abstract: UNASSIGNED: The aim of the present study was to identify the optimal Ki-67 cut-off value in @entity0 ( @entity0 ) @entity1 , and investigate the association of Ki-67 expression levels with other prognostic factors. Firstly, a retrospective search was performed to identify @entity1 with stage I-III @entity0 (n=462). A range of Ki-67 index values were then assigned to five groups (<10, 10-14, 15-19, 20-24 and >= 25%). The correlation between the Ki-67 index and other prognostic factors [age, @entity5 type, histological and nuclear grade, @entity5 size, multifocality, an in situ component, lymphovascular invasion (LVI), @entity172 and @entity1420 receptor (ER/PR) expression, @entity1 @entity470 ( @entity1722 ) status, axillary involvement and @entity5 stage] were investigated in each group. The median Ki-67 value was revealed to be 20% (range, 1-95%). A young age ( <=40 years old), @entity5 type, size and grade, LVI, ER/PR negativity and @entity1722 positivity were revealed to be associated with the Ki-67 level. Furthermore, Ki-67 was demonstrated to be negatively correlated with ER/PR expression (P<0.001), but positively correlated with @entity5 size (P<0.001). The multivariate analysis revealed that a Ki-67 value of >= 15% was associated with the largest number of poor prognostic factors (P=0.036). In addition, a Ki-67 value of >= 15% was identified to be statistically significant in association with certain luminal subtypes. The rate of disease-free survival was higher in @entity1 with luminal A subtype @entity0 (P=0.036). Following the correlation analysis for the Ki-67 index and the other prognostic factors, a Ki-67 value of >= 15% was revealed to be the optimal cut-off level for @entity0 @entity1 .

title: Clinical and histopathological factors associated with Ki-67 expression in XXXX @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: The present study was designed to investigate whether the clinical or pathologic features of @entity263 ( @entity263 ) are related to the number of repeat biopsies required to establish the diagnosis of @entity263 . METHODS: Between February 1993 and August 2000, 653 @entity1 were evaluated in this retrospective study. All @entity1 underwent transrectal ultrasound-guided biopsy of the prostate prior to radical retropubic prostatectomy. The pathologic findings of specimens obtained at radical prostatectomy and pelvic lymph node dissection as well as PSA levels, findings on DRE, prostate volumes, transition zone volumes, and age were analyzed separately for all @entity263 @entity1 diagnosed at the first set of biopsies (group A) and compared with the data of those diagnosed at the 2nd-5th set of biopsies (group B). In a second step, we compared the results obtained from @entity1 diagnosed at the 2nd set of biopsies (group B1) with those of @entity1 diagnosed at the 3rd to 5th set of biopsies (group B2). RESULTS: Gleason scores, pathologic @entity5 stages, and @entity5 volumes in group B were found to be significantly decreased compared to group A. But from the 2nd to 5th serial biopsy no further decrease in pathologic stage, Gleason score, or @entity5 volume was observed. On the contrary, there was a tendency towards higher @entity5 stages and Gleason scores. Of the @entity5 detected after the second false-negative set of biopsies almost 70% were lesions with Gleason scores of 6 or higher. CONCLUSIONS: False-negative results at the first needle biopsy are predictive of a lower pathologic stage and grade as well as smaller @entity5 volumes of @entity263 diagnosed at repeat sets of biopsies. False-negative results on repeat biopsy, however, have no prognostic significance for the @entity5 stage of PCas detected at subsequent sets of biopsies.

title: Clinical and pathologic features of XXXX detected after repeat false-negative biopsy in a screening population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PCa']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: PURPOSE: In @entity796 @entity5517 , T-helper cell 1-responsive @entity19 strains are susceptible (the @entity267 perforates), and neutralization of @entity60 before @entity281 has been shown to delay the onset of perforation. @entity60 is the predominant cytokine induced by IL-12, and positive regulation of IL-12 by @entity60 , if unchecked, leads to excessive cytokine production and @entity137 . Despite its potential importance, the role of IL-12 in @entity5517 with @entity796 remains unexplored and was the purpose of this study. METHODS: IL-12 knockout @entity19 , histopathology, @entity138 /PCR and ELISA analyses, immunocytochemistry, and quantitation of viable bacteria in @entity267 were used to examine the role of IL-12 in @entity60 production and the susceptibility phenotype. RESULTS: To directly test the effect of IL-12 on @entity60 production, IL-12 knockout and wild-type C57BL/6 @entity19 were used. Both groups of @entity19 were susceptible to @entity281 , with corneal perforation seen at 5 to 7 days after @entity281 . @entity138 -PCR and ELISA analyses confirmed that IL-12 message and protein levels were elevated after @entity281 only in the wild-type @entity19 @entity267 . Other differences between the two groups were detected. Knockout versus wild-type @entity19 showed a significant decrease in @entity60 mRNA levels in the @entity267 and cervical lymph nodes and decreased @entity637 protein levels in @entity267 . Corneas of knockout @entity19 also had a significant increase in bacterial load at 5 days after @entity281 when compared with wild-type @entity19 . CONCLUSIONS: These data provide evidence that IL-12 is important in @entity60 production and in the absence of the cytokine, both @entity60 and @entity637 levels in @entity267 are significantly decreased, resulting in unchecked bacterial growth and perforation.

title: Role of IL-12 and @entity60 in XXXX @entity281 .

entities_list: @entity5517 :: ('MESH:D015817', 'Disease') :: ['ocular infection']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P. aeruginosa']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity796 :: (287,Species) :: ['Pseudomonas aeruginosa']


abstract: The frequency, intensity and velocity of antral contractions were measured by ultrasonography in 32 @entity1 with @entity1723 and in 12 controls before and up to 60 min after a test breakfast. The examination showed that motility was lower in the @entity4148 than in those without and in the non-diabetic controls. The frequency of contractions was determined in the 3 groups as follows: 3.6 +/- 2.0 vs. 4.8 +/- 1.7 vs. 4.8 +/- 1.6 contractions per 2 min (p less than 0.0025); the intensity of contractions was 30.9 +/- 8.2 vs. 41.4 +/- 5.2 vs. 57.5 +/- 8. @entity52053 % of antral area (p less than 0.025, resp. p less than 0.0005); the velocity of contractions was 4.8 +/- 1.5 vs. 8.2 +/- 1.2 vs. 9.95 + 2. @entity52053 % of antral area/sec (p less than 0.0125 resp. p less than 0.005). There was a significant difference in the intensity and velocity of contractions between the @entity1 without @entity4148 and the non-diabetic controls (p less than 0.0025 resp. p less than 0.025). 10 min after the test breakfast the motility indices reached a maximum and then decreased continuously towards the end of the test period (p less than 0.01). 20 min after the test meal this decrease was significantly faster in the @entity1 with @entity4148 than in those without and in controls. In all the diabetics the velocity was positively correlated to the coefficient of the variation from beat to beat of the heart, and also positively correlated to the increase of blood @entity413 concentrations (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Sonographic examination of gastric motility in XXXX .

entities_list: @entity52053 :: ('8 delta', 'DNAMutation') :: ['8 delta']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['insulin-dependent diabetes mellitus']

entities_list: @entity4148 :: ('MESH:D001342', 'Disease') :: ['diabetics with autonomic neuropathy', 'autonomic neuropathy']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity4148 :: (MESH:D001342,Disease) :: ['diabetics with autonomic neuropathy']


abstract: BACKGROUND. Silent peptic @entity1066 has been considered to be associated with @entity32 ( @entity32 ). The recent studies have reported no relationship between them. AIM. We attempted to investigate an association between asymptomatic peptic @entity1066 and @entity32 in Korean adults. METHODS. The subjects were enrolled from @entity1 visiting Myongji Hospital for health examination program of the Korean National Health Insurance Corporation. The questionnaires were designed to investigate individual medical information and @entity1109 . RESULTS. From May 2005 to March 2009, 5459 @entity1 were enrolled and 299 @entity1 were excluded. Of 5160 @entity1 , 3144 (60.9%) @entity1 were asymptomatic and 424 (8.2%) @entity1 had peptic @entity1066 . Among 3144 asymptomatic @entity1 , @entity32 -taking @entity1 had the odds ratio of 1.4 [95% confidence interval (CI): 0.7-2.6, p = 0.339] for the risk of peptic @entity1066 . Among 424 peptic @entity1066 @entity1 , 247 (58.3%) were asymptomatic. They had lower prevalence of @entity32 use (4.9% vs. 14.7%). The asymptomatic @entity2275 @entity1 had smaller size and more frequent healing stage than the symptomatic @entity2275 @entity1 . In multivariable analysis of 424 peptic @entity1066 @entity1 , @entity32 @entity1 had the odds ratio of 0.249 (95%CI: 0.115-0.536, p < 0.05) for asymptomatic peptic @entity1066 . In subgroup analysis of 284 @entity2275 @entity1 , @entity32 -taking @entity1 had the odds ratio of 0.263 (95% CI: 0.105-0.657, p = 0.004) for asymptomatic peptic @entity1066 . CONCLUSION. @entity32 has an inverse association with asymptomatic @entity1 with @entity2275 , but has no association with @entity1109 in duodenal @entity1066 @entity1 . These suggest that @entity32 may be associated with @entity1109 rather than masking symptoms, at least in @entity2275 @entity1 .

