abstract: @entity11677 are most common midline @entity4 in head and neck region. It results from incomplete involution of thyroglossal duct. They present as midline painless swelling in neck. We have studied variation in their presentation. The retrospective study carried out in department of ENT in Gandhi Medical College Bhopal from Jan 2009 to Sept 2013. Objective of this study is, to study incidence of @entity11677 in different age and sex group and variation in presentation. Clinical records, medical records and histopathological records were studied. 10 @entity1 diagnosed as @entity11677 included in study. 10 @entity1 were found to be diagnosed as @entity11677 . Out of 10 pt. 6 were pediatric @entity1 and 4 were adults. 8 @entity1 presented with cyst while 2 presented with @entity292 . Out of 10 @entity1 3 presented with suprahyoid, 2 at the level of hyoid and 5 had infrahyoid presentation. 7 @entity1 undergone sistrunk operation procedure while 3 undergone simple excision. Out of 3 @entity1 who undergone simple excision 1 @entity1 develop recurrence. @entity11677 are one of the most common asymptomatic @entity4 and should be differentiated with other swellings with proper investigations.

title: XXXX , Variation in Presentation, Our Experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['congenital swelling', 'midline neck swelling']

entities_list: @entity11677 :: ('MESH:D013955', 'Disease') :: ['Thyroglossal duct cysts', 'Thyroglossal Duct Cyst']

answer: @entity11677 :: (MESH:D013955,Disease) :: ['Thyroglossal Duct Cyst']


abstract: BACKGROUND/AIM: There is a strong evidence for the involvement of genetic factors in @entity2412 . The aim of our study was to investigate the role of molecular variants of the @entity2533 ( @entity2533 ) and the @entity12170 (transforming growth factor beta stimulated clone 22) genes in @entity2316 and @entity6 in @entity164 2 @entity6 . METHODS: A case-control study was conducted in 503 @entity1 and 400 healthy subjects. DNA samples were genotyped by polymerase chain reaction and restriction fragment length polymorphism methods. RESULTS: Among the @entity1 , 245 had @entity2316 , 195 had @entity989 , and 168 were free from complications. All subjects were genotyped for @entity12171 and @entity12172 polymorphisms of the @entity2533 gene and for -396 polymorphism of the @entity12170 gene. A significantly increased frequency of the CC genotype of the @entity12171 polymorphism was observed in @entity1 with @entity8 and @entity989 (33 and 48%, respectively, vs. 19 and 15%, respectively, in controls and @entity1 free from complications). The frequency of the C allele was also higher (0.58 for @entity8 and 0.64 for @entity989 vs. 0.42 in controls). The G allele of the @entity12170 polymorphism was associated with an increased risk of @entity2316 (frequency 0.15 vs. 0.07 and 0.06, respectively, in @entity1 free from complications and controls). An interaction was observed between the G allele of the @entity12170 polymorphism and the C-allele of the @entity2533 polymorphism. CONCLUSIONS: Our data suggest the association of @entity2533 @entity12171 gene polymorphism with an increased risk of @entity8 and @entity989 in @entity164 2 @entity6 @entity1 . It interacts with the @entity12170 gene involved in the @entity2533 signaling pathway, promoting the development of @entity2316 .

title: @entity2533 and @entity12170 gene polymorphisms and susceptibility to microvascular complications in XXXX 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity2533 :: ('7040', 'Gene') :: ['TGF-beta1', 'TGF-beta', 'transforming growth factor beta 1']

entities_list: @entity2412 :: ('MESH:D048909', 'Disease') :: ['diabetic microvascular complications']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: OBJECTIVES: @entity26 -enhanced MRI (OE-MRI) biomarkers have potential value in assessment of @entity1030 , but need further evaluation before treatment-induced changes can be interpreted. The objective was to evaluate how OE-MRI parameters of regional ventilation and @entity26 uptake respond to standard pharmacological interventions in @entity1030 , and how the response compares to that of gold standard pulmonary function tests. MATERIALS AND METHODS: @entity1030 @entity1 (n=40), mean FEV1 58% predicted normal, received single-dose inhaled @entity6410 9 g, or placebo, followed by 8 weeks treatment bid with a combination of @entity4184 and @entity6410 Turbuhaler(  ) 320/9 g or @entity6410 Turbuhaler(  ). OE-MRI biomarkers were obtained, as well as X-ray computed tomography (CT) biomarkers and pulmonary function tests, in a two-center study. An ANCOVA statistical model was used to assess effect size of intervention measurable in OE-MRI parameters of lung function. RESULTS: OE-MRI data were successfully acquired at both study sites. 8-week treatment with @entity4184 / @entity6410 significantly decreased lung wash-out time by 31% (p<0.01), decreased the change in lung @entity26 level upon breathing pure @entity26 by 13% (p<0.05) and increased @entity26 extraction from the lung by 58% (p<0.01). Single-dose @entity6410 increased both lung wash-out time (+47%, p<0.05) and lung oxygenation time (+47%, p<0.05). FEV1 was improved by single-dose @entity6410 (+12%, p<0.001) and 8 weeks of @entity4184 / @entity6410 (+ 18%, p<0.001), consistent with published studies. CONCLUSIONS: In @entity1030 , OE-MRI parameters showed response to both single-dose bronchodilatory effects of a b2-agonist, @entity6410 , and 8-week treatment with an inhaled @entity228 , @entity4184 , and the measurements are feasible in a small-scale multi-center trial setting.

title: Feasibility assessment of using @entity26 -enhanced magnetic resonance imaging for evaluating the effect of pharmacological treatment in XXXX .

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen', 'Oxygen']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide']

entities_list: @entity6410 :: ('MESH:C012629', 'Chemical') :: ['formoterol']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['COPD']


abstract: This study estimated the @entity174 -related mortality and direct medical costs among postmenopausal @entity1 in Taiwan by @entity174 types and age groups by utilizing a nationwide population-based database. Results demonstrated that @entity173 constituted the most severe and expensive complication of @entity170 across @entity174 sites. INTRODUCTION: The aims of the study were to evaluate the risk of @entity204 and direct medical costs associated with @entity3604 by @entity174 types and age groups among postmenopausal @entity1 in Taiwan. METHODS: This nationwide, population-based study was based on data from the National Health Insurance Research Database in Taiwan. Female @entity1 aged 50  years and older in the @entity174 case cohort were matched in 1:1 ratio with randomly selected subjects in the reference control cohort by age, income-related insurance amount, urbanization level, and the Charlson comorbidity index. There were two main outcome measures of the study: age-differentiated mortality and direct medical costs in the first and subsequent years after @entity3604 events among postmenopausal @entity1 . The bootstrap method by resampling with replacement was conducted to generate descriptive statistics of mortality and direct medical costs of the case and control cohorts. Student's t tests were then performed to compare mortality and costs between the two cohorts. RESULTS: A total of 155,466 postmenopausal @entity1 in the database met the inclusion criteria for the @entity174 case cohort, including 22,791 @entity173 , 72,292 @entity174 , 15,621 upper end humerus (closed) @entity174 , 36,774 wrist @entity174 , and 7,988 @entity174 . Analytical results demonstrated that @entity1 experiencing @entity3604 were at considerable excess risk of @entity204 and incurred substantially higher treatment costs, notably for @entity173 . Furthermore, results also revealed that the risk of mortality increased with advancing age across the spectrum of @entity174 sites. CONCLUSIONS: The present study confirmed an excess mortality and higher direct medical costs associated with @entity3604 . Moreover, @entity173 constituted the most severe and expensive complication of @entity170 among @entity174 types.

title: The mortality and direct medical costs of XXXX among postmenopausal @entity1 in Taiwan.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture', 'osteoporotic fractures']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'vertebral fractures', 'multiple fractures', 'fracture']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures']

answer: @entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic fractures']


abstract: The aim of this study was to investigate the effects of lactation and conjugated @entity4722 (CLA) supplementation on adipocyte sizes of subcutaneous (s.c.) and visceral (VC) fat depots in primiparous dairy @entity291 during the first 105 d in milk ( @entity12315 ). German Holstein heifers (n=25) were divided into a control (CON) and a CLA group. From 1 @entity12315 until sample collection, CLA @entity291 were fed 100g of CLA supplement/d (about 6% of c9,t11 and t10,c12 isomers each), whereas the CON @entity291 received 100g of @entity844 mixture/d instead of CLA. The CON @entity291 (n=5 each) were slaughtered at 1, 42, and 105 @entity12315 , and the CLA @entity291 (n=5 each) were slaughtered at 42 and 105 @entity12315 . Adipose tissues from 3s.c. depots (tailhead, withers, and sternum) and from 3 VC depots (omental, mesenteric, and retroperitoneal) were sampled. @entity1710 - @entity1711 staining was done to measure adipocyte area ( m(2)). Retroperitoneal adipocyte sizes were mostly larger than adipocytes from the other sites, independent of lactation time and treatment. Significant changes related to duration of lactation were limited to retroperitoneal fat: adipocyte sizes were significantly smaller at 105 @entity12315 than at 1 @entity12315 in CON @entity291 . Adipocyte sizes were decreased in s.c. depots from the tailhead at 105 @entity12315 and from the sternum at 42 @entity12315 in CLA versus CON @entity291 , whereas for VC depots, adipocyte sizes were decreased in mesenteric fat at 42 and 105 @entity12315 , and in omental and retroperitoneal fat, at 105 @entity12315 in CLA versus CON @entity291 . Within the @entity13357 group, adipocyte sizes were smaller in the s.c. depot from the tailhead at 105 @entity12315 than at 42 @entity12315 . Adipocyte sizes and depot weights were significantly correlated in s.c. depots (r=0.795) in the CLA group and in retroperitoneal fat both in the CON (r=0.698) and the CLA (r=0.723) group. In conclusion, CLA-induced decreases in adipocyte size indicate lipolytic or antilipogenic effects of CLA, or both effects, on adipose tissue in primiparous dairy @entity291 .

title: Physiological and conjugated XXXX -induced changes of adipocyte size in different fat depots of dairy @entity291 during early lactation.

