abstract: BACKGROUND: The aim of this study was to show, whether a certain prophylacting applicable radiation affects the cognition, particularly, the specific cognitive components P50, N100, P300 and N400 of auditory event related potentials (ERPs) during a short memory test. METHODS AND MATERIALS: Eleven @entity1 with @entity151 ( @entity151 ), who had presented complete response of disease after chemotherapy and radical radiotherapy in the lung, were prescribed to receive a prophylacting cranial irradiation (PCI) with a 6 MeV linear accelerator. The dose schedule was consisting of a total dose up to 30 Gy in 10 fractions, within 12 days (5 days a week). The psychophysiological approach before and after PCI was assessed by measurements of the auditory ERPs during a short memory performance using the digit-span Wechsler test. Components of ERP were recorded from 15 scalp electrodes. Additionally, symptomatology of @entity308 and @entity148 were assessed using Zung Self-Rating @entity308 Scale and Spielberger Anxiety Inventory, respectively, for pre- and post-PCI. RESULTS: No significant difference was noticed pre- and post-radiotherapy of all particular level of psychophysiological analysis concerning both the latencies and the amplitudes of ERPs auditory components P50, N100, P300 and N400 (P > 0.05, Wilcoxon signed test). Additionally, no changes were found with regard to behavioral performance (memory recall), @entity308 symptomatology and state @entity148 , according to pre- and post-radiation measurements. However, the self-reported @entity308 symptomatology showed that the @entity1 presented moderate @entity308 . CONCLUSION: No short-term psychophysiological @entity2359 was detected with this PCI schedule using these instruments, lending additional support to evidence suggesting the benefit of this certain PCI schedule for @entity1 with @entity151 .

title: Psychophysiological evaluation of short-term @entity2359 after prophylactic brain irradiation in XXXX with @entity151 : a study of event related potentials.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['SCLC', 'small cell lung cancer']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity12359 (5'NT) activity of peripheral blood (PB) lymphocytes was determined in 31 patients with serum @entity1581 ( @entity1581 ). Twenty-one @entity1 had a diagnosis of @entity1582 ( @entity1582 ), and ten patients had @entity8058 ( @entity8058 ). The proliferative activity of the bone marrow plasma cells ( @entity3162 %) was investigated in 28 of these @entity1581 @entity1 by means of tritiated @entity1014 uptake evaluated by simultaneous autoradiography and cytoplasmic immunofluorescence. 5'NT activity was significantly lower in @entity1581 @entity1 as compared with normal controls. @entity1582 @entity1 had lower 5'NT activity than @entity8058 @entity1 , but the difference was not significant. By contrast, @entity1582 had significantly higher @entity3162 % than @entity8058 @entity1 . There was a linear regression of 5'NT on @entity3162 % which was statistically significant: the higher the @entity3162 %, the lower the 5'NT. Because the @entity3162 % is an accurate prognostic and monitoring factor in @entity1581 , this correlation indicates that 5'NT may be of assistance in predicting the clinical progress of @entity1581 @entity1 . In seven MGs, the PB T and B lymphocytes were studied separately. The T cell subpopulation was 5'NT deficient compared to the normal controls, shown as a significant linear regression of T cell 5'NT on the @entity3162 %. This suggests that in @entity1581 there may be an alteration of nonneoplastic T lymphocytes correlated with @entity5 growth. The OKT8+ lymphocytes were mainly responsible for the 5'NT deficiency of unseparated T lymphocytes.

title: Decreased @entity12359 activity of peripheral blood lymphocytes in human @entity1581 : correlation with XXXX cell kinetics.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1581 :: ('MESH:D010265', 'Disease') :: ['monoclonal gammopathies', 'MG']

entities_list: @entity8058 :: ('MESH:D008998', 'Disease') :: ['MGUS', 'monoclonal gammopathy of undetermined significance']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']

entities_list: @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: Purpose of our study was to develop a reliable model to define clinical stage I nonseminomatous @entity2971 (NSGCT) being at low risk and at high risk for occult retroperitoneal metastases based on pathohistological and immunohistochemical parameters in order to stratify the therapeutic approach. 3-5 paraffin-embedded formalin fixed tissue blocks of 149 clinical stage I NSGCT were available from all @entity1 and were analyzed for histopathological features associated with pathological stage: presence/absence of vascular invasion, presence/absence of tunical invasion, percentage of each histological cell type present in the @entity5 . Immunohistochemical expression of @entity1758 , @entity876 , @entity588 , @entity10815 and @entity5962 was evaluated using a semiquantitative scoring ystem. Statistical analysis was performed by univariate and multivariate logistic regression models. Percentage of @entity189 [%EC (p < 0.001)] and presence of vascular invasion [VI (p < 0.0001)] were the most significant independent risk factors associated with pathological @entity34 . Combination of %EC and VI allowed correct prediction of final pathological stage in 88% of @entity1 . Cut-off values including both variables identified correct pathological stage in 131/149 @entity1 (88%). Less than 45% EC and absence of VI correctly identified pathological stage I disease in 91.5%; more than 80% EC and presence of VI correctly predicted pathological stage II in 88% of the @entity1 . %EC and presence/absence of VI appear to be reliable prognosticators to identify both @entity1 at high risk and at low risk for @entity66 . @entity876 , @entity588 , @entity1758 , @entity10815 and @entity5962 did not appear to be of prognostic value in clinical stage I NSGCT.

title: [Histopathologic and biological prognostic factors of clinical stage I non-seminomatous XXXX . Implications for risk-adjusted therapy].

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['occult retroperitoneal disease']

entities_list: @entity2971 :: ('MESH:D009373', 'Disease') :: ['germ cell tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['embryonal carcinoma']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II disease']

answer: @entity2971 :: (MESH:D009373,Disease) :: ['germ cell tumors']


abstract: A significant circadian rhythm of acute @entity137 was demonstrated in @entity19 with intraperitoneal (i.p.) injection of @entity1092 ( @entity2052 ). The role of pharmacokinetics on the rhythms of the @entity137 and electroshock seizure (ES) threshold was investigated. ICR male @entity19 , housed under a light-dark (12:12) cycle, were injected intraperitoneally 1200 mg/kg for the acute @entity137 study and 300 mg/kg for the anticonvulsant effect study. In the acute @entity137 , the highest mortality was found when @entity2052 was injected at 1700 and the lowest at 0900 or 0100. The time course of mean plasma and brain @entity2052 concentrations after an injection of @entity2052 was not different between @entity19 injected at 1700 and @entity19 injected at 0100. In the anticonvulsant effect, no significant circadian rhythm was demonstrated for both the ES threshold and the plasma @entity2052 concentrations after i.p. injection, although a significant rhythm has been reported for them after oral administration. The results suggest that the circadian rhythm in the mortality after an i.p. injection of @entity2052 may be due to the rhythm in the sensitivity of the central nervous system to the drug and that the mechanism underlying the rhythm of @entity2052 acute @entity137 is different from that of the anticonvulsant action of @entity2052 . The route and the time of drug administration are essentially important to study the anticonvulsant effect and acute @entity137 of @entity2052 in @entity19 .

title: Chronotoxicity of @entity1092 and its mechanisms in XXXX : dose-concentration-response relationship.

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['sodium valproate']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: In an effort to examine the potential clinical utility of intraperitoneal (i.p.) therapy in the management of @entity1 with @entity3620 , 19 individuals with this disease were treated with a @entity900 -based i.p. treatment regimen. All but 1 @entity1 also received i.p. mitomycin. The treatment was generally well tolerated, although a maximum of only four or five courses of @entity900 (100 mg/m2 every 28 days) and @entity1138 (5-10 mg/treatment given 7 days after each i.p. @entity900 administration) could be administered, the treatment principally being stopped because of disease progression or catheter failure. Of 15 @entity1 with @entity5 , 7 (47%) experienced control of fluid reaccumulation ranging from 2 months to 73+ months (median 8 months). While the median survival for the 19 @entity1 was only 9 months, 4 (21%) @entity1 survived for more than 3 years from the initiation of therapy, and 2 @entity1 are currently alive and clinically disease-free more than 5 years from the start of the i.p. treatment program. We conclude that a subset of @entity1 with peritoneal @entity2615 , principally those with small-volume @entity66 following surgical @entity5 debulking, can benefit from a @entity900 -based i.p. treatment strategy with control of ascites and prolonged disease-free survival.

title: Efficacy of XXXX -based intraperitoneal chemotherapy as treatment of @entity3620 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant ascites', 'tumor']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma']

entities_list: @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant peritoneal mesothelioma']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: @entity11 have been difficult to define and subsequently diagnose due to the paucity of literature specifically examining this group of @entity5 . Thirty @entity11 in which the minor glial component comprised at least 20% of the total @entity5 were studied: 20 @entity816 ( @entity816 ) and ten @entity5 ( @entity5 ). Nineteen @entity1 were male (mean age 36 years) and 19 @entity1 (63%) presented with @entity410 . The @entity5 was located in the frontal lobe in 17 @entity1 (57%) and the temporal lobe in nine @entity1 (30%). The duration of preoperative symptoms in 25 @entity1 ranged from five days to 14 years (mean 2.6 years). A mean follow-up of four years was available in 29 @entity1 . Fourteen @entity1 , seven with @entity816 and seven with @entity5 , had recurrent @entity5 . One @entity1 with @entity5 and four @entity1 with @entity816 (three with @entity5 progression and one with extensive leptomeningeal spread) died as a result of their @entity5 one to five years after diagnosis. Eighteen @entity1 received chemotherapy and/or radiation therapy. Twenty-five @entity5 were immunostained with antibody to @entity876 protein. @entity876 nuclear staining was seen in 5/16 @entity816 (31%) and 3/9 @entity5 (33%). Positive staining was observed only in astrocytic appearing cells. One of the four @entity1 who died with @entity816 was @entity876 positive. Three recurrent MOAs were @entity876 positive. Our study indicates that: 1. @entity11 most frequently occur in the frontal lobe and the majority of @entity1 present with @entity410 ; 2. there is no obvious association of @entity876 detection in @entity11 with @entity5 grade or behavior; and 3. similar to pure @entity816 , a subset of @entity816 and @entity5 may be associated with @entity876 alterations.

title: A clinicopathologic study of 30 cases of @entity816 including XXXX immunohistochemistry.

