abstract: UNASSIGNED: During the @entity4259 assimilation pathway, inorganic @entity38638 and @entity11822 are reduced to form @entity16266 ( @entity16267 ). Tolerance to @entity4259 in plants has long been attributable to minimizing the replacement of @entity462 with @entity16266 , which can result in nonspecific selenoproteins that are potentially misfolded. Despite this widely accepted assumption, there is no evidence in higher plants demonstrating that @entity16266 induces @entity137 by resulting in malformed proteins. In this study, we use @entity4335 to analyze the ubiquitin-proteasome pathway, which is capable of removing misfolded proteins. @entity16267 rapidly increased proteasome activity and levels of ubiquitinated proteins, strongly indicating that @entity16266 induces protein misfolding. Proteasome inhibition increased the amount of @entity4259 in protein in @entity16267 -treated plants. Collectively, these data provide a mechanism that accounts for @entity16267 @entity137 . Additionally, @entity16267 did not cause oxidative stress as judged by examining levels of @entity224 using fluorescent microscopy. Therefore, the cellular response to @entity16267 is different compared to @entity11822 , which was recently shown to increase antioxidant metabolism in response to elevated mitochondrial @entity224 that ultimately impaired proteasome activity. Therefore, plants must contend with two divergent modes of @entity137 during @entity4259 assimilation. @entity11822 can result in oxidative stress, but increased flux of @entity11822 reduction can yield @entity16267 that in turn can cause protein misfolding.

title: Stuck between a ROS and a hard place: Analysis of the ubiquitin proteasome pathway in @entity16266 treated @entity4335 reveals different @entity137 during XXXX assimilation.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity']

entities_list: @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine']

entities_list: @entity4335 :: ('3708', 'Species') :: ['Brassica napus']

entities_list: @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium']

entities_list: @entity16266 :: ('MESH:D017279', 'Chemical') :: ['selenocysteine']

entities_list: @entity11822 :: ('MESH:D018038', 'Chemical') :: ['Selenite', 'selenite']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

answer: @entity4259 :: (MESH:D012643,Chemical) :: ['selenium']


abstract: BACKGROUND: The aim of the study was to evaluate the influence of the pore size of a @entity7502 mesh on the shrinkage and elasticity of the mesh-tissue complex and the inflammatory reaction to the implant in an open onlay hernia repair. MATERIALS AND METHODS: Twenty-one 10     10  cm samples of @entity7502 meshes of a different pore size (3.0     2.8  mm-PP3, 1.0     0.8  mm-PP1 and 0.6     0.5  mm-PP.5) were implanted in an onlay position in 21 New Zealand white @entity95 . After 90  days of implantation the shrinkage, elasticity and @entity6377 ( @entity6377 ) were assessed. RESULTS: The shrinkage of PP3 was 30.6      4.3  %, PP1 49.3      2.9  % and PP.5 49.5      2.6  %. The shrinkage of PP3 was significantly lower (PP3     PP1 p  =  0.007, PP3     PP.5 p  =  0.005), PP1 and PP.5 were similar. The elasticity was similar. The strength of @entity6377 in mesh pores was similar. The width of foreign body @entity738 layers at the mesh-tissue interface was significantly reduced with increasing pore size (inner: PP3 10.1      1.2; PP1 12.5      2.9; PP.5 17.4      5.2 and outer: PP3 21.2      2.5; PP1 30.6      6.3; PP.5 60.4      14.9). All differences between the widths of @entity738 layers were statistically significant (p  <  0.010). One animal (PP1) was excluded because of a @entity281 . CONCLUSIONS: Implantation of @entity7502 mesh of a pore size of 3  mm in an onlay position is associated with a significant reduction of shrinkage in comparison to a 1  mm pore lightweight and 0.5  mm pore heavyweight mesh. A pore size increase to 3  mm is not sufficient for an improvement of mesh-tissue complex elasticity in comparison to a 1  mm pore lightweight and 0.5  mm heavyweight mesh. @entity7502 mesh with enlarged pores to 3  mm is associated with a similar strength of @entity6377 in mesh pores and a @entity6401 in comparison to a 1  mm pore lightweight and 0.5  mm pore heavyweight mesh.

title: Evaluation of three purely @entity7502 meshes of different pore sizes in an onlay position in a New Zealand white XXXX model.

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma']

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['Polypropylene', 'polypropylene']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['mesh infection']

entities_list: @entity6401 :: ('MESH:D015745', 'Disease') :: ['reduced foreign body granuloma']

entities_list: @entity6377 :: ('MESH:D005549', 'Disease') :: ['foreign body reaction', 'FBR']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: BACKGROUND: The safety of high dose inhaled @entity230 has been a subject of debate. The efficacy and safety of @entity2715 and @entity4184 inhalations were evaluated by measuring their effects on pulmonary function, on the @entity1636 , and on @entity1735 metabolism in adults with unstable @entity565 . METHODS: Fifteen adults with unstable @entity565 and 15 healthy controls were studied. Eight @entity1 were treated with @entity2715 in initially high (2 mg/day for five months) and subsequently lower (1 mg/day for three months) doses. Seven @entity1 were treated with @entity4184 at doses of 1.6 mg/day for five months followed by 0.8 mg/day for three months. Blood @entity413 and serum insulin were measured in an oral @entity413 tolerance test and plasma @entity701 in an adrenocorticotrophic hormone test. The antiasthmatic effect of treatment was evaluated by measuring peak morning expiratory flow rates and forced expiratory volume in one second (FEV1). RESULTS: The FEV1 increased significantly after one month of treatment (medians 88% v 96%, p < 0.01), and nocturnal symptoms disappeared within two weeks of treatment in both groups. At one month, the high dose significantly decreased serum insulin concentrations as calculated from the areas under the incremental two hours curves in the @entity413 tolerance test. The decrease was 59% for @entity2715 (medians 76 v 31 mU/l/h, p < 0.005) and 42% for @entity4184 (medians 79 v 46 mU/l/h, p < 0.01). The median areas at five and eight months were intermediate for both drugs. No significant differences were found when the five and eight month values were compared either with the baseline or with one month values. The difference between the baseline values of both groups and the respective values in healthy controls was significant (medians 79 v 49 mU/l/h, p < 0.01). The one month values for the @entity1 and control subjects were similar. Paralleling the changes for insulin, the area under the incremental two hour blood @entity413 curve decreased significantly (medians 1.4 v 0.4 mmol/l/h, p < 0.05) during the first month of treatment. The five and eight month values were intermediate (medians 0.8 and 0.7 mmol/l/h, respectively). These changes were not significant compared with the baseline or the one month areas. Similar changes were seen in both treatment groups. Neither treatment had any significant effect on plasma @entity701 in the one hour adrenocorticotrophic hormone test. CONCLUSIONS: In @entity1 stressed by uncontrolled @entity565 , the antiasthmatic effect of high dose @entity2715 and @entity4184 was accompanied by a significant initial decrease in insulin resistance with a parallel improvement in @entity413 tolerance. During prolonged treatment a small increase in insulin sensitivity was found. The overall effect of @entity2715 and @entity4184 inhalations on @entity1735 metabolism may be beneficial in @entity1 with uncontrolled @entity565 .

title: Effect of eight months of inhaled @entity2715 and XXXX on @entity1735 metabolism in adults with @entity565 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2715 :: ('MESH:D001507', 'Chemical') :: ['beclomethasone dipropionate']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity1636 :: ('MESH:D018268', 'Disease') :: ['hypothalamic-pituitary-adrenocortical axis']

entities_list: @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity4184 :: (MESH:D019819,Chemical) :: ['budesonide']


abstract: PURPOSE: Management of @entity5720 of the breast identified during preoperative tissue diagnosis remains controversial. This study was designed to analyze the clinical factors associated with under-diagnosis of @entity5 in @entity1558 . METHODS: @entity1 with a preoperative tissue diagnosis of benign or atypical @entity5720 , who received surgical excision between 1991 and 2005, were identified. Age of diagnosis, family history of @entity0 , presentation of nipple discharge, palpable mass, mammogram grading, size of lesion, and final pathological diagnosis were analyzed. Tissue sections were reviewed to confirm the diagnosis of @entity5 and reasons of discrepancy. RESULTS: A total of 205 @entity1 with 228 @entity5720 were studied. The median age was 42 (range, 12-83) years. @entity5 were diagnosed after surgery in 21 cases (9.2%). @entity1 aged 45 years or older and atypical lesions according to fine needle aspiration cytology (FNAC) or core needle biopsy (CNB) were associated with higher risk for postoperative malignant diagnosis with P values of 0.0008 and < 0.0001, respectively. Pathology review of 19 lesions with @entity5 revealed that reasons for preoperative nonmalignant diagnosis were @entity75 in nine (47.3%), sampling problem in six (31.5%), interpretation error in three (15.7%) and uninterpretable sample in one (5.2%). CONCLUSIONS: In this cohort, 9.21% of preoperative nonmalignant @entity5720 were converted to malignant diagnosis after surgery. @entity75 and @entity1 aged 45 years or older were significant factors associated with such conversion. Surgical excision should be considered for @entity5720 of breast, especially for @entity1 with the identified risk factors.

