abstract: @entity1853 adenosyltransferase (MAT) catalyzes the biosynthesis of @entity7726 ( @entity7726 ), a key molecule in transmethylation reactions and polyamine biosynthesis. The @entity26985 isozyme consists of a catalytic alpha2 and a regulatory beta subunit. Down-regulation of the @entity26985 subunit expression causes a 6-10-fold increase in intracellular @entity7726 levels. To understand the mechanism by which the beta subunit expression is regulated, we cloned the @entity26985 gene, determined its organization, characterized its 5'-flanking sequences, and elucidated the in vitro and in vivo regulation of its promoter. Transcription of the @entity26985 gene initiates at position -203 relative to the translation start site. Promoter deletion analysis defined a minimal promoter between positions +52 and +93 base pairs, a GC-rich region. Inclusion of the sequences between -4 and +52 enhanced promoter activity; this was primarily because of an @entity3419 recognition site at +9/+15. The inclusion of sequences up to position -115 provided full activity; this was attributed to a TATA at -32. The @entity3419 site at position +9 was key for the formation of protein.DNA complexes. Mutation of both the @entity3419 site at +9 and the TATA at -32 reduced promoter activity to its minimal level. Supershift assays showed no effect of the anti- @entity3419 antibody on complex formation, whereas the anti- @entity28549 antibody had a strong effect on protein.DNA complex formation, suggesting that @entity28549 is one of the main factors binding to this @entity3419 site. Chromatin immunoprecipitation assays supported the involvement of both @entity3419 and @entity28549 in complexes formed on the @entity26985 promoter. The data show that the 5'-untranslated sequences play an important role in regulating the @entity26985 gene and identifies the @entity3419 site at +9 as a potential target for modulating @entity26985 expression, a process that can have a major effect on intracellular @entity7726 levels.

title: Regulation of the human @entity26985 gene encoding the regulatory beta subunit of @entity1853 adenosyltransferase, XXXX .

entities_list: @entity1853 :: ('MESH:D008715', 'Chemical') :: ['Methionine']

entities_list: @entity7726 :: ('MESH:D012436', 'Chemical') :: ['S-adenosylmethionine', 'AdoMet']

answer: @entity26985 :: (27430,Gene) :: ['MAT II']


abstract: BACKGROUND: The aim of this study was to determine the rate of health care-associated @entity281 (HC-AI) and device-associated health care-associated @entity281 (DA-HAIs), and distribution of causative microorganisms and etiologic factors responsible for these @entity281 in a neonatal intensive care unit (NICU) of a state hospital in southeastern @entity233 . METHODS: A laboratory-based, active, prospective @entity580 surveillance study was performed in NICUs from January 2008 to December 2011. The rates of HC-AIs were determined on a daily basis. The findings were evaluated by applying the definitions of the Centers for Disease Control and Prevention National Healthcare Safety Network. RESULTS: In a 4-year period, 580 HC-AIs, 81 of which were DA-HAIs, were detected among 6932 @entity1 . The rate of hospital acquired @entity281 was 8.3% and 7.69/1000 @entity1 days. @entity2489 ( @entity2489 ) was the second most frequent (13.1%) HC-AI and the most frequent was DA-HAI. The @entity2489 rate was 6.4 per 1000 ventilator days. Mechanical ventilation was the most frequently used invasive device. Median time to diagnosis of @entity2489 was 32.11    29.3 days from the time of admission. @entity3064 (48%) and @entity796 (32%) were the most frequent microorganisms. @entity3273 was the most effective antibiotic by in vitro test. The antibiotic resistance ratios of A. baumannii were >=54% for carbapenems, @entity581 , and @entity2891 - @entity5899 ; >=88% for @entity5176 ; and >=92% for @entity5505 , @entity2756 , and @entity3400 - @entity7120 . CONCLUSIONS: Device-associated @entity580 was a particularly important problem in NICU. Close monitoring will decrease the rates of device-related @entity580 .

title: A 4-year surveillance of device-associated XXXX in a neonatal intensive care unit.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity3273 :: ('MESH:D003091', 'Chemical') :: ['Colistin']

entities_list: @entity5899 :: ('MESH:D013407', 'Chemical') :: ['sulbactam']

entities_list: @entity5176 :: ('MESH:D015363', 'Chemical') :: ['quinolones']

entities_list: @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity2489 :: ('MESH:D053717', 'Disease') :: ['Ventilator-associated pneumonia', 'VAP']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infection', 'nosocomial infections']

entities_list: @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin']

entities_list: @entity2891 :: ('MESH:D002438', 'Chemical') :: ['cefoperazone']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']

entities_list: @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime']

answer: @entity580 :: (MESH:D003428,Disease) :: ['nosocomial infections']


abstract: Disorders involving regulation of affect commonly occur in @entity15 ( @entity15 ). These include various clinical presentations with inconsistent definitions that lead to many nomenclatures. In order to simplify the clinical approach to dysregulation of affect (DyA) a phenomenological definition was applied that unifies and combines the current classifications. Accordingly, the prevalence of DyA was determined in @entity15 @entity1 and comorbidity was evaluated with @entity146 . Using the @entity922 ( @entity922 ), 651 consecutive @entity15 @entity1 were assessed (474 female, 177 male, mean age 43.6 years, mean disease duration 11.5 years) and it was found that the prevalence of DyA was 6.5% (n = 42). In 14 @entity1 (33.3% of DyA @entity1 ) there was no associated @entity146 comorbidity, while in 28 @entity1 (66.6%) there was comorbid psychopathology; 12 had been suffering from @entity716 (28.6%), eight from @entity1316 (19%), six from @entity73 (14.3%) and two from @entity1314 (4.7%). In 15 @entity1 (35.7%) the DyA was ego- @entity3520 and in 27 @entity1 (64.3%) the symptoms of DyA were ego-syntonic. All @entity1 with comorbid @entity716 had ego-syntonic DyA. In 14.3% of @entity1 the DyA symptomatology preceded the appearance of @entity15 . It is concluded that the new phenomenological definition of DyA aids in distinguishing this symptom from other psychopathologies and can serve as a tool for neurologists in defining this unique entity.

title: Dysregulation of affect in XXXX : new phenomenological approach.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality disorder']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['Structured Clinical Interview for DSM-III-R', 'SCID']

answer: @entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']


abstract: OBJECTIVES: To determine the diagnoses of US military @entity1 medically evacuated from Central and Southwest Asia for ill-defined @entity66 , to compare these diagnoses with data from earlier military conflicts, and to identify ways to reduce the number of dermatologic evacuations of military personnel from the combat zone. DESIGN: We evaluated the preevacuation and postevacuation diagnoses of military personnel who were evacuated from Central and Southwest Asia for ill-defined dermatologic conditions. Outside the combat zone, these individuals were examined by dermatologists who provided a diagnosis regarded as correct for the purposes of this study. We excluded @entity1 with precise preevacuation diagnoses, battle-related @entity130 , and incomplete identifying data. SETTING: The geographic area of responsibility for the US Central Command, including Iraq and Afghanistan. Data from January 1, 2003, through December 31, 2006, were obtained from aeromedical evacuation records and the military's electronic medical records system. @entity1 : A total of 170 @entity1 evacuated from the combat zone for ill-defined @entity66 , such as @entity272 , not otherwise specified (International Classification of Diseases, Ninth Revision, Clinical Modification code 709.9). MAIN OUTCOME MEASURES: The postevacuation diagnosis assigned, in nearly all cases, by a board-certified dermatologist. RESULTS: @entity1909 , @entity8205 , @entity5 , benign @entity5 , @entity110 , and a group of nonspecific diagnoses were the most common postevacuation diagnoses. CONCLUSIONS: We propose that thorough predeployment identification of individuals with chronic @entity272 , emphasis of preventive measures, and development of treatment plans will reduce the number of dermatologic evacuations. Improving diagnostic accuracy and treatment plans via teledermatology may also reduce evacuations. The most common @entity66 leading to evacuations are similar to those from 20th century wars.

title: Military aeromedical evacuations from central and southwest Asia for ill-defined XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['dermatologic diseases']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant neoplasms', 'neoplasms']

entities_list: @entity8205 :: ('MESH:D009508', 'Disease') :: ['benign melanocytic nevus']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorder', 'skin diseases']

entities_list: @entity110 :: ('MESH:D014581', 'Disease') :: ['urticaria']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['Dermatitis']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['cutaneous injuries']

answer: @entity66 :: (MESH:D004194,Disease) :: ['dermatologic diseases']


abstract: From the population covered by the @entity5 Registry (northern Italy), all 2,259 @entity2 @entity1 diagnosed from 1976 to 1981 were followed through 30 November 1989. The length of follow-up ranged from eight to 13 years. A special investigation on long-term survivors showed that a negligible proportion (0.01 percent) of errors occur in determining life status when an active follow-up is adopted. Age, stage, and histotype were found to be statistically significant, independent, prognostic factors in multivariate analysis both by the Cox model and by a model considering the relative survival. Observed survival was 29 percent at one year after diagnosis, 13 percent at two years, eight percent at three years, five percent at five years and two percent at 10 years. Survival decreased with age, but the youngest @entity1 of both sexes showed lower survival compared with immediately subsequent ages. Among morphologically confirmed @entity5 , @entity957 and @entity420 showed the highest survival (38 percent and 33 percent at one year, respectively); @entity4153 showed the poorest prognosis (one-year survival, 23 percent). Beyond the second year after diagnosis, differences between histotypes became slighter. Survival according to stage showed a decreasing pattern from limited to advanced @entity5 , one-year figures being 41 percent for localized @entity5 , 27 percent for regional @entity3 , and three percent for distant @entity3 . Relative survival in Varese was compared with that reported by other @entity5 registries in Western countries: the variability noted could be related to different modalities of registration and to different distribution of clinical and demographic factors.

title: Survival for XXXX in northern Italy.

