abstract: It has been proposed that diverse anticancer drugs and radiation therapy may induce a mode of cell death with the characteristics of apoptosis. Since apoptosis is under the control of several oncogenes, we analyzed the expression of the protein encoded by the proto-oncogenes @entity588 and @entity876 . Furthermore, we studied cell proliferation [using PC-10 mAb to @entity1364 ( @entity1364 )] and vascularization [using the CD-31 mAb and by counting intratumoral microvessel density (IMD)] using immunocytochemistry. A series of 73 @entity1 with clinical stage II-IV @entity957 of the head and neck (H_N) were treated with concurrent chemoradiation therapy ( @entity900 , 80 mg/m2, versus @entity3003 , 375 mg/m2, three times every 3 weeks and a total dose of radiation therapy of 64 Gy in 6-8 weeks). We correlated the expression of these markers, determined prior to treatment, with response to the therapy and prognosis. @entity588 protein was expressed in 37.4% of the @entity189 (25/67 evaluable), and it was not significantly associated with any other feature studied. Forty (56. 4%) of the 71 @entity189 evaluable for @entity876 were @entity876 positive; the median IMD was 38 microvessels/field at the hot spot (range, 18-80), and the median percentage of nuclei labeled by the PC-10 mAb was 50% (range, 0-95%). In the univariate analysis, regional lymph node negativity (P = 0.016), good performance status (PS) (PS >/= 90; P = 0.044), @entity588 positivity (P = 0.070), and low vascularization (P = 0. 085) were significantly associated with a higher probability of complete remission. In the multivariate analysis (final model), only IMD (continuous variable; P = 0.045) and PS (P = 0.017) retained significance. As far as prognosis is concerned, in the univariate analysis, @entity1 with @entity5 with low histological grading (grades 1-2; P = 0.006), @entity876 negative (P = 0.09), @entity588 positive (P = 0.08), and high @entity1364 labeling (P = 0.06) had a significantly better disease-free survival. In the multivariate analysis, only grading (P = 0.003) and @entity876 (P = 0.04) retained significance for disease-free survival. For overall survival, in the univariate analysis, the following markers were significantly prognostic when only deaths due to progression are considered: response to therapy (P = 0.00001), PS (P = 0.04), nodal status (P = 0.028), @entity1364 (P = 0.04), @entity876 (P = 0. 08), and grading (P = 0.01). In the multivariate analysis, only @entity1 who achieved complete response (P = 0.00002), high @entity1364 values (P = 0.002), and low histological grading (P = 0.01) retained a statistically significant probability of better overall survival. Our results suggest that in this series of H_N @entity5 @entity1 the markers capable of predicting response to therapy are distinct from those associated with prognosis, once the remission has been achieved. This information is potentially useful to the clinician for developing a more rational therapeutic approach for H_N @entity5 @entity1 eligible for concurrent chemoradiation therapy.

title: Predictive and prognostic markers in a series of @entity1 with head and neck XXXX treated with concurrent chemoradiation therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1364 :: ('5111', 'Gene') :: ['proliferating cell nuclear antigen', 'PCNA']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell invasive carcinoma']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous cell invasive carcinoma']


abstract: UNASSIGNED: @entity17953 and @entity17952 are likely ubiquitous organisms associated with @entity1 eyelashes. However, they have also been implicated in the pathogenesis of external @entity2194 . This article reviews the current literature in regards to life cycle, morphology, pathogenesis and treatment of underlying Demodex spp. @entity277 and outlines the previously undescribed in vivo behaviour of the mites. Images were obtained from the epilation of lashes from 404 @entity1 seen in clinical practice. Epilated lashes were placed on a microscope slide which had been coated with optically clear hypromellose/carbomer gel (Genteal gel, Novartis pharmaceuticals corporation, East Hanover, New Jersey). Adults were identified with either dark field or standard transmission microscopy at 40-100*. Eggs and other life-cycle stages were examined at 250* magnification, with transmission microscopy giving the best image resolution. The life cycle of the mite has been reviewed and simplified according to clinical observations. Clinical signs suggestive of underlying Demodex spp. @entity277 have been described, and their pathogenesis was explained based on the micrographic digital images obtained. The problem of symptomatic Demodex spp. disease likely reflects an imbalance in the external ocular ecology; however, the role of Demodex spp. as a commensal should not be overlooked. Treatment should not be aimed at total eradication of the mite but rather restoring the ocular ecology to a balanced state. By revisiting the life cycle of the mite, we can identify areas where possible intervention may be effective.

title: Demodex species in XXXX @entity2194 : new clinicopathological aspects.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular diseases']

entities_list: @entity17952 :: ('481310', 'Species') :: ['Demodex folliculorum']

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['infestation']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: A 67-year-old @entity1 was admitted in October 1987 with complaints of @entity390 , @entity10 , @entity1296 and speech disturbance. Hematological examination showed @entity3043 . Bone marrow aspiration failed with a dry tap. A month later, the second aspiration showed @entity236 containing 18.2% of @entity706 cells. Physical examination showed @entity381 and lymph node swelling. @entity4754 was not observed. A lymph node biopsy exhibited typical histology of @entity9233 ( @entity9233 )-like @entity784 . Surface marker CD3 and @entity404 positive cells were dominant. The @entity1 complained of @entity158 and occult blood was positive in stool. Gastrofiberscopic examination disclosed well differentiated @entity15709 located on a polyp, and polypectomy was performed. @entity706 was treated with @entity786 , @entity632 , @entity5713 and @entity617 . @entity381 and lymph node swelling were reduced in size but the effect was temporary. Thereafter the @entity1 has been treated with @entity786 , @entity632 , @entity7324 , @entity617 and etoposide every 3 weeks. This is our first case report of @entity9233 -like @entity784 associated with early @entity356 .

title: [ @entity9233 -like @entity784 associated with early XXXX : a case report].

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'Lymphoma']

entities_list: @entity7324 :: ('MESH:D014751', 'Chemical') :: ['vindesine']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell lymphoma']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly', 'Splenomegaly']

entities_list: @entity4754 :: ('MESH:D006942', 'Disease') :: ['Polyclonal hypergammaglobulinemia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['epigastric pain']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['hypocellular marrow']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity15709 :: ('MESH:D065311', 'Disease') :: ['adenocarcinoma in situ']

entities_list: @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']

entities_list: @entity9233 :: ('MESH:D007119', 'Disease') :: ['IBL', 'immunoblastic lymphadenopathy']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: @entity16509 ( @entity16509 ) comprise a family of basic- @entity368 zipper transcription factors that regulate cellular differentiation and function. To determine the role of @entity16509 transcription factors in osteoblasts and odontoblasts, we generated a transgenic (TG) @entity19 model with Co1a1 (pOBCol3.6) promoter-targeted expression of a FLAG-tagged dominant negative @entity16509 isoform, p20C/EBPbeta (previously @entity22705 ). Two of the four transgenic lines presented with abnormalities in the developing incisors, including breakage, overgrowth, and @entity3232 . Histological examination revealed that the amount of alveolar bone was reduced in TG compared to @entity164 ( @entity164 ) @entity19 . By microcomputed tomography (microCT), the bone volume fraction of the mandible was reduced at the level of the first and third molars, demonstrating a severe mandibular @entity2331 . The lingual dentin morphology of TG incisors differed dramatically from @entity164 . Labial dentin (enamel side) showed normal thickness and tubular dentin structure, whereas the lingual dentin was thinner (25-30% of @entity164 at the @entity4067 ) with an amorphous globular structure characteristic of @entity4368 . FLAG immunostaining was seen in both lingual and labial odontoblasts, indicating that the site-specific defect was not due to a lack of labial transgene expression. Northern blot analysis demonstrated reduced @entity2450 expression in TG mandibles, while bone sialoprotein was increased, consistent with prior results in calvariae and long bones. Dental sialophosphoprotein, a marker of the odontoblast lineage whose absence causes @entity4368 , was modestly reduced in TG @entity19 by Northern blot and in situ hybridization analysis. By fluorescence microscopy, pOBCol2.3-GFP, a marker of the odontoblast lineage, was expressed in both labial and lingual odontoblasts, although GFP-marked lingual odontoblasts were more flattened than @entity164 cells. Moreover, GFP-positive processes in the lingual dentin tubules were truncated and less organized than those in @entity164 dentin. MicroCT analysis showed reduced tissue density in the lingual dentin. These data suggest that @entity16509 transcription factors may be involved in the regulation of odontoblast polarization and dentin matrix production.

title: Mandibular phenotype of p20C/EBPbeta @entity19 : Reduced alveolar bone mass and site-specific XXXX .