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin']

entities_list: @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']

answer: @entity4722 :: (MESH:D019787,Chemical) :: ['linoleic acid']


abstract: OBJECTIVE: To compare the immunogenicity of a licensed conventional whole-cell (WCL) and 13 diphtheria- @entity116 -acellular @entity5695 (DTaP) vaccines that differed in source, method of manufacture, and included antigens; all vaccines included diphtheria and @entity116 toxoids. METHODS: Healthy @entity1 were enrolled through six university-based vaccine and treatment evaluation units and were randomized to receive one of the study vaccines at 2, 4, and 6 months of age. Sera were obtained before the first immunization and 1 month after the third immunization and were analyzed for antibody to @entity5695 toxin (PT), filamentous hemagglutinin, fimbriae, pertactin, and diphtheria and @entity116 toxins. @entity3569 ovary cell toxin neutralization assays were performed, and levels of agglutinating antibodies were determined. RESULTS: Of 2342 @entity1 enrolled, 1942 contributed usable preimmunization and postimmunization serum specimens. Each vaccine produced significant increases in antibodies directed against the included antigens; postimmunization antibody titers differed significantly among the DTaP vaccines. For each evaluated antigen, the majority of DTaP vaccines produced antibody responses that equaled or exceeded those produced by WCL. For some antigens (eg, PT), mean antibody levels by vaccine correlated poorly with the quantity of antigen included in each vaccine; for others (eg., fimbriae), there was a close correlation. CONCLUSION: Although serologic correlates of @entity5695 immunity are not defined, it is clear that DTaP vaccines can stimulate immune responses that exceed those of licensed whole-cell vaccine with respect to the measured antibodies. Particularly for PT, immunogenicity seems to depend on factors in addition to antigen concentration, possibly including antigen derivation and formulation. No DTaP was most or least immunogenic with respect to all included antigens.

title: Comparison of 13 acellular XXXX vaccines: overview and serologic response.

entities_list: @entity3569 :: ('10029', 'Species') :: ['Chinese hamster']

entities_list: @entity5695 :: ('MESH:D014917', 'Disease') :: ['pertussis']

answer: @entity5695 :: (MESH:D014917,Disease) :: ['pertussis']


abstract: Plaques and tangles are highly and significantly enriched in herpes simplex ( @entity3307 ) binding proteins (by 11 and 15 fold respectively (P<4.47466E-39) and 132/341 (39%) of the known @entity3307 binding partners or associates are present in these structures. The classes involved include the majority (63-100%) of the known @entity3307 host protein carriers and receptors, 85-91% of the viral associated proteins involved in endocytosis, intracellular transport and exocytosis and 71% of the host proteins associated with the @entity3307 virion. The viral associated proteins found in plaques or tangles trace out a complete itinerary of the virus from @entity778 also binds to plaque or tangle components involved in apoptosis, DNA transcription, translation initiation, protein chaperoning, the ubiquitin/proteasome system and the immune network. Along this route, the virus deletes mitochondrial DNA, as seen in @entity195 , sequesters the neuroprotective peptide, @entity16987 , and interferes with key proteins related to amyloid precursor protein processing and signalling as well as beta-amyloid processing, microtubule stability and tau phosphorylation, the core pathologies of @entity195 . Amyloid-containing plaques or neurofibrillary tangles also contain a large number of complement, acute phase and immune-related proteins, and the presence of these pathogen defence related classes along with @entity3307 binding proteins suggests that amyloid plaques and tangles represent cemeteries for a battle between the virus and the host's defence network. The presence of the complement membrane attack complex in @entity195 suggests that complement mediated @entity528 may be a consequence of this struggle. @entity3307 @entity281 is known to increase @entity527 and tau phosphorylation and also results in cortical and hippocampal neuronal loss, cerebral shrinkage and @entity2414 in @entity19 . This survey supports the contention that herpes simplex @entity1800 contributes to @entity195 , in genetically predisposed individuals. Genetic conditioning effects are likely to be important, as all of the major risk promoting genes in @entity195 (apolipoprotein E, clusterin, complement receptor 1 and the @entity4357 binding clathrin assembly protein @entity4690 ), and many lesser susceptibility genes, are related to the herpes simplex life cycle. 33 susceptibility genes are related to the immune system. Vaccination or antiviral agents and immune suppressants should therefore perhaps be considered as viable therapeutic options, prior to, or in the early stages of @entity195 .

title: XXXX plaques and tangles: cemeteries of a pyrrhic victory of the immune defence network against @entity281 at the expense of complement and inflammation-mediated neuronal destruction.

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['entry to exocytosis and the virus']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['beta-amyloid deposition']

entities_list: @entity4357 :: ('MESH:D010716', 'Chemical') :: ['phosphatidylinositol']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease neurones", "Alzheimer's disease"]

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory deficits']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal lysis']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: STUDY OBJECTIVE: To describe the natural history of @entity2694 and its management in the emergency setting. DESIGN: Retrospective medical record review. SETTING: Inner-city integrated hospital system (four divisions) including one Level I @entity130 center. @entity1 : All cases of orbital floor @entity174 and @entity2694 from January 1, 1988, to December 31, 1993. RESULTS: The average @entity1 was aged 33 years, and the male-to-female ratio was 7 to 1. @entity130 was the underlying etiology in all @entity1 . Seventy-four percent of @entity1 required hospitalization, and 43% developed significant complications. Eighty-three percent were managed with antibiotics. @entity2694 was identified on conventional radiographs in 65% of cases. CONCLUSION: @entity2694 in the @entity2613 should prompt a careful search for associated injury. Consultation should be sought in the presence of orbital or @entity4858 . Antibiotic prophylaxis is not necessary for clean wounds.

title: XXXX : how common, how significant?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity4858 :: ('MESH:D005131', 'Disease') :: ['ocular injury']

entities_list: @entity2694 :: ('MESH:D009916', 'Disease') :: ['orbital emphysema', 'Identification of orbital emphysema', 'Orbital emphysema']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity2694 :: (MESH:D009916,Disease) :: ['Orbital emphysema']


abstract: SP/KLF (Specificity protein/Kr  ppel-like factor) transcription factors comprise an emerging group of proteins that may behave as @entity5 suppressors. Incidentally, many @entity5 that display alterations in certain KLF proteins are also associated with a high incidence of @entity7504 (V-Ki-ras2 Kirsten @entity35 sarcoma viral oncogene homologue) mutations. Therefore in the present paper we investigate whether SP/KLF proteins suppress @entity7504 -mediated cell growth, and more importantly, the potential mechanisms underlying these effects. Using a comprehensive family-wide screening of the 24 SP/KLF members, we discovered that @entity8061 , @entity8062 , @entity8063 , @entity8064 , @entity8065 , @entity8066 , @entity8067 , @entity8068 , @entity8069 and @entity8070 inhibit cellular growth and suppress transformation mediated by oncogenic @entity7504 . Each protein in this subset of SP/KLF members individually inhibits @entity1603 ( @entity1603 ) incorporation in @entity7504 oncogenic-mutant @entity5 cells. @entity8061 , @entity8064 , @entity8066 , @entity8067 , @entity8068 and @entity8070 also increase apoptosis in these cells. Using @entity8066 as a representative model for mechanistic studies, we demonstrate that this protein inhibits the ability of @entity5 cells to form both colonies in soft agar and @entity5 growth in vivo. Molecular studies demonstrate that these effects of @entity8066 are mediated, at least in part, through silencing cyclin A via binding to its promoter and leading to cell-cycle arrest in S-phase. Interestingly, similar to @entity8066 , @entity8068 and @entity8070 mechanistically share the ability to modulate the expression of cyclin A. Collectively, the present study stringently defines a distinct subset of SP/KLF proteins that impairs @entity7504 -mediated cell growth, and that mechanistically some members of this subset accomplish this, at least in part, through regulation of the cyclin A promoter.

title: A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of XXXX -mediated cell growth.

entities_list: @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', '5-bromo-2-deoxyuridine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumour']

answer: @entity7504 :: (24525(Tax:10116),Gene) :: ['KRAS']


abstract: BACKGROUND: @entity2477 is a frequent and the most common, primary, @entity5 of the orbit in adults. It is typically single and unilateral, considered not to recur after having been completely excised. Multiple orbital @entity2477 without signs of @entity14311 are rare. Multiple @entity2477 may recur after a complete excision and may exist with concurrent systemic @entity5 . @entity5 recurrence is supposed to develop from vasculature that is present already in response to a proliferate stimulus. CASE REPORT: A 39-year-old female with painless proptosis of the right orbit was found to have four @entity5 . The first orbitotomy was performed in 1984 by excising four @entity2477 . Six years later, another, the fifth one cavernous @entity2695 was totally excised from the same orbit. Nine years after the first operation, reorbitotomy was performed because of positive radiological and clinical signs of de novo @entity5 in the orbit. The operation did not confirm the tumorous tissue. The fourth orbitotomy was performed 24 years after the first operation and two @entity2477 were totally excised. CONCLUSION: This case show the possibility of cavernous @entity2695 recurrence after a previously totally excised @entity5 , separated more than two decades. A very long follow-up of the @entity1 operated for these @entity5 lesions is recommended.

