase I clinical trials were characterized. METHODS: This study included adult @entity1 with metastatic @entity5 seen by a medical oncologist from January 2008 through July 2011. The medications used by these @entity1 were identified. Each medication's potential for interacting with @entity12325 isozymes was also characterized. Medication changes required to meet Phase I trial eligibility criteria were also reviewed. RESULTS: Data from 1773 @entity1 were analyzed: 1489 were not enrolled in a Phase I trial and 284 were enrolled in a Phase I trial. Polypharmacy was significantly more prevalent in the group enrolled in a Phase I trial compared with those not enrolled (95% versus 80%, p < 0.001). The majority of @entity1 not enrolled in a Phase I trial were taking at least one @entity12325 isozyme inhibitor (87%) and at least one @entity12325 isozyme inducer (45%). In a separate analysis, four Phase I trials were evaluated. Of 295 screened @entity1 , 3.2% could not enroll due to concurrent medications. Charts from 74 enrolled @entity1 revealed 655 concurrent medications-93 medications required further review for eligibility involving 51 (69%) of @entity1 . Of the 93 medications, 38 (41%) were stopped and 41 (44%) were changed for the study. CONCLUSION: Polypharmacy and the use of medications that interact with @entity12325 isoyzmes were common in adult @entity1 with metastatic @entity5 . @entity1 enrolling in Phase I studies often require medication changes to meet eligibility requirements.

title: Potential XXXX drug-drug interactions in adults with metastatic @entity5 and effect on eligibility for Phase I clinical trials.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['solid tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

answer: @entity12325 :: (4051,Gene) :: ['cytochrome P-450']


abstract: PURPOSE: Approximately 50% of @entity463 ( @entity463 ) are characterized by overexpression of the @entity470 ( @entity470 ) and @entity470 gene amplification. In approximately 25% of instances, constitutively activated @entity470 mutants are present. These observations make @entity470 -inhibiting drugs a logical approach for trials in recurrent GBM. @entity1 AND METHODS: In a randomized, controlled, phase II trial, 110 @entity1 with progressive GBM after prior radiotherapy were randomly assigned to either @entity3866 or a control arm that received treatment with either @entity2903 or @entity3600 (BCNU). The primary end point was 6-month progression-free survival (PFS). Tumor specimens obtained at first surgery were investigated for @entity470 expression; EGFRvIII mutants; @entity470 amplification; @entity470 mutations in exons 18, 19, and 21; and pAkt. These results were correlated with outcome. Pharmacokinetic analysis was part of the study. RESULTS; Treatment was well tolerated in general; @entity137 was the most frequent adverse effect of @entity3866 . The 6-month PFS rate in the @entity3866 arm was 11.4% (95% CI, 4.6% to 21.5%), and it was 24% in the control arm. Of all explored biomarkers, only low pAkt expression appeared to be of borderline significance to an improved outcome. None of the eight @entity1 who had @entity5 with EGFRvIII mutant presence and @entity983 expression had 6-month PFS. The use of enzyme-inducing anticonvulsants significantly increased @entity3866 clearance, but pharmacokinetic findings were not related to outcome. CONCLUSION: @entity3866 has insufficient single-agent activity in unselected GBM. No clear biomarker associated with improved outcome to @entity3866 was identified.

title: Randomized phase II trial of @entity3866 versus XXXX or @entity3600 in recurrent @entity463 : EORTC brain tumor group study 26034.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['skin toxicity']

entities_list: @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity3600 :: ('MESH:D002330', 'Chemical') :: ['carmustine']

entities_list: @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'GBMs']

entities_list: @entity3866 :: ('MESH:C400278', 'Chemical') :: ['erlotinib', 'Erlotinib']

answer: @entity2903 :: (MESH:C047246,Chemical) :: ['temozolomide']


abstract: UNASSIGNED: Endoplasmic reticulum @entity1520 oxidase @entity41053 plays a role in the formation of @entity1520 bonds in collaboration with protein @entity1520 isomerase. @entity1520 bond formation is required for the proper conformation and function of secreted and cell surface proteins. We found that @entity41053 was overexpressed in a variety of @entity5 types; therefore, we examined its role in @entity5 growth. In BALB/c @entity19 , knockdown of @entity41053 within 4T1 @entity19 mammary gland @entity5 ( @entity573 ) cells caused retardation of in vivo @entity5 growth compared with @entity5 growth of scrambled control (SCR) cells. In contrast, when @entity41053 -overexpressed 4T1 (OE) cells were compared with mock control cells, OE cells showed augmented @entity5 growth. However, differences in @entity5 growth were not observed among four groups of @entity19 , suggesting that expression of @entity41053 diminished antitumor immunity. We observed dense peritumoral granulocytic infiltrates in @entity5 of wild-type 4T1 and SCR cells but not @entity573 cells, and these cells were identified as polymorphonuclear myeloid-derived suppressor cells (MDSCs). In addition, production of @entity14541 and @entity60553 , which have intramolecular @entity1520 bonds, from @entity573 cells was significantly decreased compared with that from SCR cells. In contrast, OE cells produced a larger amount of these molecules than did mock cells. These changes were regulated at the posttranscriptional level. These results suggest that overexpression of @entity41053 in the @entity5 inhibits the T cell response by recruiting polymorphonuclear MDSCs via regulation of MDSC-prone cytokines and chemokines.

title: Cancer-Associated Oxidoreductase XXXX Drives the Production of Tumor-Promoting Myeloid-Derived Suppressor Cells via Oxidative Protein Folding.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'nude mice']

entities_list: @entity1520 :: ('CHEBI:48343', 'Chemical') :: ['Disulfide', 'disulfide']

answer: @entity41053 :: (50527(Tax:10090),Gene) :: ['ERO1-a']


abstract: @entity888 (MA) is one of the most frequently abused drugs worldwide. The aim of this study is to improve the analytical method for profiling MA impurity in order to compare and classify MA crystals seized in different countries and to investigate the relationships between @entity410 . To compare MA samples seized in Japan and Thailand, the following analytical method was adopted. A 50mg sample of MA. @entity5828 was dissolved in 1ml of buffer solution (four parts 0.1M phosphate buffer, pH 7.0, and one part 10% @entity4339 ), impurities were extracted with 0.5ml of @entity1046 containing four internal standards ( @entity37125 , @entity40042 , @entity61065 and @entity61066 ) and analyzed by gas chromatography with a flame ionization detector on a DB-5 capillary column (0.32mm i.d.x30m, film thickness 1.0mum). Fourteen characteristic peaks on chromatograms were selected for the comparison and classification of samples, and the data were evaluated by the Euclidean distance of the relative peak areas after logarithmic transformation. Sixty-nine samples seized in Japan and 42 seized in Thailand were analyzed. The samples were classified into four groups roughly by cluster analysis. In addition, when it was difficult to compare samples that had fewer impurities on chromatograms obtained from liquid-liquid extraction (LLE), solid-phase microextraction (SPME) was effective. Because many characteristic peaks were detected using SPME, SPME made it easy to compare samples of high purity. The combination of LLE and SPME was useful for impurity profiling of MA samples seized in different countries.

title: Comparison and classification of XXXX seized in Japan and Thailand using gas chromatography with liquid-liquid extraction and solid-phase microextraction.

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate']

entities_list: @entity888 :: ('MESH:D008694', 'Chemical') :: ['Methamphetamine']

entities_list: @entity40042 :: ('MESH:C033245', 'Chemical') :: ['n-pentadecane']

entities_list: @entity61065 :: ('CHEBI:43619', 'Chemical') :: ['n-eicosane']

entities_list: @entity61066 :: ('CHEBI:32943', 'Chemical') :: ['n-octacosane']

answer: @entity888 :: (MESH:D008694,Chemical) :: ['methamphetamine']


abstract: Bone @entity3 is the most common @entity3 in @entity0 @entity1 . Clinical observations propose strong association between @entity172 receptor (ER)-positive @entity5 and the development of bone @entity3 . We hypothesized of biologically diverse sets of hormone-dependent @entity5 predisposed to bone @entity3 and of possible role of ER-signaling pathways in the development and progression of bone @entity3 . We developed a novel in vitro @entity172 (E2)-responsive model system, in which @entity0 cells and bone cells express high levels of either @entity1782 or @entity1783 . Using co-culture approach and gene array technology we identified E2-responsive genes involved in the interaction between @entity5 cells and bone cells. We detected 13 genes that were altered solely by @entity1782 and 11 genes that were regulated solely by @entity1783 in @entity5 cells. Only 5 genes were modified by both @entity1782 and @entity1783 . Interestingly, the majority of genes in bone cells were altered through @entity1783 . Two genes, namely @entity13978 and @entity2355 , whose changes in expressions in @entity5 cells in response to E2 were highly significant, were selected for immunohistochemical analysis using tissue microarrays of 59 infiltrating @entity513 . Our results indicated that both @entity13978 and @entity2355 were expressed at high frequency in @entity5 . The correlation between @entity1782 - and @entity1783 -status of hormone-dependent @entity5 with combined expression of these two markers might suggest a more aggressive @entity5 phenotype associated with bone @entity3 . Further analysis of tissues with clinicopathological characteristics and known bone @entity3 will indicate potential prognostic values of these and other markers in the development of bone @entity3 in a subgroup of "bad" hormone-dependent @entity0 .

