abstract: CONCLUSIONS: The limitation in olfactory function in @entity1 with @entity2023 ( @entity2023 ) can be ascribed to an increase in eosinophilic and mast cell activity in the olfactory cleft. Therefore, the decrease in olfactory functions seems to be predominantly caused by the @entity32 of the epithelium and not by the obstruction of the nose caused by the @entity32 . OBJECTIVE: @entity4838 is frequently seen in @entity1 with @entity2023 ; however, little is known about the underlying pathophysiological mechanisms. Therefore, the aim of the present study was to examine the olfactory function in @entity1 with seasonal or perennial @entity2023 , and to correlate the results with data obtained by analysis of nasal secretion and obstruction. METHODS: Olfactory function was tested using the Sniffin  Sticks test in @entity1 with seasonal or perennial @entity2023 and in a control group. Nasal secretion analysis included eosinophilic cationic protein (ECP) and tryptase testing. Nasal obstruction was evaluated by rhinomanometry. RESULTS: @entity1 with @entity2023 (seasonal @entity9590 ) showed @entity73 in comparison with the control group. Nasal secretion analysis showed increased values of ECP and tryptase in the seasonal group in comparison with controls. Rhinomanometry showed no differences in nasal flow between the three groups.

title: XXXX in seasonal and @entity9590 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'seasonal allergic rhinitis']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired olfactory functions']

entities_list: @entity4838 :: ('MESH:D000857', 'Disease') :: ['Olfactory dysfunction']

entities_list: @entity9590 :: ('MESH:D012221', 'Disease') :: ['and perennial']

answer: @entity4838 :: (MESH:D000857,Disease) :: ['Olfactory dysfunction']


abstract: A @entity17589 complicating @entity4943 ( @entity4943 ) has been recognised and designated @entity20281 ( @entity20281 ). @entity4943 is characterised by profound character change and altered social conduct, and @entity51 , reflecting focal degeneration of the frontal and temporal neocortex. The @entity17589 comprises @entity10296 and @entity4218 . The major histological change is typically of microvacuolation of the cerebral cortex, with @entity194 of the bulbar neurones and anterior horn cells of the spinal cord. Ubiquitinated inclusion bodies occur in large pyramidal cortical neurones and in surviving cranial nerve nuclei and anterior horn cells. Evidence is emerging that some @entity1 with classical @entity746 ( @entity746 ), who are thought not to be demented, develop @entity73 in the realm of frontal executive functions. Moreover, frontal @entity75 have been demonstrated by neuroimaging. The findings point to a link between @entity4943 / @entity20281 and cMND/ @entity746 and suggest that a proportion of @entity1 with cMND/ @entity746 go on to develop @entity4943 . @entity1 with cMND/ @entity746 may not be equally vulnerable. The hypothesis is that @entity1 who present with @entity10296 and @entity3949 , rather than corticospinal and corticobulbar features, may be most susceptible to the development of @entity4943 .

title: @entity73 in motor neurone disease/ @entity746 ( XXXX / @entity746 ).

entities_list: @entity10296 :: ('MESH:D010244', 'Disease') :: ['bulbar palsy']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['lobe abnormalities']

entities_list: @entity4218 :: ('MESH:D017880', 'Disease') :: ['limb amyotrophy']

entities_list: @entity3949 :: ('MESH:D003929', 'Disease') :: ['amyotrophy']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['executive deficits']

entities_list: @entity20281 :: ('MESH:C566288', 'Disease') :: ['MND', 'FTD/motor neurone disease']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'MND/amyotrophic lateral sclerosis']

entities_list: @entity4943 :: ('MESH:D057180', 'Disease') :: ['FTD', 'frontotemporal dementia']

entities_list: @entity17589 :: ('MESH:D009134', 'Disease') :: ['motor neuronopathy']

answer: @entity20281 :: (MESH:C566288,Disease) :: ['MND']


abstract: PURPOSE: It is a challenge to rescue ophthalmology examinations performed in @entity1 in the sedation room after initial @entity22292 failure. Intranasal @entity6948 can be used in rescue sedation in @entity1 undergoing computed tomography. The present study aimed to assess the efficacy and tolerability of intranasal @entity6948 use in @entity1 undergoing ophthalmic examination after @entity22292 failure. METHODS: Sixty uncooperative pediatric @entity1 with @entity231 (aged 5-36 months; weight, 7-15 kg) presented for follow-up ophthalmic examination. @entity1 who experienced @entity22292 failure were randomized to 1 of 2 groups to receive intranasal @entity6948 1 or 2  g/kg for rescue sedation. Each group contained 30 @entity1 . The primary outcome was the rate of a successful ophthalmic examination. Secondary outcomes included sedation onset time, recovery time, duration of examination, discharge time, and adverse events, including percentage of heart rate reduction, @entity1576 , @entity391 , and postsedative @entity2146 . FINDINGS: A successful ophthalmic examination was achieved in 93.3% (28/30) of @entity1 in the 2- g/kg dose group and in 66.7% (20/30) of @entity1 in the 1- g/kg dose group (P = 0.021). The onset time, recovery time, and discharge time did not significantly differ between the 2 groups. None of the @entity1 required clinical intervention due to heart rate reduction, and none of the @entity1 in either group experienced @entity391 , @entity1576 , or @entity2146 after the administration of @entity6948 . IMPLICATIONS: In @entity1 undergoing ophthalmic examination, intranasal @entity6948 can be administered in the sedation room for rescue sedation after @entity22292 failure, with the 2- g/kg dose being more efficacious than the 1- g/kg dose, as measured by success rate. ClinicalTrials.gov identifier: NCT02077712.

title: Rescue Sedation With Intranasal @entity6948 for Pediatric Ophthalmic Examination After XXXX Failure: A Randomized, Controlled Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory depression']

entities_list: @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine']

entities_list: @entity22292 :: ('MESH:D002697', 'Chemical') :: ['chloral hydrate']

answer: @entity22292 :: (MESH:D002697,Chemical) :: ['Chloral Hydrate']


abstract: OBJECTIVES: To explore whether @entity1 experience greater delays in the @entity1494 and @entity703 when first presenting to a general practitioner with symptoms caused by those @entity5 and potential reasons for such gender inequalities. DESIGN: Prospective national audit survey of @entity5 diagnosis. SETTING: English primary care (2009-2010). @entity1 : 920 @entity1 with bladder and 398 @entity1 with @entity703 (252 (27%) and 165 (42%), respectively, were @entity1 ). PRIMARY AND SECONDARY OUTCOME MEASURES: Proportion of @entity1 with three or more pre-referral consultations; number of days from first presentation to referral; proportion of @entity1 who presented with haematuria and proportion of @entity1 investigated in primary care. RESULTS: @entity1 required three or more prereferral consultations more often than @entity1 (27% (95% CI 21% to 33%) vs 11% (9% to 14%) for bladder (p<0.001); and 30% (22% to 39%) vs 18% (13% to 25%) for @entity703 (p=0.025)) and had a greater number of days from presentation to referral. In multivariable analysis (adjusting for age, haematuria status and use of primary care-led investigations), being a @entity1 was independently associated with higher odds of three or more pre-referral consultations (OR=3.29 (2.06 to 5.25, p<0.001) for @entity150 ; and OR=1.90 (1.06 to 3.42, p=0.031) for @entity703 ). Although presentation with haematuria was associated with more timely @entity1494 cancer, gender inequalities did not vary by haematuria status for either @entity5 (p=0.18 for bladder and p=0.27 for renal). Each year in the UK, approximately 700 @entity1 with either @entity150 experience a delayed diagnosis because of their gender, of whom more than a quarter (197, or 28%) present with haematuria. CONCLUSIONS: There are notable gender inequalities in the timeliness of diagnosis of @entity5 . There is a need to both reinforce existing guidelines on haematuria investigation and develop new diagnostic decision aids and tests for @entity1 who present without haematuria.

title: Gender inequalities in the promptness of @entity1494 and XXXX after symptomatic presentation: evidence from secondary analysis of an English primary care audit survey.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients', 'Women', 'PARTICIPANTS', 'men']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['diagnosis of bladder']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'urological cancers', 'cancer']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder or renal cancer', 'bladder cancer']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal cancer']

answer: @entity703 :: (MESH:D007680,Disease) :: ['renal cancer']


abstract: The purpose of this study was to define the role of splenectomy in @entity1 (pts) with @entity1073 ( @entity1073 ) with regard to improving @entity1503 and symptoms of @entity381 . 26 pts with @entity1073 underwent splenectomy between January 1987 and October 1999 and were followed prospectively for hematologic response and operative morbidity and mortality. A positive response was defined at 1 month of follow-up as: a hemoglobin of > or = 1.0 g/dl in a pt with a preoperative value < 11.0 g/dl; or a platelet count of > or = 100 x 10(9)/L in a pt with a preoperative value < 100 x 10(9)/L. A positive hematologic response was achieved in 69.2% of pts with preoperative @entity417 , 90% with @entity882 , and 50% with both @entity417 and @entity882 . The peri- and post-operative morbidity were 3.8 and 19.2%, respectively, the operative mortality was 0%. The median duration of hospitalization was six days. Four (15.4%) pts have not required chemotherapy after splenectomy. Three of these four were previously untreated and they have maintained stable disease for eight years after splenectomy without chemotherapy. Eight additional pts did not require chemotherapy for > 13 months after splenectomy. These results suggest that splenectomy may provide durable remission in selected pts with @entity1503 or symptoms related to @entity381 in pts with @entity1073 . There is a subset of pts that have prolonged disease stabilization without the requirement for immediate chemotherapy after splenectomy.

title: Efficacy of splenectomy for XXXX with mantle cell non-Hodgkin's lymphoma.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['cytopenias', 'refractory cytopenias']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity1073 :: ('MESH:D020522', 'Disease') :: ['mantle cell lymphoma', 'MCL']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Antihypertensive medications, including b-blockers, are widely used in @entity1 with @entity740 . Unlike most b-blockers, @entity2165 is excreted primarily by the kidney, and its clearance by peritoneal dialysis is poor. These pharmacokinetic factors may predispose @entity1 to gradual accumulation of the drug over time. OBJECTIVES: To review the management of a diagnostic dilemma, the role of glucagon therapy, and the clinical implications of @entity2165 clearance. CASE REPORT: A young @entity1 with @entity454 requiring peritoneal dialysis presented with sudden onset of @entity490 and @entity1344 with @entity551 and relative @entity1168 . The @entity1 reported that she took her regular four antihypertensive agents, including @entity2165 , with no excess ingestion or recent dose changes. After resuscitation and consideration of a broad differential diagnosis, the most likely cause of the @entity1 's illness was determined to be unintentional @entity2165 @entity137 , with secondary @entity5327 due to a low-flow state that caused her @entity490 . Glucagon therapy led to rapid correction of the @entity1 's @entity1344 and @entity158 . CONCLUSION: The unique pharmacokinetics of long-term medications must be considered in @entity1 with  impaired clearance, such as this @entity1 with @entity454 treated by peritoneal dialysis. Medications may gradually accumulate to supratherapeutic levels, which over time may lead to symptoms of significant @entity137 .

title: Hemodynamically unstable: accidental XXXX @entity137 ?