title: Multiple XXXX of the orbit: separate occurrence within a 24-year period.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['orbital tumors', 'tumor', 'benign tumor', 'Tumor', 'tumors']

entities_list: @entity14311 :: ('MESH:C566283', 'Disease') :: ['hemangiomatosis']

entities_list: @entity2477 :: ('MESH:D006392', 'Disease') :: ['Cavernous hemangioma', 'cavernous hemangiomas']

answer: @entity2477 :: (MESH:D006392,Disease) :: ['cavernous hemangiomas']


abstract: Using corneal topography, we compared the corneal shape changes following superolateral incision @entity231 surgery with those following conventional superior incision surgery. In our superolateral incision procedure, a 6.5 mm limbal incision was made from the 9 o'clock to 11 o'clock meridians to avoid incising the superior limbus. One hundred four @entity1 were divided into two groups; Group 1 comprised 66 @entity1 who had surgery using the superolateral approach; Group 2 comprised 38 @entity1 who had surgery using the superior approach. The corneas were examined by keratometer and topographic modeling system preoperatively, and at one week and one, three, and six months postoperatively. Keratometric measurements showed that surgically induced @entity940 (SIA) in Group 1 was significantly less than that in Group 2 throughout the six-month observation. The standard SIA deviation in Group 1 was also smaller than that in Group 2, indicating a smaller degree of variability in the superolateral incision surgery. In the corneal topographic analysis, a color-coded map averaging all the Group 1 corneas at each interval showed a slight steepening in the central cornea in the 10 o'clock meridian one week after surgery. This surgically induced steepening disappeared by one month, and the corneal shape recovered its preoperative shape. In contrast, the Group 2 averaged map showed a marked steepening of the upper and lower corneas. The steepening gradually decreased but remained until three months after surgery. Superolateral incision surgery induced a smaller degree of change in the corneal shape, as well as in SIA, than superior incision surgery. The postoperative corneal shape changes disappeared rapidly after the superolateral incision, and the corneal shape soon stabilized and recovered its preoperative shape.

title: Corneal topographic analysis of superolateral incision XXXX surgery.

entities_list: @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: BACKGROUND: Female sex, old age, and time to cardioversion increase the risk of @entity1031 ( @entity1031 ) after cardioversion of @entity955 ( @entity955 )   <   48   h. The interaction of these variables is not known. We investigated the interaction of sex, age, and time to electrical cardioversion (ECV) on @entity1031 in anticoagulant-naive @entity1 with acute @entity955 . METHODS AND RESULTS: The primary outcome was a @entity1031 within 30 days following ECV. @entity1 were divided into three age groups and time to cardioversion into <12   h and >= 12   h in 4715 ECVs. @entity1031 occurred in 40 (0.8%) @entity1 . In multivariate analysis, female sex, time to ECV, and @entity455 were independent predictors of @entity1031 . For @entity1 <= 75 cardioverted within 12   h, the incidence of @entity1031 was low. In @entity1 >75 @entity1031 increased in both sexes and particularly in @entity1 (1.4% vs. 0.9%, p   =   0.03). When ECVs exceeded 12   h, the risk of @entity1031 was two- to four-fold higher in @entity1 in all age groups. CONCLUSIONS: The risk of @entity1031 increases substantially in @entity1 >75 and ECVs >= 12   h, particularly in @entity1 . Time to cardioversion should be added to risk-stratification of ECVs of acute @entity955 . Key messages The ideal timing of cardioversion is still unknown and not based on solid evidence. Delay to cardioversion >= 12   h should be added to the risk stratification of @entity955 . Female sex increases the risk of complications and @entity177 after electrical cardioversion of @entity955   <48   h, especially with age   >75 years and time to cardioversion exceeding 12   h.

title: Sex, age, and time to cardioversion. Risk factors for cardioversion of acute XXXX from the FinCV study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['failure of cardioversion']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic complications', 'TEC']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF', 'atrial fibrillation cardioversion']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: Immunotherapy (IT) has become an accepted therapeutic modality for a limited number of @entity5 types. One of the limiting factors in the use of @entity2047 ( @entity2047 ) has been dose-related @entity137 . We undertook these studies to study the effects of combined therapy on a @entity19 @entity320 . The B16 @entity320 was implanted in the right hindlimb of C57BL/6 @entity19 and therapy begun on day 3 (microscopic @entity5 model) or day 10 ( @entity5 model). Animals were divided into four groups: No therapy, local @entity221 ( @entity221 ) alone (45 degrees C x 15 minutes on days 3 and 6 or days 10 and 13), @entity221 + @entity2047 at 300,000 IU ip tid, and @entity221 + @entity2047 at 600,000 IU ip tid. We have shown in multiple previous experiments that @entity2047 alone at these doses has no effect on @entity5 growth; these groups were omitted. In the microscopic model, @entity5 in the no treatment group were an average of 400 mm2. Animals treated with @entity221 alone had a mean @entity5 size of 300 mm2. However, @entity5 in animals receiving both therapeutic modalities measured a mean of 100 mm2 (300,000 IU @entity2047 ip tid) and 80 mm2 (600,000 IU @entity2047 ip tid). In the @entity5 model, @entity5 in animals receiving no treatment were an average of 7.5 times larger than on day 10, in animals receiving @entity221 alone were an average of 5 times larger, animals receiving @entity2047 were 2.95 times larger (both dose levels). These results show that combined IT+ @entity221 therapy resulted in significantly (P < .05) reduced growth with both microscopic and macroscopic @entity5 compared to @entity221 alone or no therapy in a @entity19 subcutaneous @entity320 model using doses significantly lower than those usually needed to observe a therapeutic response with @entity2047 used alone. This study further supports the use of this combined modality approach in @entity1 with advanced @entity5 .

title: Combined local @entity221 and immunotherapy treatment of an experimental subcutaneous XXXX @entity320 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'macroscopic tumor', 'malignancies', 'tumors']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia', 'HT']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: INTRODUCTION: Idiopathic @entity10516 (IGM) is a rare benign inflammatory breast disease that presents with variable local manifestations. We describe here the different management protocols based on the clinical presentation of these @entity1 . METHODS: A retrospective review of 20 histopathologic confirmed cases of IGM seen over a period of 10 years was performed. RESULTS: The median age was 34 years (age range: 21-45 years). All were married, parous with history of breast feeding. Ill-defined mass mimicking @entity189 was the commonest presentation (70%); however, with the presence of signs of @entity32 like @entity158 (55%), redness (40%), and peau d'orange (40%), an inflammatory process appeared more likely. @entity1600 was infrequently seen (40%). Radiologic findings (mammography and ultrasound) were nonspecific. Histopathology showed the characteristic lobular distribution of @entity32 in all cases. Surgically, 7 @entity1 had abscess drainage with open biopsy, and 7 @entity1 had lumpectomy. Six @entity1 with diffuse breast involvement were diagnosed by core needle biopsy only. Microbial cultures showed no growth. Antibiotics were given empirically when signs of @entity32 where present. Two @entity1 needed further abscess drainage followed by persistent sinus excision 3-6 weeks later. The median follow-up was 24 months (range: 15-42 months). Seventeen @entity1 (85%) were recurrence-free, and 3 @entity1 (15%) were lost to follow-up. CONCLUSIONS: Management of IGM cases needs to be tailored according to the clinical presentation. Precise radiologic and pathologic data interpretation by a multidisciplinary breast team will facilitate diagnosis and minimize unnecessary intervention.

title: Idiopathic XXXX : a heterogeneous disease with variable clinical presentation.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'granulomatous inflammation']

entities_list: @entity10516 :: ('MESH:D058890', 'Disease') :: ['granulomatous mastitis']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['Axillary lymph node enlargement']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity10516 :: (MESH:D058890,Disease) :: ['granulomatous mastitis']


abstract: PURPOSE: We recently noticed the occurrence of both livedo and elevated anticardiolipin antibody levels in a small number of @entity1 with @entity1252 . The purpose of our study was two-fold: (1) to investigate whether anticardiolipin antibodies were more common in @entity1252 @entity1 with livedo than in those without; and (2) to determine if the features of @entity12287 (livedo and @entity66 ) also were found in @entity1 with @entity1252 . @entity1 AND METHODS: In this case-control study of @entity1252 @entity1 without significant @entity8 , 29 @entity1 with @entity12288 (cases) were compared clinically and immunologically with 29 @entity1 without livedo (controls). RESULTS: Both groups shared many disease characteristics and were similar in age and sex. However, they differed markedly in other respects. Elevated anticardiolipin antibody levels were significantly more common in the cases. Indeed, 81% of all cases from our study sample had elevated anticardiolipin levels. A history of @entity715 and @entity882 --clinical associates of the anticardiolipin antibody--was also significantly more common in cases than in controls. The relative odds of @entity12288 were 23-fold greater in those with elevated anticardiolipin levels than in those without these antibodies. The estimated proportion of livedo-positive @entity1 with elevated anticardiolipin antibodies in a general @entity1252 population without significant @entity8 was 0.77. CONCLUSION: The association between @entity12288 and @entity66 , originally described by Sneddon in otherwise healthy individuals, also applies to @entity1252 @entity1 . The presence of elevated anticardiolipin antibody levels in 10 of 11 such @entity1 suggests that the anticardiolipin antibody may be of pathogenetic importance in the manifestations of @entity12287 in @entity1252 and also possibly in the idiopathic form of this disease.

title: Clinical and immunologic features of XXXX in @entity1252 : a case-control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity12287 :: ('MESH:D018860', 'Disease') :: ["Sneddon's syndrome"]

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity12288 :: ('MESH:D054068', 'Disease') :: ['livedo reticularis']

answer: @entity12288 :: (MESH:D054068,Disease) :: ['livedo reticularis']


abstract: OBJECTIVES: The purpose of this study was to investigate whether serum interferon (IFN)-regulated chemokine and distinct cytokine response profiles are associated with clinical improvement in @entity1 with refractory inflammatory @entity121 treated with rituximab. METHODS: In a randomised, placebo-phase trial Rituximab in @entity5442 Trial (RIM), 200 refractory adult and paediatric @entity5442 subjects received rituximab. Following rituximab, clinical response and disease activity were assessed. Serum samples and clinical data were collected at baseline and several time-points after rituximab treatment. Multiplexed sandwich immunoassays quantified serum levels of IFN-regulated chemokines and other pro-inflammatory cytokines. Composite IFN-regulated chemokine and @entity1198 , Th2, Th17 and regulatory cytokine scores were computed. RESULTS: Baseline IFN-regulated chemokine, @entity1198 , Th2, Th17 and regulatory cytokine scores correlated with baseline physician global VAS, whereas the baseline @entity1198 , Th2 and Th17 cytokine scores correlated with baseline muscle VAS. We also found baseline IFN-regulated chemokine scores correlated with specific non-muscular targets such as baseline cutaneous (r=0.29; p=0.002) and pulmonary (r=0.18; p=0.02) VAS scores. Among all cytokine/chemokines examined, the baseline score of IFN-regulated chemokines demonstrated the best correlation with changes in muscle VAS at 8 (r=-0.19; p=0.01) and 16 weeks (r=-0.17; p=0.03) following rituximab and physician global VAS at 16 weeks (r=-0.16; p=0.04). In vitro experiments showed increased levels of @entity687 (p=0.04), @entity2842 (p=0.04), @entity650 (p=0.03), @entity1356 (p=0.04), @entity4047 (p=0.04), @entity688 (p=0.02), @entity1199 (p=0.04) and IFN-y (p=0.02) in supernatants of @entity6800 stimulated PBMCs from non-responder compared to @entity1 responders to rituximab. CONCLUSIONS: IFN-regulated chemokines before treatment is associated with improvement in disease activity measures in refractory @entity5442 @entity1 treated with rituximab.