title: Identification of @entity172 -responsive genes involved in XXXX @entity3 to the bone.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'ER-positive tumors', 'tumors']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases', 'metastatic disease']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: The present multicenter, randomized crossover study compared the safety and efficacy of continuous infusion with those of short infusions of @entity5505 in @entity1 with @entity1577 . @entity1 with chronic @entity796 colonization received two successive courses of intravenous @entity2890 and @entity5505 (200 mg/kg of body weight/day) for pulmonary exacerbation administered as thrice-daily short infusions or as a continuous infusion. The primary endpoint was the variation in the forced expiratory volume in 1 s (FEV1) during the course of antibiotic treatment. Sixty-nine of the 70 @entity1 enrolled in the study received at least one course of antibiotic treatment. The improvement in FEV1 at the end of therapy was not statistically different between the two treatment procedures (+7.6% after continuous infusion and +5.5% after short infusions) but was better after continuous @entity5505 treatment in @entity1 harboring resistant isolates (P < 0.05). The interval between the course of antibiotic treatments was longer after the continuous infusion than after the short infusion of @entity5505 (P = 0.04). The mean serum @entity5505 concentration during the continuous infusion was 56.2 +/- 23.2 microg/ml; the mean peak and trough concentrations during the short infusions were 216.3 +/- 71.5 and 12.1 +/- 8.7 microg/ml, respectively. The susceptibility profiles of the @entity796 isolates remained unchanged and were similar for both regimens. Quality-of-life scores were similar whatever the treatment procedure, but 82% of the @entity1 preferred the continuous-infusion regimen. Adverse events were not significantly different between the two regimens. In conclusion, the continuous infusion of @entity5505 did not increase its @entity137 and appeared to be as efficient as short infusions in @entity1 with @entity1577 as a whole, but it gave better results in @entity1 harboring resistant isolates of @entity796 .

title: Continuous versus intermittent infusions of XXXX for treating exacerbation of @entity1577 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa']

entities_list: @entity2890 :: ('MESH:D014031', 'Chemical') :: ['tobramycin']

entities_list: @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']

answer: @entity5505 :: (MESH:D002442,Chemical) :: ['ceftazidime']


abstract: Several randomised controlled trials have shown that pelvic floor muscle exercise has resulted in a 60-70% improvement or cure rate from @entity3142 . The aim of the present study was to assess whether these methods could be put into general use in a physiotherapy clinic in primary health care. 36 @entity1 , all with a diagnoses of stress urinary @entity322 , mean age 49 (range 25-67 years), participated in the study. Before treatment they underwent vaginal examination to ensure there was proper pelvic floor muscle contraction. Pelvic floor muscle strength was assessed by vaginal pressure measurement. Urinary leakage was registered on a 13-item "leakage index", using a 5-point graded scale (1 = never leakage to 5 = always leakage). The @entity1 attended a six-month pelvic floor muscle exercise programme, training in groups led by a physiotherapist, and exercising at home with three series of 8-12 contractions a day. 12 @entity1 reported to be cured, and 12 reported a significant improvement (67% in all). Five @entity1 achieved some improvement, whereas in another five there was no change. None became worse. It is concluded that pelvic floor muscle exercises, under the guidance of trained physiotherapists, may be just as effective in clinical practice as in randomised controlled trials.

title: [The effect of pelvic floor exercise on stress urinary XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

entities_list: @entity3142 :: ('MESH:D014550', 'Disease') :: ['stress incontinence']

answer: @entity322 :: (MESH:D014549,Disease) :: ['incontinence']


abstract: BACKGROUND: Continuous @entity413 monitoring (CGM) has been shown to improve @entity413 control in adults with type 1 @entity6 . Effectiveness of CGM is directly linked with CGM adherence, which can be challenging to maintain in @entity1 and adolescents. We hypothesize that initiating CGM at the same time as starting insulin pump therapy in pump na  ve @entity1 and adolescents with type 1 @entity6 will result in greater CGM adherence and effectiveness compared to delaying CGM introduction by 6 months, and that this is related to greater readiness for making behaviour change at the time of pump initiation. METHODS/DESIGN: The CGM TIME Trial is a multicenter randomized controlled trial. Eligible @entity1 and adolescents (5-18 years) with established type 1 @entity6 were randomized to simultaneous initiation of pump (Medtronic Veo  ) and CGM (Enlite  ) or to standard pump therapy with delayed CGM introduction. Primary outcomes are CGM adherence and hemoglobin @entity3916 at 6 and 12 months post pump initiation. Secondary outcomes include glycemic variability, stage of readiness, and other @entity1 -reported outcomes with follow-up to 24 months. 144 (95%) of the 152 eligible @entity1 were enrolled and randomized. Allowing for 10% withdrawals, this will provide 93% power to detect a between group difference in CGM adherence and 86% power to detect a between group difference in hemoglobin @entity3916 . Baseline characteristics were similar between the treatment groups. Analysis of 12 month primary outcomes will begin in September 2014. DISCUSSION: The CGM TIME Trial is the first study to examine the relationship between timing of CGM initiation, readiness for behaviour change, and subsequent CGM adherence in pump na  ve @entity1 and adolescents. Its findings will advance our understanding of when and how to initiate CGM in @entity1 and adolescents with type 1 @entity6 . TRIAL REGISTRATION: ClinicalTrial.gov NCT01295788. Registered 14 February 2011.

title: The JDRF CCTN CGM TIME Trial: Timing of Initiation of continuous @entity413 Monitoring in Established pediatric type 1 XXXX : study protocol, recruitment and baseline characteristics.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVE: During pregnancy cytokines and inflammatory mediators stimulate the expression of prostaglandin, the levels of which determine the onset of labor. The aim of this work was to study interleukin @entity1356 , @entity650 and @entity687 levels in the vaginal discharge, serum and urine of pregnant @entity1 with @entity281 before and after specific treatment. One hundred and fifty-one @entity1 were studied during the second or third trimester of their pregnancy. METHODS: The selected @entity1 were: healthy or control group (n = 52), those with @entity6981 (n = 47), those with @entity365 (n = 37), those with asymptomatic @entity293 (n = 15) and post-treatment. The level of cytokines was assayed by ELISA test. The Mann-Whitney U-test was used for statistical analysis. RESULTS: The @entity1356 levels in vaginal discharge were: control 103.5 +/- 24.2 pg/ml, @entity6981 1030 +/- 59.5, @entity365 749.14 +/- 66.7l ( p < 0.0001), post-treatment 101.4 +/- 28.7. @entity650 values were similar in both control and infected groups, and there were no @entity1 with @entity5870 . In vaginal discharge @entity650 : control 14.2 +/- 3.9 pg/ml, @entity6981 13.2 +/- 3.8, @entity365 13 +/- 4.2. @entity687 levels were: control 1643 +/- 130.3 pg/ml, @entity6981 2612.7 +/- 257.7, @entity365 3437 +/- 460 (p < 0.0001), post-treatment 1693 +/- 126.6. In urine the results were: control 40.2 +/- 17 pg/ml, asymptomatic @entity293 1200.7 +/- 375 (p < 0.0001). In @entity1 with therapeutic success both @entity1356 and @entity687 returned to normal levels. CONCLUSIONS: @entity281 induce a significant increase in @entity1356 and @entity687 levels in vaginal secretions, and @entity687 in urine as well. Both cytokines could be useful as evolutive markers of @entity281 .