title: Risk factors associated with conversion from nonmalignant to malignant diagnosis after surgical excision of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Malignancies', 'malignancy']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Atypical lesions', 'borderline lesions']

entities_list: @entity5720 :: ('MESH:D007681', 'Disease') :: ['papillary lesions']

entities_list: @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast papillary lesions']

answer: @entity1558 :: (MESH:D001941,Disease) :: ['breast papillary lesions']


abstract: BACKGROUND: There is uncertainty in the literature over the relative effectiveness of lumbar epidural interlaminar (IL) @entity134 injection versus transforaminal (TF) @entity134 injection for @entity614 . Most studies to date have been retrospective, or technically focused. OBJECTIVE: To complete a randomized, blinded, prospective outcome study of the short-term benefit for IL versus TF epidural @entity230 for the treatment of subacute @entity158 . STUDY DESIGN: Prospective, randomized, blinded, subacute efficacy trial. SETTING: Tertiary care @entity158 management center, major metropolitan city, United States. METHODS: After institutional review board approval, 42 age-matched @entity1 with similar lower back @entity158 and unilateral radicular symptoms were enrolled and randomized in a @entity1 and evaluating physician blinded trial to IL or TF epidural @entity230 from 2007 through 2009. Prior to intervention and 10-16 days after injection, each @entity1 was evaluated by questionnaire and physical exam by an independent physician. All injections were performed by the same physician. Thirty-eight @entity1 completed the study, 18 in the IL group and 20 in the TF group. Four @entity1 required a repeat injection, and 2 @entity1 crossed over to the alternative injection type (IL to TF). RESULTS: Overall, physical exam, diagnostic testing, disability, activity, @entity308 measures, and opioid pill use were similar between the 2 groups, both pre-injection baseline and post-injection improvement. In primary outcomes, the post-injection follow-up Numeric Rating Scale (NRS) was more greatly reduced in the TF group. The NRS decreased from 7.0    1.9 to 3.9    3.1 (mean values +/- standard deviation) in the IL group and 6.4    2.1 to 1.7    1.4 in the TF group. The @entity717 Index was reduced from 37.5    12.6 to 19.0    16.7 in the IL group and 38.3    6.4 to 21.6    16.8 in the TF group. In secondary outcomes, the @entity308 scale was reduced from 4.39    3.22 to 2.28    3.20 in the IL group and 4.10    1.94 to 1.65    1.63 in the TF group. Walking tolerance was increased from 8.1    4.6 blocks to 10.6    4.4 in the IL group and 8.9    5.3 blocks to 11.8    4.2 in the TF group. LIMITATIONS: The study did not examine long-term outcomes. A single experienced interventionalist performed all injections. CONCLUSION: Results suggest that @entity1 may experience greater subjective relief, at least initially, from TF epidural @entity134 injections over IL. However, more objective, and likely subacute, therapeutic effects are similar.

title: Interlaminar versus transforaminal epidural @entity230 for the treatment of subacute XXXX : a randomized, blinded, prospective outcome study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'participant', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'lumbar radicular pain']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['lumbar radiculopathy']

answer: @entity158 :: (MESH:D010146,Disease) :: ['lumbar radicular pain']


abstract: OBJECTIVE: This study was undertaken to evaluate the use of digital tomosynthesis (tomogram) for diagnosis of suspected @entity2249 (NOF). We hypothesised that the use of cross-sectional imaging (MRI/CT) could be reduced by using tomogram to separate the @entity1 with suspected NOF fractures that require MRI/CT scan from those who do not. MATERIALS AND METHOD: Forty-one @entity1 with a clinically suspected NOF @entity174 , following @entity130 , with negative AP and lateral hip X-rays, underwent a hip tomogram examination. @entity1 with a negative tomogram and clinically moderate to high probability of a @entity173 underwent MRI/CT within 48  h. RESULT: Tomogram identified @entity174 NOF in six @entity1 , who underwent appropriate surgical treatment without needing further imaging. Fifteen @entity1 , with negative tomogram examinations for @entity174 NOF and a low clinical probability of a @entity174 did not undergo additional MRI/CT scanning. At 6  months of follow-up, none of the @entity1 returned to the hospital with complications. Twenty @entity1 with moderate to high clinical probability of @entity174 NOF with negative or inconclusive tomogram underwent additional MRI/CT scanning (19 MRI, 1 CT). Two @entity1 showed @entity174 NOF, and one @entity1 with greater trochanter @entity174 on tomogram showed @entity174 NOF on MRI scan. Seventeen @entity1 showed soft tissue injury, bone @entity4 or pubic rami/acetabular fractures on MRI scan. CONCLUSION: Tomogram is a reliable imaging modality that can be used to select the @entity1 who will need additional MRI/CT scan following negative or equivocal plain X-ray in @entity1 with suspected @entity173 following fall. LEVEL OF EVIDENCE: III.

title: Initial clinical experience of the use of digital tomosynthesis in the assessment of suspected XXXX in the elderly.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['fracture neck of femur']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures', 'hip fracture']

answer: @entity2249 :: (MESH:D005265,Disease) :: ['fracture neck of femur']


abstract: INTRODUCTION: @entity2332 may improve outcome in @entity1 after @entity131 , especially when @entity2332 is maintained for more than 48 hours. In the acute phase, @entity1 with severe @entity1545 are more vulnerable to @entity281 . Prolonged hypothermic treatment may further enhance the risk of @entity281 . Selective decontamination of the digestive tract (SDD) reduces the risk of @entity1729 . The aim of this study was to investigate the incidence of @entity281 in @entity1 treated with @entity2332 and normothermia while receiving SDD. METHODS: In this retrospective case control study 35 @entity1 treated with prolonged @entity2332 (cases) were identified and 169 @entity1 with severe @entity1545 were included (controls). Propensity score matching was performed to correct for differences in baseline characteristics and clinical parameters. Primary outcome was the incidence of @entity281 . The secondary endpoints were the micro-organisms found in the surveillance cultures and @entity281 . In addition, a number of clinical characteristics were assessed. RESULTS: The demographic and clinical data indicated that the cases and controls were well matched. The overall risk of @entity281 during ICU stay was 20% in the @entity2332 groups versus 34.4% in the normothermia group (P = 0.388). @entity55 was diagnosed in 11.4% of @entity1 in both groups (P = 1.000). The incidence of @entity693 , @entity2737 , @entity2259 , and @entity293 was low and comparable between the groups. SDD surveillance cultures indicated a higher colonization with gram-negative bacteria in the rectal samples of the @entity2332 @entity1 . CONCLUSIONS: @entity2332 does not increase the risk of @entity281 in @entity1 treated with SDD.

title: XXXX does not increase the risk of @entity281 : a case control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['Pneumonia']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['wound infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory tract infections']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia', 'Hypothermia']

answer: @entity2332 :: (MESH:D007035,Disease) :: ['Hypothermia']


abstract: Psoriasis is a @entity262 with cutaneous manifestations. MicroRNAs (miRNAs) are small non-coding RNA molecules that are differentially expressed in psoriatic skin; however, only few cell and region specific miRNAs have been identified in @entity75 . We used laser capture microdissection (LCM) and next-generation sequencing (NGS) to study the specific miRNA expression profiles in the epidermis (Epi) and dermal inflammatory infiltrates (RD) of psoriatic skin (N=6). We identified 24 deregulated miRNAs in the Epi and 37 deregulated miRNAs in the RD of @entity5144 compared with normal psoriatic skin (FCH>2, FDR<0.05). Interestingly, 9 of the 37 miRNAs in RD, including @entity35212 and @entity10019 were recently described as deregulated in circulating peripheral blood mononuclear cells (PBMCs) from @entity1 with @entity1569 . Using flow cytometry and qRT-PCR, we found that @entity35212 and @entity10019 were expressed in Th17 cells. In conclusion, we demonstrate that LCM combined with NGS provides a robust approach to explore the global miRNA expression in the epidermal and dermal compartments of psoriatic skin. Furthermore, our results indicate that the altered local miRNA changes seen in the RD are reflected in the circulating immune cells, suggesting that miRNAs may contribute to the pathogenesis of @entity1569 . This article is protected by copyright. All rights reserved.

title: Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that reflect systemic microRNA changes in XXXX .

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['psoriatic lesions']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic plaque']

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: OBJECTIVE: To evaluate the efficacy and tolerability of @entity11711 5 mg and 10 mg nasal spray (ZNS) vs placebo in the acute treatment of @entity2686 . Design/ METHODS: We conducted a multicenter, double-blind, randomized, three-period crossover study using ZNS 5 mg, ZNS 10 mg, and placebo. @entity10 intensity was rated by a 5-point scale: none, mild, moderate, severe, or very severe. The primary efficacy measure was @entity10 response ( @entity158 reduced from moderate, severe, or very severe at baseline, to mild or none) at 30 minutes. Logistic regression was used to account for treatment period effect as well as for @entity2686 subtype effect. RESULTS: A total of 52 adult @entity1 treated 151 attacks. For the primary endpoint, both doses reached significance at 30 minutes (placebo = 30%, ZNS 5 mg = 50%, ZNS 10 mg = 63.3%). For @entity10 relief, ZNS 10 mg separated from placebo at 10 minutes (24.5% vs 10%). @entity11711 5 mg separated from placebo at 20 minutes (38.5% vs 20%). For @entity158 , ZNS 10 mg was superior to placebo at 15 minutes (22.0% vs 6%). Both doses had higher @entity158 -free rates than placebo at 30 minutes (placebo = 20%, ZNS 5 mg = 38.5%, ZNS 10 mg = 46.9%). Side effects were mild and seen in 16% of those attacks treated with placebo, 25% of attacks treated with ZNS 5 mg, and 32.7% treated with ZNS 10 mg. CONCLUSIONS/RELEVANCE: @entity11711 nasal spray, at doses of 5 and 10 mg, is effective and tolerable for the acute treatment of @entity2686 .

title: XXXX nasal spray in the acute treatment of @entity2686 : a double-blind study.

