abstract: Administration of the @entity750 (1A) receptor agonist, @entity10097 , improves cardiovascular hemodynamics and tissue oxygenation in conscious @entity35 subjected to @entity1457 . This effect is mediated by sympathetic-dependent increases in venous tone. To determine the role of splanchnic nerves in this response, effects of @entity10097 (30 nmol/kg iv) were measured following fixed-arterial blood pressure @entity548 (i.e., maintenance of 50 mmHg arterial pressure for 25 min) in @entity35 subjected to bilateral @entity129 ( @entity129 ). Splanchnic denervation decreased baseline venous tone as measured by @entity551 ( @entity551 ) and accelerated the onset of @entity551 during @entity190 . Splanchnic denervation did not affect the immediate pressor effect of @entity10097 but did reverse the drug's lasting pressor effect, as well as its ability to increase @entity551 and improve @entity520 . Like @entity129 , adrenal demedullation (ADMX) lowered baseline @entity551 and accelerated the @entity551 response to blood withdrawal but also reduced the volume of blood withdrawal required to maintain arterial blood pressure at 50 mmHg. @entity10097 raised @entity551 early after administration in ADMX @entity35 , but the response did not persist throughout the posthemorrhage period. In a fixed-volume @entity548 model, @entity10097 continued to raise blood pressure in ADMX @entity35 . However, it produced only a transient and variable rise in @entity551 compared with sham-operated animals. The data indicate that @entity10097 increases venoconstriction and improves acid-base balance in @entity3485 @entity35 through activation of splanchnic nerves. This effect is due, in part, to activation of the adrenal medulla.

title: Sympathetic innervation of the splanchnic region mediates the beneficial hemodynamic effects of @entity10097 in XXXX .

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['SD', 'splanchnic nerve denervation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock', 'hemorrhage']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['hypovolemic shock']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemic']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive', 'mean circulatory filling pressure', 'MCFP', 'hypotension']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhagic shock']


abstract: AIM: With an increased use of endoscopic retrograde cholangiopancreatography (ERCP), risk factors for complication of cholangiopancreatography procedure has been focused in previous studies. We aimed to identify independent risk factors of post-ERCP @entity788 and @entity12828 by multivariate analysis, and develop a simple scoring system according to risk factors contributing to clinical prevention of post-ERCP @entity788 . METHODS: A retrospective single-center analysis was undertaken in 4,234 ERCP procedures between September 2007 and December 2012. @entity1 - and procedure-related risk factors for @entity7216 and @entity12828 were identified by univariate and multivariate regression analyses. A scoring system was developed based on the independent risk factors. RESULTS: @entity788 occurred after 226 ERCP procedures (5.3%) and @entity12828 after 774 procedures (18.3%). Female gender [odds ratio (OR), 1.449], first-time ERCP (OR, 1.745), no @entity1087 (OR, 1.917), difficult cannulation (OR, 3.317) and pancreatography (OR, 1.823) all proved to be significant predictive risk factors for @entity7216 . In addition to the similar factors, difficult cannulation (OR, 1.990) and pancreatography (OR, 2.009), age < 60 years (OR, 1.2), prior @entity6 (OR, 0.614), biliary duct stent placement (OR, 1.884) and nasobiliary drainage (OR, 1.613) were associated with development of @entity12828 . Prophylactic pancreatic duct stent (PS) might prevent the development of @entity7216 of @entity1 in very high-risk group (score >=  6). CONCLUSIONS: This study emphasizes the role of @entity1 - and procedure-related risk factors as the determining predictors for @entity7216 and @entity12828 . Technical procedures, for example, PS, are necessary to prevent @entity7216 in highest-risk @entity1 .

title: Risk factors for post-ERCP XXXX and @entity12828 : a retrospective single-center study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatitis', 'pancreatitis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity12828 :: ('MESH:D034321', 'Disease') :: ['hyperamylasemia']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']


abstract: UNASSIGNED: 4530 Background: Radiotherapy (RT) is considered the standard treatment for stages IIA/B @entity4797 . However, RT has been associated with an increased incidence of second @entity5 in long-term survivors. As @entity7730 ( @entity7730 ) is highly effective in @entity1442 and in recurrences after RT, we have developed a multicenter prospective protocol of treatment with @entity7730 in @entity1 (pts) with stages IIA/B @entity4797 . METHODS: We studied 71 consecutive pts with stages IIA and IIB @entity4797 , initially treated with @entity900 -based @entity7730 , from April 1994 to March 2003 in 26 centers. 34 of these pts were previously reported within a wider series of pts with stages II-IV @entity4797 (Ann Oncol 2001;12:487). @entity1 characteristics were: median age 38 (27-84) years; 18 pts had stage IIA and 53 had stage IIB; 11 of these pts had had a relapse of a previous stage I on surveillance; 8 pts had high BHCG levels. The treatment administered was: EP ( @entity2879 , @entity900 ) in 62 and @entity12962 ( @entity1732 , @entity2879 , @entity900 ) in 9 pts. The number of cycles per @entity1 was: 3 (9 pts), 4 (58), >4 (4). RESULTS: There were 59 (83%) complete responses and 12 (17%) partial responses with residual mass and normal markers. 2 pts underwent resection of residual masses. After a median follow-up of 46 months, 6 pts relapsed and one of them died. Progression-free survival and overall survival at 4 years were 91% (95%CI: 83%-98%) and 98% (95%CI: 89%-100%), respectively. @entity1503 was: Granulocytopenia G-IV:1 pts, G-III: 3, G-II: 6; @entity882 G-III:2, G-II:2; @entity417 G-III:1, G-II:1; @entity137 was: Nausea/Vomiting G-III:6, G-II:16, @entity3136 GIII: 1, G-II: 3, @entity294 G-III:1; @entity358 G-III:1; @entity2359 G-II:4; Skin rash G-II:1. No significant late @entity137 was observed. CONCLUSIONS: @entity7730 for stages IIA/B @entity4797 provides excellent results, is well tolerated and avoids the serious late morbidity associated with RT. Our results support the role of @entity7730 as an alternative to RT in the treatment of these pts. Comparison with RT focusing on long-term @entity137 would be of great interest. No significant financial relationships to disclose.

title: Chemotherapy as an alternative to radiotherapy in the treatment of stages IIA/B XXXX : A Spanish Germ Cell Cancer Group study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patient', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities', 'Extrahematological toxicity', 'toxicity']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['Stomatitis']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['Thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['Diarrhea']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Hematological toxicity']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['Pulmonary toxicity']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity7730 :: ('MESH:D064146', 'Disease') :: ['CT', 'chemotherapy']

entities_list: @entity4797 :: ('MESH:D018239', 'Disease') :: ['testicular seminoma', 'seminoma']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['Neurotoxicity']

answer: @entity4797 :: (MESH:D018239,Disease) :: ['testicular seminoma']


abstract: The @entity460 -dependent contraction of vertebrate skeletal muscle is thought to be primarily controlled through the interaction of the thick and thin filaments. Through measurement of the Donnan potential, we have shown that an electrical switching mechanism (sensitive to both anions and cations) is present in both A- and I-bands [1]. Here we show that this mechanism is not confined to the contractile apparatus and report for the first time the presence of M-line potentials. The Z-line responds to @entity141 ions in a similar manner to the A-band under the same solution conditions ( @entity1391 - @entity2865 and @entity8304 buffers), even though it has no reported @entity141 binding sites. Z-line potentials were not observed in @entity52187 buffer. The M-line has a markedly different response to any of the other subsarcomeric regions, however, and can only be detected in the @entity1391 - @entity2865 buffer. Preliminary observations of the M-line potential in @entity908 kinase-deficient @entity19 muscle ( @entity1391 - @entity2865 buffer) reveal significant differences in the @entity460 -induced transitions between two of the genotypes and demonstrate definitively that it is the M-line potential that is being recorded. From these results, it seems likely that the charge response of the Z-line and M-line is being mediated by @entity22405 in an anion-dependent manner. Our evidence comes from several observations. First, the similarity between the response of the Z-line potentials to the A-band potentials, where @entity22405 is the only link between these structures and second, the differential observation of M-line and Z-line potentials in a range of buffers containing different anion(s). Both Z-line and M-line potentials were seen in @entity1391 - @entity2865 buffer, but only the Z-line potentials could be detected in @entity2865 -only ( @entity8304 ) buffer and neither was observed in the acetate buffer. The latter observations can be attributed to two sources. The first is the effect of @entity598 buffer on the conformation of myosin [2]; the second is the absence of binding of the M-line protein, myomesin, to @entity22405 in the absence of @entity1391 ions [3].

title: Ion-dependence of Z-line and M-line response to XXXX in striated muscle fibres in rigor.

