abstract: Obesity-related @entity249 is one of the most common problems of reproductive-age @entity28 @entity1 who desire childbearing. The various types of bariatric surgeries have proved effective in controlling excessive @entity1017 , improving fertility, and preventing certain maternal and fetal complications in these @entity1 . This article summarizes the current evidence regarding the impact of bariatric surgery on @entity28 -related @entity249 and @entity52 ( @entity52 ) outcomes. We have also attempted to draw conclusions about maternal and fetal risks and the benefits of bariatric surgery. Laparoscopic adjustable gastric banding and Roux-en-Y procedures are the two most commonly performed bariatric surgeries. Bariatric surgery was believed to improve @entity1866 and increase ovulation rate in @entity28 @entity1 , which lead to increased pregnancy rates. Although there are data in the literature suggesting the improvement of both the ovulatory function and the spontaneous pregnancy rates in @entity28 @entity1 who lost weight after bariatric surgery, most of these are case-control studies with a small number of @entity1 . The data are insufficient to determine an ideal time interval for pregnancy after bariatric surgery; however, the general consensus is that pregnancy should be delayed 12 to 18 months after bariatric surgery to avoid @entity3147 . Few data exist regarding @entity52 success rates in @entity1 who have undergone bariatric surgery. One pairwise study discussed five @entity1 who underwent bariatric surgery followed by @entity52 that resulted in three term pregnancies in three @entity1 after the first @entity52 cycle. Many studies reported reductions in @entity28 -related pregnancy complications such as gestational @entity6 and @entity101 after bariatric surgery. Although data are inconsistent, some studies reported increased rate of @entity3152 and small for gestational age @entity1 after bariatric surgery. Pregnancies after bariatric surgery may be considered high risk due to the concerns for @entity15248 and @entity344 related to the surgery. Therefore the follow-up of these pregnancies might require a team approach including a maternal fetal medicine specialist, bariatric surgeon, and nutritionist.

title: The impact of bariatric surgery on @entity28 -related XXXX and @entity52 outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'infants']

entities_list: @entity15248 :: ('MESH:D001361', 'Disease') :: ['vitamin deficiencies']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive disorders']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['anovulatory obese', 'obese', 'obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms']

entities_list: @entity1866 :: ('MESH:D008599', 'Disease') :: ['menstrual irregularity']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['nutritional deficiencies']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertility']


abstract: BACKGROUND: Increasing aortic diameter is thought to be an important risk factor for @entity8625 ( @entity8625 ). However, some @entity1 develop @entity8625 in the absence of @entity384 . In this report, we sought to characterize @entity8625 @entity1 who presented with a descending thoracic aortic diameter <3.5 cm. METHODS: We categorized 613 @entity8625 @entity1 enrolled in the International Registry of Acute Aortic Dissection from 1996 to 2009 according to the aortic diameter <3.5 cm (group 1) and >= 3.5 cm (group 2). Demographics, clinical presentation, management, and outcomes of the two groups were compared. RESULTS: Overall, 21.2% (n = 130) had an aortic diameter <3.5 cm. @entity1 in group 1 were younger (60.5 vs 64.0 years; P = .015) and more frequently female (50.8% vs 28.6%; P < .001). They presented more often with @entity6 (10.9% vs 5.9%; P = .050), history of catheterization (17.0% vs 6.7%; P = .001), and coronary artery bypass grafting (9.7% vs 3.4%; P = .004). @entity1614 was equally distributed in the two groups. The overall in-hospital mortality did not differ between groups 1 and 2 (7.6% vs 10.1%; P = .39). CONCLUSIONS: About one-fifth of @entity1 with @entity8625 do not present with any @entity384 . These @entity1 are more frequently females and younger, when compared with @entity1 with @entity384 . This report is an initial investigation to clinically characterize this cohort, and further research is needed to identify risk factors for @entity1580 in the absence of @entity384 .

title: Acute XXXX in the absence of @entity384 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['aortic dilatation']

entities_list: @entity1614 :: ('MESH:D008382', 'Disease') :: ['Marfan syndrome']

entities_list: @entity8625 :: ('MESH:D015456', 'Disease') :: ['acute type B aortic dissection', 'ABAD']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

answer: @entity1580 :: (MESH:C562834,Disease) :: ['type B aortic dissection']


abstract: From 1971 to 1985, 21 @entity1 received megavoltage external beam radiation therapy at the University of Pittsburgh for control of @entity976 . Minimum @entity5 doses prescribed to the 95% isodose volume ranged between 51.3 to 70.0 Gy. Median total dose was 60.00 Gy and median dose per fraction was 1.83 Gy. Three @entity204 occurred from intercurrent disease and no @entity204 from @entity5 progression. Actuarial overall survival was 89% and 82% at 5 and 10 years. Actuarial local control was 95% at 5 and 10 years. Radiation related complications included one @entity1 with @entity1781 , one with @entity39 , and one that developed @entity1781 followed by @entity39 . The high dose group of @entity1 who received a NSD or Neuret equivalent of greater than 60 Gy at 1.8 Gy per fraction had a significantly greater risk of radiation complications (p = .024). The actuarial risk at 5 years for @entity1781 was 30% and @entity39 was 12.5% in the high dose group. Tumor control in the high dose group was not shown to be significantly better. Any possible benefit in @entity5 control in treating @entity1 with @entity976 with doses above 60 Gy at 1.8 Gy per fraction appears to be offset by the increased risk of @entity1161 .

title: Megavoltage external beam irradiation of @entity976 : analysis of XXXX control and morbidity.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['brain necrosis']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation injury']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy']

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['craniopharyngioma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: The @entity460 antagonist @entity4271 suppresses pathologic accumulation of @entity460 intracellularly without affecting the fast @entity1372 or the slow @entity460 channel. To establish its value in differentiating between mechanisms of @entity943 in the @entity235 heart, the effect of @entity4271 was investigated on @entity1165 ( @entity1165 ) induced by @entity7832 intoxication or occurring 16-24 hours after occlusion of the left anterior descending coronary artery. Four groups of @entity235 were studied. Group 1 consisted of 13 animals with @entity1165 induced by @entity7832 intoxication (triggered-activity group). Group 2 included nine @entity235 in whom @entity1165 developed 16-24 hours after occlusion of the left anterior descending coronary artery (abnormal automaticity group). Group 3 included six @entity235 with normally conducted sinus beats, whereas group 4 consisted of six animals having a @entity67 . With the exception of group 3, all @entity235 had surgically induced complete @entity713 . All animals were studied while conscious and without premedication. In groups 1 and 2, 2-3 mg/kg @entity4271 was given intravenously after @entity1165 had persisted for at least 20 minutes. In groups 3 and 4, 2 mg/kg @entity4271 was given after the rhythm was registered for 20 minutes. The cycle lengths of the different rhythms were compared before and after @entity4271 . In group 1, @entity4271 increased the cycle length of the @entity1165 from 300 +/- 30 to 410 +/- 50 msec (p less than or equal to 0.001). Termination of @entity1165 was seen in 11 out of 13 animals. In group 2, @entity4271 resulted in a nonsignificant shortening of the RR interval from 450 +/- 60 to 440 +/- 60 msec. Persistent termination was observed in only one of nine @entity235 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX allows differentiation between mechanisms of @entity943 in the intact heart.

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity4271 :: ('MESH:D005444', 'Chemical') :: ['flunarizine']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular escape rhythm']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

answer: @entity4271 :: (MESH:D005444,Chemical) :: ['Flunarizine']


abstract: AIM: This study evaluated the immunogenicity and safety of tetravalent measles-mumps- @entity2462 (MMRV) vaccine produced with measles and @entity2462 monovalent bulks derived from a newly established working seed virus stock (MMRV(new @entity3297 )) compared with the combined MMRV vaccine derived from the current seed virus stock, in Taiwanese and Singaporean @entity1 (NCT00892775). METHODS: Healthy @entity1 aged 11-22 mo were randomized to receive two doses of either the MMRV(new @entity3297 ) vaccine or the MMRV vaccine. Antibody titers against measles, mumps and @entity2462 were measured using ELISA and against varicella using an immunofluorescence assay. The primary objective was to demonstrate non-inferiority of MMRV(new @entity3297 ) to MMRV in terms of post-dose-1 seroconversion rates, defined as a group difference with a lower limit of the 95% confidence interval greater than -10% for each antigen. Parents/guardians recorded symptoms in diary cards for 43 d after each vaccine dose. RESULTS: Non-inferiority of MMRV(new @entity3297 ) to MMRV was achieved for all vaccine antigens. The lower limits of the 95% confidence intervals for group differences (MMRV(new @entity3297 ) group vs. MMRV) for measles (99.4% vs 100%), mumps (89.7% vs 90.4%), @entity2462 (99.7% vs 100%) and varicella (97.6% vs 92.9%) seroconversion rates were greater than -10%. Mild symptoms including a peak in fever between days 5 and 12, post-dose-1, was observed in both groups. CONCLUSION: The immune responses elicited by the MMRV(new @entity3297 ) vaccine were non-inferior to that elicited by the MMRV vaccine for all antigens. Both vaccines exhibited an acceptable safety profile in Taiwanese and Singaporean @entity1 .