entities_list: @entity4368 :: ('MESH:D003805', 'Disease') :: ['dentin dysplasia']

entities_list: @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine']

entities_list: @entity3232 :: ('MESH:D008310', 'Disease') :: ['malocclusion']

entities_list: @entity16509 :: ('12606(Tax:10090)', 'Gene') :: ['CCAAT enhancer binding proteins', 'C/EBP']

entities_list: @entity4067 :: ('MESH:D017675', 'Disease') :: ['alveolar crest']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia']

answer: @entity4368 :: (MESH:D003805,Disease) :: ['dentin dysplasia']


abstract: OBJECTIVE: In 1990, large-dose @entity134 administration was advocated in spine-injured @entity1 to @entity51 . The authors undertook both prospective and retrospective studies to evaluate the response of such profound pharmacologic intervention. SUMMARY BACKGROUND DATA: Of all sources of nonfatal @entity1566 remains the most devastating in both cost and impact on the quality of the @entity1 's life. One study found that routine large-dose @entity134 administration after injury lessened the extent of @entity16 . After uncommonly prompt and broad lay press publicity, this practice was widely accepted. Biased by knowledge of the known immunosuppressive effects of @entity230 , the authors suspected that @entity55 was both more frequent and severe in @entity134 -treated @entity1 . METHODS: Thirty-two @entity1 with cervical or upper @entity764 (C3-6, 20 @entity1 ; C6-7, 6 @entity1 ; and T1-6, 6 @entity1 ) were studied at an urban level I @entity130 center from January 1987 to February 1993. Complete @entity1566 was present in 22 of 32 @entity1 ; 14 @entity1 received @entity230 postinjury. There was no difference in mean age, cord level, age-adjusted injury severity score, or the percent of injury severity score caused by the @entity3510 . RESULTS: The length of hospital stay was longer in @entity134 -treated @entity1 (S) than in nonsteroid (NS) @entity1 , that is, 44.4 days versus 27.7 days, respectively (p = 0.065). Seventy-nine per cent of S @entity1 had @entity55 compared with 50% of NS @entity1 (p = 0.614). There was no statistical difference in the episodes of @entity55 per @entity1 between the two groups (p > 0.05). Prospectively, the authors evaluated sequentially several parameters known to be important in @entity1 immune responses to bacterial challenges in nine S and five NS @entity1 . In S @entity1 , both the per cent and density of monocyte class II antigen expression and T-helper/suppressor cell ratios were lower than in NS @entity1 . However, S @entity1 did have an initially higher, earlier boost in some host defense parameters that rapidly declined, and their subsequent response was both blunted and delayed. These differences became even clearer when stratified according to cord level and incomplete versus complete cord status. Not surprisingly, infected @entity1 , whether S or NS, had lower levels of monocyte antigen expression, @entity9637 , and helper/suppressor ratios. CONCLUSIONS: These data do not permit a judgment to be made whether neurologic status was improved by S administration. It is known that vital immune responses were adversely affected, that @entity55 was somewhat more prevalent, and that hospitalization was prolonged and costs therefore increased by an average of  51,504 per admission. Further clinical studies will be needed to determine to what extent these observations offset the putative benefits of large-dose @entity230 in the treatment of spinal @entity130 .

title: The two-edged sword of large-dose @entity230 for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity3510 :: ('MESH:D013124', 'Disease') :: ['spinal injury']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic injury']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['lessen neurologic deficits']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['thoracic spinal injuries']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['injury, spinal cord trauma', 'spinal cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord trauma']


abstract: @entity995 (Rb) @entity5 suppressor protein is widespread in @entity1 @entity5 . Inactivation of Rb is thought to be initiated by association with @entity10242 , and here we determined how @entity48965 , a disruptor of the Rb-Raf-1 interaction, affects @entity788 progression. Assessment of phospho-Rb levels in resected @entity1 @entity788 specimens by immunohistochemistry (n = 95) showed that increased Rb phosphorylation correlated with increasing grade of resected @entity1 pancreatic @entity420 (P = 0.0272), which correlated with reduced overall @entity1 survival (P = 0.0186). To define the antitumor effects of @entity48965 (50  mol/L), cell-cycle analyses, senescence, cell viability, cell migration, anchorage-independent growth, angiogenic tubule formation and invasion assays were conducted on @entity136 -sensitive and -resistant @entity788 cells. @entity48965 prevented S-phase entry, induced senescence and apoptosis, and inhibited anchorage-independent growth and invasion (P < 0.01). Drug efficacy on subcutaneous and orthotopic xenograft models was tested by intraperitoneal injections of @entity48965 (50 mg/kg) alone or in combination with @entity136 (250 mg/kg). @entity48965 significantly reduced @entity5 growth in vivo accompanied by reduced Rb phosphorylation and lymph node and liver @entity3 (P < 0.01). Combination of @entity48965 with @entity136 showed cooperative effect on @entity5 growth (P < 0.01). In conclusion, disruption of the Rb-Raf-1 interaction significantly reduces the malignant properties of @entity788 cells irrespective of their @entity136 sensitivity. Selective targeting of Rb-Raf-1 interaction might be a promising strategy targeting @entity788 .

title: Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic @entity420 growth irrespective of XXXX sensitivity.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['Inactivation of the retinoblastoma']

answer: @entity136 :: (MESH:C056507,Chemical) :: ['gemcitabine']


abstract: PURPOSE: @entity8479 ( @entity8479 ) causes @entity358 in @entity1 after @entity548 resuscitation. We performed intra-abdominal volume increment (IAVI) to @entity8479 and studied its effect on pulmonary function. METHODS: Eight minipigs established for @entity8479 model by exsanquination until shock, incomplete blockage of portal vein and overload resuscitation were randomly divided into IAVI group (n=4) and sham-operated control group (n=4). Bladder pressure, arterial blood gas analysis and thoraco-abdominal computed tomography (CT) scans were measured. The minipigs were sacrificed 26 h after surgery, and lung samples were harvested for measuring the wet-to-dry weight ratio and @entity1710 - @entity1711 staining. RESULTS: Compared with sham-operated control group, the respiratory rate and paCO2 remarkably decreased and paO2 notably increased at 8 and 12 h in the IAVI group. The bladder pressure also notably decreased at 8, 12, and 22 h after IAVI treatment. However, a significant improvement in diaphragm height was observed at 22 h after IAVI treatment. The wet-to-dry weight ratio of the lungs in IAVI group was also significantly higher than that that in the sham-operated control group. CONCLUSION: Our data indicate that IAVI surgery could improve the damaged pulmonary function caused by @entity8479 after @entity548 resuscitation (Tab. 1, Fig. 7, Ref. 21).

title: Effect of intra-abdominal volume increment on lungs in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock']

entities_list: @entity8479 :: ('MESH:D059325', 'Disease') :: ['Intra-abdominal hypertension', 'IAH']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung dysfunction']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhagic shock']


abstract: BACKGROUND: Synchronized cardioversion is generally accepted as safe for the treatment of @entity1165 and @entity955 when @entity1457 are synchronized to the R wave and delivered transthoracically. However, others have shown that during attempted transvenous cardioversion of rapid @entity1165 , @entity2224 ( @entity2224 ) may be induced. It was our objective to evaluate conditions (short and irregular cycle lengths [CL]) under which @entity2224 might be induced during synchronized electrical conversion of @entity955 with transvenous electrodes. METHODS AND RESULTS: In 16 @entity742 (weight, 62 +/- 7.8 kg), @entity955 thresholds (ADFT) were determined for a 3-ms/3-ms @entity1457 delivered between two catheters each having 6-cm coil electrodes, one in the great cardiac vein under the left atrial appendage and one in the right atrial appendage along the anterolateral atrioventricular groove. A hexapolar mapping catheter was positioned in the right ventricular apex for shock synchronization. In 8 @entity742 (group A), a shock intensity 20 V less than the ADFT was used for testing, and in the remaining 8 @entity742 (group B), a shock intensity of twice ADFT was used. With a modified extrastimulus technique, a basic train of eight stimuli alone (part 1) and with single (part 2) and double (part 3) extrastimuli were applied to right ventricular plunge electrodes. @entity955 @entity1457 were delivered synchronized to the last depolarization. In part 4, @entity1457 were delivered during @entity955 . The preceding CL was evaluated over a range of 150 to 1000 milliseconds. Shocks were also delayed 2, 20, 50, and 100 milliseconds after the last depolarization from the stimulus (parts 1 through 3) or intrinsic depolarization (part 4). The mean ADFT for group A was 127 +/- 48 V, 0.71 +/- 0.60 J and for group B, 136 +/- 37 V, 0.79 +/- 0.42 J (NS, P > .15). Of 1870 @entity1457 delivered, 11 episodes of @entity2224 were induced. Group A had no episodes of @entity2224 in part 1, two episodes of @entity2224 in part 2 (CL, 240 and 230 milliseconds with 2-millisecond delay), and one episode each in parts 3 (CL, 280 milliseconds with 2-millisecond delay) and 4 (CL, 240 milliseconds with 100-millisecond delay). Group B had two episodes in part 1 (CL, 250 and 300 milliseconds with 20-millisecond delay), three episodes in part 2 (CL, 230, 230, and 250 milliseconds with 2-millisecond delay), and one episode each in parts 3 (CL, 260 milliseconds with 2-millisecond delay) and 4 (198 milliseconds with 100-millisecond delay). No episodes of @entity2224 were induced for @entity1457 delivered after a CL > 300 milliseconds. CONCLUSIONS: Synchronized transvenous @entity955 @entity1457 delivered on beats with a short preceding ventricular cycle length (< 300 milliseconds) are associated with a significantly increased risk of initiation of @entity2224 . To decrease the risk of @entity67 , short CLs should be avoided.

title: Ventricular proarrhythmic effects of ventricular cycle length and shock strength in a @entity742 model of transvenous XXXX .