title: Interferon-regulated chemokine score associated with improvement in disease activity in refractory XXXX @entity1 treated with rituximab.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5442 :: ('MESH:D009220', 'Disease') :: ['Myositis', 'myositis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy']

answer: @entity5442 :: (MESH:D009220,Disease) :: ['myositis']


abstract: Clinical differentiation between @entity583 and peptic @entity1066 perforation may sometimes be difficult. We report on a sixty-five year-old @entity1 who presented at the Emergency Department with upper @entity490 and local tenderness suggestive of acute perforation of a @entity2275 . However, the initial electrocardiogram (ECG) showed @entity4156 . Although @entity490 is a major symptom of @entity4156 the history of @entity3621 and abdominal findings on admission of our @entity1 required further exploration. The first plain abdominal radiograph was inconspicuous, therefore we performed a gastroscopy, which showed a @entity2275 . The second plain abdominal radiograph revealed air in the peritoneal cavity as sign of perforation. Echocardiography, ECG and the increase of heart enzymes confirmed acute inferior wall @entity1188 . After successful surgical treatment of the perforated @entity1066 the @entity1 recovered and progressed satisfactorily at the intensive care unit. He was discharged after three weeks and remains in good health. This case shows that rapid diagnosis and good interdisciplinary therapeutic management prevented a fatal outcome of @entity583 and concomitant @entity2275 perforation in an elderly @entity1 .

title: [Concomitant perforated @entity1066 and acute XXXX --a diagnostic challenge in emergency medicine].

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity4156 :: ('MESH:D056989', 'Disease') :: ['acute inferior wall myocardial infarction']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer', 'prepyloric gastric ulcer']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarct']


abstract: OBJECTIVE: To investigate the clinical characteristics and the effect of drug treatment for sudden @entity393 with @entity9468 or @entity1296 . METHODS: In a prospective, randomized, single blinded randomized multicenter clinical study, @entity1 with @entity2459 , ranging in age from 18 to 65 years old, with a duration less than 2 weeks, and with no any medical treatments were collected. In accordance with the hearing curve, those @entity1 were divided into four types, i.e., low and intermediate frequency descent type; high frequency descent type; fall flat type; and @entity2319 . Each type was treated by four different treatment options, according to the unified design of the random table, and randomly selected one of the options for treatment. The efficacy of the @entity1 with @entity2459 with @entity9468 and @entity1296 was analyzed statistically after the follow-up for 4 weeks. SPSS 13.0 software was used to analyze the data. RESULTS: In August 2007 to October 2011, 33 hospitals in the country included 1 024 @entity1 with @entity2459 in line with the inclusion criteria, of whom 296 (28.91%) were accompanied by @entity9468 / @entity1296 symptoms, 126 were males and 170 were females, with an average age of (41.2    13.5) years old. types of the different audiometric curves of @entity2459 , the occurrence of @entity2319 with @entity9468 / @entity1296 was the highest (44.93%), followed by flat down type (25.87%), high frequency descent type (21.28%) and low intermediate frequency descent type (18.54%). After the standard treatment, the @entity9468 and @entity1296 symptoms of the @entity2459 @entity1 @entity2402 , and the hearing in each group was obviously improved. The hearing curative effect on @entity1 accompanied by @entity9468 / @entity1296 of low frequency and intermediate frequency descent type was the best, and the total efficiency can reach up to 94.74%, with the cure rate of 68.42%; followed by flat type, in which the total effective rate was 80.76%, with the recovery rate of 22.12%; and the effects on @entity1 in high frequency descent type and @entity2319 effect were relatively poor, in which the total effective rates were 70.00% (recovery rate of 10.00%) and 65.32% (recovery rate of 5.65%), respectively. The total effective rate of @entity1 with @entity2459 associated with halo had no statistical significance (P > 0.05), in comparison to that of @entity1 without halo; but, the cure rate of @entity1 with no @entity9468 / @entity1296 of @entity2319 and the high frequency decreased @entity1 with @entity2459 was significantly higher than that of @entity9468 / @entity1296 @entity1 , with a statistical difference (P < 0.05). CONCLUSIONS: The @entity1 with @entity2459 in each type have a certain proportion of @entity9468 / @entity1296 , especially the deaf type. The possibility of hearing complete recovery in @entity1 with @entity9468 / @entity1296 was significantly lower than that without @entity9468 / @entity1296 .

title: [Analyses of clinical features and efficacy of @entity2459 with @entity9468 and XXXX ].

entities_list: @entity2402 :: ('MESH:D010015', 'Disease') :: ['could disappear']

entities_list: @entity2319 :: ('MESH:D003638', 'Disease') :: ['complete deafness', 'total deafness', 'total deafness type']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity2459 :: ('MESH:D003639', 'Disease') :: ['sudden deafness']

answer: @entity1296 :: (MESH:D004244,Disease) :: ['dizziness']


abstract: AIM: Few studies have investigated the role of the @entity9164 and @entity4192 genes in @entity2909 . Therefore, in the current study the distribution of these genotypes in Iranian @entity1 and susceptibility to @entity2909 was investigated. METHODS: Blood samples of 50 @entity1 with @entity2909 and 50 healthy individual controls were collected in this cross-sectional study. Genomic DNA was extracted, and subsequently @entity9164 and @entity4192 null genotypes were detected by the Gap-polymerase chain reaction method. RESULTS: A total of 42% of @entity1 appeared to lack @entity9164 enzyme activity due to the presence of an extended deletion ( @entity9164 0/0 genotype), compared with 18% in a control group (odds ratio [OR], 3.56; 95% confidence interval [CI], 1.35-9.37; P < 0.010). In addition, the prevalence of the @entity4192 null genotype in @entity1 was higher than that in the control group (42% to 14%, P  <  0.009). Also, it was shown that individuals with both null genotypes (-/-) had a 19.23-fold higher risk of developing the disease in comparison to @entity1 who showed both present genotypes (+/+). (P  =  0.007; 95%CI, 2.20-167.41). Besides, it was observed that at least one null genotype increases the risk of @entity1868 to 2.6 compared to the both present genotype (P-value  <  0.03, 95%CI, 1.05-6.82). CONCLUSION: To our knowledge, this is first significant correlation between risk of @entity2909 and null @entity9164 and @entity4192 genotypes among Iranian @entity1 . Our data support the involvement of @entity9164 and @entity4192 in @entity2909 liability, and especially its role as a genetic factor in the occurrence of this disease.

title: Impact of null genotypes of @entity4192 and XXXX with @entity2909 risk in Iranian population.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'people']

entities_list: @entity2909 :: ('MESH:D007889', 'Disease') :: ['uterine leiomyoma']

answer: @entity9164 :: (2944,Gene) :: ['GSTM1']


abstract: AIMS: To describe the birthweight specific rate of severe @entity1018 among babies born between 1 January 1984 and 31 December 1987 to mothers resident in a geographically defined area, to classify the causes of @entity1018 by time of origin, and to describe the associated @entity3481 and disabilities. METHODS: Cases were identified from a population register of @entity1 with early @entity73 , which uses multiple sources of ascertainment. Further clinical information was retrieved from hospital records and by asking ophthalmologists caring for the @entity1 . RESULTS: 166 (1.25/1000 live births) @entity1 with severe @entity1018 diagnosed by the age of 5 years were identified. The rate among babies born weighing less than 1500 g at birth was 26 times higher than the rate for babies between 2500 g and 3499 g. These very low birthweight babies contribute 17.5% of all severely visually impaired @entity1 . Almost two thirds of @entity1 with severe @entity1018 have a lesion of prenatal origin. Other @entity3481 are present in 69% of the @entity1 . @entity989 of @entity3465 accounted for 5.4% of all visually impaired @entity1 and seven of the 166 @entity1 met the criteria for perinatal @entity1763 . CONCLUSIONS: Although the contribution made by babies with a low birth weight to overall severe @entity1018 in the community is small, many of these @entity1 have additional impairments and probably place considerable demands on health and educational services and families. Reduction in the frequency of @entity227 problems in the preschool population as a whole is unlikely to occur until there are major advances in the understanding of the aetiology and prevention of eye conditions of genetic, prenatal, and developmental origin.

title: The contribution of low birth weight to severe XXXX in a geographically defined population.

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['vision loss']

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity3465 :: ('MESH:C536271', 'Disease') :: ['prematurity']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['childhood impairment']

entities_list: @entity3481 :: ('MESH:D015417', 'Disease') :: ['sensory and motor impairments', 'sensory or motor deficits']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['Retinopathy']

answer: @entity1018 :: (MESH:D054062,Disease) :: ['vision loss']


abstract: Vasodilator responses to @entity859 and @entity934 ( @entity1617 ) were studied in ring preparations of mesenteric resistance arteries of @entity35 -Kyoto @entity35 (WKY) and spontaneously @entity101 @entity35 (SHR). @entity859 (10(-7)-3 x 10(-4) M) caused relaxations in rings with endothelium. The relaxation was more pronounced in WKY than in SHR. Removal of the endothelium in WKY, but not in SHR, reduced the relaxation. In rings without endothelium, the relaxation was identical in the two strains. In WKY, the cyclooxygenase inhibitor @entity5728 attenuated the relaxation to @entity859 in rings with endothelium but not in rings without endothelium. With @entity5728 , the relaxation was identical in WKY arteries with and without endothelium. @entity1617 (10(-9)-10(-4) M) evoked endothelium-dependent relaxations in WKY. In contrast, in SHR the muscarinic agonist evoked contractions at higher concentrations (10(-6)-10(-4) M), whereas lower concentrations of @entity1617 caused relaxations similar to those observed in WKY. The contraction in SHR was completely inhibited by @entity5728 , and with @entity5728 the relaxation to @entity1617 was identical in WKY and SHR. Thus, @entity859 evokes endothelium-dependent (through release of cyclooxygenase product) and endothelium-independent relaxations and @entity1617 evokes endothelium-dependent relaxations in @entity35 mesenteric resistance arteries. In SHR, the endothelium-dependent responses to the agonists are altered owing to the changes in the endothelial cyclooxygenase pathway.

title: Changes in the endothelial cyclooxygenase pathway in resistance arteries of spontaneously XXXX @entity35 .

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity5728 :: ('MESH:D008469', 'Chemical') :: ['meclofenamic acid']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: OBJECTIVES: To estimate mortality risk associated with individual commonly prescribed antipsychotics. DESIGN: Five-year retrospective study. SETTING: Veterans national healthcare data. @entity1 : Predominantly male, aged 65 and older, with a diagnosis of @entity303 and no other indication for an antipsychotic. Subjects who received an antipsychotic were compared with randomly selected controls who did not. Exposed and control cohorts were matched according to their date of @entity303 diagnosis and time elapsed from diagnosis to the start of antipsychotic therapy. MEASUREMENTS: Mortality during incident antipsychotic use. RESULTS: Cohorts who were exposed to @entity1767 (n=2,217), @entity1037 (n=3,384), @entity1089 (n=4,277), or @entity1090 (n=8,249) had more comorbidities than their control cohorts. During the first 30 days, there was a significant increase in mortality in subgroups prescribed a daily dose of @entity1767 greater than 1 mg (hazard ratio (HR)=3.2, 95% confidence interval (CI)=2.2-4.5, P<.001), @entity1037 greater than 2.5 mg (HR=1.5, 95% CI=1.1-2.0, P=.01), or @entity1090 greater than 1 mg (HR=1.6, 95% CI=1.1-2.2, P=.01) adjusted for demographic characteristics, comorbidities, and medication history using Cox regression analyses. Greater mortality was not seen when a daily dose of @entity1089 greater than 50 mg (HR=1.2, 95% CI=0.7-1.8, P=.50) was prescribed, and there was no greater mortality associated with a dose less than 50 mg (HR=0.7, 95% CI=0.5-1.0, P=.03). No antipsychotic was associated with greater mortality after the first 30 days. CONCLUSION: Commonly prescribed doses of @entity1767 , @entity1037 , and @entity1090 , but not @entity1089 , were associated with a short-term increase in mortality. Further investigations are warranted to identify @entity1 characteristics and antipsychotic dosage regimens that are not associated with a greater risk of mortality in elderly @entity1 with @entity303 .

title: Are all commonly prescribed antipsychotics associated with greater mortality in elderly male veterans with XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

entities_list: @entity1037 :: ('MESH:C076029', 'Chemical') :: ['olanzapine']

entities_list: @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine']

entities_list: @entity1090 :: ('MESH:D018967', 'Chemical') :: ['risperidone']

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementia']


abstract: OBJECTIVE: across Africa the prevalence of postpartum @entity308 is a major health problem affecting mothers, their @entity1 and families. The purpose of this study was to explore the factors associated with @entity308 ( @entity308 ) among @entity1 living in a rural Ugandan district. DESIGN: descriptive correlation design. SETTING: Young- @entity1 's Clinic of a public hospital, providing postpartum care services to approximately 450 @entity1 and their babies per month in a rural district of Uganda. @entity1 : 202 postpartum @entity1 who have lived in the rural district both during pregnancy and postpartum period following birth of the current @entity1 of age  <=12 weeks. MEASUREMENTS: @entity308 were measured using the Edinburgh Postnatal Depression Scale (EPDS). @entity51 : @entity1 ' mean age and number of @entity1 were 24  4.33 years and 2.85  1.26 @entity1 , respectively. Majority of @entity1 were married (61%), delivered the current @entity1 by normal vaginal delivery (91%) at a health facility (86%) and experienced no complications (80%). The mean EPDS score for the sample was 9.5  0.18 and 43% of the @entity1 were found to have @entity308 (scores >= 10). Statistically significant relationships were found between @entity308 and factors such as number of female sexual partners the husband has (r=0. 28, p <=0.01); current problems in marriage (r=0.22, p <=0.01), @entity1 's parity (r=-0.24, p <=0.05), @entity1 's ability to breast feed (r=0.28, p <=0.05) and husband support during the postpartum period (r=0. 20, p <=0.05). CONCLUSION: male partners of postpartum @entity1 are a major source of factors associated with @entity308 in rural areas. IMPLICATION FOR PRACTICE: midwifery practitioners in rural settings should emphasise psychosocial assessment and male involvement in postpartum care to increase opportunities of identifying mothers at risk of @entity308 and implementation of interventions targeting @entity1 .

title: Factors associated with XXXX among postpartum mothers in a rural district in Uganda.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Child', 'women', 'children', 'participant', 'infants', 'PARTICIPANTS', 'infant', 'men']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['FINDINGS']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['postpartum depressive symptoms', 'PDS', 'depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: This paper attempts to summarize and statistically analyze 2,361 pediatric @entity1313 out of a total of 20,192 @entity1 @entity1313 from about 250 institutes in Japan during the period 1969-1978 in order to obtain an idea of their incidence and results of treatment. This report uses the classification and nomenclature adopted by UICC (Unio Internationalis Contra Cancrum) in 1965. Survival rate was computed as relative survival rate by the method reported by Cutler in 1964 [3]. Interestingly, @entity3438 (7.8%) are still frequent @entity5 in Japan. Astrocytoma (19.7%), @entity2946 (16.6%), @entity976 (12.5%), @entity3438 (7.8%) and @entity424 (6.6%) occurred in that order of frequency. Five-year survival rate of @entity2946 was 35.7% in subtotal and 55.3% in "total" removal. Radiotherapy was an effective therapeutic adjunct for the treatment of @entity2946 . The @entity3438 prognosis was good, with a 5-year survival rate of 42.4% without and 69.1% with radiation therapy, revealing radiotherapy as a statistically significant treatment. Radiotherapy, with or without shunt, is thus the treatment of choice. The survival rate of @entity1 with @entity976 was also high, with a 5-year survival of approximately 75% in partial and 76.3% in total removal. Most of the @entity976 were treated by partial @entity5 , with or without radiotherapy. @entity1 treated with radiotherapy survived a little longer than @entity1 without.

title: @entity1313 in childhood: statistical analysis of cases from the XXXX Registry of Japan.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients']

entities_list: @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymoma']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['removal of the tumor', 'tumors']

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['craniopharyngiomas', 'craniopharyngioma']

entities_list: @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma']

entities_list: @entity3438 :: ('MESH:D018237', 'Disease') :: ['germinoma', 'germinomas']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['Brain Tumor']


abstract: The survival of selected @entity880 bacteria (LAB) with in  vitro probiotic potential was studied during storage of cv. Halkidiki green olives previously subjected to inoculated Spanish-style fermentation. After fermentation olives were packed in @entity691 pouches, covered with freshly prepared brine (9%, w/v, @entity4202 ), acidified with 2    (w/v) @entity1792 and 1.5    (w/v) @entity620 , and stored at 4 and 20    C for 357 days. Four packing treatments were studied, namely olives previously fermented by (i) the indigenous microbiota (control); (ii) @entity4414 B281; (iii) @entity1336 B282; and (iv) a co-culture of both LAB strains. Microbiological analyses were performed on the olives in parallel with physicochemical changes (pH, titratable acidity, salt content, aw and colour) at the early (day 1), middle (day 197) and final stage (day 357) of storage, as well as sensory evaluation at the end of the storage. The survival of probiotic strains was confirmed by Pulsed Field Gel Electrophoresis (PFGE). LAB decreased throughout storage reaching a final population of ca. 3.5-4.0 log CFU/g and 4.5-5.0 log CFU/g at 4 and 20    C, respectively. The pH values ranged between 3.90 and 4.61 during storage depending on packaging condition. PFGE analysis revealed that @entity4414 B281 and @entity1336 B282 showed a high survival rate with a recovery of 100 and 96%, respectively, at 4    C, and less than 20% for both strains at 20    C. Finally, in the packing treatment with a co-culture of both strains, @entity4414 dominated over @entity1336 throughout storage at both temperatures.

title: Survival of potential probiotic XXXX bacteria on fermented green table olives during packaging in @entity691 pouches at 4 and 20    C.

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['polyethylene']

entities_list: @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citric acid']

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['ascorbic acid']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

entities_list: @entity1336 :: ('1590', 'Species') :: ['Lactobacillus plantarum', 'L.  plantarum']

entities_list: @entity4414 :: ('1589', 'Species') :: ['Lactobacillus pentosus', 'L.  pentosus']

answer: @entity880 :: (MESH:D019344,Chemical) :: ['lactic acid']


abstract: PURPOSE: To evaluate the efficacy of pterygoid dysjunction for the surgical management of @entity1348 ( @entity1348 ) @entity158 . MATERIALS: This study was composed of 10 @entity1 (20 joints), of whom 2 @entity1 had bilateral joint @entity158 . @entity1 were those who complained of @entity1348 with mild to moderate internal derangement and who have failed to respond to all methods of conservative management. Only @entity1 whose complaints of @entity158 were confined to the pterygoid muscles on palpation were considered for this study. Clinical examination included @entity158 and tenderness in relation to joint, muscles of mastication, @entity2720 . METHODS: Under general anesthesia, pterygomaxillary dysjunction was done bilaterally, the pterygoid plates were pushed backward, and the outcome was evaluated using computed tomography. RESULTS: Immediately after operation, most @entity1 were free from @entity158 , and the intensity of @entity158 was reduced in the rest of the @entity1 . There was progressive improvement of mouth opening, and clicking was reduced in most of the @entity1 in the late postoperative phase. Follow-up and regular counseling were done for 2 years. Clicking and mouth opening have considerable significance, but all @entity1 were free from @entity158 and were comfortable, except for some @entity1 who have simple complaints, which are irrelevant to this study. CONCLUSIONS: Although the total number of @entity1 was too small to arrive at any definitive conclusion, the encouraging results, especially the relief from @entity158 , show that this technique has a significant role in the treatment of painful @entity1348 , with mild to moderate internal derangement, and is devoid of other major complications.

title: Pterygoid dysjunction: new minimally invasive technique for the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and dysfunction', 'pain']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['movement of joint, and abnormal joint noises']

entities_list: @entity1348 :: ('MESH:D013706', 'Disease') :: ['TMJ pain and dysfunction', 'TMJ', 'TMJ dysfunction', 'temporomandibular joint']

answer: @entity1348 :: (MESH:D013706,Disease) :: ['painful temporomandibular joint dysfunction']


abstract: The @entity460 dependence of the vascular neuroeffector function has been studied in the portal vein of spontaneously @entity101 Okamoto @entity35 (SHR) and @entity35 -Kyoto @entity35 (WKY). The @entity1063 (NA) sensitivity of veins of both species, expressed in terms of ED50, was decreased to the same extent in relation to the reduction in @entity141 ion concentration below 2.5 mM. The responses to individual NA concentrations at subnormal @entity141 concentrations were better maintained, however, in portal veins from SHR than from WKY, indicating that the excitation contraction coupling mechanism is less dependent on external @entity141 concentrations in the portal vein from SHR than from WKY. In both strains of @entity35 the spontaneous myogenic activity of the vessel was depressed in low @entity141 concentrations to a greater extent than responses to nerve stimulation, which, in turn, were more reduced than the excitatory responses to exogenous NA or @entity934 ( @entity1617 ). Transmitter release (fractional overflow of 3H-NA/impulse) was less dependent on @entity141 concentrations than the contractile nerve stimulation response. The persistence of all responses in reduced @entity141 concentrations was significantly greater in the portal vein of SHR. It is concluded that the phasic, spontaneously active smooth muscle of the @entity35 portal vein is highly dependent on the external @entity460 concentration and that various induced responses persist to a varying degree in reduced @entity141 concentrations. It is suggested that this is due to interference with electromechanical coupling as well as myogenic spread of activation. Induced responses of the portal vein from SHR are, in general, less affected by decreased @entity141 concentrations than the WKY portal vein, indicating an altered vascular smooth muscle excitation-contraction coupling mechanism in spontaneous @entity101 . Possibly an increased efficiency of the coupling mechanism may contribute to augment vascular responses in the development of @entity101 and promote structural vascular changes.

title: Neuroeffector function of isolated portal vein from spontaneously @entity101 and @entity35 -kyoto @entity35 : dependence on external XXXX concentration.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: Cerebral arterioles of unanesthetized @entity95 equipped with chronically implanted cranial windows exhibited spontaneous rhythmic variation in vessel caliber characteristic of vasomotion. This variation was noted in all examined vessels. The vasomotion was independent of arterial blood pressure or respiration. The average frequency was 0.74 cycles/min and was independent of vessel size. The mean amplitude of the oscillations had a statistically significant inverse relationship to vessel diameter (r = 0.69). Vasodilation induced by arterial @entity2944 , topical @entity859 , or topical @entity934 had no significant effect on the frequency or amplitude of vasomotion. Anesthesia significantly reduced the frequency in arterioles of all sizes and markedly reduced amplitude in large arterioles. Topical verapamil resulted in a statistically significant reduction in frequency and in peak amplitude. Variations in vessel diameter occurred simultaneously in arterioles and their companion venules. We conclude that the cerebral microcirculation displays active vasomotion, which is significantly @entity308 by anesthesia or topical @entity1855 . The results also suggest that vasomotion is probably controlled by local factors.

title: Vasomotion in cerebral microcirculation of awake XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity2944 :: ('MESH:D006935', 'Disease') :: ['hypercapnia']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil']

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: PURPOSE: To evaluate biliary complications after irreversible electroporation (IRE) of @entity99 . MATERIALS AND METHODS: In 24 @entity1 (17 @entity1 ; mean age, 59.3  y), bile ducts were located within a 1.0-cm radius of the ablation zone at subacute follow-up (ie, 1-3 d) after percutaneous IRE of 53 @entity99 (primary @entity99 , n = 14). MR imaging, conducted with a hepatocyte-specific contrast agent before and after treatment, was examined for evidence of @entity1157 . Serum @entity648 and alkaline phosphatase levels measured at subacute and short-term follow-up (ie, 1-2 mo after IRE) were analyzed for evidence of @entity130 . Correlations between @entity1157 and characteristics of @entity1 , lesions, and ablation procedures were assessed by generalized linear models. RESULTS: Fifty-five bile ducts were located within 1.0  cm of an ablation defect. Locations relative to the ablation area were as follows: 33 were encased, 14 were abutting, and 8 were located within a radius of 0.1-1.0 cm of the ablation zone. Subacute follow-up MR images showed 15 @entity1157 (narrowing, n = 8; dilation, n = 7). At subacute follow-up, three @entity1 showed transient @entity854 ( @entity648 , 1.6-5.2  mg/dL). Short-term laboratory values were abnormal in one @entity1 (increase in alkaline phosphatase of 533  U/L vs baseline) as a result of local @entity5 recurrence. @entity1 age (continuous, P = .026; < 65 y vs >=  65 y, P = .001) was independently associated with post-IRE @entity1157 . CONCLUSIONS: Bile ducts adjacent to an IRE ablation area remain largely unaffected by this procedure.

title: XXXX after Irreversible Electroporation of Hepatic Malignancies: Evaluation of MR Imaging Findings and Laboratory Values.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'men']

entities_list: @entity1157 :: ('MESH:D001649', 'Disease') :: ['bile duct injury', 'bile duct injuries']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormalities of laboratory values']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumors', 'hepatic malignancies']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['biliary injury']

answer: @entity1157 :: (MESH:D001649,Disease) :: ['Bile Duct Injury']


abstract: The effect of common organic solvents on the activities of various @entity1 cytochromes P450 has been reported. However, very little is known about their influence on @entity11670 and @entity12327 enzymes. The purpose of this study was to investigate the effect of solvents on the kinetics of representative @entity11670 ( @entity752 hydroxylase) and @entity12327 ( @entity1311 hydroxylase) reactions in @entity1 liver microsomes. @entity1042 , @entity1068 , @entity3733 ( @entity3733 ), and @entity1626 were studied at increasing volumes (v/v). @entity1626 , @entity3733 , and @entity1068 were shown to increase the Km and decrease the intrinsic clearance (CLint) of @entity11670 -mediated @entity752 hydroxylation in a concentration-dependent manner. These solvents did not noticeably alter the Vmax at concentrations of < or =1% (v/v). Unlike the other solvents studied, the effect of @entity1042 (< or =0.5%, v/v) on @entity11670 kinetics was negligible. Both @entity3733 and @entity1068 increased the Km and decreased the CL(int) of @entity12327 -mediated @entity1311 hydroxylation in a concentration-dependent manner. @entity1626 had minimal influence on @entity12327 enzyme kinetics at concentrations of < or =1% (v/v). @entity1042 decreased the Km of @entity1311 at low concentrations followed by an increase at concentrations of > or =2% (v/v). This differential influence on Km resulted in an increased CLint at low concentrations followed by a decrease at high concentrations. The studied solvents had minimal influence on Vmax of @entity1311 . Collectively, @entity3733 and @entity1068 were not suitable for characterizing @entity11670 - and @entity12327 -mediated reactions because they showed concentration-dependent inhibition. @entity1042 and @entity1626 at concentrations of < or =0.5% and < or =1% (v/v) appeared to be suitable for the measurement of @entity11670 - and @entity12327 -mediated activities, respectively.

title: Effect of commonly used organic solvents on the kinetics of cytochrome P450 2B6- and 2C8-dependent activity in XXXX liver microsomes.

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol', 'Methanol']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity1626 :: ('MESH:C032159', 'Chemical') :: ['Acetonitrile', 'acetonitrile']

entities_list: @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide', 'DMSO']

entities_list: @entity752 :: ('MESH:D016642', 'Chemical') :: ['bupropion']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The Balb/Mo @entity19 carries a single copy of the germ line integrated @entity778 (M-MuL V) and shows a high @entity1778 frequency. According to the clinical @entity706 can be divided into two major categories. In one type the thymus appears to be the primary site for @entity706 development. The second type is dominated by the generalized enlargement of spleen and lymph nodes. @entity706 differ in the cell surface expression of @entity3512 , MCSA (designated operationally as the M-MuL V-determined cell surface antigen) and viral @entity8919 antigens. In addition, spleen and thymus of the same leukemic animal often differ antigenically. The karyotype of cells from enlarged organs is diploid or shows trisomy of chromosome 15. Lymphomas developing in Balb/Mo @entity19 are thus heterogeneous with regard to clinical manifestations, cell surface antigens and karyotype and, in this respect, do not differ from @entity706 arising after the inoculation of exogenous M-MuL V. Amplification of the M-MuL V genome in young Balb/Mo @entity19 is not accompanied by the appearance of MCSA on thymus cells. Still, 32% of @entity706 are MCSA positive. The results suggest that MCSA is related to a virus activated in a minority of Balb/Mo @entity19 during the late phase of leukemogenesis.

title: Antigenic and chromosomal changes in thymus and spleen of Balb/Mo XXXX during leukemogenesis.