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['hemodynamic instability']

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity5327 :: ('MESH:D065666', 'Disease') :: ['mesenteric ischemia']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity2165 :: (MESH:D001262,Chemical) :: ['atenolol']


abstract: A 60-year-old female was admitted with a chief complaint of left hemothorax. Chest X-ray films revealed an abnormal shadow when the @entity1143 disappeared. On the physical examination, multiple @entity8721 were found at the nasal mucosa, tongue and stomach. The family history showed that her @entity5461 experienced frequent episodes of @entity1415 . The @entity1 was diagnosed to have @entity1884 . CT scanning and pulmonary angiography showed an arteriovenous fistula of the left lower lobe ( @entity8785 ) and cerebral angiography did a small arteriovenous fistula in the cerebellum. Pulmonary partial resection was performed to prevent re- @entity548 . @entity2702 was 2.5 x 1.5 cm in size. It located in the left lower lobe exposing through the surface of the lung over the diaphragm. The postoperative course was uneventful and she was discharged on the 18th postoperative day without any complications.

title: [A case of @entity1884 associated with XXXX ].

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion']

entities_list: @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectases']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1415 :: ('MESH:D004844', 'Disease') :: ['epistaxis']

entities_list: @entity1884 :: ('MESH:D013683', 'Disease') :: ['Rendu-Osler-Weber disease']

entities_list: @entity2702 :: ('MESH:C562404', 'Disease') :: ['Pulmonary arteriovenous fistula']

answer: @entity2702 :: (MESH:C562404,Disease) :: ['pulmonary arteriovenous fistula']


abstract: The technique of perifusing @entity35 thyroid fragments was used to investigate the presence of thyroid-stimulating antibodies (TSAb) in the sera of 48 @entity1 . Response to IgG was measured by determining the mean rate of release of T4 (R) during a 30-min perifusion and the secretion peak (Imax) by means of samples taken every 5 min. Values found to be above the mean + 2 SD of the control values of R or Imax were considered to be positive. TSAb were found in all the 17 @entity1 with untreated @entity2743 ( @entity2743 ) and in the 2 treated with antithyroid drugs, but not in the 3 who had undergone surgery or 131I treatment or in the 2 on corticosteroid treatment. TSAb were also found in 2 out of 3 @entity1 with untreated nodular toxic goiter (UNTG) and in 6 out of 8 with @entity5651 ( @entity5651 ) but at lower levels. In the untreated @entity2743 group, R and Imax correlated significantly with the corresponding IgG concentrations (from 90 to 800 micrograms/ml), suggesting TSAb activity which can be compared from one @entity1 to another. TSAb activity did not correlate with thyroid function tests in any group. In all the groups it induced an early secretion peak followed by a decreasing response throughout the stimulation period, as was previously found with 65 mIU/ml TSH. The specificity of this technique was verified by five different control methods: the perifusion technique was checked by using KRBG buffer alone; sera were studied from a group of healthy controls.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Detection of thyroid-stimulating antibodies in thyroid diseases, employing XXXX thyroid fragment perifusion.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5651 :: ('MESH:D006042', 'Disease') :: ['DNG', 'diffuse nontoxic goiter']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease", 'GD']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: INTRODUCTION: Hemodialysis is the preferred method of treatment for Nepalese @entity1 with @entity454 . Despite the technological advances and better understanding of physiology associated with hemodialysis, a number of complications are known to be associated with hemodialysis. This study was undertaken to study the frequency of acute @entity532 in @entity1 undergoing hemodialysis. METHODS: A cross-sectional study was conducted at Nephrology unit of a tertiary care hospital from 15 June, 2007 to 15 December, 2007. A total of 28 @entity1 were included in the study. @entity1 with @entity810 and @entity810 were excluded from the study. RESULTS: Total sessions of hemodialysis during the period were 1455. @entity551 episode were 66 (4.5%) and was the commonest complication and followed by @entity101 episodes were 58 (3.8%). @entity5 encountered were transfusion reactions were 23 episodes (1.5%), rigors not related to transfusions were 13 episodes (0.8%), @entity390 / @entity391 were 20 episodes (1.4%), muscle cramps were 12 episodes (0.8%), @entity4053 were 6 episodes 5(0.4%). CONCLUSIONS: The frequency of @entity532 is low and many of them are not life threatening.

title: Acute @entity532 in XXXX on maintenance hemodialysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Other problems']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['intradialytic complications']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute on chronic renal failure', 'acute renal failure']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['Hypotensive']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end stage renal disease']

answer: @entity454 :: (MESH:D007676,Disease) :: ['end stage renal disease']


abstract: @entity1 with metastatic @entity0 face a wide range of medical, practical, and emotional challenges that impact their quality of life. Research to date, however, has not focused on the quality-of-life concerns of metastatic @entity0 @entity1 with significant distress. The present study examined a range of concerns among distressed metastatic @entity0 @entity1 , including @entity147 , social functioning, and existential issues. Forty-four distressed @entity1 with metastatic @entity0 wrote their deepest thoughts and feelings regarding their illness. These essays were thematically analyzed for effects of the illness on quality of life. Three themes were identified in @entity1 ' essays. First, metastatic @entity0 and its treatment may result in a number of quality-of-life concerns, including physical symptom burden, @entity147 , @entity4238 disturbance, and disrupted daily activities. Second, social constraints on disclosure of @entity5 -related concerns may exacerbate @entity1 ' distress. Third, many @entity1 experience a heightened awareness of life's brevity and search for meaning in their @entity5 experience. Results highlight a range of quality-of-life concerns following a metastatic @entity0 diagnosis and suggest that addressing social constraints on @entity5 and the search for meaning may improve @entity1 ' psychological adjustment.

title: Living with metastatic XXXX : a qualitative analysis of physical, psychological, and social sequelae.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cancer-related disclosure']

entities_list: @entity147 :: ('MESH:D005316', 'Disease') :: ['emotional distress', 'physical and emotional distress']

entities_list: @entity4238 :: ('MESH:D057215', 'Disease') :: ['body image']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: From January, 1990 to December, 1995, 113 cases of @entity1204 were registered. Of them, 24 @entity1 (20%) had associated medical disorders. A total of 37 medical disorders were found in these 24 @entity1 . The distribution was as follows: @entity6 in 15 @entity1 , @entity101 in 13 @entity1 , @entity453 in two, @entity565 in one, RBBB in one and @entity1375 in five @entity1 . Age of the @entity1 ranged from 48-76 years (Median 62 years). Fifteen @entity1 underwent surgery and rest nine were inoperable due to medical illnesses. Eleven @entity1 received radiotherapy and four received chemotherapy. Of the two failures, one developed @entity3 to lung and another to bone. No local recurrence was observed. Median survival was 20 months. Late radiation morbidity was noticed in four @entity1 (36%), all of them were @entity6 . CONCLUSION: @entity1375 which was unexpectedly found in five @entity1 may also be a risk factor associated with @entity1204 . This finding has never been reported in the literature and it needs to be curiously studied in future series. The risk of late radiation complications is higher in @entity6 @entity1 . Overall prognosis of @entity1204 associated with medical illnesses is not very good.

title: Medical disorders associated with XXXX .