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['shocks', 'biphasic shock']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'ventricular fibrillation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial defibrillation', 'atrial defibrillation']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular proarrhythmia']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial defibrillation']


abstract: This study presents data on the incidence of @entity4963 in a Portuguese oncology hospital during a 6-year period. The species distribution and their antifungal susceptibility, as well as the clinical outcomes associated with @entity4963 were evaluated. A total of 119 episodes were reported, with the majority occurring among @entity1 older than 56 years. The most common underlying medical conditions were solid @entity5 (64.5%) and @entity1503 (28.2%). The most frequent species found was @entity5132 (48.7%), followed by @entity7409 (20.2%), @entity9841 (8.4%), C. krusei (6.7%) and @entity7408 (5.0%), but @entity375 and Rhodotorula mucilaginosa were also isolated. @entity5132 was more frequently associated with solid @entity5 of the gastrointestinal and genitourinary tracts and breast (P=0.005), while non- @entity5132 Candida species were most frequently recovered from hematological @entity1 (P=0.007). The mortality rate associated with @entity4963 was 31.9% (P=0.016). All @entity5132 and @entity7409 isolates were susceptible to @entity2380 , @entity5074 and @entity2059 . Resistance to @entity11794 was only observed in @entity5132 and in the @entity23140 isolates. @entity7143 was active against all @entity7409 isolates tested but resistant strains were found among @entity5132 (4.9%), @entity9841 (12.5%), C. krusei (25%) and @entity7408 (50%). This study provides useful information regarding the local epidemiology of @entity4963 in @entity5 @entity1 .

title: Epidemiology of @entity4963 in oncology XXXX : a 6-year survey in a Portuguese central hospital.

entities_list: @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity4963 :: ('MESH:D058387', 'Disease') :: ['candidemia']

entities_list: @entity7409 :: ('5480', 'Species') :: ['C. parapsilosis']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological disease']

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans']

entities_list: @entity5074 :: ('MESH:C102790', 'Chemical') :: ['voriconazole']

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

entities_list: @entity7143 :: ('MESH:C101425', 'Chemical') :: ['Posaconazole']

entities_list: @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole']

entities_list: @entity11794 :: ('MESH:C105417', 'Chemical') :: ['caspofungin']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: This is a phase II clinical study conducted to evaluate the @entity137 and efficacy of a 4-day regimen of @entity1205 , @entity900 , @entity1487 , and @entity4181 (TPFL) in @entity1 with locoregionally advanced @entity213 ( @entity213 ). @entity1 AND METHODS: Twenty-one previously untreated @entity1 with stage III or IV @entity213 were treated with TPFL. @entity1 who received a complete response (CR) or partial response (PR) to three cycles of TPFL received definitive radiation therapy. The primary end points were @entity137 and response to TPFL. RESULTS: Fifty cycles were administered to 21 @entity1 . The major acute @entity137 to TPFL were @entity33 , @entity1295 , and @entity448 . Additional major @entity137 were @entity1398 , @entity417 , and @entity353 . The overall clinical response rate to TPFL was 47.6% , with 19% CRs and 28.6% PRs. In addition, the median time to progression and overall survival time were 49.2 months and 42.7 months, respectively. CONCLUSION: TPFL has an acceptable @entity137 profile for @entity1 with locally advanced @entity213 and may hold curative potential for some @entity1 with surgically unresectable or medical inoperable situations. OBJECTIVE: To evaluate the efficacy and safety to TPFL regimen for locally advanced @entity213 .

title: Taxotere, @entity900 , @entity1487 , and @entity4181 (TPFL)as induction chemotherapy for locally advanced XXXX .

entities_list: @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['squamous cell carcinoma of the head and neck', 'SCCHN']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity213 :: (MESH:C535575,Disease) :: ['squamous cell carcinoma of the head and neck']


abstract: OBJECTIVES: To explore the experience of @entity25 over the first 2   years after @entity131 ( @entity131 ). DESIGN: Longitudinal qualitative descriptive analysis of interviews completed as part of a larger longitudinal study of recovery following @entity131 . Data relating to the experience of @entity1295 and/or sleep were extracted and coded by two independent researchers. SETTING: Community-based study in the Hamilton and Auckland regions of New Zealand. @entity1 : 30 adult @entity1 who had experienced mild, moderate or severe @entity1545 within the past 6   months (>16   years of age). 15 @entity1 also nominated significant others to take part. Interviews were completed at 6, 12 and 24   months postinjury. RESULTS: @entity1 described feeling unprepared for the intensity, impact and persistent nature of @entity25 after injury. They struggled to learn how to manage their difficulties by themselves and to adapt strategies in response to changing circumstances over time. Four themes were identified: (1) Making sense of @entity1295 and sleep after @entity131 ; (2) accepting the need for rest; (3) learning how to rest and; (4) need for rest impacts on ability to engage in life. CONCLUSIONS: Targeted support to understand, accept and manage the sleep and @entity1295 experienced may be crucial to improve recovery and facilitate engagement in everyday life. Advice needs to be timely and revised for relevance over the course of recovery.

title: Exploring the experience of sleep and @entity1295 in male and female adults over the 2   years following XXXX : a qualitative descriptive study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'PARTICIPANTS']

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue difficulties', 'fatigue']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['fatigue and sleep difficulties']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: Photochemical cross-linking of @entity526 @entity5537 -DNA glycosylase (Ung) to oligonucleotide @entity48637 was performed to identify @entity535 residues that reside in or near the DNA-binding site. UV-catalyzed cross-linking reactions produced a covalent Ung x @entity48637 complex which was resolved from uncross-linked enzyme by @entity214 - @entity2975 gel electrophoresis. Cross-link formation required native Ung and was inhibited by increasing concentrations of @entity1219 in a manner characteristics of @entity1219 inhibition of Ung catalytic activity. The Ung x @entity48637 complex was purified to apparent homogeneity, and mass spectrometry revealed that Ung was cross-linked to @entity48637 in 1:1 stoichiometry as a 31,477 dalton complex. Purified Ung x @entity48637 lacked detectable @entity5537 -DNA glycosylase activity and failed to bind single-stranded DNA. Recently, we demonstrated that the bacteriophage PBS2 @entity5537 -DNA glycosylase inhibitor (Ugi) binds Ung and prevents further interaction with DNA (Bennett, S. E., Schimerlik, M. I., and Mosbaugh, D. W. (1993) J. Biol. Chem. 268, 26879-26885). Addition of the Ugi protein to the cross-linking reaction blocked formation of the Ung x @entity48637 cross-link. Conversely, the Ung x @entity48637 cross-link was refractory to Ugi binding. Upon trypsin digestion of Ung x @entity48637 , four distinct products were identified as peptide x @entity48637 cross-links. A combination of @entity535 sequence and mass spectrometric analysis revealed that four tryptic peptides (T6, T18, T19, and T18/19) were adducted to @entity48637 . These observations suggest that @entity48637 is cross-linked to the Ung DNA-binding site.

title: UV-catalyzed cross-linking of @entity526 XXXX -DNA glycosylase to DNA. Identification of @entity535 residues in the single-stranded DNA binding site.

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity5537 :: (MESH:D014498,Chemical) :: ['uracil']


abstract: An experimental model for induction of @entity11 corresponding to @entity1 @entity816 and @entity463 is reported. Eleven week old F344 and ACI @entity35 were given 100 or 200 p.p.m. @entity7044 ( @entity7045 ) solution as their drinking water for 42 weeks. @entity11 were induced at very high incidences (82.5-92.5%) in each group. Induced @entity11 showed apparent evidence of morphologic @entity5 by an analysis based on diagnostic criteria of @entity1 @entity816 . All of the @entity11 from the killed animals were classified histologically into subtypes according to the classification scheme used in the diagnosis of @entity1 @entity11 . The majority of macrotumors more than 1 mm in diameter in both strains were diagnosed as @entity816 and @entity463 . Immunohistochemically, @entity5 cells in these @entity5 were almost negative for glial fibrillary acidic protein, while ultrastructurally neoplastic astrocytes contained glial filaments. A strain difference was observed in the ratio of histological subtypes of macrotumors. In F344 @entity35 , @entity5 diagnosed as @entity816 and @entity463 of an astrocytic type formed the majority, whereas @entity463 of mixed oligo-astrocytic type predominated in ACI @entity35 . The results indicate that @entity7045 -administration to adult F344 @entity35 may provide a suitable experimental model for @entity11 which occur in adult @entity1 .

title: An experimental model for @entity816 and @entity463 using adult F344 XXXX and @entity7044 .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'astrocytic tumors', 'malignancy']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas', 'Gliomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas', 'astrocytomas']

entities_list: @entity7044 :: ('MESH:D008770', 'Chemical') :: ['N-methyl-N-nitrosourea']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Background: Urokinase or two-chain urokinase-type plasminogen activator has been shown to be effective in the treatment of @entity583 . Its parent molecule, single-chain urokinase-type plasminogen activator (scu-PA), unlike urokinase, can selectively activate fibrin-bound plasminogen. The induced clot lysis is amplified by plasmin-triggered conversion of scu-PA to urokinase and by further plasmin generation. The aim of our study was to compare the efficacy and safety of recombinant unglycosylated scu-PA, or saruplase, and urokinase at doses considered optimal in @entity1 with @entity583 within 6 hours of onset of @entity158 . Methods and results: In a double-blind trial 543 @entity1 were randomized to saruplase (20 mg bolus + 60 mg/hr) or urokinase (1.5 million unit bolus + 1.5 million units/hr). Primary endpoint: The patency rates at 24-72 hours were 75.4% (95% CI 70.3-80.5%) for saruplase and 74.2% (95% CI 69.0-79.4%; P = 0.77) for urokinase. Secondary endpoint: The incidence of @entity548 events in both groups was 10.7%. There were three @entity64 in the saruplase group (ns). Other efficacy and safety evaluations: Apart from the generation of more fibrinogen degradation products under saruplase, the changes in hemostatic parameters did not differ. Hospital mortality was 4.4% for saruplase and 8.1% for urokinase. This nonsignificant difference was maintained for 1 year. Conclusion: The efficacy and safety of saruplase and urokinase in the regimens used are very similar.

title: A Double-Blind Multicenter Comparison of the Efficacy and Safety of Saruplase and Urokinase in the Treatment of Acute XXXX : Report of the SUTAMI Study Group.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['hemorrhagic strokes']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']


abstract: BACKGROUND: Psoriasis is a chronic @entity272 with a major impact on the quality of life of affected individuals. Topical therapy has an important role in the treatment of @entity1569 . Poor treatment outcomes from topical therapy regimens likely result from poor adherence and ineffective use of medication. METHODS: A cost-minimization analysis was performed with the purpose of assessing the use of a gel containing @entity2116 and @entity9090 (Dovobet(  ) gel) versus the ointment formulation (Dovobet ointment) in the treatment of @entity1569 . The analysis was carried out using a Markov model with a one-year time horizon in a hypothetical cohort of @entity1 with a Psoriasis Area and Severity Index score < 10. The model simulates different therapy adherence scenarios for the two different formulations. RESULTS: The Dovobet gel strategy allows a 5% reduction in the number of @entity1 who could potentially be treated with more expensive therapies (biologics and conventional systemic drugs) in comparison with the Dovobet ointment strategy, with a consequent impact on costs for the National Healthcare Service. The total annual cost of Dovobet gel is about    407.00 per @entity1 , ie, 19% less that the total cost of about    500.00 of the Dovobet ointment strategy. The base case results were then examined by sensitivity analysis and budget impact analysis to correlate the various scenarios of Dovobet gel use with cost savings to the National Healthcare Service. CONCLUSION: The Dovobet gel strategy seems more acceptable to @entity1 , shows better overall adherence, and appears to be favorable from the pharmacoeconomic point of view than the ointment formulation for treatment of @entity1 with mild-to-moderate @entity1569 .

title: @entity2116 and XXXX in the treatment of mild-to-moderate @entity1569 : a cost-effectiveness analysis of the ointment versus gel formulation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity9090 :: ('MESH:C011175', 'Chemical') :: ['betamethasone dipropionate']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['inflammatory skin disease']

entities_list: @entity2116 :: ('MESH:C055085', 'Chemical') :: ['calcipotriol']

answer: @entity9090 :: (MESH:C011175,Chemical) :: ['betamethasone dipropionate']


abstract: BACKGROUND: We evaluated the clinical characteristics and treatment outcomes of @entity1 with @entity6275 in the foot and ankle in @entity1 without @entity6 . METHODS: We reviewed 15 @entity1 treated for @entity6275 involving the foot and ankle between September 2004 and March 2007. @entity1 with @entity6 or who were immunocompromised were excluded. The cause of @entity4034 , sites of occurrence, causative pathogens, and invasion of the adjacent joint(s) were reviewed, then the clinical characteristics were analyzed. Magnetic resonance imaging was performed to clarify the extent of @entity281 and invasion of the adjacent joint. Surgical management included wide debridement, dead space control, and arthrodesis if there was invasion of the adjacent joint. The mean postoperative followup period was 3.3 years, during which recurrences and complications were evaluated. RESULTS: Extrinsic causes accounted for 86.7% of the @entity6275 involving the foot and ankle. The most common cause of @entity4034 was @entity130 with ten cases due to complications following @entity174 or @entity3029 . @entity3256 -resistant @entity794 and Pseudomonas were the most common causative pathogens. In 46.7% of the @entity1 , the adjacent joint was involved and an arthrodesis was performed. The mean length of the hospital stay was 39.1 days. The average of number of surgeries was two. Fourteen of 15 @entity1 had no recurrence. CONCLUSION: For the successful treatment of @entity6275 involving the foot and ankle, an arthrodesis based on invasion of the adjacent joint as well as wide debridement and dead space control was successful in this series.

title: Surgical treatment of XXXX involving the foot and ankle.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6275 :: ('MESH:C535456', 'Disease') :: ['chronic osteomyelitis']

entities_list: @entity3256 :: ('MESH:D008712', 'Chemical') :: ['Methicillin']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity3029 :: ('MESH:D004204', 'Disease') :: ['dislocation']

answer: @entity6 :: (MESH:D003920,Disease) :: ['non-diabetic chronic osteomyelitis']


abstract: @entity3398 , @entity12092 , and @entity33910 were compared in 10-day therapy of intra-abdominal and subcutaneous @entity281 caused by three organisms: @entity2868 and @entity3404 combined with either @entity526 or @entity794 . @entity1320 was caused by @entity2868 plus @entity3404 plus @entity526 . Therapy was initiated immediately before inoculation or was delayed for 8 h. Mortality was 14 of 30 (47%) for saline-treated @entity19 , and all survivors developed abscesses. Immediate therapy reduced mortality and the percentage of @entity19 with abscesses (in survivors), respectively, to 17 and 20% with @entity3398 , 0 and 13% with @entity12092 , and 0 and 17% with @entity33910 , and the numbers of all bacteria were reduced by all the cephalosporins. Delayed therapy reduced mortality and @entity733 formation, respectively, to 20 and 8% of @entity19 with @entity3398 , 10 and 93% with @entity12092 , and 7 and 96% with @entity33910 . @entity3404 survived in all abscesses treated with @entity12092 and @entity33910 . Subcutaneous abscesses were caused by each organism alone or in combinations of one aerobe ( @entity794 or @entity526 ) and one or two @entity3404 species. Early therapy reduced the numbers of all bacteria independent of their in vitro susceptibility. All agents reduced the number of each @entity3404 species with either @entity526 or @entity794 . However, when therapy was delayed, @entity12092 and @entity33910 were less effective than @entity3398 against @entity3404 . @entity12092 was the most active agent against @entity526 , and @entity33910 was the most effective against @entity794 . These data illustrate the efficacy of all tested @entity2886 in the prophylaxis of @entity325 .

title: Use of cephalosporins for prophylaxis and therapy of @entity325 in XXXX .

entities_list: @entity2868 :: ('817', 'Species') :: ['B. fragilis', 'Bacteroides fragilis']

entities_list: @entity3404 :: ('818', 'Species') :: ['Bacteroides thetaiotaomicron', 'B. thetaiotaomicron', 'Bacteroides']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus']

entities_list: @entity33910 :: ('MESH:D015311', 'Chemical') :: ['cefmetazole']

entities_list: @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity12092 :: ('MESH:D015313', 'Chemical') :: ['Cefotetan', 'cefotetan']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['polymicrobial infections']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['Intra-abdominal infection']

entities_list: @entity3398 :: ('MESH:D002440', 'Chemical') :: ['cefoxitin', 'Cefoxitin']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: Non-invasive methods for diagnosis of @entity189 have reduced specificity in @entity1 with non-malignant @entity74 . We aimed to use mass spectrometry and bioinformatics to define and validate a @entity5 -specific proteomic pattern. METHODS: We used capillary-electrophoresis-coupled mass spectrometry to obtain polypeptide patterns from urine samples of 46 @entity1 with @entity189 and 33 healthy volunteers. From signatures of polypeptide mass, we established a model for predicting the presence of @entity5 . The model was refined further by use of 366 urine samples obtained from other healthy volunteers and @entity1 with malignant and non-malignant @entity6982 . We estimated the proportion of correct classifications from the refined model by applying it to a masked group containing 31 @entity1 with @entity189 , 11 healthy individuals, and 138 @entity1 with non-malignant @entity6982 . We also sequenced several diagnostic polypeptides for @entity189 . FINDINGS: We identified a diagnostic @entity189 pattern of 22 polypeptide masses. On masked assessment, prediction models based on these polypeptides correctly classified all samples of @entity189 (sensitivity 100% [95% CI 87-100) and all healthy samples (specificity 100% [84-100]). Correct identification of @entity1 with @entity189 from those with other malignant and non-malignant @entity6982 ranged from 86% to 100%. A prominent polypeptide from the diagnostic pattern for @entity189 was identified as fibrinopeptide A-a known biomarker of @entity43 and @entity356 . INTERPRETATION: Validation of a highly specific biomarker pattern for @entity189 in a large group of @entity1 with various @entity5450 could be used in the diagnosis of other diseases that are identified in urine samples or in other body fluids.

title: Discovery and validation of new protein biomarkers for XXXX : a prospective analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity6982 :: ('MESH:D052801', 'Disease') :: ['genitourinary disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity5450 :: ('MESH:D014570', 'Disease') :: ['urological disorders']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma', 'urothelial-carcinoma']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genitourinary disease or other disorders']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['urothelial cancer']


abstract: One hundred thirty consecutive @entity1 with metastatic @entity1745 (MSCC) were entered in a therapeutic protocol in which @entity1161 ( @entity1161 ) played the main role. When MSCC is diagnosed by clinical-radiologic methods such as myelography with or without computed tomography (CT) or magnetic resonance imaging (MRI), @entity230 are given and @entity1161 treatment started within 24 hours. When diagnostic doubts exist or stabilization is necessary, surgery precedes @entity1161 . @entity5 are also treated with chemotherapy or hormonal therapy. Twelve @entity1 (9.2%) underwent surgery plus @entity1161 , and 118 (90.8%) received @entity1161 alone. Thirteen (11%) early @entity204 @entity1 were not evaluable. The 105 evaluable cases that received @entity1161 alone were analyzed. Median follow-up was 15 months (range, 4 to 38 months). Response among @entity1 with @entity615 was 80%. In cases with @entity66 , 48.6% improved, and in 33 of 105 @entity1 (31.4%) without motor disability there was no deterioration. Forty percent of @entity1 with @entity5433 responded to @entity1161 . Median survival time was 7 months with a 36% probability of survival for 1 year. The median duration of improvement was 8 months. The most important prognostic factor was early diagnosis. @entity5 was only important in paraparetic @entity1 in predicting response to @entity1161 . Complete @entity616 significantly diminished response to @entity1161 . @entity891 did not influence response or survival.

title: Radiation therapy in metastatic @entity1745 . A prospective analysis of 105 consecutive XXXX .

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['motor dysfunction']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Radiosensitivity of tumor', 'Chemohormonal potentially responsive tumors']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain']

entities_list: @entity891 :: ('MESH:D001261', 'Disease') :: ['Vertebral collapse']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['myelographic block']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Altered reward circuitry function is observed in individuals with @entity162 ( @entity162 ) and their unaffected offspring ( @entity44950 ). While @entity44950 are at elevated risk for @entity162 , modifiable risk factors that may exacerbate neural vulnerabilities in @entity44950 remain under-characterized. As @entity25 is strongly linked to @entity162 in @entity162 , this study tested associations between sleep duration, reward circuitry function, and @entity1316 in @entity44950 . METHODS: Two groups of youth unaffected with @entity162 (9-17yr) completed a number-guessing fMRI reward paradigm: 25 @entity44950 and 21 age-sex-IQ-matched offspring of control parents with non- @entity162 psychopathology (OCP), to differentiate risk for @entity162 from risk for psychopathology more broadly. Regressions tested effects of group status, self-reported past-week sleep duration, and their interaction on neural activity and bilateral ventral striatum (VS) functional connectivity to win>control. Correlations with parent-reported @entity1316 were assessed. RESULTS: Group effects were observed for right posterior insula activity (OCP> @entity44950 ) and VS-left posterior insula connectivity ( @entity44950 >OCP). Group(   )sleep duration interactions were observed for left dorsal anterior-mid-cingulate (daMCC) activity and VS-left anterior insula/ventrolateral prefrontal cortex (VLPFC) connectivity. Specifically, sleep duration and daMCC activity were positively related in @entity44950 , but negatively related in OCP and sleep duration and VS-left anterior insula/VLPFC connectivity were negatively related in @entity44950 , but positively in OCP. Additionally, increased VS-left posterior insula connectivity and VS-left anterior insula/VLPFC connectivity were associated with greater @entity1316 in @entity44950 only. LIMITATIONS: Cross-sectional design and small sample size. CONCLUSIONS: Altered reward-related VS-insula connectivity could represent a neural pathway underpinning @entity1316 in @entity44950 , and may be modulated by shortened sleep duration.

title: Preliminary investigation of the relationships between sleep duration, reward circuitry function, and XXXX in youth offspring of parents with @entity162 .

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood dysregulation']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'BD', 'mania']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep loss']

answer: @entity1316 :: (MESH:D019964,Disease) :: ['mood dysregulation']


abstract: OBJECTIVE: To determine if rectal myectomy is an effective treatment for a specific group of @entity1 with @entity1963 . DESIGN: Retrospective series with follow-up of 6 to 132 months (mean follow-up, 37.1 months). SETTING: @entity1 's hospital. @entity1 : Fourteen @entity1 aged 2 to 14 years with chronic @entity1142 and nondiagnostic barium enema contrast study findings. INTERVENTION: Posterior rectal myectomy. MAIN OUTCOME MEASURES: Laxative use, frequency of stools, incidence of soiling or @entity322 , and @entity1 's assessment of improvement. RESULTS: The conditions of all 14 @entity1 improved regardless of the presence of ganglion cells in the myectomy specimen; there were six excellent, six good, and two fair assessments. laxatives were used intermittently by seven of 14 @entity1 . No @entity1 complained of @entity322 or soiling. CONCLUSIONS: Rectal myectomy is an effective, less-extensive operation that should be considered for older @entity1 with @entity1963 .

title: Limited surgery for lower-segment XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient', 'PATIENTS']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1963 :: ('MESH:D006627', 'Disease') :: ["Hirschsprung's disease"]

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

answer: @entity1963 :: (MESH:D006627,Disease) :: ['Hirschsprung's disease']


abstract: BACKGROUND: The aim was to examine mortality in @entity146 @entity1 in @entity8928 ( @entity8928 ), over a time period of considerable change in the delivery of mental health services. METHODS: A population-based record linkage analysis was undertaken to quantify mortality among @entity1 with @entity1032 in @entity8928 . Mortality rates were calculated in users of mental health services and compared with rates in the whole population of @entity8928 . Trends in mortality were also examined using relative survival analysis, and proportional hazards regression. RESULTS: The overall mortality rate ratio was 2.57 in males (95% CI: 2.51-2.64), and 2.18 in females (2.12-2.24). The highest cause-specific mortality rate ratio was for deaths due to suicide [RR: 7.37 in males (95% CI: 6.74-8.05) and 8.38 in females (95% CI: 7.11-9.89)], with mortality rate ratios being significantly greater than 1 for all other major causes of @entity204 . A relative survival analysis found that the excess mortality risk was concentrated in the first few years after first contact with mental health services. Proportional hazards regression analysis found a slight elevation of mortality rates over time. CONCLUSIONS: Mortality among @entity146 @entity1 remains high and appears to be increasing. Highest excess mortality rate is associated with suicide, but mortality rates are significantly elevated for all major causes of @entity204 .

title: Mortality in Western Australian @entity146 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness']

entities_list: @entity8928 :: ('MESH:D020241', 'Disease') :: ['Western Australia', 'WA']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A @entity17589 complicating @entity4943 ( @entity4943 ) has been recognised and designated @entity20281 ( @entity20281 ). @entity4943 is characterised by profound character change and altered social conduct, and @entity51 , reflecting focal degeneration of the frontal and temporal neocortex. The @entity17589 comprises @entity10296 and @entity4218 . The major histological change is typically of microvacuolation of the cerebral cortex, with @entity194 of the bulbar neurones and anterior horn cells of the spinal cord. Ubiquitinated inclusion bodies occur in large pyramidal cortical neurones and in surviving cranial nerve nuclei and anterior horn cells. Evidence is emerging that some @entity1 with classical @entity746 ( @entity746 ), who are thought not to be demented, develop @entity73 in the realm of frontal executive functions. Moreover, frontal @entity75 have been demonstrated by neuroimaging. The findings point to a link between @entity4943 / @entity20281 and cMND/ @entity746 and suggest that a proportion of @entity1 with cMND/ @entity746 go on to develop @entity4943 . @entity1 with cMND/ @entity746 may not be equally vulnerable. The hypothesis is that @entity1 who present with @entity10296 and @entity3949 , rather than corticospinal and corticobulbar features, may be most susceptible to the development of @entity4943 .

title: @entity73 in motor neurone disease/ @entity746 ( @entity20281 / XXXX ).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity10296 :: ('MESH:D010244', 'Disease') :: ['bulbar palsy']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['lobe abnormalities']

entities_list: @entity4218 :: ('MESH:D017880', 'Disease') :: ['limb amyotrophy']

entities_list: @entity3949 :: ('MESH:D003929', 'Disease') :: ['amyotrophy']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['executive deficits']

entities_list: @entity20281 :: ('MESH:C566288', 'Disease') :: ['MND', 'FTD/motor neurone disease']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'MND/amyotrophic lateral sclerosis']

entities_list: @entity4943 :: ('MESH:D057180', 'Disease') :: ['FTD', 'frontotemporal dementia']

entities_list: @entity17589 :: ('MESH:D009134', 'Disease') :: ['motor neuronopathy']

answer: @entity746 :: (MESH:D000690,Disease) :: ['ALS']


abstract: Stereotactic radiosurgery (SRS) to a @entity954 after brain @entity3 resection is a promising treatment for improving local control.  The optimal timing of adjuvant SRS, however, has yet to be determined. Changes in resection cavity volume and local progression in the interval between surgery and SRS are likely important factors in deciding when to proceed with adjuvant SRS. We conducted a retrospective review of @entity1 with a brain @entity3 treated with surgical resection followed by SRS to the resection cavity. Post-operative and pre-radiosurgery magnetic resonance imaging (MRI) was reviewed for evidence of cavity volume changes, amount of @entity4 , and local @entity5 progression.  Resection cavity volume and @entity4 volume were measured using volumetric analysis. We identified 21 consecutive @entity1 with a brain @entity3 treated with surgical resection and radiosurgery to the resection cavity.  Mean age was 57 yrs.  The most common site of @entity3 was the frontal lobe (38%), and the most common primary @entity5 were @entity2220 and @entity320 (24% each).  The mean postoperative resection cavity volume was 7.8 cm(3) and shrank to a mean of 4.5 cm(3) at the time of repeat imaging for radiosurgical planning (median 41 days after initial post-operative MRI), resulting in a mean reduction in cavity volume of 43%.  @entity1 who underwent pre-SRS imaging within 1 month of their initial post-operative MRI had a mean @entity353 of 13% compared to 61% in those whose pre-SRS imaging was >= 1 month (p=0.0003). Post-resection @entity4 volume was not related to @entity353 (p=0.59). During the interval between MRIs, 52% of @entity1 showed evidence of @entity5 progression within the resection cavity wall. There was no significant difference in local recurrence if the interval between resection and radiosurgery was <1 month (n=8) versus >= 1 month (n=13, p=0.46). These data suggest that the @entity954 after brain @entity3 resection constricts over time with greater constriction seen in @entity1 whose pre-SRS imaging is >= 1 month after initial post-operative imaging. Given that there was no difference in local recurrence rate, the data suggest  there is benefit in waiting in order to treat a smaller resection cavity.

title: Surgical Cavity Constriction and Local Progression Between Resection and Adjuvant Radiosurgery for Brain XXXX .

