abstract: OBJECTIVES: This study sought to compare @entity1188 ( @entity1188 ) measured by magnetic resonance imaging in @entity1 with successful (myocardial blush grade [ @entity7584 ] 2/3) versus unsuccessful ( @entity7584 0/1) microcirculatory reperfusion in the INFUSE-AMI (Intracoronary Abciximab and Aspiration Thrombectomy in @entity1 With Large @entity583 ) trial. BACKGROUND: Successful microcirculatory reperfusion, defined angiographically by @entity7584 2 or 3, is associated with improved outcomes in @entity1 with ST-segment elevation @entity583 . The precise mechanism underlying this association is not well defined. METHODS: The INFUSE-AMI trial randomized 452 @entity1 with anterior ST-segment elevation @entity583 to intracoronary bolus abciximab delivered locally at the @entity4798 versus no abciximab, and to manual thrombus aspiration versus no aspiration. The primary endpoint was @entity1188 (percentage of left ventricular mass) at 30 days. RESULTS: @entity7584 2/3 was achieved in 367 @entity1 (81.4%). @entity1188 was significantly lower in @entity1 with @entity7584 2/3 than in those with @entity7584 0/1 (median: 16.7% [interquartile range (IQR): 7.0 to 22.7] vs. 19.5% [IQR: 11.1 to 29.2]; p = 0.002). Intracoronary abciximab further reduced @entity1188 in @entity1 with @entity7584 2/3 (median: 14.4% [IQR: 5.4 to 20.9] vs. 17.4% [IQR: 10.5 to 23.8]; p = 0.01). @entity7584 2/3 was associated with    30% reduction in @entity1188 mass (p = 0.002) and    90% reduction in @entity3885 on day 5. Ejection fraction was higher with @entity7584 2/3 at 30 days: median: 50.3% (IQR: 43.8 to 57.8) versus 46.9% (IQR: 37.5 to 54.0); p = 0.004. At 30 days, the rate of death was significantly lower (1.7% vs. 8.3%; p = 0.0008) in the @entity7584 2/3 group. CONCLUSIONS: @entity7584 2/3 occurs in 80% of ST-segment elevation @entity583 @entity1 treated with primary percutaneous coronary intervention and is associated with smaller @entity1188 , less @entity3885 , improved ejection fraction, and significantly lower 30-day mortality. (Intracoronary Abciximab and Aspiration Thrombectomy in @entity1 With Large @entity583 [INFUSE-AMI]; NCT00976521).

title: Relationship between myocardial reperfusion, @entity1188 , and mortality: the INFUSE-AMI (Intracoronary Abciximab and Aspiration Thrombectomy in @entity1 With Large XXXX ) trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4798 :: ('MESH:D020520', 'Disease') :: ['infarct lesion']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['microvascular obstruction']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['IS', 'infarct', 'infarct size']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'Anterior Myocardial Infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['Anterior Myocardial Infarction']


abstract: BACKGROUND: Asthmatic @entity1 have a TH2-predominant milieu that is associated with humoral immunity. However, little is known about whether humoral immune responses to viral antigens differ between @entity748 and nonasthmatic @entity1 . OBJECTIVE: To determine whether humoral immune response differs in @entity748 @entity1 vs nonasthmatic @entity1 . METHODS: Measles virus specific IgG antibody levels were determined for the Rochester Family Measles Study cohort (n = 876), a convenience sample of healthy @entity1 5 to 12 years of age in Rochester, MN. We conducted comprehensive medical record reviews of 838 @entity1 who were eligible for this study. We determined the @entity1 's @entity565 status at the time of determination of antibody levels by applying predetermined criteria for @entity565 . Comparisons were made using the 2-sample t test or chi2 test. RESULTS: Of the 838 @entity1 , 156 (18.6%) had @entity565 at the time of the determination of antibody levels and were not taking systemic @entity230 within 14 days of specimen collection. Among those with a nonequivocal antibody reading, the seropositive response rates were similar in @entity748 @entity1 and nonasthmatic @entity1 (89.7% vs 90.3%, respectively; P = .83). However, the equivocal response rates were slightly higher among @entity748 @entity1 than nonasthmatic @entity1 (6.4% vs 4.7%, respectively). CONCLUSION: Asthmatic @entity1 seem to have similar humoral immune responses to measles vaccine as those without @entity565 . Although the findings reassure health care practitioners, whether this finding is generalizable to other vaccines and whether @entity748 @entity1 with low antibody levels have normal cell-mediated immunity need to be elucidated in future studies.

title: XXXX and measles vaccine response.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

answer: @entity565 :: (MESH:D001249,Disease) :: ['Childhood asthma']


abstract: Ten @entity1 28-54 years old with recurrent attacks of @entity5968 ( @entity662 associated with transient ST-segment elevation) culminating in acute @entity583 were studied. Systemic blood pressure and heart rate remained unchanged or decreased during @entity662 . Diagnosis of @entity583 was made on the basis of pathognomonic enzyme changes and T-wave inversions persisting for several weeks (seven @entity1 ) or development of Q waves (three @entity1 ). Complications were similar to the ones previously observed in conventional @entity583 . None of these @entity1 died. Past history was characterized by absence of effort angina. Exercise stress testing after @entity1188 was normal, and coronary arteriography revealed a spectrum of pathology, ranging from normal arteriograms to @entity66 . Intraaortic balloon pumping was ineffective in two @entity1 , but subsequent coronary bypass surgery shortly after @entity583 was not followed by further attacks of @entity662 . Follow-up of these @entity1 revealed a benign course. Alcohol drinking and cigarette smoking appeared to be very prevalent in this group.

title: The syndrome of @entity5968 culminating in acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity5968 :: ('MESH:D000788', 'Disease') :: ['variant angina']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['three-vessel disease']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: BACKGROUND: @entity2023 and @entity1244 are frequently associated with @entity565 . The purpose of this study was to determine the impact of self-reported @entity2023 and @entity1244 on lower @entity1030 in a large cohort of @entity1 with well-characterized @entity565 . METHODS: A cohort study of @entity1 in two trials of the American Lung Association-Asthma Clinical Research Centers: 2,031 asthmatics in the Safety of Inactivated Influenza Vaccine in Asthma in Adults and @entity1 (SIIVA) trial and 488 asthmatics in the Effectiveness of Low Dose @entity2544 as Add-on Treatment in Asthma (LODO) trial. At baseline, @entity1 reported the presence of @entity2023 and @entity1244 , and then lung function and @entity565 control were measured. During the trials, @entity1 were monitored for @entity565 exacerbations. RESULTS: More than 70% of @entity1 reported either @entity2023 or @entity1244 . @entity1244 was more common in female @entity1 (odds ratio, 1.46 [SIIVA]), those with @entity354 (odds ratio, 2.21 [SIIVA]), and those of white race (odds ratio, 1.53 [SIIVA]). Similar associations were seen for @entity2023 . LODO @entity1 with @entity2023 and @entity1244 had @entity304 and a trend toward more @entity25 . @entity1 with @entity2023 had higher baseline lung function than those without @entity2023 measured by peak flow (91.2% vs 95.8% in the SIIVA trial). @entity1 with @entity1244 had similar lung function to those without @entity1244 . @entity1 with and without @entity2023 had similar exacerbation rates. In the LODO trial only, @entity1 with @entity1244 had @entity2789 (5.68 per @entity1 per year vs 3.72 per @entity1 per year). CONCLUSION: @entity2023 and @entity1244 are associated with more severe asthmatic symptoms and, in @entity1 with poorly controlled @entity565 , more exacerbations but are not associated with low lung function.

title: @entity2023 and @entity1244 in XXXX : differential effects on symptoms and pulmonary function.

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis', 'Sinusitis']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Children', 'patient', 'Participants']

entities_list: @entity2544 :: ('MESH:D013806', 'Chemical') :: ['Theophylline']

entities_list: @entity2789 :: ('MESH:D018450', 'Disease') :: ['increased asthma exacerbations']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'allergic rhinitis']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['increased asthma symptoms']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['airway disease']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: OBJECTIVE: To evaluate different strategies for extended resections of @entity201 on radicality and survival. SUMMARY BACKGROUND DATA: Surgical resection of @entity201 is the only potentially curative treatment. Resection of central bile duct @entity189 , however, cannot always comply with the general principles of surgical oncology to achieve wide @entity5 -free margins with no-touch techniques. METHODS: From 1988 to 1998, 95 @entity1 underwent resection of @entity201 . Eighty @entity1 had hilar and hepatic resections and 15 had liver transplantation and partial pancreatoduodenectomy (LTPP; i.e., eradication of the entire biliary tract using a no-touch technique). RESULTS: The 60-day death rate was 8%. The overall 1- and 5-year survival rates were 67% and 22%, respectively. Five-year survival rates after R0, R1, and R2 resections were 37%, 9%, and 0%. In a multivariate analysis, surgical radicality was the strongest determinant of survival (p < 0.001). The rate of formally curative resection (R0 resection) was significantly lower in hilar resections (29%) than in liver resections (left hemihepatectomy 59%, right hemihepatectomy 55%, right trisegmentectomy 65%; p < 0.05). The highest rate of R0 resection was observed after LTPP (93%; p < 0.05). Right trisegmentectomies achieved the highest rate of 5-year survival after R0 resection (57%). In a multivariate analysis of @entity1 survival after R0 resection, additional portal vein resection was the only significant factor. The 5-year survival rate after formally curative liver resection with portal vein resection was 65% versus 28% without. CONCLUSION: Extended resections, especially right trisegmentectomies and LTPP, resulted in the highest rate of R0 resection. Right trisegmentectomy together with portal vein resection best represents the principles of surgical oncology and may be regarded as the surgical procedure of choice. Immunosuppression limits the applicability of LTPP.

