abstract: INTRODUCTION: Stent-assisted coiling of @entity438 is a viable and efficient treatment alternative to surgical clipping but requires prolonged antiplatelet therapy. Some @entity1 can be nonresponsive to @entity117 and/or @entity1397 . This is the first study analyzing the implications of this assessment using the "whole blood aggregometry (WBA) by impedance" technique. METHODS: The Southwestern Tertiary Aneurysm Registry (STAR) was reviewed between 2002 and 2012 for @entity1 with @entity439 treated with stent-assisted coiling. The study population was divided into @entity1 who were tested preoperatively for platelet responsiveness to @entity117 and @entity1397 ("tested" @entity1 ) and those who were not ("nontested" @entity1 ). Where necessary, a majority of tested @entity1 received additional doses of antiplatelet drugs to achieve adequate platelet inhibition. End points included the incidence of antiaggregant nonresponsiveness, the rates of @entity548 , and the rates of permanent morbidity and mortality. RESULTS: A total of 266 @entity1 fulfilled our selection criteria. There were 114 nontested @entity1 who underwent 121 procedures, and 152 tested @entity1 who underwent 171 procedures. The 2 groups did not vary significantly in @entity1 age, sex, and @entity439 location. @entity117 nonresponsiveness was detected in 3 @entity1 (1.75%) and @entity1397 nonresponsiveness was detected in 21 @entity1 (12.3%). Nontested @entity1 had an 11.5% rate of @entity715 with a 4.23% permanent morbidity or mortality rate vs 2.3% and 0.58% in tested @entity1 (P = .001). The incidence of @entity548 complications was similar between the 2 groups. CONCLUSION: Preoperative platelet inhibition testing using WBA can be useful to assess and correct antiaggregant nonresponsiveness, and may reduce postoperative mortality and permanent morbidity.

title: 304   The Contribution of Whole Platelet Aggregometry to the Endovascular Management of XXXX : An Institutional Experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic', 'thrombotic and hemorrhagic complications']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['Aspirin', 'aspirin']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'unruptured aneurysms']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic complications']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

answer: @entity439 :: (MESH:D000783,Disease) :: ['Unruptured Aneurysms']


abstract: We have re-examined histopathological specimens of @entity1313 extirpated at China Medical University from May, 1990 to June, 1992. During the last 2 years, about 400 cases of @entity1313 were operated and 349 cases were histopathologically diagnosed and classified by one of the authors (T. I). The most common @entity5 was @entity1653 , 97 cases, followed by @entity11 , 87 case and @entity808 , 71 cases. The sex and age distributions of these three @entity5 types were compared to those of Kyushu University Hospital, Japan. The most striking difference was age of @entity1653 and @entity808 @entity1 , and Chinese @entity1 were 10 years younger than Japanese @entity1 . The incidence of 30th age group of @entity1653 was 25% in China and 10% in Japan. Thirty percent of @entity808 @entity1 were operated at 30th and 40th age in China and Japan, respectively. The sex and ages of @entity816 @entity1 were almost the same frequencies in China and Japan. Among 22 cases of @entity5 , 11 cases of @entity5 in cerebello-pontine cistern was included. @entity1779 , although rarely encountered in Japan, was 2 cases in China.

title: [Comparative study of XXXX treated at China Medical University, China and Kyushu University, Japan].

entities_list: @entity808 :: ('MESH:D009442', 'Disease') :: ['neurinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'epidermoid tumor', 'congenital tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['Cerebral tuberculoma']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['brain tumors']


abstract: PURPOSE: To determine the effects of @entity2306 , a @entity4357 3-kinase inhibitor, on suppressing experimental @entity2479 in an animal model of @entity63 . METHODS: The effect of @entity2306 on the survival of RF/6A cells stimulated by @entity1611 ( @entity1611 ) was investigated colorimetrically. The inhibitory activity of @entity2306 on the migration of cells stimulated with @entity1611 was measured by cell counting. C57BL/6 @entity19 at postnatal day (P) 7 were exposed to 75 +/- 2% @entity26 for 5 days (P7-P11) and then returned to room air for 5 days ( @entity14800 - @entity14802 ) to induce @entity2479 . Beginning on @entity14800 , @entity19 received daily intraperitoneal injections of @entity2306 or @entity3733 and @entity1391 -buffered saline (control) through @entity14802 . @entity2479 was examined by @entity859 diphosphatase staining after 5 days in room air and was quantitated histologically by counting the neovascular endothelial cell nuclei anterior to the inner limiting membrane. RESULTS: @entity2306 significantly inhibited @entity1611 -induced survival and migration. @entity2306 -treated and control animals demonstrated no perfusion regions in the posterior retina. Retinas from control @entity19 at @entity14802 contained neovascular tufts at the junction between the perfused and nonperfused retina. The tufts contained numerous neovascular nuclei. Retinas from @entity19 treated with @entity2306 demonstrated a significant reduction in neovascular cell nuclei compared with control @entity19 . CONCLUSIONS: @entity2306 significantly inhibits @entity2479 in a @entity19 model of @entity2479 .

title: Effects of the XXXX 3-kinase inhibitor in a @entity19 model of @entity2479 .

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic retinopathy']

entities_list: @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinal neovascularization', 'Retinal neovascularization']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity4357 :: ('MESH:D010716', 'Chemical') :: ['phosphatidylinositol']

answer: @entity4357 :: (MESH:D010716,Chemical) :: ['phosphatidylinositol']


abstract: BACKGROUND: Previously, advanced endometrial maturation on the day of oocyte retrieval in @entity4396 antagonist and -agonist IVF cycles was observed. In these cycles, endometrial advancement exceeding 3 days between the histological dating and the cycle day never resulted in an ongoing clinical pregnancy. In this study, the gene expression of @entity1 endometrium on the day of oocyte retrieval in @entity4396 antagonist/rec-FSH cycles was analyzed, in correlation with the morphological dating. METHODS: Biopsies were taken on the day of oocyte retrieval in 47 @entity1 with 1 or 2 embryos replaced on Day 3 in the same cycle. Endometrial dating was performed according to Noyes' criteria. Biopsies from 11 @entity1 were analyzed for gene expression with the Affymetrix HG U133 Plus 2 microarray. Data analysis, clustering and pathway analysis were performed with GCOS, GeneSpring 7.3 and Ingenuity, respectively. RESULTS: According to Noyes' criteria, all endometria taken on the day of oocyte retrieval showed an advanced maturation, ranging from +d2 to +d4. The @entity1 with a subsequent clinical pregnancy all showed a histological dating corresponding to +d2 or +d3. When comparing endometria +d2-3 to +d4, the microarray results showed a differential expression of 2550 probe sets. Significantly up-regulated genes were @entity40482 , @entity16389 , @entity13050 and @entity5605 . Down-regulated genes of interest were @entity12867 , @entity35770 and @entity8087 . Principal component analysis and hierarchical clustering demonstrated two distinct clusters. CONCLUSIONS: In stimulated cycles, endometrial gene expression on the day of oocyte retrieval discriminates between @entity1 with and without histologically advanced endometrial maturation exceeding 3 days and supports histological dating results by Noyes' criteria.

title: In XXXX antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients']

answer: @entity4396 :: (2796,Gene) :: ['GnRH']


abstract: UNASSIGNED: @entity398 (OT) and vasopressin (AVP) regulate various social behaviors via activation of the OT receptor ( @entity25809 ) and the AVP V1a receptor ( @entity36496 ) in the brain. Social behavior often differs across development and between the sexes, yet our understanding of age and sex differences in brain @entity25809 and @entity36496 binding remains incomplete. Here, we provide an extensive analysis of @entity25809 and @entity36496 binding density throughout the brain in juvenile and adult male and female @entity35 , with a focus on regions within the social decision-making network. @entity25809 and @entity36496 binding density were higher in juveniles than in adults in regions associated with reward and socio-spatial memory and higher in adults than in juveniles in key regions of the social decision-making network and in cortical regions. We discuss possible implications of these shifts in @entity25809 and @entity36496 binding density for the age-specific regulation of social behavior. Furthermore, sex differences in @entity25809 and @entity36496 binding density were less numerous than age differences. The direction of these sex differences was region-specific for @entity25809 but consistently higher in females than in males for @entity36496 . Finally, almost all sex differences in @entity25809 and @entity36496 binding density were already present in juveniles and occurred in regions with denser binding in adults compared to juveniles. Possible implications of these sex differences for the sex-specific regulation of behavior, as well potential underlying mechanisms, are discussed. Overall, these findings provide an important framework for testing age- and sex-specific roles of @entity25809 and @entity36496 in the regulation of social behavior.

title: Age and sex differences in XXXX and @entity36496 binding densities in the @entity35 brain: focus on the social decision-making network.

entities_list: @entity398 :: ('MESH:D010121', 'Chemical') :: ['Oxytocin']

answer: @entity398 :: (MESH:D010121,Chemical) :: ['oxytocin']


abstract: @entity160 -Producing @entity356 is associated with poor prognosis because of frequent liver and lymph node @entity3 . We present a case with @entity409 who survived for 5 years. A 69-year-old @entity1 with upper @entity490 was referred to our hospital. Gastrointestinal endoscopy revealed a @entity5 in the lower part of the stomach. Computed tomography revealed a @entity5 in the left lobe of the liver. Serum @entity160 levels were markedly increased. We performed distal gastrectomy after administering oral tegafur/ @entity11828 /oteracil @entity972 and administered hepatic intra-arterial @entity900 injection. @entity409 showed partial response on computed tomography. Despite left hepatic lobectomy, further metastases to the liver and mediastinal lymph nodes became difficult to control. After @entity2857 tosylate administration, stabilization of the disease was observed for 4 months. We conclude that hepatic intra-arterial chemotherapy and oral administration of @entity2857 may potentially improve the prognosis in such cases.

title: Five-year survival of @entity160 -producing @entity356 with XXXX : a case report.