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['Hypothyroidism', 'hypothyroidism']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes mellitus']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinoma']


abstract: PURPOSE: To report the long-term visual outcome of eyes that underwent primary trabeculectomy for @entity726 and to evaluate factors that affect visual prognosis. METHODS: Thirty-five eyes of 22 consecutive @entity1 presenting between 1980 and 1995 were included. Visual acuity, visual fields and refractive status were assessed and @entity1 records reviewed. RESULTS: Nineteen of 22 @entity1 (86.3%) achieved 6/12 or better, (21 of 35 eyes; 60%). Reasons for @entity227 included @entity4457 (5 eyes), field loss (4 eyes), corneal opacification (2 eyes), and uncontrolled IOP (1 eye). Primary @entity726 had a better outcome than @entity726 . Vision was frequently unequal despite controlled pressure, clear media and full fields in both eyes. This was associated with myopic @entity9340 and apparent @entity4457 . Ten @entity1 responded to patching. Eyes with field defects were unresponsive to patching. CONCLUSIONS: Field defects, @entity267 , marked @entity9340 and severe @entity940 result in @entity227 . @entity4457 is frequently present and responds well to patching. Visual outcome is dependent on early and sustained control of intraocular pressure and aggressive treatment of @entity4457 .

title: Long-term visual results following primary trabeculectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['poor vision', 'decreased vision']

entities_list: @entity267 :: ('MESH:D065306', 'Disease') :: ['corneal scarring']

entities_list: @entity9340 :: ('MESH:D015858', 'Disease') :: ['anisometropia']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['infantile glaucoma', 'glaucoma', 'secondary glaucoma']

entities_list: @entity4457 :: ('MESH:D000550', 'Disease') :: ['amblyopia', 'Anisometropic amblyopia']

answer: @entity726 :: (MESH:D005901,Disease) :: ['infantile glaucoma']


abstract: OBJECTIVES: Conventional T2 weighted MRI studies have highlighted the fact that the presence of clinically silent @entity75 increases the risk of developing clinically definite @entity15 after an isolated syndrome of the optic nerve, brain stem, or spinal cord. The objectives of the present study are: (1) to show whether or not these @entity1 also have asymptomatic abnormalities of the spinal cord, and (2) to recruit a new cohort of such @entity1 using high resolution MRI of both brain and spinal cord. METHODS: The brain was imaged in the axial plane with 3 mm thick contiguous slices using a proton density and T2 weighted fast spin echo (FSE) sequence; a T1 weighted sequence after the injection of @entity7241 ; and a fast fluid attenuated inversion recovery (fFLAIR) sequence. The spinal cord was imaged in the sagittal plane with 3 mm thick slices using a T2 weighted FSE and a T1 weighted @entity2287 enhanced sequence. RESULTS: Thirty three @entity1 , mean age 31 (16-46) were recruited. There were 14 @entity1 and 19 @entity1 . Brain MRI was abnormal in 22 (67%); no @entity1 was seen with abnormalities on only one or other sequence. Six @entity1 (18%) displayed one or more @entity2287 enhancing lesions on brain MRI. In the spinal cord, nine (27%) @entity1 displayed one or more clinically silent lesions on FSE. Two @entity1 showed one and two @entity2287 enhancing lesions in the spinal cord respectively. CONCLUSION: This high incidence of @entity602 emphasises that asymptomatic @entity17 may also involve clinically eloquent pathways. Follow up studies are required to determine their prognostic importance.

title: Asymptomatic XXXX in clinically isolated optic nerve, brain stem, and spinal cord syndromes suggestive of @entity17 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelinating lesions']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord lesions']

entities_list: @entity7241 :: ('MESH:D019786', 'Chemical') :: ['gadolinium-DTPA']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

answer: @entity602 :: (MESH:D013118,Disease) :: ['spinal cord lesions']


abstract: Whether the @entity1184 found in the hearts of athletes is physiologic or a risk factor for the progression of @entity1184 remains controversial. The diastolic and systolic functions of athletes with left ventricular (LV) @entity1184 usually are normal when measured by conventional methods. More precise assessment of global and regional myocardial function may be possible using a newly developed two-dimensional (2D) strain echocardiographic method. This study evaluated the effects that different types of sports have on the hearts of @entity1 and adolescents and compared the results of 2D strain and strain-rate echocardiographic techniques with conventional methods. Athletes from clubs for five different sports (basketball, swimming, football, wrestling, and tennis) who had practiced regularly at least 3  h per week during at least the previous 2  years were included in the study. The control group consisted of sedentary @entity1 and adolescents with no known @entity299 (n  =  25). The athletes were grouped according to the type of exercise: dynamic (football, tennis), static (wrestling), or static and dynamic (basketball, swimming). Shortening fraction and ejection fraction values were within normal limits for the athletes in all the sports disciplines. Across all 140 athletes, LV geometry was normal in 58 athletes (41.4  %), whereas 22 athletes (15.7  %) had concentric remodeling, 20 (14.3  %) had @entity1184 , and 40 (28.6  %) had @entity1184 . Global LV longitudinal strain values obtained from the average of apical four-, two-, and three-chamber global strain values were significantly lower for the basketball players than for all the other groups (p  <  0.001).

title: Effects that different types of sports have on the hearts of XXXX and adolescents and the value of two-dimensional strain-strain-rate echocardiography.

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['eccentric hypertrophy', 'concentric hypertrophy', 'hypertrophy', 'pathologic hypertrophy']

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac or systemic diseases']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Emergency esophagogastroduodenoscopy for active @entity360 was performed in 160 @entity1 . Endoscopic electrocautery for control of @entity548 was considered in the last ninety @entity1 and performed in seventy-one @entity1 . All lesions except esophageal varices were candidates for electrohemostasis. The indications for endoscopic electrocautery were active @entity548 and precise identification of the @entity548 point. The preendoscopic @entity190 ranged from 1,500 to 6,000 ml. All seventy-one @entity1 had initial hemostasis and sixty-five (92 per cent) had permanent hemostasis after one treatment. Six @entity1 rebled, and four of these had permanent hemostasis after a second endoscopic electrocauterization. Only two of seventy-one @entity1 had emergency operations for @entity548 . There were no complications. Endoscopic electrohemostasis is still an experimental technic which requires further laboratory study and testing before broad general clinical application. This clinical trial suggests that endoscopic electrocautery is an attractive method of controlling active @entity360 because it can be safe, effective, and rapid, and is available in most medical communities.

title: Endoscopic electrohemostasis of active XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['upper gastrointestinal bleeding']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'hemorrhage']

answer: @entity360 :: (MESH:D006471,Disease) :: ['upper gastrointestinal bleeding']


abstract: The role of @entity28 and overweight as independent risk factors for @entity65 is still debated. The aim of this study was to evaluate the impact of overweight on @entity65 according to the presence or absence of associated risk factors. This study included 139,562 @entity1 and 104,236 @entity1 , aged 18 to 95 years, who had a standard health checkup at the IPC Center between 1972 and 1988. The follow-up period for mortality ended in December 1997. In both genders, the prevalence of @entity101 , @entity6 , and @entity1007 increased with body mass index (P<0.001). When compared with subjects with a body mass index <25 kg/m2 without associated risk factors, overweight subjects without associated risk factors did not have an increased risk of @entity65 . Risk of @entity65 increased significantly when overweight was associated with @entity101 alone [hazard ratio: 2.05 (1.71 to 2.46) in @entity1 ; 2.15 (1.48 to 3.11) in @entity1 ]. In both genders, the association of overweight with @entity6 alone or @entity1007 alone did not increase the risk. By contrast, in the presence of @entity101 , @entity65 dramatically increased in overweight subjects with @entity1007 [hazard ratio: 2.65 (2.20 to 3.19) in @entity1 , 2.57 (1.80 to 3.68) in @entity1 ] or @entity6 [hazard ratio: 3.01 (2.29 to 3.95) in @entity1 ; 4.50 (2.67 to 7.58) in @entity1 ]. The data suggest that the presence of high blood pressure in overweight subjects is the key factor leading to a significant increase in @entity65 . Because overweight significantly increases the prevalence of associated risk factors, especially @entity101 , it should be considered as a major cardiovascular risk determinant.

title: XXXX in overweight subjects: the key role of associated risk factors.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'cardiovascular death', 'cardiovascular disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['Cardiovascular mortality']


abstract: <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To our knowledge, no studies have aimed at improving the PA level in south Asian immigrant men residing in @entity1 tern countries, and few studies have considered the relevance of SCT constructs t @entity12497 he PA behaviour of this group in the long term. The observed low physical activity (PA) level among south Asian immigrants in Western countries may partly explain the high prevalence of cardiovascular d @entity65 2 @entity65 betes @entity2175 ro @entity2175 We have shown previously in a randomised controlled trial, the Physical Activity and Minority Health study (PAMH) that a social cognitive based intervention can beneficially influence PA level and subsequently reduce waist circumference and insulin resistance in the short-term. In an extended follow-up of the PAMH study: we aimed 1) to determine if the intervention produced long-term positive effects on PA level six months after intervention (follow-up 2 (FU2)), and 2) to identify the social cognitive mediators of any intervention effects. METHODS: Physically inactive Pakistani immigrant men (n = 150) wh @entity1 ere free of CVD and T2D were @entity65 ndoml @entity2175 ssigned to a five months PA intervention or a control group. Six months after the intervention ended, we telephoned all those who attended FU1 and invited them for a second follow-up test (FU2) (n = 133). PA was measured using ActiGraph accelerometers. Statistical differences between groups were determined by use of ANCOVA. RESULTS: Significant differences (baseline to FU2) between the groups were found for all PA variables (e.g., total PA level, sedentary time, PA intensity). Support from family and outcome expectancies increased more in the intervention group compared with the control group. Self-efficacy did not differ significantly between groups. CONCLUSIONS: Our results show that a multi component PA programme can increase PA over the short and long term in a group of immigrant Pakistani men. However, we @entity1 uld not identify the factors that mediated these changes in PA. PROTOCOL ID: 07112001326, NCT ID: NCT00539903.

title: Physical activity levels six months after a randomised controlled physical activity intervention for Pakistani immigrant XXXX living in Norway.

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular diseases']

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['type 2 diabetes', 'T2D']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: We analyzed submission data from a wildlife care group during amphibian disease surveillance in Queensland, Australia. Between January 1999 and December 2004, 877 white-lipped tree frogs Litoria infrafrenata were classified according to origin, season and presenting category. At least 69% originated from urban Cairns, significantly more than from rural and remote areas. Total submissions increased during the early and late dry seasons compared with the early wet season. Frogs most commonly presented each year with injury, followed by 'other', @entity5472 and irreversible emaciation of unknown aetiology. This is the first report of @entity383 @entity281 in this species. A high prevalence (28%) of visible @entity383 @entity281 was found in emaciated frogs, but this was not statistically different from that in non-emaciated diseased frogs (25%). However, 14 emaciated specimens that were necropsied all had heavy @entity383 @entity281 , and the odds of visible @entity5472 were statistically greater in emaciated frogs compared with injured, non-diseased frogs. We provide a detailed case definition for a new @entity66 manifesting as irreversible emaciation, for which @entity383 may be the primary aetiological agent. The lack of significant spatial or temporal patterns in case presentation suggests that this is not a currently emerging disease. We show that community wildlife groups can play a valuable role in monitoring disease trends, particularly in urban areas, but identify a number of limitations associated with passive syndromic surveillance. We conclude that it is critical that professionals be involved in establishing @entity751 , diagnostic pathology, @entity66 , and data analysis and interpretation in all wildlife disease investigations.

title: Using community surveillance data to differentiate between emerging and XXXX .