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'MOA', 'malignant oligoastrocytomas']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['Mixed gliomas', 'mixed gliomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['OA', 'fibrillary astrocytomas', 'oligoastrocytomas']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: It has been suggested that alterations of @entity1154 receptor sensitivity in the central nervous system may be associated with some forms of affective illness. It has been observed by several investigators that chronic treatment with antidepressant drugs causes down regulation of NE receptor coupled adenylate cyclase and beta adrenergic receptor binding in @entity35 brain. This observation has led to the suggestion that the therapeutic effects of antidepressant drugs may be related to the changes in the responsivity of beta adrenergic receptors. In order to examine if @entity308 may be associated with altered beta adrenergic function, we studied adenylate cyclase and its responsiveness to @entity1063 and @entity3044 in the leukocytes obtained from @entity1 with @entity146 and normal controls as an index of beta adrenergic receptor function. We also studied the effects of antidepressant drugs, in vitro, on @entity3044 sensitive leukocyte adenylate cyclase. We observed that @entity1063 and @entity3044 sensitive leukocyte adenylate cyclase in @entity308 @entity1 are significantly decreased as compared to normal controls. Our results appear to have been replicated by another group of investigators. We also observed that certain antidepressant drugs potentiate @entity3044 stimulated accumulation of @entity1919 in @entity1 leukocytes. This potentiation was most pronounced in the case of @entity42033 . These results thus indicated a decreased beta adrenergic receptor function in @entity1 with @entity308 . Whether or not such decreased receptor function is associated with @entity308 or is a manifestation of some other changes unrelated to the illness is not clear. Our results also indicate that some antidepressant drugs may enhance adrenergic transmission by potentiating the effects of neurotransmitters on beta adrenergic receptors.

title: Beta adrenergic receptor function in XXXX and the effect of antidepressant drugs.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive illness', 'depressed']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric illness']

entities_list: @entity42033 :: ('MESH:D007488', 'Chemical') :: ['iprindole']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

entities_list: @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP']

entities_list: @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamine']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: OBJECTIVE: To examine the relationship between leptin and @entity2690 serum levels and systolic and diastolic blood pressure in young @entity1 . SETTING: Kobe University of Mercantile Marine, Kobe, Japan. @entity1 : One hundred and ninety-eight male students aged 18-20 years (comprising 100% of those eligible). DESIGN AND MEASUREMENTS: A cross-sectional survey of a sample of male college students was performed, with measurements to include anthropometry, blood pressure and blood tests after overnight fasting. RESULTS: Compared with 90 @entity1 with an optimal blood pressure, 56 @entity1 with high-normal and high blood pressure had an increase in body mass index (23.7 +/- 5.2 versus 20.4 +/- 2.2 kg/m2), percentage body fat (21.7 +/- 8.0 versus 16.3 +/- 4.2%) and serum leptin (3.7 +/- 4.7 versus 1.5 +/- 0.8 ng/ml). In addition, they had greater serum @entity2690 (59 +/- 31 versus 43 +/- 12 pmol/l) despite there being no differences in plasma @entity413 , resulting in a reduction of the ratio of @entity413 to @entity2690 (107 +/- 43 versus 126 +/-, which is an estimate of @entity2690 sensitivity in a nondiabetic population. Furthermore, the 56 @entity1 had higher serum @entity412 levels, although there was no difference in low density lipoprotein- @entity165 and high density lipoprotein- @entity165 between @entity1 with optimal and high-normal plus high blood pressure. Similar differences were found between @entity1 in a top versus low tertile of systolic and diastolic blood pressure. In multiple regression analysis, both log leptin and log @entity2690 emerged as determinants for systolic blood pressure independent of body mass index and percentage body fat, but an association with diastolic blood pressure was only shown for log leptin. CONCLUSION: Hyperleptinemia and @entity3190 may be regulators of arterial pressure, independent of body mass index or percentage body fat.

title: Fasting XXXX and leptin serum levels are associated with systolic blood pressure independent of percentage body fat and body mass index.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'men']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity2690 :: (3630,Gene) :: ['insulin']


abstract: UNASSIGNED: @entity1669 ( @entity1669 ) including @entity2743 ( @entity2743 ) and @entity2621 ( @entity2621 ) are @entity74 . Cytokines @entity1356 and @entity3646 play a role in the pathogenesis of @entity1669 . This study was conducted on Tunisian @entity1 with @entity2743 or @entity2621 to investigate the association of @entity1356 and @entity3646 gene polymorphisms with the risk and the prognosis of @entity1669 . A total of 358 healthy controls and 341 @entity1 with AITDs (249 @entity2621 and 92 @entity2743 ) were genotyped for @entity1356 @entity40533 and @entity3646 intron 3 VNTR polymorphisms. A significant association was found between @entity1356 @entity40533 polymorphism and @entity2743 or @entity2621 , both in the dominant and additive models. The @entity1356 +3953T allele was associated with @entity2743 (p = 0.0003, OR = 1.93, CI = 1.34-2.78) and @entity2621 (p = 0.009, OR = 1.43, CI = 1.09-1.88). The @entity3646 VNTR polymorphism was associated only with @entity2621 risk both in additive (p = 0.03, OR = 0.31, CI = 0.11-0.86) and recessive (p = 0.03, OR = 3.04, CI = 1.13-8.17) models. No significant association was found between @entity1356 @entity40533 polymorphism and change in the serum concentrations of TSH and FT4 in @entity2743 and @entity2621 @entity1 . In @entity2621 @entity1 , the @entity1356 +3953T allele (p = 0.009, OR = 0.42, CI = 0.22-0.83) and the @entity1356 +3953T/T genotype (p = 0.03, OR = 0.21, CI = 0.04-1.07) were more frequent in the absence than in the presence of an anti-TPO antibody. The proportion of @entity2621 @entity1 with the P1P2 genotype of the @entity3646 gene was significantly higher in the absence than in the presence of the anti-TPO antibody (p = 0.04, OR = 0.39, CI = 0.17-0.89). These preliminary results suggest that @entity1356 and @entity3646 gene polymorphisms may be associated with @entity2743 and @entity2621 susceptibility and may represent prognostic factors for predicting the severity of @entity2621 .

title: Association of @entity1356 and XXXX Gene Variants with Autoimmune Thyroid Diseases in Tunisian Population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['AITD', 'Autoimmune thyroid diseases']

entities_list: @entity2621 :: ('MESH:D050031', 'Disease') :: ['HT', "Hashimoto's thyroiditis"]

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease", 'GD']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['complex genetic diseases']

answer: @entity3646 :: (3565,Gene) :: ['Interleukin-4']


abstract: BACKGROUND: @entity2737 and other hospital-acquired @entity281 cause significant morbidity after internal fixation of @entity174 (osteosynthesis). The administration of antimicrobial agents (antibiotics) may reduce the frequency of @entity281 . OBJECTIVES: To determine whether the prophylactic administration of antibiotics in @entity1 undergoing surgical management of @entity174 reduces the incidence of wound and other hospital acquired @entity281 . SEARCH STRATEGY: We searched the The Cochrane Library, Issue 3 2000; MEDLINE, EMBASE, LILACS, Current Contents, Dissertation Abstracts, and Index to UK Theses to August 2000. Bibliographies of identified articles were screened for further relevant trials. No language restriction was applied. SELECTION CRITERIA: Randomised or quasi-randomised controlled trials involving - @entity1 : Any @entity1 with a hip or other closed long @entity174 undergoing surgery for internal fixation or replacement arthroplasty. INTERVENTIONS: Any regimen of systemic antibiotic prophylaxis administered at the time of surgery. OUTCOME MEASURES: @entity2737 (deep and superficial), @entity293 , @entity1729 , adverse effects of prophylaxis, economic evaluations. DATA COLLECTION AND ANALYSIS: Two reviewers independently screened papers for inclusion, assessed trial quality using an eight item scale, and extracted data. Additional information was sought from two trialists. Pooled data are presented graphically. MAIN RESULTS: Data from 8307 @entity1 in 22 studies were analysed. In @entity1 undergoing surgery for closed @entity174 fixation, single dose antibiotic prophylaxis significantly reduced deep wound @entity281 (relative risk 0.40, 95%CI 0.24, 0.67) superficial wound @entity281 , @entity293 , and @entity1729 . Multiple dose prophylaxis had an effect of similar size on deep wound @entity281 (relative risk 0.40, 95%CI 0.24, 0.67), but significant effects on urinary and @entity1729 were not confirmed. Economic modelling using data from one large trial indicates that single dose prophylaxis with @entity2756 is a cost-effective intervention. There are limited data for the incidence of adverse effects, but as expected they appear to be more common in those receiving antibiotics, compared with placebo or no prophylaxis. REVIEWER'S CONCLUSIONS: Antibiotic prophylaxis should be offered to those undergoing surgery for closed @entity174 fixation. On ethical grounds, further placebo controlled randomised trials of the effectiveness of antibiotic prophylaxis in closed @entity174 surgery are unlikely to be justified. Trials addressing the cost-effectiveness of different effective antibiotic regimens would need to be very large.