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Borrmann II-like tumor']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['synchronous liver metastasis', 'Liver metastasis']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2857 :: ('MESH:C471405', 'Chemical') :: ['sorafenib', 'sorafenib tosylate']

entities_list: @entity160 :: ('174', 'Gene') :: ['alpha-fetoprotein', 'Alpha-fetoprotein']

entities_list: @entity11828 :: ('MESH:C104201', 'Chemical') :: ['gimeracil']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity409 :: (MESH:D008107,Disease) :: ['synchronous liver metastasis']


abstract: BACKGROUND: B-cells are prominent immune cells in @entity2520 . Tumour @entity39 factor superfamily (TNFSF) cytokines play roles in supporting B-cell function as well as bone re-modelling. The influence of smoking on factors that support B-cell function in @entity2521 remains unclear. AIM: To investigate plasma concentrations of @entity310 ( @entity310 ), soluble receptor activator of nuclear-factor Kappa-B ligand (sRANKL/ @entity5298 ), a proliferation-inducing ligand (APRIL/ @entity32969 ), @entity8410 ( @entity8410 / @entity8410 ) and @entity2159 ( @entity2159 / @entity2159 ) in smokers and non-smokers with and without @entity7278 MATERIALS _ METHODS: Plasma concentrations of TNFSF and @entity2159 were evaluated in 200 systemically healthy subjects divided into four groups: non-smokers with @entity2521 (n  =  101), smokers with @entity2521 (n  =  55), healthy non-smokers (n  =  27) and healthy smokers (n  =  17). RESULTS: @entity2521 @entity1 had significantly higher plasma sRANKL, @entity310 , APRIL and @entity8410 and lower @entity2159 than healthy subjects (p  <  0.01). @entity310 and sRANKL were significantly greater in smokers with @entity2521 (p  =  0.011, p  =  0.001) and @entity2159 concentrations significantly lower (p  =  0.001), whereas APRIL or @entity8410 were little changed. Plasma APRIL, @entity8410 , sRANKL and @entity310 correlated with probing depth and clinical attachment loss. CONCLUSION: TNFSF cytokines correlate with @entity2520 severity. However, only @entity310 , sRANKL and @entity2159 levels were altered by cigarette smoking. APRIL and @entity8410 appear as good indicators of disease severity.

title: Comparison of circulating tumour @entity39 factor superfamily cytokines in @entity2521 XXXX undergoing supportive therapy: a case-controlled cross-sectional study comparing smokers and non-smokers in health and disease.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontitis disease', 'established periodontitis lesions']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity8410 :: ('10673', 'Gene') :: ['B-cell activating factor', 'BAFF', 'TNFSF13B']

entities_list: @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['Periodontitis', 'periodontitis']

entities_list: @entity2159 :: ('4982', 'Gene') :: ['TNFRSF11B', 'Osteoprotegerin', 'OPG']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES: Presentation of a series of 18 @entity1 who underwent surgery of @entity1369 -producing @entity652 ( @entity1368 ) over the last 10 years. Assessment of the most significant clinical and pathological aspects from a surgical point of view. METHODS: Retrospective study evaluating a broad range of features: clinical, analytical, hormonal, imaging, types of anaesthesia, approaches, technique used, intra and post-operative morbidity and mortality, evolution and pathoanatomical diagnosis. RESULTS: The most frequent clinical data of primary @entity1368 were: 94.4% volume-dependent @entity20166 , 50% @entity10 and @entity1296 , 27.8% epistasis and/or episodes of angor or acute @entity583 , and 22.2% @entity712 . The biochemical study and hormonal testing evidenced: @entity1371 in 88.9%, @entity5838 66.7% and @entity3489 in 61.1%. Mean @entity1369 levels were 517.5 pg/mL, and urinary levels 85.9 mcg/day. Resting plasma @entity916 activity (PRA) < 0.2 ng/mL/h in 77.8% cases and positive @entity1369 stimulation test in 61.1%: @entity3371 test positive. Imaging diagnosis was based in CAT which was conclusive in 88.9% and ultrasound which was diagnostic in 27.8% cases. The surgical approach was: lumbotomy (over the 11th or 12th rib) in 14 @entity1 and transpleurodiaphragmatic in all remaining @entity1 . The @entity3816 reported were placement of endothoracic tube due to @entity4499 in two occasions. Duration of the procedure (mean 136.1 min) and post-operative hospitalization (mean 7.76 days), as well as post-surgery follow-up for up to 96 months were also studied. At final time point there was 66.7 asymptomatic @entity1 , 33.3% cases of @entity20166 , and no deaths. CONCLUSIONS: @entity1368 due to @entity652 is an uncommon reason for @entity20166 , but in most cases can be cured with surgery. Biochemical and hormonal testing is determinant to research a diagnosis. Ultrasound and CAT are essential for imaging diagnosis, and occasionally NMR can be of help. Lumbotomy is considered the choice approach for these small @entity5 as it is a familial technique for urologists with a low complications rate.

title: [The XXXX . The clinical and surgical aspects of 18 cases of @entity652 ].

entities_list: @entity4499 :: ('MESH:D007049', 'Disease') :: ['iatrogenic pneumothorax']

entities_list: @entity5838 :: ('MESH:D000471', 'Disease') :: ['metabolic alkalosis']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours']

entities_list: @entity3371 :: ('CHEBI:3380', 'Chemical') :: ['captopril']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adrenal adenoma']

entities_list: @entity1368 :: ('MESH:D006929', 'Disease') :: ['Primary hyperaldosteronism', 'hyperaldosteronism', "Conn's syndrome"]

entities_list: @entity1371 :: ('MESH:D007008', 'Disease') :: ['hypokalemia']

entities_list: @entity3489 :: ('MESH:D006955', 'Disease') :: ['hypernatremia']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['intraoperative complications']

answer: @entity1368 :: (MESH:D006929,Disease) :: ['Conn syndrome']


abstract: UNASSIGNED: @entity725 ( @entity725 ) is an @entity1781 and an irreversible blinding disease. The etiology of @entity726 is not known but numerous risk factors are associated with this disease including aging, @entity2790 (IOP), race, @entity1714 , family history and use of @entity230 . In @entity725 , the resistance to the @entity7462 drainage is increased leading to elevated IOP. Lowering the resistance and ultimately the IOP has been the only way to slow disease progression and prevent @entity1018 . The primary drainage pathway comprising of the trabecular meshwork (TM) is made up of relatively large porous beams surrounded by extracellular matrix (ECM). Its juxtacanalicular tissue (JCT) or the cribriform meshwork is made up of cells embedded in dense ECM. The JCT is considered to offer the major resistance to the @entity7462 outflow. This layer is adjacent to the endothelial cells forming Schlemm's canal, which provides approximately 10% of the outflow resistance. The ECM in the TM and the JCT undergoes continual remodeling to maintain normal resistance to @entity7462 outflow. It is believed that the TM is a major contributor of ECM proteins and evidence points towards increased ECM deposition in the outflow pathway in @entity725 . It is not clear how and from where the ECM components emerge to hinder the normal @entity7462 drainage. This review focuses on the involvement of the ECM in @entity2790 and @entity726 and the mechanisms by which various ocular @entity551 drugs, both current and emerging, target ECM production, remodeling, and deposition.

title: The exit strategy: Pharmacological modulation of extracellular matrix production and deposition for better XXXX drainage.

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['vision loss']

entities_list: @entity725 :: ('MESH:C562750', 'Disease') :: ['POAG', 'Primary open angle glaucoma']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor']

entities_list: @entity2790 :: ('MESH:D009798', 'Disease') :: ['ocular hypertension', 'elevated intraocular pressure']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

answer: @entity7462 :: (MESH:C562390,Disease) :: ['aqueous humor']


abstract: Ocular @entity15999 ( @entity15999 ) cells promote the generation of T regulators ( @entity15999 -induced Treg cells). Moreover, T cells exposed to @entity15999 acquire the capacity to suppress the activation of bystander T cells via @entity2533 . Membrane-bound @entity2533 on iris @entity15999 cells interacts with @entity2533 receptors on T cells, leading to the conversion of T cells to @entity405 (+) Treg cells via a cell contact-dependent mechanism. Conversely, soluble forms of @entity2533 produced by retinal @entity15999 cells can convert CD4(+) T cells into Treg cells in a manner that is independent of cell contact. In this study, we looked at the expression of immunoregulatory factors ( @entity2533 , thrombospondins, @entity1009 , @entity1193 , etc.) in @entity15999 cells as identified via an oligonucleotide microarray. Several thrombospondin-binding molecules were detected, and thus we focused subsequent analyses on thrombospondins. Via the conversion of latent @entity2533 to an active form that appears to be mediated by @entity3499 ( @entity3499 ), cultured iris @entity15999 and retinal @entity15999 cells induce a @entity15999 -induced Treg cell fate. After conversion, both @entity15999 and @entity15999 -induced Treg cells express @entity3499 . Regulatory T cell generation was amplified when the T cells also expressed @entity3499 . In addition, @entity15999 -induced Treg cells significantly suppressed activation of bystander T cells via @entity3499 . These results strongly suggest that the ability of @entity15999 and @entity15999 -induced Treg cells to suppress bystander T cells depends on their capacity to produce @entity3499 . Thus, intraocular @entity3499 produced by both ocular parenchymal cells and regulatory T cells is essential for immune regulation in the eye.

title: Role of XXXX in T cell response to ocular pigment epithelial cells.

entities_list: @entity15999 :: ('MESH:C565530', 'Disease') :: ['PE', 'ocular PE', 'pigment epithelium']

entities_list: @entity1193 :: ('3557', 'Gene') :: ['IL-1 receptor antagonist']

answer: @entity3499 :: (7057,Gene) :: ['thrombospondin-1']


abstract: BACKGROUND AND STUDY AIM: The aim of this study was to elucidate the risk factors for local recurrence after endoscopic mucosal resection (EMR) treatment for superficial @entity418 (SEC). @entity1 AND METHODS: We performed a retrospective analysis of the clinical course of 62 @entity1 with 64 SECs that were treated by EMR between 1993 and 2004. Follow-up examinations by chromoscopy with @entity1496 solution and biopsy were performed 3 months, 6 months, 12 months, and then annually after EMR. Local recurrence was defined as a histologically confirmed finding of @entity5 cells at the site of the preceding EMR. The contributions of lesion-related and procedure-related factors to local recurrence were analyzed retrospectively. RESULTS: Local recurrence was detected in 14/64 SECs 3-36 months after EMR. Of the lesion-related factors we assessed, local recurrence was found to be more frequent in SECs with a larger diameter (P = 0.01), larger circumferential spread (P = 0.04), or deeper invasion (P = 0.04), although the last two factors failed to demonstrate statistical significance after correction for multiple testing. Piecemeal resection did not increase the risk of local recurrence (P = 0.11), but the need for adjunctive coagulation therapy was found to increase the risk of local recurrence (P = 0.06). CONCLUSIONS: Larger SECs are associated with a higher risk of local recurrence after EMR. In @entity1 with residual lesions, coagulation therapy does not seem to be adequate as additional endoscopic treatment.