entities_list: @entity11711 :: ('MESH:C089750', 'Chemical') :: ['Zolmitriptan', 'zolmitriptan']

entities_list: @entity2686 :: ('MESH:D003027', 'Disease') :: ['cluster headache']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain-free status', 'pain']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']

answer: @entity11711 :: (MESH:C089750,Chemical) :: ['Zolmitriptan']


abstract: Computed tomography (CT) has emerged from the 1980s to play a dominant role in the pretreatment staging of @entity703 . For detection, definition (staging), and determination of resectability or recurrence, CT with intravenous contrast enhancement, and more recently, magnetic resonance imaging (MRI) with @entity2287 - @entity12306 , may be the only cross-sectional imaging studies required before institution of appropriate therapy. @entity703 is frequently diagnosed by serendipity or detected on incidental ultrasound or CT examinations. Real-time ultrasound and color flow Doppler offer unique information on @entity5 vascularity and major venous vascular involvement. Positive predictive values of 96% can be achieved for the diagnosis of @entity1358 using contrast-enhanced CT scanning. For follow-up CT and MRI are the best imaging techniques for evaluation of the retroperitoneum. MRI may distinguish @entity5 recurrence from @entity82 in selected cases. Because primary @entity5 of the adrenal gland are rare and often exceed 10 cm at the time of initial diagnosis, the functional nature (endocrine) of @entity4304 may be part of the clinical presentation. Because initial stage is critical to survival and extent of surgical therapy, a knowledge of @entity5 classification is essential to the optimal diagnostic evaluation. Newer imaging tests, CT and MRI, have superseded conventional urography, ultrasound, and radionuclide studies for the diagnosis and @entity5 . Early diagnosis and low stage at presentation are critical to survival in @entity1 with @entity4304 . The current concepts for pretreatment imaging evaluation and the role of CT, MRI, and ultrasound are outlined. An oncologic imaging approach based on @entity5 staging and classification for @entity1 with real or suspected @entity1358 and @entity4304 is essential to optimal @entity1 care.

title: Oncologic imaging. Staging and follow-up of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'staging of adrenal cancer', 'neoplasms']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['Carcinoma of the kidney', 'renal and adrenal carcinomas']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity4304 :: ('MESH:D000310', 'Disease') :: ['adrenal carcinoma']

answer: @entity703 :: (MESH:D007680,Disease) :: ['renal and adrenal carcinoma']


abstract: The pathophysiology of @entity63 @entity299 is multifaceted. @entity731 , @entity2473 , @entity715 , and @entity887 , alone and in combination, play a role in the pathogenesis of @entity741 . The effect of @entity1563 may vary from @entity1 to @entity1 , producing stable or unstable @entity951 , or @entity583 . @entity741 occurs when there has been an acute imbalance between @entity26 demand and supply. A number of variables alter the relationship between the presence of @entity741 and the degree of @entity3979 . These include the length, location, and geometry of the @entity850 ; the presence or absence of collateral vessels; and the coronary arterial tone. Coronary arteriography has shown the same general extent and distribution of @entity453 in @entity1 with stable and unstable @entity951 . Differences in the severity of @entity453 emerge when the various forms of unstable @entity951 are considered separately. More severe @entity301 is present in @entity1 who present with a crescendo pattern of @entity951 and in those who display either @entity1347 or T-wave inversions during @entity662 . The precise mechanism for the production of unstable @entity951 in any individual @entity1 is unknown but may be related to several factors, including the rapid progression of @entity453 just before or during the onset of unstable @entity951 ; or intermittent transient @entity1563 resulting from @entity2473 , @entity1423 , or @entity715 .

title: Presence and evolution of XXXX in relation to clinical and electrocardiographic patterns of @entity741 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease']

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['ST-segment deviations']

entities_list: @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusive disease', 'coronary artery occlusion']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris', 'angina']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['Myocardial ischemia', 'myocardial ischemia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary atherosclerosis']


abstract: @entity6887 ( @entity6887 ) is the rarest gynecologic @entity5 . We present the first documented case of this rare @entity5 in Ethiopia, in a 50 years old perimenopausal @entity1 . The @entity1 complained of irregular menses, on and off vaginal discharge and longstanding lower @entity490 . She had longstanding @entity249 for which she did not seek medical help. The @entity1 was subjected for laparotomy with the preoperative diagnosis of @entity4134 . Huge bilateral hydrosalpinges were found with pelvic adhesions involving the ovaries. Total hysterectomy with bilateral adnexectomy was performed following adhesiolysis. The diagnosis of low-grade papillary tubal @entity189 was made postoperatively when the specimen from total abdominal hysterectomy and bilateral salpingoopherectomy was examined histologically. The @entity1 declined relaparatomy for proper staging or further adjuvant treatment. She was free of clinically demonstrable recurrence five months after discharge. Challenges in the detection of @entity6887 relating to its signs and symptoms, diagnostic difficulties, choice of treatment and factors that may influence survival are outlined It is prudent to perform histopathologic examination on all surgically excised specimens however obvious the clinical findings appear to be.

title: @entity6887 ( @entity6887 ) comorbidity with XXXX and bilateral hydrosalpinx.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'neoplasm']

entities_list: @entity6887 :: ('MESH:D005185', 'Disease') :: ['Primary fallopian tube carcinoma', 'PFTC']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity4134 :: ('MESH:D000292', 'Disease') :: ['chronic pelvic inflammatory disease']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertility']


abstract: Conservative radio-surgical treatment of @entity0 is often responsible for poor cosmetic results when the @entity5 is located in the lower quadrants. Since 1986, ten @entity1 with such a @entity5 were treated at the Curie Institute by a combination of a superior pedicle mammaplasty and radiotherapy. The mammaplasty was bilateral in nine cases. Four @entity1 were operated upon before radiotherapy, while the six others had preoperative radiotherapy. The average weight of the lumpectomy was 193 g, and its margins were always @entity5 -free. There were no locoregional recurrences (average follow-up time: 16 months). Symmetrization enabled us to obtain contralateral histological data. The cosmetic results were very good when surgery was performed before radiotherapy. When radiotherapy was performed first, the result was often slightly asymmetric, with a smaller irradiated breast. The only complication was @entity39 in one @entity1 who had been heavily irradiated (85 grays). The combination of a mammaplasty and radiotherapy makes it possible to perform a large lumpectomy of the lower quadrants with good cosmetic results. The interest of this protocol in the extension of the indications for conservative treatments of @entity0 is discussed.

title: [Mammoplasty combined with irradiation: conservative treatment of XXXX localized in the lower quadrant].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast neoplasms']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['partial areolar necrosis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: A novel family of small proteins, termed @entity7817 .5 or YERO57c/YJGFc, has been identified. Independent studies indicate that @entity7817 .5 family members are multifunctional proteins involved in several pathways, e.g. regulation of translation or activation of the protease mu-calpain. We have previously shown that @entity62119 , a @entity7817 .5 of the budding @entity375 @entity375 , is localized in the mitochondria and influences mitochondrial DNA stability. In addition, we have demonstrated that @entity62119 is functionally related to @entity7817 .5 of @entity1 cells. To explore further the evolutionary conservation of the mitochondrial function(s) of the @entity7817 .5s we have extended our study to the @entity6739 , @entity6739 . In this organism two @entity7817 .5 homologous proteins are present: Pmf1p (pombe mitochondrial factor 1) and @entity62120 (homologous Pmf1p factor 1). We have generated a specific Pmf1p antibody, which recognizes a single band of approximately 15 kDa in total cellular extracts. Cellular fractionation experiments indicate that Pmf1p localizes in the mitochondria as well as in the cytoplasm. We also show that Pmf1p shares several properties of @entity375 @entity62119 . Indeed, Pmf1p restores the wild-type phenotype when expressed in delta @entity62119 @entity375 cells. Deletion of the leader sequence of Pmf1p abrogates its ability to localize in mitochondria and to functionally replace @entity62119 . Thus, these data together with our previous study show that the mitochondrial function(s) of the @entity7817 .5 family members are highly conserved in eukaryotic cells.

title: @entity6739 Pmf1p is structurally and functionally related to XXXX of @entity375 .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity6739 :: ('4896', 'Species') :: ['Schizosaccharomyces pombe', 'fission yeast']

entities_list: @entity375 :: ('4932', 'Species') :: ['S. cerevisiae', 'yeast', 'Saccharomyces cerevisiae']

answer: @entity62119 :: (854760(Tax:4932),Gene) :: ['Mmf1p']


abstract: @entity320 @entity1 were injected with various vaccines containing a @entity5840 peptide presented by HLA- @entity6293 . Anti- @entity5840 . @entity6293 T cells were not detectable in the blood before vaccination, but their frequencies after vaccination ranged from 2 x 10(-6) to 2 x 10(-3) among the @entity404 (+) blood T lymphocytes of the @entity1 . The @entity404 (+) blood T lymphocytes that stained ex vivo with HLA- @entity6293 tetramers folded with the @entity5840 peptide were selected by flow cytometry and amplified under clonal conditions. About 5% of the @entity404 (+) T-cell clones that recognized the @entity5840 . @entity6293 antigen had a @entity2902 (+) phenotype in the resting state. These @entity2902 (+) clones had a high capacity to suppress the proliferation of another T-cell clone after peptide stimulation in vitro. Most of them had high @entity403 expression in the resting state and an unmethylated @entity403 intron 1. They produced active transforming growth factor-beta but none of cytokines @entity379 , @entity1199 ( @entity1199 ), @entity3646 , @entity225 , and @entity688 . About 20% of @entity2902 (-) clones had a significant but lower suppressive activity. Most of the @entity2902 (-) clonal populations contained cells that expressed @entity403 in the resting state, but @entity403 demethylation was not observed. We conclude that @entity5840 . @entity6293 vaccination can produce @entity404 (+) T cells that may exert regulatory T-cell function in vivo.