entities_list: @entity4153 :: ('MESH:D018288', 'Disease') :: ['small cell carcinomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Lombardy Cancer', 'cancer', 'tumors']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['epidermoid carcinomas']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: OBJECTIVE: Among indirect measures of @entity10478 , A Body Shape Index (ABSI), which is defined as waist circumference (WC)/(body mass index (BMI)(2/3)*height(1/2)), is unique in that ABSI is positively correlated with @entity10478 and is supposed to be independent of BMI. ABSI has been also shown to be linearly and positively associated with visceral fat mass and all-cause and @entity65 ( @entity65 ) in the general population. It is, however, uncertain whether ABSI could be associated with @entity432 in @entity1 with @entity6 . METHODS: This is a cross-sectional study of 607 @entity1 with @entity164 2 @entity6 (mean age 64  12   years; 40.0% female). Visceral fat area (VFA, cm(2)) and subcutaneous fat area (SFA, cm(2)) were assessed with a dual-impedance analyzer. In order to estimate the risk for @entity65 , brachial-ankle pulse wave velocity (baPWV, cm) was used for the assessment of @entity432 . RESULTS: ABSI was significantly and positively correlated with VFA (r=0.138, p=0.001) and negatively associated with BMI (r=-0.085, p=0.037). The correlation of z-score for ABSI with VFA remained significant (r=0.170, p<0.001) but not with BMI (r=0.009, p=0.820). ABSI (standardized b 0.095, p=0.043) but not WC (standardized b -0.060, p=0.200) was significantly and positively correlated with baPWV in the multivariate model including BMI as a covariate. CONCLUSIONS: ABSI appears to reflect @entity10478 independently of BMI and to be a substantial marker of arterial stiffening in @entity1 with @entity164 2 @entity6 .

title: Indirect measure of XXXX 'A Body Shape Index' (ABSI) is associated with @entity432 in @entity1 with @entity164 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity10478 :: ('OMIM:155310', 'Disease') :: ['visceral adiposity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial stiffness']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity10478 :: (OMIM:155310,Disease) :: ['visceral adiposity']


abstract: Eight @entity1 with disseminated @entity281 following injection of BCG into primary @entity320 have been studied. These @entity1 developed persistent fevers beginning 9 to 20 days following BCG injection. Severe @entity409 occurred in all @entity1 and peaked approximately 20 days following BCG injection. The persistent fevers, and clinical signs and symptoms of disseminated @entity281 lasted from 7 to 22 days before subsiding. @entity409 sometimes took six months to return to normal. Evidence of @entity738 in liver and bone marrow were present. The natural course of this disease did not appear to be affected by therapy with @entity3109 (INH). In vitro immunologic studies revealed a severe @entity308 of lymphocyte reactivity in five of six @entity1 sequentially tested. Wide dissemination of BCG from the site of injection is a severe complication of BCG therapy. The clinical course of this disease and suggestions for management are described in this paper.

title: Clinical and immunologic studies of disseminated XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver function abnormalities', 'Liver function abnormalities']

entities_list: @entity3109 :: ('MESH:D007538', 'Chemical') :: ['isoniazid']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['BCG infection']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanomas']

answer: @entity281 :: (MESH:D007239,Disease) :: ['BCG infection']


abstract: This study investigated the possible ameliorative effects of adipose-derived stem cells-conditioned medium (ASC-CM) on experimental @entity385 . In vivo @entity385 was induced in @entity19 after 2h of @entity2500 ( @entity2500 ) followed by 22 h reperfusion. Culture of SH-SY5Y @entity1 @entity521 cells with 100  M @entity2227 for 24h was used as an in vitro neuronal apoptosis model. Intracerebroventricular (i.c.v.) administration of 30- and 100-fold concentrated @entity19 ASC-CM 1h prior to @entity2500 resulted in a dose-dependent reduction in the @entity1188 volume and the @entity4 . The administration of @entity19 ASC-CM immediately after @entity2500 was also effective, but administration 2h after @entity2500 was not. Neuroprotective effects of @entity19 ASC-CM were also confirmed in an in vitro model. Pretreatment with 100-fold concentrated @entity19 ASC-CM at 10% of the total culture volume significantly reduced @entity2227 -induced excitotoxicity in the SH-SY5Y cells. Similar reduction in the @entity2500 -induced @entity1188 volume was seen following i.c.v. administration of 100-fold concentrated @entity1 ASC-CM or @entity19 ASC-CM. In conclusion, ASC-CM appears to exert ameliorative effects on experimental @entity385 i\n both in vivo and in vitro models. These findings suggest the feasibility of ASC-CM administration as a therapy for acute stage @entity64 .

title: The conditioned medium of @entity19 and @entity1 adipose-derived stem cells exerts neuroprotective effects against experimental XXXX model.

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['brain swelling']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVE: To assess the hypothesis that @entity3509 ( @entity3509 ) is a problem often not optimally treated. Long delays in diagnosis are common, long hospital stays are typical and recovery with surgery is relatively rapid. DESIGN: A chart review. SETTING: The Regina Health District associated hospitals, a tertiary referral centre. @entity1 : The charts of 34 consecutive @entity1 having primary @entity11127 and seen during the 6-year period Apr. 1, 1991, to Mar. 31, 1997, were identified. OUTCOME MEASURES: @entity1 presentation, time until diagnosis of @entity3509 , number of radiologic investigations, microbiologic features, treatment methods, postoperative course and mortality. RESULTS: The mean delay in diagnosis, defined as the time of admission to the time of correct diagnosis, was 44.2 days (range from 0 to 573 days) and the mean delay until thoracic surgery referral was 47.4 days (range from 0 to 578 days). On average each @entity1 underwent CT 10.1 times, had 2.6 percutaneous drainage procedures and 2.0 chest tube insertions. The mean time from the first percutaneous chest drainage to the date of diagnosis was 29.8 days (range from 0 to 564 days). Of the 26 @entity1 who underwent CT, the mean time from the first CT of the chest to the date of diagnosis was 9.5 days (range from 0 to 75 days). Cultures of pleural fluid grew no organisms in 17 @entity1 ; in the remaining 17 @entity1 cultures grew 23 different microorganisms. Of 26 @entity1 who were referred for surgical opinion, 18 underwent decortication; 8 were not considered to be surgical candidates. Pathological examination showed 17 cases of inflammatory @entity3509 and 1 case of @entity2615 (unrecognized clinically). The mean length of hospital stay postoperatively was 15.2 days. CONCLUSIONS: Early suspicion of @entity3509 facilitates its treatment, resulting in fewer investigations and shorter hospital stays. When percutaneous drainage does not eliminate @entity1143 , @entity3509 must be considered. Recovery from surgical decortication is rapid in comparison with the typical protracted preoperative hospital course.

title: XXXX : lack of awareness results in a prolonged clinical course.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'Patient']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions']

entities_list: @entity11127 :: ('MESH:D012140', 'Disease') :: ['respiratory tract disease']

entities_list: @entity3509 :: ('MESH:D004653', 'Disease') :: ['ET', 'empyema thoracis', 'empyema']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma']

answer: @entity3509 :: (MESH:D004653,Disease) :: ['Empyema thoracis']


abstract: BACKGROUND: A @entity85 may be associated with @entity18348 ( @entity18348 ), and has, until recently, been thought to be resistant to nonoperative management. The purpose of this report was to describe the use of the Ponseti method in the treatment of 5 @entity1 whose clubfeet were associated with this syndrome. METHODS: All @entity1 with a diagnosis of clubfoot, who were treated at the Orthopaedic Hospital Clubfoot Clinic, over a period of 4 years, were reviewed. During that period, a total of 131 @entity1 with 194 clubfeet were treated. We identified 5 @entity1 (3.8%) with 6 clubfeet associated with @entity18348 . The @entity1 were managed using the Ponseti method. One of the @entity1 , with a contralateral amputation of the limb opposite to the side with a clubfoot, required the use of a unilateral foot abduction orthosis rather than a conventional foot abduction orthosis. The outcomes evaluated included: the number of casts needed to obtain correction, the percentage of @entity1 requiring a tendo-Achilles tenotomy, the number of relapses, and the need for additional secondary procedures. RESULTS: The mean age at presentation for the 5 @entity1 was 6.2 weeks. Four of the clubfeet had an ipsilateral band and 2 did not. None of the @entity1 had a @entity51 distal to a band. The mean number of casts used to correct the deformity was 6, and a percutaneous tendo-Achilles tenotomy was done in all cases. All of the feet achieved initial correction. Four @entity1 (5 feet) experienced a relapse attributed to failure to use the postcorrective brace as prescribed. Correction of the foot in 3 of these @entity1 was regained and maintained by another series of manipulation and cast application followed by resumption of bracing. One @entity1 underwent an anterior tibial tendon transfer. The @entity1 were followed for an average of 32.6 months (21 to 49 mo). All feet were supple and plantigrade at latest follow-up evaluation. CONCLUSIONS: The Ponseti method may be successfully applied to clubfeet associated with @entity18348 . LEVEL OF EVIDENCE: Level IV.