title: Immunogenicity and safety of combined measles-mumps- @entity2462 vaccine using new measles and XXXX working seeds in healthy @entity1 in Taiwan and Singapore: a phase II, randomized, double-blind trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2462 :: ('MESH:D012409', 'Disease') :: ['rubella', 'rubella-varicella']

answer: @entity2462 :: (MESH:D012409,Disease) :: ['rubella']


abstract: BACKGROUND: @entity36182 is currently recognized as a significant pathogen of the pediatric population. Nevertheless, the possibility for adults to serve as a reservoir of healthy carriers has not been studied. METHOD: We conducted a monocentric transversal study on 228 healthy adults to define the carriage rate. @entity1 were recruited among the staff of a @entity1 's hospital, a population exposed to aerosolized droplets from @entity1 . A secondary analysis using a case-control method was conducted to assess risk factors for carriage. RESULTS: We demonstrated an oropharyngeal carriage rate of 2.2% in this population. However, there was a striking similarity in the carriage rate among @entity1 younger than 4 years of age and adults living with @entity1 of that age group (8.8%). Use of day-care facilities for their own @entity1 was also demonstrated as a risk factor for adult carriage. CONCLUSIONS: We were able to demonstrate the existence of adult carriage of @entity36182 but our results point to transmission from @entity1 to adults. Our results do not allow us to conclude that professional exposure in a hospital setting is a risk factor for oropharyngeal carriage.

title: Identifying Reservoirs of Infections Caused by @entity36182 : A Case-Control Study of Oropharyngeal Carriage of XXXX Among Healthy Adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'children']

entities_list: @entity36182 :: ('504', 'Species') :: ['Kingella kingae', 'K. kingae']

answer: @entity36182 :: (504,Species) :: ['K. kingae']


abstract: BACKGROUND: Expanded GGGGCC hexanucleotide repeats in the promoter of the @entity3301 gene have recently been identified in @entity4943 ( @entity4943 ), @entity746 ( @entity746 ) and @entity746 - @entity4943 and appear as the most common genetic cause of familial ( @entity7104 ) and sporadic (SALS) forms of @entity746 . METHODS: We searched for the @entity3301 repeat expansion in 950 French @entity746 @entity1 (225 @entity7104 and 725 SALS) and 580 control subjects and performed genotype-phenotype correlations. RESULTS: The repeat expansion was present in 46% of @entity7104 , 8% of SALS and 0% of controls. Phenotype comparisons were made between @entity7104 @entity1 with expanded @entity3301 repeats and @entity1 carrying another @entity746 -related gene ( @entity1367 , @entity529 , @entity19957 ) or a yet unidentified @entity74 . SALS @entity1 with and without @entity3301 repeat expansions were also compared. The @entity3301 group presented more frequent bulbar onset both in @entity7104 (p<0.0001 vs @entity1367 , p=0.002 vs @entity529 , p=0.011 vs @entity19957 , p=0.0153 vs other @entity7104 ) and SALS (p=0.047). @entity7104 @entity1 with @entity3301 expansions had more frequent association with @entity4943 than the other @entity7104 @entity1 (p<0.0001 vs @entity1367 , p=0.04 vs @entity529 , p=0.004 vs @entity19957 , p=0.03 vs other @entity7104 ). @entity3301 -linked @entity7104 @entity1 presented an older age of onset than @entity1367 (p=0.0139) or @entity19957 mutation (p<0.0001) carriers. Disease duration was shorter for @entity3301 expansion carriers than for @entity1367 (p<0.0001) and @entity529 (p=0.0242) carriers, other @entity7104 (p<0.0001) and @entity3301 -negative SALS (p=0.0006). CONCLUSIONS: Our results confirm the major role of expanded repeats in @entity3301 as causative for @entity746 and provide evidence for specific phenotypic aspects compared to @entity1 with other @entity746 -related genes.

title: Phenotype difference between XXXX @entity1 with expanded repeats in @entity3301 and @entity1 with mutations in other @entity746 -related genes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic defect']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'Amyotrophic Lateral Sclerosis']

entities_list: @entity4943 :: ('MESH:D057180', 'Disease') :: ['FTD', 'frontotemporal dementia']

answer: @entity746 :: (MESH:D000690,Disease) :: ['ALS']


abstract: A 40-year-old @entity1 was referred to our Department of Surgery because of an abdominal wall mass. Sixteen years earlier, she had undergone surgical resection of an inguinal @entity5 that had been diagnosed as a @entity5426 . Fourteen months after the initial resection, the @entity5 recurred locally, and complete resection was performed. Twenty-nine months later, computed tomography showed multiple @entity3 in the lung. All these @entity5 were resected during thoracoscopic surgery. Thirteen years after the @entity1 's 3rd operation, a firm mass was detected in the left lower quadrant of the abdominal wall. Magnetic resonance image showed a well-defined mass with heterogeneous contrast enhancement within the rectus abdominis muscle. Positron emission tomography-computed tomography demonstrated no recurrent @entity5 other than this mass. Complete resection was performed. Microscopic examination showed that this @entity5 was composed of hypercellular spindle cells and staghorn-shaped blood vessels. The average number of mitotic figures was 28 per 10 high-power fields. Immunohistochemical examination of the @entity5 showed focal positivity for @entity2280 . Therefore, the @entity5 was diagnosed as a metastatic @entity2698 with malignant potential. Careful long-term follow-up is required because metastases can develop after an extended disease-free interval. Aggressive surgical treatment is recommended for distant metastases.

title: A case of metastatic @entity2698 occurring 16 years after initial presentation: with special reference to the clinical behavior and treatment of metastatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity2698 :: ('MESH:D006393', 'Disease') :: ['hemangiopericytoma']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['hemangiosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumors']

answer: @entity2698 :: (MESH:D006393,Disease) :: ['hemangiopericytoma']


abstract: A fully pump-assisted continuous veno-venous hemodiafiltration system (CVVHDF) was studied in 10 @entity810 @entity1 . A counter current pump system ensured slow dialysis at a mean flow rate of 24.6 +/- 0.6 ml/min (single pass) and guaranteed recovery of 97% of dialysate. Ultrafiltration rates were controlled by a separate occlusive pump, connected to the dialysate compartment. Blood was circulated by mean of a third pump at flow rates ranging form 100 to 150 ml/min. Mean duration of CVVHDF was 197 +/- 32 h (range 96-336). Mean serum @entity1011 and @entity1133 before initiation of CVVHDF were 525 +/- 52 mumol/l and 36 +/- 14 mmol/l and stabilized after 4-7 days of CVVHDF at 280 +/- 27 mumol/l and 14 +/- 3 mmol/l. Hemodynamic parameters remained stable. @entity413 and @entity1391 removal by CVVHDF was 296 +/- 42 mmol/day and 33 +/- 6 mmol/day respectively. Fractional losses of aminoacids given by parenteral nutriton averaged 8 +/- 1%. @entity8606 filters induced no significant changes in leucocyte and thrombocyte counts and only a slight decrease in @entity4095 (-0.78 +/- 0.30 K Pa at 60 min). We conclude that CVVHDF is a safe, efficient and reliable treatment modality, allowing a good control of the fluid balance.

title: [Continuous veno-venous hemofiltration in XXXX ].

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['Glucose']

answer: @entity810 :: (MESH:D058186,Disease) :: ['acute renal insufficiency']


abstract: PURPOSE: We have previously shown that fibroblasts cultured from @entity3179 display characteristics of senescence and have reduced growth rates. Susceptibility of young fibroblasts to the microcirculatory changes associated with @entity3179 , such as macrophage trapping and activation, could explain the prevalence of senescent fibroblasts in these wounds. METHODS: We tested the in vitro effect of @entity3179 wound fluid (VUWF), as well as pro-inflammatory cytokines known to be present in VUWF ( @entity310 , @entity1356 , and @entity2533 ), on neonatal foreskin fibroblasts (NFFs). NFF growth rates, cellular morphology, and senescence-associated @entity7791 (SA-beta-Gal) activity were determined in the presence or absence of VUWF and the above cytokines. VUWF @entity310 concentration and the effect of anti- @entity310 antibody on VUWF inhibitory activity were determined in samples obtained from four @entity1 with @entity3179 . RESULTS: NFF growth rates were significantly reduced by VUWF (42,727 +/- 6301 vs 3902 +/- 2191 P =. 006). @entity310 also significantly reduced NFF growth rates in a dose-dependent manner (P =.01). No significant growth-inhibitory activity was seen for @entity1192 or @entity2533 . Incubation with VUWF significantly increased the percentage of SA-beta-Gal-positive fibroblasts in vitro on culture day 12 (P =.02). @entity310 and @entity2533 had similar effects. @entity310 was detected in all VUWF tested, with a mean of 254 +/- 19 pg/mL. CONCLUSION: These data suggest that the @entity3179 microenvironment adversely affects young, rapidly proliferating fibroblasts such as NFFs and induces fibroblast senescence. Pro-inflammatory cytokines such as @entity310 and @entity2533 might be involved in this process. The role of other unknown inhibitory mediators, as well as pro-inflammatory cytokines, in @entity3179 development and @entity73 must be considered.

title: The proliferative capacity of neonatal skin fibroblasts is reduced after exposure to XXXX wound fluid: A potential mechanism for senescence in @entity3179 .

entities_list: @entity7791 :: ('MESH:D016537', 'Disease') :: ['beta-galactosidase']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired healing']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcers', 'venous ulcer']

answer: @entity3179 :: (MESH:D014647,Disease) :: ['venous ulcer']


abstract: @entity5 with abundant neuropil and true rosettes (ETANTR) is a @entity146 with unique histologic and molecular features occurring in very young @entity1 . At present approximately 80 cases of ETANTR have been documented in the literature since first description in 2000. We report seven @entity1 with ETANTR below 4 years of age who underwent surgical resection in the Burdenko Neurosurgery Institute between 2005 and 2010. Four @entity1 have received different modality chemotherapy and radiotherapy and two @entity1 were treated by chemotherapy alone. One @entity1 did not receive any adjuvant treatment. All @entity1 had local relapses, two of them were operated twice. A 2 year old @entity1 underwent subtotal resection thrice. Histological examination showed that all @entity5 were composed of true multilayered rosettes admixed with large areas of paucicellular neuropil. By analysis of recurrences we have found that large areas of neuropil and number of true rosettes were lost and @entity5 acquired a resemblance to central nervous system primitive @entity4969 . In four cases frozen @entity5 material was available for array-based comparative genomic hybridization, which discovered trisomy of chromosome 2 and amplification at the 19q13.42 chromosome locus. Fluorescence in situ hybridization revealed amplification at the 19q13.42 chromosome locus in all cases.