title: XXXX , @entity650 and @entity687 levels in @entity281 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'Genitourinary infections', 'genitourinary infection']

entities_list: @entity6981 :: ('MESH:D016585', 'Disease') :: ['bacterial vaginosis']

entities_list: @entity365 :: ('MESH:D014627', 'Disease') :: ['vaginitis']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary infection']

answer: @entity1356 :: (3553,Gene) :: ['IL-1beta']


abstract: UNASSIGNED: @entity302 is a common @entity16 that leads to @entity528 and provoke various forms of cellular reorganization in the brain. In this study, we investigate the anti-convulsant and neuroprotective effects of thymoquinone (TQ) and vitamin C against pentylenetetrazole (PTZ)-induced generalized @entity410 . @entity302 were induced in adult @entity35 using systemic intraperitoneal injections of PTZ (50  mg/kg) for 7  days. Animals pretreated with either TQ or vitamin C or in combination attenuated PTZ-induced @entity410 and mortality in @entity35 as well neurodegeneration in the cells. Compared to PTZ, TQ and vitamin C significantly prolonged the onset of @entity410 (p  >  0.05) as well decrease the high-grade @entity410 . Analysis of electroencephalogram (EEG) recordings revealed that TQ or vitamin C supplementation significantly reduced polyspike and @entity302 . @entity302 caused a decline in expression of gamma-aminobutyric acid B1 receptor (GABAB1R) (p  >  0.05), unchanged expression of @entity12175 ( @entity12175 ), decreased calcium/calmodulin-dependent protein kinase II (CaMKII) (p  >  0.05) and inhibit the phosphorylation of @entity14889 ( @entity14889 ) (p  >  0.05) in cortex and hippocampus, respectively, compared with control. Changes in expression of GABAB1R, CaMKII and @entity14889 by PTZ were reversed by TQ and vitamin C supplementation. Moreover, PTZ significantly increased @entity2310 , decreased @entity1976 expression and finally the activation of @entity4124 . TQ and vitamin C pretreatment reversed all these deleterious effects induced by PTZ. TQ and vitamin C showed anticonvulsant effects via activation of GABAB1R/CaMKII/ @entity14889 pathway and suggest a potential therapeutic role in @entity302 .

title: Thymoquinone and Vitamin C Attenuates Pentylenetetrazole-Induced XXXX Via Activation of GABAB1 Receptor in Adult @entity35 Cortex and Hippocampus.

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorder']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Epileptic seizures', 'epilepsy', 'Epilepsy', 'epileptiform discharges']

entities_list: @entity14889 :: ('81646(Tax:10116)', 'Gene') :: ['cAMP response element-binding protein', 'CREB']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal excitability']

answer: @entity410 :: (MESH:D012640,Disease) :: ['Seizures']


abstract: INTRODUCTION: Social determinants of health play an important role in explaining poor health outcomes across many @entity102 states. The impact of the social gradient in the setting of an inherited @entity299 , @entity1121 ( @entity1121 ), has not been investigated. This study sought to profile the socioeconomic status of @entity1 attending a specialized multidisciplinary clinic and to determine the impact on clinical factors, psychosocial wellbeing and adherence to medical advice. METHODS: @entity1 with @entity1121 and at-risk relatives attending a specialized multidisciplinary clinic in Sydney Australia between 2011 and 2013 were included. Clinical, socioeconomic, geographic remoteness and adherence data were available. A broader clinic and registry-based group completed a survey including psychological wellbeing, health-related quality of life, Morisky Medication Adherence Scale and individual-level socioeconomic information. RESULTS: Over a 3-year period, 486 @entity1 were seen in the specialized clinic. There was an over-representation of @entity1 from socioeconomically advantaged and the least geographically remote areas. Socioeconomic disadvantage was associated with comorbidities, poor psychological wellbeing and health-related quality of life, lower understanding of @entity1121 and more complex clinical management issues such as NYHA class, @entity955 and @entity3585 . Approximately 10% of @entity1 were non-adherent to medical advice, and poor medication adherence was seen in 30% of @entity1121 @entity1 with associated factors being younger age, minority ethnicity, @entity148 and poor mental quality of life. CONCLUSIONS: Of all the @entity1 attending a specialized cardiac genetic clinic, there is an overrepresentation of @entity1 from very advantaged and major metropolitan areas and suggests that those most in need of a multidisciplinary approach to care are not accessing it.

title: Social determinants of health in the setting of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3585 :: ('MESH:D014694', 'Disease') :: ['left ventricular outflow tract obstruction']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy']

answer: @entity1121 :: (MESH:D002312,Disease) :: ['hypertrophic cardiomyopathy']


abstract: OBJECTIVES: Transcatheter aortic valve replacement (AVR) is a promising approach to @entity886 . The implications of this new therapy are not entirely known. We describe the potential for the development of new @entity713 . BACKGROUND: @entity713 is a known complication of conventional surgical AVR. Block is presumed to occur as a consequence of surgical @entity130 to the cardiac conduction tissue during excision of the diseased aortic valve and d  bridement of the calcified annulus. Whether @entity713 might occur as a consequence of nonsurgical implantation of an aortic stent valve is unknown. METHODS: We reviewed our experience with @entity1 undergoing transcatheter AVR using both the percutaneous transarterial and the open-chest direct left ventricular apical ventriculotomy approaches. @entity1 were considered at high risk for conventional surgery because of comorbidities. Continuous @entity943 monitoring was performed for at least 48 h after the valve implantation procedure. @entity1 who developed apparently new, clinically significant @entity713 were identified. RESULTS: Transcatheter AVR was successfully performed in 123 @entity1 . Seventeen of these @entity1 (13.8%) had pre-existing permanent pacemakers. Two @entity1 (1.6%) required pacemaker implantation because of pre-existing intermittent @entity1168 . Seven @entity1 (5.7%) developed new and sustained complete @entity713 requiring pacemaker implantation. An additional 4 @entity1 (3.3%) developed new and sustained @entity714 but did not require pacemaker implantation. CONCLUSIONS: As with conventional AVR surgery, transcatheter AVR may result in impaired @entity713 . Physicians and @entity1 should be aware of the potential for @entity713 and pacemaker @entity734 .

title: XXXX after transcatheter balloon expandable aortic valve implantation.

entities_list: @entity714 :: ('MESH:D002037', 'Disease') :: ['left bundle branch block']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['AV block', 'atrioventricular conduction', 'atrioventricular (AV) block', 'Atrioventricular block']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve disease']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence']

answer: @entity713 :: (MESH:D054537,Disease) :: ['Atrioventricular block']


abstract: This study was conducted to evaluate the prevalence of transient @entity4089 in @entity249 @entity1 with @entity942 . One hundred fifty-one @entity942 @entity1 and 11 controls had serum prolactin (PRL) measured daily for 3-4 days near ovulation. Thirty-three subjects (21.9%) had transient @entity4089 , with PRL above 20 ng/mL for 1 or 2 days, and were studied further. The blood samples of these 33 subjects and of the controls were also analyzed for LH and FSH. Plasma @entity1420 was measured on the fourth, seventh, and tenth days after ovulation in both groups. The mean (+/- SD) of the mid-cycle integrated LH surge (125.0 +/- 23.0 mIU/mL; N = 26) and the sum of three plasma @entity1420 levels (23.8 +/- 4.5 ng/mL; N = 21) in the @entity942 @entity1 were significantly (P less than .001) lower than those of the controls (LH 158.7 +/- 13.8 mIU/mL; @entity1420 33.8 +/- 6.5 ng/mL). All 33 @entity942 subjects with transient @entity4089 were treated with @entity2847 at a dose ranging from 1.25-5 mg/day to maintain mid-cycle PRL levels between 5-15 ng/mL. Both the integrated LH surge and the sum of three @entity1420 levels increased significantly (P less than .05) during @entity2847 treatment, to 142.6 +/- 22.4 mIU/mL (N = 20) and 28.2 +/- 6.2 ng/mL (N = 18), respectively. Fourteen of the 33 @entity1 conceived. The cumulative probability of conception was 31% for six cycles and 45% for 12 cycles of treatment.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Transient @entity4089 in @entity249 XXXX with @entity942 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinemia']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertile']

entities_list: @entity2847 :: ('MESH:D001971', 'Chemical') :: ['bromocriptine']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['luteal phase deficiency']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: AIM: In course of @entity1575 , esophageal varices develop with an incidence of 8-15% a year, and they constitute a sign of seriousness of portal @entity101 . The risk of @entity548 is estimated around 10-15% a year. The @entity548 causes a high rate of mortality (around 30-35% for every hemorrhagic event). It follows that it is necessary to plan prophylactic strategies for all the cirrhotic @entity1 , who are at risk of @entity548 , or have already bled. Medical treatment with beta-blockers is indicated in the prophylaxis of the first @entity548 , while endoscopic treatment represents now the most effective methodology either in @entity548 , or in the prophylaxis of @entity548 relapses. The available endoscopic methodologies are the @entity1463 or band ligation of esophageal varices. However, unanimous consent about the greater effectiveness of a methodology compared to the other one doesn't exist. As far as the varices eradication is concerned, the authors have done a research to verify if the combined techniques, proposed in various studies appeared in literature, can have some advantages, in comparison with the single methodologies. METHODS: Thirty-seven @entity1 have been treated: 27 only with @entity1463 and 10 with combined methodology (band-ligation followed by @entity1463 of the small residual varices). RESULTS: The group treated with the combined therapy have shown a reduction in relapses and in the main side effects and a better @entity1 ' compliance. CONCLUSIONS: The combination of the two methodologies can have some advantages as for security, easiness of execution, reduction in complications, in varices relapse and, therefore, in the hemorrhagic relapses.