title: Risk factors for local recurrence of superficial XXXX after treatment by endoscopic mucosal resection.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']


abstract: Serum samples were obtained from @entity1 with @entity2760 rheumatica (PMR: n = 10) or @entity226 ( @entity226 ; n = 7), or both. Samples were taken either before treatment or within one week of starting @entity617 . Immune complexes (IC) were concentrated by @entity968 ( @entity970 ) precipitation then purified with either IgG anti- @entity6300 -Sepharose or IgG anti-C3c-Sepharose. Complex components were separated by @entity214 ( @entity214 ) gradient @entity2975 gel electrophoresis then transferred to nitrocellulose by Western blotting. Identification of proteins was carried out using specific antisera. All the IC contained IgM (mu chain), some contained IgA ( @entity7722 (gamma chain). @entity34473 , @entity6300 , C3, C4, and @entity1851 ( @entity1851 ), where tested, were found in most but not all IC. The occurrence of properdin, factor @entity7819 macroglobulin ( @entity7819 M), factor H (beta 1H), C1 esterase inhibitor, and C4 binding protein was also investigated. Immune complexes in PMR and @entity226 differed from those previously characterized in @entity309 ( @entity309 )1 purified by anti- @entity6300 -Sepharose which contained immunoglobulins and @entity6300 only. No properdin or factor B were detected in @entity309 IC purified with either anti- @entity6300 -Sepharose or anti-C3c-Sepharose.

title: Isolation and analysis of immune complexes from sera of @entity1 with @entity2760 rheumatica and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity7722 :: ('2217', 'Gene') :: ['alpha chain), and IgG']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity226 :: ('MESH:D013700', 'Disease') :: ['giant cell arteritis', 'GCA']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity2760 :: ('MESH:D011111', 'Disease') :: ['polymyalgia']

entities_list: @entity214 :: ('CHEBI:8984', 'Chemical') :: ['sodium dodecyl sulphate', 'SDS']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

entities_list: @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C reactive protein', 'CRP']

answer: @entity226 :: (MESH:D013700,Disease) :: ['giant cell arteritis']


abstract: AIM: To investigate factors affecting refractive outcome following LASIK for @entity1714 . METHOD: Six hundred and seventy-four consecutive uncomplicated myopic LASIK surgeries, performed by a single surgeon, either using the Technolas 217 planoscan (n=372) or the NIDEK EC 5000 (n=302), were evaluated. Stratified random sampling was used to match the groups for @entity2516 , @entity1 age, and gender. The final analysis included 302 @entity1 from each treatment group. Conditions were identical for both surgeries, and pre-operative @entity2516 were between -1.00 and -14.00 DS and <-1.50 DC. Refractive success was defined as -0.50 to +0.50 DS of the targeted refraction measured 3 months after surgery. A stepwise logistical regression analysis was used to determine variables associated with refractive failure. RESULTS: A successful refractive outcome was achieved in 78% (235/302) of surgeries using the Technolas laser and in 88% (266/302) using the NIDEK laser. Predictor variables for not achieving refractive success were pre-operative @entity2516 .00 DS, age more than 40 years, and surgery performed with the Technolas laser. CONCLUSION: Both the Technolas 217 and the NIDEK EC-5000 excimer lasers achieve a successful refractive outcome in the majority of cases. However, @entity1 and surgical factors can influence refractive outcome.

title: Variables affecting refractive outcome following LASIK for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error', 'refractive error of above -5', 'refractive errors']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['myopia']


abstract: A 52-year-old @entity1 had @entity417 unresponsive to @entity2764 . @entity3052 developed, and he died four months after diagnosis. At autopsy he had @entity10706 with involvement of bone marrow, liver, spleen, adrenals, kidneys, and thyroid. Chromosomal analysis revealed absence of both diploid and @entity12297 chromosomes. A mode of 45 chromosomes and @entity2007 were present. This is similar to the only other case with chromosomal studies. Of the 15 acceptable documented cases, eight were @entity1 and seven were @entity1 . Their age varied from 28 to 76 (mean, 55) years. Only two were less than 40 years of age. Most had @entity3043 , and all were dead within six months of diagnosis.

title: Acute XXXX . Description of a case initially seen as preleukemia syndrome.

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity2764 :: ('MESH:D011736', 'Chemical') :: ['pyridoxine hydrochloride']

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['aregenerative anemia']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['Acute leukemia']

entities_list: @entity10706 :: ('MESH:D007947', 'Disease') :: ['acute megakaryocytic leukemia']

entities_list: @entity3043 :: ('MESH:D010198', 'Disease') :: ['pancytopenia']

answer: @entity10706 :: (MESH:D007947,Disease) :: ['megakaryocytic leukemia']


abstract: AIMS: Measure adherence and biofilm formation by cells of @entity3069 , @entity4594 and @entity7665 on common household plumbing materials namely stainless steel, glass, @entity219 -galvanized steel, @entity920 and @entity2634 ( @entity2634 ). METHODS AND RESULTS: Coupons in a CDC biofilm reactor were exposed to cell suspensions containing 10(5) NTM colony forming units (CFU) per ml and adherence measured for 6  h. Biofilm formation (increased numbers of adherent CFU) was measured weekly to 21  days in the absence of substantial numbers of suspended mycobacterial cells. Adherence was rapid and substantial with 2000-15  000  CFU  cm(-2) adhering within 1-6  h at room temperature. Biofilm numbers reached as high as 10(7)   CFU  cm(-2) . Biofilm-grown cells of Myco.  avium were more adherent compared with suspension-grown cells. CONCLUSIONS: @entity3069 , Myco.  intracellulare and Myco.  @entity7665 readily adhered and formed biofilms on all types of plumbing materials. Factors influencing adherence and biofilm formation were species, plumbing material and prior growth.

title: Adherence and biofilm formation of XXXX , @entity4594 and @entity7665 to household plumbing materials.

entities_list: @entity4594 :: ('1767', 'Species') :: ['Mycobacterium intracellulare']

entities_list: @entity2634 :: ('MESH:D011143', 'Chemical') :: ['polyvinyl chloride', 'PVC']

entities_list: @entity7665 :: ('36809', 'Species') :: ['abscessus', 'Mycobacterium abscessus']

entities_list: @entity3069 :: ('1764', 'Species') :: ['Mycobacterium avium']

answer: @entity3069 :: (1764,Species) :: ['Mycobacterium avium']


abstract: AIMS: The purpose of this single-cohort study was to implement and evaluate a programme that trains peers to deliver a @entity6 self-management support programme for South-Asian adults with @entity164 2 @entity6 and to assess the perceived efficacy of and satisfaction with this programme. METHODS: We recruited eight South-Asian adults who completed a 20-h peer-leader training programme conducted over five sessions (4 h per session). The programme used multiple instructional methods (quizzes, group brainstorming, skill building, group sharing, role-play and facilitation simulation) and provided communication, facilitation, and behaviour change skills training. To graduate, @entity1 were required to achieve the pre-established competency criteria in four training domains: active listening, empowerment-based facilitation, five-step behavioural goal-setting, and self-efficacy. @entity1 were given three attempts to pass each competency domain. RESULTS: On the first attempt six (75%), eight (100%), five (63%) and five (63%) @entity1 passed active listening, empowerment-based facilitation, five-step behavioural goal-setting, and self-efficacy, respectively. Those @entity1 who did not pass a competency domain on the first attempt were successful in passing on the second attempt. As a result, all eight @entity1 graduated from the training programme and became peer leaders. Satisfaction ratings for programme length, balance between content and skills development, and preparation for leading support activities were uniformly high. Ratings for the instructional methods ranged between effective and very effective. CONCLUSION: Findings suggest it is feasible to train and graduate peer leaders with the necessary skills to facilitate a @entity6 self-management support intervention.

title: Evaluating a XXXX self-management support peer leader training programme for the English- and Punjabi-speaking South-Asian community in Vancouver.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: @entity4373 ( @entity4373 ) significantly enhances transcriptome complexity and is differentially regulated in a wide variety of physiological processes in plants, including shoot growth. Presently, the functional implications and conservation of @entity4373 occurrences are not well understood in the @entity35735 genome. To analyze the global changes in @entity4373 during @entity35735 shoot growth, fast-growing shoots collected at seven different heights and culms after leaf expansion were sequenced using the Illumina HiSeq    2000 sequencing platform. It was found that approximately 60.74  % of all genes were alternatively spliced, with intron retention (IR) being the most frequent @entity4373 event (27.43  %). Statistical analysis demonstrated that variations of @entity4373 frequency and @entity4373 types were significantly correlated with changes in gene features and gene transcriptional level. According to the phylogenetic analysis of isoform expression data and @entity4373 frequency, the bamboo shoot growth could be divided into four different growth periods, including winter bamboo shoot (S1), early growth period (S2-S5), late growth period (S6 and S7), and mature period (CK). In addition, our data also showed that the winter bamboo shoot had the highest number of @entity4373 events. Twenty-six putative @entity563 / @entity369 -rich (SR) proteins were identified, producing a total of 109 transcripts. @entity4373 events were frequently and specifically regulated by SR splicing factors throughout shoot growth, resulting in changes to the original open reading frame (ORF) and subsequently changes to conserved domains. The @entity4373 product-isoforms showed regular expression change during the whole shoot growth period, thus influencing shoot growth. All together, these data indicate that @entity4373 events are adjusted to different growth stages, providing briefness and efficient means of gene regulation. This study will provide a very useful clue for future functional analyses.