title: [A new entity in WHO classification of XXXX with abundant neuropil and true rosettes: case report and review of literature].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Embryonic tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girl', 'patients', 'child']

entities_list: @entity4969 :: ('MESH:D017599', 'Disease') :: ['neuroectodermal tumors']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['very aggressive rare tumor']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumors of the central nervous system--embryonic tumor']


abstract: OBJECTIVE: General malnutrition usually occurs in @entity63 ( @entity63 ) @entity1 because of shortness of appetite and @entity22 leaded by @entity1118 . And amputation frequently is end-point of @entity63 @entity1 . So the aim of this study was to assess the predictive ability of Geriatric nutritional risk index (GNRI) for predicting amputation in @entity1 with @entity63 . METHODS: A retrospective study was designed. Demographics, history, comorbidity, and risk factors for @entity1095 of admitted @entity1 , and laboratory study were documented. @entity1 ' height, weight and BMI were recorded. Amputation was identified as end-point during follow-up. @entity1 ' amputation-free survival (AFS) was recorded. RESULT: 172 @entity1 were identified, with mean age 71.98  3.12. Geriatric nutritional risk index (GNRI) = 90 was taken as cutoff value of high risk of amputation for @entity63 @entity1 via using receiver operating characteristic (ROC) curve. Span of follow-up was 12-48 months. During follow-up, 60 @entity1 (36.04%) received amputation surgery. And analyzed by Cox proportional hazards model, it is found that GNRI was the independent predictive factor for amputation in long term. CONCLUSION: This study revealed that GNRI was a reliable and effective predictive marker for AFS. GNRI could identify @entity1 with high risk for amputation in early time.

title: Geriatric Nutritional Risk Index (GNRI) Independently Predicts Amputation XXXX ( @entity63 ).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia', 'CLI']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['sleeplessness']

answer: @entity63 :: (MESH:D007511,Disease) :: ['Inchronic Criticallimb Ischemia']


abstract: BACKGROUND: The pathophysiological background of catecholaminergic polymorphic @entity1165 is well understood, but the clinical features of this stress-induced @entity74 , especially the incidence and risk factors of arrhythmic events, have not been fully ascertained. METHODS AND RESULTS: The outcome in 101 catecholaminergic polymorphic @entity1165 @entity1 , including 50 probands, was analyzed. During a mean follow-up of 7.9 years, @entity299 defined as @entity1163 , aborted @entity1167 , including appropriate discharges from implantable defibrillators, or @entity1164 occurred in 27 @entity1 , including 2 mutation carriers with normal exercise tests. The estimated 8-year event rate was 32% in the total population and 27% and 58% in the @entity1 with and without beta-blockers, respectively. Absence of beta-blockers (hazard ratio [HR], 5.48; 95% CI, 1.80 to 16.68) and younger age at diagnosis (HR, 0.54 per decade; 95% CI, 0.33 to 0.89) were independent predictors. Fatal or near-fatal events defined as aborted @entity1167 or @entity1164 occurred in 13 @entity1 , resulting in an estimated 8-year event rate of 13%. Absence of beta-blockers (HR, 5.54; 95% CI, 1.17 to 26.15) and history of aborted @entity1167 (HR, 13.01; 95% CI, 2.48 to 68.21) were independent predictors. No difference was observed in cardiac and fatal or near-fatal event rates between probands and family members. CONCLUSIONS: Cardiac and fatal or near-fatal events were not rare in both catecholaminergic polymorphic @entity1165 probands and affected family members during the long-term follow-up, even while taking beta-blockers, which was associated with a lower event rate. Further studies evaluating concomitant therapies are necessary to improve outcome in these @entity1 .

title: Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['arrhythmic disorder']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity1165 :: (MESH:D017180,Disease) :: ['ventricular tachycardia']


abstract: CT morphology of malignant pathologies of the stomach was evaluated by filling the stomach with water. Fifty-three @entity1 were examined who were affected with @entity189 , and 12 with @entity706 . @entity189 either determined parietal thickening of 7 mm to 3 cm or appeared as endoluminal vegetations with a big implant base. Neoplastic tissue had higher density than adjacent gastric wall in 80% of the cases, and the same density in the extant 20%. Only @entity189 appeared as isodense, the other histological types being hyperdense. The @entity1 with @entity6595 presented with small endoluminal vegetations or parietal thickening of 6 mm to 2 cm. @entity2617 had lower density than normal adjacent gastric wall in 65% of the cases, and the same density in the extant 35%. CT allowed even small lesions to be identified in malignant @entity1819 ; nonetheless, the method is to be considered a complementary technique to conventional radiology or endoscopy. The attenuation value of parietal alterations helps distinguish @entity356 from @entity706 , because of the hyperdense/hypodense aspect of the lesion. On the contrary, a @entity356 or @entity706 cannot be diagnosed when the @entity5 has the same density as adjacent gastric wall.

title: [The CT aspects and pathological correlations in @entity356 and XXXX ].

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'lymphomas']

entities_list: @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric lymphoma']

entities_list: @entity2617 :: ('MESH:D017254', 'Disease') :: ['Lymphomatous infiltrates']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric diseases']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['mucinous carcinomas', 'Carcinomas', 'carcinoma']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinomas', 'gastric carcinoma']

answer: @entity706 :: (MESH:D008223,Disease) :: ['lymphoma']


abstract: <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Hypoglycaemia is a serious adverse effect of antidiabetic drug therapy. We aimed to determine incidence rates of hypoglycaemia in type-2 diabetic @entity164 ent @entity6 e @entity1 edictors of hypoglycaemia when treatment is intensified. METHODS: DiaRegis is a prospective German registry that follows 3810 patients with ty @entity1 betes @entity164 rre @entity6 eatment intensification because of insufficient glycaemic control on one or two oral antidiabetic drugs. RESULTS: Out of a total of 3347 patients with da @entity1 able for the present analysis 473 (14.1%) presented any severity hypoglycaemia over a follow-up of 12 months. 0.4% were hospitalized (mean of 1.3  0.6 episodes), 0.1% needed medical assistance (1.0  0.0), 0.8% needed any help (1.1  0.5) and 10.1% no help (3.4  3.7), and 8.0% had no specific symptoms (3.6  3.5). Patients with in @entity1 ypoglycaemia had longer diabetes @entity6 nd a more frequent smoking history; more had co-morbid disease conditions such as coronary artery @entity453 erial disease @entity455 art failure, p @entity712 ro @entity1897 op @entity6 relevant depression at ba @entity308 ltivariable adjusted positive predictors of incident hypoglycaemia over the follow-up were prior anamnestic hypoglycaemia, retinopathy, dep @entity989 su @entity308 d blood glucose self-mea @entity413 t, but not sulfonylurea use @entity4136 ly reported for anamnestic or recalled hypogylcaemia. On the contrary, glitazones, DPP- @entity12721 rs @entity5735 GLP-1 analogues @entity6757 associated with a reduced risk of hypoglycaemia. CONCLUSIONS: Hypoglycaemia is a frequent adverse effect in ambulatory patients when antidiabetic treatment is intensified. Particular attention is warranted in patients with pr @entity1 odes of hypoglycaemia, microvascular di @entity66 athy and @entity989 receivi @entity1 in. On the other hand glitazones, DPP- @entity12721 rs @entity5735 GLP-1 analogues @entity6757 ssociated with a reduced risk.

title: Incidence and predictors of hypoglycaemia in XXXX 2 @entity6 - an analysis of the prospective DiaRegis registry.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial disease']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['longer diabetes duration', 'diabetic', 'diabetes', 'diabetic retinopathy']

entities_list: @entity4136 :: ('CHEBI:26831', 'Chemical') :: ['sulfonylurea']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['microvascular disease']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity12721 :: ('MESH:D045162', 'Chemical') :: ['glitazones']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: BACKGROUND: @entity4822 are common among professional hockey players in the @entity26421 ( @entity26421 ). HYPOTHESIS: Professional hockey players will return to a high level of function and ice hockey after arthroscopic labral repair and treatment of @entity1743 . STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Twenty-eight professional hockey players ( @entity26421 ) were unable to perform at the professional level due to unremitting and debilitating @entity158 . Players underwent arthroscopic labral repair and were treated for @entity1743 from March 2005 to December 2007. Players who had bilateral hip symptoms were excluded. Athletes completed the Modified Harris Hip Score preoperatively and postoperatively and also completed a @entity1 satisfaction questionnaire postoperatively. Return to sport was defined as the player resuming skating for training or participation in the sport of ice hockey. RESULTS: The average age at the time of surgery was 27 years (range, 18-37). There were 11 left hips and 17 right hips. Player positions included 9 defensemen, 12 offensive players, and 7 goaltenders. All players had @entity75 that required repair. In addition, all @entity1 had evidence of @entity1743 at the time of surgery. The average time to return to skating/hockey drills was 3.4 months. The average time to follow-up was 24 months (range, 12-42). The Modified Harris Hip Score improved from 70 (range, 57-100) preoperatively to an average of 95 (range, 74-100) at follow-up. The median @entity1 satisfaction was 10 (range, 5-10). Two players had reinjury and required additional hip arthroscopy. CONCLUSION: Treatment of @entity1743 and @entity75 in professional hockey players resulted in successful outcomes, with high @entity1 satisfaction and prompt return to sport.