title: The XXXX (+) T-cell response of @entity320 @entity1 to a @entity5840 peptide vaccine involves potential regulatory T cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['Melanoma']

answer: @entity404 :: (920,Gene) :: ['CD4']


abstract: UNASSIGNED: Acute and chronic changes in ambient temperature alter several aspects of reptilian physiology. We investigated the effects of each type of temperature change on reptilian cardiovascular regulation in @entity8308 ( @entity8308 ), a species known to experience marked seasonal changes in ambient temperature. Turtles were instrumented with occlusive catheters in the femoral artery and vein. Following an acclimation period of 10  days at @entity7352 (131), cardiovascular responses to @entity1425 , and the cardiac limb of the baroreflex were quantified. Ambient temperature was then reduced 1    C  day(-1) until 3    C was reached (31). Turtles were maintained at this temperature for 1-week before cardiovascular responses were reassessed. Turtles were then gradually (1    C  day(-1)) returned to an ambient temperature of 13    C, (132). After a 1-week re-acclimation period, cardiovascular responses were again determined. Finally, 1-week post-pharmacological manipulation of turtles in the 132 treatment, ambient temperature was reduced to 3    C over 24  h (32), and cardiovascular responses were again assessed. Temperature reduction from 131 to 31 decreased mean arterial blood pressure (P m) and heart rate (f H) by ~38 and ~63  %, respectively. Acute temperature reduction, from 132 to 32, decreased f H similarly, ~66  %; however, while P m decreased ~28  %, this was not significantly different than P m at 132. The @entity1425 injections increased f H ranging from 90 to 170  % at 13    C which was a greater change than that observed at 3    C ranging from a 40 to 70  % increase. The increase in P m at the lowest dose of @entity1425 did not differ across the temperature treatment groups. The operational point (set-point) P m of the baroreflex was decreased similarly by both methods of temperature reduction (31 or 32). Further, a @entity101 cardiac baroreflex was absent in the majority of the animals studied independent of temperature. Baroreflex gain and normalized gain based on individual estimates of the relationship were decreased by temperature reduction similarly. Collectively, the data suggest that @entity8308 modulate (down-regulate) some cardiovascular control mechanisms during reduced ambient temperature.

title: Acute and chronic temperature effects on cardiovascular regulation in the @entity8308 ( XXXX ).

entities_list: @entity8308 :: ('34903', 'Species') :: ['Trachemys scripta', 'red-eared slider turtles']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

answer: @entity8308 :: (34903,Species) :: ['Trachemys scripta']


abstract: @entity941 angiography of the angle with the Goldmann gonioscopy lens was used to examine eyes of 100 Japanese @entity1 with @entity6 . Ocular tension was 21 mmHg or over in 31 of these 100 @entity1 . Gonioscopy revealed @entity5513 in the eyes of 30 @entity1 ; however, @entity941 gonioangiography showed evidence of @entity5513 in 56 of the 100 @entity1 . Angle neovascularsation was first seen 20.3 +/- 4.1 s after injection of @entity941 dye. Of the newly formed vessels, the branching small vessels showed more prominent leakage than the larger vessels at the root. With progression of the @entity989 , @entity5513 became more severe. Following panretinal photocoagulation in 26 of the @entity1 with @entity2297 , @entity5513 remarkably regressed in 12 and moderately regressed in 7 @entity1 . Ocular tension became normal in 13 @entity1 . Two of 31 @entity1 with ocular @entity101 were considered as cases of primary @entity1538 as there was glaucomatous cupping, @entity227 and no evidence of newly formed vessels in the angle, as observed using @entity941 gonioangiography. Thus, @entity941 gonioangiography may be helpful in the diagnosis and clinical management of @entity2297 .

title: @entity941 gonioangiography in XXXX .

entities_list: @entity5513 :: ('MESH:D009464', 'Disease') :: ['angle neovascularisation']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defects']

entities_list: @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein', 'fluorescein']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity2297 :: ('MESH:D015355', 'Disease') :: ['neovascular glaucoma']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic neovascularisation']


abstract: OBJECTIVE: To explore the links between @entity245 - @entity71 ( @entity71 ) and @entity72 ( @entity72 ) - and @entity1314 in a population-based, genetically sensitive study of @entity1 . METHOD: A population-based sample of 1886 twins aged 9 and 12, enriched for childhood mental health problems, was recruited from the @entity1 and Adolescent Twin Study in Sweden (CATSS). Parents were interviewed over the telephone using the Autism-Tics, @entity195 / @entity2033 and other Comorbidities (A-TAC) inventory, and in a second step they rated their @entity1 according to the Junior Temperament and Character Inventory (JTCI). RESULTS: @entity71 was strongly correlated with novelty seeking, while @entity72 was correlated positively with harm avoidance and negatively with reward dependence. The strongest associations between @entity1314 traits and @entity245 were negative correlations between the character dimensions of self-directedness and cooperativeness and @entity71 and @entity72 alike. Cross-twin cross-trait correlations between @entity71 , @entity72 , and @entity1314 dimensions in monozygotic twins were more than double those in dizygotic twins, indicating a strong genetic effect behind the phenotypic covariation between @entity245 and @entity1314 . CONCLUSIONS: @entity245 are linked specifically to particular temperament profiles and generally to hampered development of the self-governing strategies referred to as "character." Poor self-agency and cooperation may be core functional outcomes in the separation of @entity1 with handicapping conditions from those with traits only reminiscent of @entity245 . The associations between @entity245 and @entity1314 are at least partly due to genetic effects influencing both conditions. As a consequence, @entity1314 must be broadly considered in neuropsychiatry, just as @entity146 and their genetic, neurodevelopmental, and cognitive susceptibilities have to be in @entity1314 research and clinical treatment.

title: XXXX , @entity72 , temperament, and character: phenotypical associations and etiology in a Swedish childhood twin study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric disorders']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention deficit hyperactivity disorder']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['neurodevelopmental disorders', 'Neurodevelopmental disorders']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality']

answer: @entity71 :: (MESH:D001289,Disease) :: ['ADHD']


abstract: PURPOSE: To report the 6-month comparative outcomes and @entity4530 morphology for needle revision with bevacizumab and @entity1138 ( @entity1139 ) versus @entity1139 alone of failed trabeculectomy and ExPRESS shunt blebs. METHODS: @entity1 undergoing @entity4530 needle revision procedures were enrolled in this study. All @entity1 received a subconjunctival injection of 0.1 mL @entity1139 (0.4 mg/mL) mixed with 0.1 mL preservative-free @entity3303 (1%) at the beginning of the procedure. The @entity1 were randomized into 2 cohorts assigned to receive either 1.0 mg (0.04 mL of 25 mg/mL) subconjunctival bevacizumab (treatment group) or 0.04 mL of balanced salt solution (control group) injected in an identical manner posterior to the @entity4530 after the @entity4530 needling. Success was defined as >= 20% reduction in intraocular pressure (IOP) without any IOP-lowering medications. Qualified success was defined as >= 20% reduction of IOP with IOP-lowering medications. Failure was defined as IOP>21 mm Hg, IOP reduction <20%, or need for additional surgery. Bleb morphology was classified using the Indiana Bleb Appearance Grading Scale. RESULTS: Six months postoperatively, in treatment group (n=29), 57% of @entity1 achieved complete success, and 43% failed. In control group (n=29), 41% of @entity1 achieved complete success, 7% achieved qualified success, and 52% failed. The difference in success rates between the 2 groups was not statistically significant (P=0.35). At 6 months, the mean IOP was 11.52 in treatment group and 12.83 in control group (P=0.45); @entity1 in treatment group were on a mean of 0.16 medications as compared with 0.58 medications in control group (P=0.058). For @entity4530 morphology of treatment group compared with control group, the blebs had less vascularity (0.76 vs. 1.20, respectively, on a scale of 0 to 4, P<0.05) and greater extent (2.68 vs. 2.36, on a scale of 0 to 3, P=0.022) in treatment group. CONCLUSIONS: There was no significant difference between the success rates and IOPs at postoperative month 6 between treatment and control groups. @entity86 in the treatment group were less vascular and had greater extent.

title: Needle Bleb Revision With Bevacizumab and @entity1138 Compared With XXXX Alone for Failing Filtration Blebs.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['Postoperative blebs']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['Mitomycin C']


abstract: BACKGROUND: @entity9440 is a very rare event complicating pregnancy. Approximately 5% of cases reported have involved the postpartum period. Unrecognized, this complication is universally fatal. CASE: Preeclampsia and @entity3126 complicated a 42-year-old @entity1 's intrapartum care. After cesarean delivery she was supported with mechanical ventilation, blood products and invasive monitoring. Shortly thereafter, she became @entity551 and developed disseminated @entity5642 . During exploratory laparotomy a splenic capsular @entity397 was identified. Splenectomy and continued intensive care support ultimately reversed the severe end-organ consequences. CONCLUSION: It is extremely important that this condition be maintained in the diagnostic differential of post-operative hemodynamic instability. Failure to identify it is invariably fatal. Awareness and intervention are essential to ensure a good outcome.

title: XXXX associated with severe preeclampsia. A case report.

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

entities_list: @entity9440 :: ('MESH:D013161', 'Disease') :: ['Splenic rupture']

answer: @entity9440 :: (MESH:D013161,Disease) :: ['Splenic rupture']


abstract: @entity36808 (Tp5) was loaded in @entity19013 ( @entity16709 ) nanoparticles (NP) in order to enhance the oral bioavailability of Tp5. @entity16709 -Tp5-NP was prepared by nanoprecipitation methods. Dialyzing membrane method was employed to examine the in vitro release of @entity16709 -Tp5-NP in PBS, and Tp5 samples in the release medium were detected by HPLC. The cell proliferation test @entity665 was conducted to verify the @entity16709 -Tp5-NP bioactivity in vitro. The pharmacodynamical studies were performed on preimmunoinhibited @entity35 and in flow cytometer. The size and the entrapment efficiency of @entity16709 -Tp5-NP were 178 +/- 39 nm and 92.21 +/- 1.08%, respectively. In vitro release data show that less than 60% Tp5 was released from lyophilized @entity16709 -Tp5-NP while 80% Tp5 was released from the colloidal @entity16709 -Tp5-NPs in 48 h. The proliferation test showed that @entity16709 -Tp5-NP had the similar effect as Tp5. The in vivo data showed that oral @entity16709 -Tp5-NPs had similar function as what intravenous Tp5 did. The oral bioavailability of Tp5 could be enhanced by @entity16709 nanoparticles. @entity16709 -Tp5-NP had the property of sustained-release and the efficacy of Tp5 was not changed after formulation.

title: Preparation and evaluation of XXXX nanoparticles for oral delivery of @entity36808 .

entities_list: @entity19013 :: ('MESH:D004659|MESH:C049456', 'Chemical') :: ['poly-butylcyanoacrylate']

entities_list: @entity36808 :: ('MESH:D016305', 'Chemical') :: ['Thymopentin']

answer: @entity19013 :: (MESH:D004659|MESH:C049456,Chemical) :: ['poly-butylcyanoacrylate']


abstract: Developing countries bear more than half of the @entity5 comprises of 3% of all @entity5 with an incidence of 300,500 per year. The patterns of subtypes of @entity1778 vary in different populations and geographic areas. Here, we analyze both the hematological and @entity1583 in the Western region of Nepal. This is a retrospective study done from Janauary 2000 to June 2011. All cases of bone @entity236 including @entity1778 , @entity1582 and infiltration/metastasis to @entity236 were included in the study. Morphological subtypes { @entity1334 (French, American and British) classification}, gender, age at diagnosis and peripheral blood counts of all the cases were analyzed. A total of 155 cases of hematological and @entity1583 were reported during this period. Age ranged from 1 year to 82 years. Among 123 @entity1778 cases, @entity3052 ( @entity3052 ) was the commonest (80 cases) followed by @entity1860 ( @entity1860 ) (20 cases), @entity981 ( @entity981 ) (16 cases) and @entity706 ( @entity706 ) (7 cases). The commonest childhood @entity1778 below 15 years was @entity3052 followed by @entity981 . The commonest subtypes of @entity3052 and @entity981 were M2 and L2 respectively. @entity1860 cases in our study were less common and females were more affected than other parts of the country. There were 23 cases of @entity1582 and 9 cases of infiltration/metastasis to marrow. Males were more affected by @entity1582 in our study. Our data reflects bone @entity236 in the Western region of Nepal which is more comparable to the Central than Eastern region of Nepal.

title: Patterns of hematological and @entity1583 in XXXX in a tertiary care hospital in Nepal--11 years study.

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoid leukemia', 'ALL']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['chronic lymphoid leukemia', 'CLL']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['global cancer burden and the leukemia', 'malignancies']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemias', 'leukemia']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['non-hematological malignancies']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow', 'marrow malignancies']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myeloid leukemia']

answer: @entity236 :: (MESH:D001855,Disease) :: ['bone marrow']


abstract: OBJECTIVE: The aim of this study was to investigate the therapeutic response and @entity137 of intensity-modulated radiation therapy (IMRT) or conventional radiotherapy (c-RT) as adjuvant therapy in @entity1 with pelvic locoregional recurrence of @entity5 after radical surgery. METHODS: This retrospective study included 161 @entity1 with unresectable pelvic locoregional recurrence of @entity5 after radical surgery between March 2003 and May 2012. All @entity1 were initially diagnosed with International Federation of Gynecology and @entity5 and received radical hysterectomy and pelvic lymphadenectomy. A total of 82 @entity1 were treated with c-RT, whereas the remaining 79 @entity1 underwent IMRT. Intracavitary brachytherapy and concurrent chemotherapy were performed during external irradiation. RESULTS: The mean dose delivered to the planning target volume was significantly higher in the IMRT group than in the c-RT group (61.8 vs 50.3 Gy, P = 0.029). Intensity-modulated radiation therapy plans yielded better dose sparing of small bowel, bladder, and rectum than did c-RT (P < 0.05). Moreover, the IMRT @entity1 experienced less acute and chronic @entity137 (P < 0.05) and better short-term effects (complete response + partial response) than did those treated with c-RT (89.9% vs 63.4%, P = 0.03). Three- and 5-year overall survival rates were significantly higher in the IMRT group than in the c-RT group (3-year: 58.4% vs 39.1%, P = 0.012; 5-year: 35.4% vs 21.4%, P = 0.007). Furthermore, 5-year progression-free survival rates were significantly higher in the IMRT group than in the c-RT group (26.1% vs 15.1%, P = 0.031). CONCLUSIONS: Intensity-modulated radiation therapy achieved outcomes superior to c-RT in @entity1 with pelvic locoregional recurrence of @entity5 after radical surgery. The acute and chronic @entity137 were acceptable, and the adjacent organs at risk were well protected.

title: The Treatment of Pelvic Locoregional Recurrence of XXXX After Radical Surgery With Intensity-Modulated Radiation Therapy Compared With Conventional Radiotherapy: A Retrospective Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Obstetrics stage IB-IIA cervical cancer', 'cervical cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cervical Cancer']


abstract: BACKGROUND: Little information is available on Asian @entity1 over 80 years with @entity64 . We aimed to investigate characteristics of the very elderly @entity385 hospitalized @entity1 in China. METHODS: We prospectively enrolled consecutive @entity1 with acute @entity385 from March, 2002 to October, 2008 into the analysis. @entity1 were divided into two groups: <80 years versus >= 80 years and risk factors, hospital management and one-year outcome were compared. RESULTS: Of the 2619 cases included, 302 (11.5%) @entity1 were 80 years or older. Compared with @entity1 <80 years, @entity1 over 80 years old had higher rates of @entity101 (66.2% versus 56.1%, p=0.001), @entity955 (23.5% versus 14.5%, p=0.000), and @entity301 (13.6% versus 5.7%, p=0.000). In addition, they were less likely to have received transthoracic echocardiography (45.4% versus 55.4%, p=0.001), color Doppler of extracranial vessels (54.0% versus 61.2%, p=0.015), antiplatelet agents (80.8% versus 86.8%, p=0.004), or anticoagulants (4.0% versus 9.0%, p=0.003). After adjusting for sex and @entity64 severity on admission, the very elderly @entity1 had higher case-fatality and disability rates at one year (33.8% versus 13.2%, p=0.000; 37.8% versus 20.9%, p=0.000; respectively). CONCLUSIONS: In China, the proportion of the very elderly in hospitalized @entity64 population is lower than that in western countries whereas the most common risk factors seem similar. The hospital management for these @entity1 is relatively insufficient and the long-term outcome is generally unfavorable compared with @entity1 under 80 years old.

title: Acute XXXX in the very elderly Chinese: risk factors, hospital management and one-year outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: According to National Census, there were 1541 @entity1 over the age of 100 years (centenarians) in Poland, in 2002, including 1215 females and 326 males. The aim of the present study was to assess the prevalence of @entity565 , @entity566 , and @entity1576 in centenarians included in the Polish Centenarians Program, POLSTU 2001, conducted between 2001 and 2004. The study group consisted of 301 subjects including 258 females and 43 males. Research data were gathered in a questionnaire designed exclusively for the study, completed by the interviewer during meetings with the subjects and their families. According to the medical history reported by the subjects, 10 @entity1 (3.3%) suffered from @entity565 and 41 (13.6%) from @entity566 . There were no subjects with childhood onset @entity565 . @entity566 to food and medicinal products was the most prevalent. One in four centenarians reported @entity1353 and one in eight complained of cough. When analyzed in relation to gender, cough was more prevalent in males, which might have been related to cigarette smoking. @entity1576 are frequent in elderly populations, but symptoms may be underreported, especially in the situation of coexisting medical problems. Moreover, it might be difficult to perform full diagnostic procedures in the very elderly due to disability, @entity73 , and technical problems. Thus, medical care for the aged should be based on thorough medical evaluation supported by the medical history and reliable information on physician-diagnosed diseases.

title: Asthma, XXXX , and @entity1576 in centenarians living in Poland.

entities_list: @entity1 :: ('9606', 'Species') :: ['people', 'persons']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'Allergy']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory symptoms', 'Respiratory disorders']

answer: @entity566 :: (MESH:D006967,Disease) :: ['allergy']


abstract: @entity8314 is a @entity395 caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen ( @entity6540 ) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose @entity1 have @entity8314 and @entity299 , mainly @entity6015 . The objective of this study was to identify putative @entity6540 / @entity6539 ) epitopes associated with neonatal @entity6015 . The reactivity of IgG antibodies present in the sera from mothers with @entity1252 and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using @entity6540 , @entity6539 and 48-kDa @entity6016 antigen proteins, as well as 45 synthetic peptides, 13-24 residues long, of @entity6540 / @entity6539 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sj  gren's syndrome and asymptomatic mothers of group I, who had at least one @entity1 with @entity8314 , and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to @entity6540 peptides 107-122 and 277-292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with @entity6540 peptides 1-13, 277-292 and 365-382. Antibodies to @entity6540 peptide 365-382 have been shown previously to cross-react with residues 165-185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these @entity6540 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to @entity6540 peptides 1-13, 107-122, 277-292 and 365-382 may therefore represent important biomarkers to predict a complication in pregnant lupus @entity1 with @entity6540 antibodies.

title: 52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of @entity1 with neonatal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'infant']

entities_list: @entity8314 :: ('MESH:C536397', 'Disease') :: ['Neonatal lupus erythematosus', 'neonatal lupus']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ["systemic lupus erythematosus and Sj  gren's syndrome"]

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac conduction disturbances']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']

entities_list: @entity6015 :: ('MESH:C535758', 'Disease') :: ['lupus and congenital heart block', 'congenital heart block']

answer: @entity6015 :: (MESH:C535758,Disease) :: ['lupus and congenital heart block']


abstract: The clinical efficacy of percutaneous transluminal angioplasty and intra-arterial @entity3302 infusion for treatment of @entity2553 following @entity510 was investigated. Between 1990 and 1993, 84 @entity1 were treated for @entity2553 in National Defense Medical College Hospital. Angioplasty was performed for asymptomatic @entity2553 in 18 @entity1 and for symptomatic @entity2553 in 12 @entity1 . Intra-arterial @entity3302 infusion was performed for asymptomatic @entity2553 in 10 @entity1 and for symptomatic @entity2553 in four @entity1 . The other 40 @entity1 were treated with standard conservative therapy including hypervolemic and @entity101 hemodilution. The outcomes of these @entity1 were analyzed using the Glasgow Outcome Scale. The outcome tended to be better for @entity1 treated with angioplasty, but not for those treated with @entity3302 infusion, than for those treated conservatively. Recurrence of @entity2553 was more frequent after @entity3302 infusion than after angioplasty. Undesirable complications such as abrupt development of unconsciousness were experienced during @entity3302 infusion but not during angioplasty. We conclude that percutaneous transluminal angioplasty is superior to intra-arterial @entity3302 infusion for prevention and treatment of @entity2553 following @entity510 .

title: Clinical evaluation of the effect of percutaneous transluminal angioplasty and intra-arterial XXXX infusion for the treatment of @entity2553 following @entity510 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'subarachnoid hemorrhage']

entities_list: @entity3302 :: ('MESH:D010208', 'Chemical') :: ['papaverine']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['cerebral vasospasm', 'vasospasm']

answer: @entity3302 :: (MESH:D010208,Chemical) :: ['papaverine']


abstract: UNASSIGNED: Demineralization in dentinal @entity1547 and @entity2681 exposes dentine organic matrix. This exposed matrix, containing type I collagen and non-collagenous proteins, is then degraded by host collagenolytic enzymes, matrix metalloproteinases (MMPs) and @entity462 cathepsins. The knowledge of the identities and function of these enzymes in dentine has accumulated only within the last 15 years, but has already formed a field of research called 'dentine degradomics'. This research has demonstrated the role of endogenous collagenolytic enzymes in @entity1547 and @entity2681 development. In demineralized dentine, the enzymes degrade triple-helical collagen molecules, leading to the gradual loss of collagen matrix. Even before that, they can cleave off the terminal non-helical ends of collagen molecules called telopeptides, leading to the structural changes at the intramolecular gap areas, which may affect or even prevent intrafibrillar remineralization, which is considered essential in restoring the dentine's mechanical properties. They may also cause the loss of non-collagenous proteins that could serve as nucleation sites for remineralization. Here we review the findings demonstrating that inhibition of salivary or dentine endogenous MMPs and @entity462 cathepsins may provide preventive means against the progression of @entity1547 or @entity2681 . Furthermore, we also suggest the future directions for the new experimental preventive research to gain more knowledge of the enzymes and their function during and after dentine demineralization, and the pathways to find the clinically acceptable means to prevent the functional activity of these enzymes.    2015 S. Karger AG, Basel.

title: Role of Host-Derived Proteinases in Dentine Caries and XXXX .

entities_list: @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine']

answer: @entity2681 :: (MESH:D014077,Disease) :: ['Erosion']


abstract: BACKGROUND: @entity1030 frequently leads to disability. Older @entity1 may experience transitions between states of disability and independence over time. OBJECTIVE: To identify factors associated with transition between states of disability and independent function in @entity3885 . METHODS: We analyzed data on 4,394 @entity1 in the Cardiovascular Health Study who completed prebronchodilator spirometry. We calculated the 1-year probability of developing and resolving impairment in >= 1 instrumental activity of daily living (IADL) or >= 1 activity of daily living (ADL) using transition probability analysis. We identified factors associated with resolving disability using relative risk (RR) regression. RESULTS: The prevalence of @entity73 was higher with moderate (23.9%) and severe (36.9%) @entity1030 compared to normal spirometry (22.5%; p < 0.001). Among @entity1 with severe @entity1030 , 23.5% recovered independence in IADLs and 40.5% recovered independence in ADLs. In the adjusted analyses, @entity1030 predicted the development of IADL, but not ADL impairment. @entity1 with severe @entity1030 were less likely to resolve @entity73 [RR 0.67 and 95% confidence interval (CI) 0.49-0.94]. Compared to the most active individuals (i.e. who walked >= 28 blocks per week), walking less was associated with a decreased likelihood of resolving @entity73 (7-27 blocks: RR 0.81 and 95% CI 0.69-0.86 and <7 blocks: RR 0.73 and 95% CI 0.61-0.86). Increased strength ( @entity4736 .16 and 95% CI 1.05-1.29) was associated with resolving @entity73 . CONCLUSIONS: Disability is common in older @entity1 , especially in those with severe @entity1030 . Increased physical activity and muscle strength are associated with recovery. Research is needed on interventions to improve these factors among @entity1 with @entity3885 and disability.    2014 S. Karger AG, Basel.

title: Disability and recovery of independent function in XXXX : the cardiovascular health study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['IADL impairment']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['obstructive lung disease']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['airflow obstruction', 'Chronic obstructive lung disease']

answer: @entity3885 :: (MESH:D008173,Disease) :: ['obstructive lung disease']


abstract: PURPOSE: To evaluate the efficacy of topical @entity1138 for extensive recurrent conjunctival and @entity957 ( @entity6461 ). DESIGN: Interventional case series. METHODS: A prospective study was conducted in a single institution. Ten @entity1 (ten eyes) with extensive recurrent conjunctival and corneal @entity6461 were studied. The @entity1 received topical @entity1138 0.04% one drop four times daily in the eye with @entity6461 . Treatment cycles were defined as 1 week using medication followed by 1 week without medication. Such treatment cycles were repeated until resolution of the @entity5 was clinically evident. The main outcome measures were @entity5 response and medication-related complications. RESULTS: Of the ten @entity1 , the median age was 66 years (range 33-77 years). Before referral, the @entity1 had undergone a median of two previous @entity5 resections revealing the diagnosis of in situ @entity6461 in three cases and locally invasive @entity6461 in six cases. At presentation, the @entity5 involved the limbus and @entity267 in all ten eyes, forniceal conjunctiva in three eyes, and tarsal conjunctiva in one eye. The extensive @entity5 affected a median of 10 clock hours of limbal conjunctiva and 10 clock hours of @entity267 , with corneal epithelial invasion for a median of 50% (range 20%-100%) of its surface. @entity1138 0.04% four times daily was applied for a median of three cycles (range 1-4 cycles). Complete @entity5 regression was documented in all ten cases (100%). There was no recurrence over a mean follow up of 22 months (range 6-50 months). @entity1138 caused moderate temporary local irritation and conjunctival erythema and chemosis, but no long-term intraocular or extraocular complications. CONCLUSIONS: Based on this small series, topical @entity1138 0.04% appears to be a safe and effective therapy for conjunctival or corneal @entity6461 , even when there is extensive @entity5 .

title: Topical XXXX for extensive, recurrent @entity957 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'conjunctival tumor', 'recurrent tumor', 'conjunctival malignancy']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C', 'Mitomycin C']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['corneal squamous cell carcinoma']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']


abstract: BACKGROUND: Anterior cervical corpectomy provides the most direct and thorough surgical approach for anterior decompression when @entity1745 is found directly behind the vertebral body. However, anterior cervical fusion has been shown to be associated with the development of new degenerative changes at levels immediately adjacent to the fused segments. Th e incidence of @entity1347 ( @entity1347 ) following anterior cervical corpectomy has not been widely reported. We set out to determine the incidence of clinical @entity1347 following anterior cervical corpectomy. METHODS: We retrospectively reviewed all available medical charts and radiographic studies of all cases of anterior cervical corpectomy performed at the Barrow Neurological Institute over a 4-year period with a minimum 24-month follow-up. Factors assessed included the success of arthrodesis, the presence of degenerative changes on serial follow-up radiographs, and the development of new @entity16 . RESULTS: Seventy-six @entity1 met the criteria for inclusion: 54 had undergone a 1-level corpectomy, 18 underwent a 2-level corpectomy, and 4 underwent a 3- or 4-level corpectomy. Arthrodesis was performed with either allograft or autograft and anterior cervical plating. All @entity1 achieved successful fusion. Follow-up was available for a minimum of 2 years in all cases, with a mean length of 3.6 years. Sixteen @entity1 (21%) eventually developed radiological and clinical evidence of degenerative changes at adjacent levels. In 10 of 11 @entity1 who developed clinical symptoms within 2 years, the changes represented progression of pre-existing, asymptomatic @entity179 . Five @entity1 developed degenerative changes more than 5 years after surgery; these were all associated with an unrelated new insult to the cervical spine such as @entity130 . CONCLUSIONS: Anterior cervical corpectomy with fixation can accelerate degenerative changes identified preoperatively at adjacent, asymptomatic levels of the cervical spine. LEVEL OF EVIDENCE: Retrospective cohort study (level 2b).

title: Anterior cervical corpectomy and fusion accelerates XXXX at adjacent vertebral segments.

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['adjacent segment disease', 'ASD']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative disease']

answer: @entity179 :: (MESH:D019636,Disease) :: ['degenerative disease']


abstract: INTRODUCTION: Anesthetic management remains an understudied aspect of free autologous breast reconstruction. This study aims to critically examine intraoperative anesthetic management as it relates to free flap perfusion and its effect on major complications. METHODS: A retrospective cohort study was performed examining all abdominally based free autologous breast reconstructions from 2005 to 2011 at a single institution. Analysis focused on perioperative care and specifically fluid administration, urine output (UOP), vasopressor administration, and case duration. Outcomes included major @entity260 . A post-hoc analysis was performed to determine anesthetic factors associated with @entity715 events. RESULTS: Overall, 682 @entity1 (1033 flaps) were included. @entity1 with low UOP had lower rates of intraoperative fluid infusion rates/kg (p  =  0.0001), Estimated @entity190 (EBL) (p  =  0.006) and pressor administration (p  =  0.03), but no significant differences were noted in intraoperative @entity715 events according to UOP. However, the below normal UOP cohort demonstrated a significant increased rate of delayed postoperative @entity715 (p  =  0.03). A post hoc analysis of postoperative @entity715 events revealed that low rates of fluid resuscitation (OR  =  3.01, p  =  0.04) and low intraoperative UOP (OR  =  3.67, p  =  0.04) were independently associated with delayed @entity715 . A sub-analysis demonstrated that @entity1 with >= 2 comorbidities and below normal UOP were at particular risk (any delayed @entity715 event OR  =  4.3, p  =  0.03; any delayed @entity49 OR  =  9.1, p  =  0.03). CONCLUSIONS: This study demonstrates that intraoperative fluid under-resuscitation may place @entity1 at increased risk for postoperative flap @entity715 , and low UOP is an important metric whereby intraoperative resuscitation should be gauged. @entity1 with comorbid conditions and below normal intraoperative UOP should be monitored particularly closely for delayed @entity715 events. Level of evidence: Prognostic/risk category, level II.

title: Intraoperative perfusion management impacts postoperative outcomes: An analysis of 682 autologous breast reconstruction XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['Blood Loss']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['intraoperative and postoperative complications']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombosis', 'thrombotic']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract:
BACKGROUND: Reduced intensity conditioning before allogeneic stem cell transplantation is an option for @entity1 not eligible for myeloablative standard procedure. In recent years alemtuzumab, an anti @entity7638 antibody has gained much interest in this setting for its particular immunosuppresive properties.
 MATERIAL/METHODS: We evaluated clinical results of allogeneic stem cell transplantation in nine @entity1 (2 females and 7 males, median age 51, range 26-65) after reduced intensity conditioning consisting of @entity1863 , @entity8778 and alemtuzumab. The donors were HLA identical siblings (7) or unrelated (2). Peripheral blood stem cells mobilized with @entity1261 were used. @entity205 alone was used for GvHD prevention after transplantation. RESULTS: 4 @entity1 (44%) are alive at 24-42 months after transplantation and 3 @entity1 (33%) remain in complete remission at 26-42 months, including one after donor lymphocyte infusion for decreasing hematopoietic chimerism. No @entity2132 was observed and only 3 @entity1 (33%) developed @entity2132 . High rate (56%) of @entity2834 reactivation and 2 cases of @entity378 were noted. All deceased patents died due to disease relapse and progression.
 CONCLUSIONS: Reduced intensity conditioning with alemtuzumab and allogeneic stem cell transplantation offers potential cure to @entity1 not eligible for conventional procedure. Better methodology of chimerism evaluation is mandatory to improve results of transplantations by implementation donor lymphocyte infusions.

title: Clinical evaluation of @entity1863 , XXXX and alemtuzumab as reduced intensity conditioning for stem cell transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8778 :: ('MESH:D017338', 'Chemical') :: ['cladribine']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporine']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['chronic graft versus host disease', 'acute graft versus host disease']

entities_list: @entity1863 :: ('MESH:D002066', 'Chemical') :: ['busulfan']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

answer: @entity8778 :: (MESH:D017338,Chemical) :: ['cladribine']


abstract: @entity14855 is implicated in a myriad of @entity1 diseases as well as homeostasis and virulence in several major @entity1 pathogenic microorganisms. The fungus @entity54 is a leading cause of @entity204 in the rapidly expanding immunocompromised @entity1 population. Current antifungal treatments for @entity3 are often ineffective, and novel therapeutic approaches are urgently needed. We demonstrate that a mutant of A. fumigatus lacking the @entity14855 A (cnaA) catalytic subunit exhibited defective hyphal morphology related to apical extension and polarized growth, which resulted in drastically decreased filamentation. The delta cnaA mutant lacked the extensive lattice of invading hyphae seen with the wild-type and complemented strains. Sporulation was also affected in the delta cnaA mutant, including morphological @entity154 with the absence of surface rodlets and the added presence of disjunctors creating long conidial chains. Infection with the delta cnaA mutant in several distinct animal models with different types of immunosuppression and inoculum delivery led to a profound attenuation of pathogenicity compared to infection with the wild-type and complemented strains. Lung tissue from animals infected with the delta cnaA mutant showed a complete absence of hyphae, in contrast to tissue from animals infected with the wild-type and complemented strains. Quantitative fungal burden and @entity8995 scoring confirmed these findings. Our results support the clinical observation that substantially decreasing fungal growth can prevent disease establishment and decrease mortality. Our findings reveal that @entity14855 appears to play a globally conserved role in the virulence of several pathogenic fungi and yet plays specialized roles in each and can be an excellent target for therapeutic intervention.

title: @entity14855 controls growth, morphology, and pathogenicity in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity14855 :: ('CHEBI:53439', 'Chemical') :: ['calcineurin', 'Calcineurin']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['conidial defects']

entities_list: @entity8995 :: ('MESH:D054060', 'Disease') :: ['pulmonary infarct']

entities_list: @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['infectious death']

answer: @entity54 :: (746128,Species) :: ['Aspergillus fumigatus']


abstract: BACKGROUND: Rotational @entity432 refers to @entity9085 as a result of mechanical occlusion or @entity850 of the vertebral artery by @entity717 . In most cases, symptoms are produced on extension or rotation to one side. No case of @entity5684 with bilateral presentation at the C4 level has yet been reported. CASE DESCRIPTION: A 54-year-old @entity1 presented with symptomatic bilateral @entity5684 induced by @entity717 . The @entity1 complained of intermittent dizziness, episodes of @entity892 , nonpulsatile tinnitus, and @entity10 indicative of @entity9085 with exacerbation of symptoms on rotation of his head to either side. Computed tomography angiography showed bilateral @entity9085 , and dynamic cerebral angiography revealed @entity432 , with compression of the ipsilateral vertebral artery on @entity717 to either side. Bilateral surgical decompression at C4-5 with anterior cervical diskectomy and fusion with a plate was performed. CONCLUSIONS: Bony obstruction of the vertebral artery on @entity717 tends to occur at levels C4 and below, affecting the ipsilateral side. In this rare case, symptomatic bilateral @entity9085 occurred as a result of bony compression and was symptomatic on @entity717 both to the right and to the left. This @entity850 was improved with anterior decompression bilaterally, and no further events occurred postoperatively.

title: Rare case of bilateral XXXX caused by C4-5 spondylotic changes manifesting with bilateral @entity5684 .

entities_list: @entity9085 :: ('MESH:D014715', 'Disease') :: ['vertebrobasilar insufficiency', 'vertebral artery insufficiency', 'vertebral artery stenosis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['double vision']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['vertebral artery occlusion syndrome', 'bilateral rotational vertebral artery occlusion']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['head rotation']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity5684 :: ('MESH:D016532', 'Disease') :: ["bow hunter's syndrome"]

answer: @entity9085 :: (MESH:D014715,Disease) :: ['vertebral artery stenosis']


abstract: To determine the potential clinical utility of peripheral opioid action using a clinical model of @entity5 treatment-induced @entity32 and @entity158 that allowed for topical application of @entity1286 in the damaged tissue (oral mucosa). This pilot study followed a two blocks design. Ten @entity1 with @entity158 were enrolled in the first block (dose-response relationship finding) and randomized in two groups to receive oral rinses with 15 ml of either 1 per thousand or 2 per thousand @entity1286 solution. Twenty-two @entity1 were enrolled into the second block (efficacy and safety determination). Additionally, serum concentrations of @entity1286 were measured in five representative @entity1 . In the first block (n=10) a dose-response relationship for topical @entity1286 was found. Rinses with 2 per thousand - @entity1286 solution showed better @entity158 relief (median 80%, range 70-80%) than those with 1 per thousand (median 60%, range 55-70%; P=0.0238). Therefore, subsequent @entity1 enrolled for the second block (n=22) received oral rinses with 2 per thousand - @entity1286 solution. In these @entity1 the time to good (>or=50%) or to complete (100%) @entity158 relief was 28 (+/-12)min after the first mouthwash, and the duration of relief was on average 216 (+/-25)min. Twenty @entity1 (90%) received the successive mouthwashes every 3 h and 10% of them every 2 h. The duration of severe @entity158 at the moment of swallowing was 5.17 (+/-1.47) days. Only six @entity1 needed @entity1337 , and the time elapsed before the first supplemental analgesic was 1.18 (+/-0.8) days. The duration of severe functional impairment was 1.52 (+/-1.31) days, thus allowing us to feed the @entity1 by mouth with liquid-food supplementation. During our experiment no systemically active detectable concentrations of @entity1286 were found (GC-MS analysis). The most important side effect attributable to @entity1286 mouthwashes was burning/itching sensation (very mild to mild intensity). @entity1 with @entity158 chemoradiotherapy-induced @entity3136 could be alleviated using topical @entity1286 mouthwashes.

title: Potential utility of the peripheral analgesic properties of XXXX in @entity3136 -related @entity158 : a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['supplementary analgesia']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful', 'painful oral mucositis']

answer: @entity1286 :: (MESH:D009020,Chemical) :: ['morphine']


abstract: UNASSIGNED: Background and purpose - Dislocation is one of the most common complications following hip arthroplasty. Delay until reduction leads to @entity158 for the @entity1 , and may increase the risk of complications. We investigated the safety aspect of a fast-track pathway for dislocated hip arthroplasties and evaluated its effect on surgical delay and length of stay (LOS). @entity1 and methods - 402 consecutive and unselected @entity3029 (253 @entity1 ) were admitted at our institution between May 10, 2010 and September 31, 2013. The fast-track pathway for early reduction was introduced on January 9, 2011. Fast-track @entity1 with a suspected dislocation (with no radiographic verification) were moved directly to the post-anesthesia care unit and then straight to the operating room. Dislocation was confirmed under fluoroscopy with reduction under general anesthesia. Surgical delay (in hours), LOS (in hours), perioperative complications, and complications during the hospital stay were recorded. Dislocation status for fast-track @entity1 (confirmed or unconfirmed by fluoroscopy) was also recorded. Results - Both surgical delay (2.5 h vs. 4.1 h; p < 0.001) and LOS (26 h vs. 31 h; p < 0.05) were less in @entity1 admitted through the fast-track pathway than in @entity1 on regular pathway. Perioperative complications (1.6% vs. 3.7%) and complications during the hospital stay (11% vs. 15%) were also less, but not statistically significantly so. Only 1 @entity1 admitted through fast-track pathway had a @entity174 instead of a dislocation; all the other fast-track @entity1 with suspected dislocation actually had @entity3029 . Interpretation - The fast-track pathway for reduction of @entity572 results in less surgical delay and in reduced LOS, without increasing perioperative complications or complications during the @entity1 's stay.

title: Fast-track pathway for reduction of XXXX reduces surgical delay and length of stay.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['dislocated hip arthroplasty']

entities_list: @entity3029 :: ('MESH:D004204', 'Disease') :: ['dislocations']

answer: @entity572 :: (MESH:D006617,Disease) :: ['dislocated hip arthroplasty']


abstract: Reversal of hemodynamic alterations induced by @entity1363 (1.0 mg/kg of body weight), @entity4763 (0.44 mg/kg), and @entity12691 (0.1 mg/kg) with @entity3160 (0.1 mg/kg) and @entity5757 (0.25 mg/kg) was evaluated in 5 @entity235 . The @entity235 were anesthetized with @entity5161 for instrumentation. With return to consciousness, baseline values were recorded, and the @entity1363 / @entity4763 / @entity12691 mixture with @entity10445 was administered IV. Hemodynamic data were recorded for 60 minutes, and then a reversal mixture of @entity3160 and @entity5757 was administered IV. All variables were measured 1 minute from beginning of the reversal injection. Mean arterial pressure, pulmonary arterial pressure, systemic vascular resistance, and right @entity64 work index increased significantly (P < 0.05) above baseline at 60 minutes. Cardiac index and central venous pressure significantly decreased below baseline at 60 minutes. After reversal, mean arterial pressure and central venous pressure significantly decreased from baseline, whereas cardiac index, pulmonary arterial pressure, and right @entity64 work index increased significantly above baseline. Heart rate, cardiac index, and right @entity64 work index increased significantly above the 60-minute value after reversal. Mean arterial pressure and systemic vascular resistance decreased significantly (P < 0.05) below the 60-minute value after reversal. The hemodynamic alterations accompanying @entity1363 / @entity4763 / @entity12691 sedation-anesthesia may be rapidly reversed with a combination of @entity3160 and @entity5757 .

title: XXXX / @entity5757 antagonism of hemodynamic alterations induced by a combination of @entity1363 , @entity4763 , and @entity12691 in @entity235 .

entities_list: @entity3160 :: ('MESH:D015016', 'Chemical') :: ['yohimbine']

entities_list: @entity12691 :: ('MESH:D002077', 'Chemical') :: ['butorphanol', 'butorphanol tartrate']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['ventricular stroke']

entities_list: @entity4763 :: ('MESH:D014991', 'Chemical') :: ['xylazine', 'xylazine hydrochloride']

entities_list: @entity10445 :: ('MESH:D006024', 'Chemical') :: ['glycopyrrolate']

entities_list: @entity5757 :: ('MESH:D005442', 'Chemical') :: ['flumazenil']

entities_list: @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam maleate', 'midazolam']

answer: @entity3160 :: (MESH:D015016,Chemical) :: ['Yohimbine']


abstract: OBJECTIVES: Correlates of serial @entity2333 changes were scarcely evaluated. We aimed to evaluate them in @entity1 with resistant @entity101 , with particular attention to the importance of changes in @entity551 (BP). METHODS: In a prospective study, two carotid-femoral pulse wave velocity (cf- @entity122 ) measurements (three measures in each occasion) were performed with the Complior equipment in 442 resistant @entity101 @entity1 over a mean follow-up of 4.6 years. Multivariable regressions assessed the independent correlates of changes in cf- @entity122 . All analyses were further adjusted for baseline cf- @entity122 and BP values, and for the time interval between measurements. RESULTS: Carotid-femoral @entity122 had a median increase of 0.11m/s per year (1.1% per year). Overall, 224 @entity1 (51%) had an increase or persisted with high cf- @entity122 , whereas 218 (49%) reduced or persisted with low values. On multivariable regressions, both changes in clinic SBP (partial correlation 0.34, P<0.001) and in 24-h SBP (partial correlation 0.40, P<0.001) were correlates of changes in cf- @entity122 . This means that the white-coat effect, defined as the difference between clinic and daytime BPs, affected cf- @entity122 changes (partial correlation 0.19, P<0.001). The other independent correlates of @entity2333 were older age, presence of @entity6 , higher waist circumference and worse renal function. CONCLUSION: The exaggerated white-coat effect, by acutely increasing clinic BPs during cf- @entity122 examination, may partially obscure the beneficial effects of reducing ambulatory BP levels on @entity536 . @entity432 under ambulatory conditions may be needed to correctly assess @entity2333 changes in resistant @entity101 @entity1 .

title: Correlates of @entity2333 in @entity1 with resistant XXXX : importance of clinic and ambulatory blood pressure changes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity536 :: ('MESH:C538265', 'Disease') :: ['aortic stiffness attenuation']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['Arterial stiffness measurements']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness', 'aortic stiffness progression']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['clinic and ambulatory blood pressures']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Sixty-one @entity1 with @entity43 were treated with intensive high-dose, short-course chemotherapy that consisted of @entity900 (120 mg/m2) and @entity632 (70 mg/m2) every 3 weeks for four cycles. @entity1 in complete clinical remission were offered @entity1605 ( @entity1605 ). @entity1 with minimal or no residual disease at @entity1605 were randomized to either @entity786 (1000 mg/m2 every 21 days for six cycles) or whole-abdominal radiation therapy. All @entity1 completed therapy with a median leukocyte nadir 1.3/microliter and platelet nadir of 90/microliters. Forty-five @entity1 (74%) had a complete clinical response. Results of twenty-two of 36 second-look procedures (64%) showed no evidence of disease (NED). After @entity1605 , 19 @entity1 received six courses of @entity786 and 16 @entity1 received whole-abdominal radiation. Nine @entity1 who refused @entity1605 and one @entity1 with negative @entity1605 findings refused additional treatment. The median survival time for all @entity1 was 51.3 months. High-dose intensive chemotherapy regimens have high response rates, but survival needs to be compared with traditional low-dose regimens. Although high-dose @entity900 and @entity632 were myelosuppressive, the resulting complications were manageable. There was no significant difference between the mean survival times of @entity1 receiving Cytoxan, abdominal radiation, or no treatment as second-line therapy.

title: High-dose, short-duration @entity900 / @entity632 combination chemotherapy for advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['epithelial ovarian cancer']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['SLL', 'second-look laparotomy']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian epithelial cancer']


abstract: This study aimed to evaluate the effects of dietary @entity1735 /lipid ( @entity435 :L) ratios on stress, liver oxidative status and non-specific immune responses of fingerling @entity54239 . Fish were fed six isonitrogenous and isoenergetic diets containing various @entity435 :L ratios for 10 weeks. After the feeding trial, fish were challenged by @entity1678 and survival rate was recorded for the next 10 days. The lowest plasma @entity701 , @entity880 , @entity492 aminotransferase and @entity493 aminotransferase were all observed in fish fed a @entity435 :L ratio of 5.64. They were significantly (P < 0.05) lower than those of fish offered the lowest @entity435 :L ratio, but showed little difference (P > 0.05) with those of fish fed the highest @entity435 :L ratio. This also held true for liver catalase and @entity2041 peroxidase activities, whereas the opposite was true for liver reduced @entity2041 contents, plasma lysozyme and alternative complement (ACH50) activities. Contrary to leucocyte counts, plasma @entity413 levels, liver @entity1234 contents, blood haemoglobin contents and erythrocyte numbers all increased significantly (P < 0.05) with decreasing dietary @entity435 :L ratios. The highest plasma total protein and globulin content both observed in fish fed a @entity435 :L ratio of 2.45 was significantly (P < 0.01) higher than that of fish offered the lowest @entity435 :L ratio, but showed no statistical difference (P > 0.05) with that of the other groups. After challenge, fish fed the lowest @entity435 :L ratio obtained significantly (P < 0.05) low survival rate. However, survival rate showed little difference (P > 0.05) as dietary @entity435 :L ratios ranged from 3.67 to 24.20. The results of this study indicated that high dietary lipid may cause metabolic stress of fingerling @entity54239 , as might consequently lead to the elevated liver oxidation rates, @entity409 , @entity308 immunity and reduced resistance to A. hydrophila infection of this species, whereas the opposite was true for @entity1735 enriched diets.

title: Dietary XXXX /lipid ratios affect stress, oxidative status and non-specific immune responses of fingerling @entity54239 , @entity54239 .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed']

entities_list: @entity54239 :: ('75352', 'Species') :: ['blunt snout bream']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['impaired liver function']

entities_list: @entity1678 :: ('644', 'Species') :: ['Aeromonas hydrophila']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']