title: The combined endoscopic therapy (band ligation and XXXX ) in the eradication of the esophageal varices in the cirrhotic @entity1 : our experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'bleeding', 'varices hemorrhage', 'acute bleeding']

entities_list: @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

answer: @entity1463 :: (MESH:D012598,Disease) :: ['sclerosis']


abstract: Both cardiac myocytes and cardiac stem cells (CSCs) express the receptor of @entity11523 ( @entity11523 ), activation of which improves injury responses after @entity583 ( @entity583 ). Here we show that a @entity11523 -agonist ( @entity11523 -A; @entity46703 ) reverses @entity5707 and enhances functional recovery in the setting of chronic @entity583 . This response is mediated entirely by activation of @entity56965 ( @entity56965 ), as demonstrated by the use of a highly selective @entity11523 antagonist ( @entity16384 ). One month after @entity583 , animals were randomly assigned to receive: placebo, @entity11523 -A ( @entity46703 ), @entity35 recombinant GH, @entity16384 , or a combination of @entity11523 -A and @entity16384 , for a 4-wk period. We assessed cardiac performance and hemodynamics by using echocardiography and micromanometry derived pressure-volume loops. Morphometric measurements were carried out to determine @entity583 size and capillary density, and the expression of @entity56965 was assessed by immunofluorescence and quantitative RT-PCR. @entity11523 -A markedly improved cardiac function as shown by echocardiographic and hemodynamic parameters. @entity583 size was substantially reduced, whereas myocyte and nonmyocyte mitosis was markedly increased by @entity11523 -A. These effects occurred without increases in circulating levels of growth hormone and insulin-like growth factor I and were, at least partially, nullified by @entity11523 antagonism, confirming a receptor-mediated mechanism. @entity11523 -A stimulated CSCs proliferation ex vivo, in a manner offset by @entity16384 . Collectively, our findings reveal the importance of the @entity11523 signaling pathway within the heart. Therapy with @entity11523 -A although initiated 1 mo after @entity583 substantially improved cardiac performance and reduced @entity1188 size, suggesting a regenerative process. Therefore, activation of @entity56965 provides a unique therapeutic approach to reverse remodeling after @entity583 .

title: Activation of @entity56965 stimulates cardiac reverse remodeling after XXXX ( @entity583 ).

entities_list: @entity11523 :: ('29446(Tax:10116)', 'Gene') :: ['growth hormone releasing hormone', 'GHRH']

entities_list: @entity5707 :: ('MESH:D020257', 'Disease') :: ['ventricular remodeling']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: The @entity29302 / @entity29302 / @entity29302 / @entity29302 gene encodes an RNA-binding Puf-family protein in @entity375 . The Deltampt5 cells exhibit pleiotropic phenotypes, including the G2/M arrest of the cell cycle and weakened cell wall at high temperatures. The Deltampt5 disruptant was also @entity1862 (HU) sensitive. In this study we screened deletion suppressors to rescue the temperature sensitivity of Deltampt5, and identified @entity59165 (YEL070W), @entity59166 (YBR007C), sir2, @entity34707 , @entity13442 and swe1. Multicopy suppressors identified were @entity19623 and its upstream genes, but not the downstream MAPK cascade genes. The overexpression of @entity19623 , however, did not suppress the HU sensitivity of Deltampt5. In contrast, both the HU- and temperature-sensitivities of a-type Deltampt5 cells were suppressed by each sir deletion or a multicopy of @entity34215 , suggesting that a diploid-type expression is involved. We found that a diploid-specific @entity59167 gene encoding an RNA-modifying protein was responsible for the suppression of the temperature sensitivity, but not of the HU sensitivity. Furthermore, the suppression of the HU sensitivity depended on @entity59168 , another Puf-family gene, and overexpression of @entity59168 suppressed only the HU sensitivity of Deltampt5. The protein level of @entity59168 was not affected by the sir mutation. Thus, these @entity59167 and @entity59168 proteins play complementary roles to rescue the defects in Deltampt5 Deltasir cells.

title: Suppressor analysis of the XXXX / @entity29302 / @entity29302 / @entity29302 deletion in @entity375 .

entities_list: @entity1862 :: ('MESH:D006918', 'Chemical') :: ['hydroxyurea']

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

answer: @entity29302 :: (852697(Tax:4932),Gene) :: ['mpt5']


abstract: OBJECTIVE: Computer-assisted image analysis was attempted to ascertain, if any of the previously described histologic features along with argyrophilic nucleolar organizer regions (AgNORs) could be used to determine the @entity146 of the @entity89 (CGCG), @entity2253 (PGCG) and @entity2967 of the long bones ( @entity1777 ). STUDY DESIGN: The study consisted of 20 cases of CGCG, 20 cases of PGCG and 5 cases of @entity1777 . The histological features included were number of giant cells, number of nuclei in each giant cell, number of blood vessels, @entity11644 ( @entity11644 ) and @entity5562 ( @entity5562 ) of giant cells. The histologic parameters were measured using Motic image plus analyzer and AgNORs were evaluated using @entity575 stain. RESULTS: The statistical analysis showed significant differences among various histological parameters between CGCG, PGCG and @entity1777 . A statistically significant difference was noted for the mean number of nuclei, @entity11644 and @entity5562 when @entity1777 was compared with CGCG and PGCG. @entity11644 of histologically aggressive @entity2253 (HA-CGCG) was more compared to histologically non-aggressive @entity2253 (HNA-CGCG). No statistical correlation was observed for AgNORs of multinucleated giant cells and mononuclear cells among CGCG, PGCG and @entity1777 . CONCLUSION: Based on the present study findings, CGCG and @entity1777 are distinct and separate entities and not a continuum of a single disease process. Histological parameters alone have a little implication on predicting clinical behavior of CGCG. AgNORs alone as a proliferative marker has a limited value in assessing the proliferation potential of giant cell lesions.

title: Computer assisted histomorphologic comparision and the expression of AgNORs in the central and peripheral giant cell lesions of the oral cavity and XXXX of the long bone.

entities_list: @entity2253 :: ('MESH:D006101', 'Disease') :: ['central giant cell granuloma', 'peripheral giant cell granuloma of the oral cavity']

entities_list: @entity11644 :: ('MESH:C564120', 'Disease') :: ['FSA', 'fractional surface area']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity2967 :: ('MESH:D005870', 'Disease') :: ['giant cell tumor']

entities_list: @entity5562 :: ('MESH:D015875', 'Disease') :: ['RSI', 'relative size index']

entities_list: @entity89 :: ('MESH:D007571', 'Disease') :: ['central giant cell granuloma of the jaws']

answer: @entity2967 :: (MESH:D005870,Disease) :: ['giant cell tumor']


abstract: BACKGROUND: Optimal timing of operative treatment of @entity174 in polytraumatized @entity1 depends on the type and location of the @entity174 , as well as on the cardiorespiratory stability of the @entity1 , and should be early in diaphyseal @entity174 in order to optimize intensive care treatment. The timing of surgery in cases of @entity3140 is secondary to life-saving therapies. The same applies to stabilization of @entity174 of the lower limbs, including @entity174 of the femur and tibial shaft. METHODS: The recommended operative procedure for adult polytraumatized @entity1 with closed or open humeral shaft @entity174 of grade I or II is intramedullary nailing or plating. For closed or open lower arm @entity174 of grade I or II, plating is the best procedure, or alternatively nailing. For upper extremity epi- or metaphyseal @entity174 plating is preferred. Specific @entity174 situations require specific operative treatments, for example traction band for olecranon @entity174 , external fixation for distal radial multi-fragmentary @entity174 . The external fixator may be the optimal approach in grade III open @entity174 of the upper extremity long bones. The main difference in paediatric @entity174 is not the timing of the procedure, but the selection of the technique, which has to respect the epiphyseal growth plates. RESULTS: Additional @entity130 require quick diagnosis and early vessel reconstruction in the presence of cardiopulmonary stability. @entity4422 should have a higher therapeutic priority if they are associated with @entity66 . The strategy in additional nerve @entity130 depends on the type of lesion. Nerve decompression should take place together with @entity174 stabilization; necessary nerve reconstruction should be performed secondarily. The primary phase should be limited to @entity174 fixation. If the @entity174 is combined with a @entity2054 , decompression by fasciotomy together with @entity174 fixation ensuring cardiopulmonary stability has be performed. CONCLUSION: Amputations at the upper extremity in polytraumatized @entity1 are only occasionally indicated in very severe @entity130 . In @entity130 involving total amputation, depending on the condition of the limb, immediate reattachment should be attempted if the cardiorespiratory situation of the @entity1 is stable.