title: Extended resections for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['hilar cholangiocarcinoma', 'hilar cholangiocarcinomas']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

answer: @entity201 :: (MESH:D018281,Disease) :: ['hilar cholangiocarcinoma']


abstract: Predominant symptoms in @entity263 @entity1 are @entity323 and urinary problems. As decreases of these functions can be attributed to disease and treatment but also to age-related decreases, we conducted a study on a German reference population measuring general quality of life (QoL) as well as prostate-specific symptoms. In cooperation with a German health insurance company, 3000 questionnaires were mailed to a randomly selected sample of @entity1 aged 45-75 years. Questionnaires used were the EORTC QLQ-C30 and a prostate-specific module (PSM). One thousand one hundred and fifty questionnaires were returned (response rate: 37.6%). QoL data from this reference population were compared to QoL data from a historical cohort study of @entity263 @entity1 following either prostatectomy or radiotherapy. In terms of general QoL, the reference population showed similar QoL scores as prostatectomy @entity1 , but better scores than radiotherapy @entity1 . On the PSM, the reference sample showed better overall QoL, but a surprisingly high extent of @entity323 , urinary problems and @entity6475 . Taking into account the sensitive topic of this study ( @entity458 ), the response rate is more than satisfying. Older @entity1 in our randomly selected, population-based sample do not show perfect erectile and urinary function. These findings should be considered when interpreting QoL data of @entity263 @entity1 .

title: Prostate-specific symptoms of XXXX in a German general population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'erectile dysfunctions']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexuality and urinary problems']

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['psychic strain']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: INTRODUCTION: @entity39489 , originally described in Japanese @entity1 , is a rare form of stationary @entity15535 in @entity1 with normal acuity. OBSERVATION: We report the case of an 8-year-old @entity1 who presented with an abnormal terrified behavior in the dark. Thorough questioning revealed @entity227 . Her clinical examination (visual acuity, Goldmann @entity227 ) were normal. The fundus examination showed golden-brown color, grayish, almost greenish yellow discoloration in the peripheral area with no osteoclast. This abnormality disappeared after prolonged dark adaptation. The electroretinogram showed a reduced b wave amplitude under scotopic conditions. Her parents were cousins. CONCLUSION: This diagnosis should be suggested when @entity227 is associated with typical fundus aspect resolving after dark adaptation (so called Mizuo-Nakamura phenomenon). The long-term prognosis in these @entity1 is good in the absence of clinical progression. This is a genetic @entity74 caused by mutations in the gene coding for arrestin located in 2q37.1.

title: [ XXXX or stationary congenital night blindness: a case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients', 'people']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field, and color vision', 'hemeralopia']

entities_list: @entity15535 :: ('MESH:D009755', 'Disease') :: ['night blindness']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal recessive disease']

entities_list: @entity39489 :: ('MESH:C537743', 'Disease') :: ['Oguchi disease']

answer: @entity39489 :: (MESH:C537743,Disease) :: ['Oguchi disease']


abstract: PURPOSE: To investigate the common indications for polysomnogram (PSG) associated co-morbid conditions, evaluation strategies, treatment options, and outcomes in a series of @entity1 diagnosed with @entity27 ( @entity27 ) by a PSG. METHODS: Retrospective chart review of @entity1 who underwent PSG over a 7-year period was done. @entity1 with PSG diagnosed @entity27 were included in this study. RESULTS: A total of 97 @entity1 (59 males, mean age 4.6 months, standard deviation 3.3 months) were diagnosed with @entity27 (AHI   >=    1/hr) based on PSG. The most common indication for PSG in @entity1 were excessive snoring (53%) followed by nocturnal desaturations (24%). Associated co-morbid conditions included @entity354 (30%), @entity12203 (24%), and @entity2122 (16%). @entity74 were found in 53%, of which trisomy 21 was the most common. Surgical treatments were employed in 36% and @entity26 therapy in 15%. Thirty-eight @entity1 were followed up with a repeat sleep study after a median interval of 8 months (range 1-24 months), of whom 26/38 had resolution of symptoms. Twenty-seven @entity1 (28%) were followed clinically after a mean interval of 5 months of intervention (range, 1-34.5 months), in whom the symptoms resolved in 23/27 @entity1 . Seven @entity1 were deceased at review. Causes of @entity204 included @entity159 , @entity1576 , @entity177 , or unknown causes. CONCLUSION: The etiologies of @entity27 in @entity1 are different when compared to older @entity1 . PSG is feasible and a valuable tool in the diagnosis of @entity27 in @entity1 and may help determine timely and appropriate evaluation and interventions. Clinical improvement in symptoms and resolution of PSG parameters were noted following medical and/or surgical interventions. Prospective studies need to be done to ascertain the long-term outcome of @entity1 diagnosed with @entity27 to assess the benefits of early intervention on their neurocognitive development.

title: XXXX in infancy: a 7-year experience at a pediatric sleep center.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants', 'Infants']

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['craniofacial abnormalities']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['hepatic failure, kidney failure']

entities_list: @entity12203 :: ('MESH:D055092', 'Disease') :: ['laryngomalacia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Genetic abnormalities']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastro-esophageal reflux']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']

answer: @entity27 :: (MESH:D020181,Disease) :: ['Obstructive sleep apnea']


abstract: UNASSIGNED: To investigate the performance of a biexponential signal decay model using DWI in @entity121 and to differentiate @entity6558 ( @entity6558 )/ @entity6017 ( @entity6017 ), @entity6182 ( @entity6182 ) and @entity3986 ( @entity3986 ) utilizing diffusion-weighted imaging. 11 healthy volunteers (control group) and 46 @entity1 with @entity121 were enrolled in the retrospective study. 27 of 46 @entity1 had @entity6558 / @entity6017 , 7 @entity1 @entity6182 and 12 @entity1 @entity3986 . After conventional MR sequences, diffusion weighted imaging with a b-factor ranging from 0 to 1200  s/mm(2) was performed on both thighs. The intra-muscular signal-to-noise ratios (SNRs) on multiple-b DWI images were measured for 7 different muscles and compared among the different groups. The median T2 signal intensity and biexponential apparent diffusion coefficients (ADC), including standard ADC, fast ADC, and slow ADC values, were compared among the different groups. The intra-muscular SNRs were statistically significantly different depending on the b value, and also found among the 4 groups (p  <  0.05). The median T2 signal intensity of the normal muscles in control group was statistically significantly lower than that of @entity121 in the @entity6558 / @entity6017 , @entity6182 and @entity3986 groups (p  =  0.000), while there were no statistically significant differences among the @entity6558 / @entity6017 , @entity6182 , and @entity3986 groups (p  >  0.05). The median standard ADC value of the @entity121 in @entity6182 was statistically significantly lower than that of normal muscles in the control group (p  =  0.000) and the median ADC value of the @entity121 in @entity6558 / @entity6017 @entity1 was statistically significantly greater than that of the @entity6182 (p  =  0.000) and @entity3986 groups (p  =  0.005). The median slow ADC value of the @entity121 in @entity3986 @entity1 and @entity6558 / @entity6017 @entity1 was statistically significantly greater than that of @entity6182 @entity1 (p  <  0.05). Intra-muscular SNR decay curves and biexponential ADC parameters are useful in distinguishing among @entity6558 / @entity6017 , @entity6182 , and @entity3986 .

title: The diagnostic value of biexponential apparent diffusion coefficients in XXXX .

entities_list: @entity6182 :: ('MESH:D006008', 'Disease') :: ['Glycogen Storage Diseases', 'GSDs']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6017 :: ('MESH:D003882', 'Disease') :: ['Dermatomyositis', 'DM']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['MDs', 'Muscular Dystrophies']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['edematous muscles', 'myopathy', 'myopathies']

entities_list: @entity6558 :: ('MESH:D017285', 'Disease') :: ['Polymyositis', 'PM']

answer: @entity121 :: (MESH:D009135,Disease) :: ['myopathy']


abstract: BACKGROUND: The painDETECT questionnaire (PD-Q) is a fast and uncomplicated way to ascertain the percentage of @entity9 in 'total @entity158 ' and is designed to detect @entity158 . The purpose of this randomized, prospective study is to compare, with the assessment of the @entity13749 , the efficacy of interlaminar (IL) and transforaminal (TF) @entity134 injections in @entity1 with unilateral chronic lumbar radicular @entity158 . METHODS: @entity1 were treated fluoroscopically with epidural @entity230 , using the IL or TF method and with confirmation of the epidural space by contrast, using random computerized classification. The @entity1 received a series of three IL or TF epidural @entity134 injections (ESI) at 2-week intervals. The @entity1 were monitored for 6 months from the first @entity134 injection. RESULTS: By analyzing the average values of the total sum of points in the PD-Q a dropping trend is confirmed for both groups. The trend equation (y = -1.1393x + 25.269) for the TF ESI shows a faster recovery than the IL ESI (y = -0.8089x + 26.654). The statistically significant difference in the two groups is proved between the first and the sixth visit (IL ESI, p = 0.014; TF ESI, p = 0.001). There is no statistically significant difference in the efficiency of the two dosages and the volumes of @entity230 between the IL and TF distribution of @entity230 . CONCLUSIONS: @entity230 are efficient; besides alleviating the overall @entity158 , they also reduce the @entity9 , whether it is distributed epidurally by the IL or TF approach.

title: painDETECT questionnaire and lumbar epidural XXXX injection for chronic radiculopathy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'neuropathic pain components in back pain']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['Steroids', 'steroids']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'neuropathic component in chronic lumbar radicular pain']

answer: @entity134 :: (CHEBI:35341,Chemical) :: ['steroid']


abstract: @entity0 tissue from 95 @entity1 was simultaneously assayed for three receptors: cytosolic @entity172 (CER), cytosolic @entity1420 (CPR), and nuclear @entity172 (NER). The main objective was to determine whether the addition of NER assay to the currently accepted practice with only CER and CPR could improve the predictive capacity of receptors. Forty-two @entity1 were studied for response to hormone therapy and 95 @entity1 were studied for survival; the median follow-up period was 73 months (range, 8 to 300 months). The incidence of CER+, CPR+, and NER+ was 74%, 70%, and 52%, respectively. Each receptor appeared more frequently, although not significantly so, in higher age groups. Forty percent of @entity5 had all three receptors positive and 14% had all negative; the remaining @entity5 showed all possible combinations of receptors. Both the rate of response and survival curves among 70 @entity1 with CER+ did not show any significant difference whether NER was positive or negative. Also, among 38 @entity1 with CER+, CPR+, and NER+, there was no significant difference in the clinical outcome as compared to 17 @entity1 with CER+, CPR+, and NER-. Among 25 @entity1 with CER- the rare occurrence of NER+ in only three @entity1 did not suggest any clinical implication. It is concluded, therefore, that on overall clinical grounds the current series does not support the addition of NER assay whenever data is available on both CER and CPR.