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['Moloney leukemia virus']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'Individual lymphomas', 'manifestations lymphomas', 'lymphomas']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'mouse strain']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: OBJECTIVES: The effect of consumption of a @entity3505 -flour bread-based low-fibre diet (7.8 g/day fibre; 1.0 portion) or the same diet in which the @entity3505 bread was exchange for a bread based on oat bran with a high fibre content (31.9 g/day fibre; 1.0 portion) on the ileal excretion of @entity535 residues and crude protein was studied. DESIGN: The study was performed as a cross-over design. SETTING: The subjects were studied as outpatients except on the sampling days when all subjects were admitted to the research ward and stayed in a nearby @entity1 hotel overnight. SUBJECTS: Seven @entity1 and three @entity1 , all proctocolectomised for @entity31 , volunteered to participate in the study. One female subject was withdrawn from the study because of @entity32 . INTERVENTIONS: During each dietary period of 3 weeks, food and excreta were collected and analysed on days 3 and 17. RESULTS: No significant differences in excretion of crude protein or @entity1522 (free and bound) were found between the two sampling days. Intake as well as excretion of all analysed @entity1522 was higher during the high-fibre diet period, although the relative proportion of @entity1522 was comparable in the two diets and their corresponding ileal effluents. @entity2574 , @entity2228 , @entity1889 , @entity493 and @entity563 were found in considerably higher relative proportions in the effluents from the subjects when they consumed each of the two diets than their concentrations in the diets. The apparent digestibilities were significantly (P < 0.05) lower for all analysed @entity1522 during the high-fibre diet period. Aspartic acid (10.7%), @entity493 (9.9%) and @entity2228 (8.5%) showed a more pronounced decrease than the mean decrease in @entity535 digestibility (6.6%) when subjects consumed the high-fibre diet. CONCLUSION: Intake of the oat bran high-fibre diet resulted in significantly lower @entity535 and crude protein digestibility. The relative @entity535 proportions in the diets and their corresponding excretas were, however, comparable for the two diets.

title: Excretion of @entity535 residues from diets based on @entity3505 flour or oat bran in XXXX subjects with ileostomies.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation of the ileal stoma']

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

entities_list: @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['Aspartic acid']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: We present here two cases of @entity3557 ( @entity3557 ) in @entity1 affected by @entity4309 ( @entity4309 ). The first case is a 47-year-old @entity1 with typical @entity14 , reported with @entity43 at age 43, and @entity694 at age 45. The @entity1 underwent total thyroidectomy and central node dissection in 2007, at 47years old, with a histological diagnosis of @entity3557 (T1aN1a). Molecular genetics showed a germ-line mutation of the @entity6756 gene, @entity19801 ( @entity19802 ), with substitution of @entity8959 with a stop codon at position 620. This mutation has pathogenetic significance and was considered responsible for the various @entity5 of the @entity14 spectrum. In particular, in the same kindred, spanning 5 generations, there were 5 members with @entity14 , 4 with @entity1204 , 3 with gastric and 2 with @entity0 . The second case is a 34-year-old @entity1 with typical @entity14 with colonic resection for @entity694 at age 21. The @entity1 underwent total thyroidectomy with central and lateral node dissection in 2010, at age 34, with a histological diagnosis of @entity3557 with nodal metastases (pT4N1b). Molecular genetic analysis showed a germ-line mutation of the @entity4311 gene ( @entity6244 insertion at position 907). This mutation had pathogenetic significance and was considered responsible for @entity14 development. Two similar cases have been reported: a 39-year-old @entity1 , and a 44-year-old @entity1 , affected by @entity14 , with @entity2867 and @entity189 , respectively. We reviewed the @entity4309 literature on the history, genetics and expanding @entity5 spectrum of this condition.

title: @entity3557 ( XXXX ) in @entity4309 : Report of two cases and discussion on @entity4309 behaviour and genetics.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'PTC']

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'man', 'woman', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['endometrial and ovarian carcinoma']

entities_list: @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome', 'LS']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'tumours']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['undifferentiated thyroid carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['HNPCC', 'colorectal cancer', 'hereditary non-polyposis colorectal cancer (HNPCC) syndrome', 'HNPCC syndrome']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity2867 :: ('MESH:D065646', 'Disease') :: ['anaplastic thyroid carcinoma']

answer: @entity3557 :: (MESH:C536915,Disease) :: ['PTC']


abstract: BACKGROUND: The long-term ingestion of @entity167 diminishes @entity2339 reactivity in @entity167 -dependent @entity1 , potentially altering future relapse risk. Although sex differences in @entity2339 functioning are apparent in healthy controls, disruptions in this system have received little attention in @entity167 -dependent @entity1 . In this study, we assessed the basal secretory profile of @entity4545 ( @entity4545 ) and @entity701 , adrenocortical sensitivity in both the presence and absence of endogenous corticotropic pituitary activation, and feedback pituitary glucocorticoid sensitivity to @entity619 . METHODS: Seven @entity1 4- to 8-week abstinent @entity167 -only dependent subjects and 10 age-matched female healthy controls were studied. All subjects were between 30 and 50 years old, not taking oral contraceptives, and were studied during the early follicular phase of their menstrual cycle. Circulating concentrations of @entity4545 and @entity701 were measured in blood samples collected at frequent intervals from 2000 to 0800 hour. A submaximal dose of cosyntropin (0.01 microg/kg), a synthetic @entity4545 (1-24), was administered at 0800 hour to assess adrenocortical sensitivity. In a separate session, low-dose cosyntropin was also administered following high-dose @entity619 (8 mg intravenous) to assess adrenocortical sensitivity in the relative absence of endogenous @entity4545 . In addition, the @entity4545 response to @entity619 was measured to determine the pituitary glucocorticoid negative feedback. Sessions were 5 days apart, and blood draws were obtained every 5 to 10 minutes. RESULTS: Mean concentrations and pulsatile characteristics of @entity4545 and @entity701 over 12 hours were not statistically different between the 2 groups. Healthy controls had a somewhat higher (p < 0.08) net peak, but not net integrated, @entity701 response to cosyntropin relative to the @entity167 -dependent @entity1 . There were no significant group differences in either the @entity4545 or @entity701 response to @entity619 nor in the net @entity701 response to cosyntropin following @entity619 . CONCLUSION: Significant differences in pituitary-adrenal function were not apparent between @entity167 -dependent @entity1 and matched controls. Despite the small n, it appears that @entity167 -dependent @entity1 do not show the same disruptions in HPA activity as @entity167 -dependent @entity1 . These findings may have relevance for gender-specific treatment effectiveness.

title: Adrenocortical and pituitary glucocorticoid feedback in abstinent @entity167 -dependent XXXX .

entities_list: @entity4545 :: ('5443', 'Gene') :: ['ACTH', 'adrenocorticotropic hormone']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['HPA axis', 'hypothalamic-pituitary-adrenal (HPA) axis']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: @entity1 's @entity299 in Africa represent a public health problem that is difficult to cope with due to young population density, low socioeconomic status and lack of suitable technical platforms. This study aims to highlight the echocardiographic and therapeutic aspects of @entity13675 in @entity1 hospitalized at the pediatric department of the University Hospital Souro Sanou, Bobo-Dioulasso. We conducted a descriptive cross-sectional study over the period January 2013-December 2014 (24 months). It was based on a literature review of echocardiography reports performed on @entity1 under 15 years of age in the echocardiography laboratory of CHUSS and of medical records of their therapeutic follow-up. During the study period, 184 echocardiographic examinations were performed and allowed identification of 93 cases of @entity1 with @entity299 (50.50% of cases). Among them, 71% (66/93) of cases with @entity13675 were distinguished and 29% (27/93) of acquired @entity13675 . The most common @entity299 were: IVC (27.2%), IAC (10.6%), AVC (7.5%), F4T (9.1%), @entity2196 (6%), related forms ( 15%). Acquired @entity299 were dominated by @entity627 (48%), @entity384 (33.3%) and pericardial tamponade (18.5%). Surgery was recommended in 53.7% (50/93) of cases, of whom 86% (43/50) with @entity299 and 14% (7/50) with acquired @entity299 . 21% (9/43) of @entity1 with @entity299 underwent cardiac surgery. No acquired @entity299 requiring surgery was surgically treated. @entity13675 in @entity1 are frequent in Bobo-Dioulasso. Multidisciplinary strategies associated with resource optimization should improve the management of these @entity13675 .

title: [ @entity13675 in XXXX hospitalized at the University hospital Souro Sanou, Bobo-Dioulasso: echocardiographic and therapeutic aspects].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic valve diseases']

entities_list: @entity13675 :: ('MESH:C536187', 'Disease') :: ['Cardiopathies', 'congenital cardiopathies', 'cardiopathies']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['hypokinetic dilated cardiomyopathy']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart diseases', 'congenital heart diseases', 'heart disease']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: INTRODUCTION: @entity5 represent 3-10% of all @entity135 . These @entity5 occur predominantly in major salivary glands. The parotid gland is affected most often, ranging from 36.6% to 83%. The @entity5123 comprises 45-60% of all @entity5 . Several surgical approaches have been described to treat this @entity5 . Lesion of the facial nerve is one of the most serious complications that can occur after parotid gland surgery. OBJECTIVES: To determine possible predictive factors related to the occurrence of peripheral @entity3541 (PFP) after superficial parotidectomy in the surgical treatment of the @entity5123 of the parotid gland. METHODS: This was a primary, observational, case-control study performed through the revision of @entity1 ' charts and histopathological reports. Data was obtained from 1995 to 2014. The analyzed events were: @entity5 's length and depth; duration of the disease referred by the @entity1 (more than 1, 5 or 10 years); primary or secondary surgical approach. RESULTS: The analysis showed that @entity5 lengths equal or superior to 3.0cm were a risk factor of PFP with an odds ratio of 3.98 (p=0.0310). @entity5 depths equal or superior to 2.0cm were also a risk factor with an odds ratio of 9.5556 (p=0.0049). When the tested event was secondary surgery to recurrent @entity5 we have found an odds ratio of 6.7778 (p=0.0029). CONCLUSION: Tumors with 3.0cm or more in length and/or 2.0cm or more in depth have a significant higher risk of @entity2123 . Secondary surgery to recurrent @entity5 also has a much higher risk of evolving with @entity3541 after superficial parotidectomy.

title: XXXX after superficial parotidectomy: analysis of possible predictors of this complication.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Salivary gland tumors', 'Tumor', 'salivary gland tumors', 'tumors']

entities_list: @entity2123 :: ('MESH:D020220', 'Disease') :: ['facial nerve injury']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial paralysis', 'facial palsy']

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['pleomorphic adenomas', 'pleomorphic adenoma']

answer: @entity3541 :: (MESH:D005158,Disease) :: ['Facial paralysis']


abstract: CONTEXT: Symptoms of @entity308 and @entity65 ( @entity65 ) overlap substantially. Differentiating between dimensions of @entity308 may improve our understanding of the relationship between @entity308 and physical health. OBJECTIVE: To compare symptom dimensions of @entity308 as predictors of @entity65 and events among @entity1 with suspected @entity741 . DESIGN: Cohort study of @entity1 with suspected @entity741 who underwent evaluation at baseline for a history of cardiovascular-related problems, @entity308 using the Beck Depression Inventory, and @entity453 severity via coronary angiography. Principal components analyses (PCAs) of the Beck Depression Inventory items were conducted to examine differential @entity65 according to symptom dimensions of @entity308 . SETTING: The @entity1 's @entity63 Syndrome Evaluation (WISE), a multicenter study sponsored by the National Heart, Lung, and Blood Institute to assess cardiovascular function using state-of-the-art techniques in @entity1 referred for coronary angiography to evaluate @entity662 or suspected @entity741 . @entity1 : Five hundred fifty @entity1 (mean [SD] age, 58.4 [11.2] years) enrolled in the WISE study and followed up for a median of 5.8 years. MAIN OUTCOME MEASURES: Cardiovascular-related mortality and events ( @entity64 , @entity583 , and @entity712 ). RESULTS: When a 3-factor structure from PCA was used, somatic/affective (hazards ratio, 1.35; 95% confidence interval, 1.04-1.74) and appetitive (1.42; 1.21-1.68) but not cognitive/affective (0.89; 0.70-1.14) symptoms predicted @entity65 in adjusted multivariate Cox regression analysis. When a 2-factor structure from PCA was used, adjusted results indicated that somatic (hazards ratio, 1.63; 95% confidence interval, 1.28-2.08) but not cognitive/affective (0.87; 0.68-1.11) symptoms predicted worse prognosis. CONCLUSIONS: In a sample of @entity1 with suspected @entity741 , somatic but not cognitive/affective @entity308 were associated with an increased risk of cardiovascular-related mortality and events. These results support the need to research dimensions of @entity308 in @entity65 populations and have implications for understanding the connection between @entity308 and @entity65 .

title: Depressive symptom dimensions and XXXX among @entity1 with suspected @entity741 : A report from the National Heart, Lung, and Blood Institute-sponsored @entity1 's @entity63 Syndrome Evaluation.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'PARTICIPANTS']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depression']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular prognosis', 'CVD', 'cardiovascular-related death', 'cardiovascular disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular prognosis']


abstract: OBJECTIVE: To determine the natural history and visual prognosis of @entity1 with branch retinal @entity432 secondary to @entity2479 . METHODS: Cases were reviewed for seven @entity1 who exhibited @entity2479 and branch retinal @entity432 . The average age of the @entity1 was 27 years (age range, 14 to 19 years). RESULTS: Six @entity1 had systemic illnesses associated with their ocular findings. Four @entity1 were scratched by a cat or exposed to a cat with @entity11101 within 1 month of symptoms. Three of these @entity1 were tested and had positive @entity11102 titers. At presentation, five @entity1 complained of a @entity1019 , and two noted @entity227 . On examination, visual acuity was 20/25 or better in all but one eye. Five @entity1 had vitritis, which was bilateral in three. Four @entity1 exhibited @entity4 , which was bilateral in two. White intraretinal infiltrates were present in all @entity1 , and were bilateral in five. The six @entity1 who were examined within 1 week of symptoms had a white retinal infiltrate at the site of @entity432 . The retinal findings resolved in 2 to 6 weeks and did not recur. The final visual acuity was 20/20 OU in all @entity1 . CONCLUSIONS: Branch retinal @entity432 represent a complication of @entity2479 and idiopathic @entity4 . The @entity432 are probably caused by a focus of @entity2479 . This self-limited disorder has an excellent visual prognosis and may be related to @entity11102 .

title: Branch retinal XXXX in @entity2479 with @entity4 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['blurred vision']

entities_list: @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinitis', 'multifocal retinitis']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['optic nerve edema']

entities_list: @entity11102 :: ('MESH:D002372', 'Disease') :: ['cat-scratch disease']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['vascular occlusion', 'arterial occlusions', 'arterial occlusion']

answer: @entity432 :: (MESH:D001157,Disease) :: ['arterial occlusions']


abstract: OBJECTIVE: @entity571 ( @entity571 ) is a leading cause of @entity158 and @entity717 in middle-aged and older individuals. We undertook this study to determine predictors of the development of severe @entity571 , apart from age and overweight. METHODS: Joint replacement surgery due to severe hip or knee @entity571 was recorded over a 15-year period in the prospective Bruneck cohort study. Demographic characteristics and lifestyle and biochemical variables, including the level of soluble @entity4725 ( @entity4725 ), were assessed at the 1990 baseline visit and tested as predictors of joint replacement surgery. RESULTS: Between 1990 and 2005, hip or knee joint replacement due to @entity571 was performed in 60 subjects. @entity4725 level emerged as a highly significant predictor of the risk of joint replacement surgery. Intervention rates were 1.9, 4.2, and 10.1 per 1,000 @entity1 -years in the first, second, and third tertiles, of the @entity4725 level, respectively. In multivariable logistic regression analysis, the adjusted relative risk of joint replacement surgery in the highest versus the lowest tertile group of @entity4725 level was 3.9 (95% confidence interval 1.7-8.7) (P<0.001). Findings were robust in various sensitivity analyses and were consistent in subgroups. Addition of the @entity4725 level to a risk model already including age, sex, and body mass index resulted in significant @entity1650 (C statistic) and calibration and in more accurate risk classification of individual @entity1 . CONCLUSION: The level of soluble @entity4725 emerged as a strong and independent predictor of the risk of hip and knee joint replacement due to severe @entity571 . If our findings can be reproduced in other epidemiologic cohorts, they will assist in routine risk classification and will contribute to a better understanding of the etiology of @entity571 .

title: XXXX as a predictor of severe osteoarthritis of the hip and knee joints.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'person']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis']

entities_list: @entity1650 :: ('MESH:D001308', 'Disease') :: ['gains in model discrimination']

entities_list: @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule 1', 'VCAM-1']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['physical disability']

answer: @entity4725 :: (7412,Gene) :: ['Vascular cell adhesion molecule 1']


abstract: BACKGROUND: While @entity1887 @entity174 of the femoral head is most frequently seen in elderly @entity1 , this @entity174 has also been reported in some young individuals. QUESTIONS/PURPOSES: We asked whether a transtrochanteric rotational osteotomy for a @entity1887 @entity174 of the femoral head in young adults would (1) provide improvement in functional scores; and (2) lead to healing of the @entity174 . METHODS: We retrospectively reviewed five young @entity1 diagnosed with @entity1887 @entity174 of the femoral head. Nonoperative treatment was administered initially. Four of these @entity1 (average 22.3, years; range, 16-29 years) showed progressive collapse. An @entity717 was performed in these four @entity1 since the fractured area was located in the anterosuperior portion of the femoral head. All @entity1 were followed for a minimum of 2.0 years (average, 4.1 years; range, 2.0-9.1 years). RESULTS: The average preoperative Harris hip score was 71.6 points, which improved to an average of 97.2 at the latest followup. Radiographically, the @entity174 healed and no progression of collapse was observed in any of the four @entity1 . CONCLUSIONS: @entity717 seems a useful surgical option for treating young @entity1 with @entity1887 @entity174 of the femoral head if symptoms persist.

title: XXXX for a @entity1887 @entity174 of the femoral head in young adults.

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Anterior rotational osteotomy', 'anterior rotational osteotomy']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['subchondral insufficiency']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'fractured lesion']

answer: @entity717 :: (MESH:D009069,Disease) :: ['Transtrochanteric rotational osteotomy']


abstract: BACKGROUND: The effects of a balanced X; Autosome translocation [t(X;A)] on the fertility of carrier females led to the definition of the Xq13-->q27 region as critical for ovarian function and reproductive lifespan. We describe here a teenager with @entity2670 likely due to a balanced t(X;17)(q22;q25). CASE: The 16 year-old @entity1 presented with secondary @entity2588 . She exhibited height of 164 cm, slender habitus, and @entity4998 . METHODS: Hormonal determinations, @entity15533 - and RBG-banded karyotypes, fluorescence in situ hybridization, and @entity1 @entity342 receptor assay. RESULTS: FSH of 141 mIU/ml and LH of 46 mIU/ml); karyotype 46,X,t(X;17)(q22;q25)[30].ish der(X)t(X;1 7)(17qsubt el+); skewed inactivation of the normal X which was the maternal one as shown by the HUMARA assay. The maternal chromosomes were 46,XX; the father was unavailable. CONCLUSIONS: The @entity1 's (X;17) translocation likely accounts for her @entity2670 via an epigenetic downregulation of ovary expressed 17q25 genes relocated next to the Xq21 POF Critical Region 1 and related to ovarian development and function. Her otherwise inconspicuous phenotype agrees with the preferential inactivation of the normal X-chromosome that preserves the gene homeostasis in @entity1 with a balanced t(X;A). Finally, the normal maternal karyotype along with the HUMARA results and the sterility of males carrying a t(X;A) strongly suggests that this t(X;17) was a paternal de novo mutation.

title: A teenager with a t(X;17)(q22;q25) and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'patient']

entities_list: @entity4998 :: ('MESH:D012734', 'Disease') :: ['sexual development Tanner 2']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian failure']

entities_list: @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']

answer: @entity2670 :: (MESH:D010049,Disease) :: ['ovarian failure']