title: [Operative strategies in the treatment of XXXX in polytraumatized @entity1 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['vessel/nerve lesions']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'upper extremity long bone fractures', 'fracture']

entities_list: @entity4422 :: ('MESH:D005597', 'Disease') :: ['Open fractures']

entities_list: @entity3140 :: ('MESH:D038062', 'Disease') :: ['upper limb fractures']

entities_list: @entity2054 :: ('MESH:D003161', 'Disease') :: ['compartment syndrome']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'vessel injuries']

answer: @entity3140 :: (MESH:D038062,Disease) :: ['upper limb fractures']


abstract: Recent epidemiological studies have demonstrated that consumption of certain natural products can lower @entity5 risk in @entity1 . For example, plant-derived @entity16296 have been shown to exert chemopreventive effects against @entity5 in vitro and in vivo. In the present study, the effects of three such @entity16296 , termed @entity61326 , @entity24738 , and @entity2604 ( @entity2605 ), on the proliferation of @entity1534 and the prevention of @entity1534 -associated @entity356 were investigated in Mongolian gerbils. To examine the effects of @entity24738 and @entity2605 on stomach carcinogenesis, specific pathogen-free male, 5-week-old gerbils were infected with @entity1534 , administered 10 p.p.m. @entity7044 in their drinking water and fed diets containing various concentrations of @entity16296 until they were killed after 52 weeks. At a dietary level of 0.25%, @entity2605 significantly decreased the incidence of @entity356 . @entity24738 , in contrast, @entity536 at a level of 0.1%. Both @entity2605 and @entity24738 significantly reduced serum @entity7599 levels at doses of 0.25 and 0.05% ( @entity2605 ), and 0.1% ( @entity24738 ). Administration of 0.25% @entity2605 significantly suppressed the formation of intestinal metaplasia both in the antrum and the corpus. Although all three @entity16296 dose-dependently inhibited the in vitro proliferation of @entity1534 , there were no differences in the titers of anti-H. @entity1534 antibodies or the amount of the @entity1534 -specific urease A gene among all @entity1534 -infected groups. These results suggest that @entity2605 might be effective for prevention of @entity356 . The possible mechanisms appear to be related to inhibitory effects on progression of @entity3621 and antioxidative activity rather than direct antimicrobial influence.

title: Inhibitory effect of @entity2604 , a plant lignan, on XXXX -associated @entity356 in Mongolian gerbils.

entities_list: @entity24738 :: ('MESH:C071942', 'Chemical') :: ['Arctigenin', 'arctigenin']

entities_list: @entity7599 :: ('MESH:C040791', 'Chemical') :: ["8-hydroxy-2'-deoxyguanosine"]

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2604 :: ('MESH:D009637', 'Chemical') :: ['nordihydroguaiaretic acid']

entities_list: @entity536 :: ('MESH:C538265', 'Disease') :: ['failed to attenuate neoplasia']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'gastric adenocarcinomas', 'gastric carcinogenesis']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity1534 :: ('210', 'Species') :: ['H. pylori', 'pylori', 'Helicobacter pylori']

entities_list: @entity7044 :: ('MESH:D008770', 'Chemical') :: ['N-methyl-N-nitrosourea']

answer: @entity1534 :: (210,Species) :: ['Helicobacter pylori']


abstract: Adverse left ventricular (LV) remodeling after acute @entity583 is characterized by @entity5988 and development of a @entity2318 , and is a critical factor for the prognosis of subsequent development of @entity712 . Although myofiber organization is recognized as being important for preserving physiological cardiac function and structure, the anatomical features of injured myofibers during LV remodeling have not been fully defined. In a @entity19 model of @entity63 -reperfusion (I/R) injury induced by left anterior descending coronary artery ligation, our previous histological assays demonstrated that broad fibrotic scarring extended from the initial infarct zone to the remote zone, and was clearly demarcated along midcircumferential myofibers. Additionally, no @entity82 was observed in longitudinal myofibers in the subendocardium and subepicardium. However, a histological analysis of tissue sections does not adequately indicate @entity130 distribution throughout the entire heart. To address this, we investigated patterns of scar formation along myofibers using three-dimensional (3D) images obtained from multiple tissue sections from @entity19 hearts subjected to I/R injury. The @entity2318 area observed in the 3D images was consistent with the distribution of the midcircumferential myofibers. At the apex, the scar formation tracked along the myofibers in an incomplete C-shaped ring that converged to a triangular shape toward the end. Our findings suggest that @entity130 after transient coronary ligation extends along myofibers, rather than following the path of coronary arteries penetrating the myocardium. The injury pattern observed along myofibers after I/R injury could be used to predict prognoses for @entity1 with @entity583 .

title: Three-dimensional myocardial scarring along myofibers after XXXX -reperfusion revealed by computerized images of histological assays.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity5988 :: ('MESH:C565277', 'Disease') :: ['LV dilatation']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity2318 :: ('MESH:D002921', 'Disease') :: ['fibrotic scar']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['myocyte injury', 'myofiber injury']

answer: @entity63 :: (MESH:D007511,Disease) :: ['coronary ischemia']


abstract: STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the prognostic value of preoperative pulmonary function test (PFT) for @entity260 and to identify the operability associated with severely decreased forced vital capacity (FVC) (<30%) status in flaccid @entity4094 . SUMMARY OF BACKGROUND DATA: The preoperative PFT, especially more than 30% FVC, is known as a critical factor for the operability of flaccid @entity4094 . But only one study reported that @entity1 with pre-existing @entity1576 on nocturnal noninvasive ventilation can undergo an operation for deformity correction without mortality and severe complications. METHODS: A total of 74 @entity1 (45 male and 29 female) presented with flaccid @entity4094 . For all @entity1 , preoperative PFTs were evaluated and subdivided into three groups (<30% FVC, 30%-50% FVC, and >50% FVC). Then @entity260 , pneumothorax, @entity55 , @entity891 , prolonged ventilator care in the intensive care unit (more than 72 hours), and postoperative tracheostomy were evaluated. RESULTS: Among these @entity1 , 59 had @entity3986 ; 5, @entity2057 ; 2, @entity306 ; and 8, others. The mean age at surgery was 16.8 years (range, 5-32 years). The mean preoperative Cobb angle was 54.6   (16  -135  ). The overall postoperative pulmonary complication rate was 31% (23 complications in 74 @entity1 ). The less than 30% FVC group had 6 complications among 18 @entity1 ; the 30% to 50% FVC group had 7 complications among 18 @entity1 ; and the more than 50% FVC group had 10 complications among 38 @entity1 . There were no deaths during the perioperative period. There is no statistical difference between the three groups (P = 0.6195). CONCLUSION: @entity1 with flaccid @entity4094 can undergo an operation for deformity correction regardless of the severely @entity6314 .

title: Value of preoperative pulmonary function test in flaccid XXXX surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular scoliosis']

entities_list: @entity6314 :: ('MESH:D006315', 'Disease') :: ['decreased pulmonary function']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['muscular dystrophy']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative pulmonary complications']

entities_list: @entity891 :: ('MESH:D001261', 'Disease') :: ['atelectasis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity2057 :: ('MESH:D009133', 'Disease') :: ['spinal muscular atrophy']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity4094 :: (MESH:D009468,Disease) :: ['neuromuscular scoliosis']


abstract: The finding of a raised @entity1881 concentration in the heart muscle, liver, skeletal muscle and serum during experimental @entity1378 , lasting 30 days, made the authors assume that this cumulation is a transient phenomenon which would disappear during a prolonged @entity209 as a result of energetic breakdown of the organism. The purpose of the paper was to verify this view. The investigation with experimental hyper- and @entity1375 was made in 120 @entity35 with a mean weight of 160 g. To 60 animals daily 100 mug thyroxin were administered by the i.p. route, 48 animals were given 2.5 @entity38611 daily by mouth to induce @entity1375 and 12 animals served as controls. The animals were fed the same diet. The effect of the administered preparations was examined after 20, 30, 40, 50 and 60 days. In @entity1375 animals the 50th day was omitted. The results revealed: 1. In @entity1378 animals the body weight was almost constant to the end of the experiment. However these animals had a significantly raised weight of the heart muscle and liver, as compared with the remaining two groups. 2. In @entity1378 animals the highest @entity1881 concentration in the heart muscle and skeletal muscle was recorded after 20 days. During subsequent time intervals the @entity1881 concentration in the heart muscle declined gradually. In the skeletal muscle a dramatic decline occurred after 40 days and proceeded to the end of the investigation when the recorded values were at the borderline of detectability. This finding confirmed the authors view that the @entity1881 cumulation in muscle exposed to an increased work load is a transient phenomenon and disappears during prolonged @entity1378 before the breakdown of the organism. 3. In @entity1378 no correlation was found between the @entity1881 concentration and the lipid content of organs and skeletal muscle. This correlation was found in @entity1375 . 4. The @entity1881 serum level in @entity1378 was significantly higher than in @entity1375 . 5. In @entity1378 the @entity1881 cumulation in liver increased gradually, and reached its maximum after 50 days. At a time when the @entity1881 concentration in the heart muscle and skeletal muscle declined already, its liver concentration increased. This phenomenon may be associated with the increasing protein synthesis in the liver during @entity1378 , or with other phenomena which call for further investigation.

title: Effect of hyper- and @entity1375 on the @entity1881 concentration in serum and some organs of growing XXXX .

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroid', 'hypothyroidism']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism', 'hyperthyroid']

entities_list: @entity1881 :: ('MESH:D024502', 'Chemical') :: ['alpha-tocopherol']

entities_list: @entity38611 :: ('CHEBI:617099', 'Chemical') :: ['Carbimazol']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorder']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: The origin of 20% of @entity385 is a @entity1002 . We report two @entity1 with @entity64 originating from cardiac thrombi, treated in two different ways. A 42-year-old @entity6 @entity1 admitted with a left parietal and @entity64 . An echocardiogram showed a @entity1002 . The @entity1 was subjected to a surgical cardiac revascularization procedure and left ventricular thrombectomy. The postoperative evolution was uneventful and the @entity1 was discharged on oral anticoagulation. On ambulatory follow up, no @entity16 was evidenced. A 38-year-old male admitted with an acute @entity385 , was subjected to thrombolysis with @entity1 plasminogen activator. An echocardiogram showed a @entity1002 , considered the cause of the @entity64 . The patient was anticoagulated with heparin and discharged ten days after admission with oral anticoagulation. A new echocardiogram performed one month later, did not show the @entity1002 .

title: [Management of XXXX derived from intraventricular thrombi: Report of two cases].

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient', 'man']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'occipital stroke', 'stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological deterioration']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular thrombus']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'ischemic strokes']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic strokes']


abstract: BACKGROUND: Few studies have investigated or identified common clinical tests and measures as being associated with progression of @entity570 ( @entity571 ); fewer still are longitudinal studies exploring prognostic variables associated with long-term outcome following physical therapy treatment. OBJECTIVE: The purpose of this study was to determine a set of prognostic factors that maximize the accuracy of identifying @entity1 with @entity570 ( @entity571 ) likely to demonstrate a favorable response to physical therapy intervention. DESIGN: This was a prognostic study. METHODS: Ninety-one @entity1 with a clinical diagnosis of @entity570 were analyzed to determine which clinical measures, when clustered together, were most predictive of a favorable response to physical therapy intervention. Responders were determined based on OMERACT-OARSI response criteria, which included percent and absolute changes in @entity158 , function, and global rating of change over 1 year. These data served as the reference standard for determining the predictive validity of baseline clinical examination variables. Using multivariate regression analyses and calculations for sensitivity, specificity, and positive and negative likelihood ratios, a cluster was identified. RESULTS: Five baseline variables (unilateral hip @entity158 , age of  <=58 years, @entity158 of >= 6/10 on a numeric @entity158 rating scale, 40-m self-paced walk test time of  <=25.9 seconds, and duration of symptoms of  <=1 year) were retained in the final model. Failure to exhibit a condition of 1 of the 5 predictor variables decreased the posttest probability of responding favorably to physical therapy intervention from 32% to <1% (negative likelihood ratio=0.00, 95% confidence interval=0.00-0.70). Having at least 2 out of 5 predictor variables at baseline increased the posttest probability of success with physical therapy intervention from 32% to 65% (positive likelihood ratio=3.99, 95% confidence interval=2.66-4.48), and having 3 or more of 5 predictor variables increased the posttest probability of success to 99% or higher. A comparison with a control group that did not receive physical therapy further substantiated the cluster. LIMITATIONS: The small sample size and the number of variables entered into the logistic regression model may have resulted in spurious findings. This study must be validated in replication studies before it can be considered for use in clinical practice. CONCLUSIONS: This study completed the first step in the development of a preliminary cluster of baseline variables that identify @entity1 with @entity570 as positive responders to physical therapy intervention.

title: Predictors of response to physical therapy intervention in XXXX with primary @entity570 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity570 :: ('MESH:D015207', 'Disease') :: ['hip osteoarthritis', 'hip OA']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity1 experience severe @entity158 after craniotomy surgery that leads to discomfort. Our target in this study that performed in interventional method is an evaluation of @entity681 and @entity1443 effect on @entity282 control in @entity1 undergone craniotomy surgery at Urmia Imam Khomeini Hospital. MATERIALS AND METHODS: Totally, 45 @entity1 between the ages 18 and 65 were studied. The effect of @entity681 and @entity1443 medicines in @entity158 management, hemodynamic stability, and side effects compared with control group that were receiving @entity1286 (subcutaneous [SC]) in 3 groups of 15 @entity1 at time 0, 2, 4, 12 and 24-h were evaluated. Collected data were included and monitoring blood pressure, O2 Sat, heart rate (HR) and @entity158 , @entity390 , @entity391 and use of @entity1286 . RESULTS: According to the analysis of results, there was a significant difference between 3 groups on @entity282 (P < 0.05). In @entity1 that used @entity681 , @entity158 score of visual analog scale (VAS) is lowest and in the @entity1443 group the highest VAS score was seen. There was a significant difference in HR between 3 groups (P < 0.05). Maximum average of HR was observed in the @entity1443 group. There was a significant difference in mean arterial pressure between 3 groups (P < 0.05). In @entity1443 group, there was the highest value (99.3). There was no significant difference in Glasgow @entity772 scale and SPO2 between 3 groups (P > 0.05). CONCLUSION: @entity681 compared to @entity1286 (which is routinely used for @entity1 @entity158 control after craniotomy surgery) has @entity158 control, less @entity390 and @entity391 , and better hemodynamic stability. Although @entity1443 has the least @entity390 and @entity391 , it has the lowest quality of @entity158 relief.

title: Comparison the effects of @entity1443 with @entity681 infusion on XXXX control after craniotomy in @entity1 with brain tumor.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'people']

entities_list: @entity681 :: ('MESH:D017409', 'Chemical') :: ['Sufentanil', 'sufentanil']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['better pain', 'pain']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']


abstract: BACKGROUND: Antibodies to infliximab [ATI] and trough levels to infliximab [ @entity59924 ] are associated with loss of response in @entity29 [ @entity29 ]. The best way to predict loss of response [LOR] to infliximab [IFX] is unknown. METHODS: We conducted a prospective observational cohort study enrolling all @entity29 @entity1 who were in clinical remission at Week 14 after IFX treatment initiation. @entity59924 , ATI and @entity1851 [ @entity1851 ] level were measured at Week 22 [T1] and thereafter at every other IFX infusion. Loss of clinical response was defined by a flare requiring therapeutic change [IFX dose intensification, initiation of another drug class, and/or surgery]. RESULTS: A total of 93 @entity1 [59 @entity30 , mean duration of follow-up 17.2 months] were included; 32 @entity1 [34.4%] lost clinical response during follow-up. Cumulative probability of LOR was 50% at 20 months. Mean @entity59924 at T1 was significantly lower in @entity29 @entity1 with stable ATI as compared with those with transient ATI or without ATI [0.052, 3.34 ,and 4.29   g/ml, respectively; p = 0.001 between no ATI vs stable ATI, and p = 0.005 between stable and transient ATI] [p = 0.0001]. Three independent factors were predictive of LOR after Cox proportional hazards modelling: @entity59924 > 5.5   g/ml (hazard ratio [HR]: 0.21; 95% confidence interval [CI]: 0.05-0.89;p = 0.034) at T1, @entity1851 > 5mg/l [HR: 2.5; 95% CI: 1.16-5.26; p = 0.019] at T1, and stable ATI defined by two consecutive ATI > 20ng/ml [HR: 3.77; 95% CI: 1.45-10.0; p = 0.007]. Transient ATI did not influence LOR. CONCLUSIONS: LOR can be predicted based on a combination of @entity1851 , @entity59924 and stable ATI with a high degree of accuracy.

title: Combination of XXXX , Infliximab Trough Levels, and Stable but Not Transient Antibodies to Infliximab Are Associated With Loss of Response to Infliximab in @entity29 .

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel diseases', 'IBD']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1851 :: (1401,Gene) :: ['C-reactive Protein']


abstract: A series of 1,000 @entity1 has been studied. I. HEMATOMAE: They are nearly continuous during internal saphena stripping but depend on various parameters. 1) Anatomical: a) Varicose veins topography. Perforating veins. Perforating veins of the thigh cause @entity548 but reactions of venous construction are quite important and precocious not to observe subcutaneous bleedings. More or less "soft" stripping creates a reaction of reflex vasoconstriction. Fore saphenous vein of the thigh Hematomae are more and more numerous and important because the fore saphenous vein is a vein whose wall is thinner, more fragile and almost more superficial. b) Type of @entity1 . In an @entity28 @entity1 , @entity1410 seems to be more spectacular. In the thin @entity1 , it appears faster, if hematic expression is too late. 2) Stripping techniques: It is possible to propose different techniques of stripping, but none of them can lower specifically post-surgical hematomae. 3) Anaesthesiae: a) General anaesthesia. A bilateral surgery under general anaesthesia was helpful to observe in some cases a less important @entity1410 at the level of the second operated leg. b) Rachi-anaesthesia. Physiological vasoconstriction requires a latent period for this kind of anaethesia which causes a @entity912 due to a blockade of the sympathetic nerve. c) Local anaesthesia. It is obtained by crural block in association with injection of Xylocaine Adrenalina at the level of perforating veins of the thigh. This technique causes less hematomae. II. ABSCESSES: Only 4 cases out of 1,000 operated legs have been reported. No related pathology have been observed particularly about @entity3329 ( @entity13171 or lymphoedema), no previous infection known which could not have explained such complications. Therapy was simple: incision at mid-thigh and draining by lamina. The @entity1 recovered within two weeks.

title: [Complications of superficial venous surgery of the legs: thigh XXXX and abscess].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3329 :: ('MESH:D008206', 'Disease') :: ['lymphatic disorders']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['vasomotor paralysis']

entities_list: @entity13171 :: ('MESH:D004886', 'Disease') :: ['erysipelas']

answer: @entity1410 :: (MESH:D006406,Disease) :: ['hematomas']


abstract: Stimulation of @entity19 resident peritoneal cells (RPCs) by encapsulated strain 52 and acapsular strain 602 of @entity1327 was compared. Fresh serum was required for fungistasis of both strains. Encapsulated organisms were killed only if the RPCs were activated with @entity60 ) or if the organisms were opsonized with anticapsular immunoglobulin G (IgG). In contrast, acapsular organisms were killed by unactivated RPCs, with enhanced killing seen if the cells were activated with @entity60 . Except for unopsonized strain 52, all organisms of both strains were phagocytosed. The respiratory burst was stimulated in unactivated and @entity60 -activated RPCs by encapsulated strain 52 only if organisms were opsonized with both IgG and serum. In contrast, the burst was stimulated by acapsular strain 602, with or without opsonization. Only unopsonized strain 602 stimulated significant lysosomal enzyme release. @entity3542 synthesis by unactivated RPCs was seen only if strain 52 was opsonized with anticapsular IgG or if strain 602 was opsonized with serum. If RPCs were activated with @entity60 , then serum-opsonized strain 52 was also able to stimulate @entity3542 synthesis. Thus, RPC killing, phagocytosis, respiratory burst, lysosomal enzyme release, and @entity3542 synthesis following challenge by both unopsonized and opsonized with serum or anticapsular IgG strains 52 and 602 varied according to the surface properties of the organisms, the state of activation of the RPCs, and the particular RPC event studied. However, stimulation of @entity3542 synthesis was the only RPC event which correlated with killing of both strains.

title: Differential stimulation of @entity19 resident peritoneal cells by selectively opsonized encapsulated and acapsular XXXX .

entities_list: @entity1327 :: ('5207', 'Species') :: ['Cryptococcus neoformans']

entities_list: @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['IFN-gamma', 'gamma interferon (IFN-gamma']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['Nitrite', 'nitrite']

answer: @entity1327 :: (5207,Species) :: ['Cryptococcus neoformans']


abstract: Subjects with @entity1566 ( @entity1566 ) have been shown to have an adverse lipid profile. Prior studies performed with smaller numbers of subjects have not been able to demonstrate any relationship between the level and degree of the @entity51 and plasma lipid levels. Over a 2 year period we investigated the lipid profiles in 541 subjects from Rancho Los Amigos Medical Center, Downey, @entity7452 . Subjects were grouped by @entity1688 ( @entity1688 ; n = 247) or @entity451 ( @entity451 ; n = 294) and by subgroup for degree of @entity51 : complete @entity1688 (n = 156), incomplete @entity1688 (n = 91), complete @entity451 (n = 206) and incomplete @entity451 (n = 88). The serum high-density lipoprotein (HDL) @entity165 level was lower in the @entity1688 than in the @entity451 group (38 +/- 0.7 vs 45 +/- 0.8, P < 0.01). The group with @entity1688 had a higher percentage of subjects with serum HDL @entity165 values < 35 mg/dL [an independent risk factor for @entity301 ( @entity301 )] than those with @entity451 (38% vs 21%, P < 0.0001). A significant inverse relationship was found for degree of @entity51 and mean serum HDL @entity165 level (r = 0.19, P < 0.001), with the greater the deficit, the lower the serum HDL @entity165 level. Serum total @entity165 levels were higher in the @entity451 group than in the @entity1688 group (198 +/- 2.6 vs 184 +/- 2.6, P < 0.01). However, the ratio of total @entity165 to HDL @entity165 (a discriminator of risk for @entity301 ) was significantly lower in the @entity451 group than the @entity1688 group (4.8 vs 5.2%, P < 0.01). Thus, in @entity1 with @entity1566 a spectrum of depressed serum HDL @entity165 levels and increased cardiovascular risk occur, with the most adverse lipid changes correlating with the severity of @entity51 .

title: The effect of residual XXXX on serum lipoproteins in individuals with chronic @entity1566 .

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['Tetra', 'tetraplegia']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity7452 :: ('MESH:D004670', 'Disease') :: ['California']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['Para', 'paraplegia']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity51 :: (MESH:D009461,Disease) :: ['neurological deficit']


abstract: STUDY DESIGN: A double-blind study comparing the effects of @entity7062 and a placebo (normal saline) on @entity190 during spinal instrumentation for @entity4094 . OBJECTIVE: To determine the effectiveness of @entity7062 ( @entity7062 ) in reducing operative @entity190 in hemostatically normal @entity1 undergoing spinal fusion surgery for @entity4094 . SUMMARY OF BACKGROUND DATA: @entity7062 has been shown to improve bleeding times and to provide surgical hemostasis in @entity1 with @entity1423 . Its effect in reducing bleeding times in normal @entity1 has been the subject of debate in several surgical specialties. Recent observations that @entity7062 seems to reduce bleeding times and @entity190 in @entity1 undergoing spinal surgery for @entity4094 warranted a more focused analysis on its role in this surgical procedure. METHODS: @entity1 undergoing surgery for @entity4094 were randomly assigned to receive @entity7062 or placebo. Bleeding times and plasma clotting factors were measured before the administration of the @entity7062 or placebo and 60 minutes after. Operative @entity190 was carefully measured. RESULTS: Although the administration of @entity7062 decreased overall @entity190 by an average of 19% compared with @entity190 in the placebo group and @entity190 per vertebra fused by an average of 15%, these results were not statistically significant. CONCLUSIONS: Bleeding time and @entity190 seem to respond better to @entity7062 in some @entity1 , in whom significant decreases were observed, than they do in others. The problem is in identifying those @entity1 in whom a decrease in bleeding time will be elicited after administration of @entity7062 . Preoperative administration of @entity7062 to such @entity1 should significantly decrease operative @entity190 .

title: The influence of desmopressin on @entity190 during spinal fusion surgery in neuromuscular XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular scoliosis']

entities_list: @entity7062 :: ('MESH:D003894', 'Chemical') :: ['DDAVP', 'Desmopressin acetate', 'desmopressin acetate', 'desmopressin']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet disorders']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: To evaluate the efficacy and @entity137 of @entity900 , tegafur, and @entity4181 as neoadjuvant chemotherapy (CT) for @entity1 with advanced, nonmetastatic @entity213 ( @entity213 ). METHODS: @entity1 with @entity213 according to World Health Organization (WHO) performance status of 2 or less and adequate organ function were enrolled. The CT regimen (PTL) was 50 mg/m(2) @entity900 (P) on Day 1, 800 mg per day oral tegafur (T), and 60 mg per day oral @entity4181 (L) for 14 days. The CT was administered at outpatient clinics for 14-day cycles. PTL was initiated with the intent of organ preservation and it was continued for a maximum of six cycles before locoregional therapy. Reevaluation after three cycles led to the termination of CT when the response was less than a partial response. CT was discontinued immediately upon evidence of @entity5 progression or excessive @entity137 . RESULTS: From March 1996 through July 1999, 97 @entity1 were enrolled consecutively. All @entity1 were @entity1 with a median age of 56 years (range, 37-70 years). The primary @entity5 sites were the tongue base, 14, and the hypopharynx, 83. Sixteen percent of the @entity5 were Stage III, 84% were Stage IV, 62% were Stage T4, and 44% were Stage N2-3. The median number of CT cycles was six. On an intent-to-treat basis, 26 @entity1 (27%) achieved complete responses and 32 @entity1 (33%) achieved partial responses. The overall response rate was 60% (95% confidence interval, 50-70%). The most common @entity137 of WHO Grade 3 or higher included (percent of @entity1 ): @entity417 , 8.3%; @entity3136 , 6.3%; @entity882 , 3.1%; and @entity391 , 3.1%. With a median follow-up period of 3 years, the overall survival and disease-free survival rates were 40% and 38%, respectively. Organ preservation was achieved in 70% (29 of 37) of the surviving @entity1 . CONCLUSION: The outpatient PTL regimen was a moderately effective and minimally toxic CT for @entity213 . PTL should be studied further in combination with other active agents or radiotherapy for @entity1 with @entity213 .

title: @entity900 , tegafur, and @entity4181 : a moderately effective and minimally toxic outpatient neoadjuvant chemotherapy for locally advanced XXXX .

entities_list: @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'men']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['squamous cell carcinoma of the head and neck', 'SCCHN']

answer: @entity213 :: (MESH:C535575,Disease) :: ['squamous cell carcinoma of the head and neck']


abstract: Contrast produced by differences in regional proton relaxation times (T1 and T2) provides the potential to assess the extent of @entity583 using nuclear magnetic resonance (NMR) imaging. Previous laboratory studies have shown that longitudinal (T1) and transverse (T2) relaxation times are prolonged in acute @entity583 , and these prolongations have been attributed entirely to increases in tissue water content. The present study seeks to evaluate the relation between both T1 and T2 and regional myocardial perfusion and water content throughout a wide range of blood flow reduction. The left anterior descending coronary artery and collateral vessels supplying a region of the anterior wall of the left ventricle were ligated in 10 @entity235 for 4 hours until they were killed. Both water proton and bulk proton relaxation times of myocardial samples from @entity63 and control zones were measured at 200 and 20 MHz, respectively. Regions of severe @entity63 (flow less than 5% of control) demonstrated no significant alteration in T1 compared with nonischemic myocardium. Greatest T1 and T2 elevations were observed in moderately @entity63 myocardium (flow = 5 to 50% of control). The water relaxation behavior differed with the severity of the flow reduction and was not totally dependent on changes in water content. These data suggest that relaxation time alterations are more complex than previously reported in @entity741 insult. In the future, using T1 weighted imaging methods, @entity741 insults associated with severe reductions in blood flow would be anticipated to demonstrate a doughnut pattern with an area of abnormal intensity in the peripheral zone surrounding a central @entity63 zone with normal intensity.

title: Proton nuclear magnetic resonance relaxation times in severe XXXX .

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemic']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

answer: @entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']


abstract: STUDY DESIGN: Prospective, single-cohort study. OBJECTIVE: To evaluate @entity1514 using the Kaneda anterior spine dual-rod system (KASS). SUMMARY OF BACKGROUND DATA: In selected cases, anterior correction of @entity1635 has several advantages over the traditional posterior instrumentation. Other than 2 primary reports by Kaneda, there are no clinical outcome reports with the KASS in the literature. METHODS: A total of 24 @entity1 with @entity1514 (n = 10)/thoracolumbar (n = 14) @entity1635 were corrected using the KASS. Sagittal and coronal plane radiologic parameters were evaluated before surgery, 1-year after surgery, and at final follow-up (approximately 40 months). RESULTS: Average coronal correction of the primary curve was from 61 degrees to 24 degrees (61%). Apical @entity717 decreased by 69%. Apical vertebral translation decreased 10-2 cm. The secondary @entity1514 and lumbar curves showed a spontaneous correction between 27% and 46%, respectively. @entity1513 increased 25 degrees -38 degrees (52%), @entity1515 showed a minimal decrease from 48 degrees to 43 degrees . Fusion was achieved in all cases. No neurovascular or implant-related problems were observed at final follow-up. CONCLUSIONS: Anterior instrumented fusion for @entity1514 /thoracolumbar @entity1635 using the KASS is a good treatment option for @entity1514 .

title: Operative treatment of XXXX with the Kaneda anterior spine system.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1513 :: ('MESH:D007738', 'Disease') :: ['Thoracic kyphosis']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic', 'idiopathic thoracic/thoracolumbar curves', 'thoracic and thoracolumbar scoliosis']

entities_list: @entity1515 :: ('MESH:D008141', 'Disease') :: ['lumbar lordosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['vertebral rotation']

answer: @entity1635 :: (MESH:D012600,Disease) :: ['scoliosis']


abstract: BACKGROUND: @entity5 ( @entity5 ) is a distinctive @entity703 predominantly seen in females mostly in the perimenopausal period. Although these @entity5 are known to arise from renal pelvis, our case was distinct in that it had no intrapelvic component growing in exophytic fashion. CASE REPORT: A 35 year old female @entity1 presented to us with vague @entity490 . She had undergone excision of bilateral ovarian cystic masses for @entity44 twelve years earlier. A computed tomography scan of abdomen and pelvis showed a 9 x 7 cm uniformly solid mass with poor contrast enhancement situated in the inferomedial aspect of the left kidney. On exploration, the mass was arising from the inferior and anterior aspect of left renal pelvis, and was attached to it with a narrow pedicle. There was no adherence or attachment to the @entity8 . The mass was excised preserving the kidney. Microscopically, the @entity5 was composed of large collagenized areas containing bundles of spindle cells and several 'microcysts' lined by cuboidal epithelium suggestive of a benign mixed epithelial @entity5 . DISCUSSION: Mixed @entity5 usually present in perimenopausal @entity1 as a partially cystic mass. @entity5 are composed of irregular mixtures of cystic and solid areas, glands with variable complexity and distribution and the stromal component is characterized by a spindle cell proliferation. Commonly, it arises from the @entity8 and pelvis and nephrectomy is advocated to manage these @entity5 . CONCLUSION: @entity5 is a distinctive @entity703 that should be distinguished from other @entity703 . @entity5 arising from the renal pelvis and growing exophytically is a rare entity. The overall prognosis is favorable.

title: Benign mixed epithelial stromal XXXX with exophytic growth: case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal parenchyma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stromal tumor', 'tumor', 'Tumors', 'MEST', 'epithelial tumors', 'Mixed epithelial and stromal tumor', 'tumors']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['cystic teratoma']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal neoplasms', 'benign composite neoplasm of the kidney', 'benign tumor of the kidney']

answer: @entity703 :: (MESH:D007680,Disease) :: ['tumor of the renal pelvis']


abstract: An 18-year-old @entity1 with @entity12977 had sudden profound bilateral @entity227 , presumably as a result of @entity1188 caused by @entity417 and @entity551 from massive @entity360 . Her central visual acuity largely recovered in her right eye, but her left eye had only hand motions acuity. During the subsequent 24 years, she underwent three separate surgical procedures for @entity360 . Abdominal arterial angiography showed @entity438 . A subtotal gastrectomy was done, and histopathologic examination found advanced degenerative changes of the elastic lamina of the gastric arteries. At age 42 years, the @entity1 lost residual vision in her right eye. This was caused by an extrafoveal subretinal @entity1940 , which was obliterated with laser photocoagulation. Degeneration of elastic tissue, the primary defect in this syndrome, may cause @entity65 and formation of breaks in the Bruch membrane, which are visible as @entity12978 . Ingrowth of fibrovascular tissue through @entity12978 may cause disturbances of macular function. The @entity6810 and @entity1188 associated with the profound @entity227 in this @entity1 reminds the ophthalmologist of the systemic nature of this disorder and the possibility that @entity455 with massive @entity190 may occur.

title: XXXX associated with @entity12977 .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['systemic vascular complications']

entities_list: @entity1940 :: ('MESH:D020256', 'Disease') :: ['choroidal neovascular membrane']

entities_list: @entity6810 :: ('MESH:D018917', 'Disease') :: ['optic nerve ischemia']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity12978 :: ('MESH:D000793', 'Disease') :: ['angioid streaks']

entities_list: @entity12977 :: ('MESH:D011561', 'Disease') :: ['pseudoxanthoma elasticum']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['optic nerve infarction', 'infarction']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular complications']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['numerous aneurysms of the gastric arteries']

answer: @entity227 :: (MESH:D014786,Disease) :: ['Visual loss']