title: The use of the Ponseti method to treat clubfeet associated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'infants']

entities_list: @entity18348 :: ('MESH:C531614', 'Disease') :: ['congenital annular band syndrome', 'CABS']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['clubfoot deformity']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

answer: @entity18348 :: (MESH:C531614,Disease) :: ['congenital annular band syndrome']


abstract: STUDY OBJECTIVE: Ureteral @entity46 is rare, accounting for less than 0.3% of all endometriotic lesions. The aim of our study is to evaluate the prevalence of extrinsic @entity1901 in @entity1 undergoing laparoscopic surgery for severe @entity46 and to suggest that laparoscopic ureterolysis represents a mandatory measure in all cases to avoid @entity1901 . METHODS: A retrospective analysis was performed of all cases of @entity1 who underwent laparoscopic surgery for severe @entity46 at the departments of obstetrics and gynecology at CMCO-SIHCUS and Hautepierre Hospital, Strasbourg, from November 2004 through January 2006. MEASUREMENTS AND MAIN RESULTS: We recorded 54 @entity1 with a mean age of 31 years and a mean body mass index of 21.9. @entity1109 were @entity1834 (88%), severe @entity546 (88%), severe @entity2371 (38.8%), and @entity249 (74%). Five @entity1 presented with @entity3833 , frequency, recurrent @entity293 , and @entity158 in the renal angle, and 2 @entity1 had @entity3041 . We observed 3 @entity1 (5.6%) with @entity1901 , 35 (64.8%) with adenomyotic tissue surrounding the ureter without @entity850 , and 16 (29.6%) with adenomyotic tissue adjacent to the ureter. It was on the left side in 47.4% of cases, on the right side in 31.6% cases, and bilaterally in 21% of cases. In 9 @entity1 , ureteral involvement was associated with @entity1494 (16.7%). In all @entity1 , ureterolysis was performed. There was 1 case of @entity1901 during the procedure, 2 of transitory urinary retention, and 1 of @entity12478 after surgery. During the first year of follow-up, the disease recurred in 4 @entity1 , with no evidence of the disease in the urinary tract. CONCLUSION: Conservative laparoscopic surgery to relieve @entity1695 and remove pathologic tissue is the management of choice. Resection of part of the ureter should be performed only in exceptional cases. Ureterolysis should be performed in all @entity1 before endometriotic nodule resection to recognize and prevent any @entity16 .

title: Laparoscopic management of XXXX : our experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity1901 :: ('MESH:D014515', 'Disease') :: ['ureteral endometriosis', 'ureteral injury', 'ureteral stenosis']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder endometriosis']

entities_list: @entity12478 :: ('MESH:D014624', 'Disease') :: ['uretero-vaginal fistula']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['ureteral obstruction']

entities_list: @entity1834 :: ('MESH:D004412', 'Disease') :: ['dysmenorrhea']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['Reported symptoms']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['ureteral damage']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections']

answer: @entity1901 :: (MESH:D014515,Disease) :: ['ureteral endometriosis']


abstract: STUDY OBJECTIVE: To estimate whether the suture of the ovary is superior to @entity162 in preserving ovarian reserve in infertile @entity1 undergoing laparoscopic stripping of @entity46 . DESIGN: Randomized controlled trial (Canadian Task Force classification I). SETTING: University teaching hospital. @entity1 : 100 @entity1 with @entity46 . INTERVENTIONS: @entity1 underwent stripping of @entity46 and were randomized to undergo hemostasis by use of either laparoscopic suturing (LS group) or @entity162 (BC group). Changes in ovarian reserve were investigated by measuring the levels of anti-Mullerian hormone ( @entity248 ) and basal follicle-stimulating hormone (FSH) before surgery and at 3, 6 and 12 months from surgery. MEASUREMENTS AND MAIN RESULTS: At 3-month, 6-month, and 12-month follow-up, in both study groups, postsurgical @entity248 levels were significantly lower and basal FSH levels were significantly higher than before surgery. There was no significant difference in the mean percentage decrease of @entity248 levels in the BC group and LS group at 3-, 6-, and 12-month follow-up. The mean percentage increase in basal FSH was higher in the BC group than in the LS group at both 3-month (p = .023) and 6-month follow-up (p = .029), but not at 12-month follow-up. Pregnancy rate, time to conception, and rate of @entity46 recurrence was similar in the 2 study groups. CONCLUSION: Laparoscopic stripping of ovarian endometriotic cyst significantly decreases serum @entity248 levels and increases basal FSH levels independent from the method used to obtain hemostasis on the ovarian tissue.

title: Hemostasis by XXXX versus suture after surgical stripping of bilateral ovarian endometriomas: a randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar coagulation']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometrioma', 'bilateral endometriomas']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar coagulation']


abstract: Macrophages in the injured spinal cord originate from resident microglia and blood monocytes. Whether this diversity in origins contributes to their seemingly dual role in immunopathology and repair processes has remained poorly understood. Here we took advantage of @entity35028 @entity19 to visualise monocyte-derived macrophages in the injured spinal cord via adoptive cell transfer and bone marrow (BM) chimera approaches. We show that the majority of infiltrating monocytes at 7 days post-injury originate from the spleen and only to a lesser extent from the BM. Prevention of early monocyte infiltration via splenectomy was associated with improved recovery at 42 days post-SCI. In addition, an increased early presence of infiltrating monocytes/macrophages, as a result of CX   @entity20305 deficiency within the peripheral immune compartment, correlated with @entity130 outcomes. Adoptive transfer of identified Cx   @entity20305 ( @entity35028 /+) monocytes confirmed peak infiltration at 7 days post-injury, with inflammatory ( @entity19347 (high)) monocytes being most efficiently recruited. Focal SCI also changed the composition of the two major monocyte subsets in the blood, with more @entity19347 (high) cells present during peak recruitment. Adoptive transfer experiments further suggested high turnover of inflammatory monocytes in the spinal cord at 7 days post-injury. Consistent with this, only a small proportion of infiltrating cells unequivocally expressed polarisation markers for pro-inflammatory (M1) or alternatively activated (M2) macrophages at this time point. Our findings offer new insights into the origins of monocyte-derived macrophages after SCI and their contribution to functional recovery, providing a basis for further scrutiny and selective targeting of @entity19347 (high) monocytes to improve outcomes from neurotraumatic events.

title: Mobilisation of the splenic monocyte reservoir and peripheral CX   XXXX deficiency adversely affects recovery from spinal cord injury.

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['worsened injury']

answer: @entity20305 :: (12902(Tax:10090),Gene) :: ['CR1']


abstract: BACKGROUND: The purpose of the present study was to evaluate the clinicopathologic factors and ultrasound (US) features predictive of central lymph node @entity3 (LNM) in @entity1 diagnosed with @entity7172 ( @entity7172 ). METHODS: From March 2008 to August 2008, the clinicopathologic features and preoperative US features of 483 @entity1 who were diagnosed with conventional @entity7172 were included. Medical records, US features, and pathology reports of all @entity1 were retrospectively reviewed. Univariate and multivariate analysis was performed to identify clinicopathological prognostic factors associated with central LNM. Odds ratios (OR) with relative 95 % confidence intervals (95 % CI) were calculated to determine the relevance of all potential predictors of central LNM. RESULTS: Among the 483 @entity1 with @entity7172 , 139 (28.8 %) @entity1 had central LNM. The OR of significant independent factors were 2.055 (95 % CI, 1.137-3.716), 2.075 (95 % CI, 1.27-3.39), 1.71 (95 % CI, 1.073-2.724), and 15.897 (95 % CI, 4.173-60.569), respectively, for bilaterality, larger @entity5 size (>5 mm), extracapsular invasion, and lateral LNM. No significant association was seen among the US features of @entity7172 with central LNM. CONCLUSIONS: Central lymph node @entity3 in @entity1 with @entity7172 was significantly associated with various clinicopathological factors, including larger @entity5 size (>5 mm), bilaterality, extracapsular invasion, and lateral LNM. When these features are detected on preoperative US, selective central compartment dissection may be helpful in @entity1 diagnosed with @entity7172 .

title: Preoperative prediction of central lymph node XXXX in thyroid @entity7172 using clinicopathologic and sonographic features.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity7172 :: ('MESH:C563277', 'Disease') :: ['PTMC', 'papillary thyroid microcarcinoma']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: AIM: To analyze retrospectively the surgical management of @entity146 (AAD), @entity3473 ( @entity3473 ) and @entity1645 ( @entity1645 ) with @entity1644 through a single-stage posterior approach. MATERIAL AND METHODS: Forty-three @entity1 with reducible AAD, @entity3473 and @entity1645 with @entity1644 underwent surgery from January 2009 to January 2013. Intraoperative restoration followed by posterior decompression and plate-rod placement with occipital cortical screws and C2/C3 lateral mass cortical screws fixation devices were used in all @entity1 . Results were recorded both pre- and postoperatively and these outcome measures included Nurick grading (NG) and radiology findings (atlantodental interval (ADI), space available for the spinal cord (SAC), interval between odontoid and Chamberlain's line (IOC), and the cervicomedullary angle (CMA)). RESULTS: Forty (93%) of the 43 @entity1 were followed up. Thirty-six (90%) @entity1 ' symptoms improved and four (10%) stabilized. No @entity1 became progressively worse. The difference between preoperative and postoperative Nurick grades was statistically significant. All @entity1 achieved restoration, including thirty (75%) @entity1 had full restoration and ten (25%) had part restoration. The size of @entity1644 was obviously decreased in 32 (80%) @entity1 and stable in 8 (20%) @entity1 . All radiology findings (ADI, IOC, SAC, CMA) showed significant changes from pre- to postoperative (p < 0.01). CONCLUSION: Intraoperative distraction, extension combined posterior decompression with use of plate-rod-screws occipitocervical fusion device is an effective method to treat AAD, @entity3473 and @entity1645 with @entity1644 .

title: Surgical Management of Adult Reducible Atlantoaxial Dislocation, @entity3473 and @entity1645 with XXXX .