title: Genome-wide analysis of shoot growth-associated alternative splicing in XXXX .

entities_list: @entity4373 :: ('MESH:C536589', 'Disease') :: ['Alternative splicing', 'AS']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['Serine']

answer: @entity35735 :: (38705,Species) :: ['moso bamboo']


abstract: We treated a @entity1 with a traumatic @entity13669 ( @entity13669 ) by embolization using a Tracker catheter and @entity902 coils by transarterial and transvenous approaches. A 65-year-old female sustained an injury in the right frontal region of the head in April, 1989. After 1 month, she was admitted to our hospital due to exophthalmos, congestion of the palpebral conjunctiva, ptosis, and a @entity2981 in the right frontal region of the head. Right carotid angiography showed a @entity13669 between the anterior ascending segment and the horizontal segment that drains into the superior @entity50 . To occlude the @entity292 , embolization was performed twice using @entity902 coils. In the first embolization, the cavernous sinus was approached transarterially and transvenously using a Tracker catheter system, and a total of 7 @entity902 coils were used for the embolization. The @entity2981 disappeared immediately after embolization but recurred 3 days after the operation. Angiography demonstrated re-communication of the @entity13669 . The second embolization was initially performed using a detachable balloon, but the balloon could not be passed through the @entity292 . Therefore, a Tracker catheter was advanced to the @entity292 transarterially and embolization was performed using 3 @entity902 coils. The @entity292 was occluded. Follow-up angiography after 1 year in August, 1990 showed complete occlusion of the @entity292 . The detachable balloon system was recently introduced in neurological and radiological departments, as a new surgical method for @entity13669 . At present, this method is the first choice for @entity13669 . However, the detachable balloon system presents some technical problems.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Embolization for traumatic carotid cavernous sinus @entity292 using XXXX coil].

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['ophthalmic vein, superior petrosal sinus and inferior petrosal sinus']

entities_list: @entity13669 :: ('MESH:D020216', 'Disease') :: ['carotid-cavernous fistula', 'CCF']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity902 :: (MESH:D010984,Chemical) :: ['platinum']


abstract: Infection with filarial parasites is associated with T cell hyporesponsiveness, which is thought to be partly mediated by their ability to induce regulatory T cells (Tregs) during @entity1 @entity281 . This study investigates the functional capacity of Tregs from different groups of filarial @entity1 to suppress filaria-specific immune responses during @entity1 @entity6565 . Microfilaremic (MF), @entity102 ( @entity102 ) and uninfected endemic normal (EN) individuals were selected in an area endemic for Brugia timori in Flores island, Indonesia. PBMC were isolated, CD4CD25(hi) cells were magnetically depleted and in vitro cytokine production and proliferation in response to @entity2757 adult worm antigen (BmA) were determined in total and Treg-depleted PBMC. In MF subjects BmA-specific T and B lymphocyte proliferation as well as @entity379 , @entity4047 and @entity4155 responses were lower compared to EN and @entity102 groups. Depletion of Tregs restored T cell as well as B cell proliferation in MF-positives, while proliferative responses in the other groups were not enhanced. BmA-induced @entity4047 production was increased after Treg removal in MF-positives only. Thus, filaria-associated Tregs were demonstrated to be functional in suppressing proliferation and possibly Th2 cytokine responses to BmA. These suppressive effects were only observed in the MF group and not in EN or @entity102 . These findings may be important when considering strategies for filarial treatment and the targeted prevention of filaria-induced @entity4269 .

title: Regulatory T cells in XXXX lymphatic filariasis: stronger functional activity in microfilaremics.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity6565 :: ('MESH:D005368', 'Disease') :: ['filariasis']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic pathology', 'CP']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: We report on a novel role for a pre-mRNA splicing component in genome stability. The @entity44281 protein, a component of an RNA polymerase II complex and required for transcription elongation, is also required for genome stability. Deletion of @entity44281 results in a 1,000-fold increase in genome instability, detected as direct-repeat instability. This instability can be suppressed by the high-copy-number @entity44282 gene, which is the @entity375 homologue of the @entity1 splicing factor @entity37519 . Although @entity44282 is essential, conditional alleles grown at the permissive temperature complement the essential function of @entity44282 yet reveal nonessential phenotypes. These studies have uncovered a role for @entity44282 in preventing genome instability. The genomic instability observed in @entity44282 mutants can be suppressed by high-copy-number @entity44281 . A deletion mutant of @entity15966 , a component of a PolII complex, is also unstable for direct repeats. This too is suppressed by high-copy-number @entity44282 . Thus, defects in both the transcriptional machinery and the pre-mRNA splicing machinery can be sources of genome instability. The ability of a pre-mRNA splicing factor to suppress the hyperrecombination phenotype of a defective PolII complex raises the possibility of integrating transcription, RNA processing, and genome stability or a second role for @entity44282 .

title: High-copy-number expression of Sub2p, a member of the RNA helicase superfamily, suppresses XXXX -mediated genomic instability.

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

answer: @entity44281 :: (9984,Gene) :: ['hpr1']


abstract: The aim of our study was to examine the relationship between bone mineral density (BMD) and serum ghrelin, @entity442 ( @entity442 ), @entity2301 ( @entity2301 ), and @entity251 levels in @entity1 at different stages of puberty. The study included 60 healthy nonobese Estonian schoolboys at the age of 10-18 years. Subjects were divided in three groups (20 @entity1 in each) based on the results of self-assessment using illustrated questionnaire of pubertal stage (G1, I; G2-G3, II; G3-G4, III). Morning fasting blood samples were collected for analysis of ghrelin, @entity251 , @entity442 , and @entity2301 . Total body BMD, lumbar BMD, lumbar apparent volumetric BMD (BMAD), and bone mineral content (BMC) were measured by DXA. Serum @entity251 concentration was the most important biochemical predictor of BMD in the total group, explaining 48.8% of variability in total body BMD, 51.4% in lumbar BMD, and 36.8% in lumbar BMAD. Body mass and height were both related to BMD and BMC throughout puberty. The serum @entity442 / @entity2301 ratio was correlated with serum @entity251 (r = 0.69) and ghrelin (r = -0.58) levels, but also with total BMD (r = 0.39), lumbar BMD (r = 0.42; P < 0.001 in all cases), BMAD (r = 0.29; P < 0.01), and total BMC (r = 0.48; P < 0.001). We conclude that serum @entity251 concentration and serum @entity442 / @entity2301 molar ratio are the major determinants of bone mineral density in @entity1 at different pubertal stages. Serum ghrelin concentration did not appear to have a direct independent effect on BMD. If present, the association may be mediated through sex hormones and the GH-IGF-I @entity2270 .

title: The influence of serum ghrelin, IGF XXXX and @entity251 on bone mineral density in @entity1 at different stages of sexual maturity.

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity2301 :: ('3486', 'Gene') :: ['IGFBP-3', 'IGF-binding protein 3']

entities_list: @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-1', 'IGF-1']

answer: @entity2270 :: (MESH:C566610,Disease) :: ['axis']


abstract: UNASSIGNED: Five new eriophyoid mite species (Eriophyidae) from @entity233 are described and illustrated in this paper: Aceria vanensis @entity8891 ., Aceria onosmae @entity8891 ., Aculus lydii @entity8891 ., Aculus gebeliae @entity8891 . and Aculus spectabilis @entity8891 .. The descriptions are based on the morphology of females collected from weedy plants, respectively: Amaranthus retroflexus L. (Amaranthaceae), Onosma isauricum Boiss. et Heldr. (Boraginaceae), Hypericum lydium Boiss. (Hypericaceae), Lotus gebelia Vent. (Fabaceae) and Stachys spectabilis Choisy ex DC. (Lamiaceae). The new species were found to be vagrant on their host plants with no visible damage symptoms observed.

title: Eriophyoid mites (Acari: Prostigmata: Eriophyoidea) from XXXX :  description of five new species.

answer: @entity233 :: (9103,Species) :: ['Turkey']


abstract: @entity755 is the ligand that mediates the clearance of low density lipoprotein (LDL) from the circulation by the @entity755 ,E (LDL) receptor pathway. Clearance is mediated by the interaction of a domain enriched in basic @entity535 residues on @entity755 with clusters of acidic residues on the @entity755 ,E (LDL) receptor. A model has been proposed for the @entity754 binding domain of @entity755 based on the primary @entity535 sequence (Knott, T. J., et al. 1986. Nature. 323: 734-738). Two clusters of basic residues (A: 3147-3157 and B: 3359-3367) are apposed on the surface of the LDL particle by a @entity1520 bridge between @entity2569 3167 and 3297. Support for this single domain model has been obtained from the mapping of epitopes for anti- @entity755 monoclonal antibodies that block the binding of @entity755 to the @entity754 . Here we test this model by comparing the @entity377 (from 9623 to 10,442) and @entity535 sequence (from 3139 to 3411) of @entity755 in seven species ( @entity1 , @entity1707 , @entity95 , @entity35 , @entity329 , @entity19 , and @entity1573 ). Overall, this region is highly conserved. Cluster B maintains a strong net positive charge and is homologous across species in both primary and secondary structure. However, the net positive charge of region A is not conserved across these species, but the region remains strongly hydrophilic. The secondary structure of the region between clusters A and B is preserved, but the @entity1520 bond is unique to the @entity1 sequence. This study suggests that the basic region B is primarily involved in the binding of @entity755 to the @entity755 ,E (LDL) receptor.