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['volume reduction']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['surgical cavity']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity3 :: (MESH:D009362,Disease) :: ['Metastases']


abstract: The usefulness of four spatial maze learning test methods, single T-maze, Biel water maze, Morris water maze, and radial eight-arm maze, was compared using @entity35 with different degrees of @entity4242 , which were induced by single intraperitoneal injection with 3 and 5 mg/kg of @entity7044 ( @entity7045 ) on day 13 of gestation. The single T-maze test did not detect a @entity4207 in either @entity7045 group. In the Biel water maze test, the swimming time and number of errors were increased in the 5 mg/kg group, but these parameters were comparable to the control values in the retention and path B (reverse course) tests. On the Morris water maze task, the 5 mg/kg group required longer swimming time and distance to reach the goal. In the retest with the goal set on an opposite side, the swimming distance in the 5 mg/kg group was as long as the value in the original test. The radial eight-arm maze test detected fewer correct choices in both @entity7045 groups, which showed different responses on this task. The brain weights in the 3 and 5 mg/kg groups were approximately 80 and 60% of the control value, respectively. The cerebral cortex weights were 77 and 50% of the control value, and the hippocampus weights were 78 and 51%. Among the four maze tests, only the radial eight-arm maze test could detect the effect of both doses of @entity7045 . This shows that the method has the highest sensitivity to spatial @entity4207 in @entity7045 -induced @entity20208 @entity35 .

title: Comparison of four spatial maze learning tests with @entity7044 -induced @entity4242 XXXX .

entities_list: @entity20208 :: ('MESH:C537533', 'Disease') :: ['microcephalic']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning defect']

entities_list: @entity7044 :: ('MESH:D008770', 'Chemical') :: ['methylnitrosourea']

entities_list: @entity4242 :: ('MESH:D008831', 'Disease') :: ['microcephaly']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: OBJECTIVE: To assess the incidence of arterial @entity887 in @entity1 with high rate, drug resistant, severely symptomatic paroxysmal and chronic @entity955 who have undergone atrioventricular (AV) node ablation and permanent pacing. DESIGN: Multicentre retrospective cohort study. @entity1 AND MANAGEMENT: From May 1987 to January 1997, AV node ablation was performed in 585 severely symptomatic @entity1 (mean (SD) age 66 (11) years) with high rate, drug resistant paroxysmal @entity955 (308) or chronic @entity955 (277). Lone @entity955 was present in 133 @entity1 , while the remaining 452 suffered from dilated, ischaemic, or @entity299 . @entity1 underwent VVIR (454) or DDDR (131) pacemaker implantation, after AV node ablation. Antiplatelet agents were given to 202 @entity1 , @entity1229 to 187 @entity1 . RESULTS: During a follow up of 33.6 (24.2) months, @entity1031 events were observed in 17 @entity1 (3%); the actuarial occurrence rates of @entity1031 were 1.1%, 3%, 4.2%, and 7.4% after one, three, five, and seven years, respectively. Among five variables, univariate analysis showed that only the presence of chronic @entity955 at the time of ablation (relative risk (RR) = 1.8, 95% confidence interval (CI) = 1.02 to 3. 20, p = 0.04) and the need for @entity1229 treatment (RR = 1.6, 95% CI 1.00 to 2.71, p = 0.048) were associated with a significantly higher risk of occurrence of @entity1031 events. On multivariate analysis the only predictor of @entity887 during the follow up was the presence of chronic @entity955 . CONCLUSIONS: Data from this large cohort of @entity1 indicate a fairly low incidence (1.04% per year) of @entity1031 events after AV node ablation and pacing for drug refractory, high rate @entity955 .

title: XXXX after atrioventricular node ablation and pacing: long term follow up.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolic events']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism', 'thromboembolic']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['valvar heart disease']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

answer: @entity1031 :: (MESH:D013923,Disease) :: ['Thromboembolism']


abstract: BACKGROUND: Presence of circulating @entity5 cells (CTC) in @entity1 with metastatic @entity0 is indicative for poor prognosis. An automated CTC (aCTC) algorithm developed previously to eliminate the variability in manual counting of CTC (mCTC) was used to extract morphological features. Here we validated the aCTC algorithm on CTC images from prostate, breast and @entity14 @entity1 and investigated the role of quantitative morphological parameters. METHODOLOGY: Stored images of samples from @entity1 with prostate, breast and @entity14 , healthy controls, benign breast and @entity14 were obtained using the CellSearch system. Images were analyzed for the presence of aCTC and their morphological parameters measured and correlated with survival. RESULTS: Overall survival hazard ratio was not significantly different for aCTC and mCTC. The number of CTC correlated strongest with survival, whereas CTC size, roundness and apoptosis features reached significance in univariate analysis, but not in multivariate analysis. One aCTC/7.5 ml of blood was found in 7 of 204 healthy controls and 9 of 694 @entity5 . In one @entity1 with @entity5 2 and another 9 aCTC were detected. SIGNIFICANCE OF THE STUDY: CTC can be identified and morphological features extracted by an algorithm on images stored by the CellSearch system and strongly correlate with clinical outcome in metastatic @entity0 .

title: Circulating XXXX Cells Count and Morphological Features in @entity0 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor', 'benign tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast, colorectal and prostate cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal tumors', 'colorectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Tumor']


abstract: BACKGROUND: To provide postoperative @entity1337 by spinal anesthesia, we compared the quality of @entity1337 and side effects of two doses of @entity1286 added to @entity1342 in kidney donors. MATERIALS AND METHODS: Thirty renal donors underwent nephrectomy under standard general anesthesia. After the operation, the @entity1 were randomly allocated into two groups of intrathecal doses for spinal anesthesia: the 0.5 group (n = 15) received a total volume of 4 mL including 0.5 mg @entity1286 , 10 mg @entity1342 , and 0.9% @entity1219 , and the 0.3 group (n = 15), a total volume of 4 mL including 0.3 mg @entity1286 , 10 mg @entity1342 , and 0.9% @entity1219 . After extubation, an intravenous (IV) @entity1286 protocol was initiated by a @entity1 -controlled @entity1337 pump to provide sufficient spinal @entity1337 . RESULTS: In the 0.3 group, the IV @entity1286 consumption was significantly higher, namely, 14.60 +/- 7.57 times versus 4.60 +/- 10.14 times for the 0.5 group (P = .005). The total amount of @entity1286 was 7.80 +/- 5.40 mg in the 0.5 group and 13.53 +/- 5.30 mg in the 0.3 group (P < .05). Postoperative side effects of @entity390 and @entity391 were higher among the 0.3 group (P < .05). CONCLUSIONS: In the 0.5 group, the quality of @entity1337 was better than in the 0.3 group. The need for IV @entity1286 was less in the 0.5 group. Also, side effects like @entity390 and @entity391 were less, so better @entity1337 in the postoperative period was obtained with the 0.5 mg @entity1286 solution.

title: Spinal XXXX for the postoperative period in renal donors.

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

answer: @entity1337 :: (MESH:D000699,Disease) :: ['analgesia']


abstract: BACKGROUND: To determine the influence of @entity5870 and @entity295 on @entity1904 (PCT) levels in very-low-birth-weight (VLBW) @entity1 within the first week of life. DESIGN: PCT serum levels were measured in cord blood 1 h after delivery and on day 3 and day 7 of life. @entity5870 and @entity295 within the first week were monitored. RESULTS: @entity5870 was present in eight of 37 @entity1 (21.6%). PCT on day 3 was increased in both the "No @entity5870 " (2.54 ng @entity19264 , SEM 0.51) and " @entity5870 " (6.96 ng @entity19264 , SEM 2.93) groups of VLBW @entity1 compared with the 1st hour values (0.45 and 0.58 ng @entity19264 SEM 0.07 and 0.11, respectively, P < 0.001) of the same @entity1 . The postnatal gain was higher in the " @entity5870 " group (P < 0.01). @entity295 was diagnosed (after exclusion) in 12 of 32 @entity1 (37.5%). Mean values of maximum PCT in @entity1 with and without @entity295 were 8.41 ng @entity19264 (SEM 1.87) and 3.02 ng @entity19264 (SEM 1.38), respectively (P < 0.05). Sensitivity to @entity295 of PCT, ratio of immature to total neutrophils (I : T), and @entity1851 (CRP) were 75%, 50% and 25%, respectively. CONCLUSIONS: In the group of VLBW @entity1 the PCT level within 72 h of delivery was markedly increased in @entity1 with @entity5870 . Compared with I : T and CRP, PCT appears to be a more sensitive marker of @entity295 .

title: Postnatal increase of @entity1904 in premature newborns is enhanced by XXXX and @entity295 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'Neonatal sepsis', 'neonatal sepsis']

entities_list: @entity1904 :: ('MESH:C029100', 'Chemical') :: ['procalcitonin']

entities_list: @entity5870 :: ('MESH:D002821', 'Disease') :: ['Chorioamnionitis', 'chorioamnionitis']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity5870 :: (MESH:D002821,Disease) :: ['chorioamnionitis']


abstract: Chemotherapy plus trastuzumab is the standard first-line treatment for @entity1 Epidermal Receptor 2-positive ( @entity1722 -positive) metastatic @entity0 . The aim of this international phase II trial was to determine the efficacy and safety profile of an oral chemotherapy doublet, oral @entity1206 plus @entity416 , and trastuzumab in this setting. @entity1 AND METHODS: In this single-arm, multicenter, open-label phase II study, in the first-line metastatic setting, @entity1 received 3-weekly cycles of oral @entity1206 at 80 mg/m(2) (first cycle dose 60 mg/m(2)) day 1 and day 8, plus @entity416 at 1000 (750 if >=  65 years) mg/m(2) twice daily on days 1-14, plus trastuzumab at 4 mg/kg intravenously (i.v.) on day 1 (loading dose) then 2 mg/kg i.v. weekly thereafter. Treatment was continued until progression or unacceptable @entity137 . RESULTS: Fifty @entity1 with a median age of 53.5 years were enrolled. Most (82%) had visceral involvement and 34% had more than two metastatic sites. The objective response rate (RECIST 1.0) in 44 evaluable @entity1 was 77% [95% Confidence Interval (CI)=62-89%], including complete response in 21%. The clinical benefit rate (response or stable disease for >=  6 months) was 93% [95% CI=81-99%]. Median duration of response was 13.3 [95% CI=9.8-15.7] months, median progression-free survival was 12.8 [95% CI=10.8-16.9] months and median overall survival was 47.0 [95% CI=30.5-64.3] months. Median number of cycles was 10 (range 1-81). The majority of @entity1 (72%) received more than 18 weeks and 32% more than 48 weeks of treatment. The most frequent treatment-related grade 3/4 adverse events were @entity1398 (71%), @entity8566 (20%) and @entity294 (16%). A low-rate of grade 2 alopecia was observed (14%). CONCLUSION: The triple combination of oral @entity1206 , @entity416 and trastuzumab is highly active in terms of response rate, progression-free survival and overall survival, with a manageable @entity137 profile.

title: Phase II study of a triple combination of oral XXXX , @entity416 and trastuzumab as first-line treatment in @entity1722 -positive metastatic @entity0 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'Human']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity8566 :: ('MESH:D060831', 'Disease') :: ['hand-foot syndrome']

answer: @entity1206 :: (MESH:C030852,Chemical) :: ['vinorelbine']


abstract: Six cases of a distinctive @entity2670 associated with @entity2976 were found in @entity1 13 to 76 years of age. Five @entity1 presented with abdominal swelling; on examination, three were found to have unilateral or bilateral pelvic masses, one had @entity843 and evidence of @entity1744 , and one had @entity843 alone. The sixth @entity1 presented with @entity1744 . At operation, 1 to 9 L of ascitic fluid were found in five @entity1 . Five @entity1 with bilateral @entity2670 underwent bilateral oophorectomy or, in one case, bilateral ovarian wedge resection. The sixth @entity1 had unilateral @entity2670 treated by unilateral oophorectomy. All had fibrotic thickening of the peritoneum, most prominently involving the omentum and small bowel, four at initial operation and two at a second operation performed shortly thereafter. One or more episodes of @entity1744 subsequently occurred in three of the five @entity1 with follow-up. One @entity1 died of @entity1151 2 months after her initial operation; four were alive without clinical evidence of disease 8 months to 6 years postoperatively. Gross examination revealed unilateral (one case) or bilateral (two cases), predominantly solid @entity43 12 to 31 cm in maximum dimension in three cases and slight enlargement and nodularity of both ovaries in the other three cases. Microscopic examination of the ovaries revealed a cellular proliferation of spindle cells with focal differentiation into nests of luteinized or partially luteinized cells; one case also had occasional foci of sex cord elements. The process was confined to the ovarian cortex in the three cases with slight @entity2670 . Residual ovarian follicles were entrapped by the proliferation in three cases, but were prominent in only one of them. Additional features included brisk mitotic activity, predominantly in the spindle cells, in three cases, and striking @entity4 in the three cases with significant @entity2670 . The @entity2670 were interpreted as luteinized @entity17815 , although a closely related @entity1373 with luteinization, instead of early @entity5 , cannot be excluded in the three cases with @entity2670 (and in one, prominent entrapment of follicles). The peritoneal process consisted of a variably cellular proliferation of fibroblasts and myofibroblasts separated by collagen, fibrin, and occasional chronic inflammatory cells. These cases and two similar cases from the literature suggest a unique association between some luteinized @entity17815 (or a closely related proliferative lesion of the ovary) and @entity2976 , although the relation between the ovarian and peritoneal processes is presently enigmatic.

title: @entity2976 associated with luteinized XXXX of the ovary. A clinicopathological analysis of six cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumors']

entities_list: @entity2976 :: ('MESH:D056627', 'Disease') :: ['sclerosing peritonitis']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian enlargement', 'ovarian lesions', 'ovarian lesion', 'only slight ovarian enlargement']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['small bowel obstruction']

answer: @entity17815 :: (MESH:D013798,Disease) :: ['thecomas']


abstract: The value of colour flow Doppler ultrasound scanning in @entity1 with suspected acute @entity174 has been examined. A prospective study of 78 @entity1 with signs and symptoms of @entity130 was undertaken over a period of 6 months. Both wrists of all @entity1 were scanned within 12-72 h of injury. The radial artery and carpal scaphoid bone contours are visible using this type of imaging technique. The distance between the medial wall of the radial artery and the outer cortex of the scaphoid waist was measured. The scaphoid index is described and was calculated from this measurement. @entity1 were managed without knowledge of the ultrasound imaging result, using plain radiographs and clinical examination as the standard for determining the presence of a @entity174 . All @entity1 were followed to the resolution of symptoms. All 12 @entity1 who were subsequently considered to have scaphoid @entity174 were identified using this imaging technique within 12-72 h after injury. We conclude that this imaging may be useful in the assessment of @entity1 with @entity174 . It can be used early, as a supplementary investigation, in @entity1 with suspected @entity174 in whom the initial plain radiographs are normal.

title: XXXX : a new method of assessment.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['carpal scaphoid injury']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'carpal scaphoid fracture', 'scaphoid fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Scaphoid fracture']


abstract: PURPOSE: The purpose of this study was to evaluate the clinical outcome of arthroscopic suture fixation for @entity174 in adults. METHODS: Twelve @entity1 with a mean age of 29.9 years (range, 18 to 45 years) were prospectively followed up after arthroscopic suture fixation for @entity174 . Along with clinical examination, Lysholm, Tegner, and International Knee Documentation Committee (IKDC) rating scales were used to evaluate the @entity1 . Anteroposterior knee laxity was measured with a Rolimeter (Aircast, Vista, CA), and range of motion was measured with a goniometer. RESULTS: @entity1 were followed up for a mean of 50 months (range, 25 to 69 months). There were no detectable signs or symptoms of instability postoperatively. The mean preinjury Tegner score was 6.1 (range, 3 to 9), and at follow-up, the mean Tegner score was 5.8 (range, 3 to 9). No Lysholm or IKDC scores were obtained and no range-of-motion measurements were performed preoperatively because all injuries were acute. The mean Lysholm score was 98 (range, 94 to 100), and the mean IKDC score was 94.7 (range, 89.1 to 100). Anterior translation of the tibia, measured with the Rolimeter, was 0.58 mm on average (range, 0 to 3 mm) compared with the healthy side. Postoperatively, the mean extension deficit was 1   (range, 0   to 5  ) and the mean flexion deficit was 2.7   (range, 0   to 10  ) compared with the unaffected side. Overall, knees were graded as normal or nearly normal in 11 @entity1 and abnormal in 1. CONCLUSIONS: Tibial eminence @entity174 in adults can be effectively treated with arthroscopic suture fixation. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

title: Clinical outcome of arthroscopic suture fixation for XXXX in adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['tibial eminence fractures', 'fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['tibial eminence fractures']


abstract: UNASSIGNED: @entity9 is a frequent complication of @entity1566 ( @entity1566 ), still refractory to conventional treatment. The presence and biological activity of steroidogenic regulatory proteins and enzymes in the spinal cord suggests that neurosteroids locally generated could modulate @entity158 messages. In this study we explored temporal changes in the spinal expression of the 18kDa translocator protein @entity27042 , the steroidogenic acute regulatory protein (StAr) and the steroidogenic enzyme 5a-reductase (5a-RI/II) in an experimental model of central @entity1118 . Male @entity35 were subjected to a @entity1566 and sacrificed at different time points (1, 14 or 28 days). The development of mechanical and cold @entity1931 was assessed. Injured animals showed an early increase in the mRNA levels of @entity27042 and 5a-RII, whereas in the chronic phase a significant decrease in the expression of 5a-RI and 5a-RII was observed, coinciding with the presence of @entity146 . Furthermore, since we have shown that @entity1420 ( @entity22517 ) administration may offer a promising perspective in @entity158 modulation, we also evaluated the expression of steroidogenic proteins and enzymes in injured animals receiving daily injections of the @entity479 . @entity22517 -treated did not develop @entity1931 and showed a marked increase in the mRNA levels of @entity27042 , StAR, 5a-RI and 5a-RII 28days after injury. Our results suggest that in the acute phase after @entity1566 , the increased expression of @entity27042 and 5a-RII may represent a protective endogenous response against @entity3145 , which is not maintained in the chronic allodynic phase. @entity22517 may favor local steroidogenesis and the production of its reduced metabolites, which could contribute to the antiallodynic effects observed after @entity22517 treatment.

title: Temporal changes in the expression of the translocator protein @entity27042 and the steroidogenic enzyme 5a-reductase in the dorsal spinal cord of animals with @entity9 : effects of XXXX administration.

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['allodynic behaviors']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue injury']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['Neuropathic pain']

answer: @entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']


abstract: BACKGROUND: Data on the effect of revascularization on outcome in @entity1 with high-risk non-ST-segment elevation @entity1187 (NSTEACS) and significant comorbidities are scarce. Recently, a simple comorbidity index (SCI) including 5 comorbidities ( @entity177 , @entity303 , @entity3657 disease, @entity712 , and prior @entity583 [ @entity583 ]) has shown to be a useful tool for risk stratification. Nevertheless, therapeutic implications have not been derived. HYPOTHESIS: We sought to evaluate the prognostic effect attributable to revascularization in NSTEACS according the SCI score. METHODS: We included 1017 consecutive @entity1 with NSTEACS. The effect of revascularization on a combined end point of all-cause mortality or nonfatal @entity583 was evaluated by @entity797 regression according to SCI categories. RESULTS: A total of 560 (55.1%), 236 (23.2%), and 221 (21.7%) @entity1 showed 0, 1, and >= 2 points according to the SCI, respectively. Coronary angiography was performed in 725 @entity1 (71.5%), and 450 @entity1 (44.3%) underwent revascularization. During a median follow-up of 16 months (interquartile range, 12-36 months), 305 (30%) @entity1 experienced the combined end point (202 deaths [19.9%] and 170 MIs [16.7%]). In multivariate analysis, a differential prognostic effect of revascularization was observed comparing SCI >= 2 vs 0 (P for interaction = 0.008). Thus, revascularization was associated with a greater prognostic benefit in @entity1 with SCI >= 2 (hazard ratio [HR]: 0.51, 95% confidence interval [CI]: 0.29-0.89), P = 0.018), whereas no significant benefit was observed in those with 0 and 1 point (HR: 1.31, 95% CI: 0.88-1.94, P = 0.171 and HR: 1.11, 95% CI: 0.70-1.76, P = 0.651, respectively). CONCLUSIONS: In NSTEACS, the SCI score appears to be a useful tool for identifying a subset of @entity1 with a significant long-term death/ @entity583 risk reduction attributable to revascularization.

title: Differential prognostic effect of revascularization according to a simple comorbidity index in high-risk non-ST-segment elevation XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

answer: @entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']


abstract: BACKGROUND: @entity440 is effective in treating @entity0 , reduces @entity0 incidence among high-risk @entity1 , and is associated with increased @entity1204 risk. This study was designed to examine the possible modifying effects of @entity1204 risk factors on the @entity440 - @entity1204 association. METHODS: We conducted a case-control study of @entity1204 (324 case @entity1 and 671 individually matched control subjects) nested within a population-based cohort of @entity1 with @entity0 diagnosed from 1978 through 1992 within four regions of the United States. We obtained information on @entity0 treatment and @entity1204 risk factors through interviews and reviews of medical records. All P values reported are two-sided. RESULTS: @entity1204 risk was associated with @entity440 therapy for @entity0 (odds ratio = 1.52; 95% confidence interval [CI] = 1. 07-2.17). Risk increased with duration of @entity440 use (P for trend =.0002). @entity1 with more than 5 years of exposure to @entity440 had 4. 06-fold greater odds of developing @entity1204 than nonusers (95% CI = 1.74-9.47). Prior use of @entity172 replacement therapy (ERT) increased risk associated with @entity440 use (P for homogeneity of trends <.0001). Risk associated with @entity440 use was stronger among heavier @entity1 than among thinner @entity1 , although trends did not differ statistically (P =.10). @entity440 dose-response effects were more pronounced among @entity1 with both previous ERT exposure and higher body mass index than among @entity1 in other risk groups. CONCLUSIONS: ERT use and @entity28 , both established @entity1204 risk factors and markers of @entity172 exposure, substantially modify the association between @entity440 use and @entity1204 risk among @entity1 with @entity0 . @entity1 with positive ERT histories and those who are obese, when prescribed @entity440 , may warrant closer surveillance for @entity1204 than @entity1 without such histories.

title: XXXX therapy for @entity0 and @entity1204 risk.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'Endometrial cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen', 'Tamoxifen']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity440 :: (MESH:D013629,Chemical) :: ['Tamoxifen']


abstract: A total of 220 @entity880 bacteria isolates were screened for antifungal activity using @entity54 and @entity11150 as the target strains. Four Lactobacillus strains exhibited strong inhibitory activity on agar surfaces. All four were also identified as having strong inhibitory activity against the @entity1 pathogenic fungi @entity14476 , @entity14955 and @entity15528 . One of the four lactobacilli, namely Lb. reuteri ee1p exhibited the most inhibition against dermatophytes. Cell-free culture supernatants of Lb. reuteri ee1p and of the non-antifungal Lb. reuteri M13 were freeze-dried and used to access and compare antifungal activity in agar plate assays and microtiter plate assays. Addition of the Lb. reuteri ee1p freeze-dried cell-free supernatant powder into the agar medium at concentrations greater than 2% inhibited all fungal colony growth. Addition of the powder at 5% to liquid cultures caused complete inhibition of fungal growth on the basis of turbidity. Freeze-dried supernatant of the non-antifungal Lb. reuteri M13 at the same concentrations had a much lesser effect. As Lb. reuteri M13 is very similar to the antifungal strain ee1p in terms of growth rate and final pH in liquid culture, and as it has little antifungal activity, it is clear that other antifungal compounds must be specifically produced (or produced at higher levels) by the anti-dermatophyte strain Lb. reuteri ee1p. @entity48400 was undetectable in all four antifungal strains. The cell free supernatant of Lb. reuteri ee1p was analyzed by LC-FTMS using an Accela LC coupled to an LTQ Orbitrap XL mass spectrometer. The high mass accuracy spectrum produced by compounds in the Lb. reuteri ee1p strain was compared with both a multianalyte chromatogram and individual spectra of standard anti-fungal compounds, which are known to be produced by @entity880 bacteria. Ten antifungal metabolites were detected.

title: Antifungal activity of Lactobacillus against @entity14476 , @entity14955 and XXXX .

entities_list: @entity14955 :: ('63402', 'Species') :: ['Microsporum gypseum']

entities_list: @entity11150 :: ('5061', 'Species') :: ['Aspergillus niger']

entities_list: @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

entities_list: @entity14476 :: ('63405', 'Species') :: ['Microsporum canis']

entities_list: @entity15528 :: ('34391', 'Species') :: ['Epidermophyton floccosum']

answer: @entity15528 :: (34391,Species) :: ['Epidermophyton floccosum']


abstract: In the present study, we constructed a left ventricular pressure-volume loop from catheterization data and RN-angiocardiography. By connecting the point of origin of the plane, not the point of Vd, with the end-systolic point of the loop, we calculated a "systolic" pressure-volume area ( @entity939 ), elastic potential energy (EPE), and @entity64 work (SW). @entity998 (CO)-pulmonary artery wedge (PAW) pressure plot was constructed at rest and during exercise, using a bicycle ergometer, to evaluate cardiac pump function. End-systolic volume ( @entity5778 ) was obtained from the left ventricular P-V loop, and the response of @entity5778 to exercise was investigated. Thirty-five @entity1 with various @entity299 were categorized in two groups according to the delta CO/delta PAW obtained from the shift of the CO-PAW plot during exercise; group I (n = 28) with the properly functioning hearts having the ratio greater than 0.12 l/min/mmHg and group II (n = 7) with the poorly functioning hearts having the ratio less than or equal to 0.12 l/min/mmHg. Group I was subdivided further into two subsets according to the changing pattern of @entity5778 during exercise; group I-A with decreased or unchanged @entity5778 (n = 20) and group I-B with increased @entity5778 in which end-diastolic volume (EDV) was increased during exercise (n = 8). During exercise, @entity939 and SW were unchanged but SW/ @entity939 increased in group I-A, suggesting improvement of external mechanical efficiency. SW/ @entity939 was unchanged in group I-B, despite the increase in @entity939 and SW. This suggested that external mechanical work increased as a result of increased cardiac @entity26 consumption. In group II, @entity939 increased, SW was unchanged and SW/ @entity939 decreased, which could be explained by the mechanism that external mechanical work during exercise decreased as compared with that at rest. It was suggested that a different mechanism may have been responsible for the production of external mechanical work among @entity1 in group I-A and in group I-B with properly functioning hearts judged from the CO-PAW plot. Therefore, it seems useful to calculate @entity939 , SW and SW/ @entity939 during exercise using the left ventricular pressure-volume loop for evaluating cardiac function.

title: [Response of cardiac XXXX to dynamic exercise: analysis with "systolic" pressure-volume area].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['A cardiac output']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Chemical and radiological @entity137 related to @entity595 acute exposure have been widely studied in nuclear fuel workers and military personnel. It is well known that @entity7524 induces @entity810 ( @entity810 ). However, the mechanisms of this metal-induced injury are not well defined at the molecular level. RESULTS: Renal function and histology were assessed in @entity19 receiving @entity7524 (UN(+)) and controls (UN(-)). To identify the genomic response to @entity595 exposure, serial analysis gene expression (SAGE) of the kidney was performed in both groups. Over 43,000 mRNA SAGE tags were sequenced. A selection of the differentially expressed transcripts was confirmed by real-time quantitative PCR and Western blotting. UN(+) animals developed @entity177 and displayed the characteristic histological lesions of UN @entity8 . Of the >14,500 unique tags identified in both libraries, 224 had a modified expression level; they are known to participate in @entity32 , ion transport, signal transduction, oxidative stress, apoptosis, metabolism, and catabolism. Several genes that were identified had not previously been evaluated within the context of toxic @entity810 such as translationally controlled @entity5 protein, @entity45404 and @entity45405 , all apoptosis related genes. CONCLUSION: We report a comprehensive description of the UN induced modifications in gene expression levels, including the identification of genes previously unrelated to @entity810 . The study of these genes and the metabolisms they control should improve our understanding of toxic @entity810 and enlighten on the molecular targets for potential therapeutic interventions.

title: Comprehensive analysis of the renal transcriptional response to acute XXXX exposure.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity45404 :: ('29817(Tax:10090)', 'Gene') :: ['insulin like growth factor binding protein 7']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['ARF', 'acute renal failure']

entities_list: @entity595 :: ('MESH:D014501', 'Chemical') :: ['uranium']

entities_list: @entity7524 :: ('MESH:D014502', 'Chemical') :: ['uranyl nitrate']

answer: @entity7524 :: (MESH:D014502,Chemical) :: ['uranyl nitrate']


abstract: The efficacy of epidural @entity10541 and @entity1341 , combined with @entity3575 to enhance blockade, was compared in two parallel controlled, double-blind clinical trials. @entity1 in the studies (n = 91) were scheduled for orthopedic surgery of the legs and a tourniquet was used in all cases. Those @entity1 receiving @entity10541 attended day surgery only, whereas @entity1 receiving @entity1341 were hospitalised. Epidural puncture was performed with a Tuohy needle at the @entity6357 level in the lateral decubitus position. Levels of sensory and motor blockade were assessed; adverse reactions and @entity158 during surgery were recorded. There were four groups of @entity1 : 1) 26 received 2% @entity10541 with placebo; 2) 26 received 2% @entity10541 with 0.1 mg @entity3575 ; 3) 19 received 0.5% @entity1341 with placebo and 4) 20 @entity1 received 0.5% @entity1341 with 0.1 mg @entity3575 . The levels of the sensory blockade was comparable in all groups. The degree of motor-blockade was more intense in the @entity10541 groups, but the blockade by @entity10541 lasted shorter. Addition of @entity3575 did not change the sensory and motor blockade. Intraoperative @entity158 was reported by: 7 @entity1 in the @entity10541 /placebo group; 4 @entity1 in the @entity10541 / @entity3575 group; 4 @entity1 in the @entity1341 /placebo group; and by one @entity1 in the @entity1341 / @entity3575 group. These results indicate that @entity3575 enhances the quality of epidural blockade when combined with either @entity10541 or @entity1341 .

title: @entity3575 in 2% @entity10541 compared with @entity3575 in 0.5% XXXX : two parallel controlled double blind studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity10541 :: ('MESH:D008619', 'Chemical') :: ['mepivacaine']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']