title: XXXX is inversely associated with asymptomatic @entity2275 : local health examination data from the Korean National Health Insurance Corporation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['NSAID', 'nonsteroidal anti-inflammatory drug']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['gastroduodenal symptoms']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer', 'gastric peptic ulcer']

answer: @entity32 :: (MESH:D007249,Disease) :: ['NSAID']


abstract: The literature data were surveyed to clarify the role of @entity1760 and @entity972 in the development of @entity731 ( @entity731 ) in @entity291 and the findings were compared with @entity1 data. Special attention was paid to the eastern Finland where @entity731 is very common in @entity1 and absent in the @entity291 . A hypothesis is proposed that high @entity1760 and @entity972 intakes at plant feeding protect from severe @entity731 processes at least in @entity291 in the absence of @entity281 . In about 1500 necropsies in @entity291 and @entity291 on plant feeding, neither antemortem clinical @entity731 symptoms nor postmortal macroscopical @entity731 were detected in the endocardium or in aorta. Also, abattoiries in endemic @entity4259 - and @entity270 -deficient areas report that no macroscopic @entity731 have been found in the inspected more than 400000 slaughtered @entity291 . In @entity3875 poisoned @entity291 @entity731 is readily detected. The milk-fed @entity291 in @entity1760 deficiency experiments regularly show @entity731 after 3 months of age. Adult ruminating @entity291 get daily 150-300 g @entity972 while the need @entity3482 g. During the indoor feeding period the @entity291 suffered in eastern Finland often from carotene, @entity270 and @entity4259 deficiencies as well as also of energy, protein, @entity3151 and @entity219 deficiencies before grass ensiling feeding started. @entity4759 was about 30%. Still such @entity291 did not have @entity731 under such unfavorable conditions. The findings support the hypothesis that the high @entity1760 and @entity972 intakes protect @entity291 from @entity731 .

title: Does high plant feed XXXX and @entity972 protect healthy ruminants from @entity731 ? A review.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'humans']

entities_list: @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E']

entities_list: @entity4259 :: ('MESH:D012643', 'Chemical') :: ['selenium']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['chronic infections']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'AS']

entities_list: @entity291 :: ('9913', 'Species') :: ['cows', 'cattle', 'calves']

entities_list: @entity4759 :: ('MESH:D006043', 'Disease') :: ['Endemic goiter prevalence']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity1760 :: (MESH:D008274,Chemical) :: ['magnesium']


abstract: OBJECTIVES: This study aimed to compare autologous bone (AB), @entity291 bone (BB), and @entity1641 bone (EB) blocks with regard to de novo bone formation, connective tissue, and residual bone substitute material portions in a standardized defect animal model. MATERIAL AND METHODS: In the frontal skull of 20 @entity1707 , 106 standardized cylindrical "critical size defects" were prepared. Defects were randomly filled with AB, BB, and EB blocks. After a healing period of 30 and 60 days, de novo bone formation, residual bone substitute material, and connective tissue portion was assessed by means of histomorphometry ( @entity11979 staining). Mann-Whitney U-tests were used to evaluate differences between the groups. RESULTS: The de novo bone formation was significantly higher in the AB group in comparison to the xenogeneic groups (p  <  0.05). After 30 days, EB showed significantly (p  <  0.05) more newly formed bone compared to the BB group. The soft tissue formation was significantly higher in the BB and EB group. Defects augmented with BB showed significantly (p  <  0.05) higher portions of bone substitute materials compared to sides augmented with EB after 30 days. CONCLUSION: In the extra-oral model, @entity79 were superior concerning de novo bone formation. No clinical advantages of EB blocks could be observed.

title: Extra-oral defect augmentation using autologous, @entity291 and XXXX bone blocks: A preclinical histomorphometrical comparative study.

entities_list: @entity11979 :: ('MESH:D014048', 'Chemical') :: ['Toluidine blue O']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['AB blocks']

answer: @entity1641 :: (9796,Species) :: ['equine']


abstract: INTRODUCTION: @entity740 ( @entity740 ) remains a prevalent public health problem that disproportionately affects minorities and the poor, despite intense efforts targeting traditional risk factors. @entity2520 are common bacterial plaque-induced inflammatory conditions that can respond to treatment and have been implicated as a @entity740 risk factor. However there is limited evidence that treatment of @entity2520 slows the progression of @entity740 . METHODS/DESIGN: We describe the protocol of the Kidney and @entity2520 (KAPD) study, a 12-month un-blinded, randomized, controlled pilot trial with two intent-to-treat treatment arms: 1. immediate intensive non-surgical periodontal treatment or 2. rescue treatment with delayed intensive treatment. The goals of this pilot study are to test the feasibility of conducting a larger trial in an ethnically and racially diverse, underserved population (mostly poor and/or low literacy) with both @entity740 and significant @entity2520 to determine the effect of intensive periodontal treatment on renal and inflammatory biomarkers over a 12-month period. RESULTS: To date, KAPD has identified 634 potentially eligible @entity1 who were invited to in- @entity1 screening. Of the 83 (13.1%) of potentially eligible @entity1 who attended in- @entity1 screening, 51 (61.4%) were eligible for participation and 46 enrolled in the study. The mean age of @entity1 is 59.2years (range 34 to 73). Twenty of the @entity1 (43.5%) are Black and 22 (47.8%) are Hispanic. DISCUSSION: Results from the KAPD study will provide needed preliminary evidence of the effectiveness of non-surgical periodontal treatment to slow @entity740 progression and inform the design future clinical research trials.

title: The Kidney and XXXX (KAPD) study: A pilot randomized controlled trial testing the effect of non-surgical periodontal therapy on @entity740 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'person']

entities_list: @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease', 'Periodontal diseases', 'Periodontal Disease']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD']

answer: @entity2520 :: (MESH:D010510,Disease) :: ['Periodontal Disease']


abstract: BACKGROUND: To identify potential molecular prognostic markers in @entity16867 ( @entity16867 ) @entity3052 , we analyzed incidences and prognostic impacts of mutations in @entity2467 , @entity8587 , @entity6863 , @entity5315 , and a number of epigenetic genes in @entity16867 @entity3052 . METHODS: Seventy one and 21 @entity3052 @entity1 with t(8;21) and inv(16) were enrolled in this study, respectively. @entity8102 , @entity6863 , @entity2467 , @entity8725 , @entity15786 , @entity16719 , @entity8587 , and @entity5315 mutations were analyzed by direct sequencing. @entity1 were categorized with respect to @entity2467 and @entity8587 mutation status, and both clinical features and prognoses were compared. RESULTS: The incidences of @entity7801 internal tandem duplication (ITD), @entity8102 , @entity6863 , @entity8725 , @entity15786 , @entity16719 , and @entity5315 mutations were low ( <=5%) in @entity16867 @entity3052 @entity1 . However, @entity2467 and @entity8587 mutations occurred frequently (10.9% and 13.8%, respectively). t(8;21) @entity1 with @entity2467 mutations showed significantly shorter overall survival (OS) and disease free survival (DFS) periods than those without mutations (P<0.001, for both); however, although the limited number of t(8;21) @entity1 were analyzed, @entity8587 mutation status did not affect prognosis significantly. Relapse or @entity204 during follow-up occurred more frequently in t(8;21) @entity1 carrying @entity2467 mutations than in those without the mutation, although the difference was significant only in a specific @entity1 subgroup with no @entity8587 mutations (P=0.014). CONCLUSIONS: The incidences of mutations in epigenetic genes are very low in @entity16867 @entity3052 ; however, @entity2467 and @entity8587 mutations occur more frequently than others. The poor prognostic impact of @entity2467 mutation in t(8;21) @entity3052 @entity1 only applies in a specific @entity1 subgroup without @entity8587 mutations. The prognostic impact of @entity8587 mutation in @entity16867 @entity3052 is not evident and further investigation is required.

title: Incidences and Prognostic Impact of @entity2467 , XXXX , @entity6863 , and @entity5315 Mutations, and Mutations Associated With Epigenetic Modification in @entity16867 Acute Myeloid Leukemia: A Multicenter Study in a Korean Population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients', 'patient']

entities_list: @entity16867 :: ('10153', 'Gene') :: ['core binding factor', 'CBF']

answer: @entity8587 :: (7490,Gene) :: ['WT1']


abstract: The FT-Raman quantification of @entity3522 and @entity3416 commercial injection solutions was performed. The efficiency of various spectra treatment procedures including classical univariate intensity ratio and multivariate @entity1625 ( @entity1625 ) and principal component regression (PCR) methods was compared. First, the calibration models were built using unnormalised spectra. Next, spectra normalised by the intensity of a selected band of @entity15544 added as an internal standard to the studied samples were utilised. To compare the predictive ability of the models constructed, the relative standard error of prediction (RSEP) was calculated. The errors found for multivariate calibrations were a few times smaller than those for the univariate ones. Usually, the most effective was the @entity1625 method, for which RSEP values of the order of 1-2% for calibration and 2-3% for testing data sets were obtained. Four commercial preparations of @entity3522 and one of @entity3416 containing by weight, 2.4% of the active pharmaceutical ingredient (API) were quantified applying the developed models. Concentrations found from the Raman data analysis correlate with the declared values and the results of reference analyses. For the studied @entity3522 solutions they amount to 99.2-101.2% of the former and 101.2-102.4% of the latter quantities for the @entity1625 models optimised for each medicine based on unnormalised spectra. These values for the @entity3416 preparation were found to be 101.0 and 99.1%, respectively. It shows that the proposed procedure based on the chemometric treatment of FT-Raman spectra can be a fast and convenient alternative to the standard pharmacopoeial procedures of API quantification even in relatively diluted injection solutions.

title: Quantitative determination of XXXX and @entity3416 in injection solutions by FT-Raman spectroscopy.

entities_list: @entity1625 :: ('MESH:D004828', 'Disease') :: ['partial least squares', 'PLS']

entities_list: @entity3416 :: ('MESH:D000628', 'Chemical') :: ['aminophylline']

entities_list: @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac sodium']

answer: @entity3522 :: (MESH:D004008,Chemical) :: ['diclofenac sodium']


abstract: We report a case of @entity292 caused by @entity2275 , a very rare condition. The @entity1 was an 81-year-old- @entity1 who had had multiple recurrences of @entity2275 . She also had @entity6 . She was admitted to our hospital because of a left femoral @entity174 , necessitating a mechanical bone head exchange operation. She had severe @entity490 and @entity417 on the 48th postoperative day. Gastroendoscopic examination revealed a giant ulcer with a long-axis diameter of more than 5cm on the lesser curvature of the gastric body. She was treated with intravenous @entity6359 and all oral intake was restricted; her symptoms were alleviated. Two weeks later, a @entity292 had formed between the stomach and the jejunum just anal to the duodeno-jejunal flexure. She was placed on an ulcer diet, and was discharged with no symptoms on the 151st postoperative day. She has remained asymptomatic for 1 1/2, years to date. Lack of H2-antagonist administration, operative stress, and administration of @entity4260 appeared to have induced @entity2275 recurrence, and formation of the @entity292 between the stomach and the jejunum seemed to have been facilitated by the @entity1 being very lean and having minimal mesenteric adipose tissue.

title: @entity292 caused by XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity6359 :: ('MESH:D015738', 'Chemical') :: ['famotidine']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['head fracture']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['fistula', 'gastrojejunal fistula']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity4260 :: ('MESH:C018986', 'Chemical') :: ['ipriflavone']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer', 'benign gastric ulcer']

answer: @entity2275 :: (MESH:D013276,Disease) :: ['gastric ulcer']


abstract: OBJECTIVE: The practice of using fenestrated endografts to treat juxtarenal and group IV @entity2334 ( @entity2334 ) has become more accepted, but long-term outcomes are still unknown. We report long-term survival, complications, and branch-related outcomes from a single-center experience. METHODS: The study included consecutive @entity1 enrolled prospectively into a physician-sponsored investigational device exemption classified as undergoing group IV TAAA or @entity439 repair by the treating surgeon using fenestrated endografts. Device morphology was used to subclassify this group of @entity1 . Long-term survival and a composite outcome of secondary intervention, branch occlusion, stent migration, endoleak, @entity439 growth, or @entity1566 were calculated. Descriptive analysis of branch-related outcomes and need for any reintervention was performed. Univariate and multivariate analysis of mortality and the composite outcome was performed to determine associative risks. RESULTS: Long-term survival for @entity1 with juxtarenal and group IV TAAA @entity439 treated with fenestrated stent grafts was 20% at 8  years. Multivariate analysis showed long-term survival for this @entity1 population was negatively associated with increasing age, @entity712 , @entity5 , and previous @entity439 repair. The risk of @entity2759 ( @entity2759 ) in this group was 1.2% and of aortic-related mortality was 2%. The risk of a spinal event increased with coverage above the celiac artery (52  mm of coverage above the celiac artery in @entity1 with @entity2759 vs 33  mm without @entity2759 ; P  = .099). More complex device configurations were more likely to require an increased rate of reinterventions, and @entity1 with celiac fenestrations were more likely to experience celiac occlusion over time (3.5% vs 0.5%; P  = .019). However, less complex designs were complicated by an increased risk of type I endoleak over time (10.4% for renal fenestrations only vs 1.9% for others; P  < .01). As experience evolved, there was a trend to increase the number of fenestrations in devices treating the same anatomy. CONCLUSIONS: The use of fenestrated devices to treat juxtarenal and group IV TAAA is safe and effective in long-term follow-up. Mortality in this @entity1 population is largely not aortic-related. Devices designed for fenestrated repair of juxtarenal and group IV thoracoabdominal @entity439 within a physician sponsored investigational device exemption have changed over time. Further research is needed to determine the best configuration to treat @entity439 requiring coverage proximal to the celiac artery.

title: Twelve-year results of fenestrated endografts for juxtarenal and group IV thoracoabdominal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2334 :: ('MESH:D017545', 'Disease') :: ['thoracoabdominal aortic aneurysms', 'TAAAs']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'juxtarenal aneurysm', 'aneurysm']

entities_list: @entity2759 :: ('MESH:D020760', 'Disease') :: ['SCI', 'spinal cord ischemia']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysms']


abstract: The modified Fontan procedure is being used in an increasing number of complex cyanotic @entity299 with @entity849 . Seven @entity1 aged 11 to 24 years (average 17.5 years) underwent surgery by a technique derived from the Fontan procedure: direct atriopulmonary @entity254 without a tube or valve. The tricuspid valve when patent was closed with a patch. The diagnoses were: single ventricule (4 cases), @entity1147 (2 cases) and @entity1145 (1 case). All @entity1 had associated @entity849 with @entity358 . The great vessels were in L-malposition in 3 cases. The hospital mortality was nil. Transient @entity955 was observed in 2 cases and was well tolerated clinically. The follow-up period ranges from 2 months to 4 years (average 2.3 years). All @entity1 are acyanotic with no signs of right-sided failure and in sinus rhythm. Control cardiac catheterisation and angiography were performed in 6 cases and showed good function of the @entity254 and a mean atrial pressure of 14 mmHg. Direct atriopulmonary @entity254 offers a very acceptable surgical solution to certain forms of single ventricle or equivalent with low pulmonary pressures. The short and medium term results seem to be better than those of intraventricular repair.

title: [Direct atriopulmonary XXXX (modified Fontan) for single ventricle and its equivalents].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1145 :: ('MESH:D018785', 'Disease') :: ['tricuspid atresia']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['pulmonary stenosis']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['low pulmonary vascular resistances']

entities_list: @entity1147 :: ('MESH:D004310', 'Disease') :: ['Taussig-Bing anomaly']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac lesions']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: The pituitary gonadotrophins LH and FSH are responsible for regulation of gametogenesis in the testis and ovary. Chorionic gonadotrophin (CG), a third closely related glycoprotein hormone derived by gene duplication of the @entity6753 gene and secreted by the placenta in primates, is essential for the rescue of the corpus luteum and maintenance of pregnancy. We have recently shown that marmoset (m) @entity62232 mRNA is highly expressed in the pituitary of the @entity7533 ( @entity7533 ) and that LH is less active than @entity1 CG in activating the @entity1 @entity10548 lacking exon 10. To investigate further which gonadotrophin is the actual ligand of the @entity10548 (LHR) of the marmoset monkey that naturally lacks exon 10, we identified and characterised the genomic organisation of the @entity12102 gene and its expression. Intergenic PCR amplification of the region encompassing the @entity12102 and the @entity44828 genes revealed that, surprisingly, @entity44828 is located 20 kbp upstream of the @entity6753 gene, whereas in other species the intergenic distance is approximately 2-3 kbp. Sequence analysis of the @entity12102 coding region showed 70% identity to @entity44828 and 90% identity to @entity1 @entity6753 at the @entity535 level. Both gonadotrophin beta subunits are present at the genomic level, but RT-PCR of pituitary and placental total RNA using specific oligonucleotides for @entity44828 and @entity12102 showed high expression of @entity44828 mRNA in both tissues, whereas @entity6753 was expressed neither in the pituitary nor in the placenta. Thus @entity12102 mRNA is lacking in the marmoset pituitary. Immunohistochemistry of marmoset pituitaries showed that mCG was confined to the gonadotrophes, and partly co-localised in cells stained positively for FSH. Western blot analysis confirmed the presence of mCG in the pituitary. Northern blot analysis using @entity44828 as a probe displayed one transcript of 0.7 kb in the pituitary and detected two transcripts of 1.1 kb and 2 kb in the marmoset placenta. Our results suggest that, in the @entity7533 , CG is the only gonadotrophin with luteinising function that is present in the pituitary. We postulate that, owing to an unknown mutational event in evolution, expression of mLH was completely abolished, and CG - which, unlike LH, acts normally even when exon 10 is missing from the LHR - took over its function.

title: Chorionic gonadotrophin beta subunit mRNA but not luteinising hormone beta subunit mRNA is expressed in the pituitary of the @entity7533 ( XXXX ).

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity7533 :: ('9483', 'Species') :: ['Callithrix jacchus', 'common marmoset']

answer: @entity7533 :: (9483,Species) :: ['Callithrix jacchus']


abstract: In order to examine neurological outcome in twins, a multi-centre prospective cohort study of @entity1 was used. @entity1 entered at the first prenatal visit, with follow-up of offspring to the age of 7 years. Outcome measures were @entity204 , @entity306 , @entity410 disorders including neonatal, febrile or nonfebrile, and intelligence quotient. Among a total of 52,364 livebirths, there were 1079 twins. Overall, rates of fetal or @entity204 and @entity306 were higher in twins. Neonatal and @entity410 occurred with similar frequency in twins as in singletons. Although twins were much more likely than singletons to be low in birthweight, twins < 2500 g were not at higher risk for @entity306 than low birthweight singletons. The risk of @entity306 and of @entity302 was similar in monozygous and dizygous pairs, and in like-sex and unlike-sex pairs. Death of one twin was associated with higher rates of @entity306 and of @entity302 in survivors, but not with lowered intelligence. Data from this cohort suggest that low birthweight and survival status of the co-twin are dominant predictors of childhood @entity16 in twins.

title: Childhood XXXX in twins.

entities_list: @entity1 :: ('9606', 'Species') :: ['Women', 'infants']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'febrile seizures']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological morbidity']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['nonfebrile seizure disorders']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death', 'death']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity16 :: (MESH:D009422,Disease) :: ['neurological disorders']


abstract: @entity15539 is a waterborne @entity15539 that commonly infects fish and amphibians worldwide, but transmission to @entity1 can occasionally occur, typically as a granulomatous @entity272 following minor hand @entity130 . Infection involving the lungs is very rare. We herein describe a case of @entity15539 -associated @entity55 and pneumothorax. In August 2008, an 81-year-old @entity1 was admitted to a hospital for detailed examination of @entity353 and an abnormal shadow on chest imaging. Based on a sputum test, nontuberculous @entity4593 caused by @entity15539 was diagnosed. At that time, the blood chemistry revealed no respiratory symptoms or inflammatory findings, and the @entity1 was treated on an outpatient basis with @entity2929 and an expectorant. In late November 2008, sputum and coughing were observed. Furthermore, the @entity1 developed a @entity221 and @entity662 that increased while breathing and he visited the emergency outpatient unit of our hospital on December 1. @entity519 , @entity55 , and right pneumothorax were observed, and a chest tube was inserted into the right thoracic cavity. Results of an acid-fast bacteria smear from the sputum and @entity1143 were positive, and @entity15539 was identified on culture. The @entity1 was diagnosed as having a @entity358 complicated by pneumothorax caused by @entity15539 . The @entity358 was ameliorated with @entity4581 , @entity1215 and @entity3110 . However, no decreased in the air leaking from the chest tube was noted and inflation of the lung was incomplete. The department of respiratory surgery therefore performed thoracoplasty and lung cerclage. Subsequently, the air leak subsided, allowing removal of the chest tube and the @entity1 was discharged.

title: [A case of XXXX complicated by pneumothorax caused by @entity15539 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patient', 'man']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion']

entities_list: @entity3110 :: ('MESH:D004977', 'Chemical') :: ['ethambutol']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia', 'bilateral pneumonia']

entities_list: @entity4581 :: ('MESH:D017291', 'Chemical') :: ['clarithromycin']

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity4593 :: ('MESH:D009165', 'Disease') :: ['mycobacteriosis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infection']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxemia']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung infection']

entities_list: @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']

entities_list: @entity15539 :: ('1781', 'Species') :: ['M. marinum', 'mycobacterium', 'Mycobacterium marinum']

answer: @entity358 :: (MESH:D008171,Disease) :: ['lung infection']


abstract: Severe @entity311 by @entity3964 is a potentially fatal disease, frequently unresponsive to even the most aggressive treatments. Host organ failure is associated with acquired @entity2003 red blood cells and capillary blockage. In vitro techniques have played an important role in modeling cell deformability. Although, historically they have either been applied to bulk cell populations or to measure single physical parameters of individual cells. In this article, we demonstrate the unique abilities and benefits of elastomeric microchannels to characterize complex behaviors of single cells, under flow, in multicellular capillary blockages. Channels of 8-, 6-, 4-, and 2-microm widths were readily traversed by the 8 microm-wide, highly elastic, uninfected red blood cells, as well as by infected cells in the early ring stages. Trophozoite stages failed to freely traverse 2- to 4-microm channels; some that passed through the 4-microm channels emerged from constricted space with deformations whose shape-recovery could be observed in real time. In 2-microm channels, trophozoites mimicked "pitting," a normal process in the body where @entity6227 without destroying the red cell. Schizont forms failed to traverse even 6-microm channels and rapidly formed a capillary blockage. Interestingly, individual uninfected red blood cells readily squeezed through the blockages formed by immobile schizonts in a 6-microm capillary. The last observation can explain the high @entity5895 in a growing capillary blockage and the well known benefits of early blood transfusion in severe @entity311 .

title: A microfluidic model for single-cell capillary obstruction by XXXX -infected erythrocytes.

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigidity of infected']

entities_list: @entity6227 :: ('MESH:D003668', 'Disease') :: ['spleen beds remove parasites']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemia']

entities_list: @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum']

answer: @entity3964 :: (5833,Species) :: ['Plasmodium falciparum']


abstract: OBJECTIVE: To investigate the prevalence and course of pass notive shoulder range of motion in @entity1 with a @entity1566 and the relationships between shoulder range of motion limitations and personal and lesion characteristics. DESIGN: Multicentre longitudinal study. SUBJECTS: A total of 199 subjects with @entity1566 admitted to specialized rehabilitation centres. METHODS: Assessments of shoulder range of motion at the start of active rehabilitation, 3 months later, at discharge and one year after discharge. RESULTS: Up to 70% (95% confidence interval (CI): 57-81) of the subjects with @entity1688 and 29% (95% CI: 20-38) of those with @entity451 experienced a limited range of motion of the shoulder during, or in the first year after, inpatient rehabilitation. Shoulder flexion was affected most. Up to 26% (95% CI: 20-37) of subjects had a shoulder range of motion limitation on both sides. Increased age, @entity1688 , @entity508 and longer duration between injury and start of active rehabilitation increased the risk. Presence of shoulder @entity158 is associated with limited shoulder range of motion. CONCLUSION: Limited shoulder range of motion is common following @entity1566 . @entity1688 , increased age, @entity508 , longer duration between injury and start of active rehabilitation and shoulder @entity158 are associated with an increased risk for shoulder range of motion problems and require extra attention.

title: Passive shoulder range of motion impairment in XXXX during and one year after rehabilitation.

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['Tetraplegia', 'tetraplegia']

entities_list: @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity of elbow extensors']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['paraplegia']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: We show here that @entity17192 ( @entity17192 ) is involved in patterning the developing @entity1573 limb. During early stages of limb development, mesenchymal expression of the @entity17192 gene is restricted to the posterior part of the bud, in a domain that colocalizes with the polarizing region. The polarizing region is a group of cells at the posterior margin of the limb bud that can respecify the anteroposterior axis of the limb when grafted anteriorly and can activate expression of genes of the HoxD complex. We dissect possible roles of @entity17192 in the polarizing region signalling pathway by manipulating the developing wing bud. @entity1968 application, which mimics the effects of polarizing region grafts, activates @entity17192 gene expression in anterior cells. This shows that changes in anteroposterior pattern are correlated with changes in @entity17192 expression. When polarizing region grafts are placed at the anterior margin of the wing bud, the grafts continue to express the @entity17192 gene and also activate @entity17192 expression in the adjacent anterior host mesenchyme. These data suggest that @entity17192 is part of the response pathway to the polarizing signal, rather than being the signal itself. In support of this, @entity17192 protein does not appear to have any detectable polarizing activity when applied to the wing bud. The pattern of @entity2089 gene expression in the developing wing bud raises the possibility that @entity17192 and @entity2089 could act in concert. There is a close relationship, both temporal and spatial, between the activation of the @entity17192 and @entity42452 genes in response to @entity1968 and polarizing region grafts, suggesting that expression of the two genes might be linked.

title: Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing XXXX limb.

entities_list: @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid', 'Retinoic acid']

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: BACKGROUND: @entity8 can reduce renal reserve and lead to @entity177 and failure. Angiomyolipomata often have abnormal vasculature, with @entity439 that can @entity548 . Treatment of angiomyolipomata greater than 4 cm in diameter is suggested to decrease the risk for @entity548 . Nephron-sparing procedures are critical in @entity1 because of their limited renal reserve. Embolization has been used to treat these @entity5 , but there are limited studies examining efficacy. Our study examines the efficacy of selective embolization in decreasing @entity5 burden, preventing @entity548 , and preserving renal function. METHODS: We conducted a retrospective study of 16 @entity1 with 20 angiomyolipomata on 18 kidneys who underwent 18 transcatheter transarterial embolization procedures. @entity439 and size were documented and @entity5 volumes were measured before and after embolization. Preprocedure and follow-up renal function also were measured. Changes in @entity359 volume and kidney function were assessed for significance by using paired t-test. RESULTS: Before embolization, 7 angiomyolipomata had more than 5 @entity439 , 9 had 1 to 5 @entity439 , and 4 had no @entity439 , but showed tortuous dysmorphic arteries. Mean @entity439 size was 5 mm. In @entity1 available for follow-up, 15 of 16 @entity5 had decreased in volume (mean decrease, 56.1%; P = 0.001). At an average of 40 months' follow-up, there have been no subsequent @entity548 . @entity1 ' decline in renal function was not significantly different from that expected because of the natural course of the disease. CONCLUSION: Selective embolization decreases @entity5 size, prevents @entity548 , and preserves kidney function in @entity1 with @entity2916 with @entity8 .

title: Embolization of @entity8 in @entity1 with XXXX complex.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal angiomyolipomata', 'renal angiomyolipomata']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'hemorrhages']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'Aneurysm number', 'aneurysm']

entities_list: @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis']

entities_list: @entity359 :: ('MESH:D018207', 'Disease') :: ['angiomyolipoma']

answer: @entity2916 :: (MESH:D014402,Disease) :: ['tuberous sclerosis']


abstract: OBJECTIVES: To identify predictors and possible pathogenetic mechanisms of early @entity16 in @entity1 with acute @entity385 and to evaluate their impact on clinical outcome. DESIGN: Case series. SETTING: University hospital's @entity64 unit. @entity1 : A continuous series of 152 @entity1 with first-ever @entity63 hemispheric strokes were hospitalized within 5 hours of onset, evaluated with the Canadian Neurological Scale, and underwent a computed tomographic (CT) scan. The initial subset of 80 @entity1 also underwent angiography. A repeated CT scan or autopsy was performed within 5 to 9 days of a @entity1 's @entity64 . Progressing @entity51 was defined as a decrease of one point or more in the global neurological scale score during hospitalization, when compared with that at entry. RESULTS: The conditions of 39 @entity1 (26%) deteriorated during the initial 4 days; 20 @entity1 (51%) had an impaired level of consciousness, and 19 @entity1 (49%) had impaired limb strength and/or speech. They had been hospitalized earlier and had higher serum @entity413 levels at admission; the baseline CT scans of these @entity1 showed an early focal @entity6152 and initial mass effect more frequently. On the repeated CT scan (144 @entity1 ) or at autopsy (eight @entity1 ), @entity1 with a progressing course more frequently had large @entity1188 , severe mass effect, and @entity385 . We found no differences with regard to demographic data, medical history, and treatments that were given; only subcutaneous heparin @entity460 was more frequently administered to @entity1 with a progressing course. Twenty-two (27%) of the 80 @entity1 who underwent angiography had a progressing course, of whom 20 (91%) had an intracranial and/or extracranial @entity432 , with collateral blood supply in seven @entity1 (35%). Logistic regression analysis showed that the independent predictors of progression were the serum @entity413 levels at admission and the early focal @entity6152 with cortical and corticosubcortical locations, with the positive predictive values of the latter being 34% (95% confidence interval [CI], 26% to 42%) and 57% (95% CI, 47% to 67%), respectively. Among @entity1 who underwent angiography, logistic regression analysis showed a significant correlation between carotid siphon occlusion and a progressing course. The 30-day case-fatality ratio and disability (Barthel index, < 60) were higher in @entity1 with a progressing course (36% and 54% vs 12% and 35%, respectively). CONCLUSIONS: Early @entity64 deterioration is still an event that is difficult to predict; it is largely determined by @entity2657 following an @entity432 , as indicated by an early focal @entity6152 and initial mass effect on the baseline CT scan. Since early deterioration anticipates a bad outcome in 90% of @entity1 , it might be used as an early surrogate end point in therapeutic trials.

title: Progressing @entity51 secondary to acute XXXX . A study on predictability, pathogenesis, and prognosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity2657 :: ('MESH:D001929', 'Disease') :: ['cerebral edema']

entities_list: @entity6152 :: ('MESH:C565408', 'Disease') :: ['hypodensity']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological deterioration']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusion']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['hemorrhagic infarction', 'ischemic strokes']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: Porcine luteal cells were obtained from the corpora lutea on the 13th day of the estrous cycle. The cells were digested with 0.25% trypsin and suspended in the Medium 199 with an addition of 10% calf serum, at a concentration of 5 X 10(4) cells/ml. The cells were incubated with or without 4 and 40 mi.u./ml of @entity398 , 10 and 100 ng/ml of @entity369 - @entity10063 , 1 microgram LH and 50 U/ml hCG. Levels of @entity1420 , @entity251 and @entity53 17 beta were determined with the radioimmunological method, following 6 h incubation. It was found that @entity1420 secretion under the influence of @entity29842 (4 mi.u./ml) was less than in the control group and in the group with LH. Similarly, @entity369 - @entity10063 at a dose of 10 ng/ml inhibited @entity1420 secretion (P less than 0.05). Higher doses of these peptides had no suppressive effect on the luteal cells. @entity398 and @entity369 - @entity10063 had no influence on @entity251 secretion by luteal cells. However, these cells produced less (P less than 0.05) @entity53 17 beta under the influence of @entity29842 than of hCG. The results point to a direct effect of @entity398 and @entity369 - @entity10063 on steroidogenesis in the corpora lutea of cyclic @entity1707 .

title: The effect of XXXX and @entity10063 upon @entity1420 , @entity251 and @entity53 17 beta-secretion by the luteal cells from cyclic @entity1707 .

entities_list: @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin', 'Oxytocin']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity29842 :: ('CHEBI:7872', 'Chemical') :: ['oxytocine']

entities_list: @entity10063 :: ('MESH:D014668', 'Chemical') :: ['vasotocin']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity398 :: (MESH:D010121,Chemical) :: ['oxytocin']


abstract: @entity2628 at a dose of 2 mg b.i.d. has been shown to be an effective aromatase inhibitor in advanced stage @entity0 @entity1 as determined by its ability to significantly suppress endogenous @entity172 biosynthesis over a 12-week period. Continued suppression of circulating @entity172 levels over a prolonged period has not yet been examined in published reports. In this study, we report the extended use of @entity2628 at a maintenance dose of 2 mg b.i.d. in a cohort of 11 @entity1 extending to 973 days of therapy. Results show that the degree of suppression of plasma and urinary @entity172 was maintained in all @entity1 throughout the extended period of drug use. Continued @entity53 suppression of over 50% or greater from baseline was observed, as was continued suppression of @entity1815 to over 80% from baseline. @entity701 determinations after 9 months of treatment showed no suppression from baseline. The @entity1369 values and responses to cortrosyn stimulation continued to be suppressed as first noted following the initial 3 months of the core clinical trial. Objective @entity5 response noted in the core clinical trial did not change until disease progression. These findings suggest that @entity2628 maintains its ability to suppress the aromatase enzyme during long term use. No observable escape from suppression of plasma and urinary @entity172 occurred during prolonged treatment.

title: The effects of long term XXXX treatment in @entity1 with advanced stage @entity0 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens']

entities_list: @entity2628 :: ('MESH:D017316', 'Chemical') :: ['fadrozole hydrochloride', 'Fadrozole hydrochloride']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol']

answer: @entity2628 :: (MESH:D017316,Chemical) :: ['fadrozole hydrochloride']


abstract: PURPOSE: We investigated the effects of @entity42316 on neurite extension of cultured retinal pieces and axonal regeneration of retinal ganglion cells in the crushed optic nerve of adult @entity468 . METHODS: The retinal pieces were cultured with unoprostone or its primary metabolite, M1, dissolved in @entity3733 or @entity6496 for 14 days, and the number and length of Tau-1-positive neurites and glial processes labeled with anti-glial fibrillary acidic protein antibodies were examined. After the optic nerve was crushed, unoprostone was injected into the vitreous body and the crushed site. On day 12, @entity3505 germ agglutinin-conjugated horseradish @entity3698 was injected into the vitreous body to anterogradely label the regenerated axons. On day 14, the optic nerve was excised and longitudinally sectioned. After @entity3698 reaction, the number of axons regenerating beyond the crush site was examined. RESULTS: The greatest number of neurites protruded from the cultured retinal pieces in 3  M unoprostone and 3  M M1. The neurite length was also the longest at 3  M unoprostone and 3  M M1, in which no glial processes were detected. After injections of 3  M unoprostone, the final concentration in the vitreous humor, into the vitreous body and the crush site, the optic nerve fibers regenerated and extended beyond the crush site. In contrast, almost no fibers extended beyond the crush site after injection of @entity1391 -buffered saline. CONCLUSIONS: The results indicate that intravitreal injection of unoprostone promotes regeneration of crushed optic nerve fibers in adult @entity468 .

title: Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult XXXX .

entities_list: @entity6496 :: ('CHEBI:53426', 'Chemical') :: ['polysorbate']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity42316 :: ('CHEBI:39455', 'Chemical') :: ['unoprostone']

answer: @entity468 :: (9685,Species) :: ['cats']


abstract: From the years 1982 to 1989, 377 @entity1 with alpine skiing-related @entity130 were admitted to St. Anthony's Hospital (a level one regional @entity130 center). Fifty femur @entity174 were recorded in 48 @entity1 : 29 femoral shaft @entity174 (2 open), 15 @entity173 , and 6 supracondylar @entity174 (2 open). In the femoral shaft @entity174 group, the predominant @entity174 pattern was a short, transverse, comminuted @entity174 , illustrating the high kinetic energy of the accident. In this group, 11 @entity1 returned to skiing, 7 of whom had hardware in place. Of the 10 Garden @entity2249 , 4 progressed to avascular @entity39 . Three @entity1 required press-fit total hip arthroplasties. Only 4 of these 10 @entity1 returned to skiing. Median injury severity scores were 9.1 in 345 @entity1 (94%), suggesting @entity130 . Collisions with trees or poles accounted for 32% (15 @entity1 ) of all @entity130 . Follow-up data on return to skiing was available on 43 @entity1 and of these 19 (44%) returned to skiing.

title: XXXX in alpine skiers.

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['femoral neck fractures']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'isolated trauma', 'trauma']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Femur fractures']


abstract: OBJECTIVE: Postoperative morbidity after correction of @entity1152 is partly determined by @entity354 , which has been proven to affect from one-half to two-thirds of @entity1 during childhood. We conducted a follow-up study to test our hypothesis that, if former @entity1 still show @entity354 at adult age, they are at high risk for developing @entity355 , which is considered to be premalignant. METHODS: Of 69 @entity1 born between 1971 and 1978, all having undergone a primary @entity254 , 24 had died, five of them because of @entity1173 . Of the 45 survivors, 39 could be traced; they all completed a questionnaire inquiring after symptoms related to the esophagus. Of these @entity1 , 34 underwent an additional esophagogastrocopy. RESULTS: Only nine of the 39 @entity1 had no symptoms at all; 30 had mild to severe @entity1282 symptoms, and 13 had mild to severe @entity304 . Esophagogastrocopy in 34 @entity1 revealed that the @entity254 was still recognizable in all cases, but stenoses were not found. Six @entity1 showed a @entity357 , and one a large one. The incidences of @entity304 (13/39, p < 0.01), @entity354 (9/34, p < 0.01) and @entity355 (2/34, p < 0.001) were significantly higher than in the normal population. CONCLUSIONS: This group seems to be at risk for developing @entity355 . As this is the first follow-up study of a consecutive group of adult @entity1152 @entity1 , we think it is advisable to perform an esophagogastroscopy in all @entity1 at adulthood until more long term follow-up data are available.

title: XXXX and @entity355 in adults born with @entity1152 .

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]

entities_list: @entity1152 :: ('MESH:D004933', 'Disease') :: ['esophageal atresia']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['reflux symptoms']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['small hiatal hernia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux', 'gastroesophageal reflux disease', 'reflux esophagitis']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity354 :: (MESH:D005764,Disease) :: ['Gastroesophageal reflux']


abstract: PURPOSE: The role of angiogenesis has been extensively evaluated in solid @entity5 and more recently in @entity1583 . Several surrogate markers of angiogenesis including @entity5 @entity7 , @entity7 receptors, and microvessel density have correlated with outcome in some @entity706 studies. This is a single institution retrospective study evaluating the role of angiogenesis markers in the clinical outcome of @entity1 with @entity1892 ( @entity1892 ). @entity1 AND METHODS: A total of 97 @entity1 with @entity1892 diagnosed and managed at Indiana University between 1993 and 2001 were included. @entity5 samples were stained for @entity7 , @entity9961 , @entity6758 , and @entity2279 and graded as negative or positive (1+, 2+, 3+). The relationship between the expression of these markers and the international prognostic variables as well as the progression free survival (PFS) and the overall survival (OS) was evaluated. RESULTS: @entity7 , @entity9961 , @entity6758 were expressed in 77, 98, and 18% of @entity5 , respectively. @entity7 negative @entity1 had an improved OS compared to @entity7 (1+) (P = 0.0502). @entity9961 correlated with both LDH (r = 0.28, P = 0.0502) and IPI score (r = 0.25, P = 0.013). @entity6758 negative @entity1 had a superior survival compared to those with @entity6758 (2+) (P = 0.0154). CONCLUSIONS: The presence of @entity5 associated angiogenesis may alter the outcome of @entity1 with @entity1892 and could be a prognostic factor. Further clinical studies are needed to correlate the degree of angiogenesis with response to anti-angiogenesis agents.

title: The importance of angiogenesis markers in the outcome of @entity1 with @entity1892 : a retrospective study of 97 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Archived tumor', 'tumors']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B cell lymphoma']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Perianal injection of @entity736 (Teflon or Polytef) paste was used in the treatment of 11 @entity1 with partial @entity1241 which followed internal sphincterotomy in 7 @entity1 and was idiopathic in 4. All @entity1 had been incontinent for more than 4 years, and had failed to respond to conservative measures. 5 ml of Polytef paste were injected, without anesthesia, in the @entity135 , above the pectinate line at each of the 3 and 9 o'clock positions. @entity1 were followed for 18 to 24 months. They were categorized into 3 scores: 1, cured; 2, improved, and 3, no change. Long-term cure (score 1) occurred in 45.4% after the 1st injection and in 63.6% after the 2nd injection. 36.4% showed partial improvement (score 2). No failures occurred. Improvement is believed to be due to the increase in rectal neck pressure produced by the cushion-effect of the polytef submucosal injection. The technique is simple, easy and without complications. It is performed on an outpatient basis.

title: XXXX injection for the treatment of partial @entity1241 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['rectal neck submucosa']

entities_list: @entity1241 :: ('MESH:D005242', 'Disease') :: ['fecal incontinence']

answer: @entity736 :: (CHEBI:53251,Chemical) :: ['Polytetrafluoroethylene']


abstract: OBJECTIVES: The use of computers to test cognitive function acutely after a concussion is becoming increasingly popular, especially after sport-related concussion. Although commonly performed in the community, it is not yet performed routinely in the @entity341 ( @entity341 ), where most injured @entity1 present. The challenges of performing computerized cognitive testing (CCT) in a busy @entity341 are considerable. The aim of this study was to evaluate the feasibility of CCT in the pediatric @entity341 after concussion. METHODS: @entity1 , aged 8 to 18 years with mild @entity131 , presenting to the @entity341 were eligible for this prospective study. Exclusion criteria included the use of drugs, @entity285 , and/or @entity130 , which could affect CCT performance. A 30- or 15-minute CCT battery was performed. Feasibility measures included environmental factors (space, noise, waiting time), testing factors (time, equipment reliability, personnel), and @entity1 factors (age, injury characteristics). RESULTS: Forty-nine @entity1 (28 @entity1 ; mean age, 12.6; SD,    2.5) participated in the study. All @entity1 completed CCT. Mean testing times for the 30- and 15-minute battery were 29.7 and 15.2 minutes, respectively. Noise-cancelling headphones were well tolerated. A shorter CCT was more acceptable to families and was associated with fewer @entity132 . There was sufficient time to perform testing after triage and before physician assessment in over 90% of @entity1 . CONCLUSIONS: Computerized cognitive testing is feasible in the @entity341 . We highlight the unique challenges that should be considered before its implementation, including environmental and testing considerations, as well as personnel training.

title: Incorporating a Computerized Cognitive Battery Into the Emergency Department Care of Pediatric Mild XXXX Injuries-Is It Feasible?

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'patient', 'boys']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity132 :: ('MESH:D010468', 'Disease') :: ['noise disturbances']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['physical injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain']


abstract: The orientation of mannosidase II, an integral Golgi membrane protein involved in @entity2734 -linked oligosaccharide processing, has been examined in @entity35 liver Golgi membranes. Previous studies on mannosidase II purified from Golgi membranes revealed an intact subunit of 124,000 daltons, as well as a catalytically active 110,000-dalton degradation product generated during purification (Moremen, K. W., and Touster, O. (1985) J. Biol. Chem. 260, 6654-6662). In Triton X-100 extracts of Golgi membranes, the intact enzyme was cleaved by a variety of proteases to generate degradation products similar to those observed previously. At appropriate concentrations, chymotrypsin, pronase, and proteinase K generated 110,000-dalton species, while trypsin and @entity794 V8 protease generated 115,000-dalton forms. Cleavage by chymotrypsin under mild conditions (10 micrograms/ml, 10 min, 20 degrees C) resulted in a complete conversion to a catalytically active 110,000-dalton form of the enzyme which was extremely resistant to further degradation. Attempts to demonstrate these protease digestions in nonpermeabilized Golgi membranes were unsuccessful, a result suggesting that the protease-sensitive regions are not accessible on the external surface of the membrane. In Golgi membranes permeabilized by treatment with 0.5% @entity3857 , mannosidase II could readily be cleaved to the 110,000-dalton form by digestion with chymotrypsin under conditions similar to those which result in a proteolytic inactivation of @entity23460 , a lumenal Golgi membrane marker. Although mannosidase II catalytic activity was not diminished by this chymotrypsin digestion, as much as 90% of the enzyme activity was converted to a nonsedimentable form. To examine the effect of the proteolytic cleavage on the partition behavior of the enzyme, control and chymotrypsin-treated Triton X-114 extracts of Golgi membranes were examined by phase separation at 35 degrees C. The undigested enzyme partitioned into the detergent phase consistent with its location as an integral Golgi membrane protein, while the 110,000-dalton chymotrypsin-digested enzyme partitioned almost exclusively into the aqueous phase in a manner characteristic of a soluble protein. These results suggest that mannosidase II catalytic activity resides in a proteolytically resistant, hydrophilic 110,000-dalton domain. Attachment of this catalytic domain to the lumenal face of Golgi membranes is achieved by a proteolytically sensitive linkage to a 14,000-dalton hydrophobic membrane anchoring domain.

title: Topology of mannosidase II in XXXX liver Golgi membranes and release of the catalytic domain by selective proteolysis.

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity2734 :: ('CHEBI:17196', 'Chemical') :: ['asparagine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: PURPOSE: Randomized trials have demonstrated that adjuvant chemotherapy improves survival for @entity1 with @entity5 and that chemotherapy combined with radiation therapy improves survival for @entity1 with @entity5 . This population-based study was designed to assess use of these treatments in clinical practice. @entity1 AND METHODS: From the California @entity5 Registry, we identified all @entity1 diagnosed during 1996 to 1997 with @entity5 (n = 1,422) and @entity5 (n = 534) in 22 northern California counties. To supplement registry data on adjuvant therapies and ascertain reasons they were not used, we surveyed physicians or reviewed office records for 1,449 @entity1 (74%). RESULTS: Chemotherapy rates varied widely by age from 88% (age < 55 years) to 11% (age >or= 85 years), and radiation therapy varied similarly. Adjusting for demographic, clinical, and hospital characteristics, chemotherapy was used less often among older and unmarried @entity1 , and radiation therapy was used less often among older @entity1 , black @entity1 , and those initially treated in low-volume hospitals. Adjusted rates of chemotherapy varied significantly (P <.01) among individual hospitals: 79% and 51%, respectively, at one SD above and below average (67%). Physicians' reasons for not providing adjuvant therapy included @entity1 refusal (30% for chemotherapy, 22% for radiation therapy), comorbid illness (22% and 14%, respectively), or lack of clinical indication (22% and 45%, respectively). CONCLUSION: Use of adjuvant therapy for @entity14 varies substantially by age, race, marital status, hospital volume, and individual hospital, indicating opportunities to improve care. With enhanced data on adjuvant therapies, population-based registries could become a valuable resource for monitoring the quality of @entity5 care.

title: Use of adjuvant chemotherapy and radiation therapy for XXXX in a population-based cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II or III rectal cancer', 'stage III colon cancer', 'cancer', 'Cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: To evaluate the clinico-epidemiological profile, pattern of infections, feeding practices, socio-demographic risk factors and outcome of hospitalized @entity1 with moderate acute @entity3147 (MAM) and @entity697 ( @entity697 ). METHODS: Cases ( @entity1 aged 1-60 mo with @entity697 or MAM) and controls ( @entity1 with weight for height z score more than -1 SD) were recruited from November 2011 through July 2013. Overall, 126 cases and 126 controls were included. RESULTS: Only 33  % of malnourished @entity1 (cases) were exclusively breast fed. Among controls, 71  % were exclusively breast fed for the first 6 mo after birth. Most cases had associated infections (p 0.004) and @entity417 (p   <   0.001). ROC curve revealed 120  mm mid upper arm circumference (MUAC) as the best cut off for predicting @entity697 . Mothers' education, pre-lacteal feeds and co-morbidities were independent predictors of @entity3147 (R(2)   =   22.1  %) by logistic regression. CONCLUSIONS: Though 11.5  cm MUAC has been mentioned by WHO as the cut off for identifying @entity697 , a higher cut off (12  cm) may be required to use it as a screening tool. Mothers' education, pre-lacteal feeds and co-morbidities were found to be independent determinants for @entity3147 in the present @entity1 population, indicating the need towards a targeted approach for modifying these factors.

title: Epidemiological and Clinical Profile of Hospitalized @entity1 with Moderate and Severe Acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['SAM', 'severe acute malnutrition']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

answer: @entity3147 :: (MESH:D044342,Disease) :: ['Malnutrition in South India']


abstract: @entity8710 exposure has been associated with @entity1893 ( @entity1893 ) in epidemiological investigations. The @entity1893 -related t(14;18) translocations can be detected at a low copy number in lymphocytes from healthy subjects. Exposure to @entity1893 , such as @entity8710 or pesticides, may cause expansion of t(14;18)-positive clones. We investigated prevalence and frequency of circulating t(14;18)-positive lymphocytes in 144 healthy subjects from a population exposed to @entity8710 [plasma @entity1300 ( @entity1300 ) range: <1.7-475.0 parts per trillion (p.p.t.)] after the Seveso, Italy, accident of 1976. t(14;18) translocations were measured in DNA from peripheral blood lymphocytes by high-sensitivity real-time quantitative polymerase chain reaction. We found that the frequency, but not the prevalence, of t(14;18) translocation-positive cells increased with increasing plasma @entity1300 . Among t(14;18)-positive subjects (n = 50;34.7%), the mean number of t(14;18) translocations/10(6) lymphocytes was 4.2 [95% confidence interval (CI), 2.9-6.2] in subjects with plasma @entity1300 < 10.0 p.p.t., 8.1 (95% CI, 4.9-13.3) in subjects with plasma @entity1300 between 10.0 and 50.0 and 12.5 (95% CI, 7.4-21.1) in subjects with plasma @entity1300 between 50.0 and 475.0 p.p.t. (P-trend = 0.003). As expected, t(14;18) frequency was associated with cigarette smoking and was highest in subjects who smoked for > or =16 years (mean = 12.6; 95% CI, 7.4-21.3; P = 0.01). Higher t(14;18) prevalence was found among individuals with fair hair color (P = 0.01) and light eye color (P = 0.04). No significant association between t(14;18)-and age was found. Our results show that @entity8710 exposure is associated with increased number of circulating t(14;18) positive cells. Whether this change in t(14;18) frequency is an indicator of @entity706 risk remains speculative and needs further investigation for its potential impact on public health.

title: t(14;18) translocations in lymphocytes of healthy XXXX -exposed individuals from Seveso, Italy.

entities_list: @entity8710 :: ('CHEBI:28119', 'Chemical') :: ['dioxin', 'Dioxin']

entities_list: @entity1300 :: ('MESH:D013749', 'Chemical') :: ['TCDD', '2,3,7,8-tetrachlorodibenzo-p-dioxin']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL', 'NHL-associated carcinogens']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['elevated lymphoma']

answer: @entity8710 :: (CHEBI:28119,Chemical) :: ['dioxin']


abstract: Background:Deep sedation or general anesthesia is generally used during @entity955 ( @entity955 ) ablation. The aim of this study was to report the safety and feasibility of minimal sedation during @entity955 ablation.Methods   and   Results:One thousand and fifty-two @entity955 ablation procedures in 819 @entity1 (62  11 years, 621 @entity1 , 506 paroxysmal) were included. Boluses of intravenous @entity5774 and @entity12586 were administered, with a maximal dose of 100 mg of @entity5774 and 60 mg of @entity12586 in response to @entity158 . If the @entity158 was intolerable or @entity1 requested deeper sedation, moderate sedation using @entity6948 or @entity1875 was introduced. Among 819 consecutive first procedures, the procedure was completed under minimal sedation in 795 (97.1%) @entity1 without inotropic drugs or respiratory support, whereas in 20 (2.4%) @entity1 , anesthesia was switched to moderate sedation due to @entity158 . @entity1 requiring a switch to moderate sedation were significantly younger than those without (53.6  2.3 vs. 62.6  10.4, P<0.01). No procedures were abandoned due to adverse effects of sedation. Significant intra-procedural blood pressure decreases requiring inotropic drugs were not observed in any @entity1 . Among 233 @entity1 who underwent repeat procedures, 6 (2.6%) requested moderate sedation before the procedure. The mean procedure time was 151  54 min. @entity2293 , unrelated to sedation, was observed in 7 (0.66%) procedures.Conclusions:Minimal sedation might be acceptable anesthesia in the vast majority of @entity955 ablation procedures performed in electrophysiological laboratories.

title: Simple Minimal Sedation for Catheter Ablation of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men']

entities_list: @entity12586 :: ('MESH:D010423', 'Chemical') :: ['pentazocine']

entities_list: @entity2293 :: ('MESH:D002305', 'Disease') :: ['Cardiac tamponade']

entities_list: @entity5774 :: ('MESH:D006919', 'Chemical') :: ['hydroxyzine pamoate', 'hydroxyzine']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine']

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: The primary antibody response to @entity2945 (PC) is dominated by T15 antibodies. There are three families of anti-PC antibodies which can be made in @entity19 : T15, 511, and 603. All use the same H chain V, D, and J segments, but each anti-PC family has a different L chain, as well as a family-specific Vh-D junctional sequence. Here we test the hypothesis that T15 antibodies are dominant because the prototypic @entity57365 -D junction is generated in pre-B cells more often than the alternative non- @entity57365 -D junctional sequences. Rearranged IgH genes from DNA derived from fetal or newborn liver pre-B cells and from adult bone marrow pre-B cells of BALB/c @entity19 were amplified by polymerase chain reaction, cloned, and sequenced. DNA from adult splenic B cells was also amplified, for comparison. All V1-DFL16.1 and DFL16.1-Jh1 junctional sequences were analyzed. Fifty-three percent (9/17) of all neonatal pre-B cell V-D junctions with V1 and DFL16.1 had the prototypic T15 junctional sequence, which has no N regions. In contrast, no prototypic @entity57365 -D junctions were observed in adult pre-B cells, and each junctional sequence was unique. Adult splenic B cells contained an intermediate number of T15-type V-D junctional sequences (7/21). The prototypic D-J junctional sequence used in many anti-PC antibodies was also observed in a high percentage of sequences. The high frequency of T15 junctions in the neonatal pre-B cells can be explained by two observations: 1) N regions are absent in neonatal but not adult junctions and 2) in the absence of N regions, joining of V, D, and J segments may be targeted to short regions of sequence homology near the ends of the genes. This mechanism would preferentially give rise to the @entity57365 -D and D-J junctions. Preservation of the @entity57365 -D junction in adult splenic B cells is most likely due to antigenic stimulation of long lived precursors, because a high frequency of T15-type D-J junctions are coexpressed with @entity57365 -D junctions in splenic sequences. These results predict that T15 anti-PC precursors would be made at a very high frequency in the neonate, and at a much lower frequency in the adult. This may explain why the neonatal period is critical in establishing T15 dominance.

title: Predominance of the prototypic T15 anti- XXXX junctional sequence in neonatal pre-B cells.

entities_list: @entity2945 :: ('MESH:D010767', 'Chemical') :: ['phosphorylcholine']

entities_list: @entity57365 :: ('p|SUB|T|15|V', 'ProteinMutation') :: ['T15 V']

answer: @entity2945 :: (MESH:D010767,Chemical) :: ['phosphorylcholine']


abstract: BACKGROUND: Some @entity1 with advanced and progressive diseases express a desire to hasten @entity204 . AIM: This study evaluated the motivations of @entity1 expressing such a desire in a country with prohibitive legislation on euthanasia and physician-assisted suicide. DESIGN: A modified form of Grounded Theory was used. SETTING/ @entity1 : @entity1 from the departments of palliative medicine in three hospitals in Germany were recruited when they had made a statement or request to hasten @entity204 . @entity1 were interviewed face to face. Recruitment was stopped with 12 @entity1 because of data saturation. RESULTS: Thematic analysis revealed three main motivational themes: self-determination, agony, and time. Expectations toward health professionals, @entity204 , and secureness related to the end of life were additional main themes emerging from the analysis. CONCLUSIONS: The desire to hasten @entity204 may be used as an extreme coping strategy to maintain control against anticipated agony. @entity1 expected health professionals to listen to and respect their experiences. Emerging hypotheses included the following: (a) @entity1 try to balance life time and anticipated agony, and the perception of time is distressing in this balancing act; (b) anticipated images of agony and suffering in the dying process occur frequently and are experienced by @entity1 as intrusive; (c) @entity1 expressing a desire to hasten @entity204 are in need of more information about the dying process; and (d) @entity1 wanted their caregivers to listen to and respect their wish to hasten @entity204 , and they did not expect the caregivers to understand this as an order to actually hasten their @entity204 .

title: The desire to hasten XXXX : Using Grounded Theory for a better understanding "When perception of time tends to be a slippery slope".

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'Participants', 'PARTICIPANTS']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['attitudes toward death', 'death']

answer: @entity204 :: (MESH:D003643,Disease) :: ['death']


abstract: @entity130 is often complicated by @entity4858 . Such injuries may be difficult to detect and may therefore be missed. Detailed ophthalmic examinations were carried out prospectively on 363 @entity1 who had sustained midfacial @entity174 . Fifty four parameters comprising maxillofacial, radiological and ophthalmic data were recorded and coded for each @entity1 . All encoded data were divided into predictors (the data potentially available to the maxillofacial surgeon) and outcome (the data potentially available to the ophthalmologist). Statistical methods of regression, and the analysis of contingency tables, led to the identification of the principal predictors indicative of underlying @entity130 and thence to a scoring system which predicts the severity of such injuries. Impaired visual acuity is the principal predictor and when employed alone gives a sensitivity value of 80%. Pure blow-out @entity174 or @entity9256 , @entity892 and @entity2730 emerged as additional factors which yielded an efficient scoring system with a sensitivity of 89% and specificity of 90% for the population upon which it was based. A score sheet is provided in the paper. These predictors can be remembered from the acronym Blow-out @entity174 , Acuity, @entity892 , @entity2730 , Comminuted @entity130 . As many such injuries result from a BAD ACT, it is easily remembered. This scoring system requires to be tested upon a new population of individuals in order to determine its efficacy.

title: Midfacial XXXX and the eye: the development of a system for detecting @entity1 at risk of @entity4858 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity2730 :: ('MESH:D000647', 'Disease') :: ['amnesia', 'Amnesia']

entities_list: @entity4858 :: ('MESH:D005131', 'Disease') :: ['injury to the eye']

entities_list: @entity9256 :: ('MESH:D018460', 'Disease') :: ['comminuted facial fracture']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['double vision', 'Diplopia']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Maxillofacial trauma', 'Trauma', 'ophthalmic injury']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: @entity11530 ( @entity11530 ) is an @entity74 , in which @entity1 chronically pull hair from the scalp and/or other sites. Very early onset of @entity42639 in @entity1 under the age of 6 may be more benign and self-limiting than the more common syndrome of late childhood onset @entity42639 . While far more @entity1 and adolescent @entity1 appear for treatment, survey studies suggest chronic @entity42639 also occurs in males. Diagnosis may be complicated by @entity1 and family denial or ignorance of the @entity42639 ; accurate scalp examination and biopsy can be critical. Classic scalp biopsies for @entity11530 , @entity2118 , peribulbar @entity548 and hair canal pigment casts, and lack lymphocytic infiltrates seen in @entity1665 areata. Treatment is difficult: the tricyclic antidepressant @entity8991 is the most promising agent, although many @entity1 find it difficult to tolerate at adequate dosages, and treatment response may not be maintained over the long term. More benign medications have not demonstrated efficacy in controlled studies. Augmentation with topical preparations or psychotropic medications may be helpful for @entity1 experiencing limited efficacy or relapse. Specialized psychotherapy, known as habit reversal training, is highly recommended; however, the treatment is intensive and highly specialized. Skilled therapists are difficult to locate.

title: XXXX . Presentation, etiology, diagnosis and therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'patient', 'girls']

entities_list: @entity8991 :: ('MESH:D002997', 'Chemical') :: ['clomipramine']

entities_list: @entity42639 :: ('MESH:D006201', 'Disease') :: ['hair pulling']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigment clumps']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['impulse disorder']

entities_list: @entity11530 :: ('MESH:D014256', 'Disease') :: ['TTM feature trichomalacia', 'TTM', 'Trichotillomania']

answer: @entity11530 :: (MESH:D014256,Disease) :: ['Trichotillomania']


abstract: AMS: To describe the characteristics and surgical outcomes of full thickness macular hole surgery after laser assisted in situ keratomileusis (LASIK) for the correction of @entity1714 . METHODS: 13 @entity1 (14 eyes) who developed a macular hole after bilateral LASIK for the correction of @entity1714 participated in the study. RESULTS: Macular hole formed 1-83 months after LASIK (mean 13 months). 11 out of 13 (84.6%) @entity1 were female. Mean age was 45.5 years old (25-65). All eyes were myopic (range -0.50 to -19.75 dioptres (D); mean -8.4 D). @entity20699 ( @entity20699 ) was not present before and was documented after LASIK on 42.8% of eyes. Most macular hole were unilateral, stage 4 macular hole, had no yellow deposits on the retinal pigment epithelium, had no associated epiretinal membrane, were centric, and had subretinal fluid. The mean diameter of the hole was 385.3 microm (range 200--750 microm). A vitrectomy closed the macular hole on all eyes with an improvement on final best corrected visual acuity (VA) on 13 out of 14 (92.8%) @entity1 . CONCLUSIONS: This study shows that vitreoretinal surgery can be successful in restoring vision for most @entity735 with a macular hole after LASIK.

title: Vitreoretinal surgery for macular hole after laser assisted in situ keratomileusis for the correction of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['myopic eyes']

entities_list: @entity20699 :: ('MESH:D020255', 'Disease') :: ['Posterior vitreous detachment', 'PVD']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['myopia']


abstract: OBJECTIVE: To compare real-life clinical outcomes with the levonorgestrel-releasing intrauterine system (LNG-IUS) and @entity7617 ( @entity7617 ), including combined oral contraceptives and oral progestins in the treatment of @entity548 (HMB) in South Korea. METHODS: This prospective, observational cohort study recruited a total of 647 @entity1 aged 18 to 45 years, diagnosed with HMB from 8 countries in Asia, including 209 @entity1 from South Korea (LNG-IUS, 169; @entity7617 , 40), who were followed up to one year. The primary outcome was cumulative continuation rate (still treated with LNG-IUS and @entity7617 ) at 12 months. Secondary outcomes included @entity548 pattern, assessment of the treatment efficacy by treating physician and safety profile. RESULTS: The continuation rate at 12 months was significantly higher with the LNG-IUS than @entity7617 (85.1% vs. 48.5%, respectively; P<0.0001). The 51.5% of @entity7617 @entity1 discontinued treatment and 18.8% of LNG-IUS @entity1 discontinued treatment. The most common reasons for discontinuation for @entity7617 were switching to another treatment and personal reasons. When compared to @entity7617 , the LNG-IUS offered better reduction in subjectively assessed menstrual @entity190 and the number of @entity548 days, tolerability and with better efficacy in HMB, as assessed by physician's final evaluation. CONCLUSION: This study provides novel information on the real-life treatment patterns of HMB in South Korea. The efficacy of @entity7617 was inferior compared to the LNG-IUS in the clinical outcomes measured in this study. Due to the better compliance with LNG-IUS, the cumulative continuation rate is higher than @entity7617 . We conclude that the LNG-IUS should be used as the first-line treatment for HMB in Korean @entity1 , in line with international guidelines.

title: Therapy of heavy XXXX in Korea: Subanalysis and results from a multinational clinical trial in the Asian region investigating the levonorgestrel-releasing intrauterine system versus conventional therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity7617 :: ('MESH:C563514', 'Disease') :: ['conventional medical therapies', 'CMTs']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'idiopathic heavy menstrual bleeding']

answer: @entity548 :: (MESH:D006470,Disease) :: ['menstrual bleeding']


abstract: OBJECTIVE: Symptomatic @entity1797 develops from inflammatory reactions in the annulus fibrosus ( @entity6343 ). Although inflammatory mediators during annular @entity32 have been studied, the roles of matrix metalloproteinases (MMPs) and their inhibitors have not been fully elucidated. In this study, we evaluated the production of MMPs and tissue inhibitors of metalloproteinase (TIMPs) during annular @entity32 using an in vitro co-culture system. We also examined the effect of notochordal cells on annular @entity32 . METHODS: @entity1 @entity6343 ( @entity6343 ) pellet was co-cultured for 48 hours with @entity4514 -stimulated macrophage-like THP-1 cells. @entity6343 pellet and conditioned media (CM) from co-cultured cells were assayed for MMPs, TIMPs, and @entity442 levels using real-time reverse-transcriptase polymerase chain reaction and enzyem-linked immunosorbent assay. To evaluate whether notochordal cells affected MMPs or TIMPs production on annular @entity32 , @entity6343 co-cultured with notochordal cells from adult New Zealand White @entity95 , were assayed. RESULTS: @entity3334 ; and @entity2843 levels were significantly increased in CM of @entity6343 co-cultured with macrophage-like cells compared with @entity6343 alone, whereas @entity1552 and @entity442 levels were significantly decreased (p<0.05). After macrophage exposure, @entity6343 produced significantly more @entity12653 and less @entity16617 . @entity1356 stimulation enhanced @entity12653 levels, and significantly diminished @entity1552 levels. Co-culturing with @entity95 notochordal cells did not significantly influence MMPs and TIMPs production or @entity60920 gene expression. CONCLUSION: Our results indicate that macrophage-like cells evoke annular degeneration through the regulation of major degradative enzymes and their inhibitors, produced by @entity6343 , suggesting that the selective regulation of these enzymes provides future targets for symptomatic @entity1797 therapy.

title: Matrix Degradative Enzymes and Their Inhibitors during Annular Inflammation: Initial Step of Symptomatic XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1797 :: ('MESH:D055959', 'Disease') :: ['disc degeneration']

entities_list: @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor (IGF)-1', 'IGF-1']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity4514 :: ('MESH:D013755', 'Chemical') :: ['phorbol myristate acetate']

answer: @entity1797 :: (MESH:D055959,Disease) :: ['Intervertebral Disc Degeneration']


abstract: PURPOSE: The use of @entity3194 (ICG) during intraoperative internal limiting membrane (ILM) peeling is common for various @entity1020 . The authors observed residual ICG after vitrectomy for @entity1714 -related @entity1020 and found a unique pattern specific to its pathologic features. DESIGN: Observational case series. METHODS: Twelve eyes of 12 @entity1 with @entity1714 who had undergone vitrectomy with ICG-assisted ILM peeling were included ( @entity937 [ @entity937 ], six eyes; @entity937 and @entity1713 , three eyes; and @entity14847 , three eyes). Patterns of residual ICG were observed in the posterior retina using the Heidelberg Retina Angiograph 2 (Heidelberg Engineering, Heidelberg, Germany) after surgery and were compared. The minimum follow-up was six months. Two control eyes of two @entity1 without intravitreal ICG also were included in this study. RESULTS: The residual ICG fluorescence was observed in all eyes except for the control eyes. The pattern of residual ICG fluorescence depended on the degree of @entity5066 . In eyes with no or minimum @entity5066 , the pattern was similar to that of an idiopathic @entity937 . The ICG pattern was unique in those with moderate or severe @entity194 . A strong ICG signal was observed at the area of diffuse @entity194 and at the edge of the patchy @entity194 and @entity1716 . No ICG fluorescence was observed inside the patchy @entity194 . CONCLUSIONS: Residual ICG fluorescence was observed in @entity1714 . ICG accumulation seems to depend on the status of the retinal pigment epithelial (RPE) underlying the posterior retina. RPE cells may play an important role in the kinetics of the residual ICG.

title: Residual @entity3194 fluorescence pattern after vitrectomy with internal limiting membrane peeling in XXXX .

entities_list: @entity5066 :: ('MESH:C566236', 'Disease') :: ['chorioretinal atrophy', 'myopic chorioretinal atrophy']

entities_list: @entity937 :: ('MESH:D012167', 'Disease') :: ['macular hole', 'MH']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['retinal detachment']

entities_list: @entity1716 :: ('MESH:C536352', 'Disease') :: ['staphyloma']

entities_list: @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green']

entities_list: @entity14847 :: ('MESH:C567024', 'Disease') :: ['myopic foveoschisis']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular diseases']

entities_list: @entity1714 :: ('MESH:D009216', 'Disease') :: ['high myopia']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['high myopia']