title: A cross-species comparison of the apolipoprotein B domain that binds to the XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity329 :: ('10036', 'Species') :: ['Syrian hamster']

entities_list: @entity1520 :: ('CHEBI:48343', 'Chemical') :: ['disulfide']

answer: @entity754 :: (3949,Gene) :: ['LDL receptor']


abstract: Early detection of premalignant and @entity5 of the uterine cervix and their distinction from benign mimics is crucial but sometimes difficult. In this study, we investigated utility of expression of @entity986 , @entity787 , Ki67, @entity876 and ER/PR in evaluating the benign, premalignant, and @entity5 of the uterine cervix. A total of 35 cervical cone or LEEP cases were collected including 14 @entity15709 ( @entity15709 ), 7 @entity2785 ( @entity2785 ), and 14 benign mimics (BM). A histological score for each case according to the criteria proposed by Silverberg group was assigned independently by 4 pathologists. Formalin-fixed, @entity982 -embedded sections were immunostained with @entity986 , @entity787 , @entity876 , Ki67, and ER/PR. Immunoreactivity was scored based on intensity (0 = none, 1 = mild, 2 = moderate, 3 = marked) and percentage of cells staining (0 = <1%,1 = 2-10%, 2 = 11-40%, 3 = >40%). A comparison of histological scores and immunoscores in 3 diagnostic categories was analysed. The histological scores assigned independently by 4 pathologists were all equal or above 6 for @entity15709 , between 3 and 5 for @entity2785 , and equal or below 3 for BM. There was increased expression of @entity986 and @entity787 in @entity2785 compared with BM (P < 0.05), with further increase in expression of these markers in @entity15709 compared with @entity2785 (P < 0.05). Ki67 expression was significantly increased in @entity15709 compared to @entity2785 (P < 0.05) as well as compared to BM (P < 0.05). Ki67 expression was only slightly increased in @entity2785 as compared to BM. There was a loss of ER/PR in cervical @entity15709 , but not in @entity2785 . Our results indicate that the Silverberg scoring system is a useful tool in differential diagnosis of @entity75 for increased diagnostic accuracy and interobserver agreement. Most @entity75 can be differentiated by using a combination of histological scores with a panel of immunomarkers.

title: Utility of @entity986 , @entity787 , Ki67, @entity876 and ER/PR in the differential diagnosis of benign, premalignant, and @entity5 of the uterine cervix and their relationship with Silverberg scoring system for XXXX .

entities_list: @entity2785 :: ('MESH:D009375', 'Disease') :: ['endocervical glandular dysplasia', 'EGD']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant glandular lesions']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cervical glandular lesions']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity15709 :: ('MESH:D065311', 'Disease') :: ['AIS', 'adenocarcinoma in situ']

answer: @entity75 :: (MESH:D001927,Disease) :: ['endocervical glandular lesions']


abstract: Experimental studies on small blood vessels of the @entity35 mesentery were performed in order to optimize current clinical argon laser coagulation technique of @entity2194 . The vessel effects were observed by means of vital microscopy and histological studies were done on coagulated vessels. Furthermore systematic variation of the coagulation parameters was done. The main results were as follows: Graded effects such as reversible vasoconstriction, endovascular @entity715 and complete separation of the vessel wall could be achieved with the argon laser on small vessels in surroundings of relatively low absorption. Short duration vessel closure resulted from endovascular @entity715 alone or in conjunction with downstream vasoconstrictions. Destroyed erythrocytes adhering to the vessel wall played a major role in endovascular @entity715 . Subendothelial structures were of minor importance. Longer lasting vessel closure could be achieved by summation of the effects of single exposures. Low risk @entity3459 is only possible at exposure times of less than 20 msec. Currently available clinical argon lasers do not deliver the high laser powers needed for this purpose.

title: [Blood XXXX with the argon laser].

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular neovascularization']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['vessel coagulation']

answer: @entity3459 :: (MESH:D025861,Disease) :: ['vessel coagulation']


abstract: PURPOSE: The purpose of this study was to determine the type and frequency of characteristic bone and soft tissue changes on MRI of @entity1 with a clinical diagnosis of @entity3444 . MATERIALS AND METHODS: 28 @entity1 with a clinical diagnosis of @entity3444 underwent MR imaging. Besides T1- and T2-weighted sequences, short-tau-inversion-recovery sequences were used routinely. In 27 @entity1 T1-weighted images after intravenous contrast injection were acquired additionally. As a control group the images of 15 @entity1 without clinical signs for @entity3444 were evaluated. RESULTS: In 25 of 28 cases (89%) the clinical diagnosis of @entity3444 was established by MR imaging. The most common finding was a peritendinous @entity4 at the calcaneal insertion site which was found in all 25 @entity1 . In 19 of 25 cases (76%) a @entity236 of the calcaneus was present. In 14 of 25 cases (56%) an intratendinous signal intensity @entity101 could be observed which showed contrast enhancement in 12 cases. Compared to the control group (mean thickness 3.3 mm) the @entity1411 showed significant thickening in the 25 MR positive @entity1 (mean thickness 6.72 mm). DISCUSSION: Besides thickening of the @entity1411 and intratendinous signal intensity increase with contrast enhancement to some extent, @entity236 of the calcaneus and peritendinous @entity4 are characteristic signs of @entity3444 on MRI. Both signs can reliably be seen on STIR sequences only.

title: [MRI of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increase of the plantar fascia']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['edema', 'edema close to the plantar fascia']

entities_list: @entity3444 :: ('MESH:D036981', 'Disease') :: ['plantar fasciitis']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow edema']

entities_list: @entity1411 :: ('MESH:D016523', 'Disease') :: ['plantar fascia']

answer: @entity3444 :: (MESH:D036981,Disease) :: ['plantar fasciitis']


abstract: OBJECTIVE: To evaluate whether @entity1 epididymis protein 4 ( @entity3422 ) and @entity10224 correlate with known high-risk prognostic factors for @entity1204 . DESIGN: Prospective multicenter study. SETTING: Three Danish tertiary gynecological oncology centers. POPULATION: A total of 352 @entity1 with @entity1204 and atypical @entity1869 consecutively referred between 1 September 2009 and 1 January 2012. METHODS: Preoperative blood samples were obtained from all @entity1 . Biomarker levels were correlated with pathological characteristics of hysterectomy specimens. MAIN OUTCOME MEASURES: FIGO stage, depth of @entity3 , cervical involvement, lymph node @entity3 , and histological type and grade of @entity5 . RESULTS: We found that both @entity3422 and @entity10224 were significantly positively correlated with histological grade ( @entity3422 : p  =  0.002 and @entity10224 : p  =  0.027), lymph node @entity3 ( @entity3422 : p  =  0.013 and @entity10224 : p  <  0.0001), @entity3 (p  <  0.0001) and cervical involvement (p  <  0.0001). Furthermore, a significant increase was found with increasing FIGO stage for both markers (p  <  0.0001). In a combined index including age, the diagnostic value increases. Area under the receiver operating characteristics curves were higher for the index compared with the markers individually for all our endpoints. The calculated plots for the combined index may assist gynecologists in predicting the risk of deep @entity3 , cervical involvement and lymph node @entity3 . The analyses emphasize that the combined markers should be used in the prediction of prognostic factors. CONCLUSION: This study confirmed that the markers are significantly elevated in @entity1 with prognostic high-risk factors and may, therefore, be used as an additional tool in combination with imaging and clinical information when planning the treatment of @entity1204 @entity1 .

title: @entity3422 and XXXX levels in the preoperative assessment of @entity1204 @entity1 : a prospective multicenter study (ENDOMET).

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity1869 :: ('MESH:D004714', 'Disease') :: ['endometrial hyperplasia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'myometrial invasion']

answer: @entity10224 :: (94025,Gene) :: ['CA125']


abstract: PURPOSE: To determine the relationship between preoperative serum albumin and @entity86 as well as surgical outcomes in right-sided @entity694 @entity1 . METHODS: This retrospective study in a university hospital included 84 @entity1 who underwent elective right hemicolectomy for @entity420 of the right-sided colon between January 2004 and December 2005. The @entity1 had a preoperative serum albumin assessment. Serum albumin less than 3.5 g/dL was regarded as @entity4988 . Postoperative outcomes were classified into mortality, morbidity (infectious and noninfectious complications), time to first bowel movement, time to resume normal diet, and hospital stay. RESULTS: Forty males (48%) and forty-four females (52%) with a mean age of 64 (range, 27-89) years were included. Forty-eight @entity1 (57%) had @entity4988 . No 30-day postoperative mortality occurred. All 14 @entity260 occurred in hypoalbuminemic cases. Therefore, 29% of the hypoalbuminemics had complications whereas none occurred in nonhypoalbuminemics (p=0.001). In univariate analysis, @entity4988 and @entity260 were the risk factors for delayed postoperative recovery of bowel function and prolonged length of hospital stay. In multivariate analysis, @entity4988 was the significant risk factor for @entity260 (p<0.001) and delayed time to first bowel movement (p=0.018) whereas @entity260 were the significant risk factor for delayed time to resume normal diet (p<0.001) and prolonged hospital stay (p<0.001). CONCLUSION: @entity4988 is a potential predictor of delayed recovery of bowel function postoperatively and significantly associated with @entity260 in right-sided @entity694 @entity1 undergone right hemicolectomy.

title: XXXX is a predictor of delayed @entity86 and poor surgical outcomes in right-sided @entity694 @entity1 .

entities_list: @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia', 'Hypoalbuminemia']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative bowel function']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity4988 :: (MESH:D034141,Disease) :: ['Hypoalbuminemia']


abstract: BACKGROUND: This analysis sought to determine whether @entity2934 influences time to response or rate of response in elderly @entity308 @entity1 receiving @entity5080 and psychotherapy and to examine clinical and polysomnographic correlates of @entity2934 treatment. METHOD: @entity1 with recurrent major @entity308 (N = 119; mean +/- SD age = 68.0 +/- 6.1 years; diagnosis defined by Research Diagnostic Criteria) received acute treatment with @entity5080 and interpersonal psychotherapy. Thirty-five @entity1 received open-label adjunctive @entity2934 for @entity148 or @entity22 symptoms (LZ+) and 84 did not. Statistical analyses were conducted between the LZ+ group and a group of 35 @entity1 who received no @entity2934 (LZ-) and were matched for @entity148 level. @entity1 had polysomnographic studies prior to treatment and after remission of @entity308 . RESULTS: The LZ+ group reported more @entity148 on the Brief Symptom Inventory (p = .04) compared with the remaining 84 @entity1 . The LZ+ group had a greater proportion of @entity308 subtype than the @entity148 -matched LZ- group, in addition to more abnormal EEG sleep (higher percentage of REM sleep, shorter REM latency, lower delta sleep ratio). Mean time to initial antidepressant response was no different between groups. However, a significantly greater proportion of LZ+ than LZ- @entity1 responded to acute treatment (91.4% vs. 71.4%; p < .03). CONCLUSION: Adjunctive @entity2934 does not slow the antidepressant response to combined antidepressant/psychotherapy treatment in elderly @entity308 @entity1 , and it is associated with a greater likelihood of antidepressant response. A greater percentage of @entity1 treated with @entity2934 have @entity308 subtype and abnormal sleep findings (EEG) than those who are not treated with @entity2934 . Adjunctive @entity2934 is useful for treating @entity148 in elderly @entity308 @entity1 .

title: Does XXXX impair the antidepressant response to @entity5080 and psychotherapy?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder', 'depressive symptoms', 'depressed', 'endogenous depression']

entities_list: @entity5080 :: ('MESH:D009661', 'Chemical') :: ['nortriptyline']

entities_list: @entity2934 :: ('MESH:D008140', 'Chemical') :: ['lorazepam']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity2934 :: (MESH:D008140,Chemical) :: ['lorazepam']


abstract: BACKGROUND: Certain diuretics such as @entity1483 , when inhaled, have been found to be useful in preventing @entity7047 ( @entity7047 ). STUDY OBJECTIVE: To assess the possible preventive effect of inhaled @entity6478 in @entity7047 . DESIGN: A double blind, randomized, cross-over study comparing the effect of inhaled @entity6478 , inhaled @entity1483 and placebo in @entity7047 . @entity1 : Sixteen @entity748 @entity1 (8 males and 8 females) with an average age of 21 years (range 9-31) who presented a FEV1 decrease of over 15% in a previous free-running exercise test. INTERVENTIONS: Solutions were inhaled with a Hudson nebulizer connected to an @entity26 source in different days before exercise testing. A Vitalograph Compact (Ohmeda, England) spirometer was used and FEV1 was obtained at baseline, three minutes after solution inhalation, immediately after exercise and then every 5 min. until 20 minutes post-exercise. The changes in FEV1 percentages (FEV1%) and the mean FEV1 decreases expressed as percentages for each solution were compared. RESULTS: Inhaled @entity1483 diminished the fall in the FEV1 at every time after exercise. The maximum decrease in mean FEV1 was at 5 minutes post-exercise and was 11 +/- 7% with @entity1483 , 24 +/- 14% (p < 0.01) with @entity6478 and 19 +/- 12% (p < 0.05) with placebo. @entity6478 administration resulted in a slight but significative increase in the FEV1 fall (p < 0.01 when compared with placebo). CONCLUSIONS: @entity6478 is not useful to protect @entity7047 whereas @entity1483 does it. These differences results may be related to the differents mechanisms of action of the two diuretics.

title: Comparative study of inhaled @entity6478 and inhaled XXXX in exercise-induced asthma.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide', 'Furosemide']

entities_list: @entity6478 :: ('MESH:D000584', 'Chemical') :: ['Amiloride', 'amiloride']

entities_list: @entity7047 :: ('MESH:D001250', 'Disease') :: ['Exercise-Induced Asthma', 'EIA']

answer: @entity1483 :: (MESH:D005665,Chemical) :: ['furosemide']


abstract: BACKGROUND: To review the initial treatment results of intensity-modulated radiotherapy (IMRT) for @entity263 . METHODS: Ninety-two @entity1 treated with IMRT before July 2003 were included in this study. The median follow-up was 32 months. The indications for IMRT included primary, adjuvant, and salvage treatment. Combined treatment with @entity342 suppression therapy was variable. The primary study endpoints were chronic adverse events which were subjectively reported. Only @entity1 with an @entity420 and who had been treated by primary radiotherapy were included in the analysis of disease relapse. RESULTS: At the time of analysis, 89 @entity1 were still alive, and only 2 @entity1 had died of @entity263 . In the survival analysis, the 30-month failure-free survival rates were 100%, 89.2%, and 67.3% for the low-, intermediate-, and high-risk groups of @entity1 , respectively. Pretreatment PSA level, Gleason score, risk classification, and adjuvant hormone therapy were significantly associated with relapse according to the univariate analysis, while only risk classification remained significant in the multivariate analysis. During follow-up, 5 (6%) @entity1 developed grade 2 gastrointestinal (GI) adverse events (AE). Sixteen (18%) and 7 (8%) @entity1 developed grade 2 and 3 urinary AE, respectively. Development of severe urinary adverse events was closely related to previous surgical treatment. No factor was identified as being correlated with the GI adverse events. The preservation rate of sexual function was 25.7%. CONCLUSIONS: Seventy-two Grays of irradiation, administered by IMRT, is a safe method as the primary treatment for @entity263 . However, severe urinary @entity137 was related to previous surgical treatment. There is a need for longer follow-up periods to verity the benetit of this dosage level.

title: Preliminary treatment results of intensity-modulated radiotherapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: It was hypothesized that EMG biofeedback relaxation training, applied to a @entity6 @entity1 , would result in a decreased level of insulin with fewer episodes of @entity1270 . A 20-year-old female, @entity6 since age nine, kept daily records of insulin doses and rated herself on an emotionality and a @entity6 scale. A full-semester baseline was taken. This was followed by a semester-long training program during which the @entity1 practiced relaxing her frontalis muscle with a portable EMG feedback unit which produced a geiger-counter-like click feedback. A cassette-tape series was used along with the portable EMG. The @entity1 was encouraged to practice twice each day and to attempt to maintain a relaxed state even when not in the practice situation. The daily use of the portable unit was terminated at the end of the semester. In addition, the @entity1 ceased practicing twice daily with the cassette tape. Daily insulin averaged 85 units for the six-week baseline and 59 for the final six weeks of the training period. Moreover, at the end of the training period the average dose had reached 43 units. During the training period the @entity1 rated herself as @entity393 and in @entity6 .

title: Effects of an EMG biofeedback relaxation program on the control of XXXX : a case study.

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['decreasing in emotionality']

entities_list: @entity1270 :: ('MESH:D007662', 'Disease') :: ['ketoacidosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetic fluctuations']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: We followed 49 @entity1 who underwent a minimum of 2 years @entity172 replacement therapy (ERT) after diagnosis and treatment for localized @entity0 . Forty-three @entity1 were treated with oral ERT. In this group, the median age at the time of @entity5 diagnosis was 46 years (range 26 to 66 years), and ERT was begun a median of 84 months after diagnosis (range 0 to 286 months). The @entity1 were followed for a median of 144 months after @entity5 diagnosis (range 46 to 324 months), and the median duration of ERT was 31 months (range 24 to 142 months). For six @entity1 , ERT was administered as a vaginal cream application. In this group, the median age at time of @entity5 diagnosis was 46 years (range 38 to 57 years), and ERT was begun a median of 49 months after diagnosis (range 24 to 61 months). The @entity1 were followed for a median of 95 months after @entity5 diagnosis (range 72 to 154 months), and the median duration of ERT was 47 months (range 27 to 80 months). One @entity1 experienced disease recurrence; she had received surgery for a stage I, @entity172 receptor (ER)-positive lesion. The @entity1 began ERT 30 months after @entity5 diagnosis and developed a recurrent @entity5 56 months after initiation of ERT. She remained alive without evidence of disease for 10 years since initial diagnosis of @entity0 . Despite the inherent limitations of retrospective experiential data and the need for prospective, randomized trials to assess the safety of ERT, the present observations suggest that ERT does not appear to have a pronounced adverse effect on @entity5 outcome. Nevertheless, until appropriate clinical trials determine that ERT is safe, caution is needed.

title: @entity172 replacement therapy in XXXX with prior diagnosis and treatment for @entity0 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'ER-negative tumor']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: PURPOSE: To determine the incidence and significance of @entity1416 resulting from surgical thrombectomy/revision of hemodialysis grafts. This information may help in determining the significance and management of similar emboli resulting from percutaneous hemodialysis graft thrombolysis. @entity1 AND METHODS: @entity1 undergoing surgical thrombectomy/revision of clotted hemodialysis grafts are studied with postoperative fistulography per institutional protocol whenever possible. For this retrospective study, all postoperative fistulograms from a 1-year period were reviewed for the presence of @entity1416 . @entity1 with documented @entity1416 were examined for evidence of hand/digital @entity63 ; only those @entity1 with signs or symptoms of @entity63 were treated. At clinical follow-up, repeated evaluation for hand/digital @entity63 was performed. RESULTS: Ninety-one thrombectomy/revision procedures were performed during the study period. Postoperative fistulograms were obtained after 67 of these procedures in 32 @entity1 . One @entity1 complained of hand @entity158 during dialysis prior to acquisition of the postoperative fistulogram. Arterial emboli were documented in eight @entity1 (12%; brachial, n = 3; radial, n = 2; ulnar, n = 2; radial/ulnar, n = 1). The single symptomatic brachial embolus was percutaneously removed; no intervention was undertaken in the remainder. At mean follow-up of 14 months, no @entity1 had developed hand or digital @entity63 . Subsequent fistulograms demonstrated partial (n = 2) or complete (n = 2) resolution of the untreated emboli. CONCLUSION: Arterial emboli are a relatively common occurrence with surgical thrombectomy/revision. Conservative management appears to be indicated in asymptomatic @entity1 .

title: Incidence and management of XXXX from hemodialysis graft surgical thrombectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial emboli']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

answer: @entity1416 :: (MESH:D020762,Disease) :: ['arterial emboli']


abstract: AIMS/HYPOTHESIS: The effects of successful pancreas transplant alone ( @entity865 ) on chronic complications of @entity6 , in particular @entity6 , remain disputed. We prospectively studied the course of @entity6 in @entity865 recipients and in non-transplanted (non- @entity865 ) type 1 @entity6 @entity1 . METHODS: The @entity865 and non- @entity865 groups consisted respectively of 33 (follow-up: 30 +/- 11 months) and 35 @entity1 (follow-up: 28 +/- 10 months). Best corrected visual acuity, slit lamp examination, intraocular pressure measurement, ophthalmoscopy, retinal photographs, and in selected cases angiography were performed. @entity6 and its improvement/deterioration were assessed according to criteria proposed by the Eurodiab Study. RESULTS: At baseline, 9% of @entity865 and 6% of non- @entity865 @entity1 had no @entity6 , 24 and 29% had non-proliferative @entity6 (NPDR), whereas 67 and 66% had laser-treated and/or proliferative @entity6 (LT/PDR), respectively. No new case of @entity6 occurred in either group during follow-up. In the NPDR @entity865 group, 50% of @entity1 improved by one grading, and 50% showed no change. In the LT/PDR @entity865 , stabilisation was observed in 86% of cases, whereas worsening of @entity989 occurred in 14% of @entity1 . In the NPDR non- @entity865 group, @entity6 improved in 20% of @entity1 , remained unchanged in 10%, and worsened in the remaining 70%. In the LT/PDR non- @entity865 group, @entity989 did not change in 43% and deteriorated in 57% of @entity1 . Overall, the percentage of @entity1 with improved or stabilised @entity6 was significantly higher in the @entity865 group. No differences were found between the two groups with regard to @entity231 lesions and intraocular pressure values. CONCLUSIONS/INTERPRETATION: Despite a relatively short follow-up, our study shows that successful @entity865 can positively affect the course of @entity6 .

title: Pancreas transplant alone has beneficial effects on XXXX in type 1 @entity6 @entity1 .

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes', 'Diabetic retinopathy', 'diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

answer: @entity989 :: (MESH:D012164,Disease) :: ['retinopathy']


abstract: BACKGROUND: In this study we investigated whether the addition of peak @entity26 consumption (VO(2)) improves the predictive accuracy of the Seattle @entity712 Model (SHFM). The SHFM is a validated multivariate risk model that uses NYHA classification to assess functional capacity rather than peak @entity26 consumption (VO(2)). METHODS: Outpatients (n = 1,240) evaluated for transplant at three centers had their SHFM score calculated and peak VO(2) measured. The outcomes assessed were @entity204 /LVAD/urgent transplant with censoring at the time of elective transplant. RESULTS: Over the course of 4.0 (mean) years of observation, there were 571 events. Both the SHFM score (  (2) = 227) and peak @entity4962 (  (2) = 88, both p < 0.0001) were highly predictive of outcomes. The SHFM and peak VO(2) were modestly correlated (r = 0.39, p < 0.0001). In a multivariate Cox model, peak VO(2) added to the SHFM with a hazard ratio of 0.949 (p < 0.0001) for each 1-ml/kg/min increase. Peak VO(2) improved both the net reclassification improvement and integrated discrimination index (both p  <= 0.0002). Peak VO(2) provided additive prognostic information within each SHFM score (p < 0.05). The 1-year areas under the receiver-operating characteristic curve were obtained for peak @entity4962 (0.645, 95% CI 0.606 to 0.684), SHFM (0.758, 95% CI 0.721 to 0.795) and SHFM with peak @entity4962 (0.766, 95% CI 0.731 to 0.802). The SHFM-predicted vs actual survival free of LVAD/UNOS Status 1 transplant at 1 year (86% vs 83%) and 4 years (63% vs 63%) were similar. CONCLUSIONS: The multivariate SHFM is a powerful predictor of @entity204 /LVAD/urgent transplant. Peak VO(2) adds prognostic information across the spectrum of the SHFM, but changes in decision regarding transplant listing occur mainly in moderate-risk @entity1 .

title: Prognostic impact of the addition of peak @entity26 consumption to the Seattle XXXX Model in a transplant referral population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart Failure']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

answer: @entity712 :: (MESH:D006333,Disease) :: ['Heart Failure']


abstract: Although anti- @entity470 therapy has established efficacy in metastatic @entity14 , only 10-20% of unselected @entity1 respond. This is partly due to @entity984 and @entity817 mutations, which are currently assessed in the @entity5 . To improve @entity1 selection, assessing mutation status in circulating @entity5 cells (CTCs), which possibly better represent metastases than the @entity5 , could be advantageous. We investigated the feasibility of @entity984 and @entity817 mutation detection in colorectal CTCs by comparing three sensitive methods and compared mutation status in matching @entity5 , liver @entity3 and CTCs. CTCs were isolated from blood drawn from 49 @entity1 before liver resection using CellSearch   . DNA and RNA was isolated from @entity5 , metastases and CTCs. Mutations were assessed by co-amplification at lower denaturation temperature-PCR (Transgenomic   ), real-time PCR (EntroGen   ) and nested Allele-Specific Blocker (ASB-)PCR and confirmed by Sanger sequencing. In 43 of the 49 @entity1 , tissue RNA and DNA was of sufficient quantity and quality. In these 43 @entity1 , discordance between primary and @entity3 was 23% for @entity984 and 7% for @entity817 mutations. RNA and DNA from CTCs was available from 42 of the 43 @entity1 , in which ASB-PCR was able to detect the most mutations. Inconclusive results in @entity1 with low CTC counts limited the interpretation of discrepancies between tissue and CTCs. Determination of @entity984 and @entity817 mutations in CTCs is challenging but feasible. Of the tested methods, nested ASB-PCR, enabling detection of @entity984 and @entity817 mutations in @entity1 with as little as two CTCs, seems to be superior.

title: @entity984 and @entity817 mutation status in circulating XXXX cells and their correlation with primary and @entity3 tissue.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'primary tumor']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic tumor']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal tumor']


abstract: Single doses of the drug @entity900 and its analogues @entity3003 and @entity15985 were administered to tumour-bearing @entity35 . The @entity5 used were two @entity957 , that are part of a panel of @entity5 developed at this institute. @entity900 resulted in severe nephrotoxicity. @entity3003 and @entity15985 were less nephrotoxic, but resulted in acute gastrointestinal and (probably) hematological @entity137 . @entity3003 also caused late occurring @entity409 . The responses of the @entity5 were compared at the level of maximum tolerated drug doses for early @entity137 . The level of response was different for the two @entity5 . One was more sensitive to the drugs than the other. The effects of @entity900 and @entity3003 were approximately similar. @entity15985 was less effective. Because @entity900 caused more severe late @entity137 , it is concluded that @entity3003 has the best therapeutic index for these two @entity5 .

title: @entity5 growth delay and normal tissue XXXX induced by three cytotoxic platinum drugs.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['experimental lung tumours', 'lung tumours', 'tumours']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['Carboplatin', 'carboplatin']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['bronchial squamous cell carcinomas']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage']

entities_list: @entity15985 :: ('MESH:C023359', 'Chemical') :: ['Iproplatin', 'iproplatin']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: Survivin has been widely reported to play a role in diagnosis and prognosis of @entity150 @entity1 . However, published data on this subject are heterogeneous. Here, we conducted a meta-analysis to obtain a complete evaluation of the association between survivin and @entity1349 ( @entity1349 ), @entity66 ( @entity66 ), @entity1349 ( @entity1349 ), and odds ratio (OR) in @entity150 @entity1 . Published studies on this subject were selected for further assessment by online articles in PubMed, MEDLINE, EMBASE, and OVID databases. Pooled hazard ratios (HR) with 95 % confidence interval (95 % CI) were estimated. Funnel plots were used to evaluate the publication bias. As well, heterogeneity and sensitivity were analyzed. In this meta-analysis, we included 13 studies with the total number of 1,963 @entity1 . Positive survivin expression in @entity150 was associated with a poor @entity1349 (HR, 1.831; 95 % CI, 1.344-2.49), @entity66 (HR, 1.721; 95 % CI, 1.477-2.004), or @entity1349 (HR, 1.753; 95 % CI, 1.092-2.816) in @entity1 . In addition, a significant association between expression of survivin and age (OR, 0.641; 95 % CI, 0.416-0.987) as well as stage (OR, 0.37; 95 % CI, 0.190-0.750) was revealed. Heterogeneity was observed among the included studies with @entity1349 (x (2)   =29.58, p = 0.009, I (2)   = 52.7 %), @entity1349 (x (2)   = 15.67, p = 0.008, I (2)   = 68.1 %), and stage (x (2)   = 11.97, p = 0.035, I (2)   = 58.2 %). There was no publication bias according to Begg's and Egger's tests except for studies with gender. Furthermore, sensitivity analysis obtained the source of heterogeneity and confirmed opposite results of some studies. This study suggests that expression of survivin indicates poor prognosis in older @entity1 and muscle invasive or advanced stage in @entity150 . Survivin expression could be used in identifying a subgroup of @entity1 with potential to benefit from a targeted therapy against survivin.

title: Prognostic and clinicopathological significance of survivin expression in @entity150 XXXX : a meta-analysis.

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['DSS', 'disease-specific survival']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Aloe vera has been recognized as a valuable medicinal plant for the treatment of burns. Extensive studies have described its antiinflammatory, wound healing and related activities, but the instability of aloe gel confuses pharmacological data, leads to inconsistency in treatments and inconvenience in daily preparation. These obstacles prompted us to develop a stable aloe preparation, aloe cream, that we tested on artificial thermal burns in @entity19 . Aloe cream when applied immediately to @entity4808 delayed progressive damage and accelerated the healing rate more effectively than fresh aloe gel. Both aloe cream and fresh aloe gel prevented further @entity272 and casting of dead epidermis was less than in control. For second degree burns the healing rate was enhanced by aloe cream and fresh aloe gel: less @entity32 was observed in areas treated with either of these than in untreated areas or those treated with the cream base. For @entity4808 the efficacy of aloe cream and fresh aloe gel could not be evaluated statistically because of @entity281 . It was observed that aloe cream enhanced epithelialization but failed to show antiinflammatory activity. No differences in epithelialization and @entity32 were observed among @entity19 treated with fresh aloe gel, cream base or control. All these findings confirm that Aloe vera gel is effective for burn treatment if it is well preserved.

title: The efficacy of Aloe vera cream in the treatment of first, second and @entity4808 in XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity4808 :: ('MESH:D002056', 'Disease') :: ['first degree burns', 'third degree burns']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin damage']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: The @entity137 and horizontal transfer of a new formulation of @entity276 , 0.5% @entity276 dust, was tested against @entity2442 Shiraki in the laboratory. The formulation was applied in three different ways: 1) Directly applied to termites (donors) and mixed with untreated termites (recipients) at three ratios, viz., 50 donors: 50 recipients, 20 donors: 80 recipients and 10 donors: 90 recipients. 2) Applied onto the surface of 3 mm thick sand or soil substrate in a petri dish and then topped with another 3 mm thick sand or soil layer whereupon termites were released. 3) Applied to the inner surface of a tube (either 5 cm or 15 cm long) that connected two foraging dishes, one containing dry sand and the other moist sand plus a @entity616 and termites were released into the dry sand dish. All donors and >93% of the recipients were dead by 42 h after treatment in the direct treatment experiment. Significant mortalities of both donors and recipients were observed at 5 h after treatment at all donor: recipient ratios. During this period, the mortality of the recipients (but not donors) at 10:90 was significantly lower than those at the other two ratios. All termites were dead at 65 @entity926 ( @entity926 ) on the sand treatment and at 190 @entity926 on soil treatment. More than 96% mortality was observed at 40 @entity926 on the sand treatment as compared with only 6% mortality onsoil treatment during the same time period. In the tube treatment experiment, > 97% mortality was observed at 90 h after release for both tube lengths as compared with < 3% mortality in controls. About half of the termites were dead by 15 h after release regardless of the tube length. Our results showed that 0.5% @entity276 dust is nonrepellent and readily transferred from treated to nontreated termites.

title: @entity137 and horizontal transfer of 0.5% @entity276 dust against XXXX .

entities_list: @entity276 :: ('MESH:C082360', 'Chemical') :: ['fipronil']

entities_list: @entity2442 :: ('36987', 'Species') :: ['Coptotermes formosanus']

entities_list: @entity926 :: ('MESH:C537268', 'Disease') :: ['HAE', 'h after exposure']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['wood block']

answer: @entity2442 :: (36987,Species) :: ['Formosan subterranean termites']


abstract: 1. Peripheral blood mononuclear cells from eight healthy volunteers were cultured, with or without concanavalin A (Con A), in a medium containing (ml/l) 100 normal autologous serum, 100 experimental autologous serum or 100 heterologous (fetal calf) serum. 2. The control and experimental autologous sera were obtained from the volunteers, before and after 15 d supplementation with 15 g fish oil (MaxEPA)/d to provide 1.5 g @entity7784 ( @entity8393 ; 20:5n-3)/d. The sera were frozen at -20 degrees. The level of @entity8393 increased from trace quantities in the control autologous serum to 14.3% w/w free @entity1718 and between 6.9 and 8.1% w/w lipoprotein phospholipids in the experimental autologous serum. The heterologous fetal calf serum was enriched with @entity8393 , complexed with bovine serum albumin, to provide a final concentration of 15 micrograms/ml. All culture medium contained 10 ml fresh autologous serum/l and cells were obtained from the volunteers for the culture studies about 60 d after the end of @entity8393 supplementation. 3. Portions of cells were removed from culture at 36, 48 and 72 h for phospholipid @entity844 analysis. 4. The level of @entity8393 in phospholipids of cells cultured with exogenous @entity8393 in fetal calf serum was increased significantly (P less than 0.05) at all sampling times, both with and without Con A. By 48 h the levels had peaked at 15.8 (SE 2.7) and 18.4 ( @entity19 )% w/w respectively. 5. Resting cells, i.e. with no Con A present, failed to accumulate @entity8393 when cultured in the experimental autologous serum containing 8.6% w/w total lipids as endogenous @entity8393 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Uptake of exogenous and endogenous XXXX by cultured human mononuclear cells.

entities_list: @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

answer: @entity7784 :: (MESH:D015118,Chemical) :: ['eicosapentaenoic acid']


abstract: BACKGROUND: Intranasal glucocorticoids represent the most effective pharmacologic treatment of @entity2023 . So far, no clinical data are available that compare @entity14680 (FF) with other intranasally applied glucocorticoids. OBJECTIVE: Because the pharmacokinetic behaviour of drugs governs their presence at the therapeutic target site we analysed selected in vitro properties of FF in comparison with @entity2995 ( @entity2974 ), @entity4184 (Bud), @entity5023 (FP) and @entity10438 (MF). Additionally, we determined the anti-inflammatory activity of the glucocorticoid fraction residing in @entity1 nasal tissue samples after washing. METHODS: We analysed the solubility of the compounds in artificial @entity1 nasal fluid and the retention in @entity1 nasal tissue as well as typical spray volumes of commercially available drug preparations. As an anti-inflammatory measure, we evaluated the inhibition of @entity687 release from epithelial cells. RESULTS: FF is delivered in the smallest application volume per spray. Despite the low aqueous solubility of glucocorticoids, a fraction of the compounds is already dissolved in the aqueous supernatants of drug preparations (Bud> @entity2974 >FP>MF>FF). The dissolution of FP, MF and FF was significantly enhanced in artificial nasal fluid and FF displayed the most pronounced enhancement of solubility in the presence of proteins. Consistent with this result, the highest retention in nasal tissue was observed for FF, followed by FP>MF>Bud> @entity2974 . After washing of the nasal tissue samples, all compounds inhibited @entity687 release, with FF displaying the highest activity. CONCLUSION: FF displayed beneficial properties for nasal application. Its low application volume per spray is a prerequisite for effective drug utilization by avoiding immediate loss by nose runoff or drip down the throat. Sustained dissolution and high tissue binding of FF should contribute towards an extended presence of compounds in nasal tissue as a basis for a prolonged pharmacologic activity.

title: Dissolution in nasal fluid, retention and anti-inflammatory activity of XXXX in @entity1 nasal tissue ex vivo.

entities_list: @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis']

entities_list: @entity4184 :: ('MESH:D019819', 'Chemical') :: ['budesonide']

entities_list: @entity14680 :: ('MESH:C523187', 'Chemical') :: ['fluticasone furoate']

entities_list: @entity5023 :: ('MESH:C065382', 'Chemical') :: ['fluticasone propionate']

entities_list: @entity10438 :: ('MESH:C053915', 'Chemical') :: ['mometasone furoate']

answer: @entity14680 :: (MESH:C523187,Chemical) :: ['fluticasone furoate']


abstract: Probiotics and milk @entity460 may increase resistance to @entity281 , but their effect on growth and @entity68 and @entity219 status of Indonesian @entity1 is uncertain. We investigated the hypotheses that @entity291 milk with added probiotics would improve growth and @entity68 and @entity219 status of Indonesian @entity1 , whereas milk @entity460 alone would improve growth but reduce @entity68 and @entity219 status. A 6-mo randomized trial was conducted in low-socioeconomic urban communities of Jakarta. Healthy @entity1 (n = 494) were randomly assigned to receive low- @entity1132 milk with a low @entity460 content of    50 mg/d (LC; n = 124), a regular @entity460 content of    440 mg/d (RC group; n = 126), regular @entity460 with 5   10(8) CFU/d @entity6329 @entity6329 CRL 431 ( @entity6329 ; n = 120), or regular @entity460 with 5   10(8) CFU/d @entity6374 DSM 17938 ( @entity6374 ; n = 124). Growth, @entity417 , and @entity68 and @entity219 status were assessed before and after the intervention. Compared with the RC group, the @entity6374 group had significantly greater @entity1017 [0.22 (95% CI: 0.02, 0.42) kg], weight-for-age Z-score (WAZ) changes [0.09 (95% CI: 0.01, 0.17)], and monthly weight [0.03 (95% CI: 0.002, 0.05) kg/mo] and height [0.03 (95% CI: 0.01, 0.05) cm/mo] velocities. @entity6329 significantly increased monthly weight velocity [0.03 (95% CI: 0.001, 0.05) kg/mo], but not height. However, the changes in underweight, stunting, @entity417 prevalence, and @entity68 and @entity219 status were similar between groups. In conclusion, @entity6374 DSM 17938 modestly improved growth by increasing @entity1017 , WAZ changes, and weight and height velocity, whereas @entity6329 CRL 431 modestly improved weight velocity. Independent from probiotics supplementation, regular milk @entity460 did not affect growth or @entity68 and @entity219 status.

title: Probiotics @entity6374 DSM 17938 and @entity6329 XXXX CRL 431 modestly increase growth, but not @entity68 and @entity219 status, among Indonesian @entity1 aged 1-6 years.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity6329 :: ('1582', 'Species') :: ['Casei', 'L. casei', 'Lactobacillus', 'casei']

entities_list: @entity6374 :: ('1598', 'Species') :: ['Lactobacillus reuteri', 'L. reuteri', 'reuteri']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['intestinal infection']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity6329 :: (1582,Species) :: ['casei']


abstract: One of the most important objects of @entity64 rehabilitation is motor recovery from acute stage to chronic stage. Reorganization theory of motor circuits in the cerebral cortex contributing to recovery following @entity64 is proposed. In acute stage motor recovery depends on residual corticospinal tract @entity2146 from onset to 3 months (1(st) stage recovery) . In next stage alternative output system is used according to intracortical @entity2146 depending on intracortical disinhibition at the peak of 3 months (2(nd) stage recovery) . At 6 months and beyond training-induced synaptic strengthening becomes better established, and new networks are better reorganized (3(rd)stage recovery) . @entity64 rehabilitation programs from acute stage are required depending on this stage theory. With each stage to select and perform the most effective rehabilitation programs are necessary. Two obstruction factors of motor recovery are indicated. One of them is @entity6441 of corticospinal tract. Early @entity6441 of the corticospinal tract that is seen on diffusion weighted MRI was reported. The appearance of @entity6441 at acute stage should be directed to more attention as motor recovery inhibition. Next obstruction factor is development of @entity508 from acute stage. Spastic paresis is subjected over time to immobilization of the paretic body part and chronic disuse of the paretic body part, which are avoidable through early rehabilitation intervention. Recently various interventions were proposed for motor recovery. The combination of repetitive transcranial magnetic stimulation and intensive occupational therapy by @entity6910 (2010) are recommended to recovery hand function at chronic stage as 3(rd) stage recovery.

title: [Fundamental theory and practice in XXXX rehabilitation from acute stage to chronic stage].

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['excitability']

entities_list: @entity6441 :: ('MESH:D014855', 'Disease') :: ['Wallerian degeneration']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']