title: Arthroscopic labral repair and treatment of XXXX in professional hockey players.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['labral lesions']

entities_list: @entity1743 :: ('MESH:D057925', 'Disease') :: ['femoroacetabular impingement']

entities_list: @entity26421 :: ('MESH:C537134', 'Disease') :: ['NHL', 'National Hockey League']

entities_list: @entity4822 :: ('MESH:D025981', 'Disease') :: ['Hip injuries']

answer: @entity1743 :: (MESH:D057925,Disease) :: ['femoroacetabular impingement']


abstract: This study was undertaken to determine whether in vitro treatment of @entity2 (3LL) cells with ultraviolet (UV) radiation could increase their immunogenicity. @entity5 cells were irradiated with UV light from a germicidal lamp (254 nm; UV-C) at a dose of 720 J/sq m. After 2 weeks of culture, the surviving cell population was cloned by limiting dilution. Cell suspensions of each clone were injected intrafootpad in C57BL/6 @entity19 at a dose of 2.5 X 10(5) cells per @entity19 . Eighty independent clones were tested. Fifty-one clones showed decreased tumorigenicity and failed to grow in 20 to 95% of immunocompetent @entity19 , whereas they produced @entity5 in 100% of irradiated (550 R) and athymic @entity19 . These clones were designated "tum-" (nontumorigenic) clones. In contrast, all 25 clones selected from the untreated parental 3LL induced progressively growing @entity5 in 100% of the @entity19 . After two courses of UV treatment, the uncloned 3LL population was rejected in 45% of inoculated @entity19 . @entity19 rejecting an inoculum of a tum- clone were completely resistant to subsequent challenge with higher doses of the same or unrelated tum- clones. This resistance was fully expressed even after irradiation of immune @entity19 with 550 R. @entity19 immune to a tum- clone also were able to prevent the growth of various tum+ clones or untreated 3LL @entity5 cells. When tum- and tum+ clone cells were simultaneously inoculated intrafootpad in opposite legs, rejection of tum- clone resulted also in the prevention of the growth of tum+ clone. Spleen cells of immune @entity19 caused rapid elimination of radiolabeled 3LL @entity5 cells from the place of their inoculation (intrafootpad) and prevented @entity5 growth. In an in vitro cytotoxic assay, spleen cells after in vivo and in vitro immunization with tum- clones demonstrated high cytotoxic activity against various tum+ clones and parental 3LL cells, as well as against tum- clones. In addition, parental 3LL @entity5 cells and tum- cells were similarly able to inhibit cytotoxic activity in the cold target inhibition assay. However, in contrast to tum- cells, 3LL cells were less efficient in in vitro restimulation of cytotoxic activity of immune spleen cells. Therefore, these data suggest that tum-, tum+, and parental 3LL cells share a common antigenic specificity, which is not immunogenic in 3LL cells. UV treatment presumably converted the antigenic determinants present in the 3LL cells into an immunogenic form.

title: Induction of highly immunogenic variants of @entity2 XXXX by ultraviolet irradiation.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Lewis lung carcinoma']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'nude mice', 'Mice']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: Elucidating the intracellular signaling cascades which lead to differentiation programs can be a daunting but necessary task. Even more so when the nature of the differentiating stimuli can elicit different biochemical responses yet achieve the same functional outcome. In the field of cartilage and bone regeneration the importance of the @entity3963 ( @entity3963 ) pathway has been a controversial issue as of late. Whether differentiation results from a soluble chemical induction or a microenvironmental cue on the cells seems to have a determining effect on the role that this pathway plays in ultimate cell fate. Here we explore the role of the @entity1366 pathway on the mechanical induction of chondrogenesis of bone marrow mesenchymal stem cells (MSC). The cells were encapsulated in fibrin gel scaffolds and subjected to a dynamic mechanical compression stimulus previously demonstrated to induce chondrogenic differentiation of the cells with and without the addition of @entity4286 , a selective inhibitor for the @entity1366 pathway. Samples were then analyzed by RT-PCR and histochemical staining for markers of both @entity421 . Our results show that dynamic compression induces the chondrogenic differentiation of the cells and that inhibition of the @entity1366 pathway completely abolishes this chondrogenic response. On the other hand, inhibition of @entity1366 under dynamic compression augments the osteogenic response of the cells and significantly increases their expression of @entity623 ( @entity623 ), collagen type I (COLI) and osteocalcin ( @entity12502 ) (P<0.05). These results were confirmed by the histochemical staining where dynamically compressed samples show staining for sulfated glycosaminoglycans (sGAG) while the inhibited and compressed samples show no sGAG but present positive staining for microcalcifications. These results would suggest that the activation of @entity1366 can determine the ultimate cell fate between the chondrogenic and osteogenic programs in cells stimulated under dynamic unconfined mechanical compression.

title: XXXX ( @entity3963 ) dictates osteogenic and/or chondrogenic lineage commitment of mesenchymal stem cells under dynamic compression.

entities_list: @entity3963 :: ('5594', 'Gene') :: ['extracellular signal-regulated kinase', 'ERK']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['chondrogenic and osteogenic differentiation']

entities_list: @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']

answer: @entity3963 :: (5594,Gene) :: ['Extracellular signal-regulated kinase']


abstract: OBJECTIVE: To recognize the clinical features of the enterovirus 71 (EV71) infection with @entity3126 or @entity548 as a fulminant and often fatal illness. METHODS: We retrospectively reviewed the medical records of the three cases with EV71 infection for clinical manifestation, laboratory data, medications, outcome etc. RESULTS: All the cases were @entity1 and they all died. These @entity1 had no skin or @entity3137 , however, they had sudden onset of @entity848 and @entity7405 1 to 2 days after the onset of the @entity66 with @entity391 . All these 3 cases were misdiagnosed and were treated for shock on admission. @entity548 was not considered in any of the cases on admission. All the cases received tracheal intubation when foamy secretions were discharged from mouth and nose of the @entity1 and notable @entity848 was noted. After intubation, all had pink foamy fluid flew out from the endotracheal tube. The @entity1 had @entity4854 and @entity425 , two had @entity591 , and @entity101 was found in one case. Chest X-ray showed bilateral or unilateral widespread air space opacity, but the cardiac size and shape were normal. All the @entity1 had leucocytosis. EV71 infection was confirmed by detection of specific sequences of the virus in throat swab and tracheal secretions samples and in one case in cerebrospinal fluid sample. CONCLUSION: @entity3126 or @entity548 occurred in the 3 cases with EV71-infected @entity1 . The initial presentation was often nonspecific with @entity221 and @entity391 , and @entity2459 , @entity7405 , @entity591 , @entity101 or @entity551 , @entity425 may suggest @entity3126 or @entity548 . Excessive fluid resuscitation may deteriorate the illness, on the contrary, fluid restriction and inotropic agents, and early intubation with positive pressure mechanical ventilation may be the proper treatment.

title: [Three cases of enterovirus 71 infection with XXXX or @entity548 as the early clinical manifestation].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['febrile disease']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema', 'Pulmonary edema']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['pulmonary hemorrhage', 'Pulmonary hemorrhage', 'hemorrhage']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['limb weakness']

entities_list: @entity7405 :: ('MESH:D059246', 'Disease') :: ['tachypnea']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']

entities_list: @entity848 :: ('MESH:D003490', 'Disease') :: ['cyanosis']

entities_list: @entity2459 :: ('MESH:D003639', 'Disease') :: ['sudden appearances of cyanosis']

answer: @entity3126 :: (MESH:D011654,Disease) :: ['pulmonary edema']


abstract: We assessed the antimicrobial resistance patterns of all urine samples submitted for culture from outpatient @entity1 aged >= 14 years with diagnosis of uncomplicated @entity2335 over a 24-month period (2007-2009) in the city of Fortaleza, Brazil. Only bacterial growth of a single uropathogen with >= 10(5) CFU/mL was considered for analysis. The Pearson's chi-square test was used for bivariate correlations. @entity526 presented the highest prevalence (64.7%). Coagulase-negative staphylococcus was more common in younger than in older @entity1 (P = 0.003). @entity801 presented the lowest overall resistance pattern (3.5% resistant), followed by @entity2756 (5%) and @entity4258 (7.5%). @entity869 and @entity799 were the least active agents with 63.7% and 39.8% of resistance, respectively. The resistant rate to @entity799 was significantly higher among @entity526 than non- @entity526 isolated. Among @entity2177 -resistant @entity526 strains, only 3.4% were resistant to @entity6616 . We conclude that @entity799 follows a worldwide tendency of antimicrobial increasing resistance and it should be avoided as first-line empirical treatment for @entity293 .

title: Antimicrobial resistance of uropathogens in @entity1 with acute uncomplicated XXXX from primary care settings.