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['endemic disease', 'complementary active disease surveillance']

entities_list: @entity383 :: ('99802', 'Species') :: ['Spirometra erinacei', 'S. erinacei']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['syndromic case definitions']

entities_list: @entity5472 :: ('MESH:D013031', 'Disease') :: ['sparganosis']

answer: @entity66 :: (MESH:D004194,Disease) :: ['endemic amphibian diseases']


abstract: The current paradigm of major histocompatibility complex (MHC) and disease association suggests that efficient binding of autoantigens by disease-associated MHC molecules leads to a T cell-mediated immune response and resultant autoimmune sequelae. The data presented below offer a different model for this association of MHC with autoimmune @entity6 . We used several @entity19 lines expressing different levels of @entity19665 and I-Ak on the nonobese @entity6 (NOD) background to evaluate the role of MHC class II in the previously described NOD T cell autoproliferation. The ratio of @entity19665 to I-Ak expression correlated with the peripheral T cell autoproliferative phenotype in the @entity19 studied. T cells from the NOD, [NOD x NOD. I-Anull]F1, and NOD I-Ak @entity19 demonstrated autoproliferative responses (after priming with self-peptides), whereas the NOD.H2(h4) (containing I-Ak) congenic and [NOD x NOD. H2(h4) congenic]F1 @entity19 did not. Analysis of @entity1961 (+) NOD I-Ak transgenic primed lymph node cells showed that autoreactive @entity1961 (+) T cells in the NOD I-Ak @entity19 were restricted exclusively by @entity19665 . Considered in the context of the avidity theory of T cell activation and selection, the reported poor peptide binding capacity of NOD @entity19665 suggested a new hypothesis to explain the effects of MHC class II expression on the peripheral autoimmune repertoire in NOD @entity19 . This new explanation suggests that the association of MHC with @entity6 results from "altered" thymic selection in which high affinity self-reactive (potentially autoreactive) T cells escape negative selection. This model offers an explanation for the requirement of homozygous MHC class II expression in NOD @entity19 (and in @entity1 ) in susceptibility to @entity1723 .

title: Analysis of the role of variation of major histocompatibility complex class II expression on nonobese XXXX (NOD) peripheral T cell response.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'mouse', 'transgenic mice']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['insulin-dependent diabetes mellitus']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic']


abstract: Abnormal columnar lining of the esophagus is a well-recognized @entity558 . The management of @entity1 with high-grade @entity1141 without evidence of @entity189 remains controversial. Esophagectomy is proposed by some investigators, whereas others favor follow-up endoscopy and biopsy until microinvasive @entity5 is documented. We reviewed our experience with nine @entity1 referred with high-grade @entity1141 on endoscopic biopsies without evidence of @entity189 . Eight @entity1 had the columnar lining extending orad from the @entity418 , and one @entity1 had heterotopic columnar epithelium in the cervical esophagus. All were white @entity1 ranging in age from 19 to 76 years (median: 47 years). Eight @entity1 underwent esophagectomy with colon interposition. A sleeve resection of the cervical esophagus was done in one @entity1 . @entity189 was found in three @entity1 , all of whom had severe @entity6349 changes throughout the columnar lining. The @entity1 with heterotopic columnar epithelium had @entity189 . All four @entity1 with @entity189 had negative nodes and are long-term survivors. No @entity189 was found in the resected specimens of the remaining five @entity1 . High-grade @entity1141 is an important marker of @entity5 in @entity1 with a @entity418 . Esophagectomy is indicated in suitable candidates since @entity189 was found in 45% of our @entity1 .

title: High-grade @entity1141 in the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['premalignant condition']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['microinvasive carcinoma', 'Multifocal carcinoma', 'carcinoma']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['cardia', 'columnar-lined esophagus']

entities_list: @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity418 :: (MESH:D004938,Disease) :: ['columnar-lined esophagus']


abstract: PURPOSE: On initial publication of GI Intergroup Radiation Therapy Oncology Group (RTOG) 98-11 [A Phase III Randomized Study of @entity1487 ( @entity1487 ), @entity1138 , and Radiotherapy Versus @entity1487 , @entity900 and Radiotherapy in @entity189 of the Anal Canal], concurrent chemoradiation (CCR) with @entity1487 (FU) plus @entity1138 ( @entity1139 ) @entity177 ( @entity177 ) when compared with induction plus concurrent FU plus @entity900 (CDDP), but did not significantly impact disease-free survival (DFS) or @entity1349 ( @entity1349 ) for anal canal @entity189 . The intent of the updated analysis was to determine the long-term impact of treatment on survival (DFS, @entity1349 , @entity1349 [ @entity1349 ]), @entity177 , and relapse (locoregional failure [LRF], distant @entity3 ) in this @entity1 group. @entity1 AND METHODS: Stratification factors included sex, clinical node status, and primary size. DFS and @entity1349 were estimated univariately by the Kaplan-Meier method, and treatment arms were compared by log-rank test. Time to relapse and @entity177 were estimated by the cumulative incidence method and treatment arms were compared by using Gray's test. Multivariate analyses used Cox proportional hazard models to test for treatment differences after adjusting for stratification factors. RESULTS: Of 682 @entity1 accrued, 649 were analyzable for outcomes. DFS and @entity1349 were statistically better for RT + FU/ @entity1139 versus RT + FU/CDDP (5-year DFS, 67.8% v 57.8%; P = .006; 5-year @entity1349 , 78.3% v 70.7%; P = .026). There was a trend toward statistical significance for @entity1349 (P = .05), LRF (P = .087), and @entity177 (P = .074). Multivariate analysis was statistically significant for treatment and clinical node status for both DFS and @entity1349 , for @entity5 diameter for DFS, and for sex for @entity1349 . CONCLUSION: CCR with FU/ @entity1139 has a statistically significant, clinically meaningful impact on DFS and @entity1349 versus induction plus concurrent FU/CDDP, and it has borderline significance for @entity1349 , @entity177 , and LRF. Therefore, RT + FU/ @entity1139 remains the preferred standard of care.

title: Long-term update of US GI intergroup RTOG 98-11 phase III trial for XXXX : survival, relapse, and @entity177 with concurrent chemoradiation involving @entity1487 / @entity1138 versus @entity1487 / @entity900 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients', 'PATIENTS']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin', 'Mitomycin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinoma', 'carcinoma']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['CF', 'decreased colostomy failure']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'CFS', 'colostomy-free survival', 'overall survival']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-Fluorouracil', 'fluorouracil', '5-FU']

answer: @entity189 :: (MESH:D002277,Disease) :: ['anal carcinoma']


abstract: The transcription factor nuclear factor of activated T cells (NFAT) resides in the cytoplasm in resting cells and upon stimulation is dephosphorylated, translocates to the nucleus, and becomes transcriptionally active. NFAT is commonly activated by stimulation of receptors coupled to @entity141 mobilization; however, little is known about the regulation of NFAT in pulmonary vascular smooth muscle. The aim of this study was to investigate regulation of NFAT in @entity1 and @entity35 intralobar pulmonary artery by two constrictors: @entity2647 (PE) and @entity15759 ( @entity15759 ), a @entity1447 metabolite formed endogenously in lungs. Immunostaining of smooth muscle cells revealed cytoplasmic localization of NFAT in untreated cells, and PE or @entity15759 induced translocation to the nucleus, with maximal effect at 30 min. @entity205 and @entity1140 (both 1 microM) inhibited NFAT translocation, indicating involvement of calcineurin. Moreover, the Rho-kinase blocker @entity12223 prevented translocation. Translocation of NFAT was confirmed by Western blots, with @entity17641 the prominent isoform in pulmonary artery. Constrictors caused calcineurin-sensitive translocation of NFAT to nuclei in intact arteries, demonstrating regulation in native tissue. To investigate a role for @entity141 , cells were loaded with @entity593 . Whereas PE caused an acute transient rise of [ @entity141 ](i), @entity15759 caused a prolonged low amplitude rise of [ @entity141 ](i). The involvement of Rho-kinase in PE- and @entity15759 -induced @entity17641 translocation in pulmonary artery suggests a level of control not previously recognized in smooth muscle. Constrictors of the pulmonary vasculature not only cause acute responses but also activate NFAT, which may alter gene expression in pulmonary health and disease.

title: Constrictor-induced translocation of XXXX in @entity1 and @entity35 pulmonary artery smooth muscle.

entities_list: @entity15759 :: ('MESH:C055987', 'Chemical') :: ['20-hydroxyeicosatetraenoic acid', '20-HETE']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporin A']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

answer: @entity17641 :: (4776,Gene) :: ['NFAT3']


abstract: OBJECTIVES: Viral oncogenes E6 and E7 are selectively retained and expressed in @entity189 cells infected with @entity1799 and cooperated with each other in immortalization and transformation of primary keratinocytes. This study was performed to identify proteins to be bound or modulated by high risk HPV E7 oncogene by using a proteomics. METHODS: HaCaT normal keratinocyte was prepared to establish a stable cell line expressing E7. The E7-affinity column was also prepared to obtain E7-interacting proteins. In order to search the target molecules modulated by E7 expression, we used 2-dimensional electrophoresis and matrix-assisted laser desorption/ionization time of flight (MALDI/TOF) mass spectrometry. Pull down assay was also performed in order to confirm the E7-interacting proteins. RESULTS: We identified 28 spots that are modulated by E7 in HaCaT/E7 using 2-dimensional electrophoresis (2-DE) and MALDI/TOF mass spectrometry. Proteomics analyses showed that actin and leukocyte elastase inhibitor were down-regulated, whereas @entity31654 , @entity51386 , @entity2196 , T-complex protein 1, Ku70-binding protein, heat shock 60 kDa protein 1, G1/S-specific @entity9654 and @entity20385 were up-regulated. Western blot revealed that heat shock 60 kDa protein, @entity2196 and @entity20385 were also up-regulated. Pull down assay also showed that leukocyte elastase inhibitor (LEI) and Ku70-binding protein were bound to the E7 oncoprotein. By using E7-affinity column and 2-DE/MALDI-TOF, 22 spots were found to interact with E7 recombinant protein. MG11-like proteins, @entity22769 , protein @entity563 kinase @entity27666 , @entity51386 , @entity9654 , TATA box binding protein-associated factor and @entity6683 - @entity3183 kinase 2 were up-regulated by E7 oncogene and also bound to E7 oncoprotein. CONCLUSIONS: It is presumed that E7 can influence cell status by modulating the factors related to cell signaling, apoptosis and cell cycle regulation.

title: Protein profiling and identification of modulators regulated by XXXX E7 oncogene in HaCaT keratinocytes by proteomics.

entities_list: @entity31654 :: ('10963', 'Gene') :: ['stress-induced phosphoprotein 1']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1799 :: ('333760', 'Species') :: ['human papillomavirus type 16']

entities_list: @entity3183 :: ('MESH:D003562', 'Chemical') :: ['cytidine']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity22769 :: ('79444', 'Gene') :: ['livin inhibitor-of-apoptosis']

answer: @entity1799 :: (333760,Species) :: ['human papillomavirus 16']


abstract: BACKGROUND: The literature lacks electromyographic (EMG) examination of subscapularis function in the postoperative period after @entity348 ( @entity348 ). The primary purpose of this study was to document EMG activity of the subscapularis after @entity348 and to correlate it with clinical and ultrasound findings. METHODS: The study included 30 @entity1 who were at least 1 year (average, 2.1 years) from surgery, status post @entity348 approached through a standard subscapularis tenotomy. @entity1 returned for a physical examination, ultrasound evaluation, and EMG evaluation. @entity1 also completed postoperative surveys: the American Shoulder and Elbow Surgeons questionnaire, the Simple Shoulder Test, and the 12-Item Short Form Health Survey. RESULTS: The American Shoulder and Elbow Surgeons, Simple Shoulder Test, and physical 12-Item Short Form Health Survey scores improved from preoperatively to postoperatively, respectively, 45.3 to 76.8 (P   =   .0002), 3.9 to 9.0 (P   <   .0001), and 33.9 to 42.8 (P   =   .017). Six @entity1 had a positive lift-off test result, and the belly-press test result was negative in all @entity1 . Two @entity1 had a subscapularis rupture on ultrasound. The postoperative EMG finding was normal in 15 @entity1 ; in the other 15 @entity1 , there was evidence of chronic denervation with reinnervation changes: 30% subscapularis, 27% infraspinatus, 20% supraspinatus, 20% teres minor, and 13% rhomboids. CONCLUSIONS: This is the first study using a comparison EMG evaluation to document subscapularis function after @entity348 . EMG evaluation showed that active denervation of the subscapularis was not evident in any @entity1 at least 1 year after @entity348 . However, in half of the @entity1 , there was evidence of chronicdenervation and reinnervation changes across 5 muscle groups. We theorize that surgical exposure, traction, and the use of interscalene regional anesthesia may contribute to these unexpected EMG results.

title: Subscapularis function after XXXX : electromyography, ultrasound, and clinical correlation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['total shoulder arthroplasty', 'TSA']

answer: @entity348 :: (MESH:C535338,Disease) :: ['total shoulder arthroplasty']


abstract: OBJECTIVE: To understand the dynamics of schistosome antibodies in population in mountainous @entity2040 low endemic regions, China, so as to provide the evaluation reference for immunodiagnosis. METHODS: The @entity1 who consecutively received the indirect heamagglutination assay (IHA) for @entity2040 and Kato-Katz technique were enrolled in this study in Guixiang Village, Danling County, Sichuan Province from 2006 to 2011. The positive rates for schistosome antibodies, antibody titers and eggs per gram (EPG) were analyzed. RESULTS: A total of 353 @entity1 were investigated in this study from 2006 to 2011. The positive rates for schistosome antibodies decreased from 20.73% to 13.67%, and the geometric mean reciprocal titer (GMRT) decreased from 1.63 to 1.06. The antibodies tended to be negative in most antibody-positive @entity1 and the GMRT decreased gradually. The antibodies remained negative in most antibody-negative @entity1 . After chemotherapy in parasitology confirmed @entity1 , the positive rate for schistosome antibodies decreased from 100% to 20%, and the GMRT decreased from 34.29 to 1.58. There was a highly positive correlation between GMRT and EPG (r = 0.94, P < 0.05). CONCLUSION: The positive rate for schistosome antibodies in population in mountainous @entity2040 low endemic regions is relatively high (13.67%). The standardization of immunodiagnostic methods is necessary and the suitable diagnostic reagents should be developed in this region.

title: [Surveillance of schistosome antibodies in population in mountainous XXXX endemic regions in China].

entities_list: @entity1 :: ('9606', 'Species') :: ['people', 'patients']

entities_list: @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis']

answer: @entity2040 :: (MESH:D012552,Disease) :: ['schistosomiasis']


abstract: Three plasmids from @entity1336 G63, pG6301, pG6302 and pG6303, were sequenced and have molecular sizes of 3516-bp, 9112-bp and 10047-bp, respectively. We determined the replicons of these plasmids. The pG6301 plasmid carried a replication gene that functioned by the rolling-circle replication mechanism. The @entity47442 protein of pG6302 shared extremely low similarity with a reported plasmid, pLME300, which replicated by a bi-directional mechanism. Both the @entity47442 protein and OriV analyses indicated a similar replication mechanism in pG6302. Conversely, we found neither the @entity47442 protein nor OriV when we analyzed the whole sequence of pG6303. This finding may illustrate a novel replication mechanism. Additionally, the transposon, a mobilization element, was analyzed and compared to a similar insertion sequence (IS) element. A predicted lysozyme gene, pG6303 guhA, was heterologously expressed, but no activity was detected. The pG6302 and pG6303 plasmids contain new replicons and may be useful vector candidates for future molecular manipulation of @entity1336 .

title: Characterization of three cryptic plasmids from XXXX G63 that was isolated from Chinese pickle.

entities_list: @entity1336 :: ('1590', 'Species') :: ['L. plantarum', 'Lactobacillus plantarum']

answer: @entity1336 :: (1590,Species) :: ['Lactobacillus plantarum']


abstract: BACKGROUND: @entity1569 is associated with a variety of comorbidities such as @entity28 and @entity65 . OBJECTIVE: In a cross-sectional study, we explored whether @entity27 ( @entity27 ) is associated with @entity1569 characteristics and metabolic parameters. METHODS: Thirty-five @entity1 with chronic @entity1569 underwent a nocturnal polysomnography study and were analysed for Apnoea-Hypopnoea Index to assess @entity27 severity and Framigham score to predict the absolute risk of @entity453 at 10 years. The association of @entity27 with @entity1569 was examined according to @entity1569 characteristics (PASI and DLQI scores, disease duration and previous use of systemic treatments), metabolic parameters (Body Mass Index - BMI, waist to hip ratio - WHR, lipid profile) and other comorbidities ( @entity28 , @entity101 , @entity625 and @entity65 ). RESULTS: There was no correlation between @entity1569 characteristics and @entity27 . @entity1569 @entity1 with @entity27 presented more frequent snoring and lower @entity25 compared with those without @entity27 . In univariate analyses, @entity27 was associated with increased BMI and @entity101 in @entity1569 @entity1 . In multivariable logistic regression models, there was statistically significant evidence that only BMI and @entity101 were associated with increased risk of @entity27 , adjusting for @entity1569 characteristics, age and gender. Presence of @entity209 , WHR, and smoking were not significant risk factors for @entity27 . In subgroup analyses, @entity27 correlated with duration of @entity1569 (>8 years) in @entity1 (P = 0.021) and with Framigham score in @entity1 (P = 0.035). CONCLUSION: @entity27 may be a comorbidity in @entity28 @entity1 with @entity101 . Treatment with continuous positive airway pressure and weight loss interventions should be initiated.

title: Sleep apnea as a comorbidity in @entity28 @entity1 : a cross-sectional study. Do XXXX characteristics and metabolic parameters play a role?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['Psoriasis', 'psoriasis', 'plaque psoriasis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese psoriasis', 'obesity']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep quality']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['OSAHS', 'obstructive sleep apnea and hypopnea syndrome']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: OBJECTIVE: The effectiveness of use of migrant health educators in the general practitioners' care for female migrants with @entity5539 problems was evaluated to contribute to the improvement of the care for these @entity1 . METHODS: A randomised controlled trial (RCT) design was used. A total of 104 @entity1 (75%) agreed to take part in the intervention study. The @entity1 were from Turkish and Moroccan immigrant groups living in The Netherlands. The intervention group received counselling and education from the migrant health educators as adjuncts to the GPs' care. Special attention was given to the @entity1 's cultural background, supporting the communication between GP and @entity1 . The control group received regular treatment from their GPs. RESULTS: A significant improvement of perceived general health, psychological health and reported ability to cope with @entity158 was observed among the intervention group. No effects were found for social support and the perceived burden of stressful life-events. CONCLUSION: The @entity1 ' perceived health and coping abilities improved through the intervention as a whole. Not all outcome measures had been affected due to among others the diversity of physical and @entity458 the @entity1 suffered from, non-compliance and a perceived decrease of disability over time. PRACTICE IMPLICATIONS: The intervention methods should be integrated in the @entity1 care delivery for migrants in general practice. Further development of intervention methods to address the @entity1 ' social support is recommended.

title: Effects of health education for migrant females with XXXX complaints treated by general practitioners. A randomised controlled evaluation study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5539 :: ('MESH:D011602', 'Disease') :: ['psychosomatic']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological complaints']

answer: @entity5539 :: (MESH:D011602,Disease) :: ['psychosomatic']


abstract: Transcatheter aortic valve implantation with the self-expandable CoreValve (CV) and the balloon-expandable Edwards SAPIEN (ES) bioprostheses has been widely used for the treatment of severe @entity472 . However, a direct comparison of the hemodynamic results associated with these 2 prostheses is lacking. The aim of the present study was to compare the hemodynamic performance of both bioprostheses. A total of 41 @entity1 who underwent transcatheter aortic valve implantation with the CV prosthesis were matched 1:1 for prosthesis size (26 mm), aortic annulus size, left ventricular ejection fraction, body surface area, and body mass index with @entity1 who underwent transcatheter aortic valve implantation with the ES prosthesis. Doppler-echocardiographic data were prospectively collected before the intervention and at hospital discharge, and all examinations were sent to, and analyzed in, a central echocardiography core laboratory. The mean transprosthetic residual gradient was lower (p = 0.024) in the CV group (7.9    3.1 mm Hg) than in the ES group (9.7    3.8 mm Hg). The effective orifice area tended to be greater in the CV group (1.58    0.31 cm(2) vs 1.49    0.24 cm(2), p = 0.10). The incidence of severe prosthesis- @entity1 mismatch was, however, similar between the 2 groups (effective orifice area indexed to the body surface area  <=0.65 cm(2)/m(2); CV 9.8%, ES 9.8%, p = 1.0). The incidence of @entity337 was greater with the CV (grade 1 or more in 85.4%, grade 2 or more in 39%) than with the ES (grade 1 or more in 58.5%, grade 2 or more in 22%; p = 0.001). The number and extent of @entity2478 were greater in the CV group (p <0.01 for both comparisons). In conclusion, transcatheter aortic valve implantation with the CV prosthesis was associated with a lower residual gradient but a greater rate of @entity337 compared to the ES prosthesis. The potential clinical consequences of the differences in hemodynamic performance between these transcatheter heart valves needs to be addressed in future studies.

title: Comparison of hemodynamic performance of self-expandable CoreValve versus balloon-expandable Edwards SAPIEN aortic valves inserted by catheter for XXXX .

entities_list: @entity2478 :: ('MESH:D019559', 'Disease') :: ['paravalvular leaks']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['paravalvular aortic regurgitation']

answer: @entity472 :: (MESH:D001024,Disease) :: ['aortic stenosis']


abstract: OBJECTIVE: To evaluate the efficacy of a brief cognitive-behavioral therapy (CBT) that is being developed for management of @entity73 following chemotherapy among @entity0 survivors. Memory and Attention Adaptation Training (MAAT) is a brief CBT designed to improve the quality of life and function among @entity5 survivors with post-chemotherapy cognitive complaints. METHODS: An initial, two-group (MAAT versus waitlist, no treatment control), randomized clinical trial (RCT) was conducted. Forty stage I and II female @entity0 survivors (mean age = 50; SD = 6.4) were randomized to conditions and assessed at baseline, post-treatment (8 weeks) and 2-month follow-up assessment points on measures of: (1) self-reported daily cognitive failures; (2) quality of life; and (3) neuropsychological performance. @entity1 were also assessed for satisfaction with MAAT. RESULTS: With education and IQ as covariates, MAAT @entity1 made significant improvements relative to controls on the spiritual well-being subscale of the quality of life measure and on verbal memory, but statistical significance was not achieved on self-report of daily cognitive complaints. However, moderate-to-large effect sizes were observed on these outcomes. @entity1 gave MAAT high satisfaction ratings. CONCLUSIONS: Although this initial RCT is a small study, MAAT @entity1 appear to improve on one measure of quality of life and verbal memory performance relative to no treatment controls and rate MAAT with high satisfaction. These data are encouraging and support the continued development and evaluation of MAAT efficacy.

title: Development of CBT for chemotherapy-related XXXX : results of a waitlist control trial.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive change']


abstract: BACKGROUND: A high-fat diet is a risk factor for the development of @entity29 ( @entity29 ) in @entity1 . @entity6743 ( @entity4420 ) is increased in the colonic contents in response to a high-fat diet. Thus, an elevated level of @entity4420 in the colonic lumen may play a role in the natural course of development of @entity29 . METHODS: Wild-type B6.129 @entity19 were fed an AIN-93G diet, either supplemented with 0.2% @entity4420 or unsupplemented and sacrificed at 1 week, 1 month, 3 months, 4 months, and 8 months. Colon samples were assessed by histopathological, immunohistochemical, and cDNA microarray analyses. RESULTS: @entity19 fed the @entity4420 -supplemented diet developed focal areas of @entity32 associated with increases in angiogenesis, nitrosative stress, DNA/RNA damage, and proliferation. Genes that play a central role in @entity32 and angiogenesis and other related processes such as epithelial barrier function, oxidative stress, apoptosis, cell proliferation/cell cycle/DNA repair, membrane transport, and the ubiquitin-proteasome pathway showed altered expression in the @entity4420 -fed @entity19 compared with the control @entity19 . Changes in expression of individual genes (increases or reductions) correlated over time. These changes were greatest 1 month after the start of @entity4420 feeding. CONCLUSIONS: The results suggest that exposure of the colonic mucosa to @entity4420 may be a key etiologic factor in @entity29 . The @entity4420 -fed @entity19 model may reflect the natural course of development of @entity1960 / @entity29 in @entity1 , and thus may be useful for determining new preventive strategies and lifestyle changes in affected individuals.

title: Unique dietary-related @entity19 model of XXXX .

entities_list: @entity6743 :: ('MESH:D003840', 'Chemical') :: ['Deoxycholate']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['colonic inflammation', 'inflammation']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease', 'IBD']

answer: @entity1960 :: (MESH:D003092,Disease) :: ['colitis']


abstract: OBJECTIVE: @entity6 has become the leading cause of @entity454 ( @entity454 ). Renal risk stratification could assist in earlier identification and targeted prevention. This study aimed to derive risk models to predict @entity454 events in type 2 @entity6 in primary care. RESEARCH DESIGN AND METHODS: The nationwide derivation cohort included adults with type 2 @entity6 from the New @entity6 Cohort Study initially assessed during 2000-2006 and followed until December 2010, excluding those with pre-existing @entity454 . The outcome was fatal or nonfatal @entity454 event (peritoneal dialysis or hemodialysis for @entity454 , renal transplantation, or @entity204 from @entity454 ). Risk models were developed using Cox proportional hazards models, and their performance was assessed in a separate validation cohort. RESULTS: The derivation cohort included 25,736 individuals followed for up to 11 years (180,497 @entity1 -years; 86% followed for >= 5 years). At baseline, mean age was 62 years, median @entity6 duration 5 years, and median HbA1c 7.2% (55 mmol/mol); 37% had @entity633 ; and median estimated glomerular filtration rate (eGFR) was 77 mL/ @entity1009 .73 m2. There were 637 @entity454 events (2.5%) during follow-up. Models that included sex, ethnicity, age, @entity6 duration, @entity633 , serum @entity1011 , systolic blood pressure, HbA1c, smoking status, and previous @entity65 status performed well with good discrimination and calibration in the derivation cohort and the validation cohort (n=5,877) (C-statistics 0.89-0.92), improving predictive performance compared with previous models. CONCLUSIONS: These 5-year renal risk models performed very well in two large primary care populations with type 2 @entity6 . More accurate risk stratification could facilitate earlier intervention than using eGFR and/or @entity633 alone.

title: Derivation and validation of a renal risk score for XXXX with type 2 @entity6 .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'Zealand Diabetes', 'diabetes']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: OBJECTIVE: To assess the efficacy of open excision as an alternative to tracheostomy in the management of @entity2695 . DESIGN: A retrospective review of @entity1 undergoing open surgical excision of @entity2695 over a 10-year period. SETTING: A tertiary pediatric center. @entity1 : The study included 22 @entity1 ranging in age from 2 to 42 months (median age, 5 months) who underwent open excision of @entity2695 over a 10-year period. RESULTS: Twenty-one @entity1 were treated with single-stage procedures, with postoperative endotracheal intubation for an average of 5 days. One @entity1 who had a preexisting tracheostomy was treated with a 2-stage procedure and underwent decannulation 2 months after excision. Seven other @entity1 were tracheostomy dependent at the time of excision and underwent decannulation at the time of the procedure. Cartilage grafts were inserted in 10 @entity1 . There were no problems with @entity5142 . Twenty-one @entity1 reported good voice and no airway symptoms after a mean follow-up period of 42 months. Five @entity1 had significant postoperative problems. Three @entity1 required further endoscopic procedures for removal of granulation tissue, and 1 @entity1 , who remains minimally symptomatic, developed an anterior glottic web. One @entity1 required a 6-month course of @entity230 after surgery to treat residual glottic @entity2695 . CONCLUSIONS: Open surgical excision of @entity2695 can be performed as a single procedure, avoiding a tracheostomy, when modern surgical techniques developed for laryngotracheal reconstruction are incorporated. This approach can avoid repeated endoscopic procedures, prolonged treatment with @entity288 , and years spent with a tracheostomy waiting for spontaneous involution of the @entity2695 .

title: Open excision of XXXX to avoid tracheostomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'PATIENTS']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['subglottic hemangiomas', 'hemangioma', 'subglottic hemangioma']

entities_list: @entity5142 :: ('MESH:D007829', 'Disease') :: ['subglottic stenosis']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity2695 :: (MESH:D006391,Disease) :: ['subglottic hemangiomas']


abstract: In @entity1 with @entity1150 or @entity1151 , initial treatment with low-molecular-weight heparin (LMWH) is primarily aimed at preventing @entity715 extension. After this initial phase, the goal of treatment is to prevent recurrences, which can be fatal. Is it better to continue treatment of @entity1150 or @entity1151 with LMWH or switch to an oral anticoagulant? What is the optimal duration of treatment? To answer these questions, we conducted a review of the literature using the standard Prescrire methodology. In @entity5 @entity1 , two meta-analyses of trials in which treatment was not double blinded showed that severe @entity548 was slightly less frequent with LMWH than with a @entity2067 antagonist, but no data on mortality or the recurrence rate were provided. In @entity5 @entity1 , LMWH prevented more recurrences than @entity2067 antagonists; LMWH did not reduce overall mortality and did not increase the risk of serious @entity548 compared to @entity2067 antagonists. Treatment with LMWH requires daily injections and renal monitoring.Treatment with @entity1229 , the standard @entity2067 antagonist, requires regular INR monitoring. There is no evidence that @entity3925 or @entity3926 has a better harm-benefit balance than @entity1229 for long-term treatment. After a first episode of proximal @entity1150 or @entity1151 associated with an identified reversible trigger, several meta-analyses support a 3-month course of anticoagulation. Prolonged anticoagulant therapy is generally considered when there is no identified trigger or in case of a recurrence. Two double-blind randomised placebo-controlled trials failed to establish whether or not @entity117 -based antiplatelet therapy given after discontinuation of anticoagulant therapy has a favourable harm-benefit balance. Various clinical practice guidelines published since 2006 recommend first-line treatment with a @entity2067 antagonist for at least 3 months in @entity1 without @entity5 , and continuation of LMWH therapy in @entity1 with @entity5 . Overall, LMWH and @entity1229 have similar harm-benefit balances. In practice, it is best to choose between these drugs on a case-by-case basis, taking into account @entity1 preferences, monitoring constraints, difficulty controlling the INR, the risk of @entity548 and interactions, and the cost of treatment.

title: @entity1150 and XXXX . Part 2--Prevention of recurrences: @entity1229 or low-molecular-weight heparin for at least 3 months.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'non-cancer']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis']

entities_list: @entity3926 :: ('MESH:C554682', 'Chemical') :: ['dabigatran']

entities_list: @entity3925 :: ('MESH:C503223', 'Chemical') :: ['rivaroxaban']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

answer: @entity1151 :: (MESH:D011655,Disease) :: ['pulmonary embolism']


abstract: BACKGROUND AND OBJECTIVES: The aim of this study was to determine whether an intrabursal @entity1286 and @entity1341 mixed infusion provides useful @entity1337 for prolonged @entity158 relief after subacromial arthroscopic operation. METHODS: A continuous intrabursal infusion catheter was inserted at the conclusion of the subacromial arthroscopic operation that was performed under general anesthesia. In a prospective, double-blind, randomized trial, 60 @entity1 were divided into 2 groups: an anesthetic group received 5 mL of mixed 0.5% @entity1341 , 2 mg of @entity1286 , 0.05 mL of 1/1,000 epinephrine as a bolus, and a solution of 40 mL of a 0.5% @entity1341 and 8 mg of @entity1286 mixture that was used as a maintenance dose at a constant rate of 0.5 mL/h. This was done by means of a continuous infusion pump (0.5 mL hourly). A saline group (n = 30) received continuous saline infusion. Two @entity1 were eliminated from the study because of @entity1212 or malfunction in the saline group. The intensity of the @entity158 was evaluated preoperatively and postoperatively for 3 days by a graded visual analog scale (score from 0 to 10) for night @entity158 , @entity158 on motion, @entity25 , lying on painful shoulder, and the amounts of supplemental analgesics. RESULTS: @entity158 was decreased on the first and second postoperative day, and there was less @entity25 for 3 days postoperatively in the anesthetic group. There was no difference in @entity158 caused by movement postoperatively. In the anesthetic group, lesser amounts of analgesics were used in the first 48 hours postoperatively. CONCLUSIONS: The continuous intrabursal infusion method resulted in a decreased perception of @entity158 and reduced supplemental analgesics requirement for 2 days postoperatively.

title: The efficacy of continuous intrabursal infusion with @entity1286 and @entity1341 for postoperative XXXX after subacromial arthroscopy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter leakage']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['rest pain', 'Pain', 'pain']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance']

answer: @entity1337 :: (MESH:D000699,Disease) :: ['analgesia']


abstract: <AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Questions remain about whether inflammation is @entity32 sequence, or coincidence of aging. The purpose of this study was to define baseline immunological characteristics from blood to develop a model in rhesus macaques @entity2608 sed to address the relationship between inflammation and @entity32 tology, flow cytometry, clinical chemistry, and multiplex cytokine/chemokine analyses were performed on a group of 101 outdoor-housed captive rhesus macaques @entity2608 to 24 years of age, approximately equivalent to 8 to 77 years of age in humans. RESULTS: @entity1 results extend earlier reports correlating changes in lymphocyte subpopulations and cytokines/chemokines with increasing age. There were significant declines in numbers of white blood cells (WBC) overall, as well as lymphocytes, monocytes, and polymorphonuclear cells with increasing age. Among lymphocytes, there were no significant declines in NK cells and T cells, whereas B cell numbers exhibited significant declines with age. Within the T cell populations, there were significant declines in numbers of CD4+ na  ve T ce @entity8888 and CD8+ na  ve T cells. Conversely, numbers of CD4+CD8+ effecto @entity8888 emory and CD8+effector memory T cells increased with age. New multiplex analyses revealed that concentrations of a panel of ten circulating cytokines/chemokines, IFNy, IL1b, IL6, IL12, @entity41421 5, @entity51337 Fa, MCP1 @entity51338 P1 @entity51339 L1 @entity51340 an @entity51341 , each signif @entity51342 ntly correlated with age and also exhibited concordant pairwise correlations with every other factor within this group. To also control for outlier values, mean rank values of each of these cytokine concentrations in relation to age of each animal and these also correlated with age. CONCLUSIONS: A panel of ten cytokines/chemokines were identified that correlated with aging and also with each other. This will permit selection of animals exhibiting relatively higher and lower inflammation sta @entity32 el to test mechanisms of inflammation sta @entity32 with susceptibility to infections and vaccine efficacy.

title: Immune correlates of aging in outdoor-housed captive XXXX ( @entity2608 ).

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2608 :: ('9544', 'Species') :: ['rhesus macaques']

answer: @entity2608 :: (9544,Species) :: ['rhesus macaques']


abstract: OBJECTIVE: To determine whether @entity887 of pelvic @entity1317 before open reduction and internal fixation (ORIF) of @entity174 is associated with an increased rate of deep @entity281 . METHODS: Retrospective review of @entity1 who underwent ORIF of @entity174 at our institution from 1995 through 2007 (n = 1440). We compared @entity1 with @entity174 who underwent angiography and @entity887 of a pelvic artery (n = 12) with those who underwent angiography but did not undergo @entity887 (n = 14). Primary outcome was presence of @entity281 requiring return to the operating room. RESULTS: Seven (58%) of the 12 @entity1 who underwent @entity887 developed deep @entity281 compared with only 2 (14%) of the @entity1 who underwent angiography but did not require pelvic vessel @entity887 (P < 0.05, Fisher exact test). CONCLUSIONS: The combination of an @entity174 that requires ORIF and a pelvic @entity1317 that requires angiographic @entity887 is rare. However, the 58% @entity281 rate of the @entity1 who underwent @entity887 before ORIF is an order of magnitude higher than typical historical controls (2%-5%) and significantly higher than that of the control group of @entity1 who underwent angiography without @entity887 (14%). In addition, a disproportionate number of the @entity1 who developed @entity281 had their entire internal iliac artery embolized. Surgeons should be aware that @entity887 of a pelvic @entity1317 is associated with a high rate of @entity281 after subsequent ORIF of an @entity174 . Embolization of the entire iliac artery should be avoided whenever possible. LEVEL OF EVIDENCE: Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.

title: Embolization of pelvic XXXX is a risk factor for @entity281 after @entity174 surgery.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['acetabular fractures', 'acetabular fracture']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'surgical site infection']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolization']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury', 'arterial injuries']

answer: @entity1317 :: (MESH:D057772,Disease) :: ['arterial injury']


abstract: BACKGROUND AND PURPOSE: Vascular risk factors are suboptimally managed internationally. This study investigated time trends in risk factors diagnosed before @entity64 and their treatment, and factors associated with appropriate medication use. METHODS: A total of 4416 @entity1 with a first @entity64 were registered in the population-based South London @entity64 Register from 1995 to 2011. Previously diagnosed risk factors and usual medications were collected from @entity1 ' primary care and hospital records. Trends and associations were assessed using multivariate logistic regression. RESULTS: Seventy-two percent of @entity1 were diagnosed previously with 1 or more risk factors; 30% had diagnosed risk factors that were untreated. @entity1007 increased significantly during the study period; @entity583 and transient @entity63 attack prevalences decreased. Antiplatelet prescription increased in @entity955 ( @entity955 ), @entity583 , and transient @entity63 attack ( @entity955 , 37%-51%, P<0.001; @entity583 , 48%-69%, P<0.001; transient @entity63 attack, 49%-61%, P=0.015). Anticoagulant prescription for @entity955 showed a nonsignificant increase (12%-23%; P=0.059). Fewer older @entity1 with @entity955 were prescribed anticoagulants (age, >85 versus <65 years; adjusted relative risk, 0.19; 95% confidence interval, 0.08-0.41). Black ethnicity (adjusted relative risk, 1.17; 95% confidence interval, 1.10-1.23) and female sex (adjusted relative risk, 1.09; 95% confidence interval, 1.03-1.15) were associated with increased antihypertensive drug prescription; other medications did not vary by ethnicity or sex. CONCLUSIONS: Antiplatelet and @entity165 -lowering treatment prescribing have improved significantly over time; however, only a minority with @entity955 received anticoagulants, and this did not improve significantly. Overall, 30% of @entity64 occurred in @entity1 with previously diagnosed but untreated risk factors.

title: Trends in risk factor prevalence and management before first XXXX : data from the South London @entity64 Register 1995-2011.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke', 'Stroke']

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['Hypercholesterolemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: PURPOSE: On the basis of a retrospective review, we aimed to clarify the optimum extent of lymph node dissection in @entity1 with @entity7487 and @entity18246 @entity14 . METHODS: We reviewed medical records of 487 @entity1 with @entity7487 and 351 @entity1 with @entity18246 @entity14 , who had undergone curative surgery. RESULTS: In @entity1 with @entity7487 @entity5 , results of pathologic examination showed either no lymph node @entity3 or @entity3 within the paracolic or pararectal region in 284 (98.3 percent) of 289 @entity1 with @entity694 and 195 (98.5 percent) of 198 with @entity5 . Of 459 @entity1 without clinically evident @entity3 , only one @entity1 with a poorly differentiated @entity420 had @entity3 beyond the paracolic area. In 28 @entity1 with @entity7487 @entity5 and clinically diagnosed node @entity3 , pathologic examination showed that node involvement did not extend beyond the named vessel in 26. Among @entity1 with cT2tumors, 97.5 percent of @entity1 with @entity694 and 95.9 percent with @entity5 had no or limited @entity3 . Of 276 without clinically evident @entity3 , none had node @entity3 at the roots of the named vessels; of 75 with clinically evident @entity3 , none had pathologic extension beyond the roots of the named vessels. CONCLUSIONS: In @entity7487 @entity1 with cN-negative @entity14 , @entity1600 may be optimal; in those with cN positivity, the regional nodes along the named vessels should be dissected. In @entity18246 @entity1 who are cN-negative, dissection of the regional nodes may be optimal. For those with cN positivity, dissection at the roots of the named vessels should be considered.

title: Optimum lymph node dissection in clinical T1 and clinical T2 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal tumors', 'tumors']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['paracolorectal lymph node dissection']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal tumors', 'colorectal cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon tumors']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: We investigated the antiproliferative and antiinflammatory effects of @entity1499 ( @entity1500 ) on differentiating/differentiated cells, namely cultured @entity1 monocytic myeloid cells ( @entity1357 ), and primary cultures of synovial macrophages from @entity1 with @entity309 ( @entity309 ). METHODS: We evaluated early and late apoptosis as well as natural cytokine inhibitor production, such as the @entity1193 ( @entity1193 ) and the soluble @entity5 necrosis factor receptor (sTNFr). RESULTS: Within @entity1357 cells we observed a significant (p < 0.001) dose-dependent inhibition of proliferation (at 24-48 and 72-96 h) and a significant presence of apoptosis (at 24-48 h) with @entity1500 concentrations of 500, 100, and 75 microg/ml compared with untreated controls. No significant changes were observed with 5 microg/ml or 500 to 50, and 5 ng/ml. A significant increase of @entity1193 (p < 0.001) was observed with @entity1500 concentrations of 5 microg (51.43 +/- 2.53 vs 16.22 +/- 5.19 pg/ml control) and 500 ng (36.43 +/- 3.3 vs 16.22 +/- 5.19 pg/ml control) at all the tested times. No significant changes were observed for the sTNFr p75. Evaluating the @entity309 synovial macrophages, we obtained no significant effects on cell proliferation and apoptosis with @entity1500 treatment at 24 h and at the concentration of 50 microg/ml (achievable in the serum with low dose @entity1500 treatment in @entity309 ). No significant changes were observed for the @entity1193 and no detectable levels for the sTNFr p75 were detected after treatment with @entity1500 . CONCLUSION: This study shows that the antiproliferative and antiinflammatory effects of @entity1500 on @entity1 cultured monocytes are dose-dependent. The antiproliferative activity seems to be mediated by cell apoptosis and the antiinflammatory activity seems to be related to cytokine inhibitor release.

title: Antiproliferative and antiinflammatory effects of @entity1499 on cultured differentiating myeloid monocytic cells ( XXXX ) but not on synovial macrophages from @entity1 with @entity309 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1193 :: ('3557', 'Gene') :: ['interleukin 1 (IL-1) receptor antagonist', 'IL-1ra']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity1357 :: (2736,Gene) :: ['THP-1']


abstract: OBJECTIVE: Immunohistochemical techniques have revealed the presence of @entity7 ( @entity7 ) in the epidermis of @entity1 with @entity102 ( @entity102 ). Our objective was to perform a quantitative analysis of the @entity7 gene transcription in tissues that are potential sources of this factor (skin, varicose veins [VV] and great saphenous vein [GSV]) in @entity1 with @entity102 . METHODS: In all, 212 skin and venous tissue samples were collected from @entity1 diagnosed with @entity102 and controls. The @entity7 gene expression was analysed using quantitative realtime polymerase chain reaction (PCR). RESULTS: The skin @entity7 expression was lower in the @entity102 group than in the control group (P = 0.04). There were no significant differences between the insufficient GSV of the @entity102 group and the control healthy vein (P = 0.22). There was a greater expression of @entity7 in the VV of the @entity102 group than in the control healthy vein (P = 0.03). Comparison of the @entity7 expression between the different tissue types in the @entity102 group revealed significant differences between the skin and GSV (P = 0.02) and between the skin and the VV (P = 0.004), and between the VV and the GSV (P = 0.02). CONCLUSIONS: The results of the present study show an over-expression of @entity7 gene in the VV tissue of @entity1 with @entity102 . Based on the data in @entity1 with @entity1605 , the VVs appear to be the source of increased @entity7 expression.

title: Analysis of @entity7 gene expression in the tissues of XXXX with chronic venous insufficiency.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic venous disease', 'CVD']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Marriages between third-degree and more distant relatives are common in many parts of the world. Offspring of consanguineous parents have increased morbidity and mortality related to @entity74 . In a population with a high frequency of consanguinity, we examined the frequency of @entity0 (related in part to tumour genes) and cervical cancers (related to @entity778 ) among offspring of consanguineous and non-consanguineous parents. Study was done prospectively in the United Arab Emirates. Selected were married female citizens, ages 40-65, who attended 12 primary health care clinics for whatever reason. In a face-to-face interview, subjects were asked: (a) about consanguineous marriages in family; (b) if they have or have had @entity0 ; (c) about family history of @entity5 , @entity5 screening and other parameters. @entity5 diagnosis was confirmed by review of medical records. Of 1750 @entity1 invited into study, 1445 (79%) could be used in analysis. Among 579 (40%) @entity1 of consanguineous and 866 (60%) of non-consanguineous parents there were 24 and 54 with @entity0 , respectively (RR = 0.66, CI 0.42 - 1.06). In the 40 to 50 age group, @entity0 reported 13 of 446 @entity1 of consanguineous and 37 of 633 of non-consanguineous parents (RR = 0.50, Cl 0.27 - 0.93). @entity5 had 15 @entity1 in consanguineous and 32 in non-consanguineous group (RR = 0.70, Cl 0.38 - 1.28). Number of families with history of @entity0 in consanguineous and non-consanguineous group was 21 and 23, respectively (P = 0.29). The @entity5 screening rates and other variable values had fairly balanced distribution between the 2 groups. Having consanguineous parents decreases the risk of @entity0 especially in younger @entity1 , risk of cervical @entity5 being unaffected.

title: Consanguinity decreases risk of XXXX unaffected.

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['virus infection']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast or cervical cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'cancer', 'Cervical cancer']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['recessive gene disorders']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer--cervical cancer']


abstract: Traffic from the endoplasmic reticulum (ER) to the Golgi complex is initiated when the activated form of the GTPase @entity46724 recruits the Sec23p- @entity46725 complex to ER membranes. The Sec23p- @entity46725 complex, which forms the inner shell of the COPII coat, sorts cargo into ER-derived vesicles. The coat inner shell recruits the @entity46726 -Sec31p complex, leading to coat polymerization and vesicle budding. Recent studies revealed that the Sec23p subunit sequentially interacts with three different binding partners to direct a COPII vesicle to the Golgi. One of these binding partners is the @entity563 / @entity1889 kinase Hrr25p. Hrr25p phosphorylates the COPII coat, driving the membrane-bound pool into the cytosol. The phosphorylated coat cannot rebind to the ER to initiate a new round of vesicle budding unless it is dephosphorylated. Here we screen all known protein phosphatases in @entity375 to identify one whose loss of function alters the cellular distribution of COPII coat subunits. This screen identifies the PP2A-like phosphatase Sit4p as a regulator of COPII coat dephosphorylation. @entity8038 subunits accumulate in the sit4/\ mutant in vivo. In vitro, Sit4p dephosphorylates COPII coat subunits. Consistent with a role in coat recycling, Sit4p and its @entity1 orthologue, @entity46727 , regulate traffic from the ER to the Golgi complex.

title: Sit4p/ XXXX regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity8038 :: ('MESH:D058456', 'Disease') :: ['Hyperphosphorylated coat']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

answer: @entity46727 :: (5537,Gene) :: ['PP6']