title: A clinical evaluation of nuclear @entity172 receptors combined with cytosolic @entity172 and XXXX receptors in @entity0 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

answer: @entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']


abstract: OBJECTIVE: The goals of this study were to examine the role of dissociation and @entity308 as possible mediators of the relationship between several forms of childhood @entity130 and bulimic symptomatology and to explore potential ethnic differences in these relationships. METHOD: Four hundred seventeen female undergraduates participated in this cross-sectional study. They completed measures of dissociative, @entity308 , and bulimic symptoms, and childhood @entity130 . Experiences of multiple forms of childhood @entity130 were measured, including physical abuse, @entity734 , physical neglect, and emotional neglect. However, only @entity734 was correlated with bulimic symptoms at p<.01. Therefore, other forms of @entity130 were excluded from the analyses to control for Type I error. RESULTS: Dissociation was not associated with @entity734 after controlling for @entity308 ; therefore, tests of dissociation as a mediator were discontinued. @entity308 was significantly associated with @entity734 after controlling for dissociation. @entity734 was significantly associated with @entity6426 . Finally, @entity734 and @entity308 together were significantly associated with @entity6426 after controlling for dissociation. However, @entity734 became nonsignificant when entered with @entity308 , indicating that @entity308 mediated the relationship between @entity734 and bulimic symptoms. There were no ethnic differences in this relationship. CONCLUSIONS: It appears that among @entity1 who have experienced childhood @entity734 , @entity308 is more strongly associated with unhealthy eating behaviors than is dissociation. Results also suggest that @entity734 is a form of childhood @entity130 particularly relevant to @entity6426 .

title: The role of @entity308 and dissociation in the relationship between childhood XXXX and bulimic symptoms among ethnically diverse female undergraduates.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'depressive']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['Emotional abuse', 'emotional abuse', 'sexual abuse, emotional abuse']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: Upon fertilization, a sperm nucleus reorganizes to become a male pronucleus. This reorganization includes breakdown and reformation of the nuclear envelope of the male pronucleus. In this study, we used a maternally encoded nuclear lamina protein, YA, in parallel with another lamina protein, @entity44539 , as probes to study the formation of the male pronuclear lamina in @entity238 . Ectopically expressed YA is present in the nuclear envelopes of spermatocytes, but not in mature sperm, similar to endogenous @entity44539 . This suggests that the nuclear envelope of @entity238 sperm differs from that of somatic cells. Upon fertilization, YA and @entity44539 are recruited to the periphery of the male-derived nucleus before or during the early stages of migration by the male pronucleus. Using a paternal effect mutation, snky, we found that recruitment of lamina proteins to the male pronucleus requires, and probably accompanies, reorganization of the sperm nucleus. In order to identify factors that affect the recruitment of nuclear lamina proteins to the male pronucleus, we examined the subcellular localization of YA and @entity44539 in mutant embryos defective for the function of either the male pronucleus (mh, @entity44540 , and pal or both pronuclei (gnu, png, and plu). None of these mutations affect the recruitment of YA or @entity44539 to the male pronuclear envelope, suggesting that the mutations affect processes independent of, or after, reorganization of the nuclear envelope. Double mutant analyses between Ya and gnu suggest that YA plays a role in the nuclear envelope permissive for rounds of DNA replication.

title: Formation of the male pronuclear lamina in XXXX .

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila', 'Drosophila melanogaster']

answer: @entity238 :: (7227,Species) :: ['Drosophila melanogaster']


abstract: A total of 145 @entity114 -nonsusceptible @entity328 strains were isolated from young carriers in Greece and analyzed by antibiotic susceptibility testing, serotyping, restriction fragment end labeling (RFEL), and @entity114 -binding protein ( @entity3218 ) genotyping. The serotypes 23A and 23F (54%), 19A and 19F (25%), 9V (5%), 15A, 15B, and 15C (4%), 6A and 6B (4%), and 21 (4%) were most prevalent in this collection. Fifty-three distinct RFEL types were identified. Sixteen different RFEL clusters, harboring 2 to 32 strains each, accounted for 82% of all strains. Eight of these genetic clusters representing 60% of the strains were previously identified in other countries. A predominant lineage of 66 strains (46%) harboring five RFEL types and the serotypes 19F and 23F was closely related to the pandemic clone Spain(23F)-1 (genetic relatedness of > or =85%). Another lineage, representing 11 strains, showed close genetic relatedness to the pandemic clone France(9V)-3. Another lineage of 8 serotype 21 strains was Greece specific since the RFEL types were not observed in an international collection of 193 genotypes from 16 different countries. Characterization of the @entity3218 genes pbp1a, pbp2b, and pbp2x revealed 20 distinct @entity3218 genotypes of which @entity3218 type 1-1-1, initially observed in the pandemic clones 23F and 9V, was predominantly present in 11 RFEL types in this Greek collection of @entity114 -nonsusceptible strains (55%). Sixteen @entity3218 types covering 52 strains (36%) were Greece specific. This study underlines the strong contribution of @entity114 -resistant international clones to the prevalence and spread of @entity114 -nonsusceptible pneumococci among young @entity1 in Greece.

title: Molecular epidemiology of @entity114 -nonsusceptible XXXX among @entity1 in Greece.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

answer: @entity328 :: (1313,Species) :: ['Streptococcus pneumoniae']


abstract: OBJECTIVE: This study was conducted to evaluate the effectiveness of self-fashioned Gynemesh for the concomitant treatment of @entity322 and @entity3133 , and the factors involved in @entity2681 . MATERIALS AND METHODS: From March 2004 to September 2006, 65 @entity1 with @entity322 , with or without pelvic organ prolapse or prior surgery for prolapse or @entity322 , were recruited for this study. A self-fashioned Gynemesh was used for the concomitant treatment of @entity322 and @entity3133 . @entity1 in this study underwent suburethral slingplasty and/or concomitant pelvic reconstructive operations. A general linear model univariate analysis was performed to assess the relationships between @entity2681 and various variables. RESULTS: The mean postoperative follow-up was 33 months. Those @entity1 with anterior wall prolapse presented as completely cured postoperatively. The cure rate for @entity322 was 80%, and the improvement rate was 17%. @entity365 was discovered in four @entity1 (6%) during the postoperative follow-up. These four @entity1 remained continent after the removal of the eroded mesh. The interactive effects for @entity2681 by a general linear model analysis were menopausal @entity1 with @entity1442 (p < 0.05) and @entity1 with @entity1442 with concomitant sacrospinous ligament fixation (p < 0.05). CONCLUSION: We found that using self-fashioned Gynemesh for tension-free suburethral and anterior vaginal slingplasty provided a high success rate (97%) in the 3 years of follow-up. Mechanical rejection may be one of the causes of @entity365 .

title: Suburethral slingplasty using a self-fashioned Gynemesh for treating XXXX and @entity3133 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'incontinence']

entities_list: @entity2681 :: ('MESH:D014077', 'Disease') :: ['mesh erosion']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced anterior vaginal wall prolapse']

entities_list: @entity3133 :: ('MESH:D014596', 'Disease') :: ['anterior vaginal wall prolapse']

entities_list: @entity365 :: ('MESH:D014627', 'Disease') :: ['vaginal mesh erosion', 'Vaginal mesh erosion']

answer: @entity322 :: (MESH:D014549,Disease) :: ['urinary incontinence']


abstract: PURPOSE: Multidisciplinary teams have become increasingly desirable for managing complex disease but little objective data exist to support this approach. The aim of our study was to determine the impact of a multidisciplinary clinic on the management of @entity14 . METHODS: Data were prospectively collected on all @entity1 with newly diagnosed @entity14 referred to the multidisciplinary clinic at our institution in 2009 and compared to a control group of all @entity1 managed outside the clinic from 2008 to 2009. Comprehensiveness of preoperative evaluation was determined by frequency of abdominal and chest CT, @entity787 testing, and transrectal ultrasound. Access to multimodal care was measured by frequency of oncology consultation and treatment, advanced pathology testing, genetics counseling, and trial enrollment. RESULTS: Two hundred eighty-eight @entity1 met inclusion criteria; 88 @entity1 were referred to the clinic (40 preoperative, 48 postoperative) and 200 @entity1 were managed outside. Complete preoperative evaluation was accomplished three times more frequently in clinic @entity1 (85 vs. 23 %, p < 0.0001) with significant improvements in all parameters. Enhanced access to multimodal therapy was demonstrated in clinic @entity1 by increased frequency of oncology consultation (98.9 vs. 61.5 %, p < 0.0001) and treatment (62.5 vs. 41.5 %, p = 0.02), advanced pathology testing (29.6 vs. 10.6 %, p = 0.0001), and genetics counseling (6.8 vs. 1.6 %, p = 0.28). Clinic @entity1 also received significantly higher rates of neoadjuvant therapy for stage II or greater @entity5 (82.6 vs. 30.9 %, p = 0.0001). CONCLUSIONS: Multidisciplinary clinic management of @entity14 is associated with a significantly more complete preoperative evaluation as well as improved access to multimodal therapy.