entities_list: @entity1644 :: ('MESH:D013595', 'Disease') :: ['syringomyelia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['reducible atlantoaxial dislocation']

entities_list: @entity1645 :: ('MESH:D001139', 'Disease') :: ['Chiari malformation', 'CHM']

entities_list: @entity3473 :: ('MESH:D007443', 'Disease') :: ['BI', 'basilar invagination']

answer: @entity1644 :: (MESH:D013595,Disease) :: ['Syringomyelia']


abstract: OBJECTIVES: @entity1 with @entity449 have significant comorbidities which influence outcome. Our practice includes comprehensive assessment to identify comorbidities, allowing subsequent medical optimisation prior to @entity439 repair. The aim of this study was to assess this process and to identify any factors predictive of outcome. DESIGN: Prospective observational study. MATERIALS: Medical case notes of 200 @entity1 referred with aortic pathology. METHODS: Data analysed included preoperative, perioperative and postoperative factors. Multiple logistic regression analysis was performed to identify predictors of outcome. RESULTS: Following assessment 17 @entity1 (8.5%) were found to be unfit for intervention and 165 @entity1 (82.5%) proceeded to @entity439 repair. In this group assessment uncovered previously undiagnosed @entity712 in 19%, 57% and 29% of @entity1 respectively. Multiple logistic regression analysis indicated that optimisation by a renal physician reduced post-operative @entity8 (OR 0.12, 95% CI 0.03-0.45, P=0.002) while optimisation by a @entity1576 (OR 0.7, 95% CI 0.05-0.99, P=0.049). An abnormal echocardiogram was associated with @entity55 (OR 6.9, 95% CI 1.6-29, P=0.01) and @entity204 (OR 7.9, 95% CI 1.15-54, P=0.036). CONCLUSION: Pre-operative assessment identifies previously undiagnosed comorbidity in a significant proportion of @entity1 . Subsequent medical optimisation may reduce post-operative morbidity and mortality.

title: Medical optimisation can reduce morbidity and mortality associated with elective XXXX repair.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac, respiratory and renal comorbidity']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysms']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['cardiologist reduced respiratory complications']

answer: @entity449 :: (MESH:D001014,Disease) :: ['aortic aneurysm']


abstract: Using functional magnetic resonance imaging (fMRI) we were able to observe, in detail, ictal brain hemodynamics during @entity302 caused by a @entity1313 . A 53-year-old @entity1 was experencing partial motor @entity410 of the left side of his face and neck. In a brain MR image a @entity66 was found in the subcortical area of the right frontal lobe. We found focal spikes in his right hemisphere, though dominantly in C4 and T4 regions. fMRI investigations were carried out at 1.5 T (GE Signa Horizon) using gradient-echo echo-planar neuroimaging. We were able to perform the ictal examination twice. The activated regions were focalized and clearly found only on the lateral side of the @entity5 base. The region was in agreement with the @entity302 focus examined using an electrocorticogram (ECOG). The signal intensity in the @entity410 focus rapidly increased 30 seconds before the @entity410 was observed. After the end of the @entity410 it also took 30 seconds to restore the signal intensity to the baseline value. fMRI is a very useful tool for various studies such as the identification of the @entity302 focus, the mechanism of @entity302 , and so on.

title: Ictal brain hemodynamics in the XXXX focus caused by a @entity1313 using functional magnetic resonance imaging (fMRI).

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'convulsion']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['mass lesion']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epileptic seizure']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic']


abstract: @entity463 ( @entity463 ) is associated with infiltration of peritumoral (PT) parenchyma by @entity5 cells that leads to @entity5 regrowth. Recently, @entity463 stem-like or initiating cells (GICs) have been identified in the PT area, but whether these GICs have enhanced migratory and invasive capabilities compared with GICs from the @entity5 mass (TM) is presently unknown. We isolated GICs from the infiltrated PT tissue and the TM of three @entity1 and found that PT cells have an advantage over TM cells in two-dimensional and three-dimensional migration and invasion assays. Interestingly, PT cells display a high plasticity in protrusion formation and cell shape and their migration is insensitive to substrate stiffness, which represent advantages to infiltrate microenvironments of different @entity2003 . Furthermore, @entity19 and @entity1573 embryo xenografts revealed that only PT cells showed a dispersed distribution pattern, closely associated to blood vessels. Consistent with cellular plasticity, simultaneous Rac and @entity39410 activation are required for the enhanced invasive capacity of PT cells. Moreover, Rho GTPase signaling modulators aVb3 and p27 play key roles in GIC invasiveness. Of note, p27 is upregulated in TM cells and inhibits @entity39410 activity. Gene silencing of p27 increased the invasive capacity of TM GICs. Additionally, b3 integrin is upregulated in PT cells. Blockade of dimeric integrin aVb3, a Rac activator, reduced the invasive capacity of PT GICs in vitro and abrogated the spreading of PT cells into @entity1573 embryos. Thus, our results describe the invasive features acquired by a unique subpopulation of GICs that infiltrate neighboring tissue.

title: Cellular plasticity confers migratory and invasive advantages to a population of XXXX -initiating cells that infiltrate peritumoral tissue.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'isolated tumor']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma']

answer: @entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']


abstract: Utilizing the experimental model in @entity329 , we explored the role of immunization in @entity105 . The animals, which were infected with @entity8072 (Opisthorchis viverrini), and administered a subcarcinogenic dose of @entity1232 , developed @entity5 . Pre-immunizing with a crude somatic antigen did not reduce @entity5 development, but accelerated @entity105 . Histopathological analysis of the @entity5 tissues was done once at week 30 and again at week 39 using H and E staining, immunostaining for the @entity42838 @entity5 suppressor phosphoprotein, and electron microscopy. Thirty weeks after immunization, the immunized hamsters developed @entity420 at a higher rate (71.43%) than the non-immunized group (20.00%). This rate (20.00%) increased to 63.64% by week 39. The @entity5 in the non-immunized group decreased in frequency from 80.00% (at week 30) to 36.36% (by week 39), suggesting the @entity5 progressed to @entity420 during the 9-week interval. Most of the observed @entity420 was well differentiated. Nearly all hamsters that tested positive for @entity5 also tested positive for @entity42838 immunostaining in the epithelia of the small bile ducts. The positive reaction for @entity42838 -immunostaining was localized in the rough endoplasmic reticulum, Golgi apparatus and perinuclear membranes. The electron micrographs of these positive @entity42838 -immunostained cells showed characteristics of @entity5 . The detection of @entity42838 in @entity5 development makes it a candidate as a @entity5 marker.

title: Ultrastructural and immunohistochemical analysis of cholangiocarcinoma in immunized @entity329 infected with Opisthorchis viverrini and administered with XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'small foci cancer', 'cancer', 'early cancer']

entities_list: @entity329 :: ('10036', 'Species') :: ['Syrian golden hamsters']

entities_list: @entity8072 :: ('6192', 'Species') :: ['liver flukes']

entities_list: @entity1232 :: ('MESH:D004128', 'Chemical') :: ['dimethylnitrosamine']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['tubular adenocarcinoma']

answer: @entity1232 :: (MESH:D004128,Chemical) :: ['dimethylnitrosamine']


abstract: OBJECTIVE: Pathological findings in neonatal @entity1545 associated with preterm birth include focal and/or diffuse @entity62 ( @entity62 ). Despite the heterogeneous nature of this condition, reactive astrogliosis and microgliosis are frequently observed. Thus, molecular mechanisms by which glia activation contribute to @entity62 were investigated. METHODS: Postmortem brains of neonatal @entity1545 were investigated to identify molecular features of reactive astrocytes. The contribution of astrogliosis to @entity62 was further tested in a @entity19 model in genetically engineered @entity19 . RESULTS: Activated @entity10433 signaling in reactive astrocytes was found to be a common feature in postmortem brains of neonatal @entity1545 . In a @entity19 model of neonatal @entity62 , conditional deletion of @entity10433 in astrocytes resulted in exacerbated @entity62 , which was associated with delayed maturation of oligodendrocytes. Mechanistically, the delay occurred in association with overexpression of transforming growth factor (TGF)b-1 in microglia, which in healthy controls decreased with myelin maturation in an age-dependent manner. @entity641 directly and dose-dependently inhibited the maturation of purified oligodendrocyte progenitors, and pharmacological inhibition of @entity641 signaling in vivo reversed the delay in myelin development. Factors secreted from @entity10433 -deficient astrocytes promoted elevated @entity641 production in cultured microglia compared to wild-type astrocytes. INTERPRETATION: These results suggest that myelin development is regulated by a mechanism involving crosstalk between microglia and oligodendrocyte progenitors. Reactive astrocytes may modify this signaling in a @entity10433 -dependent manner, preventing the pathological expression of @entity641 in microglia and the impairment of oligodendrocyte maturation.

title: XXXX -mediated astrogliosis protects myelin development in neonatal @entity1545 .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['WMI', 'white matter injury']

answer: @entity10433 :: (20848(Tax:10090),Gene) :: ['STAT3']


abstract: BACKGROUND: Malignant @entity2615 (MPM) is a very rarely encountered @entity5 in the normal population. OBJECTIVES: To investigate the variations in incidence of MPM in Southeast region of @entity233 . METHODS: We retrospectively investigated the data of 161 MPM @entity1 who were diagnosed from January 2000 to December 2009. The residential areas were determined according to asbestos exposure which plays a role in MPM etiology; previously reported as having asbestos (Region 1) and asbestos has not been determined previously (Region 2). RESULTS: One hundred nine (109) of the @entity1 (67.7%) included from the Region 1 and 52 of them (32.3%) included from the Region 2. MPM incidence of the last decade was 3.9/100,000 @entity1 /year for the whole region. In Region 1, 2000-2004 incidences was 12.6/100,000 @entity1 /year and 2005-2009 incidences was 14.9/100,000 @entity1 /year. In Region 2, 2000-2004 incidences was 0.4/100,000 @entity1 /year and 2005-2009 incidences was 1.0/100,000 @entity1 /year. According to the recently conducted incidence studies in our region, MPM incidence increased in region 1 and decreased in region 2. The number of @entity1 applying to our hospital has increased in the last three years. CONCLUSION: This increase, in Region 1 may be associated with continuous use of asbestos.

title: The incidence of XXXX has not decreased for the last twenty years in Southeast region of Anatolia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['pleural Mesothelioma']

answer: @entity2615 :: (MESH:D008654,Disease) :: ['mesothelioma']


abstract: BACKGROUND: @entity1 with @entity209 ( @entity209 ) are at increased risk of cardiovascular events. The impact of @entity209 on clinical events and @entity256 after drug-eluting stent placement is not well defined. METHODS: Two hundred and seventy-four consecutive @entity1 with 298 de-novo coronary lesions (<50 mm lesion length, reference diameter<3.5 mm) successfully treated with @entity3446 -eluting stents (SES) were enrolled in the study. Bifurcation lesions, left main lesions and ST-segment elevation @entity583 were excluded. @entity1 were categorized into three groups: (i) @entity6 , (ii) @entity209 without @entity6 , (iii) controls without @entity209 or @entity6 . @entity209 was defined as presence of > or =3 of the following criteria: @entity28 , @entity101 , @entity2298 , low high-density lipoprotein @entity165 , raised fasting @entity413 . RESULTS: One hundred and twenty-one @entity1 (44%) with 134 lesions had neither @entity209 nor @entity6 , 84 @entity1 (31%) with 89 lesions had @entity209 without @entity6 and 69 @entity1 (25%) with 75 lesions had @entity6 . Baseline angiographic parameters were comparable between the three groups. Clinically driven @entity75 revascularization rates and major adverse cardiac event rates at 12 months were 1, 1, 7% (P=0.039) and 3, 6 and 14% (P=0.032), respectively, for controls, @entity1 with @entity209 /no @entity6 and @entity6 @entity1 . Follow-up angiography at 6 months demonstrated late loss in lesion, which was 0.10+/-0.33 mm in the controls, 0.10+/-0.20 mm in @entity1 with @entity209 /no @entity6 and 0.36+/-0.66 mm in @entity6 @entity1 (P=0.009). CONCLUSION: @entity209 without @entity6 does not result in an increase in @entity75 revascularization, major adverse cardiac event rates or angiographic late loss compared with control @entity1 after implantation of SES in de-novo coronary lesions.

title: Impact of XXXX on clinical and angiographic outcome after @entity3446 -eluting stent implantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['target lesion']

entities_list: @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis']

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'MetS']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarcts']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']


abstract: The presence of @entity600 in @entity1 born after IVF was studied from a register consisting of practically all @entity1 born in Sweden after IVF, 1982--1997 (n = 9111). A further 64 @entity1 were studied using only medical records. It is a nation-wide study and has a population-based control group (n = 1,690,577) and relevant potential confounders have been taken into account. There was an @entity3887 of @entity600 registered in the Medical Birth Registry (n = 516, odds ratio = 1.47) but this @entity3887 disappeared when confounders were taken into consideration: year of birth, maternal age, parity, and period of unwanted childlessness (odds ratio = 0.89). For some specific conditions, an approximately 3-fold @entity3887 risk was seen: neural tube defects, alimentary @entity1146 , omphalocele, and @entity2650 (after intracytoplasmatic sperm injection). No @entity3887 risk for @entity2650 was seen after standard IVF. Various explanations for these findings are discussed. It is postulated that the @entity3887 risk for alimentary @entity1146 , like the @entity3887 risk for monozygotic twinning after IVF, is a direct consequence of the IVF procedure. The @entity3887 risk for @entity2650 after ICSI may be related to paternal subfertility with a genetic background. The absolute risk for a @entity600 in association with IVF is small.

title: XXXX in @entity1 born after IVF: a population-based study.

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['hypospadias']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformation', 'congenital malformations']

answer: @entity600 :: (MESH:D000014,Disease) :: ['Congenital malformations']


abstract: PURPOSE: To determine the mid-term clinical and radiographic impact of pedicle screw fixation in @entity1 with @entity1615 ( @entity1615 ). METHODS: A multicenter @entity1615 database was retrospectively queried to identify 99 consecutive @entity1 who underwent posterior spinal fusion using an all pedicle screw construct with a minimum of 5-year follow-up. Radiographic and clinical parameters were reviewed at regular intervals up to 5 years. RESULTS: The mean age was 14.4    2.0 years with 79 % being female. The mean preoperative major curve was 51.7    14.2   with a mean correction of 66 and 64 % at 2 and 5 years (p = 0.16). Pre-op thoracic kyphosis averaged 22.3    12.9   and was 18.4    10.6   at 5 years with no significant change from 2 years (p = 0.33). @entity6815 total and domain scores demonstrated significant improvements at 2 years, which were slightly decreased at 5 years (p = 0.06). @entity6815 scores of self-image (p = 0.99) and satisfaction (p = 0.18) were significantly improved after surgery with minimal change by 5 years. The change in @entity6815 total scores from 2 to 5 years was attributed to differences in @entity6815 scores of @entity158 and mental health (p < 0.05). CONCLUSIONS: Intermediate follow-up of @entity1 with @entity1615 treated with an all pedicle screw construct demonstrates maintenance of their coronal, and sagittal plane correction between 2- and 5-year follow-up. At 5 years, improvements in @entity6815 scores were consistent with 2-year values, except for a decline in @entity158 and mental health scores.

title: Five-year clinical and radiographic outcomes using pedicle screw only constructs in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1615 :: ('OMIM:181800', 'Disease') :: ['AIS', 'adolescent idiopathic scoliosis']

answer: @entity1615 :: (OMIM:181800,Disease) :: ['adolescent idiopathic scoliosis']


abstract: In the present study, we administered two @entity258 ( @entity258 ) to @entity35 during pregnancy and lactation and determined their effect on the ontogeny of select hepatic cytochrome P450 (P450) isoforms in their offspring. The L93 and LM76 @entity258 were derived from the American Society of Nutrition recommended AIN93G and a modified version of the AIN76A purified control diets, respectively. The @entity258 contained 8% crude protein in the form of casein, whereas the purified control diets contained 19% casein. A regular cereal-based diet (NP) was also included, and, therefore, a total of five groups were tested. Pups in all five groups were weaned onto a regular NP diet on postnatal day 28. Perinatal LPD altered the activities of a number of P450 isoforms in 28-day-old male and female offspring. However, nutritional rehabilitation abolished most of these changes as evidenced by lack of differences between the five groups in the activities of P450 isoforms in either 65- or 150-day-old offspring. Interestingly, 58-day-old female offspring in the LM76 group but not those in the L93 group exhibited shorter @entity8953 sleep time than the purified control group. However, @entity8953 hydroxylase activity and the amount of @entity13233 protein, an important P450 isoform involved in @entity8953 metabolism in females, were unchanged. This suggests that the decrease in @entity8953 sleep time in this group is not due to an increase in the activity of @entity8953 -metabolizing enzymes. In summary, perinatal @entity258 produced transient alterations in activities of select hepatic P450s and resulted in a gender- and diet-dependent long-term alteration in @entity8953 pharmacodynamics.

title: Effect of perinatal XXXX on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the @entity35 .

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['LPDs', 'low protein diets']

entities_list: @entity8953 :: ('MESH:D006591', 'Chemical') :: ['hexobarbital']

answer: @entity258 :: (MESH:D009800,Disease) :: ['low protein diets']


abstract: Although individual reports have indicated that a @entity174 of the first or second rib is predictive of injury to the @entity1514 aorta and its major branches, the results of a careful review of the literature do not support this contention. In @entity1 suffering blunt @entity130 , the risk of disruption of the aorta is not greater in @entity1 with @entity174 of the upper two ribs, compared with victims of @entity130 with @entity174 of other ribs or those without @entity174 of ribs. Clinical manifestations are often absent in @entity1 with disruption of the aorta or the innominate artery, but evidence of @entity548 is almost always present on roentgenograms of the chest. Widening of the mediastinum may not be apparent, but obliteration of the normal aortic contour is a sensitive finding in aortic transection. @entity1914 nearly always produces clinical or roentgenographic signs, or both. After blunt @entity764 , @entity1 with @entity174 of the first or second rib without clinical signs of @entity1317 and evidence of @entity548 on @entity1514 roentgenograms (with the @entity1 in an upright position when possible) do not need aortography to exclude @entity1317 . A few @entity1 with injury to the great vessels may have a normal @entity1514 roentgenogram on initial presentation to the hospital. After the correction of @entity3485 and stabilization of hemodynamic status, evidence of @entity548 should become apparent on subsequent @entity1514 roentgenograms. Repeat examinations must be performed and serial roentgenograms of the chest must be obtained for several days after injury to assess the possibility of unrecognized vascular @entity130 . If clinical or roentgenographic evidence of @entity1317 is revealed, arteriography is mandatory. @entity1514 scanning in @entity1 with evidence of @entity548 on plain film may be of value in selecting @entity1 for angiography, but additional experience must be obtained before such a protocol becomes an established policy.

title: XXXX of the upper ribs and injury to the great vessels.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['mediastinal hemorrhage', 'mediastinal bleeding']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic', 'Thoracic CT']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['trauma to the chest']

entities_list: @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury', 'occult vascular injury']

entities_list: @entity1914 :: ('MESH:D020212', 'Disease') :: ['Injury to the subclavian or carotid artery']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture']


abstract: The inability to predict if a metabolically bioactivated compound will cause @entity137 in later stages of drug development or post-marketing is of serious concern. One approach for improving the predictive success of compound @entity137 has been to compare the gene expression profile in preclinical models dosed with novel compounds to a gene expression database generated from compounds with known @entity137 . While this guilt-by-association approach can be useful, it is often difficult to elucidate gene expression changes that may be related to the generation of reactive metabolites. In an effort to address this issue, we compared the gene expression profiles obtained from animals treated with a soft-electrophile-producing hepatotoxic compound against corresponding @entity6189 labeled analogues resistant to metabolic processing. Our aim was to identify a subset of potential biomarker genes for hepatotoxicity caused by soft-electrophile-producing compounds. The current study utilized a known hepatotoxic compound @entity37409 ( @entity37410 ) and its two analogues labeled with deuterium at different positions to block metabolic oxidation at the @entity435 (d(1)) and @entity5498 (d(3)) moieties. Groups of @entity19 were dosed with each compound, and their livers were harvested at different time intervals. RNA was prepared and analyzed on Affymetrix GeneChip arrays. RNA transcripts showing statistically significant changes were identified, and selected changes were confirmed using TaqMan RT-PCR. Serum clinical chemistry and histopathologic evaluations were performed on selected samples as well. The data set generated from the different groups of animals enabled us to determine which gene expression changes were attributed to the bioactivating pathway. We were able to selectively modulate the metabolism of @entity37410 by labeling various positions of the molecule with a stable isotope, allowing us to monitor gene changes specifically due to a particular metabolic pathway. Two groups of genes were identified, which were associated with the metabolism of a certain part of the @entity37410 molecule. The metabolic pathway leading to the production of reactive @entity36419 resulted in distinct expression patterns that correlated with histopathologic findings. There was a clear correlation between the expression of certain genes involved in the cell cycle/apoptosis and inflammatory pathways and the presence of reactive metabolite. These genes may serve as potential genomic biomarkers of hepatotoxicity induced by soft-electrophile-producing compounds. However, the robustness of these potential genomic biomarkers will need to be validated using other hepatotoxicants (both soft- and hard-electrophile-producing agents) and compounds known to cause @entity99 before being adopted into the drug discovery screening process.

title: Identification of potential genomic biomarkers of hepatotoxicity caused by reactive metabolites of XXXX : Application of stable isotope labeled compounds in toxicogenomic studies.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity37409 :: ('MESH:C002950', 'Chemical') :: ['N-methylformamide']

entities_list: @entity6189 :: ('MESH:D003903', 'Chemical') :: ['deuterium']

entities_list: @entity36419 :: ('MESH:C008461', 'Chemical') :: ['methyl isocyanate']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['idiosyncratic liver toxicity']

entities_list: @entity435 :: ('CHEBI:42485', 'Chemical') :: ['formyl']

answer: @entity37409 :: (MESH:C002950,Chemical) :: ['N-methylformamide']


abstract: OBJECTIVE: Evidence is provided to clinicians and decision makers on the validity of ADA and WHO tests based on NDDG criteria for gestational @entity6 . MATERIALS AND METHODS: During 18 months, all pregnant @entity1 attending a University Hospital underwent a 50-g, 1-h NDDG GCT for universal screening (n = 1092). The following appointment consisted of a 75-g, 2-h GTT (WHO test), independently of the prior result. @entity1 with an abnormal 50-g and/or an abnormal 75-g, received a 100-g, 3-h GTT; subjects with only one abnormal 3-h GTT value were not included in the accuracy analysis. @entity1 whose diagnosis followed NDDG criteria received treatment. Obstetricians were not aware of ADA/WHO results. RESULTS: ADA sensitivity was 100% (95%CI 98.6, 100) and specificity, 98.1% (95%CI 97.6, 98.6), whereas WHO sensitivity was 57.6% (95%CI 55.9, 59.2) and specificity, 85.1% (95%CI 84.7, 85.6). ADA results remained similar independently of @entity28 and age, but performed better with a family history of @entity6 . Accuracy of WHO improved under selective screening, still the false negative rate ranged 40-56%. CONCLUSIONS: We recommend replicating this validation process in other health service settings. Although WHO test is easier and less expensive than NDDG or ADA, caution is needed before deciding employment of such criteria in pregnant @entity1 .

title: Gestational XXXX : Validity of ADA and WHO diagnostic criteria using NDDG as the reference test.

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: @entity1843 is a disorder with a prevalence of 0.01 to 0.06 %. @entity1 between 16 and 36 years of age are most commonly affected by it. In the western hemisphere, the knee is affected by this progressive disorder in 75 % of the cases, specifically the medial femoral condyle (70 - 80 %). The etiology is uncertain, although @entity74 , micro-trauma, @entity74 and @entity63 have been implicated. Pathogenetically, @entity1843 is classified in four stages, whereas in stage one, there is merely a subchondrial @entity4 . Without therapy this could lead to stage 4, with a free osteochondral joint fragment. Treatment is analogous with the stage of the disorder. Whereas conservative treatment may yield full recovery during stage 1, starting in stage 2, invasive treatment should be considered. When the cartilage surface remains intact retrograde procedures are indicated. If the cartilage is injured anterograde therapies, like the chondral or osteochondral transplantation, should be used.

title: [ XXXX of the knee joint].

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity1843 :: ('MESH:D010008', 'Disease') :: ['Osteochondritis dissecans']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic defects', 'ossification disorders']

answer: @entity1843 :: (MESH:D010008,Disease) :: ['Osteochondritis dissecans']


abstract: OBJECTIVES: Treatment with second-generation antipsychotic (SGA) medications has been linked with increased rates of the @entity209 (i.e., @entity2299 , @entity28 , and @entity4854 ). Several sets of published recommendations now provide clinicians with guidelines for monitoring metabolic parameters in individuals with @entity161 treated with SGAs. However, few data are available regarding actual metabolic monitoring practices in this @entity1 population. The objectives of the study were to determine baseline lipid monitoring rates for individuals with @entity161 prescribed SGAs during the period prior to the publication of monitoring guidelines and to determine whether individuals with abnormal lipid levels received follow-up monitoring sooner than individuals with normal levels. METHOD: Lipid monitoring rates for 408 individuals with @entity161 who were prescribed SGAs from October 1999 to October 2003 were examined using administrative data from a Veterans Affairs facility. Survival analysis was used to examine time to follow-up lipid measurement and to compare time to follow-up measure for individuals with normal initial lipid levels versus those with elevated initial lipid levels. RESULTS: Eighty-five percent of individuals had at least 1 measurement for total @entity165 or @entity1674 in a 4-year period. Abnormal initial measurements predicted significantly earlier follow-up monitoring (p < .005 for total @entity165 , p < .05 for @entity1674 , p < .001 for low-density lipoprotein @entity165 ). However, median time to follow-up measure was 304 days (approximately 10 months) for individuals with elevated total @entity165 levels, which is too long for optimal clinical follow-up. CONCLUSION: Program managers and clinicians should assess adequacy of monitoring and support quality improvement initiatives in this area.

title: Lipid monitoring in @entity1 with XXXX prescribed second-generation antipsychotics.

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: MR images of 48 @entity1 with histologically confirmed benign and @entity5 were retrospectively compared with CT and bioptically/surgically obtained findings. In 47/48 @entity1 pathological changes of the pleura were visualized by increased signal intensities on T2-weighted and contrast enhanced T1-weighted MR images. This lead to a slightly improved sensitivity compared to CT, where pathological pleura findings were confirmed in 45/48 @entity1 . MRI was able to identify 24/28 confirmed @entity1143 , whereas CT was successful in 26/28 @entity1 . In two cases effusions not identified on CT were visible on T2-weighted MRI. 4 @entity1143 were missed with MRI.. On CT images differentiation of pleural changes vs effusions or adjacent lesions of lung parenchyma was successful in 20/28 and in 17/23 cases, respectively. Contrast enhanced T1-weighted images achieved the highest diagnostic accuracy with 22/28 and 20/23 cases, respectively. Signal intensities on MRI were unsuitable as sole criterion for the differentiation of benign and @entity5 . Contour and pattern of spreading of pleural changes were helpful in differential diagnosis. Nodular changes, thickening of more than 10 mm and mediastinal, circumferential and entire hemithoracic affection of the pleura were suggestive for malignant @entity456 . Infiltration of the diaphragm and the chest wall were most indicative for @entity5 ; here MRI (2/2 resp. 18/19 cases) was superior to CT (0/2 resp. 14/19 cases). CT was superior in the detection of @entity730 and osseous destruction.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX in magnetic resonance tomography (MRT)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant diseases of the pleura', 'malignancy']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['pleural calcifications']

entities_list: @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural disease']

answer: @entity456 :: (MESH:D010995,Disease) :: ['Pleural diseases']


abstract: BACKGROUND: @entity0 ( @entity0 ) is a rare, highly aggressive form of @entity0 . The mechanism of @entity0 remains unknown. We sought to evaluate potential genetic risk factors for @entity0 and whether or not the @entity0 cell lines SUM149 and SUM190 demonstrated evidence of @entity1800 . METHODS: We performed single nucleotide polymorphism (SNP) genotyping for 2 variants of the ribonuclease (RNase) L gene that have been correlated with the risk of @entity263 due to a possible viral etiology. We evaluated dose-response to treatment with interferon-alpha ( @entity3027 ); and assayed for evidence of the putative @entity1 @entity5 virus (HMTV, which has been implicated in @entity0 ) in SUM149 cells. A bioinformatic analysis was performed to evaluate expression of @entity30615 in @entity0 and non- @entity0 . RESULTS: 2 of 2 @entity0 cell lines were homozygous for @entity30615 common missense variants 462 and 541; whereas 2 of 10 non- @entity0 cell lines were homozygous positive for the 462 variant (p= 0.09) and 0 of 10 non- @entity0 cell lines were homozygous positive for the 541 variant (p = 0.015). Our real-time polymerase chain reaction (RT-PCR) and Southern blot analysis for sequences of HMTV revealed no evidence of the putative viral genome. CONCLUSION: We discovered 2 SNPs in the @entity30615 gene that were homozygously present in @entity0 cell lines. The 462 variant was absent in non- @entity0 lines. Our discovery of these SNPs present in @entity0 cell lines suggests a possible biomarker for risk of @entity0 . We found no evidence of HMTV in SUM149 cells. A query of a panel of @entity1 @entity0 and non- @entity0 samples showed no difference in @entity30615 expression. Further studies of the @entity30615 462 and 541 variants in @entity0 tissues are warranted to validate our in vitro findings.

title: In Vitro Assessment of the Inflammatory Breast Cancer Cell Line SUM 149: Discovery of 2 Single Nucleotide Polymorphisms in the XXXX Gene.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['IBC carcinogenesis', 'breast cancer', 'Inflammatory breast cancer', 'IBC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['mammary tumor']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

answer: @entity30615 :: (6041,Gene) :: ['RNase L']


abstract: AIMS: Elevated levels of pro-inflammatory cytokine @entity636 ( @entity636 ) are associated with @entity101 @entity792 ; however, the connection between @entity636 and @entity101 is unknown. We hypothesized that @entity636 increases blood pressure by decreasing endothelial @entity842 production. METHODS AND RESULTS: Acute treatment of endothelial cells with @entity636 caused a significant increase in phosphorylation of the inhibitory endothelial @entity842 (NO) synthase residue @entity1889 495 (eNOS Thr495). Of the kinases known to phosphorylate eNOS Thr495, only inhibition of @entity22636 prevented the @entity636 -induced increase. @entity636 caused a threefold increase in the @entity22636 activator @entity22296 , and this was prevented by an @entity636 neutralizing antibody. In isolated @entity19 aortas, @entity636 significantly increased eNOS Thr495 phosphorylation, induced @entity22296 expression, and decreased NO-dependent relaxation responses, all of which were prevented by either an @entity636 neutralizing antibody or inhibition of @entity22636 . In @entity19 , @entity636 treatment for 1 week significantly increased systolic blood pressure and this was associated with decreased aortic NO-dependent relaxation responses, increased eNOS Thr495 phosphorylation, and increased @entity22296 expression. Inhibition of @entity22636 prevented the @entity101 caused by @entity636 . CONCLUSION: These data demonstrate that @entity636 activates @entity22296 / @entity22636 leading to @entity409 and @entity101 . Inhibitors of @entity636 or @entity22636 may prove useful as anti- @entity101 drugs in @entity636 -associated @entity792 .

title: Interleukin-17 causes XXXX -mediated @entity409 and @entity101 .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

answer: @entity22636 :: (19878(Tax:10090),Gene) :: ['Rho-kinase']


abstract: OBJECTIVE: To evaluate the safety and efficacy of Enterprise stent in the treatment of severe symptomatic basilar @entity2791 . METHODS: All @entity1 who underwent Enterprise stent for the treatment of symptomatic basilar @entity731 in our center from Nov. 2011 to Nov. 2014 were enrolled in the study. Preoperative and postoperative dual antiplatelet drugs and intensive lipid-lowering therapy were given to all the @entity1 . Multi-modality imaging guiding for stent angioplasty was performed in all the @entity1 , including head MRI or CT, CT or MRI perfusion, high resolution MRI for plaque analysis and angiography. Angiography after 6 months was recommended. The main outcome parameters were any @entity64 or @entity204 within 30 days, @entity64 recurrence in the basilar artery blood supply area during the follow-up period and in-stent @entity256 . RESULTS: A total of 35 cases were enrolled in the study with operation technical success rate of 100%. The average preoperative and postoperative @entity850 rate was (83.0  10.1)% and (28.1  8.9)%. The main perioperative complication and mortality rate was 0. The average follow-up period was (10.6  7.9) months. During follow-up period, only 2 cases (5.7%) of TIA related to the stented artery were observed. In @entity1 with follow-up period more than 6 months, 17 cases (56.7%) underwent cerebral angiography. @entity256 rate was 17.6%. One @entity1 with in-stent @entity256 suffered from @entity2806 and received another Enterprise stenting successfully. CONCLUSION: Long term follow-up results show that Enterprise stent for the treatment of symptomatic basilar artery severe @entity850 is safe and recurrence of @entity64 can be prevented effectively.

title: [A long-term follow-up results of Enterprise stent in treatment of severe symptomatic basilar XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['transient cerebral ischemia']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['artery atherosclerosis stenosis']

entities_list: @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis', 'Restenosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['artery atherosclerotic stenosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity731 :: (MESH:D050197,Disease) :: ['artery atherosclerotic stenosis']


abstract: PURPOSE: To examine the features of @entity1714 -related optical coherence tomography (OCT) findings in a population-based setting. DESIGN: Population-based study. @entity1 : The Beijing Eye Study 2011 included 3468 subjects with an age of 50 years or more. METHODS: The @entity1 underwent a detailed ophthalmic examination including OCT with enhanced depth imaging of the macula. MAIN OUTCOME MEASURES: Optical coherence tomography features of the macula in highly myopic eyes defined by a @entity2516 or less or an axial length of 26.5 mm or more. RESULTS: Readable OCT images were available for 6530 eyes (94.5%) of 3278 @entity1 . The most common change in the macula was maculoschisis (0.8  0.1%), followed by @entity20699 (0.7  0.1%), disruption of the photoreceptor inner segment/outer segment interface (0.6  0.1%), epiretinal membranes (0.6  0.1%), macular defects in Bruch's membrane (0.3  0.1%), clumping of the retinal pigment epithelium (0.2  0.1%), @entity1104 (0.2  0.1%), and macular holes in 2 eyes (0.1  0.1%). Prevalence of any @entity1020 per eye was 112 of 6530, or 1.71  0.16% (95% confidence interval [CI], 1.40-2.03). After adjustment for longer axial length (P<0.001; odds ratio [OR], 2.68; 95% CI, 1.97-3.64) and myopic @entity2516 (P<0.001; OR, 0.63; 95% CI, 0.55-0.73), presence of any @entity1020 was not significantly associated with any systemic variables (all P>= 0.05), including biochemical blood examination and ocular parameters. Best-corrected visual acuity was associated significantly with the absence of a disruption of the photoreceptor inner segment/outer segment interface (P<0.001), epiretinal membranes (P<0.001), and macular holes (P<0.001) after adjustment for age and cylindrical @entity2516 . CONCLUSIONS: Based on OCT examination, the most common macular change in highly myopic eyes was maculoschisis, followed by @entity20699 , disruption of the photoreceptor inner segment/outer segment interface, epiretinal membranes, macular defects in Bruch's membrane, clumping of the retinal pigment epithelium, @entity1104 , and macular holes. The most important macular changes with a negative effect on best-corrected visual acuity were a disruption of the photoreceptor inner segment/outer segment interface and epiretinal membranes.

title: XXXX imaged by optical coherence tomography: the beijing eye study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS']

entities_list: @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error of  -6 diopters', 'refractive error']

entities_list: @entity20699 :: ('MESH:D020255', 'Disease') :: ['incomplete posterior vitreous detachment']

entities_list: @entity1104 :: ('MESH:D000267', 'Disease') :: ['vitreofoveal adhesion']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['myopic maculopathy']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['Myopic maculopathy']


abstract: It has been proposed that opioid agonist efficacy may play a role in tolerance and the regulation of opioid receptor density. To address this issue, the present studies estimated the in vivo efficacy of three opioid agonists and then examined changes in spinal mu-opioid receptor density following chronic treatment in the @entity19 . In addition, tolerance and regulation of the trafficking protein @entity12851 were determined. To evaluate efficacy, the method of irreversible receptor alkylation was employed and the efficacy parameter tau estimated. @entity19 were injected with the irreversible mu-opioid receptor antagonist @entity37688 (0.32-25.6 mg/kg, i.p), and 24 h later, the analgesic potency of s.c. @entity1286 , @entity1288 and @entity7240 were determined. @entity37688 dose-dependently antagonized the analgesic effects of @entity1286 , @entity7240 and @entity1288 . The shift to the right of the dose-response curves was greater for @entity1286 and @entity1288 compared to @entity7240 and the highest dose of @entity37688 reduced the maximal effect of @entity1286 and @entity1288 , but not @entity7240 . The order of efficacy calculated from these results was @entity7240 > @entity1286 > @entity1288 . Other @entity19 were infused for 7 days with @entity1288 (10-150 mg/kg/day, s.c.) or @entity7240 (50-250 microg/kg/day, s.c.) and the analgesic potency of s.c. @entity1286 determined. The low efficacy agonist ( @entity1288 ) produced more tolerance than the high efficacy agonist ( @entity7240 ) at equi-effective infusion doses. In saturation binding experiments, the low efficacy opioid agonists ( @entity1286 , @entity1288 ) did not regulate the density of spinal mu-opioid receptors, while @entity7240 produced approximately 40% reduction in mu-opioid receptor density. Furthermore, @entity7240 increased spinal @entity12851 abundance, while @entity1288 did not produce any significant change in @entity12851 abundance. Overall, these data indicate that high efficacy agonists produce less tolerance at equi-effective doses. Furthermore, increased efficacy was associated with mu-opioid receptor downregulation and @entity12851 upregulation. Conversely, lower efficacy agonists produced more tolerance at equi-effective doses, but did not regulate mu-opioid receptor density or @entity12851 abundance. Taken together, these studies indicate that agonist efficacy plays an important role in tolerance and regulation of receptors and trafficking proteins.

title: Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and XXXX .

entities_list: @entity1288 :: ('MESH:D010098', 'Chemical') :: ['oxycodone']

entities_list: @entity7240 :: ('MESH:D005048', 'Chemical') :: ['etorphine']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity37688 :: ('MESH:C076806', 'Chemical') :: ['Clocinnamox', 'clocinnamox']

answer: @entity12851 :: (13430(Tax:10090),Gene) :: ['dynamin-2']


abstract: OBJECTIVE: The aim of this study was to review our experience with diagnosis and surgical management of @entity1518 in adult @entity1 . @entity1 AND METHODS: A retrospective review of the surgical outcome of adults with @entity1518 was performed. Twelve @entity1 were observed and treated between July 1996 and July 2006 (4 @entity1 and 8 @entity1 ; the mean age of the @entity1 was 28.5 years). Surgical outcomes, including @entity260 , @entity204 , and resolution of preoperative symptoms, were measured. RESULTS: A diagnosis of @entity1518 was made preoperatively in five @entity1 by upper gastrointestinal contrast study, barium enema, or computed tomography scan. The @entity154 was discovered incidentally at laparotomy in seven @entity1 . All cases were proved to be @entity1518 intraoperatively. Nine @entity1 underwent laparotomy and three underwent laparoscopic surgery (one converted to an open procedure). Follow-up ranged from 2 months to 118 months. Three @entity1 had complications: one had wound @entity281 , one had delayed @entity356 , and one developed @entity2616 . There were only two recurrences detected and one @entity1 with recurrence required reoperation. No one died. CONCLUSIONS: @entity1518 is a rare but important cause of @entity490 in adults. It may present with chronic or acute symptoms. Laparotomy and laparoscopy are alternative and feasible techniques with low rates of complications for the treatment of @entity1518 in adults.