title: Antibiotic prophylaxis for surgery for proximal femoral and other closed long XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'bone fracture', 'hip or other long bone fractures']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections', 'respiratory tract infection', 'respiratory infections']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection', 'urinary infections']

answer: @entity174 :: (MESH:D050723,Disease) :: ['bone fractures']


abstract: OBJECTIVE: To establish a description of the @entity146 population of the Instituto Nacional de Perinatolog  a (INPer), as well as of the exposed newborns to psychopharmacological treatment during the gestation. MATERIAL AND METHOD: One hundred forty-six @entity1 were gathered, by means of serial files; 85 of them had an @entity2143 episode of high risk and 61 were assisted in the institution due to gynecological alterations. A clinical psychologist and a psychiatrist carried out, each one, an interview and the clinical history of all the @entity1 . Once the type diagnosis was determined (DSM-IV), they received psicotherapeutical, pharmacological or mixed treatment, until the resolution of the @entity2143 episode and the gathering of the neonatal data. RESULTS: The findings reported that the prevalence or @entity146 (DSM-IV) that are not adaptive at the INPer is 1.8%. The diagnostic distribution of the @entity146 population ranked in first place the @entity1316 (63.7%), particularly major @entity308 (42.5%). These percentages correspond at the institutional total population's 1.19 and 0.79. As for the treatment type, 57 @entity1 received psychotherapy, 75 received psychopharmacological treatment and 14 received both treatments. The newborn babies of @entity2143 @entity1 who received psychopharmacological treatment did not show differences in Apgar, weight, size, complications or @entity2143 resolution in comparison with @entity1 who received psychotherapy and again with respect to institutional media. DISCUSSION: The prevalence found in the Institution is significantly inferior to that reported at a national and global level, due to the use of two diagnostic interviews by mental health specialists. The wrong use of the sieve is one of the reasons for overdiagnosis in mental health.

title: [A descriptive study of XXXX population at Instituto Nacional de Perinatolog  a].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders', 'psychiatric']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders']

entities_list: @entity2143 :: ('MESH:D048949', 'Disease') :: ['obstetric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: PURPOSE: To compare the clinical-pathological features of @entity1 with @entity43 and to identify the factors associated with survival. METHODS: In this reconstructed cohort study, 152 @entity1 with @entity43 , who attended medical consultations between 1993 and 2008 and who were followed-up until 2010 were included. The histological type was clearly established for all @entity1 : 81 serous @entity189 and 71 non- @entity5 (17 endometrioid, 44 mucinous and 10 @entity1358 ). The crude and adjusted odds ratios (OR), with the respective 95% confidence intervals (95%CI), were calculated for the clinical and pathological features, comparing serous and non-serous histological types. The Hazard Ratios (HR) with 95%CI was calculated for overall survival, considering the clinical and pathological features. RESULTS: Comparison of serous to non-serous @entity5 types by univariate analysis revealed that @entity5 were more frequently found in postmenopausal @entity1 , and were predominantly high histological grade ( @entity20064 ), advanced stage, with @entity10224 >250 U/mL, and with positive peritoneal cytology. After multivariate regression, the only association remaining was that of high histological grade with @entity5 (adjusted OR 15.1; 95%CI 2.9-77.9). We observed 58 deaths from the disease. There was no difference in overall survival between @entity1 with @entity189 and @entity1 with @entity189 (HR 0.4; 95%CI 0.1 - 1.1). It was observed that @entity1 aged 50 years or less (HR 0.4; 95%CI 0.1-0.9) and those who were in menacne (HR 0.3; 95%CI 0.1-0.9) had a longer survival compared respectively to those above 50 years of age and menopaused. High histological grade ( @entity20064 ) (p<0.01), stages II-IV (p<0.008) and positive cytology (p<0.001) were significantly associated with worse prognosis. @entity10224 and the presence of ascites did not correlate with survival. Survival was poor when the disease was diagnosed in stages II to IV and compared to stage I (log-rank p<0.01) regardless of histological type (serous and non-serous). CONCLUSIONS: The proportion of high histological grade ( @entity20064 ) was significantly higher among @entity189 . Serous and non-serous histological types were not related to overall survival.

title: [Serous and XXXX : histological @entity5 type as related to the grade of differentiation and disease prognosis].

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'serous and non-serous ovarian tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'serous tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['serous carcinoma', 'carcinomas', 'non-serous carcinoma', 'serous than non-serous carcinomas']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear cell carcinomas']

answer: @entity43 :: (MESH:D010051,Disease) :: ['non-serous ovarian carcinoma']


abstract: OBJECTIVE: @entity0 ( @entity0 ) after mastectomy has been hypothesized to represent a complex psychological reaction to mastectomy, but psychological studies concerning @entity0 are few and inconclusive. This study aimed to assess possible correlations of @entity0 to current psychopathology and personality dimensions, as well as to examine subjectively experienced provoking and relieving factors for the experience of @entity0 . METHOD: A total of 105 @entity1 who had undergone modified radical mastectomy were interviewed by a structured questionnaire after breast surgery. Moreover, they completed a set of self-administered psychometric scales consisting of Symptom Checklist-90-R, Eysenck personality questionnaire, Zung @entity308 scale, State-Trait @entity148 Inventory and Whiteley Index of @entity16251 . RESULTS: @entity0 was experienced by 24 @entity1 (22.9%). The majority of them thought that @entity0 did not interfere with their everyday life. @entity1 with @entity0 scored significantly higher on the Zung @entity308 scale. Multiple logistic regression analysis revealed that @entity1 aged more than 66 years were 82% less likely to have @entity0 compared to those aged less than 51 years. CONCLUSION: These findings provide evidence that @entity0 is associated with higher scores of depressive symptomatology and younger age. The nature of such an association remains unclear and calls for further investigation.

title: Depressive symptomatology correlates with phantom breast syndrome in mastectomized XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Phantom breast syndrome', 'PBS']

entities_list: @entity16251 :: ('MESH:D006998', 'Disease') :: ['hypochondriasis']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: AIM: To assess the efficacy of percutaneous @entity10545 treatment using a combination of radiofrequency ablation (RFA) and @entity167 ablation with regard to technical and long-term clinical success. MATERIALS AND METHODS: From December 2001 to November 2004, RFA and subsequent @entity167 ablation was performed on 54 @entity1 with @entity10545 , diagnosed clinically using radiography, computed tomography (CT) and symptoms. Under general anaesthesia, treatment was performed via percutaneous access under thin section (2mm) spiral CT guidance in all cases with an 11 G radiofrequency-compatible coaxial needle and 2mm coaxial drill system and 1.0 cm active tip 17 G non-cooled radiofrequency needle. RFA was performed at 90 degrees C for a period of 6 min. After needle removal, 0.5-1.0 ml absolute @entity167 (99.8% concentration) was injected directly into the nidus using a 20 G needle. @entity1 were discharged within 24h and followed up clinically (at 1 week, 1 month and every 3 months thereafter). RESULTS: The technical success rate was 100%. Complications occurred in two @entity1 consisting of local mild @entity2688 in entry site and peripheral small zone paresthesia on the anterior part of leg. The follow-up period range was 13-48 months (mean+/-SD, 28.2+/-7.4 months). Prompt @entity158 relief and return to normal activities were observed in 52 of 54 @entity1 . Recurrent @entity158 occurred in two @entity1 after a 1 and 3 months period of being @entity158 free, respectively; a second RFA and @entity167 ablation was performed achieving successful results. Primary and secondary clinical success rates were 96.3% (52/54 @entity1 ) and 100% (2/2 @entity1 ), respectively. CONCLUSION: @entity10545 treatment with combination of radiofrequency and @entity167 ablation is safe, effective and minimally invasive with high primary and secondary success rates. Persistent or recurrent lesions can be effectively re-treated.

title: XXXX treatment with combination of radiofrequency and @entity167 ablation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity2688 :: ('MESH:D002481', 'Disease') :: ['cellulitis']

entities_list: @entity10545 :: ('MESH:D010017', 'Disease') :: ['osteoid osteoma', 'Percutaneous osteoid osteoma']

answer: @entity10545 :: (MESH:D010017,Disease) :: ['Percutaneous osteoid osteoma']


abstract: OBJECTIVE: To evaluate the effect and possibility of surgical ablation of the pulmonary vein orifices under direct vision with transballoon ultrasound ablation catheter for @entity1 with permanent @entity955 and @entity627 . METHODS: 21 consecutive @entity1 with @entity627 and permanent @entity955 undergoing mitral valve replacement surgery were enrolled for this study from December 2002 to September 2003. All the cases were divided into 2 groups by whether or not receiving an additive pulmonary vein ablation procedure. The test group [6 male, 5 female, aged (51.55 +/- 7.83) years, @entity955 duration (5.50 +/- 5.40) years, left atrial diameter (7.27 +/- 1.39) cm, LVEF (53.95 +/- 4.54)% and NYHA class II - IV] undertook a surgical isolation of the pulmonary vein orifices by using a transballoon ultrasound ablation catheter addition to routine mitral valve replacement. The control group [3 male, 7 female, aged (53.30 +/- 7.86) years, @entity955 duration (4.50 +/- 3.47) years, left atrial diameter (6.74 +/- 0.62) cm, LVEF (56.91 +/- 3.78)% and NYHA class II - IV] received the valve replacement surgery alone. RESULTS: There were not any complications in both groups. With an electrical cardioversion 3 months after the surgery, 73% @entity1 in the ultrasound ablation group were free from AF over 1 year while only 10% @entity1 in control group (P=0.003). During an average follow-up duration of (45.92 +/- 4.61) months, 63.6% were in sinus rhythm in ultrasound ablation group while none in the control group. Left atrial volume decreased significantly at 1 year after surgery compared to that at 3 months after surgery in the test group [(97.83 +/- 32.39) cm(3) vs. (150.78 +/- 52.32) cm(3), P<0.05], and the end systolic diameter (LAESD) and end diastolic diameter (LAEDD) also decreased [(4.12 +/- 0.39) cm vs. (5.09 +/- 0.98) cm, P<0.05, respectively], while there were no apparently changes in the control group. CONCLUSIONS: Ablation of the orifices of the pulmonary veins under direct vision with transballoon ultrasound ablation catheter during mitral valve surgery seems effective to maintain sinus rhythm after electrical cardioversion and could be performed safely. The function of left atrial and cardiac output improved during long term follow-up of 46 months.

title: [Ablation of the orifices of the pulmonary veins under direct vision by using the transballoon ultrasound ablation catheter for permanent @entity955 with XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic valve disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

answer: @entity627 :: (MESH:D012216,Disease) :: ['rheumatic valve disease']


abstract: OBJECT: It has been established that @entity2518 ( @entity2518 ) induces the accumulation of fluorescent @entity7889 in @entity463 ( @entity463 ), a phenomenon potentially exploitable to guide @entity5 resection. In this study the authors analyze the influence of fluorescence-guided resection on postoperative magnetic resonance (MR) imaging and survival in a series of @entity1 who underwent surgery in the authors' department. METHODS: Fifty-two consecutive @entity1 with @entity463 received oral doses of @entity2518 (20 mg/kg body weight) 3 hours before induction of anesthesia. Intraoperatively, @entity5 fluorescence was visualized using a modified operating microscope. Fluorescing tissue was removed whenever it was considered safely possible. Residual enhancement on early postoperative MR imaging was quantified and related to each @entity1 's characteristics to determine which factors influenced resection. Survival was analyzed using the Kaplan-Meier method and multivariate analysis was performed in which the Karnofsky Performance Scale (KPS) score, residual fluorescence, @entity1 age, and residual enhancement on MR images were considered. Intraoperatively, two fluorescence qualities were perceived: solid fluorescence generally reflected @entity5 , whereas vague fluorescence mostly corresponded to infiltrative @entity5 . Complete resection of contrast-enhancing @entity5 was accomplished in 33 @entity1 (63%). Residual intraoperative tissue fluorescence left unresected for safety reasons predicted residual enhancement on MR images in 18 of the 19 remaining @entity1 . Age, residual solid fluorescence, and absence of contrast enhancement in MR imaging were independent explanatory factors for survival, whereas the KPS score was significant only in univariate analysis. No perioperative @entity204 and one case of permanent morbidity were encountered. CONCLUSIONS: The observations in this study indicate the usefulness of @entity2518 -induced @entity5 fluorescence for guiding @entity5 resection. The completeness of resection, as determined intraoperatively from residual tissue fluorescence, was related to postoperative MR imaging findings and to survival in @entity1 suffering from @entity463 .

title: Fluorescence-guided resection of @entity463 by using XXXX -induced @entity7889 : a prospective study in 52 consecutive @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'coalescent tumor']

entities_list: @entity7889 :: ('MESH:D011166', 'Chemical') :: ['porphyrins']

entities_list: @entity2518 :: ('CHEBI:17549', 'Chemical') :: ['5-ALA', '5-aminolevulinic acid']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GBM']

answer: @entity2518 :: (CHEBI:17549,Chemical) :: ['5-aminolevulinic acid']


abstract: BACKGROUND: @entity4340 remains a rare condition. Together with a decreasing incidence of @entity378 , @entity4340 ( @entity4340 ) has become relatively more frequent and represents more than half of iliopsoas abscesses. OBJECTIVE: To analyze presentation, treatment, and outcomes in a series of @entity1 with diagnosis of @entity4340 . DESIGN: Retrospective. SETTINGS: A single tertiary care institution. @entity1 : A series of 34 consecutive @entity1 with diagnosis of @entity4340 treated between 2001 and 2010 at the Hospital Italiano de Buenos Aires. MAIN OUTCOME MEASURES: Analyzed variables were: age, sex, diagnostic modality, clinical presentation, and treatment outcomes. RESULTS: Primary and secondary abscess occurred in 20.6% and 79.4%, respectively. The leading cause of @entity4340 was @entity1512 (38%) and computed tomography was the preferred diagnostic modality (87%). Most common presentation was left unilateral abscess in 66% of @entity1 and most frequent isolated bacteria were @entity794 . Fifteen @entity1 (44%) received antibiotics as initial treatment with an initial failure rate of 80%; 11 of 15 @entity1 required a second treatment. Sixteen @entity1 (47%) underwent @entity5173 ( @entity5173 ) as first line treatment with a success rate of 50%. However, success rate of @entity5173 , increased to 100% after 2 drainages. Three @entity1 were surgically drained without success (0 of 3 @entity1 ). Compared with the rest of the population, @entity5173 showed a lower hospital stay (25 vs. 14 d, respectively, P = 0.08) whereas surgery had a higher mortality rate (8% vs. 22%, respectively, P = 0.03). LIMITATIONS: A single institutional retrospective study. CONCLUSIONS: Our series showed a higher proportion of unilateral and secondary abscess. @entity1512 was the first cause of @entity4340 . @entity5173 seems to be the best treatment option for @entity4340 and compared with surgery it is associated with a higher success rate and lower hospital stay and mortality rate.

title: XXXX : presentation, management, and outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity1512 :: ('MESH:D015299', 'Disease') :: ['Spondylodiscitis', 'spondylodiscitis']

entities_list: @entity4340 :: ('MESH:D016659', 'Disease') :: ['PIPA', 'pyogenic iliopsoas abscess', 'Iliopsoas abscess']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity5173 :: ('MESH:D065634', 'Disease') :: ['percutaneous drainage', 'PD']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis infection']

answer: @entity4340 :: (MESH:D016659,Disease) :: ['Iliopsoas abscess']


abstract: BACKGROUND: @entity117 ( @entity1281 ) and @entity1229 are used to prevent @entity63 cerebrovascular events. They have serious complications including @entity932 ( @entity932 ). @entity1229 -related @entity1779 ( @entity1779 ) incidence is .2%-5% in population that accounts for 10%-12% of all ichs. In this article, we investigated the profile of @entity1281 and @entity1229 -related spontaneous @entity932 in comparison with @entity932 @entity734 ( @entity734 ) with their clinical, radiological, and biochemical properties. METHODS: In all, 486 @entity1 aged 18-101 years with spontaneous @entity932 were included. @entity1 constituted 4 separate groups: users of @entity1229 , @entity1281 , @entity1281 + @entity1229 , and @entity734 . Clinical, neurological, etiological, and radiological data of these @entity1 were compared. RESULTS: There were 32 @entity1 in @entity1229 , 58 @entity1 in @entity1281 , and 7 in @entity1229 + @entity1281 group. Most of the @entity1 were in no drug group (389 @entity1 ). The most frequent type of @entity548 was @entity548 . The most common accompanying disease was @entity101 . The number of female @entity1 was statistically significant in the @entity1229 group. Glasgow @entity772 Scale (GCS), accompanying diseases, opening of the @entity1410 to the ventricle, localization of the @entity548 , age of the @entity1 , and activated partial thromboplastin time level are all related to the outcome of @entity1 . @entity1229 users had worst mortality rate. CONCLUSIONS: Use of @entity1229 , low GCS score, opening to ventricle, older age, accompanying @entity6 , and/or @entity101 were worse prognostic factors. It is possible that @entity1 with these unfavorable prognostic factors cannot survive.

title: @entity932 related with @entity1229 use and comparison of XXXX and @entity117 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhages', 'ICHs']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'supratentorial intraparenchymal hemorrhage']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['Acetylsalicylic acid']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['WADU', 'without any drug use']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['ich', 'intracerebral hemorrhage']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['Warfarin', 'warfarin']

answer: @entity1229 :: (MESH:D014859,Chemical) :: ['warfarin']


abstract: We describe the aetiology of community-acquired @entity55 in @entity1 before and after the introduction of the pneumococcal conjugate vaccination ( @entity1485 ) programme in 2006. Prospective studies were conducted in 2001-2002 (pre-vaccine) and 2009-2011 (post-vaccine) of @entity1 aged 0-16 years with radiologically confirmed @entity55 seen in hospital. Investigations included culture, serology, immunofluorescence antibody and urine antigen testing, with an increased use of PCR assays and expanded panels of pathogens in the post-vaccine study. 241 and 160 @entity1 were enrolled in the pre- and post-vaccine studies, respectively (73% aged <5 years). Identification of a causative pathogen was higher post-vaccination (61%) than pre-vaccination (48.5%) (p=0.019). Rates of @entity2348 were not different between post- and pre-vaccine studies (17.5% versus 24%, p=0.258). Viral (31%) and mixed (12.5%) infections were found more often post-vaccination (19.5%, p=0.021) than pre-vaccination (5%, p=0.015). Rates of identified @entity7706 were comparable between pre- and post-vaccine studies (14.7% versus 17.4%, p=0.557). Diagnosis of @entity7706 post-vaccination improved when PCR was used compared to culture (21.6% versus 6%, p=0.0004). Serotypes included in PCV13 but not PCV7 were identified in 75% (18 out of 24) post-vaccination. Infection with nonvaccine pneumococcal serotypes continues to be a significant cause of @entity55 in @entity1 in the UK.

title: Aetiology of paediatric XXXX after the introduction of pneumococcal conjugate vaccine.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity7706 :: ('MESH:D011008', 'Disease') :: ['pneumococcal infection', 'pneumococcal infections']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections']

answer: @entity55 :: (MESH:D011014,Disease) :: ['pneumonia']


abstract: Background. @entity2210 ( @entity2210 ) is a functional upper @entity344 with significant morbidity and medical costs. Previous studies investigated the association of @entity14644 ( @entity14644 ) genetic polymorphisms with @entity2210 but with inconsistent results. Therefore, we performed a meta-analysis to derive a precise estimation of the relationship between @entity14644 polymorphisms and @entity2210 . Methods. We searched different databases including PubMed, EMBASE, CNKI, and the Ovid Library to gather eligible studies on @entity14644 polymorphisms and @entity2210 . The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Results. We identified 12 studies with 1109 cases and 2853 controls for the analysis. We found no associations of @entity14644 @entity14643 polymorphism with @entity2210 in the overall population (T versus C, OR = 1.06, 95% CI: 0.96-1.18, P = 0.26; TT versus CC + CT, OR = 1.16, 95% CI: 0.97-1.39, P = 0.11; TT + CT versus CC, OR = 1.01, 95% CI: 0.77-1.31, P = 0.96; TT versus CC, OR = 1.15, 95% CI: 0.93-1.44, P = 0.20). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07-2.24, P = 0.02). Sensitivity analysis did not reveal significant associations under all models. Conclusions. This meta-analysis demonstrates that @entity14644 @entity14643 polymorphism may not be a risk factor for @entity2210 .

title: The XXXX Polymorphism of the @entity14644 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis.

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorder']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['Functional dyspepsia', 'FD']

answer: @entity14643 :: (c|SUB|C|825|T,DNAMutation) :: ['C825T']


abstract: BACKGROUND: A multimodality approach for locally recurrent @entity14 in the pelvis provides a significant survival advantage when negative margins are achieved. However, outcomes of surgical resection in @entity1 who have locally re-recurrent disease in the pelvis are not well studied. Our aim was to assess the safety, feasibility of a negative margin resection, and survival outcomes in @entity1 with pelvic locally re-recurrent @entity14 . DESIGN: A retrospective review identified 406 @entity1 who underwent surgery for locally recurrent @entity14 between 1997 and 2007. @entity1 who had locally re-recurrent disease in the pelvis who underwent curative-intent resection were identified. RESULTS: Forty-seven @entity1 (31 male) were identified. Median age was 57 years (range, 30-84 years). Median time to re-recurrence was 2.4 years (range, 0.5-5.6 years). Margin status following re-resection was R0 60%, R1 32%, and R2 8%. Nonbowel organs were resected en bloc in 81%, including 7 sacral resections. Intraoperative radiation was given to 77%. Morbidity occurred in 42%, with 6% requiring reoperation for complications. Thirty-day mortality was nil. Overall survival at 2 and 5 years was 83% and 33%. Disease-free survival at 2 and 5 years was 55% and 27%. Five-year survival for @entity1 who had R0 and R1 resections was 37% and 42%, whereas no @entity1 having an R2 resection survived beyond 2 years (p = 0.002). CONCLUSIONS: In highly selected @entity1 with re-recurrent @entity14 in the pelvis, we found that surgery could be performed safely and that a curative (R0) resection was possible in more than 50%. Two- and 5-year survival rates are comparable to results seen when surgery is done for first-time recurrences.

title: Is curative resection and long-term survival possible for locally re-recurrent XXXX in the pelvis?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: BACKGROUND: The objective of the study was to identify factors predictive of 6-month institutionalization or mortality in frail elderly @entity1 after acute hospitalization. METHODS: A prospective cohort of elderly subjects 75 years and older was set up in nine French teaching hospitals. Data obtained from a comprehensive geriatric assessment were used in a Cox model to predict 6-month institutionalization or mortality. Institutionalization was defined as incident admission either to a nursing home or other long-term care facility during the follow-up period. RESULTS: Crude institutionalization and @entity204 rates after 6 months of follow-up were 18% and 24%, respectively. Independent predictors of institutionalization were: living alone (HR=1.83; 95% CI=1.27-2.62) or a higher number of @entity1 (HR=0.86; 95% CI=0.78-0.96), balance problems (HR=1.72; 95% CI=1.19-2.47), @entity3147 or risk thereof (HR=1.93; 95% CI=1.24-3.01), and @entity303 (HR=1.88; 95% CI=1.32-2.67). Factors found to be independently related to 6-month mortality were exclusively medical factors: @entity3147 or risk thereof (HR=1.92; 95% CI=1.17-3.16), @entity933 (HR=1.80; 95% CI=1.24-2.62), and a high level of comorbidity (HR=1.62; 95% CI=1.09-2.40). Institutionalization (HR=1.92; 95% CI=1.37-2.71) and unplanned readmission (HR=4.47; 95% CI=3.16-2.71) within the follow-up period were also found as independent predictors. CONCLUSION: The main factors predictive of 6-month outcome identified in this study are modifiable by global and multidisciplinary interventions. Their early identification and management would make it possible to modify frail elderly subjects' prognosis favorably.

title: Six-month outcome of elderly XXXX hospitalized via the emergency department: the SAFES cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia syndrome']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: Upper extremity @entity4269 is a well-described complication of @entity0 treatment. Risk factors for @entity4269 development include @entity1600 ( @entity1600 ), @entity28 , increasing age, radiation, and @entity260 . In this study, we seek to evaluate a cohort of @entity1 who have either self-referred or been referred to the Department of Physical Therapy for @entity4269 treatment. Our goal is to evaluate specific risk factors associated with the severity of @entity4269 in this @entity1 population. METHODS: All @entity1 who presented to the Wexner Medical Center at the Ohio State University between January 1, 2009, and December 31, 2010, with a chief complaint of @entity2045 after @entity0 treatment were reviewed retrospectively. Upper extremity @entity4269 index (UELI) was used as a severity indicator and @entity1 factors including demographics and @entity0 treatments were evaluated. Univariate and multivariate statistical analyses were performed. RESULTS: Fifty (4.5%) @entity1 presented for @entity2045 treatment after @entity0 treatment (total of 1106 @entity1 treated surgically for @entity0 ). Greater UELIs were found in @entity1 50 years and older, those with @entity1600 , radiation, chemotherapy, pathologic stage greater than 3, and an International Society of Lymphology @entity4269 stage II (P < 0.05). The multivariate model showed age older than 50 years and pathologic stage greater than 3 were significant predictors of higher UELI (P < 0.05). CONCLUSIONS: In this study, we report that in @entity1 who present for @entity4269 treatment, increased UELI is significantly related to @entity1600 , radiation therapy, chemotherapy, age, and pathologic stage. An improved understanding of the @entity1 population referred for @entity4269 treatment will allow for the identification of @entity1 who may be candidates for therapeutic intervention.

title: Analysis of factors contributing to severity of XXXX -related @entity4269 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity lymphedema']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['axillary lymph node dissection', 'ALND']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: Many researchers have studied age- and sex-related differences in the management of @entity1 with @entity453 . However, the results are inconsistent. AIM: To assess sex- and age-related bias in the secondary prevention in @entity1 hospitalised due to @entity299 . METHODS: Five hospitals with departments of cardiology serving a city and surrounding districts in southern Poland participated in the study. Consecutive @entity1 hospitalised from 1 April 2005 to 31 July 2006 due to @entity1187 or for a myocardial revascularisation procedure and aged  <= 80 years were recruited and interviewed 6-18 months after hospitalisation. RESULTS: The hospital records of 640 @entity1 were reviewed and 513 (80.2%) @entity1 participated in the follow-up interview. @entity1 were older and less educated than their male counterparts. Sex was not independently associated with the control of major risk factors in the post-discharge period, whereas age was related to a higher probability of having @entity101 and a lower chance of smoking. Multivariate analysis showed that females were prescribed @entity460 antagonists (odds ratio [OR] 2.13; 95% confidence intervals [CI] 1.34-3.39) and diuretics (OR 1.52; 95% CI 1.00-2.31) more often than males. Age was independently related to the prescription rate of diuretics (>=  70 years vs. < 60 years; OR 1.61; 95% CI 1.19-2.20). The prescription rate of antiplatelets, beta-blockers, angiotensin converting enzyme-inhibitors/sartans, lipid-lowering drugs, and anticoagulants was not related to age or sex. CONCLUSIONS: We found no major sex-related difference in the frequency of achieving recommended goals in secondary prevention, whereas age was related to a lower prevalence of smoking and a higher probability of having @entity101 in subjects after hospitalisation for @entity453 .

title: Age, sex, and secondary prevention of XXXX in everyday practice.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Women']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['high blood pressure']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['ischaemic heart disease']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity299 :: (MESH:D006331,Disease) :: ['ischaemic heart disease']


abstract: PURPOSE: The use of shock waves in @entity66 was reviewed with special regard to the clinical applications. MATERIALS AND METHODS: Findings in the literature and results from our own studies were analyzed and summarized. RESULTS: Extracorporeal shock waves induced osteoneogenesis in animal models with intact and fractured bones. Based on these findings shock waves were used for the treatment of @entity1516 in @entity1 . Most @entity1 had at least 1 unsuccessful operation before shock wave therapy. Complete reunion was noted in 62 to 91% of cases and shock waves are recommended by some as the first choice of treatment for @entity1184 . After failed nonoperative therapy shock waves were used for the treatment of @entity1 with @entity66 as secondary treatment. The success rate for treatment of @entity924 , such as @entity2633 , @entity17126 humeroscapularis or @entity9066 , was approximately 80%. For @entity730 tendinitis shock wave therapy seems to be superior to all other minimal or noninvasive techniques without compromising a potential later operation. CONCLUSIONS: Shock waves have changed medical therapy substantially. Accounting for the epidemiology of the treated diseases, this new change may equal or even surpass the impact of extracorporeal shock wave lithotripsy.

title: Use of extracorporeal shock waves in the treatment of @entity1516 , XXXX and other @entity66 .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity17126 :: ('MESH:D010489', 'Disease') :: ['periarthritis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['orthopedic diseases', 'various diseases']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic pseudarthrosis']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinopathies']

entities_list: @entity9066 :: ('MESH:D036982', 'Disease') :: ['calcaneal spur']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcific']

entities_list: @entity2633 :: ('MESH:D013716', 'Disease') :: ['tennis elbow']

entities_list: @entity1516 :: ('MESH:D011542', 'Disease') :: ['pseudarthrosis']

answer: @entity924 :: (MESH:D052256,Disease) :: ['tendinopathy']


abstract: PURPOSE: To report the incidence, characteristics, and management of @entity2694 , a complication of orbital exenteration. DESIGN: Retrospective interventional case series. @entity1 : One hundred ten @entity1 who underwent orbital exenteration at 2 orbital units. METHODS: Retrospective chart review of all cases of orbital exenteration between 1993 and 2005 at one orbital unit and between 1999 and 2005 at a second orbital unit. MAIN OUTCOME MEASURES: Incidence of @entity2694 . RESULTS: Seventy-three and 37 orbital exenterations were performed at the first and second orbital units, respectively. Five @entity1 developed @entity2694 , 1 of whom developed 2 @entity292 at separate sites. In the first unit, 4 @entity292 developed in 3 of 73 (4.1%) @entity1 who underwent orbital exenteration. In the second unit, 2 @entity292 developed in 2 of 37 (5.4%) exenterated orbits. The majority (5/6) of @entity292 occurred medially to the ethmoid sinus, whereas 1 occurred superiorly to the frontal sinus. Risk factors that may have contributed to @entity292 formation include radiotherapy (3/6), @entity50 (3/6), intraoperative penetration into a sinus (3/6), and immunocompromise (1/6). Management was tailored to the individual case and ranged from conservative socket hygiene to surgical repair with grafts or flaps. Four of the 6 @entity292 recurred after repair. Three of these subsequently were closed successfully. Only 1 @entity292 persisted until the @entity1 died from @entity5 . CONCLUSIONS: Sino-orbital @entity292 are uncommon but not rare complications of orbital exenteration that may be predicted by several risk factors. Bothersome symptoms may necessitate treatment, which can range from conservative management to surgical repair with various grafts or flaps. Despite repair, @entity292 may be difficult to eradicate.