title: Multidisciplinary management of XXXX enhances access to multimodal therapy and compliance with National @entity5 Network (NCCN) guidelines.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: The aim of this work was to correlate anatomic and urodynamic measures with function following bladder neck surgery. Eighty-seven @entity1 who underwent bladder neck surgery at two tertiary academic medical centers in the southeastern U.S. were studied in this prospective outcomes analysis. Preoperative and 6-week and 6-month postoperative status was assessed with urodynamic testing, physical examination, and condition-specific quality of life instruments. Correlations of @entity11044 (quantified by pressure transmission ratio, PTR, determinations) and urethral support (quantified by urethral axis measurements) with functional status were determined. At 6 weeks, 50% of the subjects with inadequate @entity3885 (PTR < 90%) had genuine stress incontinence (GSI) compared to 5% of those with PTR >/= 90% (P = .00002). Of those with @entity3885 (PTR > 110%), 32% had @entity1344 ( @entity1344 ) and 47% had @entity409 ( @entity409 ) compared to 6% and 24%, respectively, of those with PTR </= 110% (P = .006 and P = .04). At 6 months, subjects with @entity3885 were more likely to have @entity409 than other subjects (75% vs. 27%, P = .001). Those with optimal @entity3885 (PTR >/= 90% but </= 110%) were more likely to have normal function (no GSI, no @entity1344 , and no @entity409 ) than those with higher or lower PTRs (59% vs. 34%, P = .04). @entity6369 measurements did not correlate with functional status at either follow-up session. The magnitude of @entity11044 is related to function after bladder neck surgery. @entity3885 is associated with @entity1344 and @entity409 , inadequate obstruction with GSI, and optimal obstruction with normal function. Neurourol. Urodynam. 18:629-637, 1999.

title: Understanding lower urinary tract function in XXXX soon after bladder neck surgery. Continence Program for @entity1 Research Group.

entities_list: @entity6369 :: ('MESH:D014526', 'Disease') :: ['Urethral axis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['EPD', 'emptying phase dysfunction']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['excessive obstruction', 'Excessive obstruction', 'dynamic obstruction']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['DI', 'detrusor instability']

entities_list: @entity11044 :: ('MESH:D014524', 'Disease') :: ['dynamic urethral obstruction']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND AND AIMS: Infiltration of the hepatic veins in the @entity4281 can lead to the development of the @entity3181 . The medical and surgical treatment of this condition is generally unsatisfactory. The results of successful interventional treatment with percutaneous stent implantation in the hepatic veins are reported. METHODS: Using a transjugular approach, metal mesh stents (Boston Scientific, Medi-Tech Accuflex 8/60 mm) were placed in the median and left hepatic veins of a 53 year old @entity1 . After the intervention, oral chemotherapy with @entity3753 (2 x 400 mg/day) was continued, but no anticoagulants were given. RESULTS: Stent placement was performed without complications. The clinical picture improved rapidly: normalisation of portal blood flow was confirmed by Doppler ultrasound and there was improvement of liver function, reduction of oesophageal varices, and disappearance of @entity843 . A follow-up examination at 15 months showed no evidence of @entity432 . CONCLUSIONS: Treatment of portal @entity101 in @entity4281 of the liver is problematic. In selected @entity1 with portal @entity101 secondary to hepatic vein stenoses but no @entity82 , percutaneous stent placement in the hepatic veins represents a promising treatment alternative.

title: @entity4281 of the liver: percutaneous stent therapy in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity3753 :: ('MESH:D015766', 'Chemical') :: ['albendazole']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity3181 :: ('MESH:D006502', 'Disease') :: ['Budd-Chiari syndrome']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['stent occlusion']

entities_list: @entity4281 :: ('MESH:C536591', 'Disease') :: ['alveolar echinococcosis']

answer: @entity3181 :: (MESH:D006502,Disease) :: ['Budd-Chiari syndrome']


abstract: UNASSIGNED: @entity1 activities have altered the biogeochemical cycle of @entity349 ( @entity5332 ) since precolonial times, and anthropogenic activities will continue to perturb the natural cycle of @entity5332 . Current estimates suggest the atmospheric burden is three to five times greater than precolonial times. @entity5332 in the upper ocean is estimated to have doubled over the same period. The Minamata convention seeks to reduce the impact @entity1 activities have on @entity5332 releases to the environment. A number of the Articles in the Convention concern the development of detailed inventories for @entity5332 emissions and releases. Using the global @entity5332 chemical transport model, ECHMERIT, the influence of the anthropogenic emission inventory (AMAP/UNEP, EDGAR, STREETS) on global @entity5332 deposition patterns has been investigated. The results suggest that anthropogenic @entity5332 emissions contribute 20-25% to present-day @entity5332 deposition, and roughly two-thirds of primary anthropogenic @entity5332 is deposited to the world's oceans. Anthropogenic @entity5332 deposition is significant in the North Pacific, Mediterranean and Arctic. The results indicate immediate reductions in @entity5332 emissions would produce benefits in the short term, as well as in the long term. The most impacted regions would be suitable to assess changes in @entity5332 deposition resulting from implementation of the Minamata convention.

title: A Modeling Comparison of @entity349 Deposition from Current Anthropogenic XXXX Emission Inventories.

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

answer: @entity349 :: (MESH:D008628,Chemical) :: ['Mercury']


abstract: In recent years, the treatment of @entity792 has been significantly advanced by the use of biological agents. However, some biologics are accompanied with severe side effects, including @entity378 and other types of @entity281 . There is thus a critical need for nonsystemic and lesion-specific methods of delivering these therapeutic agents. We attempted to treat a @entity19 model of @entity625 by using T cells that expressed a regulatory molecule and were specifically directed to the inflamed paw. To this end, we first identified the @entity12810 alphabeta genes accumulating in the inflamed paw of @entity19 with @entity1753 ( @entity1753 ) by a combination of single-strand chain polymorphism analysis of @entity12810 and single-cell sorting. We identified an expanded clone B47 which is autoreactive but is not specific to type II collagen. In vivo, @entity12810 genes from B47-transduced T cells accumulated in the inflamed paw. Injection of cells cotransduced with the B47 and soluble TNFRIg genes resulted in a significant suppression of @entity1753 . The suppression was correlated with the amount of TNFRIg transcripts in the hind paw, not with the serum concentrations of TNFRIg. Moreover, T cells cotransduced with the B47 and intracellular @entity3744 genes significantly suppressed @entity1753 with reductions in @entity637 , @entity636 , and @entity635 expression and @entity79 . T cells cotransduced with B47 and @entity3744 genes also suppressed the progression of established @entity1753 . Therefore, immunosuppressive therapy with autoreactive @entity12810 is a promising therapeutic strategy for @entity625 whether the TCRs are used to deliver either soluble or intracellular suppressive molecules.

title: Gene therapy of @entity625 with XXXX isolated from the inflamed paw.

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen-induced arthritis', 'CIA']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone destruction']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

answer: @entity12810 :: (328483(Tax:10090),Gene) :: ['TCR']


abstract: BACKGROUND: @entity519 results in the development of @entity120 and subsequent @entity712 . A role of the @entity43312 system in the pathogenesis of @entity120 and @entity6980 has been suggested. METHODS AND RESULTS: @entity19 with targeted deficiency of the gene encoding tissue-type @entity43312 activator ( @entity35311 (-/-)), urokinase-type @entity43312 activator ( @entity16372 (-/-)), @entity16372 receptor (u-PAR(-/-)), or @entity43312 (plg(-/-)) were subjected to @entity519 conditions. @entity519 caused a significant 2.5-fold rise in right ventricular pressure in wild-type @entity19 . Deficiency of @entity16372 or @entity43312 prevented this increase in right ventricular pressure, @entity35311 (-/-) @entity19 showed changes that were fully comparable with wild-type @entity19 , and u-PAR(-/-) @entity19 showed a partial response. @entity519 induced an increase in smooth muscle cells within pulmonary arterial walls and a vascular rarefaction in the lungs of wild-type but not of @entity16372 (-/-) or plg(-/-) @entity19 . Elastic lamina fragmentation, observed in @entity519 wild-type but not in @entity16372 or @entity43312 -deficient @entity19 , suggested that proliferation of vascular smooth muscle cells was dependent on @entity16372 -mediated elastic membrane degradation. @entity519 -induced right ventricular remodeling in wild-type @entity19 , characterized by cardiomyocyte @entity1184 and increased collagen contents, was not seen in @entity16372 (-/-) and plg(-/-) @entity19 . CONCLUSIONS: Loss of the @entity16372 or @entity43312 gene protects against the development of @entity519 -induced @entity120 and @entity6980 . These observations point to an essential role of @entity16372 -mediated plasmin generation in the adaptive response to chronic @entity519 and the occurrence of @entity358 .

title: Deficiency of urokinase-type @entity43312 activator-mediated plasmin generation impairs vascular remodeling during @entity519 -induced @entity120 in XXXX .

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['right heart failure']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity6980 :: ('MESH:D066253', 'Disease') :: ['pulmonary vascular remodeling']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['Chronic hypoxia', 'Hypoxia', 'hypoxic', 'hypoxia']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['hypoxic pulmonary vascular disease']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: The risk of @entity65 in a @entity6 @entity1 is similar to that in a nondiabetic @entity1 with a history of @entity583 . Although intensive control of glycemia achieved by conventional antidiabetic agents decreases microvascular complications such as @entity989 and @entity8 , no marked effect has been reported on macrovascular complications or all-cause mortality. Evidence from VADT, ACCORD, and ADVANCE would suggest that glycemic control has little effect on macrovascular outcomes. Moreover, in the case of ACCORD, intensive glycemic control may be associated with an increased risk of mortality. There is sufficient evidence that suggests that postprandial @entity4854 may be an independent risk factor for @entity65 in @entity6 @entity1 . However, there are no prospective clinical trials supporting the recommendation that lowering postprandial blood @entity413 leads to lower risk of cardiovascular outcomes. @entity34426 is a short-acting insulinotropic agent used in @entity164 2 @entity6 treatment. It has a rapid stimulatory effect on insulin secretion and reduces postprandial plasma @entity413 level in @entity1 with @entity164 2 @entity6 . Because of its short action time, it is unlikely to exert adverse effects related to @entity4053 early in the morning and between meals. @entity34426 reduces excess oxidative stress and @entity32 , plays a cardioprotective role, and improves postprandial @entity209 . Moreover, @entity34426 add-on therapy with @entity12098 favorably affects the vascular endothelial function in @entity164 2 @entity6 @entity1 . These data suggest that @entity34426 plays a potentially beneficial role in the improvement of postprandial @entity4854 in @entity164 2 @entity6 @entity1 and can be used to prevent @entity65 . Although the results of long-term, randomized, placebo-controlled trials for determining the cardiovascular effects of @entity34426 on clinical outcomes are awaited, this review is aimed at summarizing substantial insights into this topic.

title: Postprandial XXXX and endothelial function in @entity164 2 @entity6 : focus on @entity34426 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity34426 :: ('MESH:C087255', 'Chemical') :: ['mitiglinide', 'Mitiglinide']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity12098 :: ('MESH:C060836', 'Chemical') :: ['pioglitazone']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease', 'cardiovascular diseases', 'cardiovascular complication']

answer: @entity4854 :: (MESH:D006943,Disease) :: ['hyperglycemia']


abstract: BACKGROUND: Irrigation of the lacrimal duct with @entity1346 tube intubation (TWS/S) remains the preferred treatment in persisting connatal lacrimal duct stenosis ( @entity23673 ). The timepoint of operation is however discussed controversely. On the one hand, it is recommended to wait for spontaneous opening of the lacrimal duct within the first year of life, on the other hand a later operation may trigger inflammatory changes within the lacrimal duct system influencing the success rate of the operation negatively. The aim of this study was to analyze the best time point of operation regarding the long-term success rate of the operation. @entity1 /MATERIALS AND METHODS: 411 lacrimal ducts of 316 @entity1 with @entity23673 between 0 and 48 months of age (164 male, 156 female), who had undergone TWS with S because of @entity23673 at a tertiary eye care centre between 2007-2011 were included in this study. The @entity1 were divided into 6 groups of age (0-6, 7-12, 13-18, 19-24, 24-36, > 36 months) at the time of operation. The operative success was retrospectively evaluated after 36 months. The groups were compared and differences in late success rate analyzed statistically. RESULTS: The average success of operation of TWS/S in @entity23673 was 89 % (366 of 411 lacrimal ducts). The success rate of operation differed between the groups. If operated at the age of 0-6 months the operation was successful in 94 %, at the age 7-12 months in 91 %, between 13-18 months in 90.5 %, from 19-24 months in 88 %, and from 25-36 months in only 84.5 %. The success rate was therewith at the age of 25-36 months significantly lower than at the age of 0-6 months (p < 0.05). CONCLUSION: TWS/S in @entity23673 has overall a very high rate of success. The success of the operation decreases however in correlation with age at time of operation and shows with > 25 months significantly poorer results than at 0-6 months. The choice of the best time point for operation merits further investigation.

title: [Impact of age on success rate of lacrimal duct irrigation with XXXX tube intubation in connatal lacrimal duct stenosis].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'PATIENTS']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

answer: @entity1346 :: (MESH:D012828,Chemical) :: ['silicone']


abstract: BACKGROUND: We used a simple semi-quantitative radiographic scoring system for a controlled prospective study of long term @entity288 in @entity10070 , conducted by the British @entity1514 Society. METHODS: Radiographic opacities were described in 4 categories: reticulo-nodular shadows [R], mass opacities [M], confluence [C], and shadows associated with possible @entity3794 [F]. The extent of each type was scored on a 0-4 scale by quartiles, and profusion by a 0-4 scale as absent, minimal (just perceptible), mild moderate or gross. Combined scores for each film were derived by multiplying the extent and profusion for each type of opacity. In the study 149 @entity1 were examined at entry and periodically over a 5-year period. Using the whole study population we examined the relationship between the radiographic scores for extent and profusion, how predominant types change with time and how the scores correlated with other indices of disease severity. RESULTS: R was the predominant abnormality throughout the study with a strong correlation between extent and profusion. Significant correlations in the expected directions were demonstrated between the R and F scores and a dyspnoea score, spirometry and TLCO, both at study entry, after 6 months and after 5 years. Similarly, there were significant relations between changes in spirometry and TLCO over five years and changes in R and F Scores. CONCLUSION: This scoring system would seem to be suitable, perhaps after further validation work, for other prospective clinical studies.

title: A simple radiographic scoring method for monitoring XXXX : relations between radiographic scores, dyspnoea grade and respiratory function in the British @entity1514 Society Study of Long-Term Corticosteroid Treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis']

entities_list: @entity10070 :: ('MESH:D017565', 'Disease') :: ['pulmonary sarcoidosis']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity10070 :: (MESH:D017565,Disease) :: ['pulmonary sarcoidosis']


abstract: We investigated the prognostic value of some variables of effective @entity3102 treatment for metastatic castration-resistant @entity263 (mCRPC). In total, 163 @entity1 with mCRPC were eligible, receiving @entity3102 200-400 mg three times daily with replacement doses of @entity229 . Progression-free survival (PFS) was calculated from the beginning of the @entity3102 therapy to the onset of disease progression. The prognostic value of different variables for PFS was assessed by Cox regression analysis. The median PFS was 2.6 months (0.5-8.6 months) for these patients. The serum @entity251 level changed during therapy, which decreased when the @entity1486 (PSA) declined; the serum @entity251 level increased as the levels of PSA relapsed. The median PFS values for @entity1 associated with different factors were the following: 1.4 and 3.5 months for a nadir PSA of >=  0.2 and <0.2 ng ml(-1), respectively (hazard rate (HR)=4.767, P<0.001); 3.1 and 1.6 months for a baseline @entity251 of >=  0.1 and <0.1 ng ml(-1), respectively (HR=2.865, P=0.012); 2.8 and 1.9 months for a baseline haemoglobin of >=  120 and <120 g l(-1), respectively (HR=1.605, P<0.001); and 3.0 and 1.9 months for a PSA doubling time (PSADT) of >=  2.0 and <2.0 months, respectively (HR=1.454, P=0.017). A risk model was constructed according to the four factors that divided @entity1 into three subgroups of low risk (0-1 factors), moderate risk (2 factors) and high risk (3-4 factors) with PFS values of 3.6, 3.0 and 1.4 months, respectively (HR=1.619, P<0.001). A nadir PSA of >=  0.2 ng ml(-1), a baseline @entity251 of <0.1 ng ml(-1), a baseline haemoglobin of <120 g l(-1) and a PSADT of <2 months were associated with a poor PFS. This risk model could provide evidence to predict the survival benefit of @entity3102 therapy.

title: The prognostic factors of effective @entity3102 treatment for metastatic castration-resistant XXXX : who can benefit from @entity3102 therapy?

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity3102 :: ('MESH:D007654', 'Chemical') :: ['ketoconazole']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: To test if functional electrical stimulation (FES) can enhance the recovery of @entity2045 function during @entity64 rehabilitation. METHODS: Open-label block-randomized trial, begun during inpatient rehabilitation and continued at the @entity1 ' home. @entity1 were assigned to either FES combined with task-specific @entity2045 rehabilitation (n = 7) or a control group that received task-specific therapy alone (n = 8) over 12 weeks. Outcome measures . Hand function (Box _ Blocks, B _ B; Jebsen-Taylor light object lift, @entity1619 ) and motor control (modified Fugl-Meyer, mF-M) were video-recorded for both upper extremities at baseline, 4, 8, and 12 weeks. RESULTS: B_B mean score at 12 weeks favored (P = .049) the FES group (42.3 +/- 16.6 blocks) over the control group (26.3 +/- 11.0 blocks). The FES group @entity1619 task was 6.7 +/- 2.9 seconds and faster (P = .049) than the 11.8 +/- 5.4 seconds of the control group. Mean mF-M score of the FES group at 12 weeks was 49.3 +/- 5.1 points out of 54, compared to the control group that scored 40.6 +/- 8.2 points (P = .042). All @entity1 regained hand function. CONCLUSION: Upper extremity task-oriented training that begins soon after @entity64 that incorporates FES may improve @entity2045 functional use in @entity1 with mild/moderate paresis more than task-oriented training without FES.

title: Functional electrical stimulation enhancement of XXXX functional recovery during @entity64 rehabilitation: a pilot study.

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'early stroke']

answer: @entity2045 :: (MESH:D009207,Disease) :: ['upper extremity']


abstract: The effect of pregnancy has been studied in 10 mothers with @entity2360 . Three were presymptomatic but had the typical biochemical lesion, two of these were receiving @entity2361 treatment at the time of conception, the third had yet to be diagnosed. The remaining seven mothers had had symptoms of @entity2360 and had been receiving treatment for periods ranging from two and a half to 19 years. These mothers had 15 pregnancies between them, 13 went to full term but two ended prematurely at 26 and 30 weeks. In only one did pregnancy have an unfavourable effect on the @entity2360 ; this mother had been on @entity2361 for only two and a half years in a suboptimal dose because of drug induced thrombocytopoenia. In addition she had extensive oesophageal varices and pregnancy was complicated by toxaemia. The other nine @entity1 remained well and two had three pregnancies each. On six occasions @entity2361 was taken throughout pregnancy, but in seven it was discontinued from the sixth to the twelfth week. All 15 babies were normal but one died of extreme prematurity (26 weeks gestation). Pregnancy does not appear to be contraindicated in well treated @entity2360 and @entity2361 does not seem to pose an undue risk to the foetus.

title: Pregnancy in XXXX .

entities_list: @entity2360 :: ('MESH:D006527', 'Disease') :: ["Wilson's disease"]

entities_list: @entity2361 :: ('MESH:D010396', 'Chemical') :: ['penicillamine']

answer: @entity2360 :: (MESH:D006527,Disease) :: ['Wilson's disease']


abstract: INTRODUCTION: The most frequent complication of A (H1N1) @entity683 and the leading cause of @entity204 was @entity55 with a primary viral or mixed viral and bacterial etiology. 182 @entity1 had died because of a pandemic @entity683 in Poland by 31st July 2010. MATERIAL AND METHODS: A retrospective study of 6 fatal cases of pandemic @entity683 , aged 23-41, including 3 @entity1 , hospitalised between November 2009 and February 2011 in different Polish medical centres. RESULTS: We present the clinical course of 6 late diagnosed cases of A (H1N1) @entity683 . All @entity1 presented @entity1109 in the beginning. 4/6 @entity1 had severe disease risk factors: pregnancy, @entity625 , @entity2883 and @entity28 . All @entity1 were seen by doctors, no one had received antiviral therapy, 4/5 were treated with antibiotics before they were hospitalized. One @entity1 had @entity580 . @entity1 were admitted to the hospital on the 3rd to 8th day of the disease. They received @entity684 treatment on the 4th to 9th day. All @entity1 developed @entity55 complicated by acute @entity649 . @entity204 appeared between the 4th and 27th day after the onset of symptoms. Autopsies were performed in 5 cases and revealed @entity548 in 2 @entity1 . CONCLUSION: Delayed diagnosis and antiviral treatment initiation has a significant impact on mortality in A (H1N1) @entity683 . During the @entity683 , @entity1 presenting typical symptoms should always be suspected of having @entity683 . Antiviral treatment has to be initiated immediately, especially if there are risk factors of severe disease.

title: The clinical course of late diagnosed fatal cases of A (H1N1) XXXX in Poland.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient']

entities_list: @entity684 :: ('MESH:D053139', 'Chemical') :: ['oseltamivir']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic pneumonia']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['typical flu-like symptoms']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza', 'influenza epidemic']

entities_list: @entity2883 :: ('MESH:D014890', 'Disease') :: ['Wegener granulomatosis']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infection']

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza']


abstract: BACKGROUND: Intravitreal anti- @entity7 ( @entity7 ) therapy with ranibizumab has been shown to be an effective therapeutic option for foveal @entity1103 ( @entity1103 ). This prospective study evaluated the functional and morphological retinal changes after intravitreal ranibizumab treatment. MATERIAL AND METHODS: A consecutive prospective series of @entity1103 @entity1 treated with intravitreal ranibizumab were examined before and after 3 and 6 months of intravitreal ranibizumab therapy. Best-corrected visual acuity (BCVA) according to the ETDRS protocol, retinal thickness in the macular area and @entity989 ( @entity989 ) measured with spectral-domain optical coherence tomography (SD-OCT) was determined. In addition, microperimetric functional macular mapping was determined before therapy and 4 weeks after the third injection. RESULTS: A total of 41 eyes from 33 @entity1 were evaluated. During the 6-month observational period @entity1 received a mean number of 5.2 injections. The mean BCVA increased significantly from 26        14 to 33        13 letters 4 weeks after the third injection and to 34        14 letters 6 months after starting the treatment. The mean @entity989 decreased significantly from 509        147    m to 385        121    m after the third injection and to 383        110    m after 6 months. After 3 injections, the thickness of the most prominent central retinal area was less than 445    m in 68.3% of @entity1 and after a further 3 months of treatment in 78.0%. CONCLUSION: The presented data demonstrate that intravitreal ranibizumab is effective for @entity1103 in everyday clinical practice and results are comparable to those of registration trials. After three initial injections significant structural and functional improvements were observed in a considerable number of @entity1 .

title: [Ranibizumab in XXXX . Evaluation of functional and morphological aspects].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['CRT', 'central retinal thickness']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['DME', 'diabetic macular edema']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

answer: @entity1103 :: (MESH:D008269,Disease) :: ['diabetic macular edema']


abstract: @entity14495 are aggressive, @entity8650 and their classification among @entity320 or @entity242 is still undetermined due to their clinical, pathologic, and molecular properties found in both types of @entity5 . This is a retrospective study of 52 @entity1 with CCS seen between April 1979 and April 2005 in two institutions. The @entity12569 fusion transcript was studied in 31 @entity1 and an activating mutation of the @entity817 or @entity8497 gene was researched in 22 @entity1 . 30 @entity1 and 22 @entity1 , with a mean age of 33 were studied. Forty-three @entity5 (82.69%) were located in the extremities, specially the foot (19 @entity5 ). Median initial @entity5 size was 4.8   cm (1 to 15   cm). @entity39 involving more than 50% of the @entity5 cells was found in 14 cases (26.92%). High mitotic rate (>10) was found in 25 cases (48.07%). The @entity37117 translocation was found in 28 (53.84%) of 31 @entity1 studied, and mutation of @entity817 or @entity8497 was found in only 2 of 22 @entity1 analyzed cases (3.84%). Among the @entity5 -associated parameters, only @entity5 size (>4   cm) emerged as a significant prognostic factor. Forty-nine @entity1 had a localized disease at diagnosis (94.23%) and underwent surgical resection immediately (90%) or after neoadjuvant chemotherapy (CT) (10%). Various CT regimens were used in 37 @entity1 (71.15%) with no significant efficacy. The 5- and 10-year OS rates were 59% and 41%, respectively. @entity5 size was the only emerging prognosis factor in our series. Complete surgical resection remains the optimal treatment for this aggressive chemoresistant @entity5 .

title: XXXX ( @entity320 ) of soft parts: a clinicopathologic study of 52 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity8650 :: ('MESH:D012983', 'Disease') :: ['rare soft tissue tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['Necrosis']

entities_list: @entity14495 :: ('MESH:D018227', 'Disease') :: ['Clear cell sarcomas']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity14495 :: (MESH:D018227,Disease) :: ['Clear cell sarcoma']


abstract: As amniotes diversified, mammals may have modified mechanisms of cellular pluripotency along with the acquisition of a placenta. What then defined pluripotent states in the ancestral amniotes? To study the evolutionary background of pluripotency in amniotes, we tested the effects of extracellular effectors on primary culture cells from avian and reptile embryos in serum-free medium. When treated with a combination of a @entity8047 inhibitor and a GSK3 inhibitor (2i condition), @entity1573 early embryos formed domed colonies (DCs), which were morphologically indistinguishable from the colonies formed by @entity19 and @entity35 na  ve embryonic stem cells. However, no DCs formed when cells from further-developed embryos were cultured in the 2i condition, indicating that there is a clear boundary of DC-forming ability at around the stage of primitive streak elongation. Quail embryos at the blastoderm and cleavage stages also formed DCs in the 2i condition, which is consistent with the notion that the appearance of DCs corresponds with the presence of pluripotent cells in embryos. Gecko blastoderms also formed DCs in the 2i condition, but gastrulas did not. ERK activation by bFGF caused an effect opposite to that of the 2i condition, namely, it dispersed colonies of cells even from early embryos in all species examined. These results suggest that the regulation of pluripotency by FGF/ERK signaling may date back at least to the common ancestor of mammals, birds, and reptiles. However, gene expression analysis indicated the possibility that @entity1 pluripotency transcription factors function differently in non- @entity1 amniotes.

title: Inhibition of XXXX and GSK3 supports ES cell-like domed colony formation from avian and reptile embryos.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

answer: @entity8047 :: (5609,Gene) :: ['MEK']


abstract: BACKGROUND: Most NSAIDs function by inhibiting biosynthesis of @entity1421 by inhibition of @entity9859 and/or @entity2247 . Since @entity9859 has a protective function in the gastro-intestinal tract (GIT), non-selective inhibition of both cycloxy genases leads to moderate to severe gastro-intestinal intolerance. Attempts to identify selective inhibitors of @entity2247 , led to the identification of @entity12698 and @entity13586 . However, long-term use of these drugs has serious adverse effects of sudden @entity583 and @entity715 . Drug-mediated imbalance in the levels of @entity4770 (PGI(2)) and @entity2404 ( @entity3447 ) with a bias towards TXA(2) may be the primary reason for these events. This resulted in the drugs being withdrawn from the market, leaving a need for an effective and safe anti-inflammatory drug. METHODS: Recently, the focus of research has shifted to enzymes downstream of COX in the prosta glandin biosynthetic pathway such as @entity1421 synthases. Microsomal @entity1421 synthase-1 ( @entity8207 ) specifically isomerizes @entity14297 to @entity1421 , under inflammatory conditions. In this review, we examine the biology of @entity8207 and its role in disease. Progress in designing molecules that can selectively inhibit @entity8207 is reviewed. CONCLUSION: @entity8207 has the potential to be a target for anti-inflammatory therapy, devoid of adverse GIT and cardiac effects and warrants further investigation.

title: XXXX synthase inhibition as a therapeutic target.

entities_list: @entity13586 :: ('MESH:C116926', 'Chemical') :: ['rofecoxib']

entities_list: @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A(2)']

entities_list: @entity1421 :: ('MESH:D015232', 'Chemical') :: ['PGE(2)', 'prostaglandin E(2)']

entities_list: @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostaglandin I(2)']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1421 :: (MESH:D015232,Chemical) :: ['Prostaglandin E(2)']


abstract: BACKGROUND: @entity15476 ( @entity40989 , AP), an active component of many medicinal Chinese herbs, exhibits anticancer properties in vitro and in vivo. This study aims to investigate the genotoxic, cytostatic, and cytotoxic effects of AP and time course changes in the levels of anti- and pro-apoptotic proteins involved in the DNA damage response in HepG2 cells. METHODS: The genotoxic potential of AP was determined by sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) analysis. The levels of cytostaticity and @entity137 were evaluated by the proliferation rate and mitotic indices, respectively. @entity98 was used to study @entity137 , while the induction of apoptosis and the expression of apoptosis-related proteins were determined by ELISA. RESULTS: At concentrations greater than 10  M, AP decreased cell survival in a dose- (48 h: 10 vs. 20    , P   <   0.001 and 20 vs. 50    , P   =   0.005; 72 h: 10 vs. 20    , P   <   0.001 and 20 vs. 50    , P   =   0.001) and time-dependent manner (20    : 24 vs. 48 h, P   <   0.001 and 48 vs. 72 h, P   =   0.003; 50    : 24 vs. 48 h, P   <   0.001 and 48 vs. 72 h, P   <   0.001; 100    : 24 vs. 48 h, P   <   0.001 and 48 vs. 72 h, P   <   0.001). SCEs rates, cell proliferation, and mitotic divisions were also affected in a dose-dependent manner (P   <   0.001). There was no change in the frequency of aberrant cells (1      -P: P   =   0.554; 10  M AP: P   =   0.337; 20     AP: P   =   0.239). @entity588 levels were reduced 3 h after AP administration (P   =   0.003) and remained reduced throughout the 48 h observation period (6 h, P   =   0.044; 12 h, P   =   0.001; 24 h, P   =   0.042; 48 h, P   =   0.012). @entity589 and soluble Fas exhibited a transient upregulation 24 h after AP treatment. The @entity589 / @entity588 ratio was also increased at 12 h and remained increased throughout the 48 h observation period. CONCLUSION: AP exhibited dose-dependent genotoxic potential in HepG2 cells. The protein levels of sFas, @entity588 , and @entity589 were affected by AP to promote cell survival and cell death, respectively.

title: Time course changes of anti- and pro-apoptotic proteins in XXXX -induced genotoxicity.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity40989 :: ('CHEBI:18388', 'Chemical') :: ["4',5,7-trihydroxyflavone"]

answer: @entity15476 :: (MESH:D047310,Chemical) :: ['apigenin']


abstract: UNASSIGNED: Polyadenylation is a critical 3'-end processing step during maturation of pre-mRNAs, and the length of the poly(A) tail affects mRNA stability, nuclear export and translation efficiency. The @entity958 genome encodes three canonical nuclear poly(A) polymerase (PAPS) isoforms fulfilling specialized functions, as reflected by their different mutant phenotypes. While @entity36551 affects several processes, such as the immune response, organ growth and male gametophyte development, the roles of @entity36552 and @entity36553 are largely unknown. Here we demonstrate that @entity36552 and @entity36553 promote flowering in a partially redundant manner. The enzymes act antagonistically to @entity36551 , which delays the transition to flowering. The opposite flowering-time phenotypes in @entity36551 and @entity36552 @entity36553 mutants are at least partly due to decreased or increased FLC activity, respectively. In contrast to @entity36552 @entity36553 mutants, plants with increased @entity36553 activity flower earlier than the wild-type, concomitant with reduced FLC expression. Double mutant analyses suggest that @entity36552 and @entity36553 act independently of the autonomous pathway components FCA, FY and @entity36554 . The direct polyadenylation targets of the three PAPS isoforms that mediate their effects on flowering time do not include FLC sense mRNA and remain to be identified. Thus, our results uncover a role for canonical PAPS isoforms in flowering-time control, raising the possibility that modulating the balance of the isoform activities could be used to fine tune the transition to flowering.

title: Antagonistic control of flowering time by functionally specialized poly(A) polymerases in XXXX .

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis thaliana']


abstract: PURPOSE: To report the use of a technique (PETTICOAT: provisional extension to induce complete attachment) to obliterate sustained abdominal false lumen flow and pressurization despite successful stent-graft sealing of the thoracic entry tear in @entity1 with complicated type B @entity1580 . METHODS: Of 100 initial @entity1 subjected to stent-graft repair for complex type B @entity1580 with thoracoabdominal extension, 12 @entity1 (10 @entity1 ; mean age 58.7 years, range 44-76) demonstrated distal true lumen collapse and a perfused abdominal false lumen despite successful sealing of the proximal tears. As an adjunctive or staged procedure, a scaffolding stent was placed for distal extension of the previously implanted stent-graft. In each case, a @entity50 aortic stent, Fortress stent, or a Z-stent system was customized with maximum 2-mm oversizing versus the original stent-graft diameter. Magnetic resonance or computed tomographic angiography was performed at discharge, at 3 months, and then annually to determine false channel @entity715 , true and false lumen dimensions, and re-entry flow. RESULTS: Delivery was successful in all cases (100%). The compressed distal true lumen (mean 4+/-3 mm) was reconstructed to a mean width of 21+/-3 mm, and malperfusion was abolished without any obstruction of the abdominal side branches. At up to 1-year follow-up, there were no signs of expansion or distal progression of the scaffolded dissected aorta. All @entity1 with complete thoracic @entity715 showed evidence of improved aortic remodeling; 1 @entity1 with no false lumen @entity715 died at 11 months from thoracoabdominal aortic rupture. CONCLUSION: The PETTICOAT technique may offer a safe and promising adjunctive endovascular maneuver for @entity1 with distal malapposition of the dissecting membrane and false lumen flow. The technique can both abolish distal true lumen collapse and enhance the remodeling process of the entire dissected aorta.

title: Provisional extension to induce complete attachment after stent-graft placement in type B XXXX : the PETTICOAT concept.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

answer: @entity1580 :: (MESH:C562834,Disease) :: ['aortic dissection']


abstract: UNASSIGNED: Stem-cell based gene therapy is a promising novel therapeutic approach for inoperable @entity3 including @entity11 . Previously, we demonstrated the therapeutic potential of @entity1 adipose tissue-derived mesenchymal stem cells (hAT-MSC) genetically engineered to express a secreted form of @entity5 @entity39 factor-related apoptosis-inducing ligand (sTRAIL) against @entity11 . However, safety concerns should be comprehensively investigated before clinical applications of hAT-MSC.sTRAIL. At first, we injected stereotactically Low (1.2 * 105 cells/18 ul), Medium (2.4 * 105/18 ul), or High dose (3.6 * 105/18 ul) of hAT-MSC.sTRAIL into the brainstems of immune-deficient @entity19 reflecting the plan of the future clinical trial. Local @entity137 , systemic @entity137 , secondary @entity5 formation, and bio-distribution of hAT-MSC.sTRAIL were investigated. Next, presence of hAT-MSC.sTRAIL was confirmed in brain and major organs at 4, 9 and 14 weeks in @entity11 -bearing @entity19 . In the 15-week subchronic @entity137 test, no serious adverse events in terms of body weight, food consumption, clinical symptom, urinalysis, hematology, clinical chemistry, organ weight, and histopathology were observed. In the 26-week tumorigenicity test, hAT-MSC.sTRAIL made no detectable @entity5 , while positive control U-87MG cells made huge @entity5 in the brainstem. No remaining hAT-MSC.sTRAIL was observed in any organs examined including the brainstem at 15 or 26 weeks. In @entity11 -bearing @entity19 , injected hAT-MSC.sTRAIL was observed but gradually decreased over time in the brain. The mRNA of @entity1 specific GAPDH and @entity2205 was not detected in all major organs. These results indicate that the hAT-MSC.sTRAIL could be applicable to the future clinical trials in terms of bio-safety.

title: Preclinical biosafety evaluation of genetically modified @entity1 adipose tissue-derived mesenchymal stem cells for clinical applications to XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['brainstem glioma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive tumors']

answer: @entity11 :: (MESH:D005910,Disease) :: ['brainstem glioma']


abstract: BACKGROUND: The aim of our study was to compare colon capsule endoscopy (CCE) with standard colonoscopy (SC) in the assessment of @entity3137 activity and localization of inflammatory colonic mucosa in @entity1 with known @entity31 ( @entity31 ). METHODS: Thirteen symptomatic @entity1 (8 males, 5 females, mean age 38.5    12.0 years) with known @entity31 (mean duration of @entity1960 : 9.7    8.1 years) and indication for endoscopy due to suspected disease activity were included. All @entity1 underwent CCE (first generation capsule, Given Imaging Ltd., Yokneam, Israel) on day 1 followed by SC on day 2 in a single center non-randomized, non-placebo-controlled diagnostic study (NCT00837304). SC and CCE were video recorded, and analysis was independently performed by 6 experienced endoscopists. The modified Rachmilewitz score was calculated, and Wilcoxon signed-rank test was used for analysis. Difference in recognition of disease activity by the endoscopists was assessed by application of the Kruskal-Wallis test. RESULTS: Assessment of disease activity revealed a significantly higher Rachmilewitz score of 7.3    2.9 in the SC group compared to 4.8    3.4 in the CCE group. Significantly, more detection of vessel vulnerability, granulated mucosa and @entity16 was seen by SC. Disease extension was underestimated by CCE compared to SC. Disease activity assessment by means of SC or CCE did not differ statistically between the investigators (p = 0.26 and p = 0.1, respectively). After CCE, the capsule egestion rate was 77 %. The overall acceptance of both procedures was similar. CONCLUSION: Considering the significantly different assessment of disease activity and significantly more appropriate assignment of the horizontal spread of inflammation by SC versus CCE, we recommend the preferential use of SC in the assessment of inflammation in @entity31 @entity1 .

title: Colon capsule endoscopy versus standard colonoscopy in assessing disease activity of XXXX : a prospective trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['mucosal damage']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal disease']

answer: @entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']


abstract: AIMS AND OBJECTIVES: Maintaining adequate ratios of @entity1372 -to- @entity972 requires @entity712 @entity1 to be adherent to recommended dietary guidelines. A potential deterrent to adherence is poor cognitive functioning. The aims of this study were to (1) estimate dietary @entity1372 and @entity972 intake and @entity1372 -to- @entity972 ratios and (2) examine the associations between cognitive functioning and @entity1372 -to- @entity972 ratios. BACKGROUND: @entity73 may impact levels of adherence and subsequently @entity1372 -to- @entity972 ratios; however, little is known about the relationship of cognitive functioning, adherence to dietary restrictions and @entity1372 -to- @entity972 ratios. DESIGN: This study used a descriptive correlational design. METHODS: Face-to-face interviews were conducted with @entity712 @entity1 with preserved or reduced left ventricular ejection fraction. Standard cognitive measures were used and included neuropsychological tests of global cognition, immediate and delayed recall, and executive function. Further, @entity1 were instructed to complete a three-day food diary as an indirect measure of @entity1372 -to- @entity972 intake. RESULTS: Ninety-one Korean @entity1 with @entity712 participated in this study (age 57  years, @entity1 33%, education 10  years). A major underlying cause for @entity712 was @entity384 (40%), followed by ischaemic cause (24%); the mean @entity712 duration was 37  months. Average @entity1372 intake was 3982  mg/day, with @entity1 consuming a significantly higher amount than @entity1 (4207 vs. 3523  mg). @entity972 intake was 2583  mg/day, with both @entity1 and @entity1 consuming similarly insufficient amounts. @entity1372 -to- @entity972 ratio was 1  60, with @entity1 having a significantly elevated ratio compared with @entity1 (1  68 vs. 1  44). Cognitive function by @entity1372 -to- @entity972 quartile groups showed nonlinear associations. CONCLUSION: @entity1 in the study consumed excessive @entity1372 and insufficient @entity972 ; correspondingly, elevated @entity1372 -to- @entity972 ratios showed significant associations with cognitive function (memory). RELEVANCE TO CLINICAL PRACTICE: Dietary guidelines tailored to levels of cognitive function as well as Korean dining culture may be important in ensuring @entity1372 -to- @entity972 balance in these @entity712 @entity1 .

title: An examination of the association of cognitive functioning, adherence to @entity1372 restriction and Na/K ratios in Korean XXXX @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Participants', 'men']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['Cognitive impairment']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity1372 :: ('MESH:D012964', 'Chemical') :: ['Sodium', 'sodium']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium', 'Potassium']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: OBJECTIVE: Mindfulness has been defined as being intentionally aware of internal and external experiences that occur at the present moment, without judgment. Techniques that develop mindfulness, such as meditation, have positive effects on reducing @entity22 , a @entity25 that is common both during and after menopause. Our aim was to establish whether postmenopausal @entity1 with @entity22 are less mindful than postmenopausal @entity1 without @entity25 . METHODS: Postmenopausal @entity1 aged 50 to 65 years who did not use hormone therapy were recruited for the study. The sample included 14 @entity1 with @entity22 and 12 @entity1 without @entity22 or any other @entity25 . The groups were comparable in age, schooling, and @entity148 level. To assess mindfulness, we used the validated Mindful Attention Awareness Scale and the attentiveness domain of the Positive and Negative Affect Schedule-Expanded Form. RESULTS: @entity1 with @entity22 were less mindful than healthy @entity1 . The level of mindfulness was able to discriminate the group with @entity22 from the healthy group, with 71.4% accuracy. CONCLUSIONS: Postmenopausal @entity1 with @entity22 are less mindful than @entity1 without @entity22 . Mindfulness-based interventions, such as meditation, may be beneficial for postmenopausal @entity22 .

title: Is mindfulness associated with XXXX after menopause?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Participants']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'sleep disorder']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity22 :: (MESH:D007319,Disease) :: ['insomnia']


abstract: Chronic @entity2885 is associated with vesicoureteric reflux in infancy. @entity2402 during childhood in 50% of cases. It is more commonly detected in @entity1 (49%) and @entity1 (26%) with @entity281 than in adults (4.4%). Severe reflux may persist in adults and is usually (94%) associated with @entity2318 . @entity1 with @entity454 due to @entity2885 are much younger than @entity1 with @entity454 due to other causes. The incidence of reflux according to sex is equal in infancy, but after infancy both @entity2318 and reflux are far more common in females. Infection is the likely cause of progressive @entity2318 in females. @entity101 is associated with chronic @entity2885 . @entity644 is the worst prognostic feature in @entity1 with @entity8 and @entity2318 . Intrarenal reflux determines the site of @entity2318 . The role of surgical correction of vesicoureteric reflux remains uncertain, but meticulous control of @entity281 appears to prevent progressive @entity2318 .

title: XXXX and chronic @entity2885 : a review.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'infants']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['Proteinuria']

entities_list: @entity2402 :: ('MESH:D010015', 'Disease') :: ['Reflux disappears']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['reflux nephropathy']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity2318 :: ('MESH:D002921', 'Disease') :: ['pyelonephritic scarring', 'scarring']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis', 'atrophic pyelonephritis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal failure']

answer: @entity8 :: (MESH:D007674,Disease) :: ['Reflux nephropathy']


abstract: Twenty-three consecutive @entity1 with duodenal @entity1066 complicated by @entity2203 who came under the care of one surgeon were treated by highly selective vagotomy (HSV) combined with digital dilatation of the @entity850 through a gastrotomy. No form of @entity5173 procedure was used. Thus the antral "mill" and the pyloric sphineter were left intact. Since the @entity850 is usually distal to the pylorus rather than truly pyloric such dilatation does not damage the pyloric ring, although it may on occasion lead to perforation of the first part of the duodenum. The subsequent progress of these @entity1 was compared with that of a similar, consecutive series of 23 @entity1 with @entity2203 who were treated by truncal vagotomy with a @entity5173 procedure by other surgeons on the same surgical unit. @entity1 were followed up for between four months and five years. The clinical assessment was carried out in "blind" fashion at a special gastric follow-up clinic. No evidence of recurrent @entity1066 was found in either group of @entity1 . Two @entity1 from each group subsequently came to reoperation for the relief of @entity7623 . Twenty-two of the 23 @entity1 (96%) who had undergone HSV plus dilatation eventually achieved a good-to-excellent clinical result (Visick grades 1+2), wheras only 17 of the 23 @entity1 (74%) who had undergone truncal vagotomy with @entity5173 achieved such a result. The main clinical difference between the two groups was that side effects such as @entity294 and @entity490 or discomfort were more common after vagotomy with @entity5173 than after HSV. These results bear witness to the remarkable propulsive powers of the gastric antrum after HSV, which were evidently sufficient to overcome any tendency to @entity850 in more than 90% of @entity1 . The 9% incidence of failure due to @entity850 could perhaps be avoided if a small duodenoplasty were performed instead of simple digital dilatation. The results support the hypothesis that damage to the antral mill and pyloric sphincter can be avoided in the course of operations for "pyloric" @entity850 secondary to duodenal @entity1066 . Avoidance of the @entity5173 procedure is of benefit to the @entity1 , just as it is in @entity1 who have duodenal @entity1066 without @entity850 .

title: Highly selective vagotomy plus dilatation of the @entity850 compared with truncal vagotomy and @entity5173 in the treatment of @entity2203 secondary to duodenal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity2203 :: ('MESH:D011707', 'Disease') :: ['pyloric stenosis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity7623 :: ('MESH:D018589', 'Disease') :: ['gastric stasis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['re-stenosis', 'stenosis']

answer: @entity1066 :: (MESH:D014456,Disease) :: ['ulceration']


abstract: OBJECTIVES: This study compared a behavioral @entity353 program (BWL) with a stress management-based program, Emotional Brain Training (EBT), on @entity353 , blood pressure, @entity308 , perceived stress, diet, and physical activity. METHODS: Subjects with a body mass index (BMI) of >28 and  <45  kg/m(2) were recruited in Lexington, Kentucky in January 2014 and randomized to BWL or EBT for a 20-week intervention. Of those recruited, 49 @entity1 were randomized to EBT or BWL. Randomization and allocation to group were performed using SPSS software. Weight, blood pressure, @entity308 , perceived stress, dietary intake, and physical activity were measured at baseline, 10  week, and 20  week. Linear models for change over time were fit to calculate 95% confidence intervals of intervention effects. RESULTS: BWL produced greater changes in BMI than EBT at both 10 (P  =  0.02) and 20  wk (P  =  0.03). At 10  wk, both EBT and BWL improved BMI, systolic blood pressure, @entity308 and perceived stress (P  <  0.05). BWL also improved diastolic blood pressure (P  =  0.005). At 20  wk, EBT maintained improvements in BMI, systolic blood pressure, @entity308 , and perceived stress while BWL maintained improvements only in BMI and @entity308 (P  <  0.05). CONCLUSIONS: BWL produced greater @entity353 than EBT; however, EBT produced sustained improvements in stress, @entity308 , and systolic blood pressure. A combination of the two approaches should be explored.

title: A comparison of a behavioral XXXX program to a stress management program: A pilot randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

answer: @entity353 :: (MESH:D015431,Disease) :: ['weight loss']


abstract: The effects of @entity1068 (0.4, 0.8, 1.6, and 2.4 g/kg p.o.) on behavior of @entity146 , timid, and sociable male @entity19 treated with the drug on paired interactions with non- @entity146 males given water were investigated. Under control interactions, @entity146 @entity19 attacked their partners, timid @entity19 showed defensive-escape activities though their partners were completely non- @entity146 , and sociable @entity19 intensively investigated their partners. A low dose of @entity1068 (0.4 g/kg) increased while higher doses (0.8 to 2.4 g/kg) reduced @entity146 activities in @entity146 @entity19 . @entity1068 (0.8 g/kg) also evoked @entity146 in non- @entity146 timid @entity19 but no dose of @entity1068 stimulated aggression in non- @entity146 sociable @entity19 . @entity1068 altered timid defensive-escape activities only in the highest dose of 2.4 g/kg: this dose increased defences and escapes in @entity146 males while it reduced defensive upright postures in timid @entity19 . However, 2.4 g/kg of @entity1068 reduced also another upright movement (exploratory rearing) in timid @entity19 . Sociable activities were not increased by any dose of @entity1068 tested. By contrast, 0.4 g/kg of @entity1068 reduced sniffing and following partners in sociable @entity19 . Thus, @entity1068 exhibit relatively strong aggression-stimulating effects in aversively disposed subjects while the drug was not able to supress timid defensive escape behavior and to stimulate active non- @entity146 contacts between strange male @entity19 .

title: Effect of XXXX on aggression and timidity in @entity19 .

entities_list: @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior', 'aggressive']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']