title: Surgical management of XXXX in adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity2616 :: ('MESH:D045823', 'Disease') :: ['adhesive ileus']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1518 :: ('MESH:C562835', 'Disease') :: ['Intestinal malrotation', 'intestinal malrotation', 'malrotation']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric emptying']

answer: @entity1518 :: (MESH:C562835,Disease) :: ['intestinal malrotation']


abstract: It has been shown previously that the antero-inferior cortex is subjected to maximal tensile stress during a fall onto the greater trochanter. We have recently shown that in cases of @entity2249 , cortical thinning and porosity is greatest in the anterior and antero-inferior region of the femoral neck. To investigate whether this is due to increased remodeling, we have quantified surface-based parameters associated with Haversian remodeling in femoral neck biopsies from @entity1 with intracapsular @entity173 and post-mortem controls. Cryostat sections of chilled biopsies were reacted for either @entity5272 -resistant acid phosphatase (TRAP) or @entity623 ( @entity623 ) activity. Proportions of active canals were determined in each quadrant (inferior, anterior, superior, posterior) of the femoral neck. The biopsies were then embedded in @entity11379 to permit histomorphometry using Goldner's and Solochrome sections. In the cases there was no significant increase in the proportion of canals undergoing remodeling in the cortex as a whole (p = 0.846), but the regional distribution of remodeling was markedly different from that in the controls. In the anterior cortex, the proportion of canals undergoing remodeling was increased by 56% (p = 0.0087); in contrast there was a relative decrease of 35% in the superior region (p = 0.0047). In the anterior cortex of cases there were 76% and 42% increases in the proportions of eroded (p = 0.019) and osteoid-bearing (p = 0.041) canals, respectively. In the superior region, the decrease in the proportion of remodeling sites was due to a marked decrease in canals with an osteoid surface (51%; p = 0.0031). Covariance analysis with cortical porosity as the dependent variable showed that porosity was significantly dependent on the regional distribution of eroded (p = 0.033) but not on the distribution of forming (p = 0.153) canals (R(2)adj = 0.51). Cellular levels of TRAP and @entity623 were significantly elevated in the anterior region of cases compared with the controls (TRAP 55%, p = 0.006; @entity623 36%, p = 0.003). For the posterior and inferior regions there were no marked differences in cellular TRAP and @entity623 levels compared with control values. These data show that the increased cortical thinning and increased porosity we have previously observed in the anterior cortex in cases of @entity173 are associated with increased indices of Haversian remodeling. These findings are consistent with the hypothesis that, in cases of @entity173 , remodeling imbalance in the anterior cortex is a continuing process up to the time of @entity174 and is due to increased osteoclastic cellular activity associated with an osteoblastic response that is inadequate to prevent @entity604 .

title: Intracapsular XXXX : increased cortical remodeling in the thinned and porous anterior region of the femoral neck.

entities_list: @entity5272 :: ('MESH:C029768', 'Chemical') :: ['tartrate']

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['femoral neck fracture']

entities_list: @entity11379 :: ('CHEBI:25218', 'Chemical') :: ['methacrylate']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture']

entities_list: @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']

answer: @entity173 :: (MESH:D006620,Disease) :: ['hip fracture']


abstract: @entity3900 ( @entity3900 ) plays a major role during acrosomal exocytosis (AE) in @entity1 spermatozoa, but the identity of @entity3900 subtypes present in spermatozoa remains elusive. This study explored whether secretory @entity3900 Group IID ( @entity18471 ) isoform is present in @entity1 spermatozoa and whether it is involved in AE. Localization and expression of @entity18471 in @entity1 spermatozoa were explored by immunofluorescence staining and Western blot analysis. Occurrence of AE was evaluated by triple staining, and @entity1426 (AA) levels were quantified by gas chromatography-mass spectrometry. Sperm motion parameters and hyperactivation were analyzed by computer-assisted sperm analysis. @entity18471 was localized in the postacrosomal region of the head and the midpiece of tail in @entity1 sperm. A 16-kd protein band was detected by Western blotting in sperm extracts. @entity1420 -induced AE was significantly inhibited in a concentration-dependent manner using a @entity18471 neutralizing antibody. The increase in AA levels seen during @entity1420 -stimulated exocytosis was significantly abrogated by the antibody. The @entity18471 antibody significantly inhibited hyperactivation, sperm curvilinear velocity, and amplitude of lateral head displacement, but it did not affect the proportion of motile sperm. In conclusion, @entity18471 is present at the head and midpiece in the @entity1 sperm, and activation of such @entity18471 seems to be involved in AE. Therefore, @entity18471 isoform plays a functional role during the AE in @entity1 sperm.

title: Secretory XXXX group IID Is involved in @entity1420 -induced acrosomal exocytosis of @entity1 spermatozoa.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'human']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

answer: @entity3900 :: (151056,Gene) :: ['phospholipase A2']


abstract: Among identified @entity1104 molecules, the @entity1196 on neutrophils enables the first step of leukocyte adherence to activated endothelial cells. To allow firm @entity1104 of neutrophils, @entity1196 is then split off the cell membrane. It was hypothetized that an increase of the constitutively high serum level of soluble @entity1196 may indicate an ongoing pathological neutrophil sequestration to the endothelial cells associated with activation and injury of the cells. To evaluate this hypothesis, sL-selectin serum levels and neutrophil @entity1196 expression of healthy volunteers (group A, n = 15), as well as of surgical @entity1 , were investigated. Group B (n = 26) included @entity1 subjected to elective limb surgery (mean operation time, 122 min), and group C (n = 45) comprised @entity130 @entity1 . sL-selectin serum levels were measured daily over a 14-day period. Neutrophil @entity1196 expression was evaluated by FACS analysis using the humanized anti- @entity1196 antibody HuDreg 55 over a period of 3 days at minimum in both experimental groups. The binding of sL-selectin to endothelial cells was also examined in vitro. Elective limb surgery resulted in lower pre- and post-operative sL-selectin plasma levels (800-1,000 ng/mL) compared to healthy volunteers (1,100-1,200 ng/mL) with insignificant changes throughout the study period. @entity130 @entity1 revealed even lower sL-selectin levels (400-600 ng/mL). When these @entity1 were discriminated by the multiple organ dysfunction (MOD) score of Moore in +MOD (n = 9, ISS = 31.7) and -MOD (n = 36, ISS = 25.0), a significant difference became evident. In +MOD @entity1 sL-selectin levels remained on a low basis of 350 ng/mL, whereas in -MOD @entity1 the initial low sL-selectin level subsequently rose to 800 ng/mL, similar to that of elective surgery @entity1 . FACS analysis revealed a significant drop in neutrophil @entity1196 expression 24 h after @entity130 compared to normal. Also, +MOD and -MOD @entity1 were significantly discriminated by the @entity1196 expression at this time. The in vitro studies revealed evidence for binding of sL-selectin to endothelial cells independently on the presence of neutrophils. According to our data, increasing severity of the post-operative/posttraumatic course is associated with decreasing sL-selectin serum levels and also reduced neutrophil @entity1196 expression. In view of the in vitro results, this probably indicates competitive enhanced binding of sL-selectin to endothelial cells, thus masking the elevated activation of neutrophils and their ability for endothelial adherence.

title: The effect of XXXX on neutrophil @entity1196 expression and sL-selectin serum levels.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: OBJECTIVE: To elucidate the course and determinants of wheelchair exercise capacity in @entity1566 up to 5 years after discharge from inpatient rehabilitation, and to describe loss to follow-up. DESIGN: Prospective cohort study, with measurements at the start and discharge from inpatient rehabilitation, 1 and 5 years after discharge. SUBJECTS: A total of 225 wheelchair-dependent @entity1 with @entity1566 . METHODS: Random coefficient analysis of the course and determinants of peak aerobic power output (POpeak) and peak @entity26 uptake (VO2peak). RESULTS: A total of 162 @entity1 attended 1 or more peak exercise tests and were analysed. Significant changes were found for both VO2peak and POpeak between start and 5 years after discharge, and discharge and 5 years after discharge. No significant changes were found for VO2peak and POpeak between 1 year and 5 years after discharge. Age, gender, level and @entity75 were determinants for level of VO2peak and age, gender, and level of lesion for level of POpeak. No significant determinants were found for the course of wheelchair exercise capacity. The 63 @entity1 who were not analysed were older, and showed more @entity1 with a @entity1688 . CONCLUSION: Wheelchair exercise capacity of @entity1 with @entity1566 stabilizes at between 1 and 5 years after discharge. The @entity1 appear to be a positive selection of the total study group.

title: Wheelchair exercise capacity in XXXX up to five years after discharge from inpatient rehabilitation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'persons']

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['tetraplegia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['completeness of lesion']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: We studied MR images of the spine in a consecutive series of 100 @entity1 with acute compression of the spinal cord due to @entity3 . All @entity1 had documented neurological deficit and histologically proven @entity189 . MRI was used to localise bony metastatic involvement and soft-tissue impingement of the cord. A systematic method of documenting metastatic involvement is described. A total of 43 @entity1 had compression at multiple levels; 160 vertebral levels were studied. In 120 vertebrae (75%), anterior, lateral and posterior bony elements were involved. Soft-tissue impingement of the spinal cord often involved more than one quadrant of its circumference. In 69 vertebrae (43%) there was concomitant anterior and posterior compression. Isolated involvement of a vertebral body was observed in only six vertebrae (3.8%). We have shown that in most cases of acute compression of the spinal cord due to @entity3 there is coexisting involvement of both anterior and posterior structures.

title: The appearance on MRI of vertebrae in acute compression of the spinal cord due to XXXX .

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']