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate']

entities_list: @entity8304 :: ('MESH:C029899', 'Chemical') :: ['imidazole']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity52187 :: ('CHEBI:66869', 'Chemical') :: ['tris-acetate']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: OBJECTIVE: To evaluate the efficacy of pulsed high-dose @entity288 combined with orally administered low-dose @entity1499 therapy in @entity1 with severe @entity2631 ( @entity2631 ). DESIGN: A prospective, nonrandomized, open pilot study. SETTING: Dermatology department at a university hospital in Bochum, Germany. @entity1 Fifteen @entity1 with histologically confirmed severe @entity2631 . Interventions Oral @entity1499 (15 mg/wk) combined with pulsed intravenous @entity1667 (1000 mg for 3 days monthly) for at least 6 months. MAIN OUTCOME MEASURES: Treatment outcome was evaluated by means of a clinical score, 20-MHz ultrasonography, and histopathologic analysis. Safety assessment included the monitoring of adverse effects and clinical laboratory parameters. RESULTS: One @entity1 discontinued therapy. In most of the remaining 14 @entity1 , significant elimination of all signs of @entity66 ( @entity32 ) and remarkable softening of formerly affected @entity3808 skin that resulted in a decrease of the mean +/- SD clinical score from 10.9 +/- 5.3 at the beginning to 5.5 +/- 2.5 at the end of therapy was observed (P < .001). Clinical improvement was confirmed by histologic and ultrasonographic assessments. No serious adverse effects were noted. CONCLUSIONS: These data suggest that pulsed high-dose @entity288 combined with orally administered low-dose @entity1499 therapy is beneficial and safe in the treatment of @entity1 with @entity2631 . This treatment regimen should especially be considered for severe forms of @entity2631 in which conventional treatments have failed.

title: Pulsed high-dose XXXX combined with low-dose @entity1499 in severe @entity2631 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['active disease']

entities_list: @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic']

entities_list: @entity2631 :: ('MESH:D012594', 'Disease') :: ['localized scleroderma', 'LS']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity288 :: (MESH:D000305,Chemical) :: ['corticosteroids']


abstract: The activated nuclear factor-KappaB signaling pathway plays a critical role in inducing @entity130 . It has been reported that electroacupuncture could be an effective anti-inflammatory treatment. We aimed to explore the complex mechanism by which EA inhibits the activation of the @entity14185 signal pathway and ameliorate @entity130 in the short term; the effects of @entity61408 Binding Domain peptide for this purpose were compared. Focal cerebral I/R was induced by @entity2500 for 2   hrs. Total 380 male @entity35 are in the study. The neurobehavioral scores, @entity1188 volumes, and the levels of @entity3426 and @entity10957 were detected. @entity14185 p65, I k B a , @entity24764 , and @entity31001 were analyzed and the ability of @entity14185 binding DNA was investigated. The EA treatment and the NBD peptide treatment both reduced @entity1188 size, improved neurological scores, and regulated the levels of @entity3426 and @entity10957 . The treatment reduced the expression of @entity24764 and @entity31001 and altered the expression of @entity14185 p65 and I k B a in the cytoplasm and nucleus; the activity of @entity14185 was effectively reduced. We conclude that EA treatment might interfere with the process of @entity14185 nuclear translocation. And it also could suppress the activity of @entity14185 signaling pathway to ameliorate the @entity130 after focal @entity2806 /reperfusion.

title: Electroacupuncture Could Regulate the NF-kB Signaling Pathway to Ameliorate the Inflammatory Injury in Focal XXXX /Reperfusion Model @entity35 .

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusion']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['inflammatory injury']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['Cerebral Ischemia']


abstract: AIM: In @entity161 , @entity209 incidence is double that of the general population, with @entity1 having a higher incidence. Pharmacogenetically regulated @entity1501 may be related to this risk. DNA methylation and @entity209 within this group has not been previously studied. METHODS: @entity209 was evaluated with fasting laboratory measurements, and dietary and lifestyle assessments. Methylation analysis used a peripheral sample for the LINE-1 assay. DNA was also genotyped for @entity9769 @entity9770 . RESULTS: This analysis included 133 subjects. We found a significant relationship between LINE-1 methylation, and an interaction between @entity9769 and gender, controlling for serum @entity1501 (p = 0.008). Females with the 677TT genotype had the lowest methylation (56%) compared with the other groups (75%). CONCLUSION: TT genotype females had the lowest methylation, which may explain @entity209 gender differences in @entity161 . @entity1501 supplementation may be a suggested intervention within @entity161 ; however, additional work is required.

title: DNA methylation in @entity161 subjects: gender and XXXX 677C/T genotype differences.

entities_list: @entity1501 :: ('MESH:D005492', 'Chemical') :: ['Folate', 'folic acid', 'folate']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic syndrome', 'metabolic syndrome']

answer: @entity9769 :: (4524,Gene) :: ['MTHFR']


abstract: In order to assess the left ventricular (LV) @entity717 ( @entity717 ) in primary @entity101 (PH) @entity1 with a normal LV ejection fraction. Conventional echocardiography was performed in 61 healthy subjects and 64 PH @entity1 . The apical four-chamber views in these @entity1 were acquired by GE-Vivid7 or E9, then the peak radial strain in the systolic period and the strain rate in systole, in early and late diastolic periods, were measured. Segmental @entity717 and global @entity717 were assessed by using two-dimensional speckle tracking imaging (2D-STI). The peak radial strain rate in the early diastolic period in PH @entity1 was significantly lower than that in healthy subjects. The rotational degrees of the middle and base lateral, the apex and the middle septum walls in PH @entity1 were significantly different from those of the healthy subjects. The healthy subjects had prominent counter-clockwise @entity717 (0.29    2.86  ) and the PH @entity1 had prominent clockwise @entity717 (-2.13    2.93  ) in non-LV wall @entity1184 and (-2.43    2.66  ) in LV wall @entity1184 . The time delay between the LV lateral wall and the septum wall in PH @entity1 correlated to the peak @entity717 . We concluded that 2D-STI can assess the time delay between the LV lateral wall and the septum wall to the peak @entity717 and clockwise @entity717 in @entity1 with PH, and prove that PH @entity1 have a clockwise @entity717 . By this, we conclude that in PH @entity1 , the LV early systolic function have changed.

title: Left ventricular longitudinal rotation changes in primary @entity101 XXXX with normal left ventricular ejection fraction detected by two-dimensional speckle tracking imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['longitudinal rotation', 'LR']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: 1. Two groups of @entity3176 ( @entity3176 ) were fed on high- @entity165 diets which differed only with respect to the protein source. In one group casein was the only protein source, while the other group received only soya-bean protein. 2. Samples of blood, bile and liver biopsy material were collected at the commencement of the study and at 3-monthly intervals until termination 12 months later. 3. At the end of the experimental period all the animals (n 19) had high plasma @entity165 levels and had developed @entity2118 , the compositions and weights of which were not related to the protein source or to plasma @entity165 levels. Gallstone weight was related to the presence of acidic and sulphated mucins in @entity1085 . We were also unable to confirm the hypocholesterolaemic effect of soya-bean protein which has been demonstrated previously in @entity2608 and hamsters. Bile composition and plasma lipids did not differ significantly between the casein-fed and soya-bean fed animals. Lithogenic index was below 1 for both groups and did not differ significantly between the two groups. 4. No significant difference was found in the severity of @entity2963 between the casein-fed and the soya-bean-fed animals.

title: A comparison of the effects of soya-bean protein and casein on bile composition, @entity2963 and serum lipoprotein lipids in the XXXX ( @entity3176 ).

entities_list: @entity2608 :: ('9544', 'Species') :: ['rhesus monkeys']

entities_list: @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder mucosa']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigment gallstones']

entities_list: @entity3176 :: ('9534', 'Species') :: ['Cercopithecus aethiops', 'vervet monkeys']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity3176 :: (9534,Species) :: ['vervet monkey']


abstract: Twelve anesthetized @entity95 received endotoxin (175 +/- 38 micrograms/kg i.v., mean +/- SD) to evaluate the temporal sequence of alterations in left ventricular (LV) function. LV volume was calculated from LV minor- and long-axis diameters, and wall thickness was measured with sonomicrometers. @entity551 , @entity520 , and @entity519 were immediately corrected to eliminate these causes of @entity296 . @entity5988 developed early (1.2 +/- 0.5 h) with a significant (21 +/- 23%) increase in end-diastolic volume measured at a LV end-diastolic pressure of 5 +/- 6 mmHg. The LV stiffness did not change, and the @entity5988 did not progressively worsen. Significant systolic @entity308 developed later (2.8 +/- 1.0 h) with a 32 +/- 22% increase in end-systolic volume measured at a LV end-systolic pressure of 69 +/- 9 mmHg. The late preterminal phase (4.1 +/- 0.8 h) was characterized by a progressive increase in end-systolic volume (73 +/- 41% above control) and a significant (53 +/- 34%) increase in tau, the time constant of LV pressure fall. @entity854 ( @entity5988 and increased tau) were not attributable to depressed contractility or altered hemodynamics. We conclude that endotoxin impairs systolic and diastolic LV function with distinct differences in time course. This suggests that contractility, relaxation, and passive LV properties are impaired by different endotoxin-mediated pathways and/or have different sensitivities to endotoxin.

title: Temporal sequence of endotoxin-induced systolic and diastolic XXXX in @entity95 .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial depression']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity5988 :: ('MESH:C565277', 'Disease') :: ['LV dilation']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['Diastolic abnormalities']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotension']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial depression']


abstract: Chronic @entity205 (CsA) nephrotoxicity is characterized by tubulointerstitial @entity82 . @entity3131 ( @entity15795 ) is a novel antifibrotic compound that was shown to prevent and even reverse @entity82 . The mechanism of action of @entity15795 is unclear but involves inhibition of transforming growth factor-beta (TGF-beta). Salt-depleted @entity35 were administered CsA, CsA + @entity15795 , vehicle (VH) or VH + @entity15795 and sacrificed at 28days. Physiologic and histologic changes were studied in addition to @entity1810 , @entity2630 ( @entity2630 ) and @entity11188 mRNA expressions by Northern blot. @entity1810 immunohistochemistry was also performed. Treatment with @entity15795 ameliorated CsA-induced @entity82 by about 50% (p < 0.05). CsA-induced decrease in @entity1011 clearance improved with @entity15795 but the difference was not significant. @entity1810 , @entity2630 and @entity11188 mRNA expressions increased with CsA (p < 0.05 vs. VH) but strikingly improved with @entity15795 treatment (p < 0.05 vs. CsA), which brought the levels down to VH levels. @entity15795 treatment also decreased @entity1810 protein expression by 80%. These results demonstrate that @entity15795 can @entity8 in this model. @entity15795 was associated with a decrease in @entity1810 expression, which, in turn, was associated with a decrease in matrix deposition. These experiments suggest that @entity15795 can be clinically useful for preventing chronic CsA nephrotoxicity and may prove to be helpful in other progressive @entity8 .

title: @entity3131 treatment decreases transforming growth factor-beta1 and matrix proteins and ameliorates XXXX in chronic @entity205 nephrotoxicity.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['attenuate renal fibrosis', 'renal diseases']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity2630 :: ('24617(Tax:10116)', 'Gene') :: ['PAI-1', 'plasminogen activator inhibitor-1']

entities_list: @entity3131 :: ('MESH:C093844', 'Chemical') :: ['Pirfenidone']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity82 :: (MESH:D005355,Disease) :: ['fibrosis']


abstract: OBJECTIVE: To determine the association of social class with prevalence of coronary risk factors and @entity453 ( @entity453 ). DESIGN AND SETTING: Total community cross sectional survey of 20 randomly selected streets in the city of Moradabad. SUBJECTS AND METHODS: 1806 urban (904 @entity1 and 902 @entity1 ) randomly selected subjects aged 25-64 years. The survey methods were physician and dietitian administered questionnaire, physical examination and electrocardiography. All subjects were divided into social classes 1-5 based on attributes of education, occupation, per capita income, housing condition and consumer durables and other family assets. RESULTS: Social classes 1, 2 and 3 were mainly high and middle socioeconomic groups and 3 and 4 low income groups. The prevalence of @entity453 and coronary risk factors @entity1007 , @entity101 , @entity6 and sedentary lifestyle were significantly higher among social classes 1, 2 and 3 in both sexes compared to lower social classes. Mean serum @entity165 , @entity1674 , low density lipoprotein @entity165 and blood pressure were significantly associated with higher and middle social classes. Smoking was significantly associated with lower social classes. Multivariate logistic regression analysis after adjustment of age revealed that social class was positively associated with @entity453 (odds ratio: @entity1 0.84, @entity1 0.86), @entity1007 ( @entity1 0.87, @entity1 0.85), @entity101 ( @entity1 0.91, @entity1 0.89), @entity6 ( @entity1 0.71, @entity1 0.68) and sedentary lifestyle ( @entity1 0.68, @entity1 0.66). Smoking was significantly associated with @entity453 in @entity1 . CONCLUSION: Social class 1, 2 and 3 in an urban population of India have a higher prevalence of @entity453 and coronary risk factors @entity1007 , @entity101 , @entity6 and sedentary lifestyle in both sexes.

title: Social class and XXXX in a urban population of North India in the Indian Lifestyle and Heart Study.

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: OBJECTIVES: We compared the frequency of @entity146 in very preterm and term @entity1 at 5 years of age. We hypothesized that @entity146 would be associated with @entity73 and environmental factors and that differences between the 2 groups would be reduced but persist after adjusting for cognitive performance and environmental factors. @entity1 AND METHODS: The Etude Epid  miologique sur les Petits Ages Gestationnels (EPIPAGE) study was a prospective population-based cohort study that included all births occurring between 22 and 32 weeks' gestation and a control group of @entity1 born at 39 to 40 weeks' gestation in 1997 in 9 French regions. Neonatal and obstetrics data were collected at birth. At 5 years of age, sociodemographic status and neurodevelopmental and cognitive development of the @entity1 , as well as maternal mental well-being, were assessed. The @entity146 of 1102 very preterm and 375 term singletons without @entity73 were studied by using the parent-completed Strengths and Difficulties Questionnaire. RESULTS: Parents of very preterm @entity1 reported significantly more @entity146 , with a twofold higher prevalence compared with term @entity1 for @entity2915 /inattention, emotional symptoms, and peer problems. @entity146 were associated with low cognitive performance, @entity245 , hospitalizations of the @entity1 , young maternal age, and poor maternal mental well-being. Very preterm @entity1 were still at higher risk of @entity146 compared with term @entity1 after adjustment for cognitive performance and all others factors. CONCLUSIONS: @entity146 were strongly related to @entity73 , but very preterm @entity1 were still at higher risk even after adjusting for cognitive performance. Early screening for @entity146 should be encouraged for all very preterm @entity1 , and maternal well-being should also be the focus of special attention.

title: XXXX and cognitive performance at 5 years of age after very preterm birth: the EPIPAGE Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'PATIENTS', 'infants', 'child']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral problems', 'Behavioral problems']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['major impairments', 'cognitive impairment']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental delay']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity']

answer: @entity146 :: (MESH:D001523,Disease) :: ['Behavioral problems']


abstract: OBJECTIVE: To describe the prevalence, awareness, and control of @entity101 in a Swedish population during the early 2000s to address implications for care and prevention. DESIGN: A cross-sectional population survey. SETTING: Primary health care in Skaraborg, a rural part of western Sweden. SUBJECTS: @entity1 (n =2816) in a population survey of a random sample of @entity1 and @entity1 between 30 and 75 years of age in the municipalities of Vara (81% participation rate) and Sk  vde (70%), in western Sweden during 2001-2005. MAIN OUTCOME MEASURES: Anthropometric measures, blood pressure, leisure-time physical activity, current smoking, fasting @entity413 , and @entity165 . @entity101 was defined as ongoing treatment for @entity101 , or three consecutive blood pressure readings >= 140 systolic and/or >= 90 mmHg diastolic. @entity101 was considered controlled when the blood pressure was <140/90 mm Hg (both). RESULTS: The prevalence of @entity101 was 20% in both @entity1 and @entity1 with a steep increase by age. Among @entity101 subjects, 33% were unaware, 36% aware but uncontrolled, and 31% aware and controlled, with no statistically significant differences between @entity1 and @entity1 . @entity1 with @entity6 had a higher awareness (87% vs. 64%, p <0.001), but the same control rate (56% vs. 44%, p =0.133), when compared with those without @entity6 . CONCLUSION: A large proportion of subjects with @entity101 are still unaware of their condition, or aware but not controlled. It is important to emphasize population-based prevention to reduce the prevalence of @entity101 , to perform screening to increase awareness, and to improve implementation of expert guidelines in clinical practice to improve control.

title: Prevalence, awareness, treatment, and control of XXXX : rule of thirds in the Skaraborg project.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'Participants', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension', 'hypertensive']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Algorithms to predict @entity63 tissue fate based on @entity64 MRI typically utilized data at a single time point. The goal of this study was to investigate the potential improvement in prediction accuracy when incorporating MRI diffusion data from multiple time points during acute phase to improve prediction accuracy. This study was carried out using MRI data from @entity35 subjected to permanent, 60-min and 30-min of @entity2500 ( @entity2500 ). The sensitivity and specificity of prediction accuracy were calculated. In the permanent @entity2500 group, prediction with multiple time-point diffusion data improved sensitivity and specificity compared with prediction using a single time point. In the 60-min @entity2500 group, multiple time-point analysis improved specificity but decreased sensitivity compared to the single time-point analysis. In the 30-min @entity2500 group, multiple time-point analysis showed no statistically significant improvement in specificity and sensitivity compared with the single time point analysis. This is because reperfusion transiently or permanently reversed the decline in ADC values, resulting in increased uncertainty and thus decreased prediction accuracy. Incorporating this a priori information could further improve prediction accuracy in the reperfusion group. These findings suggest that incorporating MRI data from multiple time points could improve prediction accuracy under certain @entity63 conditions.

title: Incorporating ADC temporal profiles to predict @entity63 tissue fate in XXXX .

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['acute stroke']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity64 :: (MESH:D020521,Disease) :: ['acute stroke']


abstract: AIMS: In vitro studies have suggested that fructo-oligosaccharides (FOS) and resistant starch (two fermentable non-digestible @entity3363 ) display different fermentation kinetics. This study investigated whether these substrates affect the metabolic activity and bacterial composition of the intestinal microflora differently depending on the caecocolonic segment involved. METHODS AND RESULTS: Eighteen @entity35 were fed a low-fibre diet (Basal) or the same diet containing raw @entity415 starch (RPS) (9%) or short-chain FOS (9%) for 14 days. Changes in wet-content weights, bacterial populations and metabolites were investigated in the caecum, proximal and distal colon and faeces. Both substrates exerted a prebiotic effect compared with the Basal diet. However, FOS increased @entity880 -producing bacteria (LAPB) throughout the caecocolon and in faeces, whereas the effect of RPS was limited to the caecum and proximal colon. As compared with RPS, FOS doubled the pool of caecal fermentation products, while the situation was just the opposite distally. This difference was mainly because of the anatomical distribution of @entity880 , which accumulated in the caecum with FOS and in the distal colon with RPS. Faeces reflected these impacts only partly, showing the prebiotic effect of FOS and the metabolite increase induced by RPS. CONCLUSIONS: This study demonstrates that FOS and RPS exert complementary caecocolonic effects. SIGNIFICANCE AND IMPACT OF THE STUDY: The RPS and FOS combined ingestion could be beneficial by providing health-promoting effects throughout the caecocolon.

title: Raw @entity415 starch and short-chain fructo-oligosaccharides affect the composition and metabolic activity of XXXX intestinal microbiota differently depending on the caecocolonic segment involved.

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid', 'lactate']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Monocytes function as crucial innate effectors in the pathogenesis of chronic @entity32 , including autoimmunity, as well as in the inflammatory response against @entity166 pathogens. @entity1 monocytes are heterogeneous and can be classified into three distinct subsets based on @entity5750 and @entity4071 expression. Although accumulating evidence suggests distinct functions of monocyte subsets in inflammatory conditions, their pathogenic roles in @entity792 remain unclear. Thus, we investigated the phenotypic and functional characteristics of monocytes derived from synovial fluid and peripheral blood in @entity309 @entity1 in order to explore the pathogenic roles of these cells. In @entity309 @entity1 , @entity5750 + @entity4071 +, but not @entity57732 +, monocytes are predominantly expanded in synovial fluid and, to a lesser degree, in peripheral blood. Expression of co-signaling molecules of the B7 family, specifically @entity7938 and @entity25032 , was markedly elevated on synovial monocytes, while peripheral monocytes of @entity309 and healthy controls did not express these molecules without stimulation. To explore how synovial monocytes might gain these unique properties in the inflammatory milieu of the synovial fluid, peripheral monocytes were exposed to various stimuli. @entity4071 expression on @entity5750 + monocytes was clearly induced by @entity2533 , although co-treatment with @entity1356 , @entity310 , or @entity650 did not result in any additive effects. In contrast, TLR stimulation with @entity558 or zymosan significantly downregulated @entity4071 expression such that the @entity5750 + @entity4071 + monocyte subset could not be identified. Furthermore, treatment of monocytes with IFN-y resulted in the induction of @entity7938 and HLA-DR expression even in the presence of @entity2533 . An in vitro assay clearly showed that synovial monocytes possess the unique capability to promote @entity1198 as well as Th17 responses of autologous peripheral @entity404 memory T cells. Our findings suggest that the cytokine milieu of the synovial fluid shapes the unique features of synovial monocytes as well as their cardinal role in shaping inflammatory T-cell responses in @entity309 .

title: Functional Phenotype of Synovial Monocytes Modulating Inflammatory T-Cell Responses in XXXX ( @entity309 ).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory diseases']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious']

answer: @entity309 :: (MESH:D001172,Disease) :: ['Rheumatoid Arthritis']


abstract: This systematic review aims to summarise published evidence that assessed the management of @entity210 in regard to the following: prescription of urate lowering therapy (ULT), monitoring of serum urate levels (sUA) and @entity208 dosing in @entity1 with @entity8 , lifestyle advice and acute management of @entity210 . Studies investigating the management of @entity210 in general practice (GP) were identified by searching PubMed and Scopus databases. To be eligible for inclusion, studies had to be focused on the GP setting alone. Studies were also excluded if they examined diagnosis without exploring management of @entity210 . Editorials and reviews were excluded. A total of nine studies were identified. Eight studies explored the proportion of @entity210 @entity1 currently on ULT. Six out of the eight studies revealed that ULT was prescribed in less than 50  % of @entity210 @entity1 . Four studies considered the monitoring of sUA levels in @entity210 @entity1 . The results were generally similar throughout studies indicating sub-optimal management. Only two studies examined the monitoring of sUA levels specifically in @entity1 who were prescribed ULT. The two studies showed 28 and 38  % of @entity1 on ULT had their sUA levels monitored. Two studies examined the dosing of @entity208 in @entity8 @entity1 and revealed that 74-78  % of @entity8 @entity1 had an appropriate @entity208 dose of less than 300  mg. This systematic review suggests that @entity210 is sub-optimally managed in general practice. However, more studies with a larger sample size focusing on active @entity1 are required to provide more definitive evidence.

title: Management of XXXX in general practice-a systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renally impaired', 'renal impairment']

entities_list: @entity208 :: ('MESH:D000493', 'Chemical') :: ['allopurinol']

answer: @entity210 :: (MESH:D006073,Disease) :: ['gout']


abstract: 1. The chemical changes during contractile activity were separated from recovery metabolism in the forearm flexor musculature in normal @entity1 subjects using 31P nuclear magnetic resonance (NMR) spectroscopy. Percutaneous, supramaximal twitch stimulation of the median and ulnar nerves was used in combination with temporary ischaemia of the forearm to characterize the summed @entity4430 activity. The recovery following restoration of blood flow provided a measure of oxidative @entity855 synthesis activity. These processes were measured based on the dynamics of @entity1734 (PCr) content. 2. Muscle @entity26 stores were depleted using ischaemia without stimulation as indicated by PCr breakdown after 250 +/- 33 s (mean +/- S.D.; n = 5), which provided a measure of the basal metabolic rate (0.008 +/- 0.002 mM s-1, n = 5). 3. The PCr breakdown rate during twitch stimulation of the @entity26 -depleted muscle was constant at 1 Hz at 0.15 +/- 0.03 mM PCr per second or per twitch (n = 8). A constant cost per twitch was found from 0.5 to 2 Hz stimulation (depletion of PCr per twitch = 0.15 mM per twitch). 4. No net anaerobic recovery of PCr was found during a 2 min post-stimulation ischaemia. 5. Upon restoration of blood flow, PCr recovery followed an exponential time course with a time constant of 63 +/- 14 s (n = 8). From these recovery rates, the capacity for oxidative phosphorylation was estimated to be 0.4 mM s-1. 6. This experimental approach defines a non-invasive and quantitative measure of @entity1 muscle @entity4430 rate and @entity855 synthetase rate.

title: Separate measures of XXXX utilization and recovery in @entity1 skeletal muscle.

entities_list: @entity1734 :: ('CHEBI:17287', 'Chemical') :: ['creatine phosphate']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

answer: @entity855 :: (MESH:D000255,Chemical) :: ['ATP']


abstract: Carriers of @entity2100 premutations were previously considered phenotypically normal but are now known to be at risk for @entity11157 ( @entity11157 ). This prompted us to investigate whether premutation carriers (PC) have an increased risk for other diseases. We approached 306 @entity1 out of 84 fra(X) families of whom 264 (86.3%) participated in this study. A medical history was taken of these @entity1 . Whenever possible, the anamnestic data were verified with medical records. We first evaluated the occurrence of diseases that are commonly associated with menopause in PC and compared this to that in @entity1 with either a normal @entity10308 gene or a full mutation. We found no statistically significant differences in the occurrence of diseases known to be associated with menopause, such as @entity65 and @entity170 . However, lower bone mineral density was observed only in PC. Subsequently, we compared the occurrence of other medical problems between the two groups by estimating relative risks. PC did not demonstrate other diseases more commonly compared to non-PC from the same families. These findings are important for the counseling of PC. Carriership of the premutation may affect the ovaries, but does not substantially increase the risk for additional medical problems. Once a PC does experience @entity11157 , she is at risk for early @entity172 deprivation, which may lead to a premature decrease in bone density, when not treated.

title: Female carriers of @entity2100 premutations have no increased risk for additional diseases other than XXXX .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity11157 :: ('MESH:D016649', 'Disease') :: ['POF', 'premature ovarian failure']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity11157 :: (MESH:D016649,Disease) :: ['premature ovarian failure']


abstract: The objective of this study was to evaluate the feasibility and possible response to pre-radiation chemotherapy given to @entity1 with central nervous system (CNS) relapse of @entity1893 ( @entity1893 ). Twenty-three consecutive adult @entity1 with systenic @entity1893 and first CNS relapse were evaluated by CSF cytology and neuroaxis MRI. Treatment was based on weekly high-dose @entity1499 ( @entity2033 - @entity1500 ) 3.5 g/m2 and weekly intra-CSF @entity2592 ( @entity2592 ). Oral @entity4174 100 mg/m2 days 2-15 was added to @entity1 whose bone marrow reserve could tolerate this drug. @entity1161 ( @entity1161 ) to the CNS was deferred in responding/stable CNS disease. All @entity1 with leptomeningeal seeding, but without parenchymal involvement responded to treatment prior to @entity1161 with 33% achieving a complete response (CR). Concomitant response of @entity262 was noted in 36% of the cases with 9% CR. Addition of @entity1161 to the CNS did not significantly change the overall rate of CR. @entity6220 was 5 months and for @entity262 2 months. All @entity1 with parenchymal involvement responded to therapy prior to @entity1161 with only 9% achieving CR, and the addition of @entity1161 in these cases increased the rate of CR to 24%. In this group, three of four @entity1 who had active @entity262 responded systemically. Progression free survival was 3 months for both CNS and @entity262 . The median survival of the whole group was 6 months; 1-year survival 32% and 2-year survival 15%. In conclusion, systemic @entity2033 - @entity1500 -based combination chemotherapy yields an initial response rate of 100% in the CNS and a 47% concomitant systemic response. A complete CNS response can be obtained prior to @entity1161 but this adds little to the overall CR rate. Durable responses are rare. Since both CNS and systemic relapses appear in tandem, future trials should evaluate alternative modalities in order to enhance drug delivery into the CNS.

title: Central nervous system relapse of @entity1893 : results of treatment based on high-dose XXXX combination chemotherapy.

entities_list: @entity6220 :: ('MESH:D020279', 'Disease') :: ['Progression free survival for CNS disease']

entities_list: @entity4174 :: ('MESH:D011344', 'Chemical') :: ['procarbazine']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['RT', 'Radiation therapy']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine', 'ARA-C']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', "systemic non-Hodgkin's lymphoma"]

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: BACKGROUND: Matrix-induced autologous chondrocyte implantation (MACI) is an established technique for the repair of knee @entity154 . While a number of factors may affect the clinical outcome, little is known about the influence of subchondral @entity79 at the time of surgery on @entity158 and graft outcomes after MACI. PURPOSE: To investigate the association between subchondral @entity236 within 3 months before MACI surgery on preoperative and postoperative reported @entity158 and symptoms as well as postoperative graft outcomes. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: This retrospective study was undertaken in 56 @entity1 undergoing MACI with clinical and radiological assessments before surgery and at 3, 12, 24, and 60 months after surgery. @entity1 were assessed using the @entity158 and Symptoms subscales of the @entity3331 and @entity571 Outcome Score (KOOS). High-resolution magnetic resonance imaging (MRI) was used to evaluate the severity of preoperative subchondral @entity236 , while graft infill and an MRI composite graft score were evaluated after surgery via the magnetic resonance observation of cartilage repair tissue (MOCART) scoring system. Linear regression utilizing generalized estimating equations was used to investigate the association between preoperative subchondral @entity236 scores and preoperative and postoperative KOOS subscores as well as postoperative MRI-based scores of graft repair. RESULTS: The degree of preoperative subchondral @entity236 was not significantly associated with postoperative outcomes, whereby there was no evidence of a difference between @entity4 subgroups over all time points for the KOOS- @entity158 subscore (P = .644), KOOS-Symptoms subscore (P = .475), or MRI composite score (P = .685) after adjustment for potential confounders of age, body mass index, defect size, and defect location. CONCLUSION: No association was demonstrated between the severity of preoperative subchondral @entity236 with postoperative @entity1 -reported knee @entity158 or symptoms or postoperative graft repair assessed via MRI.

title: Degree of preoperative XXXX is not associated with @entity158 and graft outcomes after matrix-induced autologous chondrocyte implantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['chondral defects']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis']

entities_list: @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee Injury']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone abnormalities']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow edema']

answer: @entity4 :: (MESH:D004487,Disease) :: ['subchondral bone edema']


abstract: Abstract Nowadays laparoscopy is used frequently not only in elective surgery but also in @entity1661 , including @entity697 . There are several techniques used to close the @entity2055 during laparoscopic appendectomy. The aim of the study was to present the results of minimally invasive appendectomies performed with the use of @entity702 clips. material and methods. @entity1 operated on laparoscopically for @entity697 with the application of @entity702 clips between October 2012 and December 2013 were included in the study. We reviewed retrospectively @entity1  data including: age, sex, duration of the surgical procedure and hospital stay, mortality, intraoperative and postoperative complication rates. Results. There were 93 @entity1 (mean age=33.8 years, SD=15.23) in the analyzed group, including 60 @entity1 (mean age=33.5 years, SD= 15.07) and 33 @entity1 (mean age=33.9 years SD=15.26). The aver-age duration of the surgical procedure was 66 min (SD= 33.15). The average length of hospital stay was 3.38 days (SD=1.62). No intraoperative complications were observed in the analyzed group. Post-operative complication rate was low (6 cases, 6.5%). No mortality was observed. Conclusions. Laparoscopic appendectomy with the application of @entity702 clips for closure of the @entity2055 is safe, associated with low complication rates and should be considered as a routine technique in everyday surgical practice.

title: Results of laparoscopic appendectomies performed with the use of @entity702 clips for closure of the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal emergencies']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity2055 :: ('MESH:D001259', 'Disease') :: ['appendicular stump']

answer: @entity2055 :: (MESH:D001259,Disease) :: ['appendicular stump']


abstract: BACKGROUND: @entity1311 and @entity1013 (5'-DFUR) have distinct mechanisms of action and @entity137 profiles. This study evaluated the antitumor activity and @entity137 of combination chemotherapy with these drugs in @entity1 with advanced/recurrent @entity356 (AGC). @entity1 AND METHODS: @entity1 with histologically confirmed AGC, which was either unresectable or metastatic, were included in this study. The treatment consisted of 80 mg/m   @entity1311 given i.v. on days 1, 8, and 15 every 4 weeks, and 533 mg/m   @entity1013 given orally on days 1-5 every week. RESULTS: One hundred and four @entity1 were evaluated for @entity137 and 93 @entity1 were evaluated for a therapeutic response. The overall response rate was 33.3% (1st line: 41.7%, 2nd line: 25.0%), including a complete remission in two @entity1 , a partial remission in 29, stable disease in 39, progressive disease in 17; the response was not evaluable in six @entity1 . The median overall survival was 287 days. Commonly observed grade 3/4 adverse events were @entity1431 (13.5%), @entity448 (3.8%), @entity1295 (3.8%) and @entity294 (2.9%). CONCLUSION: @entity1311 and @entity1013 combination chemotherapy is a well-tolerated and convenient treatment regimen that can be given on an outpatient basis with promising efficacy for AGC.

title: A phase II study of weekly @entity1311 and @entity1013 combination chemotherapy for advanced/recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel', 'Paclitaxel']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity1013 :: ('MESH:C025034', 'Chemical') :: ['doxifluridine']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: During @entity28 , @entity32 of @entity1 @entity1386 ( @entity1386 ) is associated with metabolic and vascular alterations. Endothelial cells from visceral @entity1386 (VAT-ECs) exhibit a proinflammatory and senescent phenotype and could alter adipocyte functions. We aimed to determine the contribution of VAT-ECs to adipocyte dysfunction related to @entity32 and to rescue these alterations by anti-inflammatory strategies. We developed an original three-dimensional setting allowing maintenance of unilocular adipocyte functions. Coculture experiments demonstrated that VAT-ECs provoked a decrease in the lipolytic activity, adipokine secretion, and insulin sensitivity of adipocytes from obese subjects, as well as an increased production of several inflammatory molecules. Interleukin (IL)-6 and @entity1356 were identified as potential actors in these adipocyte alterations. The inflammatory burst was not observed in cocultured cells from lean subjects. Interestingly, pericytes, in functional interactions with ECs, exhibited a proinflammatory phenotype with diminished @entity3658 ( @entity3658 ) secretion in @entity1386 from obese subjects. Using the anti-inflammatory @entity3658 , we corrected some deleterious effects of @entity1386 -ECs on adipocytes, improving lipolytic activity and insulin sensitivity and reducing the secretion of proinflammatory molecules. In conclusion, we identified a negative impact of VAT-ECs on adipocyte functions during @entity1 @entity28 . Therapeutic options targeting EC @entity32 could prevent adipocyte alterations that contribute to @entity28 comorbidities.

title: Endothelial cells from visceral adipose tissue disrupt adipocyte functions in a three-dimensional setting: partial rescue by XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['white adipose tissue', 'WAT']

answer: @entity3658 :: (284,Gene) :: ['angiopoietin-1']


abstract: BACKGROUND: @entity1 who undergo mastectomy and breast reconstruction are shown to express more @entity158 than those who undergo mastectomy alone. The authors evaluated @entity282 outcomes following breast reconstruction. METHODS: @entity1 undergoing primary implant-based (n = 1038) or flap-based (n = 837) reconstructions from 2004 to 2012 at the University of California, Los Angeles, were evaluated. @entity282 was measured using the visual analogue scale, total narcotic use, and number of @entity1 -controlled analgesia attempts. Narcotic dosage was standardized to @entity1286 equivalents per kilogram. The authors modeled postoperative narcotic use, @entity1 -controlled analgesia attempts, and visual analogue scale scores over time using spline graphs for comparison between the two reconstruction methods. RESULTS: Both total narcotic use and @entity1 -controlled analgesia attempts were higher in the implant-based group throughout the immediate postoperative period. Implant-based reconstruction @entity1 had significantly higher visual analogue scale scores (p < 0.0001) and total narcotic use (p < 0.0001) through postoperative day 3 compared with autologous tissue-based reconstruction @entity1 . When controlling for reconstruction method, bilateral procedures were more @entity158 (visual analogue scale score and @entity1 -controlled analgesia attempts, both p < 0.001). When controlling for laterality, unilateral implant-based and autologous reconstructions had comparable visual analogue scale scores (p = 0.38) and @entity1 -controlled analgesia attempts. However, unilateral implant-based procedures required more narcotic use than unilateral autologous tissue-based procedures (p = 0.0012). CONCLUSION: Although commonly perceived as a less distressing operation, implant-based breast reconstruction may be more @entity158 during the immediate postoperative hospitalization than abdominally based free tissue transfer. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.

title: Comparison of XXXX control in autologous abdominal free flap versus implant-based breast reconstructions.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Women', 'patient']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain', 'Postoperative pain']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful']

answer: @entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']


abstract: BACKGROUND: @entity4372 ( @entity4372 ) has been shown to modulate in vitro cell functions according to the state of cell activation; however, few studies have evaluated the effect of @entity4372 in vivo. @entity32 , a major feature of @entity1030 ( @entity1030 ), is associated with an activation of inflammatory and resident cells, which in turn makes them more prompt to respond to further stimuli. OBJECTIVE: To evaluate whether @entity4372 might modulate, also in vivo, the release of preformed mediators and intracellular chemokines from airway cells of @entity1030 @entity1 . METHODS: Sputum was induced by inhalation of either @entity4372 (4.5% w/v) or isotonic saline ( @entity2717 0.9% w/v) solution and processed by plug selection. We measured @entity11153 ( @entity11153 ), neutrophil elastase (NE), @entity687 and @entity2842 ( @entity2842 ) in sputum samples obtained by either @entity4372 or @entity2717 inhalation in 24 @entity1030 @entity1 . RESULTS: No significant difference in mediators measured in sputum samples obtained by the two different inductions was observed; also, there was no significant difference in sputum sample volumes, cell viability, total and differential cell counts. Repeatability between the two tests was high for @entity11153 , NE, macrophages, neutrophils and eosinophils, and satisfactory for @entity687 and @entity2842 . CONCLUSIONS: Hyperosmolarity does not affect the levels of the inflammatory mediators and chemokines examined or the cell counts measured in induced sputum obtained from @entity1030 @entity1 . This study does not support the hypothesis that @entity4372 can stimulate chemokine and mediator release from airway cells of @entity1030 @entity1 . Therefore, @entity4372 and @entity2717 can be interchangeably used to measure inflammatory mediators in the sputum supernatant of @entity1030 @entity1 .

title: Can hypertonic saline inhalation influence preformed chemokine and mediator release in induced sputum of XXXX @entity1 ? Comparison with isotonic saline.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Chronic airway inflammation']

entities_list: @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP']

entities_list: @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'monocyte chemoattractant protein-1']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

entities_list: @entity4372 :: ('MESH:D009122', 'Disease') :: ['Hypertonic saline', 'HS']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']


abstract: OBJECTIVES: To examine the association between blood pressure, smoking and body mass index (BMI) and cerebro- and @entity65 in a population of healthy elderly. DESIGN: Ten-year mortality follow-up of elderly @entity1 and @entity1 who participated in the Nord-Tr  ndelag Health Study 1984-86. SETTING: Nord-Tr  ndelag county, Norway. SUBJECTS: 3121 @entity1 and 3271 @entity1 aged 70 years and older, free from any diagnosed @entity731 or @entity6 at baseline. MAIN OUTCOME MEASURES: Relative risk of cerebro- and @entity65 and all-cause mortality according to blood pressure, smoking and BMI. RESULTS: There was a consistent, positive association between systolic and diastolic blood pressure and cerebro- and @entity65 . The association persisted after adjustment for potential confounding factors, and was strongest for cerebrovascular mortality; the adjusted relative risks for systolic blood pressure categories 160-179 mmHg and > or = 180 mmHg in @entity1 were 1.63 (95% confidence interval, CI 1.06-2.53) and 2.19 (95% CI 1.39-3.44) compared to blood pressure < 140 mmHg. In @entity1 , the corresponding relative risks were 1.54 (95% CI 0.93-2.56) and 2.12 (95% CI 1.29-3.50). For diastolic blood pressure the adjusted relative risks in categories 100-109 and > or = 110 mmHg in @entity1 were 1.88 (95% CI 1.19-2.95) and 3.06 (95% CI 1.79-5.21) compared to pressure <90 mmHg. The corresponding relative risks in @entity1 were 1.75 (95% CI 1.05-2.91) and 2.02 (95% CI 1.04-3.93). Current smoking increased @entity65 in both @entity1 and @entity1 , and among @entity1 , BMI was negatively associated with all-cause mortality. CONCLUSIONS: These findings add to the growing evidence that @entity101 is a major risk factor for mortality from @entity64 and @entity301 among the elderly and the very old.

title: Blood pressure, smoking and body mass in relation to mortality from XXXX and @entity301 in the elderly. A 10-year follow-up in Norway.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic diseases']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: HYPOTHESIS: Characteristics of @entity6177 can be used to predict successful outcome for @entity1212 ( @entity1212 ). METHODS: We performed a multicenter prospective study of @entity1 who had @entity1320 treated with @entity1212 and intravenous antibiotics. Multivariate regression analysis determined predictors of successful outcome. RESULTS: The study included 96 @entity1 (59% @entity1 ; mean +/- SD age, 48 +/- 17 years; mean +/- SD Acute Physiology and Chronic Health Evaluation II score, 7.4 +/- 4.9). @entity86 was present in 53% of @entity1 . Isolated microorganisms included Bacteroides species (17%), @entity526 (17%), Streptococcus species (14%), Enterococcus species (10%), and fungi (11%). Single @entity733 were present in 83% of @entity1 . Computed tomographic guidance was used for drainage in 80% of @entity1 , and ultrasound was used in 20%. The duration of @entity733 was less than 14 days in 64%. Complete resolution of the infection with a single treatment of @entity1212 was achieved in 67 @entity1 (70%), and with a second attempt in 12 (12%). Thirty-three @entity1 (34%) had @entity1212 for the resolution of @entity1320 prior to an elective, definitive procedure. Open drainage as a result of @entity1212 failure was required in 15 (16%) and was more likely in @entity1 with @entity375 (P<.001) or a pancreatic process (P =.02). @entity86 (P =.04) was an independent predictor of successful outcome. CONCLUSIONS: Percutaneous catheter drainage of @entity1320 was effective with a single treatment in 70% of @entity1 and increased to 82% with a second attempt. A successful outcome is most likely with @entity733 that are postoperative, not pancreatic, and not infected with @entity375 . Percutaneous catheter drainage is now a commonly used staging method for the resolution of @entity1320 prior to corrective operation.

title: Determinants for successful percutaneous image-guided drainage of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity1212 :: ('MESH:D055499', 'Disease') :: ['percutaneous catheter drainage', 'PCD']

entities_list: @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['abscesses', 'abscess drainage']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['Postoperative abscess']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal sepsis', 'intra-abdominal infections']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity6177 :: (MESH:D018784,Disease) :: ['intra-abdominal abscess']


abstract: BACKGROUND: It is well demonstrated that @entity28 is an independent risk factor for @entity65 . Recent studies have shown that @entity28 , insulin resistance and @entity731 are closely related phenomena in which low-grade inflammatory state and prothrombotic condition has pivotal roles. It has been shown that @entity2936 -soluble @entity2936 ligand (sCD40L) interactions might constitute an important mediator for @entity32 . The aim of the present study was to assess sCD40L in relation to hs-CRP and cardiovascular risk factors in relation to body mass index (BMI). MATERIALS AND METHODS: Serum sCD40L and hs-CRP concentrations were measured in 52 @entity28 @entity1 and 28 non- @entity28 subjects by ELISA. Insulin resistance was calculated by homeostasis model assessment-insulin resistance (HOMA-IR). We divided the @entity1 into three groups depending in their BMI levels (Group 1: BMI <25 kg/m(2), Group 2: BMI 30-34.9 kg/m(2), Group 3: BMI > or =35 kg/m(2)). RESULTS: We determined that the mean sCD40L of group 3 was significantly higher than group 1 and group 2 (p<0.05, p<0.05, respectively). However, there was no significant correlation between plasma sCD40L levels and BMI. Plasma levels of hs-CRP were higher in @entity28 group than the non- @entity28 group (p<0.001). The levels of sCD40L were not significantly different between the two groups. The mean hs-CRP levels increased gradually in accordance with groups of BMI, there was a strong correlation between hs-CRP levels and BMI (r=0.724, p<0.001). There was no significant correlation between sCD40L and hs-CRP levels in all @entity1 . CONCLUSIONS: It is still a subject for debate whether sCD40L levels are increased or not in @entity28 . However, the results of this study showed that sCD40L is substantially increased in @entity1 with severe @entity28 . In terms of causality, the relatively small sample size and cross-sectional design of this study are considered to be the limitation factors.

title: The levels of circulating markers of @entity731 and @entity32 in subjects with different degrees of body mass index: Soluble XXXX ligand and high-sensitivity C-reactive protein.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['vascular inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity2936 :: (958,Gene) :: ['CD40']


abstract: UNASSIGNED: Silicosis is a preventable @entity358 caused by the inhalation of respirable crystalline @entity3440 dust and can progress to @entity1576 and @entity204 . No effective specific treatment for @entity5636 is available; @entity1 are provided supportive care, and some @entity1 may be considered for lung transplantation. @entity5636 can develop or progress even after occupational exposure has ceased. The number of @entity204 from @entity5636 declined from 1,065 in 1968 to 165 in 2004. Hazardous occupational exposures to @entity3440 dust have long been known to occur in a variety of industrial operations, including mining, quarrying, sandblasting, rock drilling, road construction, pottery making, stone masonry, and tunneling operations. Recently, hazardous @entity3440 exposures have been newly documented during hydraulic fracturing of gas and oil wells and during fabrication and installation of engineered stone countertops. To describe temporal trends in @entity5636 mortality in the United States, CDC analyzed annual multiple cause-of- @entity204 data for 2001-2010 for decedents aged >= 15 years. During 2001-2010, a total of 1,437 decedents had @entity5636 coded as an underlying or contributing cause of @entity204 . The annual number of @entity5636 @entity204 declined from 164 ( @entity204 rate    = 0.74 per 1 million population) in 2001 to 101 (0.39 per 1 million) in 2010 (p = 0.002). Because of new operations and tasks placing workers at risk for @entity5636 , efforts to limit workplace exposure to crystalline @entity3440 need to be maintained.

title: Silicosis Mortality Trends and New Exposures to Respirable Crystalline XXXX - United States, 2001-2010.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5636 :: ('MESH:D012829', 'Disease') :: ['silicosis', 'Chronic silicosis']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['occupational lung disease']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity3440 :: (MESH:D012822,Chemical) :: ['Silica']


abstract: @entity43 is one of the major causes of @entity204 among @entity1 . The increasing knowledge about molecular events involved in the early stages of ovarian tumorigenesis may provide the basis for management in the future. In a series of 109 @entity1 with @entity189 in FIGO stages IA-IIC, a number of clinicopathologic prognostic factors (age, FIGO stage, histopathologic type, and @entity5 grade) were studied in relation to the biologic factors @entity876 , @entity588 , and @entity589 , which are important regulators of apoptosis. Immunohistochemical techniques were used. All the @entity1 received adjuvant chemotherapy after the primary surgery. Univariate analysis showed that expression of @entity876 was significantly associated with @entity5 grade (P = 0.014), probability of persistent disease (P = 0.016), and @entity5 -specific survival rate (P = 0.007). Positive @entity588 staining was associated with @entity5 subtype (P = 0.029) and a favorable @entity5 grade distribution (P = 0.034), but not with the survival status. The combined @entity876 - @entity588 expression was related to histopathologic subtype (P = 0.032), @entity5 grade (P = 0.011), persistent disease (P = 0.014), and risk of dying due to the disease (P = 0.039). The @entity589 status was not a prognostic factor, but the combined @entity876 - @entity589 expression showed an association with FIGO stage (P = 0.014), @entity5 grade (P = 0.034), persistent disease (P = 0.006), and risk of dying due to the disease (P = 0.039). The combined @entity588 - @entity589 expression was related to histopathologic subtype (P = 0.045) and @entity5 grade (P = 0.022). In a multivariate Cox analysis, @entity5 grade (P = 0.014), and @entity876 status (P = 0.020) were independent and significant prognostic factors with regard to the @entity5 -specific survival rate.

title: The prognostic importance of XXXX , @entity588 , and @entity589 in early @entity43 treated with adjuvant chemotherapy.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Epithelial ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'endometrioid tumor', 'cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['epithelial carcinomas']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: OBJECTIVE: To evaluate the association between @entity1593 and specific @entity308 and to identify potential common pathogenetic links, with particular regard to thyroid function and @entity792 . METHODS: Cases included 36 adult celiac @entity1 , 25 females and 11 males, aged 18-64 years. Controls comprised 144 healthy subjects matched by sex and age with no clinical evidence or family history of @entity1593 . Diagnosis of @entity1593 was made on the basis of clinical history and serological criteria. Psychiatric diagnoses were formulated using the International Composite Diagnostic Interview, according to DSM-IV criteria. Thyroid was evaluated by palpation, echography and measurement of serum-free thyroid hormones (FT4, FT3), thyroid-stimulating hormone (TSH) and antithyroid autoantibodies (anti-TPO). RESULTS: Compared to controls, a significantly higher number of celiac @entity1 met criteria for lifetime [15 (41.7%) versus 30 (29.8%), P < .01] and 6-month [7 (19.4%) versus 9 (6.2%), OR = 3.2, chi(2) = 5.2, P < .05] @entity308 ( @entity308 ) and lifetime [5 (13.9%) versus 3 (2.1%), P < .001] and 6-month [3 (8.1%) versus 2 (1.4%), P < .05] @entity4697 ( @entity4697 ). Anti-TPO prevalence was significantly higher in celiac @entity1 than in the control group (11/36 = 30.5% versus 14/144 = 9.7%, P < .001). A higher frequency of @entity4697 and @entity308 was found in celiac @entity1 with positive anti-TPO when compared to negative anti-TPO @entity1 (4/11 = 36.4% @entity4697 in TPO+ versus 1/25 = 4% @entity4697 in TPO-, P < .01; 9/11 = 81.8% @entity601 in TPO+ versus 6/25 = 9.5% @entity601 in TPO-, P < .01). CONCLUSION: @entity1 affected by @entity1593 tend to show a high prevalence of @entity4697 and @entity308 and association with subclinical @entity1374 appears to represent a significant risk factor for these @entity146 .

title: Association between XXXX , @entity308 and @entity1593 : a possible role of thyroid @entity792 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'anxiety and depressive disorders', 'major depressive disorder']

entities_list: @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease']

entities_list: @entity4697 :: ('MESH:D016584', 'Disease') :: ['PD', 'panic disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease']

answer: @entity4697 :: (MESH:D016584,Disease) :: ['panic disorder']


abstract: UNASSIGNED: The purpose of this study was to evaluate the oncological and functional outcomes in @entity1 who underwent supracricoid laryngectomies with a crico-hyoidopexy (SCL-CHP) or a crico-hyoido-epiglottopexy (SCL-CHEP) for the treatment of primary and reccurent @entity5 . A retrospective study was conducted on 152 consecutive @entity1 seen from January 1996 to December 2006. @entity1349 ( @entity1349 ) and disease-free survival (DFS) were analysed using the Kaplan-Meier method, and were compared according to the type of surgery and clinical stage of the @entity5 . The mean period before decannulation, nasogastric tube (NGT) removal and recovery of a normal diet and speech were evaluated, and statistical analyses were performed regarding the association with the type of surgery and arytenoidectomy. The median follow-up period was 49.9 months (range: 10-110 months). The 3- and 5-year @entity1349 were 87.5 and 83.5%, respectively, and 3- and 5-year DFS were 78.3 and 73.7%, respectively. For @entity1 with early stages @entity5 , the 5-year @entity1349 and DFS were 92.3 and 84.6% respectively, whereas for @entity1 with locally advanced stage @entity5 , the @entity1349 and DFS were 74.3 and 62.2%, respectively. Significant differences in @entity1349 and DFS for @entity1 who had early or locally advanced @entity5 were found (p = 0.0004 and p = 0.0032, respectively). The rate of overall local control was 92.1%, while the mean period until decannulation or NGT removal was 25.1 and 16.6 days, respectively. The mean period until NGT removal was significantly different according to the type of surgery (p = 0.0001) and whether arytenoidectomy was performed (p = 0.0001). The reliable oncological and functional results of SCL for early and locally advanced @entity5 are confirmed by our series of @entity1 .

title: Supracricoid laryngectomies: oncological and functional results for 152 XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'cancers', 'laryngeal cancers', 'tumours', 'tumour']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity2246 are rare and laboratories performing diagnostic tests in this field must participate in external quality assurance (EQA) schemes to demonstrate their competence and also to maintain sufficient experience with @entity1 material. EQA schemes for metabolite analyses are available (ERNDIM), but corresponding EQA schemes for enzyme analyses are nonexistent. In this paper we describe a pilot study on lysosomal enzyme testing by four centres in The Netherlands. Quantitative aspects of EQA were studied by interlaboratory comparison of activities of six lysosomal enzymes in a series of buffy coat samples. Interlaboratory variance was enormous. To reduce variance caused by methodological differences, @entity1 reported enzyme activities relative to mean normal values. Beta-D-Galactosidase activities compared well between the participating laboratories (average interlaboratory CV 13%), but for other enzymes large differences were observed, e.g. sphingomyelinase (average CV 38%). Diagnostic proficiency was tested with cultured fibroblasts. In 45 out of a total of 48 tests (12 cell lines, 4 @entity1 ) the correct diagnosis was accomplished on the basis of merely biochemical investigations, i.e. without clinical data of the @entity1 . In a survey using blood of a late-onset @entity13785 @entity1 , less conclusive results were obtained. A stable enzyme source was developed for easy distribution. Most lysosomal enzymes were stable upon lyophilization of leukocyte homogenates and during subsequent storage of the freeze-dried material at room temperature, in particular when cryolyoprotectant was added. Shipment of such lyophilized samples is simple and cheap and ideal for an EQA scheme. Our study shows that an EQA programme for enzymatic testing of @entity2315 is necessary to accomplish reliable diagnostic procedures for @entity2315 . We recommend that EQA for lysosomal enzymes be implemented through ERNDIM.

title: External quality assurance programme for enzymatic analysis of XXXX : a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity2315 :: ('MESH:D016464', 'Disease') :: ['lysosomal storage diseases']

entities_list: @entity13785 :: ('MESH:D006009', 'Disease') :: ['Pompe disease']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['Inborn errors of metabolism']

answer: @entity2315 :: (MESH:D016464,Disease) :: ['lysosomal storage diseases']


abstract: BACKGROUND: Electrical and mechanical dyssynchrony are often seen in @entity1 with @entity1002 . In @entity120 (PH), @entity67 predominates; however, the prevalence of electrical and/or mechanical dyssynchrony in these @entity1 is unknown. We examined the prevalence of electrical and mechanical dyssynchrony in pediatric PH @entity1 . METHODS: Medical records (including, functional status, electrocardiograms and echocardiograms) of pediatric PH @entity1 were reviewed. QRS duration z-scores were calculated to determine electrical dyssynchrony. Echo vector velocity imaging was used to calculate the mechanical @entity894 ( @entity894 ). RESULTS: Seventy-seven PH @entity1 ( @entity8577 [ @entity8577 ]: n = 26; @entity299 : n = 41; other: n = 10) were studied. Electrical dyssynchrony was seen in 84% (p < 0.01 vs historic controls), with a mean z-score of 4.3 (95% CI 3.5 to 5.1). There was no difference between those with @entity8577 , z = 3.6 (95% CI 2.5 to 4.6), and those without, z = 4.7 (95% CI 3.6 to 5.8). Mechanical dyssynchrony was seen in 76% of @entity1 (mean @entity894 = 66    47 vs 18    8 milliseconds in historic controls, p < 0.01) in both @entity8577 and non- @entity8577 @entity1 . Post-operative @entity299 @entity1 had the largest @entity894 . No correlation was found among electrical or mechanical dyssynchrony, hemodynamics or disease severity. CONCLUSIONS: Significant electrical and mechanical dyssynchrony is present in pediatric PH @entity1 , regardless of etiology. The overall effect of electrical and mechanical dyssynchrony on outcomes in this @entity1 population is still unknown. Select @entity1 may benefit from resynchronization therapy.

title: Electrical and mechanical dyssynchrony in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity894 :: ('MESH:C566784', 'Disease') :: ['dyssynchrony index', 'DI']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pediatric pulmonary hypertension']

entities_list: @entity8577 :: ('MESH:D065627', 'Disease') :: ['IPAH', 'idiopathic pulmonary arterial hypertension']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['right ventricular failure']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular failure']

answer: @entity120 :: (MESH:D006976,Disease) :: ['pediatric pulmonary hypertension']


abstract: PURPOSE: To examine early corneal epithelial changes in recurrent @entity1034 . MATERIAL AND METHODS: Three @entity1 presenting early (< or =18, < or =24 and < or =29 hours) after the onset of symptoms were examined by means of non-contact in vivo photomicrography. RESULTS: Case 1 (< or =18 hours) showed about 60 rounded or irregularly shaped and partly confluent intraepithelial lesions. In case 2 (< or =24 hours) similar lesions and a @entity2343 with a broken pattern were present. Case 3 (< or =29 hours) showed four separate lesions and a large dendrite. Some lesions appeared as dark protrusions in the @entity941 stained tear film, others stained green; of these, some additionally showed @entity941 diffusion into the surroundings. The smallest discernible entities were abnormal cells of about 10 microm in diameter, present both within the lesions and scattered elsewhere, and clearly swollen cells of about 15 microm of diameter. CONCLUSIONS: The distribution of the precursors shows the multifocal origin of HSV dendritic figures. The dark protruding lesions with abnormal cells covered by intact overlying cell layer(s) seem to be the earliest HSV epithelial changes so far captured in the living @entity1 @entity267 . The protrusions are probably the result of cell swelling representing the incipient stage of HSV cytopathic effect, and the subsurface location of the abnormal cells suggests that the initial virus target are the deeper epithelial layers. The morphological features of the remaining lesions are consistent with successive stages of cell degeneration, i.e. cell swelling leading to surface disruptions, burst of the cells, and cell desquamation resulting in surface ulcerations. The contemporaneous presence of all these stages is typical of recurrent @entity2025 .

title: Early epithelial changes in recurrent @entity1034 : a non-contact photomicrographic study in vivo in the @entity1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1034 :: ('MESH:D016849', 'Disease') :: ['herpes simplex virus (HSV) type 1 keratitis']

entities_list: @entity2343 :: ('MESH:D007635', 'Disease') :: ['dendritic figure']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity2025 :: ('MESH:D020031', 'Disease') :: ['HSV type 1 infections']

answer: @entity267 :: (MESH:D065306,Disease) :: ['cornea']


abstract: BACKGROUND: The Ontario @entity1503 Project is a pilot study of @entity1503 ( @entity1503 ) for @entity14 screening conducted among age-eligible volunteers (50 to 75 years) in 12 of 37 public health regions in Ontario. METHODS: Volunteers responded to invitations from primary care practitioners (PCPs) in six regions, and from public health programs in the remaining regions. @entity1503 collection kits were distributed from routine laboratory specimen collection sites, to which completed kits were returned. Results were sent to PCPs in all 12 regions, with copies sent to the study office at Cancer Care Ontario (Toronto, Ontario). Follow-up of positive results was at the discretion of the PCPs. The study files contained the unique Ontario Health Insurance Numbers, the date of the analyses, the number of satisfactory slides and the results for each slide. The Ontario Health Insurance Numbers were encrypted for each @entity1 , and along with the study file, were linked to medical billing claims, hospital records and aggregate demographic data. RESULTS: Among @entity1 with positive results ( @entity1 3.5% and @entity1 2.2%), the median time from date of @entity1503 analysis to date of colonoscopy was 121 days among @entity1 and 202 days among @entity1 . At the end of follow-up, after positive @entity1503 (six to 17 months), 73% of @entity1 and 56% of @entity1 had proceeded to colonoscopy. CONCLUSION: Although colonoscopy appeared to be acceptable to the majority of @entity1 with positive @entity1503 , accessibility problems was the likely explanation for lengthy intervals between the date of positive @entity1503 and its performance. Differences between the experiences of @entity1 and @entity1 require further investigation.

title: Endoscopic follow-up of positive XXXX in the Ontario @entity1503 Project.

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['fecal occult blood testing', 'FOBT']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'participant', 'men']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity1503 :: (MESH:D006402,Disease) :: ['fecal occult blood testing']


abstract: OBJECTIVE: Authors evaluate a case of an extremely large @entity2909 , its symptomatology, diagnosis and surgical treatment. They present the possible @entity3816 and emphasize the necessity of the interdisciplinary approach. METHODS: The set of @entity1 consists of 21 @entity1 with @entity2909 of various localizations. All @entity1 were operated by means of conventional operation. The material was sent for classical bioptic examination with the use of immuno-histochemical analysis. RESULTS: Unlike found in literature, the most common appearance of @entity2909 in our set of @entity1 was on small bowel, namely 10 of 21 @entity1 had @entity5 in this localization. Furthermore there were three @entity5 of gynecological origin. Two of them had @entity697 ( @entity697 ) while in these cases, ileus was a reason for urgent operations. In all three gynecological cases it was difficult to diagnose preoperatively the origin of @entity5 . In one @entity1 , the preparation led to partial iatrogenic lesion of left ureter which was subsequently treated with primary suture. The authors describe zero mortality. CONCLUSION: Despite the relatively simple diagnosis of @entity2909 , in some cases of extreme size of the @entity5 combined with its localization in the small pelvis makes it difficult to distinguish it from other @entity361 . In order eliminate the @entity3816 it is possible to introduce a urethral catheter and to set up a multidisciplinary operation team to achieve combined experience (Fig. 5, Ref. 14).

title: Ileus, pregnancy or @entity2909 ? A case of a large intraabdominal XXXX .

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute abdominal disease', 'AAD']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors']

entities_list: @entity2909 :: ('MESH:D007889', 'Disease') :: ['leiomyomas', 'leiomyoma']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['peroperative complications']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: Sixty @entity1 with primary @entity96 (PHC) were treated with transcatheter hepatic artery infusion chemotherapy (TAI) and embolization (TAE) from June 1988 to December 1989. There were 54 males and 6 females. Their age ranged from 22 to 72 years with an average of 52. Course of disease ranged from 1/2 to 12 months. In these 60 cases, 31 had Stage II and 29 @entity5 . Using Seldinger's method per femoral artery, conventional hepatic angiography was performed. Afterwards, @entity632 or @entity900 infusion was carried out, followed by chemoembolization therapy of @entity5 vessels using mixture of ethiodized oil or @entity7549 and @entity1138 . Finally, gelatin sponge block was used for proximal @entity1416 . After the treatment procedure, @entity490 was relieved, @entity5 reduced in size, @entity160 , r-GT, AKP and LDH declined to various degrees and the survival time was prolonged. The 3-, 6- and 12-month survival rates were 93.3% (56/60), 67.3% (37/49) and 33.3% (9/27), respectively. It is indicated that TAI and TAE, being safe and effective, is the treatment of choice for @entity1 with unresectable PHC.

title: [Transcatheter hepatic artery infusion chemotherapy and embolization for 60 XXXX with primary @entity96 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity7549 :: ('MESH:D007481', 'Chemical') :: ['iophendylate']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatic carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Stage III lesions']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Frailty is highly prevalent in older @entity1 , but its association with cognitive function is poorly understood. The aim of this study was to examine the association between cognitive function and frailty in community-dwelling older adults. METHODS: Data were from the 2008 Living Profiles of Older @entity1 Survey, comprising 10,388 nationally representative sample aged 65 years and older living in the community in South Korea. Frailty criteria included unintentional weight loss, exhaustion, @entity425 , low physical activity, and slow walking speed. Cognitive function was assessed using the Korean version of the Mini-Mental State Examination. Multinomial logistic regression models were constructed with frailty status regressed on @entity73 and @entity73 , adjusting for covariates. RESULTS: Those who were frail showed a higher percentage of @entity73 (55.8% in @entity1 , 35.2% in @entity1 ) than those who were not (22.1% in @entity1 , 15.6% in @entity1 ). @entity73 was associated with an increased risk of frailty in @entity1 (odds ratio (OR) = 1.81, 95% confidence interval (CI): 1.25-2.60) and @entity1 (OR = 1.69, 95% CI: 1.25-2.30) even after controlling for all covariates. Among the @entity73 , time orientation, registration, attention, and judgment were associated with a lower likelihood of frailty in both @entity1 and @entity1 after adjusting for confounders. Among @entity1 higher scores on recall, language components, and visual construction were also significantly associated with lower odds of frailty. CONCLUSIONS: @entity73 was associated with a higher likelihood of frailty in community-dwelling older @entity1 and @entity1 . Total scores and specific @entity73 were inversely associated with frailty.

title: Association of XXXX with frailty in community-dwelling older adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'people', 'People']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'Cognitive impairment', 'subdomains of cognitive function']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive impairment']


abstract: BACKGROUND: High attack rates of Influenzavirus among school-aged @entity1 tend to be expected to cause significant disruption of usual activities at school and at home. OBJECTIVE: To quantify the effect of @entity683 season on @entity221 episodes, school absenteeism, medication use, parental absenteeism from work, and the occurrence of secondary @entity221 in families among a cohort of @entity1 enrolled in an elementary school during the 2000-2001 @entity683 season. DESIGN: Prospective survey study. SETTING: Kindergarten through eighth grade elementary school in Seattle, Wash. @entity1 OR OTHER @entity1 : All @entity1 enrolled in the school were eligible for the study. Study @entity1 were 313 @entity1 in 216 families. MAIN OUTCOME MEASURES: The primary outcome measure was missed school days. Secondary outcomes measures included @entity2749 , @entity221 episodes, medication usage, physician visits, parental workdays missed, and secondary illnesses among family members of @entity1 in the study cohort. Differences between the rates of study events among @entity1 when @entity683 was circulating and the event rates during the winter season when @entity683 was not circulating were used to calculate @entity683 -attributable excess events. RESULTS: @entity2749 , @entity221 episodes, analgesic use, school absenteeism, parental industrial absenteeism, and secondary @entity221 among family members were significantly higher during @entity683 season compared with the noninfluenza winter season. For every 100 @entity1 followed up for this @entity683 season, which included 37 school days, an excess 28 @entity221 episodes and 63 missed school days occurred. Similarly, for every 100 @entity1 followed up, @entity683 accounted for an estimated 20 days of work missed by the parents and 22 secondary @entity221 episodes among family members. CONCLUSION: Influenza season has significant adverse effects on the quality of life of school-aged @entity1 and their families.

title: Illness among schoolchildren during XXXX season: effect on school absenteeism, parental absenteeism from work, and secondary @entity221 in families.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'PATIENTS', 'PARTICIPANTS']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['illness', 'febrile illness']

entities_list: @entity2749 :: ('MESH:C580065', 'Disease') :: ['total illness episodes', 'Total illness episodes']

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza']