abstract: BACKGROUND: Chronic rhinosinusitis has a major impact on the quality of life of @entity1 with @entity1577 ( @entity1577 ) and may contribute to progression of @entity1030 . Despite multiple sinus surgeries, maxillary sinus involvement is a recurrent problem. The @entity3517 ( @entity3517 ) permits debridement in the clinic, improves mucus clearance with nasal irrigations, and increases access for topical delivery of therapeutics. However, clinical outcomes of aggressive sinus surgery with regimented postoperative medical treatment have not been systematically evaluated. METHODS: @entity1577 @entity1 completed the 22-Item Sinonasal Outcome Test questionnaires before sinus surgery (and bilateral @entity3517 ) and at sequential postoperative visits. Objective measures included Lund-Kennedy endoscopic score and pulmonary function tests (forced expiratory volume at 1 second percent [FEV(1)%] predicted). Culture-directed antibiotic therapy, @entity229 , and topical irrigations were initiated postoperatively. RESULTS: Twenty-two @entity1 (mean age, 26.5 years; 4.9 prior sinus operations) underwent @entity3517 and sinus surgery. Symptom scores were significantly reduced at 60 days (primary outcome, 64.7    18.4 presurgery versus 27.5    15.3 postsurgery; p < 0.0001) and up to a year postoperatively (27.6    12.6; p < 0.0001). Endoscopic scores were also reduced after surgery (10.4    1.1 presurgery versus 5.7    2.4 [30 days], 5.7    1.4 [60 days], 5.8    1.3 [120 days], and 6.0    1.1 [1 year]; p < 0.0001)]. There were no differences in FEV(1)% predicted up to 1 year postoperatively, but hospital admissions secondary to pulmonary exacerbations significantly decreased (2.0    1.4 versus 3.2    2.4, respectively; p < 0.05). CONCLUSION: Prospective evaluation indicates sinus surgery with @entity3517 is associated with marked improvement in sinus disease outcomes. Additional studies are necessary to confirm whether this treatment paradigm is associated with improved @entity3794 .

title: Extensive surgical and comprehensive postoperative medical management for XXXX chronic rhinosinusitis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3517 :: ('MESH:C564098', 'Disease') :: ['MEMM', 'modified endoscopic medial maxillectomy']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['CF pulmonary disease']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic lung disease']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis']

answer: @entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']


abstract: PURPOSE: This phase II trial was designed to evaluate the feasibility, @entity137 , response rates, and survival for neoadjuvant chemotherapy and radiotherapy (RT) followed by surgical resection in newly diagnosed @entity1 with surgically staged IIIA @entity1149 ( @entity1149 ). @entity1 AND METHODS: Previously untreated @entity1 with @entity1149 underwent bronchoscopy, chest and abdominal computed tomography (CT), bone scan, and surgical staging of the mediastinum. Neoadjuvant treatment consisted of concurrent chemotherapy and RT. @entity1 then underwent surgical resection, which was followed in turn by additional chemotherapy and RT. Chemotherapy included @entity900 100 mg/m2 on days 1 and 29, @entity5713 3 mg/m2 on days 1 and 3 and 29 and 31, and @entity1487 ( @entity1487 ) 30 mg/kg/d by infusion on days 1 to 3 and 29 to 31 (FVP). RT began on day 1 and included 3,000 cGy in 15 fractions. Surgery took place on day 55, and one more cycle of chemotherapy and an additional 3,000 cGy of RT began on day 85. RESULTS: Forty-one eligible @entity1 (median follow-up, 53 months) were studied. N2 disease was present in 80%, whereas 20% had T3N0 or T3N1 lesions. Response to neoadjuvant chemotherapy and RT included no complete responses (CR), 21 (51%) partial responses (PR) or regressions, 19 (46%) @entity66 ( @entity66 ), and one (2%) @entity74 ( @entity74 ). Thirty-one @entity1 underwent surgery, and 25 were resected. In four of the 25 resection specimens, no viable @entity5 was present, whereas in three of the six unresectable @entity1 , extensive biopsy results demonstrated only @entity5 . The maximum response achieved using all protocol treatment was 27 (66%) CRs, seven (17%) PRs or regression, six (15%) SDs, and one (2%) @entity74 . @entity137 was substantial and primarily hematologic. There were six (15%) treatment-related @entity204 , which included three perioperative @entity204 and three chemotherapy-related @entity137 @entity204 . The Kaplan-Meier curve indicated a 1-year survival of 58% and a median survival of 15.5 months. Nine @entity1 (22%) remain disease-free. CONCLUSIONS: There was a reasonably high rate of PR associated with concurrent neoadjuvant chemotherapy and RT, and a high percentage of @entity1 who ultimately were rendered completely disease-free. However, treatment-related morbidity and mortality was common. Median survival seemed to be only modestly improved beyond that achieved with less intensive means of treatment. However, a group has emerged of @entity1 who enjoy prolonged disease-free survival and possible cure.

title: Neoadjuvant chemotherapy and radiotherapy followed by surgery in stage IIIA non-small-cell carcinoma of the lung: report of a XXXX and Leukemia Group B phase II study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['stable disease', 'SD']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'necrotic tumor']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung carcinoma']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', 'fluorouracil']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['PD', 'progressive disease']

entities_list: @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: @entity1358 ( @entity1358 ) is a rare, low-grade @entity5 with clear cells and hyalinized stroma. Prognosis of @entity1358 is excellent with few cases metastasizing to the lymph nodes and lung. We present a case of a 61-year-old male with recurrent @entity1358 on the base of tongue. Histologic examination revealed sheets of clear and eosinophilic cells with a background of a myxoid-like matrix. In addition, large, bizarre malignant cells, focal @entity39 , and atypical mitotic figures were identified. By immunohistochemistry, the clear cells were positive for @entity2873 , EMA and @entity2277 , focally positive for @entity5822 and @entity2282 , but negative for @entity4206 , @entity13474 , @entity4574 and calponin. A metastatic @entity1358 was considered a possibility but the @entity5 was called "poorly-differentiated @entity189 , NOS". The @entity1 underwent primary radiotherapy. A recurrence was identified at 10  months follow-up. A biopsy of the recurrent @entity5 showed clear cell differentiation and a predominant cribriform pattern with focal cords of eosinophilic cells invading the stroma. In contrast to the original @entity5 , no mitotic figures, atypia or @entity39 were identified. The combination of lower grade and different architectural patterns appeared markedly different than the previous biopsy and the immunohistochemical pattern was also different. The recurrent @entity5 showed diffuse positivity for @entity4206 and @entity13474 . It was negative for @entity2282 , @entity2277 , @entity4574 and calponin. Fluorescence in situ hybridization (FISH) analysis was positive for rearrangement of the @entity12726 gene in both samples, confirming that this represented a recurrence of the same @entity5 . It also confirmed that the initial @entity5 was a @entity1358 with high-grade transformation.

title: Recurrent XXXX of the base of tongue with high-grade transformation and @entity12726 gene rearrangement by FISH.

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['salivary gland tumor', 'tumor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'Hyalinizing clear cell carcinoma', 'HCCC']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['hyalinizing clear cell carcinoma']


abstract: @entity4368 ( @entity4368 ) is an area of poorly mineralized dentine matrix. It has been reported that there is an association between the retraction of odontoblast processes (OP) and the formation of @entity4368 . A variation of the extent of OP has been described depending on the region of the tooth and age. This study aimed to find out the regional distribution of @entity4368 in @entity1 teeth to observe any association between the extent of OP and the pattern of distribution of @entity4368 . Ground sections were prepared from 52 extracted permanent teeth and the presence of @entity4368 was observed in different regions of the crown and the root. The highest occurrence of @entity4368 was found in the cervical and middle thirds followed by intercuspal, and coronal third in the crown. Statistical analysis of data depicted that the occurrence of @entity4368 differed according to the region of the tooth. In roots, the highest occurrence of @entity4368 was seen in the cervical third followed by the middle third. Previous reports have shown that OP extend up to the dentine-enamel junction in the coronal region and to the inner one-third of the cervical region. The varied pattern of distribution of @entity4368 in the crown and root observed in our results corresponds to the above findings. Therefore, it is reasonable to surmise that there is an association between the distribution of @entity4368 and the extent of OP. This allows us to confer that @entity4368 tends to form in areas where OP do not extend to the dentine-enamel junction.

title: Regional distribution of interglobular dentine in XXXX teeth.

entities_list: @entity4368 :: ('MESH:D003805', 'Disease') :: ['IGD', 'Interglobular dentine']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The purpose of this study was to investigate the effect of dietary @entity270 and @entity620 , probiotics mixture and protein level and their combination on semen quality and immunohistochemical study of some pituitary hormones in male broiler breeders. One hundred and eighty male broiler breeders 65 weeks old were divided into six groups by completely randomized design. The birds were subjected to @entity219 -induced molt by mixing @entity1947 at the rate of 3000mg/kg in the feed. After molting, one group was fed control diet (CP16%). The other groups were fed @entity270 (100IU/kg), @entity620 (500IU/kg), probiotics (50mg/L of drinking water), protein ( @entity28793 %) and combination of these components. These treatments were given for five weeks. After the feeding period, semen samples were taken and analyzed for semen volume, sperm concentration, motility and dead sperm percentage. Pituitary samples were collected from three birds per replicate and were processed for immunohistochemical study. The results of semen quality parameters revealed that semen volume and sperm motility were significantly high in the @entity270 fed group, while the dead sperm percentage decreased significantly in the @entity620 group. The morphometric analysis revealed that compared to other groups, @entity270 caused a significant increase in the size and area of FSH, LH gonadotropes and lactotropes. These results showed that @entity270 alone may play some role in the enhancement of semen quality and growth of gonadotropes and lactotropes.

title: Supplementation of dietary vitamins, protein and probiotics on semen traits and immunohistochemical study of pituitary hormones in XXXX -induced molted broiler breeders.

entities_list: @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E']

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C']

entities_list: @entity1947 :: ('MESH:D015034', 'Chemical') :: ['zinc oxide']

answer: @entity219 :: (MESH:D015032,Chemical) :: ['zinc']


abstract: @entity4328 tRNA genes can be expressed efficiently in vivo in @entity375 , and transcription products are processed to mature tRNAs. However, primary transcripts of a variant tRNA( @entity2596 )(UAC) gene are processing deficient under standard growth conditions (30 degrees C), due to a slightly altered 5' flanking region. A stable extended @entity535 acceptor stem, which seems to be required to compensate a G5-G68 mismatch, cannot form. This mismatch destabilizes secondary and probably tertiary structures to such an extent that recognition of processing enzyme(s) under normal conditions (30 degrees C) is impaired. Growing @entity375 cells at reduced temperature (22 degrees C) can phenotypically complement the processing defect. This observation provides a new concept for the temperature dependent expression of protein coding genes which carry a nonsense codon. Translation of corresponding messages can be controlled by products of a temperature sensitive su-tRNA gene. We successfully tested this concept with two amber suppressors derived from a tRNA( @entity367 )(UUC) gene from @entity4328 . One of the variant tRNA genes codes for a product with a destabilized @entity535 acceptor stem. Primary transcripts of this particular su-tRNA( @entity367 )(CUA) gene are processed only at reduced growth temperatures and consequently function as temperature sensitive suppressors only under these conditions.

title: Temperature sensitive synthesis of transfer RNAs in vivo in XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity4328 :: ('44689', 'Species') :: ['D. discoideum', 'Dictyostelium discoideum']

answer: @entity375 :: (4932,Species) :: ['Saccharomyces cerevisiae']


abstract: BACKGROUND: @entity12767 ( @entity12767 ) are continually exposed to hazards from contact with blood and body fluids of @entity1 in the healthcare setting. AIM: To determine the prevalence of @entity2949 ( @entity2949 ) and associated factors among @entity12767 in the Accident and Emergency Department of the University of Benin Teaching Hospital (UBTH), Benin City, Nigeria. SUBJECTS AND METHODS: This was a cross-sectional study. Data were collected using a structured, self-administered questionnaire and analyzed using IBM SPSS version 20. Univariate, bivariate, and binary logistic regression analyses were done. The level of significance was set at P < 0.05. RESULTS: The prevalence of @entity2949 12 months preceding the study was 51.0% (50/98). Doctors 8/10 (80.0%) and nurses 28/40 (70.0%) had the highest occurrence. Recapping of needles 19/50 (38.0%) and @entity1 aggression 13/50 (26.0%) were responsible for most injuries. The majority 31/50 (62.0%) of the injuries were not reported. The uptake of postexposure prophylaxis (PEP) was low 11/50 (22.0%). The factors that were significantly associated with NSI include age 30 years and above (odds ratio [OR] =0.28, confidence interval [CI] = 0.11-0.70), work duration of three years and above (OR = 0.29, CI = 0.11-0.75), and being a nurse (OR = 3.38, CI = 1.49-9.93) or a paramedic (OR = 0.18, CI = 0.06-0.52). CONCLUSION: The high prevalence of @entity2949 among the @entity12767 , especially in doctors and nurses is an indication that @entity12767 in UBTH are at great risk of contracting @entity1503 . Efforts should be made to ensure that injuries are reported and appropriate PEP undertaken following @entity2949 .

title: Prevalence of XXXX Among Healthcare Workers in the Accident and Emergency Department of a Teaching Hospital in Nigeria.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity12767 :: ('MESH:D000382', 'Disease') :: ['HCWs', 'Healthcare workers']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood-borne infections']

entities_list: @entity2949 :: ('MESH:D016602', 'Disease') :: ['needlestick injuries', 'NSIs']

answer: @entity2949 :: (MESH:D016602,Disease) :: ['Needlestick Injuries']


abstract: BACKGROUND: Biorepository research has substantial societal benefits. This is one of the few studies to focus on male willingness to allow future research use of biospecimens. METHODS: This study analyzed the future research consent questions from a @entity263 biorepository study (N  =  1931). The consent form asked two questions regarding use of samples in future studies (1) without and (2) with protected health information (PHI). Yes to both questions of use of samples was categorized as Yes-Always; Yes to without and No to with PHI was categorized as Yes-Conditional; No to without PHI was categorized as Never. We analyzed this outcome to determine significant predictors for consent to Yes-Always vs. Yes-Conditional. RESULTS: 99.33  % consented to future use of samples; 88.19  % consented to future use without PHI, and among those @entity1 10.2  % consented to future use with PHI. Comparing Yes Always and Yes Conditional responses, bivariate analyses showed that race, family history, stage of @entity5 , and grade of @entity5 (Gleason), were significant at the a  =  0.05 level. Using stepwise multivariable logistic regression, we found that African-American @entity1 were significantly more likely to respond Yes Always when compared to White @entity1 (p  <  0.001). Those with a family history of @entity263 were significantly more likely to respond Yes Always (p  =  0.002). CONCLUSIONS: There is general willingness to consent to future use of specimens without PHI among @entity1 .

title: Secondary consent to biospecimen use in a XXXX biorepository.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: STUDY OBJECTIVE: To estimate the effect of body mass index (BMI) on several outcomes in laparoscopic hysterectomy, in particular in the extremes of @entity28 . DESIGN: Retrospective cohort study (Canadian Task Force classification II-3). SETTING: Tertiary-care university-based teaching hospital. @entity1 : Eight hundred thirty-four @entity1 who underwent laparoscopic hysterectomy from January 2007 to October 2011. INTERVENTION: Laparoscopic hysterectomy for benign indications. MEASUREMENTS AND MAIN RESULTS: Demographic, operative, and postoperative data were abstracted from medical records. The primary outcome was a composite index score that took into account operative time, nonsurgical operating room time, estimated @entity190 , length of hospital stay, number of complications, and severity of complications according to the Dindo-Clavien classification. We individually examined elements of the composite index as a secondary outcome. Models were developed to assess the association of BMI with the composite index score and the components of the index, controlling for age, presence of @entity6 , @entity286 use, surgeon, type of hysterectomy (total vs supracervical), use of robotics, uterine weight, number of additional procedures performed, presence of adhesions requiring lysis, and deeply infiltrating @entity46 as potential confounders. Mean (SD) BMI was 31.4 (8.1). Mean (SD) uterine weight was 345 (388) g. Mean operative time was 150 (61) minutes. Increasing BMI was associated with a worse composite score (p < .01); longer operative time (p = .03), nonsurgical operating room time (p = .02), and total operating room time (p < .01); greater estimated @entity190 (p < .01); and complication severity (p = .01). CONCLUSION: These data suggest that there is a significant association of BMI with surgical outcomes in laparoscopic hysterectomy, and the effect is most pronounced in the morbidly @entity28 . These @entity1 may stand to gain the greatest differential benefit from a laparoscopic approach to surgery. However, they should be properly counseled about the challenge that @entity28 poses to the operation.

title: Effect of extreme XXXX on outcomes in laparoscopic hysterectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: PURPOSE: To evaluate the efficacy and the @entity137 of 0.15% @entity4540 gel in the treatment of @entity2024 and in preventing @entity2194 after @entity2024 , such as corneal infiltrates and @entity8307 . METHODS: Double blind, interventional and randomized clinical trial. Thirty-three @entity1 with clinical diagnosis of @entity2024 with onset of symptoms for five or less days were randomized in two groups: Group 1 (treatment) with 19 @entity1 used @entity4540 gel and Group 2 (control) with 14 @entity1 used artificial tears without preservative. @entity1 answered a questionnaire of signs and symptoms and were submitted to an ophthalmologic exam. On the 6th and 10th days of treatment they answered the same questions and were re-examined by the same ophthalmologist. Signs and symptoms were compared. T Student, Mann-Whitney e Wilcoxon tests were used to statistical analysis. RESULTS: Trend of better response in the treatment group in relation of @entity1 ' perception, besides faster improvement of this group compared to the control group (p=0.26). There were lower transmission to the fellow eye (p=0.86) and to @entity1 living together (p=0.16) in the treatment group. No statistical difference related to signs and symptoms of @entity2024 were found comparing both groups. We observed statistical difference in @entity158 , itch and @entity3917 only in the treatment group, comparing each group alone. No @entity137 and more tolerance of the @entity4540 were observed. There was no statistical difference in the @entity2194 after @entity2024 between both groups. CONCLUSIONS: This study showed trend of better and faster response of the signs and symptoms of the @entity1 treated with @entity4540 compared with the control group, but with no statistical significant. These results need to be confirmed by additional studies, with more @entity1 and longer follow-up. Clinical Trails.gov: NCT01349452.

title: [ XXXX 0.15% ophthalmic gel in the treatment of adenovirus keratoconjunctivitis].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'people']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular complications']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity8307 :: ('MESH:D004761', 'Disease') :: ['pseudomembranes']

entities_list: @entity2024 :: ('MESH:D003231', 'Disease') :: ['adenoviral conjunctivitis', 'conjunctivitis']

entities_list: @entity4540 :: ('MESH:D015774', 'Chemical') :: ['ganciclovir']

entities_list: @entity3917 :: ('MESH:D020795', 'Disease') :: ['photophobia']

answer: @entity4540 :: (MESH:D015774,Chemical) :: ['Ganciclovir']


abstract: A disease of @entity291 characterized by swelling of the vulva, acute @entity32 of the vaginal mucosa, accompanied by a more or less profuse mucopurulent exudate is described. After the acute @entity32 subsides the mucosa becomes studded with tiny, round, raised, red nodules which persist 2 or 3 months or longer. The acute lesion consists in @entity39 of the epithelium and accumulations of leucocytes and round cells in the @entity4 submucosa. The nodules in the later stages are made up of densely packed masses of lymphocytes in the submucosa which force the epithelial layer outward. A Gram-negative bacillus with tiny polar granules was found in the exudate. It measures I to 2micro in length and stains with difficulty. The organism was obtained in pure culture by inoculating the exudate into tubes of slanted agar to which defibrinated @entity1641 blood had been added. Growth occurs only in sealed tubes. The organism possesses slight pathogenicity for @entity840 . When freshly isolated cultures were introduced into the vagina of heifers or young @entity291 , acute @entity32 resulted which terminated in the characteristic granular stage of the disease.

title: AN INFECTIOUS GRANULAR VAGINITIS OF XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['edematous']

answer: @entity291 :: (9913,Species) :: ['COWS']


abstract: PURPOSE: The purpose of this study was to examine @entity147 , alexithymia, and coping styles as predictors of cardiac rehabilitation (CR) outcomes and attendance. METHODS: @entity1 included 56 @entity1 in an outpatient CR program (65% male, 59% white, M = 61.1 years) who completed self-report measures of @entity147 (ie, @entity308 and @entity148 ), alexithymia, and coping styles (ie, approach and avoidance coping). CR outcomes recorded at entry and completion of the program included blood @entity165 , @entity26 uptake ((Equation is included in full-text article.)VO(2max)), knowledge about @entity299 , and self-reported lipid consumption. Attendance was also recorded as a measure of adherence. RESULTS: Significant improvements were observed in @entity26 uptake, high-density lipoprotein levels, disease knowledge, and self-reported lipid consumption. Older age was associated with less distress, and @entity148 and higher education were associated with better attendance. Higher alexithymia (ie, greater difficulty processing emotion) was associated with increased low-density lipoprotein @entity165 , and alexithymia predicted increased self-reported lipid consumption in the context of higher approach coping. CONCLUSIONS: CR is associated with physical and quality-of-life benefits, as well as increased knowledge about @entity299 management. However, coping strategies that are generally beneficial (approach coping) may be associated with negative health behavior among individuals who have difficulty processing emotion. @entity148 and lower education were associated with poorer attendance, perhaps indicating the need for intervention to prevent dropout.

title: XXXX , alexithymia, and coping as predictors of cardiac rehabilitation outcomes and attendance.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity147 :: ('MESH:D005316', 'Disease') :: ['emotional distress']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'Anxiety', 'anxiety']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity147 :: (MESH:D005316,Disease) :: ['Emotional distress']


abstract: OBJECTIVE: To explore the clinical and pathological features of @entity3169 and @entity3291 . METHODS: It was a retrospective case series study. The clinical and pathological features of 3 cases of @entity3169 and 2 cases of @entity3169 were analyzed. These cases were treated from January 2005 to December 2010 at Tianjin Eye Hospital. Routine pathological examinations and immunohistochemical staining were performed, including staining for @entity2277 , @entity4483 , @entity11280 and @entity2280 . RESULTS: In the 5 @entity1 , 2 cases were male and 3 cases were female. The mean age was (55.8    14.8) years, ranging from 40 to 74 years. The @entity5 presented as yellow-pink, translucent, cystic and(or) with solid masses. Regarding the @entity5 location, 2 cases involved the temporal side, 1 case involved the nasal side, 1 case involved the nasal limbus and invaded the @entity267 , and 1 case involved the nasal, temporal and inferior parts. The lesions of the 5 cases were excised under local anaesthesia. Histopathological examination revealed that the conjunctival @entity3291 were composed of abundant mucoid material and relatively small numbers of small, ovoid, spindle and stellate shaped cells with sparse vessels. The histologic features of the @entity3169 were similar to those of @entity3291 with the exception of the former being characterized by a prominent vascular structure. The immunohistochemical staining showed that @entity5 cells were positive for @entity2277 , but negative for @entity4483 protein; some @entity5 cells were positive for @entity2280 and @entity11280 . The follow-up was performed in 4 cases post-operation. One case experienced recurrence 1 month after surgical excision. CONCLUSIONS: Most of the @entity3169 and @entity3291 appear as a local yellow-pink, translucent, cystic and(or) with solid mass, and some of which had @entity5 . The preferred management route is complete surgical excision.

title: [Clinical and histopathological features of @entity3169 and XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'multiple tumors', 'tumors']

entities_list: @entity3291 :: ('MESH:D009232', 'Disease') :: ['myxomas', 'angiomyxoma']

entities_list: @entity3169 :: ('MESH:D003229', 'Disease') :: ['conjunctival angiomyxoma', 'conjunctival myxoma']

answer: @entity3291 :: (MESH:D009232,Disease) :: ['angiomyxoma']


abstract: BACKGROUND: Pneumonectomy is associated with a significant incidence of @entity260 . The purpose of this study is to identify the risk factors associated with adverse outcomes. METHODS: One hundred thirty-six @entity1 with @entity358 who underwent pneumonectomy were included in this retrospective analysis. @entity260 were observed during the 30-day follow-up. Univariate and multivariate analysis was performed to investigate the risk factors of pneumonectomy among the @entity1 . RESULTS: @entity260 were observed in 33 @entity1 (24.26%). The rate of @entity292 was 6.1% (9 of 136). Five perioperative @entity204 (3.68%) were noted. Univariate analysis and multivariate analysis indicated that @entity66 (hazard ratio [HR], 3.158; 95% confidence interval [CI], 1.248 to 7.992; p = 0.015) and operation duration (HR, 2.508; 95% CI, 1.035 to 6.080; p = 0.042) were independent risk factors of @entity260 , and that @entity66 (HR, 6.409; 95% CI, 1.669 to 6.021; p = 0.011) and pulmonary function (HR, 6.159; 95% CI, 0.018 to 0.625; p = 0.013) were independent risk factors of @entity292 for @entity1 with @entity358 after pneumonectomy. CONCLUSIONS: A high incidence of complications was reported among @entity1 with @entity358 after pneumonectomy. The @entity66 and operation duration were the best independent predictors of morbidity after this surgery. With careful @entity1 selection and operative technique, morbidity and mortality rates could be comparable to those for pneumonectomy in @entity5 @entity1 . Pneumonectomy is still a satisfactory treatment method for @entity358 .

title: Risk factors for early @entity260 after pneumonectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['type of disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Postoperative complications']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['benign lung disease']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['bronchopleural fistula']

answer: @entity358 :: (MESH:D008171,Disease) :: ['benign lung disease']


abstract: PURPOSE: This study aimed to examine whether (i) objective markers of sleep quantity and quality are altered in endurance athletes experiencing overreaching in response to an overload training program and (ii) potential reduced sleep quality would be accompanied with a higher prevalence of @entity1729 in this population. METHODS: Twenty-seven trained male triathletes were randomly assigned to either overload (n = 18) or normal (CTL, n = 9) training groups. Respective training programs included a 1-wk moderate training phase followed by a 3-wk period of overload or normal training, respectively, and then a subsequent 2-wk taper. Maximal aerobic power and @entity26 uptake (VO2max) from incremental cycle ergometry were measured after each phase, whereas mood states and incidences of illness were determined from questionnaires. Sleep was monitored every night of the 6 wk using wristwatch actigraphy. RESULTS: Of the 18 overload training group subjects, 9 were diagnosed as functionally overreached (F-OR) after the overload period, as based on declines in performance and VO2max with concomitant high perceived fatigue (P < 0.05), whereas the other 9 overload subjects showed no decline in performance (AF, P > 0.05). There was a significant time-group interaction for @entity25 ( @entity25 ), @entity25 ( @entity25 ), and immobile time (IT). Only the F-OR group demonstrated a decrease in these three parameters (-7.9%    6.7%, -1.6%    0.7%, and -7.6%    6.6% for @entity25 , @entity25 , and IT, respectively, P < 0.05), which was reversed during the subsequent taper phase. Higher prevalence of @entity1729 were also reported in F-OR (67%, 22%, and 11% incidence rate for F-OR, AF, and CTL, respectively). CONCLUSION: This study confirms @entity25 and @entity101 in endurance athletes who present with symptoms of F-OR during periods of high volume training.

title: Evidence of disturbed sleep and XXXX in overreached endurance athletes.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increased illness']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper respiratory tract infections']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep efficiency', 'SE', 'SD', 'sleep disturbances', 'sleep duration']

answer: @entity101 :: (MESH:D006973,Disease) :: ['increased illness']


abstract: The gracile axonal @entity3986 (gad) @entity19 is an autosomal recessive mutant that shows @entity2055 at an early stage, followed by @entity2055 at a later stage. Pathologically, the mutant is characterized by 'dying-back' type axonal degeneration and formation of spheroid bodies in nerve terminals. Recent pathological observations have associated brain ageing and @entity179 with progressive accumulation of ubiquitinated protein conjugates. In gad @entity19 , accumulation of amyloid beta-protein and ubiquitin-positive deposits occur retrogradely along the sensory and motor nervous systems. We previously reported that the gad mutation was transmitted by a gene on chromosome 5 (refs 10,11). Here we find that the gad mutation is caused by an in-frame deletion including exons 7 and 8 of @entity10500 , encoding the ubiquitin @entity1473 -terminal hydrolase (UCH) isozyme ( @entity10500 ) selectively expressed in the nervous system and testis. The gad allele encodes a truncated @entity10500 lacking a segment of 42 @entity1522 containing a catalytic residue. As @entity10500 is thought to stimulate protein degradation by generating free monomeric ubiquitin, the gad mutation appears to affect protein turnover. Our data suggest that altered function of the ubiquitin system directly causes @entity179 . The gad @entity19 provides a useful model for investigating @entity1 @entity179 .

title: Intragenic deletion in the gene encoding ubiquitin XXXX -terminal hydrolase in gad @entity19 .

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity1473 :: ('CHEBI:46883', 'Chemical') :: ['carboxy']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['dystrophy']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative diseases', 'neurodegenerative disorders']

entities_list: @entity2055 :: ('MESH:D001259', 'Disease') :: ['sensory ataxia', 'motor ataxia']

answer: @entity1473 :: (CHEBI:46883,Chemical) :: ['carboxy']


abstract: BACKGROUND AND OBJECTIVES: There has been great enthusiasm for the technique of transanal total mesorectal excision. Coupled with this procedure, we performed single-incision laparoscopic surgery for left colon mobilization. This is a description of our initial experience with the combined approach. METHODS: @entity1 with distal or mid @entity5 were included. The operation was performed by 2 teams: one team performed the single-incision mobilization of the left colon via the right lower quadrant ileostomy site, and the other team performed the total mesorectal excision with a transanal platform. RESULTS: During the study period, 10 @entity1 (5 @entity1 ) with @entity188 underwent the surgery. The mean age was 62.2    11.1 years, and the mean body mass index was 23.4    3.2 kg/m(2). The @entity5 's mean distance from the anal verge was 5.1    2.5 cm. The median operating time was 247.5 minutes (range, 188-462 minutes). The mean estimated @entity190 was 124    126 mL (range, 10-188 mL). Conversion to multiport laparoscopy was needed in one case (10%). @entity282 , as reflected by the @entity158 score, was minimal. The mean number of lymph nodes harvested was 15.6    3.8. All specimens had clear distal and circumferential radial margins. The overall complication rate was 10%. CONCLUSION: Our experience showed transanal total mesorectal excision with single-incision laparoscopy to be a feasible option for @entity5 . @entity1 reported minimal @entity282 . Further studies on the long-term outcome are warranted.

title: Transanal Total Mesorectal Excision With Single-Incision Laparoscopy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer']

entities_list: @entity188 :: ('MESH:D012004', 'Disease') :: ['cancer of the rectum']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain', 'Postoperative pain']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Rectal Cancer']


abstract: OBJECTIVES: Erysipelas is an @entity4409 caused by Gram-positive bacteria @entity13553 . Among the domestic animals, @entity12526 ( @entity1707 f. domestica) suffers most frequently from the disease in @entity1 environment. This is a typical @entity4409 observed mainly in occupational groups employed in agriculture, farming (of animals and birds), fishing and manufacturing industry. METHODS: We are presenting the clinical course of @entity281 ( @entity13553 ) and discuss clinical forms. @entity13553 in @entity1 may have the following clinical course: mild form of @entity272 diagnosed as local erythema (erysipeloid), disseminated form of @entity272 and the most serious form of @entity281 ( @entity884 and @entity295 ). Mild @entity272 and local erythema are the most common forms. Very rare case of @entity281 course has been presented in which after initial phase the disease was generalised to the abscesses formation in paravertebral space, @entity1511 and @entity3509 formation in spinal canal. In the presented clinical case, the @entity1 was suffering from @entity6 . It was probably an additional risk factor of the disease generalisation. @entity1 underwent @entity3509 in spinal canal, after which his neurological status gradually improved. Antibiotic therapy was implemented and continued for 8 weeks. Such course of erysipelas was not previously described in the literature. RESULTS: After therapy neurological status was improved. In follow MRI control exam @entity3509 and @entity1511 was successfully eliminated. CONCLUSIONS: Various complications of the disease, such as @entity884 and @entity340 , are well known and are the most severe complications of the generalised @entity281 . Proper targeted and long-term antibiotic therapy is crucial.

title: @entity3509 in spinal canal in thoracic region, abscesses in paravertebral space, XXXX : in clinical course of zoonosis @entity13553 .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patient', 'Patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4409 :: ('MESH:D000820', 'Disease') :: ['animal-borne disease', 'animal disease']

entities_list: @entity3509 :: ('MESH:D004653', 'Disease') :: ['empyema', 'drainage of empyema']

entities_list: @entity1511 :: ('MESH:D013166', 'Disease') :: ['spondylitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infection of systemic course', 'animal-borne infection']

entities_list: @entity13553 :: ('1648', 'Species') :: ['Erysipelothrix rhusiopathiae', 'E. rhusiopathiae']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infection']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['heart valves disturbances']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['endocarditis']

answer: @entity1511 :: (MESH:D013166,Disease) :: ['spondylitis']


abstract: BACKGROUND: There is no specific serum-based biomarker for the diagnosis or prognosis of relapsing-remitting @entity15 (RRMS). OBJECTIVE: We investigated whether levels of IgM antibodies to @entity28175 (GAGA4) or to a panel of four @entity413 -based glycans could differentiate @entity15 from @entity16 ( @entity16 ) or predict risk of early relapse following first presentation (FP) of RRMS. METHODS: Retrospective analysis of 440 sera samples of three cohorts: A) FP-RRMS (n = 44), @entity16 (n = 44); B) FP-RRMS (n = 167), @entity16 (n = 85); and C) FP (n = 100). Anti-GAGA4 IgM levels were measured by enzyme immunoassay in cohort-A and cohort-B. Cohort-C IgM antibodies to @entity413 -based glycan panel were measured by immunofluorescence. RESULTS: FP-RRMS had higher levels of anti-GAGA4 IgM than @entity16 @entity1 (cohort-A, P = 0.01; cohort-B, P = 0.0001). Sensitivity and specificity were 27% and 97% for cohort-A; and 26% and 90% for cohort-B, respectively. In cohort-C, 58 @entity1 experienced early relapse (<24 months), 31 had late relapse (> or =24 months), and 11 did not experience second attack during follow-up. Kaplan-Meier curves demonstrated decrease in time to next relapse for @entity1 positive for the antibody panel (P = 0.02, log rank). CONCLUSIONS: Serum anti-GAGA4 IgM discerns FP-RRMS @entity1 from @entity16 @entity1 . Higher levels of serum anti-alpha- @entity413 IgM in FP @entity1 predict imminent early relapse.

title: Anti-alpha- @entity413 -based glycan IgM antibodies predict relapse activity in XXXX after the first neurological event.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['other neurological diseases', 'OND']

entities_list: @entity28175 :: ('CHEBI:18167', 'Chemical') :: ['Glc(alpha1,4)Glc(alpha)']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']


abstract: Immunoglobulin G4 (IgG4)-related disorders can occur in the respiratory system. However, the clinicopathologic characteristics have not been well clarified. In this study, we examined clinical and pathologic features of, and follow-up data on, IgG4-related lung and @entity456 . The @entity1 group consisted of 17 males and 4 females with an average age of 69 years (range: 42 to 76). @entity358 in 16 @entity1 and @entity456 in 5 @entity1 were examined. Histologically, all lesions showed diffuse lymphoplasmacytic infiltration. Irregular @entity82 and obliterative vascular changes were more common in solid areas. Nine cases (43%) had @entity1712 with more than 5 cells per high-power field. Immunostaining revealed numerous IgG4-positive plasma cells in inflamed areas. @entity32 was distributed with intrapulmonary connective tissue. @entity358 showed a variety of morphologic changes according to the predominant area of @entity32 . Serum IgG4 concentrations were elevated in 9 of 11 @entity1 tested (average 6.9 g/L; range 0.3 to 18.0 g/L; normal range <1.35 g/L). Extra-pulmonary and extra-pleural IgG4-related lesions were identified in 9 @entity1 (43%), and developed simultaneously or asynchronously during follow up. All @entity1 treated with @entity230 responded, but some @entity854 remained in 3 @entity1 . Interestingly, 1 @entity1 was found to have a primary @entity420 against a background of IgG4-related @entity358 during follow up. In conclusion, IgG4-related diseases show a greater variety of @entity358 than previously thought. It is important, therefore, to know the morphologic variety and clinicopathologic characteristics of this disorder.

title: IgG4-related lung and XXXX : a clinicopathologic study of 21 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilic infiltration']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'Sclerosing inflammation']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['radiologic abnormalities']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease', 'pulmonary and pleural lesions', 'Pulmonary lesions']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural lesions']

answer: @entity456 :: (MESH:D010995,Disease) :: ['pleural disease']


abstract: Differential inhibition of @entity2404 ( @entity3447 ) and prostacyclin (PGI2) biosynthesis has an antithrombotic potential, since it may change the @entity3447 /PGI2 formation ratio in a favourable direction. Very low doses of @entity117 ( @entity1281 ) have been demonstrated to elicit differential inhibition of @entity3447 and PGI2 formation in healthy subjects; whether a similar effect can be obtained in @entity1 with @entity731 is still an open question. We addressed this by analyzing the urinary excretion of the 2,3-dinor-metabolites of @entity3447 (Tx-M) and PGI2 ( @entity14243 -M) in 10 @entity1 with severe @entity731 during 10 consecutive days. The first three days were a basal period, under which no treatment was given. During the subsequent seven days a daily 50 mg oral dose of @entity1281 was administered. In the basal state urinary Tx-M did not differ from that of @entity14243 -M, the median excretion rates of the two eicosanoid metabolites being 526 (range 68-1490) and 562 (range 93-1970) pg/mg @entity1011 , respectively. During @entity1281 treatment urinary Tx-M fell to a lower (p less than 0.001) level than @entity14243 -M. Thus, during the last 5 days of @entity1281 treatment the median excretion of Tx-M was depressed (p less than 0.001) to 148 (range 48-428) pg/mg @entity1011 , while that of @entity14243 -M was decreased (p less than 0.01) to 313 (range 42-2658) pg/mg @entity1011 . These data indicate that a daily 50 mg dose of @entity1281 inhibits cardiovascular formation of @entity1813 in @entity1 with severe @entity731 and increased platelet @entity3447 formation. Furthermore, this dose of @entity1281 inhibits the formation of @entity3447 more than that of PGI2.

title: Differential inhibition of @entity2404 and prostacyclin synthesis by low dose @entity117 in @entity731 XXXX .

entities_list: @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity1813 :: ('MESH:D015777', 'Chemical') :: ['eicosanoids']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: RATIONALE: @entity1770 ( @entity10916 ) is an atypical antipsychotic approved by the Food and Drug Administration for use in major @entity308 as an adjunct to antidepressants. However, the precise mechanisms responsible for the effectiveness of @entity10916 augmentation are not fully understood. OBJECTIVES: The current study was aimed at examining the effects of @entity10916 administration alone and in combination with the selective @entity750 reuptake inhibitors (SSRI) @entity837 (ESC) on the firing of @entity750 ( @entity750 ), @entity1063 (NE), and @entity935 (DA) neurons. METHODS: Electrophysiological experiments were carried out in anesthetized @entity35 . ESC was delivered via subcutaneously implanted osmotic minipumps at a dose of 10 mg/kg/day. @entity10916 was subcutaneously injected daily at a dose of 2 mg/kg/day. Both drugs were administered for 2 and 14 days alone and in combination. Control @entity35 received physiological saline in analogous regimens. RESULTS: Two-day ESC administration resulted in a significant decrease in the firing rate of @entity750 , NE, and DA neurons. Following 14 days of ESC administration, @entity750 firing returned to the baseline. The firing rate of NE and DA neurons remained significantly decreased. @entity10916 administered for 2 or 14 days significantly increased the firing rate of @entity750 neurons by 36% and 48%, respectively, but not those of DA and NE neurons. Desensitization of somatodendritic @entity750 autoreceptors was observed after 2 days of @entity10916 administration. The combination of the two drugs reversed the inhibitory action of ESC on the firing rate of @entity750 , NE, and DA neurons. CONCLUSION: The present study showed that addition of @entity10916 to an SSRI regimen reverses the inhibitory action of the SSRI on monoaminergic neuronal firing.

title: Electrophysiological studies in the @entity35 brain on the basis for XXXX augmentation of antidepressants in major @entity308 .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity837 :: ('MESH:D015283', 'Chemical') :: ['escitalopram']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

entities_list: @entity1770 :: ('MESH:C094645', 'Chemical') :: ['Aripiprazole']

answer: @entity1770 :: (MESH:C094645,Chemical) :: ['aripiprazole']


abstract: The histone demethylase @entity27564 has been implicated in cell cycle regulation and tumorigenesis. In addition, it has been reported that @entity27564 is highly expressed in various @entity1 @entity5 , including @entity1778 . However, it is not clearly understood how @entity27564 contributes to @entity3052 ( @entity3052 ) cell proliferation. In this study, we investigated the cellular and molecular function of @entity27564 in @entity3052 cells. In @entity3052 cell lines and @entity3052 -derived ALDH(hi) (high @entity264 dehydrogenase activity)/ @entity2280 (+) cells, the levels of @entity27564 mRNA were significantly higher than in normal ALDH(hi) / @entity2280 (+) cells. Reduction of @entity27564 expression in @entity3052 cells inhibited cell proliferation compared to control cells, through induction of G1 cell cycle arrest, an increase in the @entity9288 ( @entity9288 ) mRNA and protein expression. @entity27564 mRNA was overexpressed in all 133 @entity3052 clinical specimens tested (n   =   22, 57, 34, and 20 for M1, 2, 4, and 5 subtypes respectively). Compared to normal ALDH(hi) / @entity2280 (+) cells, @entity27564 gene expression was 1.57- to 1.87-fold higher in @entity3052 -derived ALDH(hi) / @entity2280 (+) cells. Moreover, the @entity27564 protein was more strongly expressed in @entity3052 -derived ALDH(hi) / @entity2280 (+) cells from compared to normal ALDH(hi) / @entity2280 (+) cells. In addition, depletion of @entity27564 reduced colony formation of @entity3052 -derived ALDH(hi) / @entity2280 (+) cells due to induction of @entity9288 ( @entity9288 ) expression through direct binding to @entity9288 ( @entity9288 ) promoter and loss of demethylation of H3K36me2. In summary, we found that @entity27564 mRNA is predominantly expressed in @entity3052 -derived ALDH(hi) / @entity2280 (+) cells, and that aberrant expression of @entity27564 induces @entity3052 cell proliferation through modulation of cell cycle progression. Thus, inhibition of @entity27564 expression represents an attractive target for @entity3052 therapy.

title: JmjC-domain containing histone demethylase 1B-mediated @entity9288 ( XXXX ) suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in @entity3052 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemias']

entities_list: @entity264 :: ('CHEBI:17478', 'Chemical') :: ['aldehyde']

answer: @entity9288 :: (1030,Gene) :: ['Ink4b']


abstract: BACKGROUND AND AIMS: @entity1561 is now the leading @entity409 in North America. The progression of @entity1561 to the inflammatory condition, @entity7936 is complex and currently not well understood. Intestinal microbial @entity6636 has been implicated in the development of @entity1561 and progression of @entity7936 . Volatile organic compounds are byproducts of microbial metabolism in the gut that may enter portal circulation and have hepatotoxic effects contributing to the pathogenesis of @entity7936 . To test this hypothesis, we measured volatile organic compounds in cecal luminal contents and portal venous blood in a @entity19 model of @entity7936 . METHODS: Gas chromatography-mass spectrometry analysis was conducted on cecal content and portal vein blood for volatile organic compound detection from @entity19 fed a @entity1853 and @entity1877 deficient diet, which induces @entity7936 . The colonic microbiome was studied by 16S rRNA gene amplification using the Illumina MiSeq platform. RESULTS: Sixty-eight volatile organic compounds were detected in cecal luminal content, a subset of which was also present in portal venous blood. Importantly, differences in portal venous volatile organic compounds were associated with diet-induced @entity1560 establishing a biochemical link between gut microbiota-derived volatile organic compounds and increased susceptibility to @entity7936 . CONCLUSION: Our model creates a novel tool to further study the role of gut-derived volatile organic compounds in the pathogenesis of @entity7936 .

title: Unique microbial-derived volatile organic compounds in portal venous circulation in @entity19 XXXX .

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatohepatitis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity7936 :: ('MESH:D005235', 'Disease') :: ['non-alcoholic steatohepatitis']

entities_list: @entity6636 :: ('MESH:D064806', 'Disease') :: ['dysbiosis']

entities_list: @entity1853 :: ('MESH:D008715', 'Chemical') :: ['methionine']

entities_list: @entity1561 :: ('MESH:D065626', 'Disease') :: ['non-alcoholic fatty liver disease', 'Non-alcoholic fatty liver disease']

answer: @entity1561 :: (MESH:D065626,Disease) :: ['non-alcoholic fatty liver disease']


abstract: BACKGROUND: @entity1369 antagonists have proven efficacy for management of resistant @entity101 and @entity644 reduction; however, they are not widely used due to risk of @entity4144 . This study assesses the risk factors for @entity4144 in @entity1 with @entity740 ( @entity740 ) and resistant @entity101 whose blood pressure (BP) is reduced to a guideline goal. METHODS: This is a two-center study conducted in university-based @entity101 clinics directed by clinical @entity101 specialists. Forty-six @entity1 with resistant @entity101 and stages 2 or 3 @entity740 (mean estimated glomerular filtration rate (eGFR) 56.5 + or - 16.2 ml/min/1.73 m(2)) were evaluated for safety and efficacy of @entity1369 blockade added to preexisting BP-lowering regimens. All @entity1 were on three mechanistically complementary antihypertensive agents including a diuretic and a @entity916 -angiotensin system blocker. @entity1 were evaluated after a median of 45 treatment days. The primary endpoint was change in systolic BP. Secondary endpoints included change in serum @entity972 , @entity1011 , eGFR, diastolic BP and tolerability. RESULTS: The mean age of the @entity1 studied was 64.9 + or - 10.7 years, all were @entity28 and 86% had @entity164 2 @entity6 , with 82% being African-American. Addition of @entity1369 antagonism yielded a further mean reduction in systolic BP of 14.7 + or - 5.1 mm Hg (p = 0.001). Females with BMI >30 and those with a baseline systolic BP >160 mm Hg were more likely to have a greater BP reduction to @entity1369 antagonism. In total, 39% of the @entity1 had a >30% decrease in eGFR when the BP goal was achieved. The mean increase in serum @entity972 was 0.4 mEq/l above baseline (p = 0.001), with 17.3% manifesting @entity4144 , i.e. serum @entity972 >5.5 mEq/l. Predictors of @entity4144 included a baseline eGFR of < or = 45 ml/min/1.73 m(2) in whom serum @entity972 was >4.5 mEq/l on appropriately dosed diuretics. Contributing risks in this subgroup included a systolic BP reduction of >15 mm Hg associated with an eGFR fall of >30%. CONCLUSION: @entity1369 antagonism is effective and safe for achieving a BP goal among @entity1 with @entity2316 when added to a triple antihypertensive regimen that includes a blocker of the @entity916 -angiotensin system and an appropriately selected and dosed diuretic. Caution is advised when using @entity1369 blockade for BP control in @entity1 with advanced stage 3 @entity8 with a serum @entity972 of >4.5 mEq/l for safety reasons.

title: Predictors of @entity4144 risk following XXXX control with @entity1369 blockade.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'people']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity1369 :: ('MESH:D000450', 'Chemical') :: ['Aldosterone', 'aldosterone']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity4144 :: ('MESH:D006947', 'Disease') :: ['hyperkalemia']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: BACKGROUND: Identifying @entity1 with chronic @entity4512 using database searches is difficult, as @entity1118 is not represented with a unique diagnostic code in electronic primary care records. Aim This paper describes the development and implementation of a search strategy to identify @entity1 with chronic @entity4512 in primary care databases to invite them to participate in a randomised controlled trial. METHODS: We used an exploratory, iterative approach. The first phase involved consultations with IT specialists, practice managers and doctors to gain an understanding about the processes and issues of electronic coding. In the second and third phases, we determined the most appropriate search terms and strategies. In the final phase, we tested, modified and re-tested the search strategy until the quantity and quality of the output appeared good enough to be used in general practices with different IT systems. This strategy was then implemented to recruit @entity1 for a trial. Findings We identified three main search 'domains': prescribing, coding and attendance. We found the most useful identifier for @entity1118 was the use of repeat medication. Wide variations in coding terms for @entity1118 were seen between practices and individuals. Understanding 'coding cultures' were necessary to inform the electronic searches. In the case of @entity1118 , searching on repeat medication for analgesia, low dose antidepressants and carefully selected coding terms captured most relevant @entity1 .

title: Developing and implementing electronic search strategies to recruit XXXX with chronic @entity4512 in primary care databases.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity4512 :: ('MESH:D059352', 'Disease') :: ['musculoskeletal pain']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A large outbreak of haemorrhagic @entity221 (subsequently named @entity2598 ) occurred in southern Sudan between June and November 1976. There was a total of 284 cases; 67 in the source town of Nzara, 213 in Maridi, 3 in Tembura, and 1 in Juba. The outbreak in Nzara appears to have originated in the workers of a @entity2708 factory. The disease in Maridi was amplified by transmission in a large, active hospital. Transmission of the disease required close contact with an acute case and was usually associated with the act of nursing a @entity1 . The incubation period was between 7 and 14 days. Although the link was not well established, it appears that Nzara could have been the source of @entity281 for a similar outbreak in the Bumba Zone of Zaire.In this outbreak @entity2598 was a unique clinical disease with a high mortality rate (53% overall) and a prolonged recovery period in those who survived. Beginning with an @entity683 -like syndrome, including @entity221 , @entity10 , and joint and @entity925 , the disease soon caused @entity294 (81%), @entity391 (59%), @entity662 (83%), @entity158 and dryness of the throat (63%), and @entity1910 (52%). @entity548 manifestations were common (71%), being present in half of the recovered cases and in almost all the fatal cases.Two post mortems were carried out on @entity1 in November 1976. The histopathological findings resembled those of an acute @entity1800 and although the features were characteristic they were not exclusively diagnostic. They closely resembled the features described in Marburg @entity778 , with focal eosinophilic @entity39 in the liver and destruction of lymphocytes and their replacement by plasma cells. One case had evidence of @entity4295 .Two strains of Ebola virus were isolated from acute phase sera collected from acutely ill @entity1 in Maridi hospital during the investigation in November 1976. Antibodies to Ebola virus were detected by immunofluorescence in 42 of 48 @entity1 in Maridi who had been diagnosed clinically, but in only 6 of 31 @entity1 in Nzara. The possibility of the indirect immunofluorescent test not being sufficiently sensitive is discussed.Of Maridi case contacts, in hospital and in the local community, 19% had antibodies. Very few of them gave any history of illness, indicating that Ebola virus can cause mild or even @entity4092 . Of the cloth room workers in the Nzara @entity2708 factory, 37% appeared to have been infected, suggesting that the factory may have been the prime source of @entity281 .

title: XXXX in Sudan, 1976. Report of a WHO/International Study Team.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['virus infection']

entities_list: @entity2598 :: ('MESH:D019142', 'Disease') :: ['Ebola haemorrhagic fever']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Haemorrhagic']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity4295 :: ('MESH:D007683', 'Disease') :: ['renal tubular necrosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pains']

entities_list: @entity4092 :: ('MESH:D058345', 'Disease') :: ['subclinical infections']

answer: @entity2598 :: (MESH:D019142,Disease) :: ['Ebola haemorrhagic fever']


abstract: Handheld mobile phones were introduced in Sweden during the late 1980s. The purpose of this population-based, case-control study was to test the hypothesis that long-term mobile phone use increases the risk of @entity1313 . The authors identified all cases aged 20-69 years who were diagnosed with @entity11 or @entity1653 during 2000-2002 in certain parts of Sweden. Randomly selected controls were stratified on age, gender, and residential area. Detailed information about mobile phone use was collected from 371 (74%) @entity11 and 273 (85%) @entity1653 cases and 674 (71%) controls. For regular mobile phone use, the odds ratio was 0.8 (95% confidence interval: 0.6, 1.0) for @entity11 and 0.7 (95% confidence interval: 0.5, 0.9) for @entity1653 . Similar results were found for more than 10 years' duration of mobile phone use. No risk increase was found for ipsilateral phone use for @entity5 located in the temporal and parietal lobes. Furthermore, the odds ratio did not increase, regardless of @entity5 histology, type of phone, and amount of use. This study includes a large number of long-term mobile phone users, and the authors conclude that the data do not support the hypothesis that mobile phone use is related to an increased risk of @entity11 or @entity1653 .

title: Long-term mobile phone use and XXXX risk.

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['brain tumor']


abstract: BACKGROUND: Large artery stiffness is a major risk factor for the development of @entity101 and @entity65 . Persistent @entity1556 accelerates the progression of arterial stiffness. METHODS: Forty-three unmedicated prehypertensive (systolic blood pressure (SBP) = 120-139 mm Hg or diastolic blood pressure (DBP) = 80-89 mm Hg) @entity1 and @entity1 and 15 normotensive time-matched control subjects (NMTCs; n = 15) aged 18-35 years of age met screening requirements and participated in the study. @entity1556 subjects were randomly assigned to a resistance exercise training (PHRT; n = 15), endurance exercise training ( @entity30637 ; n = 13) or time-control group (PHTC; n = 15). Treatment groups performed exercise training 3 days per week for 8 weeks. Pulse wave analysis, pulse wave velocity ( @entity122 ), and central and peripheral blood pressures were evaluated before and after exercise intervention or time-matched control. RESULTS: PHRT and @entity30637 reduced resting SBP by 9.6  3.6mm Hg and 11.9  3.4mm Hg, respectively, and DBP by 8.0  5.1mm Hg and 7.2  3.4mm Hg, respectively (P < 0.05). PHRT and @entity30637 decreased augmentation index (AIx) by 7.5%    2.8% and 8.1%    3.2% (P < 0.05), AIx@75 by 8.0%    3.2% and 9.2%    3.8% (P < 0.05), and left ventricular wasted pressure energy, an index of extra left ventricular myocardial @entity26 requirement due to early systolic wave reflection, by 573  161 dynes s/cm(2) and 612  167 dynes s/cm(2) (P < 0.05), respectively. PHRT and @entity30637 reduced carotid-radial @entity122 by 1.02  0.32 m/sec and 0.92  0.36 m/sec (P < 0.05) and femoral-distal @entity122 by 1.04  0.31 m/sec and 1.34  0.33 m/sec (P < 0.05), respectively. No significant changes were observed in the time-control groups. CONCLUSIONS: This study suggests that both resistance and endurance exercise alone effectively reduce peripheral arterial stiffness, central blood pressures, augmentation index, and myocardial @entity26 demand in young prehypertensive subjects.

title: Exercise training reduces peripheral arterial stiffness and myocardial XXXX demand in young prehypertensive subjects.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1556 :: ('MESH:D058246', 'Disease') :: ['prehypertension', 'Prehypertensive']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: PURPOSE: @entity198 is a chronic immune-mediated disease leading to unilateral @entity194 on magnetic resonance imaging (MRI) and progressive @entity51 . Until now, quantitative parameters describing the course of the disease on MRI require manual intervention and are, therefore, time-consuming and observer-dependent. Furthermore, regional @entity194 differences cannot be evaluated with the previously published methods. In this study we present a fully automated volumetric approach applied to serial MRI scans of 12 @entity1 with @entity198 . METHODS: We retrospectively analyzed 12 @entity1 with @entity198 with a disease onset between 2001 and 2008. All @entity1 underwent a total of 66 serial MRI scans including a three-dimensional T(1) data set. The volumetric analysis was based on standard procedures of the freely available software FMRIB Software Library (FSL) and required about 45 min per scan. Furthermore, planimetric analyses were performed on 51 scans as described previously. KEY FINDINGS: The relative and absolute volume loss of the affected hemisphere was significantly higher compared to the unaffected hemisphere. Referring to regional @entity194 differences our results show that the frontal lobe and the insula were preferentially involved in the @entity2537 . The degree of hemispheric, parietal, and occipital @entity194 was negatively correlated with the age at disease onset, indicating a more aggressive and outspread disease in young @entity1 compared to adolescents. Volumetric hemispheric ratio and planimetric hemispheric ratio correlated significantly, but planimetric hemispheric ratio underestimated the real degree of @entity5043 , especially in @entity1 with predominant affections outside the frontoinsular region. SIGNIFICANCE: The volumetric analysis presented here offers a precise assessment of the disease progression in @entity198 in an observer-independent and time-efficient manner and gives an interesting insight into the course of the disease on MRI. The degree of @entity194 evaluated with this method correlates with clinical parameters and is comparable to @entity194 rates in @entity1 receiving immunotherapy in preceding planimetric MRI studies.

title: Automated 3D MRI volumetry reveals regional @entity194 differences in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity198 :: ('MESH:D004660', 'Disease') :: ['Rasmussen encephalitis']

entities_list: @entity2537 :: ('MESH:D020966', 'Disease') :: ['atrophic process']

entities_list: @entity5043 :: ('MESH:D005150', 'Disease') :: ['hemiatrophy']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficits']

answer: @entity198 :: (MESH:D004660,Disease) :: ['Rasmussen encephalitis']


abstract: BACKGROUND: Carotid endarterectomy yields greater risk reduction for ipsilateral @entity385 when performed within two-weeks of the last cerebrovascular symptom than when performed two-weeks or more after the last symptom. However, additional benefit might be gained if carotid endarterectomy is performed earlier than within two-weeks. AIMS: To investigate the 90-day risk of ipsilateral @entity385 recurrence after @entity1939 fugax, @entity732 , @entity63 , or minor @entity385 in @entity1 with 50-99% @entity543 before carotid endarterectomy, with emphasis on the first 14 days. METHODS: Prospective cohort study. 230 consecutive @entity1 with symptomatic 50-99% @entity543 (North American Symptomatic Carotid Endarterectomy Trial grading method) who underwent evaluation before carotid endarterectomy. Of these, 183 underwent carotid endarterectomy; the median delay to carotid endarterectomy was 29 days. Blood pressure lowering medication was used by 93% and lipid-lowering medication by 90%. RESULTS: The risk of ipsilateral @entity385 recurrence before carotid endarterectomy was 5  2% (n = 12) within two-days, 7  9% (n = 18) within seven-days, 11  2% (n = 25) within 14 days, and 18  6% (n = 33) within 90 days of the presenting event. The risk of ipsilateral @entity385 recurrence was higher if the presenting event was a @entity64 (adjusted hazard ratio 12  4, P = 0  015) or @entity63 (adjusted hazard ratio 10  2, P = 0  026) compared with an @entity1939 fugax. DISCUSSION: The risk of recurrent ipsilateral @entity385 was high within the first days of the presenting event. Many recurrences would likely have been avoided if carotid endarterectomy had been performed within the first days of the presenting event.

title: Risk of recurrent XXXX before carotid endarterectomy: the ANSYSCAP study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['transient ischemic attack']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['amaurosis']

entities_list: @entity732 :: ('MESH:D015356', 'Disease') :: ['retinal artery occlusion']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVES: The Pipeline embolization device (PED) (Chestnut Medical Technologies, Inc., Menlo Park, CA) is a new microcatheter-delivered endovascular construct designed to achieve the curative reconstruction of the parent arteries giving rise to wide-necked and fusiform @entity438 . We present our initial periprocedural experience with the PED and midterm follow-up results for a series of 53 @entity1 . METHODS: @entity1 harboring large and giant wide-necked, nonsaccular, and recurrent @entity438 were selected for treatment. All @entity1 were pretreated with dual antiplatelet medications for at least 72 hours before surgery and continued taking both agents for at least 6 months after treatment. A control digital subtraction angiogram was typically performed at 3, 6, and 12 months. RESULTS: Fifty-three @entity1 (age range, 11-77 years; average age, 55.2 years; 48 female) with 63 @entity438 were treated with the PED. Small (n = 33), large (n = 22), and giant (n = 8) wide-necked @entity439 were included. A total of 72 PEDs were used. Treatment was achieved with a single PED in 44 @entity439 , with 2 overlapping PEDs in 17 @entity439 , and with 3 overlapping PEDs in 2 @entity439 . The mean time between the treatment and last follow-up digital subtraction angiogram was 5.9 months (range, 1-22 months). Complete angiographic occlusion was achieved in 56%, 93%, and 95% of @entity439 at 3 (n = 42), 6 (n = 28), and 12 (n = 18) months, respectively. The only @entity439 that remained patent at the time of the 12-month follow-up examination had been treated previously with stent-supported coiling. The presence of a preexisting endoluminal stent may have limited the efficacy of the PED reconstruction in this @entity439 . No @entity439 demonstrated a deterioration of angiographic occlusion during the follow-up period (i.e., no recanalizations). No major complications ( @entity64 or @entity204 ) were encountered during the study period. Three @entity1 (5%), all with @entity439 , experienced transient exacerbations of preexisting @entity129 and @entity10 after the PED treatment. All 3 were treated with @entity288 , and these symptoms resolved within 1 month. CONCLUSION: Endovascular reconstruction with the PED represents a safe, durable, and curative treatment of selected wide-necked, large and @entity438 . The rate of complete occlusion at the time of the 12-month follow-up examination approached 100% in the present study. To date, no angiographic recurrences have been observed during serial angiographic follow-up.

title: Curative endovascular reconstruction of XXXX with the pipeline embolization device: the Buenos Aires experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial neuropathies']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'giant aneurysms', 'aneurysm']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['giant cerebral aneurysms', 'intracranial aneurysms']

answer: @entity438 :: (MESH:D002532,Disease) :: ['cerebral aneurysms']


abstract: PURPOSE: To evaluate the efficacy and safety of ablative dose hypofractionated @entity34 ( @entity34 ) for @entity1 with stage  I and recurrent @entity1149 ( @entity1149 ). @entity1 AND METHODS: A total of 55  @entity1 with stage  I (n  = 42) and recurrent (n  = 13) @entity1149 underwent hypofractionated @entity34 and were retrospectively reviewed. A  total dose of 50-72  CGE ( @entity1953 gray equivalent) in 5-12  fractions was delivered. RESULTS: The median follow-up duration was 29  months (range 4-95  months). There were 24  deaths (43.6%) during the follow-up period: 11  died of disease progression and 13  from other causes. Kaplan-Meier overall survival rate (OS) at 3  years was 54.9% and the median OS was 48.6  months (range 4-95  months). Local progression was observed in 7  @entity1 and the median time to local progression was 9.3  months (range 5-14  months). Cumulative actuarial local control rate (LCR), lymph node @entity3 -free survival, and distant @entity3 -free survival rates at 3  years were 85.4, 78.4, and 76.5%, respectively. Larger @entity5 diameter was significantly associated with poorer LCR (3-year: 94% for  <=3  cm vs. 65% for >3  cm, p  = 0.006) on univariate analysis and also an independent prognostic factor for LCR (HR 6.9, 95% CI  = 1.3-37.8, p  = 0.026) on multivariate analysis. No grade 3 or 4  treatment-related @entity137 developed. One grade 5  treatment-related adverse event occurred in a  @entity1 with symptomatic @entity2416 . CONCLUSIONS: Ablative dose hypofractionated @entity34 was safe and promising for stage  I and recurrent @entity1149 .

title: Ablative dose @entity34 for stage  I and recurrent @entity1149 : Ablative dose @entity34 for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung carcinoma']

entities_list: @entity2416 :: ('MESH:D054990', 'Disease') :: ['idiopathic pulmonary fibrosis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['proton beam therapy', 'PBT']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['NSCLC']


abstract: Activity-dependent synaptic plasticity has been implicated in the refinement and modification of neural circuits during development and learning. Previous studies show that activity-induced facilitation and potentiation are disrupted at larval neuromuscular junctions in the memory mutants dunce ( @entity36379 ) and rutabaga (rut) of @entity238 . The diminished learning-memory capacity and synaptic transmission plasticity have been associated with altered @entity268 levels since @entity36379 affects the @entity268 -specific phosphodiesterase and rut affects adenylate cyclase. In this study, the morphology of larval motor axon terminals was examined by anti-HRP immunohistochemistry. It was found that the numbers of terminal varicosities and branches were increased in @entity36379 mutants, which have elevated @entity268 concentrations. Such increase was suppressed in @entity36379 rut double mutants by rut mutations, which reduce @entity268 synthesis. More profuse projections of larval motor axons have also been reported in double-mutant combinations of ether    go-go (eag) and Shaker (Sh) alleles, which display greatly enhanced nerve activity as a result of reduction in different K+ currents. Therefore, we examined combinations of @entity36379 and rut with eag and Sh mutations to explore the possible relation between activity- and @entity268 -induced morphological changes. We found that the expanded projections in @entity36379 were further enhanced in double mutants of @entity36379 with either eag or Sh, an effect that could again be suppressed by rut. The results provide evidence for altered plasticity of synaptic morphology in memory mutants @entity36379 and rut and suggest a role of @entity268 cascade in mediating activity-dependent synaptic plasticity.

title: Synaptic plasticity in @entity238 memory and hyperexcitable mutants: role of XXXX cascade.

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity268 :: (CHEBI:17489,Chemical) :: ['cAMP']


abstract: CONTEXT: As a serious chronic condition from @entity0 treatment, @entity4269 or a syndrome of persistent @entity4 and symptoms is caused by chronic accumulation of lymph fluid in the interstitial spaces of the affected limb or surrounding areas. Although significant prevalence of ongoing multiple symptoms has been reported, little is known about how survivors with @entity4269 perceive and respond to @entity1109 in their daily lives. OBJECTIVES: The purpose of this study was to explore and describe @entity0 survivors' @entity4269 -related symptom experiences. METHODS: This study used a descriptive phenomenological method. Thirty-four @entity1 were recruited in the United States. Three in-depth interviews were conducted with each @entity1 ; a total of 102 interviews were completed, audio taped, and transcribed. Interview transcripts and field notes were the data sources for this analysis, which was part of three larger studies. Data were analyzed to identify the essential themes within and across cases. RESULTS: Four essential themes were revealed: living with perpetual discomfort, confronting the unexpected, losing pre- @entity4269 being, and feeling handicapped. @entity1 experienced multiple symptoms on a daily basis. @entity147 was heightened when @entity1 expected symptoms to disappear, but instead, they remained as a "perpetual discomfort." Moreover, distress was intensified when symptoms evoked unexpected situations or when symptoms elicited emotional responses powerful enough to change perceived personal identity. CONCLUSIONS: Findings suggest that symptom distress may encompass temporal, situational, and attributive dimensions. Prospective studies are needed to examine @entity4269 -related symptom distress in terms of these dimensions so that more specific interventions can be developed to target distress occurring in each dimension.

title: @entity0 survivors' experiences of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'participant', 'Participants']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['lymphedema-related symptoms']

entities_list: @entity147 :: ('MESH:D005316', 'Disease') :: ['Distress']

answer: @entity1109 :: (MESH:D012678,Disease) :: ['lymphedema-related symptoms']


abstract: OBJECTIVE: To find the prevalence of @entity2531 ( @entity2531 ) among internal medical inpatients and to study the comorbidity with other @entity146 . METHODS: Of 392 eligible consecutive medical inpatients, 294 (75%) accepted to participate and, using a two-phase design, were assessed for @entity1479 and DSM-IV somatoform diagnoses and for @entity1479 -10 psychiatric diagnoses. RESULTS: A total of 18.1% (95% CI: 12.8-24.9%) of the @entity1 fulfilled the diagnostic criteria for an @entity1479 , and 20.2% (95% CI:14.7-27.2% ) for a DSM-IV @entity74 . The prevalence of specified disorders revealed marked differences between the two diagnostic systems, e.g., concerning @entity74 ( @entity74 ), which was more prevalent in the @entity1479 -10 (5%) than in the DSM-IV (1.5%) equivalent. Quite the contrary was found in undifferentiated @entity74 (0.7% in @entity1479 -10 and 10% in DSM-IV). According to @entity1479 -10 criteria, 3.5% had @entity16251 , 2.6% a @entity4785 , 3.2% a somatoform @entity5433 , 1.5% had @entity24497 or persistent somatoform @entity2531 , and 5% had an @entity74 , unspecified. @entity2531 were more prevalent among younger females. Thirty-six percent of the @entity1 with @entity2531 also had another @entity146 , 11% a @entity308 , and 25% an @entity148 . The physicians detected about 1/3 of the cases. CONCLUSION: @entity2531 were prevalent among internal medical inpatients especially among younger @entity1 .

title: The prevalence of XXXX among internal medical inpatients.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders', 'psychiatric disorder']

entities_list: @entity4785 :: ('MESH:D004213', 'Disease') :: ['dissociative disorder']

entities_list: @entity24497 :: ('MESH:D009440', 'Disease') :: ['neurasthenia']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorder']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['SD', 'somatisation disorder']

entities_list: @entity2531 :: ('MESH:D013001', 'Disease') :: ['somatoform disorders', 'Somatoform disorders', 'SDs', 'pain disorder']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity16251 :: ('MESH:D006998', 'Disease') :: ['hypochondriasis']

answer: @entity2531 :: (MESH:D013001,Disease) :: ['somatoform disorders']


abstract: BACKGROUND: @entity2489 ( @entity2489 ) caused by drug-resistant @entity3064 is associated with high mortality in critically ill @entity1 . We identified the prognostic factors of 30-day mortality in @entity1 with @entity2489 caused by drug-resistant A. baumannii and compared survival outcomes among multidrug-resistant (MDR), extensively drug-resistant (XDR) and @entity3013 ( @entity3013 ) @entity2489 . METHODS: A retrospective cohort study was conducted in the Medical Intensive Care Unit at Chiang Mai University Hospital, Thailand. All adult @entity1 diagnosed with @entity2489 between 2005 and 2011 were eligible. Univariable and multivariable Cox's proportional hazards regression were performed to identify the prognostic factors of 30-day mortality. RESULTS: A total of 337 @entity1 with microbiologically confirmed @entity2489 were included. The proportion of drug-sensitive (DS), MDR, XDR, and @entity3013 A. baumannii were 9.8%, 21.4%, 65.3%, and 3.6%, respectively. The 30-day mortality rates were 21.2%, 31.9%, 56.8%, and 66.7%, respectively. The independent prognostic factors were SOFA score >5 (hazard ratio (HR)   =   3.33, 95% confidence interval (CI) 1.94-5.72, P   <   0.001), presence of @entity326 (HR   =   2.66, 95% CI 1.71-4.12, P   <   0.001), Simplified Acute Physiology Score (SAPS) II >45 (HR   =   1.58, 95% CI 1.01-2.46, P   =   0.045), and inappropriate initial antibiotic treatment (HR   =   1.53, 95% CI 1.08-2.20, P   =   0.016). CONCLUSIONS: Drug-resistant A. baumannii, particularly XDR and @entity3013 , was associated with a high mortality rate. @entity326 , high SAPS II, high SOFA score, and inappropriate initial antibiotic treatment were independent prognostic factors for 30-day mortality.

title: Prognostic factors associated with mortality of drug-resistant XXXX ventilator-associated pneumonia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock', 'Septic shock']

entities_list: @entity3013 :: ('MESH:D060467', 'Disease') :: ['pandrug-resistant', 'PDR']

entities_list: @entity2489 :: ('MESH:D053717', 'Disease') :: ['Ventilator-associated pneumonia', 'A. baumannii VAP', 'VAP']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']

answer: @entity3064 :: (470,Species) :: ['Acinetobacter baumannii']


abstract: There exists an inverse proportionality between number of heat-killed cells of @entity2491 injected intraperitoneally into @entity19 and the quantity of urinary @entity1568 the animals excrete during a 17 hour period following the subcutaneous administration of 2 units of ACTH. This relationship has been developed into an assay for bacterial endotoxin. @entity19 immunized against @entity2491 require 10 to 20 times the number of cells needed by control animals to suppress urinary @entity1568 excretion to the same extent. Intravenous saccharated @entity1933 sensitizes animals so that fewer heat-killed salmonellae can be detected. Heat-killed cells of @entity794 are without effect in the assay. Several lipopolysaccharides derived from Gram-negative bacteria are effective in preventing the rise of urinary @entity1568 excreted in response to ACTH and the amount required, compared to the LD(50), is in the same ratio for all of them. Citrated mouse serum partially inactivates the endotoxin during in vitro incubation for 1 hour at 37 degrees C. while normal serum does not. @entity31965 protects @entity19 against the lethal effects of lipopolysaccharide and it lowers its effectiveness in the assay. The minimum amount of endotoxin reliably determined by the test is 0.25 microg. of an @entity526 preparation that was given intravenously in @entity19 in which the reticuloendothelial system had been "blocked" with saccharated @entity1933 .

title: EFFECTS OF BACTERIAL ENDOTOXINS ON METABOLISM : III. XXXX EXCRETION AFTER ACTH AS AN ASSAY FOR ENDOTOXIN.

entities_list: @entity2491 :: ('90371', 'Species') :: ['S. typhimurium', 'Salmonella typhimurium']

entities_list: @entity31965 :: ('MESH:C084581', 'Chemical') :: ['Dichloroisoproterenol']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

answer: @entity1568 :: (MESH:D009584,Chemical) :: ['NITROGEN']


abstract: PURPOSE: To determine the relative contributions of subjective @entity148 , @entity308 , @entity25 , and @entity410 -related variables to quality-of-life scores in adults with @entity302 , and the interrelationships among these factors. METHODS: Consecutive adult @entity1 with @entity302 attending neurology outpatient clinics were recruited. @entity1 completed the following scales: Hospital Anxiety and @entity308 Scale (HADS), Hamilton Anxiety Rating Scale, Medical Outcomes Study (MOS) Sleep Scale, Epworth Sleepiness Scale, and Quality of Life in Epilepsy Inventory-31 (QOLIE-31). Univariate and multivariate linear regression models were used to identify variables associated with QOLIE-31 overall score. Path analysis model was constructed to test for interrelations between the variables. RESULTS: Two hundred forty-seven @entity1 completed the questionnaires. By multivariate analysis, in order of degree of contribution, HADS @entity148 subscale score, MOS Sleep Scale Sleep Problems Index score, HADS @entity308 subscale score, number of current antiepileptic drugs used, and @entity410 freedom in the past 4 weeks, significantly correlated with QOLIE-31 overall score, accounting for 65.2% of the variance. Complex interrelationships were present between these factors. A general linear model to predict QOLIE-31 overall score in the presence of these factors was constructed. CONCLUSION: Subjective @entity148 , @entity308 , and @entity25 exerted greater effect than short-term @entity410 control on quality of life scores of @entity1 with @entity302 . These factors should be considered simultaneously when evaluating effects of treatment on quality of life.

title: Association of subjective @entity148 , @entity308 , and @entity25 with quality-of-life ratings in adults with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: AIMS AND OBJECTIVE: The negative impact of @entity6008 on quality of life is well documented. The aim of this study was to determine the effectiveness of a new community nursing model of care on quality of life, morale, @entity308 , self-esteem, social support, healing, @entity158 and functional ability of clients with chronic @entity3179 . BACKGROUND: @entity3179 are slow to heal, frequently recur and are associated with @entity158 , restricted mobility and decreased quality of life. Although chronic wound care consumes a large proportion of community nursing time and health care resources, there is little evidence available on the effectiveness of differing models of community care for this population. DESIGN: Randomised controlled trial. METHODS: We recruited a sample of 67 @entity1 with @entity3179 referred for care to a community nursing organisation in Queensland, Australia after obtaining informed consent. @entity1 were randomised to either the Lindsay Leg Club model of care (n = 34), emphasising socialisation and peer support; or the traditional community nursing model (n = 33) consisting of individual home visits by a registered nurse. @entity1 in both groups were treated by a core team of nurses using identical research protocols based on short-stretch compression bandage treatment. Data were collected at baseline, 12 and 24 weeks from commencement. RESULTS: @entity1 who received care under the Leg Club model demonstrated significantly improved outcomes in quality of life (p = 0.014), morale (p < 0.001), self-esteem (p = 0.006), healing (p = 0.004), @entity158 (p = 0.003) and functional ability (p = 0.044). CONCLUSION: In this sample, the evaluation of the Leg Club model of care shows potential to improve the health and well-being of clients who have @entity6008 . RELEVANCE TO CLINICAL PRACTICE: These results suggest further evaluation and implementation of this model is warranted by community health organisations involved in the care of this population.

title: A randomised controlled trial of a community nursing intervention: improved quality of life and healing for clients with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous leg ulcers', 'Venous leg ulcers']

entities_list: @entity6008 :: ('MESH:D007871', 'Disease') :: ['chronic leg ulcers']

answer: @entity6008 :: (MESH:D007871,Disease) :: ['chronic leg ulcers']


abstract: A prospective study of 100 @entity130 @entity1 admitted to the resuscitation room was performed. @entity6676 was confirmed radiologically in 17 @entity1 . The mechanism of injury was blunt @entity130 in 91 @entity1 and penetrating in nine. The mean Injury Severity Score was 17. Of those @entity1 with acute @entity6676 , 13 (76%) had no @entity3511 . @entity6676 was suspected clinically in nine of 17 @entity1 (53%) in whom the diagnosis was confirmed radiologically. Nasogastric tubes were placed in 31 @entity1 . Fifteen @entity1 had a diagnostic peritoneal lavage and nine of these had nasogastric aspiration before the procedure. Of 28 @entity1 secondarily transferred from another hospital, three (11%) had undergone nasogastric intubation before transfer, five (18%) had acute @entity6676 on admission and four (14%) had radiological evidence of @entity358 . Complications associated with acute @entity6676 included @entity548 in six @entity1 (35%), @entity358 in two (12%) and prolonged ileus in one (6%). Placement of a nasogastric tube in the absence of a clear contraindication, either before inter-hospital transfer or soon after admission to the resuscitation room is strongly recommended in the management of the multiply injured @entity1 .

title: Acute XXXX after @entity130 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['gastric haemorrhage']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary aspiration']

entities_list: @entity3511 :: ('MESH:D000007', 'Disease') :: ['abdominal injury']

entities_list: @entity6676 :: ('MESH:D013271', 'Disease') :: ['gastric dilatation', 'Acute gastric dilatation']

answer: @entity6676 :: (MESH:D013271,Disease) :: ['gastric dilation']