title: XXXX : a complication of exenteration.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease']

entities_list: @entity2694 :: ('MESH:D009916', 'Disease') :: ['sino-orbital fistulas']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula', 'fistulas']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['sinus disease']

answer: @entity2694 :: (MESH:D009916,Disease) :: ['Sino-orbital fistula']


abstract: PURPOSE: To determine optimal acquisition parameters and measurement techniques for CT angiography of the carotid bifurcation. METHODS: Anatomic phantoms were created in which the diameter of the carotid artery stenoses ranged from 15% to 95%. Initially, we compared the accuracy of @entity850 determination obtained by using various values of section collimation and table pitch. Subsequently, applying the combination of collimation and pitch that yielded the greatest longitudinal coverage without degradation in accuracy, we compared the accuracy of measurements performed with various display algorithms, including axial, magnified axial, @entity1213 ( @entity1213 ), and @entity11644 ( @entity11644 ) images. Last, we determined the effect on accuracy of varying both window and level settings. The standard of reference for all measurements was considered to be caliper measurements made of the models at the time of their construction. RESULTS: CT angiography was highly accurate for determining the percentage of @entity850 ; the average difference between CT angiographic measurements and the standard of reference was less than 1% for all parameter combinations and measurement techniques. Precision varied among the measurement techniques. Magnified axial images provided more precise measurements than either the @entity1213 or @entity11644 images. Although there was a trend toward improved precision with the use of magnified versus unmagnified axial images and @entity1213 versus @entity11644 images, neither of these comparisons reached statistical significance. Systematic error was produced by changing the level setting from that halfway between the luminal density and vessel wall density. Random error was introduced by using window settings greater than zero. CONCLUSION: CT angiography was highly accurate and precise for determining percentage of @entity850 . The highest precision was attained by using magnified axial images with the level halfway between luminal density and vessel wall density and with the window set to zero.

title: Accuracy and precision of CT angiography in a model of carotid artery bifurcation XXXX .

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1213 :: ('MESH:D012555', 'Disease') :: ['MIP', 'maximum intensity projection']

entities_list: @entity11644 :: ('MESH:C564120', 'Disease') :: ['SSD', 'shaded surface display']

answer: @entity850 :: (MESH:D003251,Disease) :: ['stenosis']


abstract: OBJECTIVE Because the metopic suture normally fuses during infancy, there are varying degrees of severity in @entity135 associated with premature fusion. A method for the objective and reproducible assessment of @entity91 is needed to guide management, as current methods are limited by their reliance on aesthetic markers. The object of this study was to describe the @entity12018 ( @entity12018 ), a simple anthropometric cranial measurement. The measurements can be obtained from CT scans and, more importantly, from palpable @entity129 , and the index provides a rapid tool for evaluating @entity1 in both pre- and postoperative settings. METHODS High-resolution head CT scans obtained in 69 @entity1 (age range 0-24 months) diagnosed with @entity12018 were retrospectively reviewed. Preoperative 3D reconstructions were available in 15 cases, and these were compared with 3D reconstructions of 324 CT scans obtained in a control group of 316 @entity1 (age range 0-24 months) who did not have any condition that might affect head size or shape and also in a subset of this group, comprising 112 @entity1 precisely matched to the @entity91 @entity1 with respect to age and sex. Postoperative scans were available and reviewed in 9 of the @entity91 @entity1 at a mean time of 7.1 months after surgical repair. 3D reconstructions of these scans were matched with controls based upon age and sex. RESULTS The mean preoperative @entity12018 for @entity1 with @entity91 was 0.48 (SD 0.05), significantly lower than the mean values of 0.57 (SD 0.04) calculated on the basis of all 324 scans obtained in controls (p < 0.001) and 0.58 (SD 0.04) for the subset of 112 age- and sex-matched controls (p < 0.001). For 7 @entity1 with both pre- and postoperative CT scans available for evaluation, the mean postoperative @entity12018 was 0.55 (SD 0.03), significantly greater than their preoperative MIs (mean 0.48 [SD 0.04], p = 0.001) and comparable to the mean @entity12018 of the controls (p = 0.30). In 4 @entity1 , clinically obtained postoperative MIs by caliper measurement were comparable to measurements derived from CT (p = 0.141). CONCLUSIONS The @entity12018 is a useful measurement of the severity of @entity91 in @entity1 with @entity91 . This simple quantitative assessment can potentially be used in the clinical setting to guide preoperative evaluation, surgical repair, and postoperative degree of correction.

title: The @entity12018 : an anthropometric index for the quantitative assessment of XXXX from @entity91 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head shape abnormalities']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial landmarks']

entities_list: @entity12018 :: ('MESH:C562951', 'Disease') :: ['metopic craniosynostosis', 'MI', 'metopic index']

entities_list: @entity91 :: ('MESH:D003398', 'Disease') :: ['craniosynostosis', 'metopic synostosis', 'trigonocephaly']

answer: @entity91 :: (MESH:D003398,Disease) :: ['trigonocephaly']


abstract: AIM: The aim of this study was to evaluate the safety of continuous nonabsorbable (3/0 @entity7502 ) sutures for @entity9876 , and the influence of induction chemotherapy on postoperative outcome in @entity1 with @entity358 . METHODS: A review of a prospective database of a single surgeon identified 41 consecutive @entity1 who underwent @entity9876 from May 1998 to July 2003. Bronchial reconstruction was done placing two 3/0 @entity7502 sutures at the far side of the cartilaginous wall and subsequently fixed. Afterwards, two running sutures were performed in order to obtain a telescopic @entity254 . RESULTS: Twenty-four @entity1 (59%) underwent induction chemotherapy. There were 31 right upper, 3 left lower ''reverse'', and 7 left @entity9876 with radical lymph node dissection. Eight @entity1 underwent reconstruction of the pulmonary artery. There were 34 @entity1149 , 3 limited @entity151 , 1 @entity152 , and 3 bronchial @entity5 . N2, N1, and N0 diseases were found in 13, 12 and 16 @entity1 , respectively. Post-operative morbidity and mortality were 14.5% (n=6) and 4.8% (n=2) (1 @entity1 , 4%, after induction chemotherapy). The rate of postoperative anastomotic complications was 2.4% (n=1). Late @entity850 developed in 3 cases, but all were successfully medically treated. Twenty-nine @entity1 are still alive, 27 without evidence of disease. The overall 2-year probability of survival (Kaplan-Meier) was 59%. Induction chemotherapy did not influence postoperative morbidity/mortality (chi2 test: P=0.64/P=0.56). CONCLUSIONS: Continuous nonabsorbable suture for @entity9876 is quick and technical easy to perform, with low postoperative morbidity/mortality; induction chemotherapy does not influence postoperative outcome in these @entity1 .

title: [Technique, results and impact of induction chemotherapy in XXXX for lung cancer].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['bronchial stenosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['carcinoid tumors']

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancers']

entities_list: @entity9876 :: ('MESH:D020232', 'Disease') :: ['upper sleeve lobectomies', 'sleeve lobectomy']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung malignancies']

entities_list: @entity152 :: ('MESH:D018287', 'Disease') :: ['neuroendocrine large cell carcinoma']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['small cell lung cancers']

answer: @entity9876 :: (MESH:D020232,Disease) :: ['sleeve lobectomy']


abstract: OBJECTIVE: To determine the effects of various concentrations of @entity9108 and @entity534 on in vitro replication of @entity29539 ). SAMPLE POPULATION: Cultured Crandell-Reese feline kidney ( @entity468 ) cells and FHV-1 strain 727. PROCEDURE: Uninfected @entity468 cells or @entity468 cells infected with FHV-1 were cultured in Dulbecco's modified Eagle's medium or in 1 of 7 test media containing various concentrations of @entity376 and @entity369 . Viral titer and CRFK growth rate were assessed in each medium. RESULTS: Media depleted of @entity369 almost completely inhibited viral replication, whereas 2.5 or 5.0 microg of @entity369 /ml of media was associated with a significant increase in FHV-1 replication. In media with 2.5 microg of @entity369 /ml, supplementation with 200 or 300 microg of @entity376 /ml reduced viral replication by 34.2 and 53.9%, respectively. This effect was not seen in media containing 5.0 microg of @entity369 /ml. Growth rates of @entity468 cells also were suppressed in media containing these concentrations of @entity1522 , but they were not significantly different from each other. CONCLUSIONS AND CLINICAL RELEVANCE: @entity369 exerts a substantial growth-promoting effect on FHV-1. Supplementation of viral culture medium with @entity376 attenuates this growth-promoting effect in media containing low concentrations of @entity369 . Analysis of data from this study indicates that high concentrations of @entity376 reduce in vitro replication of FHV-1 but only in media containing low concentrations of @entity369 . Clinical trials will be necessary to determine whether supplemental administration of @entity376 , with or without @entity369 restriction, will be useful in the management of @entity468 with FHV-1 infections.

title: Effects of @entity9108 and @entity534 on in vitro replication of XXXX .

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity29539 :: ('10334', 'Species') :: ['feline herpesvirus type-1 (FHV-1']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine', 'Arginine']

answer: @entity29539 :: (10334,Species) :: ['feline herpesvirus type-1']


abstract: AIM: Recent studies had suggested substantial molecular differences between @entity5 from different ethnic groups. In this study, the molecular differences between the incidences of @entity14 in Saudi and Swiss populations are investigated. METHOD: 518 cases of @entity5 (114 from Saudi Arabia and 404 from Switzerland) were analysed in a tissue microarray format. Fluorescence in situ hybridisation (FISH) was used to estimate frequencies of copy number changes of known oncogenes, including @entity1722 , TOPO2A, @entity4910 , @entity470 and @entity517 . RESULTS: Using FISH, amplifications were mostly low level (gene-to-centromere ratio 2 to 4), which is in contrast with other @entity5 types with more frequent gene amplifications. The amplifications were particularly frequent for MYC (Saudi 9% and Swiss 14.2%) but unrelated to clinical outcome and pathological information. Remarkably, there were four @entity5 exhibiting classic high-level gene amplification for @entity1722 (Swiss 1.3%), a pattern often accompanied by response to trastuzumab (Herceptin) in @entity0 . Occasional high-level amplifications were also observed for @entity4910 (Saudi 1/106, 0.9%; Swiss 2/373, 0.5%) and @entity470 (Swiss 2/355; 0.6%). CONCLUSIONS: Rare high-level amplifications of therapeutic target genes were found in @entity1 with @entity694 . Although no molecular differences were found between incidences of @entity694 cases in Swiss and Saudi populations, these observations emphasise the urgent need for clinical studies investigating the effect of targeted therapies.

title: @entity1722 , TOP2A, @entity4910 , @entity470 and @entity517 oncogene amplification in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'colon cancer tumours', 'tumours']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: Prognosis is known to be better in cases with isolated @entity2008 than in those with complex karyotypes. Accordingly, del(20q) as an @entity854 must be distinguished from cases in which it is associated with other chromosomal rearrangements for a better stratification of prognosis. We report a case of an isolated del(20q) abnormality with additional genomic aberrations identified using whole-genome single nucleotide polymorphism array (SNP-A)-based karyotyping. A 39-yr-old @entity1 was diagnosed with @entity3052 without @entity2175 . Metaphase cytogenetic analysis (MC) revealed del(20)(q11.2) as the @entity854 in 100% of metaphase cells analyzed, and FISH analysis using D20S108 confirmed the 20q deletion in 99% of interphase cells. Using FISH, other rearrangements such as BCR/ @entity1861 , @entity5316 / @entity10794 , PML/RARA, @entity17793 / @entity5400 , and @entity11626 were found to be negative. SNP-A identified an additional copy neutral loss of heterozygosity (CN-LOH) in the 11q13.1-q25 region. Furthermore, SNP-A allowed for a more precise definition of the breakpoints of the 20q deletion (20q11.22-q13.31). Unexpectedly, the terminal regions showed gain on chromosome 20q. The @entity1 did not achieve complete remission; 8 months later, he died from complications of @entity1778 cell infiltrations into the central nervous system. This study suggests that a presumably isolated @entity2008 by MC may have additional genomic aberrations, including CN-LOH, which could be associated with a poor prognosis. SNP-A-based karyotyping may be helpful for distinguishing true isolated cases from cases in combination with additional genomic aberrations not detected by MC.

title: Additional genomic aberrations identified by single nucleotide polymorphism array-based karyotyping in an XXXX case with isolated del(20q) abnormality.

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['maturation']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['isolated abnormality']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality', 'chromosomal abnormalities']

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']


abstract: @entity162 is a @entity1316 which requires complex treatment. Current treatment guidelines are based on the results of published randomized clinical trials and meta-analyses which may not accurately reflect everyday clinical practice. This multi-national, multi-centre, observational cohort study describes clinical management and clinical outcomes related to @entity162 in real-life settings, assesses between-country variability and identifies factors associated with clinical outcomes. Adults from 10 countries in Europe and South America who experienced at least one mood episode in the preceding 12 months were included. Overall, 2896 @entity1 were included in the analyses and followed for at least 9 months across a retrospective and prospective study phase. Main outcome measures were the number and incidence rate of mood episodes (relapses and recurrences) and healthcare resource use including pharmacological treatments. Relapses and recurrences were reported in 18.2 and 40.5% of @entity1 , respectively; however, the reported incidence rate of relapses was higher than that of recurrences [1.562 per @entity1 -year (95% CI 1.465-1.664) vs. 0.691 per @entity1 -year (95% CI 0.657-0.726)]. Medication use was high during all episode types and euthymia; the percentage of @entity1 receiving no medication ranged from 11.0% in @entity162 to 6.1% in euthymia. Antipsychotics were the most commonly prescribed drug class in all disease phases except for @entity1 with @entity308 , where antidepressants were more frequently prescribed. Visits to the psychiatrist were the most frequently used healthcare resource. These results provide a description of treatment patterns for @entity162 across different countries and indicate factors related to relapse and recurrence.

title: Clinical management and burden of XXXX : results from a multinational longitudinal study (WAVE-bd).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'mania', 'Bipolar disorder']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']


abstract: Twenty-five consecutive @entity1 with soft tissue @entity242 of the forearm and hand were assessed for limb-salvage surgery and were entered into a prospective study evaluating oncologic details and functional outcome. Seventeen @entity1 had received incomplete primary excision elsewhere and presented with local recurrence or @entity66 . Three had pulmonary metastases at the time of presentation. Twenty-three @entity1 were candidates for limb-salvage surgery and 20 received adjuvant radiotherapy. The mean follow-up period was 37 months. There was local recurrence in three @entity1 who had initially received marginal excision of the primary @entity242 , and three @entity1 died of @entity262 . Limb function was assessed prospectively using both @entity1 -based and clinician-based functional scoring systems and revealed good to excellent results in all but three @entity1 . Eighty-eight percent of those who survived and did not require amputation were able to return to occupational and activities of daily living with no or minimal functional limitation. This study demonstrates that limb-salvage surgery, with adjuvant radiotherapy when necessary, is an effective alternative to amputation in the majority of @entity1 with @entity242 of the forearm and hand. @entity137 is rarely a problem.

title: Limb salvage surgery and adjuvant radiotherapy for soft tissue XXXX of the forearm and hand.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Radiation toxicity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

answer: @entity242 :: (MESH:D012509,Disease) :: ['sarcomas']


abstract: Interleukin- (IL-) 2 is the major growth factor for T-cell activation and proliferation. @entity1199 has multiple functions in the regulation of immunological processes. Although most studies focus on T-cell immunomodulation, T-cell activation by @entity1199 is the foundation of priming the feedback loop. Here, we investigated the effect of MAPK/ @entity3963 and @entity10412 / @entity584 signaling pathways on @entity1199 -induced cell activation and the regulatory mechanisms of upstream ubiquitin ligase @entity2191 and @entity5315 . Morphological analysis of Jurkat T cells was performed by cytospin preparations with @entity32648 stain. @entity2902 expression on Jurkat T cells was determined by flow cytometry. Changes in cell activation proteins such as p- @entity3963 , @entity3963 , p- @entity584 , @entity584 , and ubiquitin ligase Casitas @entity1892 ( @entity5315 ) proteins were analyzed by western blot. Following @entity1199 -induced activation of Jurkat T cells, p- @entity3963 expression was upregulated, while there was no change in p- @entity584 , @entity3963 , or @entity584 expression. Thus, the MAPK/ @entity3963 signaling pathway, but not @entity10412 / @entity584 , was involved in @entity1199 -induced T-cell activation. Either using @entity4286 (a specific inhibitor for p- @entity3963 ) or depletion of @entity3963 with small interfering RNA (siRNA) reduced the expression of @entity2902 . This study also showed that ubiquitin ligase proteins @entity2191 and @entity5315 might be involved in @entity1199 -induced Jurkat T-cell activation by negatively regulating the MAPK/ @entity3963 signaling pathway.

title: The role of E3 ubiquitin ligase @entity5315 proteins in XXXX -induced Jurkat T-cell activation.

entities_list: @entity32648 :: ('MESH:C536749', 'Disease') :: ['Wright-Giemsa']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell Lymphoma']

answer: @entity1199 :: (3558,Gene) :: ['interleukin-2']


abstract: We compared the efficacy and side effects of @entity11622 (P), an injectable prodrug of @entity1443 , 2 g and @entity1340 (T), a weak synthetic opioid, 1.5 mg.kg-1, given intravenously following thyroidectomy. 80 @entity1 were randomly assigned to blindly receive one dose of P or T on request in the PACU. @entity158 was treated with i.v. PCA @entity1286 . @entity158 and @entity1 satisfaction were assessed with Visual Analog Scales. Demographic and peroperative data were comparable in both groups. Although the @entity1286 consumption was comparable (p = 0.71), the decrease in VAS @entity158 scores was significantly higher following @entity1340 (p = 0.03). More @entity1 complained of @entity390 and @entity391 (p = 0.01) during the first two hours following injection of @entity1340 , but there was no difference throughout the whole study. Oversedation was not observed in any group. We conclude that a single dose of @entity1340 provides a better quality of @entity1337 than @entity11622 during the first six hours after thyroidectomy, but fails to ensure optimal @entity1337 , since VAS @entity158 scores failed to fall below 3 despite the use of supplemental @entity1286 .

title: Intravenous @entity1340 compared to XXXX for postoperative @entity1337 following thyroidectomy.

entities_list: @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol']

entities_list: @entity11622 :: ('MESH:C063776', 'Chemical') :: ['propacetamol']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'Residual pain']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['acetaminophen']

answer: @entity11622 :: (MESH:C063776,Chemical) :: ['propacetamol']


abstract: BACKGROUND: Although resuscitative @entity432 of the aorta (REBOA) in various clinical settings was found to successfully elevate central blood pressure in @entity548 , this intervention is associated with high mortality and may represent a last-ditch option for @entity130 @entity1 . We conducted a retrospective study of @entity1 with @entity360 (UGIB) who underwent REBOA to identify the effectiveness of REBOA and reviewed published literatures. METHODS: REBOA were performed by trained acute care physicians in the emergency room and intensive care unit. The deployment of balloon catheters was positioned using ultrasonography guidance. Collected data included clinical characteristics, @entity548 severity, @entity1503 , metabolic values, blood transfusions, REBOA-related complications and mortality. A literature search using PUBMED to include " @entity432 " and " @entity360 " was conducted. RESULTS: REBOA was attempted in eight @entity1 among 140 @entity1 with UGIB and median age was 66  years. Systolic blood pressure significantly increased after REBOA (66        20 vs. 117        45  mmHg, p   <   0.01) and the total occlusion time of REBOA was 80        48  min. Strong positive correlations were found between total occlusion time of REBOA and @entity880 concentration (Spearman's r=0.77), clinical Rockwall score (Spearman's r=0.80), and age (Spearman's r=0.88), respectively. CONCLUSION: REBOA can be performed with a high degree of technical success and is effective at improving hemodynamic in @entity1 with UGIB. Correlations between total occlusion time and high @entity880 levels, clinical Rockall score, and age may be important for successful use of REBOA.

title: Resuscitative @entity432 of the aorta for uncontrollable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic', 'hemorrhagic shock']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood cultures']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['endovascular balloon occlusion', 'aortic occlusion']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding', 'nonvariceal upper gastrointestinal bleeding']

answer: @entity360 :: (MESH:D006471,Disease) :: ['nonvariceal upper gastrointestinal bleeding']


abstract: STUDY DESIGN: An evaluation of @entity3799 in @entity336 from newborn to adult life. OBJECTIVES: To discover the prevalence and natural history of @entity3799 in @entity336 . SUMMARY OF BACKGROUND DATA: Typical findings in this @entity1141 are sport-limbed @entity851 , @entity1159 , early @entity528 , and @entity85 such as @entity3799 , @entity1635 , and exaggerated @entity1515 . In @entity336 , spontaneous resolution of @entity3799 has been reported, but so have severe forms causing medullar compression leading to @entity1688 and @entity204 . The prevalence and clinical outcome of the @entity1513 are not known. METHODS: The radiographic natural history of the cervical spine was studied in 120 @entity1 . They varied in age from newborns to 63-year-olds. The average follow-up time in 26 living @entity1 with @entity3799 was 10.0 years. RESULTS: Midcervical @entity1513 was noted in 29 @entity1 (24%) in their first radiograph. In 25 @entity1 , the first radiographs were taken before the age of 18 months, and 24 of these @entity1 (96%) had @entity3799 . The most severe case was that of a 32-year-old @entity1 with a 165 degrees @entity1513 . In the 24 @entity1 , the @entity1513 resolved spontaneously at an average age of 7.1 years. Three @entity1 with a severe @entity1513 died; one @entity1 is alive. One @entity1 , a 4-year-old @entity1 has mild @entity85 . CONCLUSIONS: Cervical @entity1513 in @entity336 usually is shown at the time of birth. It resolves spontaneously during growth and seldom needs treatment. Careful follow-up study and treatment, if necessary, are important tools for avoiding the neurologic problems and fatal outcome.

title: Cervical @entity1513 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'patients', 'patient']

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriplegia']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['short stature']

entities_list: @entity336 :: ('MESH:C536170', 'Disease') :: ['diastrophic dysplasia']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1515 :: ('MESH:D008141', 'Disease') :: ['lumbar lordosis']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['cervical kyphosis']

entities_list: @entity1159 :: ('MESH:D003286', 'Disease') :: ['multiple joint contractures']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['spinal deformities', 'resolving deformity']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration of joints']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['rare skeletal dysplasia']

answer: @entity336 :: (MESH:C536170,Disease) :: ['diastrophic dysplasia']


abstract: RATIONALE: @entity13898 and epidermal growth factor (EGF), the ligands for @entity12841 ( @entity12841 ), stimulate fibroblast proliferation and play an important role in the pathogenesis of @entity3794 . Therefore, inhibition of the @entity12841 signal by an @entity12841 @entity669 kinase inhibitor ( @entity12841 -TKI) may prevent @entity3794 . However, there is a possibility that blocking the @entity12841 signal may inhibit epithelial cell repair, thereby exaggerating @entity82 . OBJECTIVE: To investigate the effect of @entity12841 -TK inhibition on @entity82 . METHODS: We looked at the effects of the @entity12841 -TKIs @entity4562 (20, 90, 200 mg/kg) and @entity20830 (12 mg/kg) on a @entity1732 -induced @entity82 model in @entity19 . MEASUREMENTS AND MAIN RESULTS: @entity4562 prevented @entity82 at all three doses. Furthermore, in those @entity19 that did not receive @entity1732 treatment, @entity4562 at 200 mg/kg did not induce @entity82 . Immunohistochemistry revealed that phosphorylation of @entity12841 in lung mesenchymal cells induced by @entity1732 was inhibited by @entity4562 . @entity20830 also attenuated the @entity82 . In vitro studies further demonstrated that the addition of @entity4562 or @entity20830 suppressed the @entity12841 ligand-induced proliferation of lung fibroblasts. CONCLUSIONS: These findings suggest that, in the preclinical setting, @entity12841 -TKIs may have a protective effect on @entity82 induced by @entity1732 . Because these molecular targeted drugs may have differing effects depending on species and individuals, a cautious interpretation is warranted.

title: @entity4562 prevents @entity1732 -induced XXXX in @entity19 .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['lung fibrosis']

entities_list: @entity13898 :: ('21802(Tax:10090)', 'Gene') :: ['Transforming growth factor-alpha']

entities_list: @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib', 'Gefitinib']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity82 :: (MESH:D005355,Disease) :: ['lung fibrosis']


abstract: OBJECTIVE: In 1970, Guze and Robins published a meta-analysis of suicide in @entity1 with affective illness that inferred a lifetime risk of 15%. Since then, this figure has been generalized to all @entity308 and cited uncritically in many papers and textbooks. The authors argue for an alternative estimate of suicide risk and question the generalizability of the Guze and Robins estimate. METHOD: The authors sorted studies obtained through a literature search that included data pertaining to suicide occurrence in affective illness into one of three groups: outpatients, inpatients, or suicidal inpatients. Suicide risks were calculated meta-analytically for these three groups, as well as for two previously published collections. RESULTS: There was a hierarchy in suicide risk among @entity1 with @entity1316 . The estimate of the lifetime prevalence of suicide in those ever hospitalized for suicidality was 8.6%. For @entity1316 @entity1 hospitalized without specification of suicidality, the lifetime risk of suicide was 4.0%. The lifetime suicide prevalence for mixed inpatient/outpatient populations was 2.2%, and for the nonaffectively ill population, it was less than 0.5%. CONCLUSIONS: The percentage of subjects dead due to suicide (case fatality prevalence) is a more appropriate estimate of suicide risk than the percentage of the dead who died by suicide (proportionate mortality prevalence). More important, it is well established that @entity1 with @entity1316 suffer a higher risk of suicide relative to the general population. However, no risk factor, including classification of diagnostic subtype, has been reliably shown to predict suicide. This article demonstrates a hierarchy of risk based on the intensity of the treatment setting. Given that @entity1 with a hospitalization history, particularly when suicidal, have a much elevated suicide prevalence over both @entity146 outpatients and nonpatients, the clinical decision to hospitalize in and of itself appears to be a useful indicator of increased suicide risk.

title: XXXX and suicide risk: a reexamination.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorders', 'affective disorder']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity1316 :: (MESH:D019964,Disease) :: ['Affective disorders']


abstract: Arterial relaxant responses to beta adrenoceptor agonists are decreased in spontaneously @entity101 @entity35 (SHR) when compared with normotensive @entity35 -Kyoto @entity35 (WKY). To determine which component of the beta adrenoceptor-adenylate cyclase (AC) system is involved in the decreased beta adrenoceptor responses, effects of two activators of AC- @entity1928 and cholera toxin and of @entity5393 ( @entity5393 ) were compared between the strips of femoral arteries isolated from 13-week-old SHR and age-matched WKY. Arterial relaxant responses to either @entity1928 , an activator of AC or @entity5393 were not significantly different between the SHR and WKY, whereas the relaxant responses to @entity1063 (NE) via beta adrenoceptors were significantly weaker in the SHR than in the WKY. In the absence of @entity6839 , @entity5543 adrenoceptor antagonist, contractile responses to NE were significantly greater in the SHR than in the WKY. @entity6839 augmented the contractile responses to NE to a greater extent in the WKY than in the SHR. After the blockade by @entity6839 of beta adrenoceptors, contractile responses to alpha adrenoceptor stimulation with NE were not significantly different between the two strains. The pretreatment of the strips with cholera toxin, an activator of stimulatory GTP-binding protein (Gs), antagonized the alpha adrenoceptor-mediated contractions much greater in the WKY than in the SHR. The alpha adrenoceptor-mediated contractions after the pretreatment with cholera toxin were comparable to the contractile responses to NE determined in the absence of @entity6839 in either the SHR or the WKY. @entity1928 and @entity5393 also antagonized the alpha adrenoceptor-mediated contractions. However, these antagonisms were not significantly different between the two strains. The cellular @entity268 content in arterial strips after the stimulation with NE was significantly less in the SHR than in the WKY, whereas the @entity268 contents were similar in arterial strips from both strains which were stimulated with @entity1928 . These results suggest that the reduced function of Gs is involved in the abnormality of beta adrenoceptor-AC system in the SHR femoral artery.

title: Reduced function of the stimulatory GTP-binding protein in beta adrenoceptor-adenylate cyclase system of femoral arteries isolated from spontaneously @entity101 XXXX .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity6839 :: ('MESH:D013999', 'Chemical') :: ['timolol', 'Timolol']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin', 'Forskolin']

entities_list: @entity5393 :: ('MESH:D003994', 'Chemical') :: ['DBcAMP', 'dibutyryl cyclic AMP']

answer: @entity35 :: (10116,Species) :: ['rats']