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['Gentamicin']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity6616 :: ('MESH:D009582', 'Chemical') :: ['nitrofurantoin']

entities_list: @entity4258 :: ('MESH:D009643', 'Chemical') :: ['norfloxacin']

entities_list: @entity799 :: ('MESH:D015662', 'Chemical') :: ['trimethoprim-sulfamethoxazole']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['Ampicillin']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity2335 :: (MESH:D003556,Disease) :: ['cystitis']


abstract: BACKGROUND: Studies of diagnostic practice confirm that there is a diagnostic delay in diagnosing @entity1 with @entity161 compared to diagnosing @entity1 . The aim of the present study was to investigate the diagnostic practice of Norwegian and Russian psychiatrists when it comes to early @entity716 , emphasising gender differences. We wanted to study the association between @entity1 gender as such and diagnostic decision-making among psychiatrists. MATERIALS AND METHODS: Psychiatrists in Norway and the Archangels region in Russia were invited to participate in a study of diagnostic practice, and received a written case description of a @entity1 with early @entity716 symptoms that could be interpreted as @entity161 . They were, however, not informed that 50% of them received a female case description and 50% a male case description. Apart from the @entity1 being described as "he" or "she" the stories were identical. Effects of @entity1 gender, clinician gender, age and main area of interest were estimated using logistic regression analysis. RESULTS: A total of 467 psychiatrists answered the questionnaire. We found that @entity161 diagnosis was given significantly more often to the male case than to the female case. Our finding remained significant after adjustment for country, clinician gender, age and main area of interest, and is unlikely to be explained by known biases. CONCLUSION: @entity1 gender in itself affects clinicians' diagnostic practice regarding @entity161 , as @entity161 diagnosis is given significantly more often to a male case description than to a female one, the descriptions being otherwise identical.

title: The effect of gender in diagnosing early XXXX --an experimental case simulation study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'Patient', 'men']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: The @entity6402 'complex' (Bcc) presently comprises nine species and genomovars. In order to acquire a better comprehension of the species and genomovar distribution and of the genetic diversity among environmental Bcc bacteria, a natural population of 60 bacterial isolates recovered from the rhizosphere of @entity2829 and belonging to the Bcc has been characterised to assess the exact taxonomic position, the genetic polymorphism and the metabolic profiles of isolates. The identification of the different species and genomovars was accomplished by a combination of techniques including @entity3208 - @entity2975 gel electrophoresis of whole-cell proteins and recA-based restriction fragment length polymorphism analyses. The genetic diversity among Bcc isolates was analysed by means of the random amplified polymorphic DNA and amplified fragment length polymorphism techniques; the analysis of molecular variance method was applied to estimate the genetic differences among the various species and genomovars identified within the bacterial population. Metabolic profiles based on @entity505 source utilisation were obtained by means of the Biolog GN assay and analysed by means of cluster analysis. Forty-four strains were identified as @entity9182 , 11 as @entity7081 recA lineage III-B, four as B. pyrrocinia, and one as @entity6402 genomovar I. Marked genetic differences were observed between @entity7081 and @entity9182 , whereas limited differences were found between B. pyrrocinia and @entity9182 and between B. pyrrocinia and @entity7081 . No significant differences (P>0.05) were observed between the mean genetic distances of isolates belonging to @entity7081 , @entity9182 , and B. pyrrocinia. Phenotypic analyses revealed that all isolates tested were able to utilise more than 75% of substrates. The highest variability in the number of utilised substrates was found among @entity7081 isolates, whereas the lowest was found among @entity9182 isolates. Cluster analysis of metabolic profiles revealed pronounced differences between @entity7081 and @entity9182 ; in contrast, B. pyrrocinia could not be clearly separated either from @entity7081 or from @entity9182 .

title: A rhizospheric XXXX complex population: genotypic and phenotypic diversity of @entity7081 and @entity6402 ambifaria.

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity6402 :: ('292', 'Species') :: ['B. cepacia', 'Burkholderia cepacia']

answer: @entity6402 :: (292,Species) :: ['Burkholderia cepacia']


abstract: INTRODUCTION: @entity5 represent a great therapeutic challenge. Previous papers have documented good results from Gamma Knife surgery (GKS) with these @entity5 . However, the relationship between clinical improvement and @entity5 shrinkage has never been assessed. MATERIALS AND METHODS: There were 14 @entity1 , 9 @entity1 and 5 @entity1 . The mean follow-up period was 28 months (range 6 to 60 months). All the @entity5 except one were Fisch type D and the mean volume was 14.2 cm(3) (range 3.7-28.4 cm(3)). The mean prescription dose was 13.6 Gy (range 12-16 Gy). RESULTS: None of the @entity5 have continued to grow. Eight are smaller and 6 unchanged in volume. Two @entity1 with bruit have had no improvement in their symptoms. Among the other 12 @entity1 , 5 have had symptomatic improvement of @entity1282 , 4 in @entity7364 , 3 in facial numbness, 3 in ataxia and 2 in @entity392 . Individual @entity1 have experienced improvement in @entity391 , vertigo, @entity2901 , hearing, @entity10 , @entity3541 and accessory paresis. One @entity1 developed a transient @entity3541 . Symptomatic improvement commonly began before any reduction in @entity5 volume could be detected. The mean time to clinical improvement was 6.5 months whereas the mean time to shrinkage was 13.5 months. CONCLUSIONS: Gamma Knife treatment of glomus jugulare @entity5 is associated with a high incidence of clinical improvement with few complications, using the dosimetry recorded here. Clinical improvement would seem to be a more sensitive early indicator of therapeutic success than radiological volume reduction. Further follow-up will be needed.

title: XXXX : certain clinical and radiological aspects observed following Gamma Knife radiosurgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Glomus jugulare tumours', 'tumours', 'tumour']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity7364 :: ('MESH:D055154', 'Disease') :: ['dysphonia']

entities_list: @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial palsy']

entities_list: @entity2901 :: ('MESH:D005207', 'Disease') :: ['tongue fasciculation']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Glomus jugulare tumours']


abstract: OBJECTIVE: To summarise the adverse events (AE) reported in @entity1 with @entity309 ( @entity309 ) treated with protein kinase inhibitors (PKi), and identify family and molecule-related AEs. METHODS: Systematic review of the PKi used in clinical trials (CTs) in @entity309 . Medline, Embase, Cochrane Library, Web of Knowledge, and international abstracts of congress were reviewed, (up to 31 October 2012). Search was limited to interventional studies of PKi used in CTs in @entity309 , written in English, and reporting frequencies of AE. Diseases with similar comorbidity burden also were included. Frequency of AE, serious AE (SAE), @entity204 and discontinuation due to   AEs (DCAE) were recorded. Risk of bias was assessed. Meta-analysis was carried using pooled relative risk (RR) with 95% CI as effect measure. RESULTS: The search produced 4410 hits. Forty-one articles reporting data on 21 PKi of the Janus kinase (JAK), @entity10255 , @entity1435 and cKit families were selected for detailed analysis. In @entity1 treated with @entity1435 inhibitors, RR for dizziness was 2.36 (1.20 to 4.63), and in @entity1 treated with @entity2467 inhibitors, RR for @entity4 was 3.43 (1.58 to 7.42). In @entity1 treated with the JAK inhibitor @entity16826 , RR for hypercholesterolaemia was 1.70 (1.10 to 2.63) that was dose related. In @entity1 treated with the @entity10255 inhibitor @entity30210 , pooled RR for hypertransaminasaemia, @entity101 , @entity294 and @entity1398 were 2.93 (1.02 to 8.43), 2.80 (1.58 to 5.99), 5.20 (3.19 to 8.49) and 9.24 (2.22 to 38.42), respectively. Serious infections and @entity5 were not significantly more frequent in PKi-treated @entity1 than in comparator groups. CONCLUSIONS: Event rates of serious infections and @entity5 with PKi are not different from biologics. In addition, PKi have a unique safety profile related to target and off-target inhibition of kinases, at times dose related.

title: Safety profile of protein kinase inhibitors in XXXX : systematic review and meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity16826 :: ('MESH:C479163', 'Chemical') :: ['tofacitinib']

entities_list: @entity30210 :: ('MESH:C523665', 'Chemical') :: ['fostamatinib']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: Complications during treatment of seriously injured @entity130 @entity1 cause an increase in mortality rates, and increased treatment costs, including bed occupancy. Current methods treat those at risk, and include numbers of false positives. By finding a method to predict those at risk of the three most common recorded @entity130 Registry complications, considerable savings in mortality and treatment costs could arise. Artificial Neural Networks (ANN) work well with classification problems using feed-forward/back propagation methodology. Using the National @entity130 Data Bank (V6.2) data files, Tiberius Software created the ANN models. Best models were identified by their Gini co-efficient, ability to predict the complication outcome selected, and their Root Mean Squared Error (RMSE) scores. The model ensemble for the three major complications recorded in the registry were determined, variables ranked and model accuracy recorded. The basic ANN is fairly accurate for those likely to contract @entity6185 ( @entity6185 ) though with a high rate of false positives. The ANN ability to predict @entity2489 ( @entity2489 ) is less effective, though better at producing fewer false positives. Predicting @entity293 ( @entity293 ) cases is not good enough using these input variables. Both @entity2489 and @entity293 relate to those aged over 55 years, while @entity6185 related more to those under 16 years. The models need improving.

title: Using artificial neural networks to predict potential complications during @entity130 XXXX ' hospitalization period.

entities_list: @entity6185 :: ('MESH:D045169', 'Disease') :: ['ARDS', 'Acute Respiratory Disease Syndrome']

entities_list: @entity2489 :: ('MESH:D053717', 'Disease') :: ['VAP', 'Ventilator Associated Pneumonia']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['Urinary Tract Infections', 'UTI']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: This is the first study to investigate how actively engaged and vigorous @entity1 remain in their life tasks in the midst of chronic exposure to significant traumatic events. We sought to identify risk and protective factors for engagement within the context of ongoing exposure to political violence and social upheaval. We randomly identified and interviewed 1,196 adult residents of the West Bank and Gaza during a period of violent conflict on 3 occasions: (1) September-October 2007, (2) April-May 2008, and (3) October-November 2008. @entity1 were asked about their exposure to political violence, symptoms of @entity308 , and posttraumatic stress (PTS) symptoms, their level of social support, psychosocial resource loss, and positive engagement in life tasks. Path modeling revealed that @entity130 exposure indirectly affected engagement through its impact on resource loss and PTS and @entity308 symptoms. PTS symptoms at @entity13831 were modestly related to greater engagement at @entity27399 , and @entity308 symptoms did not independently predict engagement at @entity27399 . Psychosocial resource loss at @entity13830 and @entity13831 was the best overall predictor of engagement at @entity27399 , through its direct and indirect effects via PTS symptoms. Greater engagement was also predicted by greater social support, being more educated, being younger, and being more religious. The relative independence of @entity458 and engagement was noted as a critical finding supporting a key tenet of positive psychology. The relationship of resource loss and social support with engagement suggests that bolstering psychosocial resources may offer a route for primary and secondary prevention amidst chronic traumatic conditions.

title: Can XXXX remain engaged and vigorous in the face of @entity130 ? Palestinians in the West Bank and Gaza.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: Perception of biological motion is linked to the action perception system in the @entity1 brain, abnormalities within which have been suggested to underlie impairments in social domains observed in @entity2438 spectrum conditions (ASC). However, the literature on biological motion perception in ASC is heterogeneous and it is unclear whether deficits are specific to biological motion, or might generalize to form-from-motion perception. METHODOLOGY AND PRINCIPAL FINDINGS: We compared psychophysical thresholds for both biological and non-biological form-from-motion perception in adults with ASC and controls. @entity1 viewed point-light displays depicting a walking @entity1 (Biological Motion), a translating rectangle (Structured Object) or a translating unfamiliar shape (Unstructured Object). The figures were embedded in noise dots that moved similarly and the task was to determine direction of movement. The number of noise dots varied on each trial and perceptual thresholds were estimated adaptively. We found no evidence for an impairment in biological or non-biological object motion perception in individuals with ASC. Perceptual thresholds in the three conditions were almost identical between the ASC and control groups. DISCUSSION AND CONCLUSIONS: Impairments in biological motion and non-biological form-from-motion perception are not across the board in ASC, and are only found for some stimuli and tasks. We discuss our results in relation to other findings in the literature, the heterogeneity of which likely relates to the different tasks performed. It appears that individuals with ASC are unaffected in perceptual processing of form-from-motion, but may exhibit impairments in higher order judgments such as emotion processing. It is important to identify more specifically which processes of motion perception are impacted in ASC before a link can be made between @entity51 and the higher-level features of the disorder.

title: Unaffected perceptual thresholds for biological and non-biological form-from-motion perception in XXXX spectrum conditions.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'Participants', 'person']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['perceptual deficits']

answer: @entity2438 :: (MESH:D001321,Disease) :: ['autism']


abstract: BACKGROUND: @entity1468 is associated with an increased risk of development of @entity65 later in life. It is not known how general practitioners in the Netherlands care for these @entity1 after delivery with respect to @entity65 factor management. METHODS: Review of medical records of 1196 @entity1 in four primary health care centres, who were registered from January 2000 until July 2007 with an International Classification of Primary Care (ICPC) code indicating pregnancy. Records were searched for indicators of @entity1468 . Of those who experienced @entity1468 and of a random sample of 150 @entity1 who did not, the following information on @entity65 factor management after pregnancy was extracted from the records: frequency and timing of blood pressure, @entity165 and @entity413 measurements--and vascular diagnoses. Additionally the sensitivity and specificity of ICPC coding for @entity1468 were determined. RESULTS: 35 @entity1 experienced @entity1468 . Blood pressure was more often checked after pregnancy in these @entity1 than in controls (57.1% vs. 12.0%, p<0.001). In 50% of the cases blood pressure was measured within 3 months after delivery with no further follow-up visit. A check for @entity413 and @entity165 levels was rare, and equally frequent in PE and control @entity1 . 20% of the previously normotensive @entity1 in the PE group had @entity101 at one or more occasions after three months post partum versus none in the control group. The ICPC coding for @entity1468 showed a sensitivity of 51.4% and a specificity of 100.0%. CONCLUSION: Despite the evidence of increased risk of future @entity65 in @entity1 with a history of @entity1468 , follow-up of these @entity1 is insufficient and undeveloped in primary care in the Netherlands.

title: @entity65 factor assessment after XXXX in primary care.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia', 'Pre-eclampsia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease', 'cardiovascular risk']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1468 :: (MESH:D011225,Disease) :: ['pre-eclampsia']


abstract: @entity750 ( @entity750 ) plays an important role in shaping the activity of the spinal networks underlying locomotion in many vertebrate preparations. At larval stages in @entity3392 , @entity750 does not change the frequency of spontaneous swimming; and it only decreases the quiescent period between consecutive swimming episodes. However, it is not known whether @entity750 exerts similar actions on the locomotor network at later developmental stages. For this, the effect of @entity750 on the fictive locomotor pattern of juvenile and adult @entity3392 was analyzed. Bath-application of @entity750 (1-20 mum) reduced the frequency of the @entity143 -induced locomotor rhythm. Blocking removal from the synaptic cleft with the reuptake inhibitor @entity837 had similar effects, suggesting that endogenous @entity750 is modulating the locomotor pattern. One target for this modulation was the mid-cycle inhibition during locomotion because the IPSPs recorded in spinal neurons during the hyperpolarized phase were increased both in amplitude and occurrence by @entity750 . Similar results were obtained for IPSCs recorded in spinal neurons clamped at the reversal potential of excitatory currents (0 mV). @entity750 also slows down the rising phase of the excitatory drive recorded in spinal cord neurons when glycinergic inhibition is blocked. These results suggest that the decrease in the locomotor burst frequency induced by @entity750 is mediated by a potentiation of mid-cycle inhibition combined with a delayed onset of the subsequent depolarization.

title: Serotonergic modulation of locomotion in XXXX : endogenous release and synaptic mechanisms.

entities_list: @entity837 :: ('MESH:D015283', 'Chemical') :: ['citalopram']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin', 'Serotonin', '5-HT']

answer: @entity3392 :: (7955,Species) :: ['zebrafish']


abstract: Intraluminal high dose rate brachytherapy (ILHDR BT) is one of several effective modalities for palliation of advanced @entity418 . Thirty @entity1 with endoscopic-proven, mostly locally advanced, @entity957 of the esophagus, not involving the gastroesophageal junction and without distant metastases, were included in this analysis. Twenty-nine @entity1 received two ILHDR BT sessions of 8 Gy within a week and one @entity1 received only one session. All @entity1 were followed monthly. Outcomes included quality of life (QOL), symptoms control: @entity1282 , @entity338 , odynophagia, and @entity662 , as well as, overall survival. Through 4 months of follow-up, QOL was statistically improved (having lowered scores) in regards to feelings (P= 0.013), sleeping (P= 0.032), eating (P= 0.020), and social life (P= 0.002). The most significantly improved symptom was @entity1282 (P < 0.006), with a reduction of 0.52 units or one-half grade. @entity338 , odynophagia, and @entity158 were lower during follow-up but were not statistically significant. The median overall survival from death of any cause was 165 days (with a 95% confidence interval of 128-195 days). In conclusion, ILHDR BT of advanced squamous @entity418 consisting of two out- @entity1 procedures is very successful in achieving the primary objectives of the @entity1 to reduce @entity1282 and improve QOL.

title: Intraluminal brachytherapy in the management of XXXX of the esophagus.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest or back pain']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['Regurgitation', 'regurgitation']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous carcinoma']


abstract: BACKGROUND: Deviations from nominal alignment of unicondylar knee replacements impact knee biomechanics, including the load and stress distribution at the articular contact surfaces. This study characterizes relationships between the biomechanical environment, distinguished by progressive changes in alignment and fixation, and @entity16 and deformation in a consecutive series of retrieved unicondylar knee replacements. METHODS: Twenty seven fixed-bearing, non-conforming unicondylar knee replacements of one design were retrieved after 2 to 13 years of in vivo function. The in vivo biomechanical environment was characterized by grading component migration measured from full-length radiographs and grading component fixation based on intraoperative manual palpation. @entity16 patterns and linear deformation on the @entity691 inserts were measured using optical photogrammetry and contact point digitization. FINDINGS: @entity16 patterns and surface deformation on the explanted @entity691 inserts corresponded to progressive changes in component alignment and fixation. Component migration produced higher deformation rates, whereas loosening contributed to larger damage areas but lower deformation rates. Migration and loosening of the femoral component, but not the tibial component, were factors contributing to large regions of abrasion concentrated on the articular periphery. INTERPRETATION: Classifying component migration and fixation at revision proved useful for distinguishing common biomechanical conditions associated with the varied @entity691 damage patterns and linear deformation for this fixed-bearing, non-conforming design. Pre-clinical evaluations of unicondylar knee replacements that are capable of reproducing variations in clinical alignment and predicting the observed wear mechanisms are necessary to better understand the impact of knee biomechanics and design on unicondylar knee replacement longevity.

title: XXXX damage and deformation on fixed-bearing, non-conforming unicondylar knee replacements corresponding to progressive changes in alignment and fixation.

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['polyethylene']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['articular damage', 'Articular damage']

answer: @entity691 :: (MESH:D020959,Chemical) :: ['Polyethylene']


abstract: Therapeutic strategies such as using channel blockers and reducing culture temperature have been used to rescue some long QT-associated voltage-gated @entity972 Kv trafficking defective mutant channels. A hyperpolarization-activated cyclic @entity377 -gated @entity26039 pacemaker channel mutant ( @entity31910 ) has been recently found in a @entity1 associated with @entity943 including long QT. @entity31910 showed the defective trafficking to the cell surface, leading to little ionic current expression (loss-of-function). We show in this report that enhanced @entity669 phosphorylation mediated by @entity7242 , @entity7984 , and Yes kinases was able to restore the surface expression of @entity31910 for normal current expression. @entity7242 or Yes, but not @entity7984 , significantly increased the current density and surface expression of @entity31910 . @entity7984 accelerated the activation kinetics of the rescued @entity31910 . Co-expression of @entity31910 with Yes exhibited the slowest activation kinetics of @entity31910 . @entity7242 , @entity7984 , and Yes significantly enhanced the @entity669 phosphorylation of @entity31910 . A combination of @entity7242 , @entity7984 , and Yes rescued the current expression and the gating of @entity31910 comparable with those of wild-type @entity26039 . In conclusion, we demonstrate a novel mechanism using three endogenous @entity7242 kinases to rescue a trafficking defective @entity26039 mutant channel ( @entity31910 ) by enhancing the @entity669 phosphorylation of the mutant channel protein.

title: Rescue of a trafficking defective @entity1 pacemaker channel via a novel mechanism: roles of @entity7242 , XXXX , and Yes @entity669 kinases.

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias']

answer: @entity7984 :: (2534,Gene) :: ['Fyn']


abstract: BACKGROUND: Efflux pump activity has been associated with multidrug resistance phenotypes in bacteria, compromising the effectiveness of antimicrobial therapy. The development of methods for the early detection and quantification of drug transport across the bacterial cell wall is a tool essential to understand and overcome this type of drug resistance mechanism. This approach was developed to study the transport of the efflux pump substrate @entity5611 ( @entity25003 ) across the cell envelope of @entity2624 and derivatives, differing in the expression of their efflux systems. RESULTS: @entity25003 transport across the cell envelope of @entity2624 and derivatives was analysed by a semi-automated fluorometric method. Accumulation and efflux of @entity25003 was studied under limiting energy supply (absence of @entity413 and low temperature) and in the presence and absence of the efflux pump inhibitor, @entity2644 . The bulk fluorescence variations were also observed by single-cell flow cytometry analysis, revealing that once inside the cells, leakage of @entity25003 does not occur and that efflux is mediated by active transport. The importance of AcrAB-TolC, the main efflux system of @entity526 , in the extrusion of @entity25003 was evidenced by comparing strains with different levels of AcrAB expression. An experimental model was developed to describe the transport kinetics in the three strains. The model integrates passive entry (influx) and active efflux of @entity25003 , and discriminates different degrees of efflux between the studied strains that vary in the activity of their efflux systems, as evident from the calculated efflux rates: = 0.0173 +/- 0.0057 min-1; = 0.0106 +/- 0.0033 min-1; and = 0.0230 +/- 0.0075 min-1. CONCLUSION: The combined use of a semi-automated fluorometric method and an experimental model allowed quantifying @entity25003 transport in @entity526 strains that differ in their overall efflux activity. This methodology can be used for the early detection of differences in the drug efflux capacity in bacteria accounting for antibiotic resistance, as well as for expedite screening of new drug efflux inhibitors libraries and transport studies across the bacterial cell wall.

title: Fluorometric determination of @entity5611 efflux kinetics in XXXX .

entities_list: @entity5611 :: ('MESH:D004996', 'Chemical') :: ['ethidium bromide']

entities_list: @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine']

entities_list: @entity2624 :: ('83333', 'Species') :: ['Escherichia coli K-12', 'E. coli K-12']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']


abstract: PURPOSE OF REVIEW: @entity1 with @entity161 have higher than expected rates of morbidity and mortality. It is debatable whether this is related to shared risk factors, antipsychotic medication or inherent to the condition itself. This review will describe this association and the recent advances in the field. RECENT FINDINGS: The majority of @entity1 with @entity161 have at least one chronic comorbid medical condition. In the absence of systematic screening this may or may not be brought to the attention of health professionals. The cause of high rates of @entity221 appears to be multifactorial involving shared vulnerability and genetic factors. Yet it is vascular risk factors and the adverse effects of prescribed medication that are most amenable to intervention. Current atypical antipsychotics may offer @entity73 , but there is accumulating evidence of problems with @entity1017 , @entity6 , @entity10204 , @entity209 and @entity458 . SUMMARY: The physical health of @entity1 with @entity161 remains a concern. Yet the quality of medical and @entity146 care of @entity1 with comorbid physical and @entity146 has been shown to be unsatisfactory in several areas. We suggest that clinicians routinely assess and monitor physical health needs of @entity1 with serious @entity1032 .

title: Physical health and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'mental health disorders']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['neurological and cognitive benefits']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual side effects']

entities_list: @entity10204 :: ('MESH:D021081', 'Disease') :: ['lipid dysregulation']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['physical illness']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: Individual cases of adult @entity734 have surfaced repeatedly in the lay and professional literature of the past 1.5 centuries without it occasioning systematic investigation, such as the reporting of a case series of individuals subjected to such extreme abuse. Yet substantial numbers of @entity1 with @entity5748 at the time of presentation report @entity734 continuing into the adult years, and for many the abuse is ongoing. Data relating to a series of 10 such incestuously abused @entity1 are presented. These @entity1 were sexually abused from a very early age (typically from before age 3), with the manipulation of their sexual response a key component in conditioning an enduring sexualized attachment. Shame and fear were also used to ensure compliance and silence. The @entity1 , when able to speak of it, describe the induction by their paternal abuser of orgasm at an early age, typically around the age of 6. The @entity1 have high indices of self-harm and suicidality and are prone to placing themselves in dangerous reenactment scenarios. The average duration of @entity734 for this group of @entity1 was 31 years, and the average estimate of total episodes of @entity458 was 3,320. Most @entity1 do not feel that they own their body and experience being "fused" to their father. Their mother was reported as an active @entity1 in the @entity458 or as having done nothing to protect their daughter despite seeing obvious evidence of incest. The fathers, despite a propensity to use or threaten violence, were generally outwardly productively employed, financially comfortable, and stably married and half had close church involvement. However, suicide and murder occurred within the 1st- or 2nd-degree relatives of these @entity1 at a high frequency. All 10 had been sexually abused by various groupings of individuals connected to their fathers.

title: Ongoing XXXX during adulthood.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'participant']

entities_list: @entity5748 :: ('MESH:D009105', 'Disease') :: ['dissociative identity disorder']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['incestuous abuse']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse']

answer: @entity734 :: (MESH:D019966,Disease) :: ['incestuous abuse']


abstract: BACKGROUND: The treatment preserving the kidney for @entity3484 is still controversial. The indications and results of conservative treatment remain to be elucidated. Experiences of this type of treatment are reported. METHODS: Between April 1981 and March 1998, 14 @entity1 with upper @entity3484 were treated with renal preserving methods. Five were elective and nine were imperative cases. Treatments performed were partial nephrectomy, partial ureterctomy with or without adjuvant chemotherapy, endoscopic @entity5 resection and topical bacillus Calmette-Guerin instillation in one, 10, two and one @entity1 , respectively. RESULTS: Crude and cause-specific 5 year-survival rates were 91.7 and 100%, respectively. Of 14 @entity1 , five had bladder recurrences, but ipsilateral local recurrence developed in only one @entity1 . Two @entity1 died from @entity1606 61 and 89 months after initial treatment. The lesions of @entity2735 were well controlled with topical bacillus Calmette-Guerin therapy. CONCLUSION: The results of conservative treatment for @entity3484 were satisfactory and local excision can be indicated for low grade, @entity5 located in the distal ureter.

title: Results of conservative treatment of upper XXXX .

entities_list: @entity3484 :: ('MESH:D014571', 'Disease') :: ['upper urinary tract tumor', 'urinary tract transitional cell carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['carcinoma in situ']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'solitary tumors']

entities_list: @entity1606 :: ('MESH:D002295', 'Disease') :: ['metastasis of transitional cell carcinoma']

answer: @entity3484 :: (MESH:D014571,Disease) :: ['urinary tract transitional cell carcinoma']


abstract: Nine serologic types of avian paramyxovirus ( @entity26494 ) have been recognized. @entity7467 virus ( @entity26494 -1) is the most extensively characterized virus, while relatively little information is available for the other @entity26494 serotypes. In the present study, we examined the pathogenicity of two strains of @entity26494 -2, Yucaipa and Bangor, in 9-day-old embryonated @entity1573 eggs, 1-day-old specific-pathogen-free (SPF) chicks, and 4-wk-old SPF @entity1573 and @entity233 . The mean death time in 9-day-old embryonated @entity1573 eggs was more than 168 hr for both strains, and their intracerebral pathogenicity index (ICPI) was zero, indicating that these viruses are nonpathogenic in @entity1573 . When inoculated intracerebrally in 1-day-old chicks, neither strain caused disease or replicated detectably in the brain. This suggests that the zero ICPI value of @entity26494 -2 reflects the inability of the virus to grow in neural cells. Groups of twelve 4-wk-old SPF @entity1573 and @entity233 were inoculated oculonasally with either strain, and three birds per group were euthanatized on days 2, 4, 6, and 14 postinoculation for analysis. There were no overt clinical signs of illnesses, although all birds seroconverted by day 6. The viruses were isolated predominantly from the respiratory and alimentary tracts. Immunohistochemistry studies also showed the presence of a large amount of viral antigens in epithelial linings of respiratory and alimentary tracts. There also was evidence of systemic spread even though the cleavage site of the viral fusion glycoprotein does not contain the canonical furin protease cleavage site.

title: Pathogenesis of two strains of avian paramyxovirus serotype 2, Yucaipa and Bangor, in XXXX and @entity233 .

entities_list: @entity7467 :: ('MESH:D009521', 'Disease') :: ['Newcastle disease']

entities_list: @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken']

answer: @entity1573 :: (9031,Species) :: ['chickens']


abstract: A high dose-rate afterloading technique (60Co) was compared with a low dose-rate packing method (226Ra) in the treatment of @entity1204 stage I. In all, 1,021 @entity1 treated during the period 1977-1986 at two Swedish gynecologic oncology centers were analyzed regarding treatment set-up, histopathologic outcome in the operative specimens, recurrence rates, survival rates and radiation side effects. Complete @entity5 eradication in the operative specimen was achieved in 80% after radium therapy and in 60% after irradiation by the high dose-rate technique. The overall recurrence rate was 15.7% in the radium packing series and 11.5% after @entity1953 afterloading treatment. The risk of pelvic recurrences increased by 2.1-2.6 if hysterectomy was replaced by dilatation and curettage. The two radiation techniques seemed to be comparable with regard to the risk of both pelvic recurrences and distant metastases. The 5-year crude survival rates were 85% in the afterloading series and 82% in the radium series. The corrected survival rates were similar (90%) for the two techniques. Age, @entity5 grade and uterine size were significant prognostic factors with regard to the probability of death due to @entity5 . Early radiation reactions had quite similar rates in the two series, whereas late radiation reactions were more frequent in the high dose-rate afterloading group in the 10-12 Gy dose fraction range, but not in the 5-8 Gy range. The radium packing method seemed to give a higher frequency of @entity5 -free operative specimens in this study, but with regard to recurrence rates and survival probabilities the techniques were comparable. Since the different proportion of surgery in the two series and the histopathologic evaluation might have influenced the rate of local @entity5 eradication in the operative specimens and the risk of pelvic recurrences the results must be assessed with great caution and only a crude comparison of the two treatment techniques could be made.

title: Prognosis of XXXX stage I in two Swedish regions. A study with special regard to the effects of intracavitary irradiation with high dose-rate afterloading technique or with low dose-rate radium.

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinoma']


abstract: It is not surprising that a compound with such unique properties as @entity3655 / @entity17114 +, should have a large variety of biochemical and neurological effects and to find itself implicated in many pathological conditions. Its undissociated ( @entity3655 ) or dissociated ( @entity17114 ) forms, having different physicochemical properties, enter neurons and other cells through differing pathways. These two forms then change internal pH in opposite directions, and initiate a variety of regulatory processes that attempt to overcome these pH changes. In addition, @entity3265 has a central role in normal intermediary metabolism, and when present in excess, it can disturb reversible reactions in which it participates. The challenge in interpreting these various observations lies in the difficulty in assigning to them a role in the generation of symptoms seen in experimental and clinical @entity3263 . In this review we have attempted to summarize information available on the effects of @entity3104 ions on synaptic transmission, a central process in nervous system function. Evidence has been presented to show that @entity3104 ions, in pathologically relevant concentrations, interfere with glutamatergic excitatory transmission, not by decreasing the release of @entity2227 , but by preventing its action on post-synaptic @entity140 receptors. Furthermore, @entity17114 + depolarizes neurons to a variable degree, without consistently changing membrane resistance, probably by reducing [K+]i. A decrease in EK+ may also be responsible for decreasing the effectiveness of the outward @entity2865 pump, thus explaining the well known inhibitory effect of @entity17114 + on the hyperpolarizing IPSP. There is a consensus of opinion that chronic @entity3263 increases 5HT turnover and this may be responsible for altered sleep patterns seen in @entity99 . There does not seem to be a consistent effect on catecholaminergic transmission in @entity3263 . However, chronic @entity3263 causes pathological changes in perineuronal astrocytes, which may lead to a reduced uptake of released @entity2227 and a decreased detoxification of @entity3265 by the brain. Chronic moderate increase in extracellular @entity2227 results in a down-regulation of @entity143 receptors, while the decreased detoxification of @entity3265 makes the central nervous system more vulnerable to a sudden @entity3263 , due, for instance, to an increased dietary intake of proteins or to @entity360 in @entity1 with @entity409 . Clearly, data summarized in this review represent only the beginning in the elucidation of the mechanism of @entity3265 @entity2359 . It should help, we hope, to direct future investigations towards some of the questions that need to be answered.

title: Effect of XXXX ions on synaptic transmission in the @entity1 central nervous system.

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

entities_list: @entity3104 :: ('MESH:D000644', 'Chemical') :: ['ammonium']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']

entities_list: @entity3263 :: ('MESH:D022124', 'Disease') :: ['hyperammonemias', 'hyperammonemia']

answer: @entity3104 :: (MESH:D000644,Chemical) :: ['ammonium']


abstract: @entity299 is the leading cause of mortality in western countries. Apart from congenital and anatomical alterations, @entity63 is the most common agent causing @entity296 . During @entity63 , a sudden decrease in @entity26 concentration alters cardiomyocyte function and compromises cell survival. The @entity460 handling machinery, which regulates the main functional features of a cardiomyocyte, is heavily compromised during acute @entity519 events. Alterations in @entity460 dynamics have been linked to both short- and long-term consequences of @entity63 , ranging from @entity943 to @entity712 . In this perspective, we aimed at investigating the @entity460 dynamics in functional cardiomyocytes during the early phase of a @entity519 event. For this purpose, we developed a microfluidic system specifically designed for controlling fast @entity26 concentration dynamics through a gas micro-exchanger allowing in line analysis of intracellular @entity460 concentration by confocal microscopy. Experimental results show that exposure of @entity20048 loaded neonatal @entity35 cardiomyocytes to @entity519 conditions induced changes in intracellular @entity141 transients. Such behavior was reversible and was detected for @entity519 levels below 5% of @entity26 partial pressure. The observed changes in @entity141 dynamics were mimicked using specific L-type @entity141 channel antagonists, suggesting that alterations in @entity460 channel function occur at low @entity26 levels. Reversible alteration in ion channel function, that takes place in response to changes in cellular @entity26 , might represent an adaptive mechanism of cardiopreservation during @entity63 .

title: Reversible alteration of XXXX dynamics in cardiomyocytes during acute @entity519 transient in a microfluidic platform.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Heart disease']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: OBJECTIVE: To explore the role of metabolism of fatty substance and osteoclast activity during the process of @entity134 -induced @entity39 of @entity2738 through @entity19 model inducing and model index measurement. METHODS: Forty SD male @entity19 were divided into 2 groups randomly, the control group and the experiment group. After the gluteal injection of colibacillus endotoxin,the experiment group was given gluteal injection of @entity12356 35.5 mg/kg per week, and 2 ml of normal saline to the control group. The @entity19 were killed 12 weeks later and tested the content of Trap-5b, TC and TG of the blood serum. Vitodynamics, bone density were measured and sections of HE staining, @entity141 and @entity9334 staining was made then statistic analysis was performanced. RESULTS: The content of TC, TG and Trap-5b increased apparently (P < 0.01). Large amount of osteoclasts were found in local medullary cavity. There was severe @entity604 and decrease of vitodynamics in subchondral bone (P < 0.01) in experiment group. CONCLUSION: @entity209 of fatty substance is the key pathogenesis of @entity134 -induced @entity2530 of @entity2738 . Decrease of vitodynamics in subchondral bone due to @entity2915 and increase of osteoclast lead to collapse of @entity2738 directly.

title: [Research on the role of metabolism of fatty substance and osteoclast activity during the development of @entity134 -induced XXXX of @entity2738 ].

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic disorder']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity']

entities_list: @entity12356 :: ('MESH:C009935', 'Chemical') :: ['prednisolone acetate']

entities_list: @entity2738 :: ('MESH:D005271', 'Disease') :: ['femoral head']

entities_list: @entity2530 :: ('MESH:D010020', 'Disease') :: ['avascular necrosis']

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrosis']


abstract: Selection of therapy for @entity189 of the proximal esophagus is controversial. We reviewed our experience with 41 @entity1 with @entity189 within 24 centimeters of the incisor teeth to address this issue. Thirty-seven @entity1 had @entity957 , three had @entity420 and one @entity1 had a @entity3975 . Seventeen @entity1 underwent surgical therapy, which consisted of a resection in 15, colonic bypass in one @entity1 and extracorporeal bypass in one. Ten @entity1 underwent postoperative radiation therapy. Radiation therapy was the primary treatment in 23 @entity1 and chemotherapy alone in one @entity1 . The three month mortality rate was similar for @entity1 with @entity5 resection and for those receiving radiation therapy as the primary treatment. Median survival time for @entity1 undergoing resection and adjuvant radiation therapy was 12 months and seven months for those receiving only irradiation. Statistical analyses were not performed because @entity1 with radiation only had more @entity1442 , invalidating comparison. In terms of palliation, ten of the @entity1 who had radiation therapy could eat solid food, seven could only swallow liquids and six had persistent, @entity3885 . All 12 of the survivors who had a resection were able to eat solid food. Although the one month mortality rate is higher for those treated surgically than with radiation therapy, the three month mortality rates are similar. Surgical treatment provides better palliation and a reasonable survival time and is preferred for @entity1 with resectable disease who are physiologically fit enough to undergo operation. A benefit of postoperative adjuvant radiation therapy is undefined but probably present.

title: Treatment of XXXX of the proximal esophagus.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3975 :: ('MESH:D018277', 'Disease') :: ['mucoepidermoid carcinoma']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the esophagus', 'carcinoma']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['complete obstruction']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinoma']