abstract: A computational model was developed for the responses of @entity4365 ( @entity2167 ) fibers in cat. The goal was to produce realistic temporal response properties and average discharge rates in response to simple and complex stimuli. Temporal and average-rate properties of @entity2167 responses change as a function of sound-pressure level due to nonlinearities in the auditory periphery. The input stage of the @entity2167 model is a narrow-band filter that simulates the mechanical tuning of the basilar membrane. The parameters of this filter vary continuously as a function of stimulus level via a feedback mechanism, simulating the compressive nonlinearity associated with the mechanics of the basilar membrane. A memoryless, saturating nonlinearity and two low-pass filters simulate transduction and membrane properties of the inner hair cell (IHC). A diffusion model for the IHC- @entity2167 synapse introduces adaptation. Finally, a nonhomogeneous Poisson process, modified by absolute and relative refractoriness, provides the output discharge times. Responses to several different stimuli are presented. These responses illustrate nonlinear temporal response properties that cannot be achieved with linear models for @entity2167 fibers.

title: A model for the responses of XXXX fibers in cat.

entities_list: @entity4365 :: ('MESH:C565121', 'Disease') :: ['low-frequency auditory-nerve']

answer: @entity4365 :: (MESH:C565121,Disease) :: ['low-frequency auditory-nerve']


abstract: @entity1252 (referred to below as @entity1252 ) is a disorder associated with formation of immune complexes in the circulatory system and their deposition in the internal organs, as well as in the skin. The disease can appear at any age, but the vast majority of cases are @entity1 between 15 and 40 years of age. The paper presents the case of a thirty-year-old @entity1 with @entity1252 . She was admitted to hospital because of erythematous and @entity548 in the skin of her face, hands and feet and febrile states. @entity1252 was diagnosed in the @entity1 on the basis of criteria established by the American Rheumatological Association. The following abnormalities were observed in the @entity1 : @entity272 of erythematous type on the face, @entity56 to UV light, erosions of the mucous membranes of the oral cavity, changes in the kidneys confirmed by biopsy, @entity1109 , @entity1200 . Additional criteria to establish the diagnosis included: febrile states. Raynaud's sign, hair loss, presence of immunoglobulin complexes in the skin, decreased complement level. The paper discusses modern therapy of @entity1252 , based on corticosteroids and immunosuppressants. The interactions of these drugs were observed in the @entity1 . The @entity1 was treated with combined corticosteroid and cytostatic therapy, which led to the remission of the pathologic process confirmed by the clinical condition of the @entity1 and laboratory tests.

title: Favourable interactions of cytostatic and steroid drugs in treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic lesions']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['haematological symptoms']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'visceral lupus erythematosus', 'Systemic lupus erythematosus']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune disorders']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']


abstract: An open angiography-based, dose rate escalation study on the effect of intravenous infusion of recombinant tissue plasminogen activator (rt-PA) on cerebral arterial recanalization in @entity1 with acute focal @entity2806 was performed at 16 centers. @entity432 consistent with acute @entity63 in the carotid or vertebrobasilar territory in the absence of detectable @entity1779 were prerequisites for treatment. After the 60-minute rt-PA infusion, arterial perfusion was assessed by repeat angiography and computed tomography scans were performed at 24 hours to assess hemorrhagic transformation. Of 139 @entity1 with symptoms of focal @entity63 , 80.6% (112) had complete occlusion of the primary vessel at a mean of 5.4 +/- 1.7 hours after symptom onset. No dose rate response of cerebral arterial recanalization was observed in 93 @entity1 who completed the rt-PA infusion. @entity2500 were more likely to undergo recanalization by 60 minutes than were internal carotid artery occlusions. @entity385 occurred in 20.2% and parenchymatous @entity1410 in 10.6% of @entity1 over all dose rates, while neurological worsening accompanied hemorrhagic transformation ( @entity385 and parenchymatous @entity1410 ) in 9.6% of @entity1 . All findings were within prospective safety guidelines. No dose rate correlation with @entity385 , parenchymatous @entity1410 , or both was seen. Hemorrhagic transformation occurred significantly more frequently in @entity1 receiving treatment at least 6 hours after symptom onset. No relationship between hemorrhagic transformation and recanalization was observed. This study indicates that site of occlusion, time to recanalization, and time to treatment are important variables in @entity64 with this agent.

title: Recombinant tissue plasminogen activator in acute thrombotic and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['acute stroke intervention']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['Middle cerebral artery division (M2) and branch (M3) occlusions']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['Arterial occlusions']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['hemorrhagic infarction', 'Hemorrhagic infarction']

answer: @entity64 :: (MESH:D020521,Disease) :: ['embolic stroke']


abstract: OBJECTIVE: The aim of this study is to evaluate the results of radical surgery in @entity1 with stage @entity3847 to IIA2 @entity5 who were operated on at our center between 2002 and 2015. MATERIALS AND METHODS: Forty-seven cases of @entity1 with stage @entity3847 /IIA2 @entity5 who underwent primary radical surgery between 2002 and 2015 were enrolled in this study. @entity1 ' files and pathological reports were retrospectively reviewed. Surgical, pathological, and clinical variables were analyzed and their impact on survival period was researched. Disease-free survival and overall survival periods were determined using the Kaplan-Meier test. The P value was considered significant if less than 0.05. RESULTS: Type C2 radical hysterectomy with lymphadenectomy (5 pelvic, 42 pelvic and para-aortic) was performed for all of the 47 @entity1 in accordance with the Querleu-Morrow classification. Thirty-three of the cases were stage @entity3847 and 14 cases were IIa2. Five years of overall survival was 80%. Recurrence was noted in 10 (7 pelvic, 3 extrapelvic) @entity1 . Adjuvant therapies were needed for 83% of the @entity1 . A univariate analysis was made for all included variables in this research and, other than recurrence, none of them was found to be statistically significant on @entity3012 and DFS. CONCLUSIONS: Although adjuvant therapies are often resorted to, primary radical surgery is also a reasonable treatment option for stage @entity3847 /IIA2 @entity5 , especially in young premenopausal @entity1 when preserving ovarian functions is desired.

title: A Single-Institution Radical Surgery Results in Stage @entity3847 /IIA2 (Bulky) Cervical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: @entity5617 is a tragedy for mother, family, and obstetrician. Recent reviews of @entity5617 indicate that nearly half occur in pregnancies that are not candidates for traditional antepartum testing. We conducted a prospective evaluation of the effectiveness of a fetal movement screening program in reducing the fetal mortality rate. During a 7-month control period, 2519 deliveries occurred, no formal fetal movement assessment was done, and the fetal mortality rate was 8.7 per 1000 births. A pilot study was conducted to validate a protocol in which the @entity1 was instructed to record the elapsed time required to appreciate 10 fetal movements. The mean time interval was 20.9 +/- 18.1 minutes (mean +/- SD). @entity1 in whom 2 hours elapsed without 10 fetal movements (mean +/- 5 SD) were to report to the delivery unit for further evaluation. During the study period, 1864 @entity1 were delivered of @entity1 and the fetal mortality rate was 2.1 per 1000 (chi 2 = 6.8, p less than 0.01). During the study period the number of antepartum tests performed increased by 13%. Interventions for fetal compromise prompted by inadequate fetal activity tripled in the study period, resulting in a drop in fetal mortality among @entity1 with decreased movement from 44 to 10 per 1000. We conclude that the count-to-10 fetal movement screening program is simple and effective in reducing the fetal mortality rate.

title: A prospective evaluation of fetal movement screening to reduce the incidence of antepartum XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'infants']

entities_list: @entity5617 :: ('MESH:D005313', 'Disease') :: ['Fetal death', 'fetal death']

answer: @entity5617 :: (MESH:D005313,Disease) :: ['fetal death']


abstract: 1. Experiments were performed to examine the effect of inflammatory cytokines, @entity5041 ( @entity5041 ), @entity568 and IL-8, on the contractility of @entity35 aorta. 2. Pretreatment of the endothelium-denuded aortic ring with @entity568 for 3 h caused a significant inhibition of its contraction (58.9 +/- 7.8%, n = 9, P < 0.01) when induced by 10(-6) mol/L @entity2647 . 3. On the other hand, @entity5041 and IL-8 failed to show significant effects on the contractility of the aorta. 4. This inhibitory effect of @entity568 on @entity2647 -induced contraction showed dose-dependency, and completely disappeared in the presence of 10(-5) mol/L @entity3352 . 5. In cultured @entity35 vascular smooth muscle cells (VSMC), the release of @entity9077 into the extracellular medium was significantly increased by exposure to @entity568 , but not by exposure to @entity5041 or IL-8. 6. @entity5041 , @entity568 and IL-8 showed no effects on the release of @entity3542 , a stable metabolite of @entity842 (NO), from VSMC. 7. These results indicate that @entity568 , not @entity5041 or IL-8, is a potent inhibitor of the alpha-adrenergic-stimulated contraction of vascular smooth muscle and its action is mediated by the increased synthesis of @entity4770 rather than NO.

title: Inflammatory cytokines and XXXX vascular tone.

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity4770 :: ('MESH:D011464', 'Chemical') :: ['prostacyclin']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']

entities_list: @entity9077 :: ('MESH:D015121', 'Chemical') :: ['6-keto-prostaglandin F1alpha']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: PURPOSE: To elucidate the @entity227 ( @entity227 ) characteristics of normal-tension @entity726 (NTG) @entity1 with either @entity5433 or abnormal peripheral microcirculation. DESIGN: Prospective, observational study. METHODS: @entity1 : Sixty NTG @entity1 . procedures: All subjects underwent a complete ophthalmic examination and were then referred to a rheumatology department, where they were subjected to heart rate variability (HRV) assessment and nailfold capillaroscopy. Subjects with @entity227 clusters confined to the central 10 degrees or outside the central 10 degrees (defined as peripheral) in 1 hemifield were selected (n = 60). The central and peripheral regions were divided further into superior and inferior sectors. @entity1 were classified into low, middle, and high HRV groups using HRV assessment or normal and abnormal capillaroscopy groups using nailfold capillaroscopy findings. The @entity227 characteristics of the groups were compared. main outcome measures: Location of the @entity227 , depth of the @entity227 , mean deviation, and the pattern standard deviation of the @entity227 . RESULTS: The @entity227 was more frequent and deepest in the superior central sector in both the low HRV and abnormal capillaroscopy groups. The mean deviation was similar between groups, but the pattern standard deviation was significantly higher in eyes with central defects than in eyes with @entity1897 among those in the low HRV group or abnormal capillaroscopy group. Logistic regression analysis revealed that the group classified by the HRV assessment and the presence of abnormalities in the capillaroscopy were related to the location of the @entity227 . CONCLUSIONS: NTG @entity1 with @entity258 variability or abnormal nail capillaroscopy may present as central @entity227 . Therefore, vascular risk factors need to be considered when NTG @entity1 have central @entity227 .

title: Visual field characteristics in normal-tension @entity726 @entity1 with XXXX and abnormal peripheral microcirculation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['VF defects', 'visual field', 'VF defect', 'VF']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral defects']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low heart rate']

answer: @entity5433 :: (MESH:C563939,Disease) :: ['autonomic dysfunction']


abstract: BACKGROUND: The high-cure rates of 90% in @entity995 are not replicated in developing countries due to late presentation and poor compliance to treatment. The present study takes a closer look at causes of abandonment of therapy and effectiveness of counselling in reducing abandonment. PROCEDURE: A retrospective study of @entity1 with @entity995 registered at our centre from March 2008 through August 2011. RESULTS: Fifty (49.50%) of 101 @entity1 registered for treatment abandoned therapy. Abandonment rates were significantly higher in rural as compared to urban @entity1 (P   =   0.02). There was no significant difference in rate of abandonment between stages or laterality of disease and other socio-demographic factors. Telephone calls were more effective than letters in tracing @entity1 (31.2% vs. 2.4%). Major reasons cited behind abandonment were financial problems (30%) and unwillingness to enucleate (20%). Of the 12 @entity1 who returned and were retreated 6 (50%) died of progressive disease. Nineteen (73%) of those who did not return died at home. Abandonment rates steadily declined from 71.42% in 2008 to 16.66% in 2011 (P   =   0.01) due to effective pre-abandonment counselling by a support team under the National @entity995 Registry of India from 2009. CONCLUSIONS: Abandonment rates for @entity1 with @entity995 continue to be unacceptably high. Rural background, financial constraints and hesitancy to enucleate were important causes behind abandonment. Outcome of @entity1 who abandoned treatment was uniformly dismal. Inclusion of support team and intensified initial counselling helped in improving compliance.

title: Causes, outcome and prevention of abandonment in XXXX in India.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'children']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma', 'Retinoblastoma']

answer: @entity995 :: (MESH:D012175,Disease) :: ['retinoblastoma']


abstract: BACKGROUND: Malignant @entity43 (MOGCTs) are usually detected at an early stage, with @entity1 achieving a satisfactory prognosis. However, the role of staging surgery in the treatment of apparent early-stage MOGCTs remains controversial. AIMS: To investigate the role of staging procedures in apparent early-stage @entity1 . MATERIALS AND METHODS: We performed a retrospective review of 102 @entity1 who were diagnosed with MOGCTs and had malignant lesions confined to their ovaries, between January 1997 and October 2014 at the OB/GYN Hospital of Fudan University, Shanghai, China. Statistical analysis was carried out using SPSS software which included survival analysis by Kaplan-Meier method and @entity16043 's exact test. RESULTS: Three @entity1 relapsed and one died. The five-year overall survival rate and disease-free survival rate were 98.7% and 96.4%, respectively. Eighty-nine @entity1 (87.3%) received adjuvant chemotherapy, and only 23 @entity1 (22.5%) were completely staged. In total, 3/49 (6.1%), 1/44 (2.3%) and 0/49 (0.0%) @entity1 were diagnosed with malignant cells in peritoneal fluid, pelvic lymph nodes and omentum, respectively. Positive @entity5 cells were not correlated with recurrence. Univariate analysis revealed that neither complete staging surgery nor individual factors were useful prognostic factors for disease-free survival. CONCLUSIONS: The staging surgery could be omitted for apparent early-stage @entity1 affected by MOGCTs without adverse impact upon survival.

title: The role of staging surgery in the treatment of apparent early-stage malignant XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian germ cell tumours']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian germ cell tumours']


abstract: Antifibrinolytic drugs are widely used to reduce @entity190 during surgery. One serious adverse effect of these drugs is convulsive @entity410 ; however, the mechanisms underlying such @entity410 remain poorly understood. The antifibrinolytic drugs @entity927 ( @entity928 ) and   - @entity7115 ( @entity930 ) are structurally similar to the inhibitory neurotransmitter @entity2228 . Since reduced function of @entity2228 receptors causes @entity410 , we hypothesized that @entity928 and @entity930 inhibit the activity of @entity2228 receptors. Here we demonstrate that @entity928 and @entity930 are competitive antagonists of @entity2228 receptors in @entity19 . We also showed that the general anesthetic @entity5161 , and to a lesser extent @entity1875 , reverses @entity928 inhibition of @entity2228 receptor-mediated current, suggesting that these drugs could potentially be used to treat @entity928 -induced @entity410 . Finally, we measured the concentration of @entity928 in the cerebrospinal fluid (CSF) of @entity1 undergoing major cardiovascular surgery. Surprisingly, peak @entity928 concentration in the CSF occurred after termination of drug infusion and in one @entity1 coincided with the onset of @entity410 . Collectively, these results show that concentrations of @entity928 equivalent to those measured in the CSF of @entity1 inhibited @entity2228 receptors. Furthermore, @entity5161 or @entity1875 may prevent or reverse @entity928 -induced @entity410 .

title: @entity927 concentrations associated with XXXX @entity410 inhibit @entity2228 receptors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity7115 :: ('MESH:D000614', 'Chemical') :: ['aminocaproic acid']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid']

entities_list: @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity1082 is known to be the major pathogen of cervical @entity5 . Here, we report the efficacy of a bivalent @entity1799 and 18 DNA vaccine system following repeated dosing in @entity19 and @entity1707 using a recombinant baculovirus bearing @entity1 endogenous retrovirus envelope protein (AcHERV) as a vector. The intramuscular administration of AcHERV-based @entity1799 L1 and HPV18L1 DNA vaccines induced antigen-specific serum IgG, vaginal IgA, and neutralizing antibodies to levels comparable to those achieved using the commercially marketed vaccine Cervarix. Similar to Cervarix, AcHERV-based bivalent vaccinations completely blocked subsequent vaginal challenge with HPV type-specific pseudovirions. However, AcHERV-based bivalent vaccinations induced significantly higher cell-mediated immune responses than Cervarix, promoting 4.5- ( @entity1799 L1) and 3.9-(HPV18L1) fold higher interferon-y production in splenocytes upon stimulation with antigen type-specific pseudovirions. Repeated dosing did not affect the immunogenicity of AcHERV DNA vaccines. Three sequential immunizations with AcHERV-HP18L1 DNA vaccine followed by three repeated dosing with AcHERV-HP16L1 over 11 weeks induced an initial production of anti-HPV18L1 antibody followed by subsequent induction of anti-HPV16L1 antibody. Finally, AcHERV-based bivalent DNA vaccination induced antigen-specific serum IgG immune responses in @entity1707 . These results support the further development of AcHERV as a bivalent @entity1082 DNA vaccine system for use in preventing the @entity1800 as well as treating the infected @entity1 by inducing both humoral and cell-mediated immune responses. Moreover, the possibility of repeated dosing indicates the utility of AcHERV system for reusable vectors of other viral pathogen vaccines.

title: Immunogenicity of bivalent @entity1082 DNA vaccine using @entity1 endogenous retrovirus envelope-coated baculoviral vectors in XXXX and @entity1707 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

entities_list: @entity1799 :: ('333760', 'Species') :: ['HPV16', 'human papillomavirus type 16']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus', 'Human papillomavirus']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: @entity599 mustard (SM) is a strong toxic agent that causes acute and chronic health effects on a myriad of organs following exposure. Although the primary targets of inhaled @entity5745 are the epithelia of the upper respiratory tract, the lower respiratory tract is the focus of the current study, and upper tract complications remain obscure. To our knowledge there is no study addressing the secretory IgA (S-IgA), @entity2242 , @entity6417 ( @entity6417 ) in the saliva of SM-exposed victims. In this study, as many as 500 volunteers, including 372 SM-exposed cases and 128 control volunteers were recruited. A 3 ml sample of saliva was collected from each volunteer, and the level of secretory IgA, @entity2242 , and @entity6417 in the samples were compared between the two groups. The SM-exposed group showed a significantly higher amount of salivary @entity6417 and secretary IgA compared to the control group (p<.006 and p<.018 respectively). The two groups showed no significant difference (p=0.192) in the level of @entity2242 . The results also showed that the level of salivary @entity6417 is more than that of IgA in severely injured cases. The findings presented here provide valuable insight for both researchers and practitioners dealing with victims of the chemical warfare agent, @entity599 mustard. This research indicates that certain branches of the inflammatory processes mandate serious attention in therapeutic interventions.

title: Salivary levels of secretary IgA, XXXX in @entity599 mustard exposed patients 20 years after the exposure, Sardasht-Iran Cohort Study (SICS).

entities_list: @entity599 :: ('MESH:D013455', 'Chemical') :: ['sulfur', 'Sulfur']

entities_list: @entity6417 :: ('5265', 'Gene') :: ['A1AT', 'alpha 1 antitrypsin']

entities_list: @entity5745 :: ('MESH:D011007', 'Disease') :: ['mustard gas']

answer: @entity2242 :: (728,Gene) :: ['C5a and alpha 1-antitrypsin']


abstract: @entity41342 (PD) is a purified @entity41343 of @entity9052 @entity3857 , which exhibits anticancer activity. @entity3089 ( @entity3090 ), a major @entity12919 in green tea, is a strong botanical antioxidant. In this study, we investigated the possible synergistic anticancer effects of PD and @entity3090 on @entity1 @entity14 cells and explored the potential role of apoptosis in the synergistic activities. Effects of selected compounds on HCT-116 and SW-480 @entity1 @entity14 cells were evaluated by a modified trichrome stain cell proliferation analysis. Cell cycle distribution and apoptotic effects were analyzed by flow cytometry after staining with PI/RNase or @entity4404 /PI. Cell growth was suppressed after treatment with PD (10 and 20     m) for 48   h. When PD (10 and 20     m) was combined with @entity3090 (10, 20, and 30     m), significantly enhanced antiproliferative effects were observed in both cell lines. Combining 20     m of PD with 20 and 30     m of @entity3090 significantly decreased S-phase fractions of cells. In the apoptotic assay, the combination of PD and @entity3090 significantly increased the percentage of apoptotic cells compared with PD alone (p   <   0.01). The synergistic apoptotic effects were also supported by docking analysis, which demonstrated that PD and @entity3090 bound in two different sites of the @entity4404 protein. Data from this study suggested that apoptosis might play an important role in the @entity3090 -enhanced antiproliferative effects of PD on @entity1 @entity14 cells.

title: The synergistic apoptotic interaction of @entity41342 and XXXX in @entity1 @entity14 cells.

entities_list: @entity3857 :: ('MESH:D012503', 'Chemical') :: ['saponins']

entities_list: @entity41343 :: ('CHEBI:26606', 'Chemical') :: ['sapogenin']

entities_list: @entity3089 :: ('MESH:C045651', 'Chemical') :: ['Epigallocatechin gallate']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity41342 :: ('MESH:C004564', 'Chemical') :: ['Panaxadiol']

answer: @entity3089 :: (MESH:C045651,Chemical) :: ['epigallocatechin gallate']


abstract: UNASSIGNED: The source of continued @entity158 following fixation of traumatic femoral shaft @entity174 is not always clear. Intra-articular hip pathology is often overlooked when evaluating the etiology of @entity158 . The purpose of this study was to describe cases of intra-articular hip pathology following traumatic femoral shaft @entity174 . This was a retrospective case series of @entity1 presenting to a private practice orthopedic clinic from 2012 to 2015. Three @entity1 presented with symptomatic intra-articular hip pathology following traumatic ipsilateral femoral shaft @entity174 . @entity1 who underwent hip arthroscopy with allograft labral reconstruction were identified retrospectively. Validated, subjective outcome scores administered included the Modified Harris Hip Score (MHHS), Lower Extremity Functional Scale (LEFS), visual analog scale (VAS) for @entity158 , and VAS scale for @entity1 satisfaction. Three @entity1 were identified with residual, disabling @entity158 after femoral shaft @entity174 fixation following a traumatic motor vehicle accident. All 3 @entity1 were found to have a symptomatic ipsilateral labral tear. In 2 of the @entity1 , an indentation on the lateral femoral head was appreciated, which was hypothesized to be caused by a subluxation event. All 3 @entity1 were treated with arthroscopic hip surgery. At final follow-up, all 3 @entity1 showed significant improvement in MHHS, VAS @entity158 scores, level of satisfaction, and LEFS. Residual @entity158 following ipsilateral femoral shaft @entity174 is not always related to implant. Intra-articular hip pathology should be considered in @entity1 with lingering @entity158 . [Orthopedics. 2016; 39(6):e1080-e1084.].

title: Hip XXXX After a Femoral @entity174 : It Is Not Always Related to the Implant.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['residual pain', 'hip pain', 'pain', 'groin pain']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: BACKGROUND: The first set of aims of the present study was to determine the prevalence of @entity1314 ( @entity1314 ) in a nation, and gender differences in the types and numbers of @entity1314 endorsed. The second set of aims was to establish the relationship of @entity1726 to other, @entity74 , physical conditions, and disability. METHOD: Data were obtained from the Australian National Survey of Mental Health and Wellbeing, conducted between May and August 1997. A stratified random sample of households was generated, from which all those aged 18 or over were considered potential interviewees. There were 10,641 respondents to the survey, and this represented a response rate of 78%. Each interviewee was asked 59 questions indexing specific ICD-10 @entity1726 criteria. RESULTS: Of the total survey sample, 704 @entity1 had at least one @entity1726 . Using weighted replicate weights, it was estimated that approximately 6.5% of the adult population of Australia have one or more @entity1314 (lifetime prevalence). @entity1 with @entity1726 were more likely to be younger, male, and not married, and to have an @entity148 , an @entity1316 , a substance use disorder, or a physical condition. They were also more likely to have greater disability than those without @entity1726 . CONCLUSION: The study is the first nationwide survey of @entity146 conducted within Australia. It provides an estimate of the prevalence of the various types of @entity1726 . The survey has considerable limitations, however, and these are discussed.

title: XXXX in the community: a report from the Australian National Survey of Mental Health and Wellbeing.

entities_list: @entity1 :: ('9606', 'Species') :: ['Persons', 'persons']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorder']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorder']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['non-PD disorders']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['PDs', 'personality disorders']

answer: @entity1314 :: (MESH:D010554,Disease) :: ['Personality disorders']


abstract: In 1989, the French @entity1485 -METRA Group ( @entity1485 -METRA = Prevention Cardio-Vasculaire en M  decine du Travail) started a large prospective survey of cardiovascular ( @entity31338 ) morbidity and mortality and of CVD risk factors, especially @entity165 , in a working population in Ile-de-France, a region including Paris. This report presents the first results of this study, based on a sample of 5758 @entity1 and 2603 @entity1 , aged 18-65 years. The variables examined included the levels of total @entity165 1/2 (TC), High-density-lipoprotein @entity165 (HDL-C), low-density-lipoprotein @entity165 (LDL-C), and the other major CVD risk factors (smoking, sedentary way of life, @entity101 , @entity1007 , use of oral contraceptives and familial history of CVD risks). TC and LDL-C significantly increased with age. The changes with age were significantly different in @entity1 and @entity1 . The levels were similar in both sexes at less than 30 yrs, increased sharply for @entity1 after age 30 and were significantly higher in @entity1 than in @entity1 from 30 to 55 yrs. Beyond 55 yrs, no difference was observed between the two sexes. In contrast, HDL-C was higher in @entity1 at all age ranges. In the total sample, 35% of @entity1 and 21% of @entity1 were @entity753 (TC > or = 2.4 g/L). Our observations fully confirm and refine previous findings in the US and in other European countries. In addition, a substantial set of data on CVD risk factors for the working population in France, especially for female subjects for whom data are scanty, is now available.

title: @entity165 and other cardiovascular risk factors in a working population in Ile-de-France (France): first results of the XXXX -METRA study.

entities_list: @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1485 :: (158372,Species) :: ['PCV']


abstract: Studies conducted in real Space and in ground-based @entity262 ( @entity262 ) have demonstrated changes in numerous lymphocyte functions. In this investigation we explored whether the observed functional changes in lymphocytes in @entity262 are associated with changes in gene expression. NASA-developed Rotating Wall Vessel (RWV) bioreactor was utilized as a @entity262 . Activated T lymphocytes were obtained by adding 100 ng/ml of anti-CD3 and 100 U/ml of @entity1199 in RPMI medium to blood donor mononuclear cells for 4 days. After that the cells were washed and additionally cultured for up to 2 weeks with media (RPMI, 10% FBS and 100 U/ml @entity1199 ) replacement every 3-4 days. Flow cytometry analysis had proven that activated T lymphocytes were the only cells remaining in culture by that time. They were split into two portions, cultured for additional 24 h in either static or simulated microgravity conditions, and used for RNA extraction. The gene expression was assessed by Affymetrix GeneChip @entity1 U133A array allowing screening for expression of 18,400 genes. About 4-8% of tested genes responded to MG by more than a 1.5-fold change in expression; however, reproducible changes were observed only in 89 genes. Ten of these genes were upregulated and 79 were downregulated. These genes were categorized by associated pathways and viewed graphically through histogram analysis. Separate histograms of each pathway were then constructed representing individual gene expression fold changes. Possible functional consequences of the identified reproducible gene expression changes are discussed.

title: Gene expression alterations in activated XXXX T-cells induced by modeled microgravity.

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['MAS', 'microgravity analog systems']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To evaluate the influence of marital status on sporadic @entity5513 ( @entity5513 ) in the United States. STUDY DESIGN: Analysis of the Surveillance, Epidemiology, and End Results (SEER) database. SETTING: National, population-based @entity5 registry. SUBJECTS AND METHODS: The SEER database was queried to identify all @entity1 with sporadic @entity5513 between 2004 and 2012. Univariable and multivariable analyses were used to identify differences in @entity5 size at presentation, management strategy, and mortality on the basis of @entity1 marital status. RESULTS: Eight thousand and eight hundred thirty eight @entity1 met inclusion criteria. When comparing @entity1 groups on the basis of marital status, significant differences emerged. Univariable and multivariable analyses revealed that married subjects were older, had smaller @entity5 at presentation, and had better overall survival compared with non-married @entity1 . After adjusting for baseline differences between groups, non-married subjects were more likely to undergo observation (odds ratio [OR] 1.2, 95% confidence interval [CI] 1.08-1.35, p=0.009), and were less likely to undergo surgery (OR 0.85, 95% CI 0.76-0.94, p=0.002) than married subjects, while there was no difference between groups with regard to radiation treatment (OR 0.99, 95% CI 0.88-1.11, p=0.828). Individual differences between non-married subgroups (i.e., single, separated/divorced, and widowed) are also reported. CONCLUSION: Marital status influences disease presentation, treatment, and outcome in @entity1 with sporadic @entity5513 in the United States. The authors speculate that greater social support of married subjects may drive many of these differences between groups. Future research is needed to further elucidate the underlying causes for these findings as well as the influence of other important demographic variables such as socioeconomic status and general health status.

title: Influence of Marital Status on XXXX in the United States.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5513 :: ('MESH:D009464', 'Disease') :: ['VS', 'vestibular schwannoma']

answer: @entity5513 :: (MESH:D009464,Disease) :: ['Vestibular Schwannoma']


abstract: PURPOSE: To compare the potentials of @entity11830 (Endoren) to those of @entity2287 with the dynamic contrast-enhanced technique in the differential diagnosis of focal @entity409 . MATERIAL AND METHODS: Forty @entity1 with at least one focal liver lesion diagnosed at US underwent MRI. We used a 1.5 T unit and employed single-shot half-Fourier T2-weighted FSE and spoiled gradient-echo T1-weighted sequences before and after @entity2287 injection. Multiple acquisitions were obtained during the arterial, portal and delayed phases. Twenty-four to 48 hours later T2*-weighted GRE and SPGR/90 degrees sequences were obtained after @entity11830 administration. In the characterization of solid lesions the gold standard was biopsy performed with a shearing needle; for the diagnosis of @entity2695 and of 11 metastatic lesions we considered follow-up and clinical data as important diagnostic elements. RESULTS: We found 12 hepatocarcinomas, 14 @entity3 , 4 cases of @entity4383 ( @entity4383 ), 4 @entity652 and 6 @entity2695 . The diagnosis was correct and confirmed by the conventional examination in all cases but 2 @entity1412 and 2 @entity2695 . Precontrast studies showed slight hyperintensity in 2 of 4 cases of @entity4383 , while the other 2 lesions appeared isointense and were therefore detected only on postcontrast images, where there was contrast agent uptake during the arterial phase and rapid washout. We found only one central scar hyperintense on T2- and hypointense on T1-weighted images. After @entity11830 administration all lesions appeared isointense to surrounding parenchyma on T2* GRE sequences. @entity652 were isointense in the precontrast phase and postcontrast 3 of them showed strong @entity2287 uptake and rapid washout. After @entity11830 two of the 4 lesions were hyperintense while the other two were isointense to the parenchyma. Four of 6 @entity2695 exhibited a typical pattern characterized by signal hyperintensity on T2-weighted sequences and on @entity11830 -enhanced T1- and T2-weighted sequences. Two @entity2695 were supposed to be of malignant nature but histology showed the presence of a strong fibrotic component. Hepatocarcinomas could be detected on precontrast images. After @entity2287 administration 10 lesions appeared hyperintense in the arterial phase and 2 were hypointense. After @entity11830 all lesions exhibited homogeneous signal hyperintensity and appeared slightly bigger than on @entity2287 -enhanced images. The @entity3 were only partly demonstrated by MRI. Postgadolinium studies showed 13 lesions with hyperintense signal in the portal phase. @entity11830 administration detected 14 lesions that appeared slightly bigger than on @entity2287 -enhanced images. CONCLUSIONS: @entity11830 can help also in characterizing primary lesions with an atypical signal pattern after contrast agent administration thanks to its intrinsic capability of accumulating in benign lesions. However it remains difficult to characterize well differentiated hepatocarcinomas and @entity652 . Finally, @entity11830 improves MR capabilities in detecting secondary lesions and possible satellite nodules.

title: [Magnetic resonance imaging of hepatic focal lesions: dynamic contrastographic evaluation with XXXX versus reticulo-endothelial hepato-specific contrast media].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver lesions']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['adenomatous lesions']

entities_list: @entity4383 :: ('MESH:D020518', 'Disease') :: ['FNH', 'focal nodular hyperplasia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'Adenomas']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['Gadolinium']

answer: @entity2287 :: (MESH:D005682,Chemical) :: ['gadolinium']


abstract: OBJECTIVE: Reduction of @entity954 is desirable to improve intraoperative visibility and to avoid complications. STUDY DESIGN: Prospective, controlled, randomized, double-blinded study. SETTING: Inclusion criteria were chronic rhinosinusitis with @entity480 that involved all paranasal sinuses, Lund-CT score > or =12, and double-blind preoperative randomization of narcotics. Exclusion criteria included @entity854 , perioperative blood pressure outside the range of 70 to 140 mmHg systolic and 50 to 90 mmHg diastolic and perioperative medication. @entity190 (mL), @entity190 per minute (mL/min), platelet function, and parameter for endoscopic vision were evaluated. RESULTS: Forty-six @entity1 (22 sedated with @entity2614 / @entity3575 , 24 sedated with @entity1875 / @entity3575 ) completed the study. @entity190 (300.1 +/- 168.5 mL/276.9 +/- 201.3 mL), @entity190 per minute, and endoscopic vision showed no group difference. Platelet function was significantly impaired 45 minutes after onset of surgery in both groups, but more pronounced after @entity1875 anesthesia. CONCLUSION: Under conditions of balanced circulatory parameter, equal @entity190 and endoscopic vision can be achieved with both tested anesthetic regimens. During extended operations demonstrated thrombocyte impairment by @entity1875 may become clinically relevant.

title: @entity1875 versus XXXX : bleeding in endoscopic sinus surgery.

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['Total blood loss', 'blood loss']

entities_list: @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormal coagulation']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['intraoperative bleeding']

entities_list: @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity2614 :: (MESH:C009250,Chemical) :: ['sevoflurane']


abstract: BACKGROUND AND OBJECTIVE: The polymorphism of the @entity13490 gene ( @entity13490 / @entity13490 ) has been associated with metabolic alterations. In this study the association between the 3'UTR @entity39508 polymorphism and @entity209 components was evaluated. SUBJECTS AND METHODS: The population (n=218) was distributed in 3 groups: the control group with no metabolic alterations (n=77), nSMA group with isolated metabolic alterations (n=94) and @entity15 group with @entity209 (n=47). The 3'UTR @entity39508 polymorphism was analyzed by PCR-RFLP. RESULTS: Central @entity28 was the most frequent alteration in both nSMA (56.4%) and @entity15 (91.5%) groups followed by low @entity6599 levels in the nSMA group (42.6%) and arterial @entity101 in the @entity15 group (85%). The frequency of the @entity39508 genotype was 20.2% in the population. The G/A genotype was more frequently found in the @entity15 (38.3%) and nSMA (17%) groups than in the control group (13%). The allelic distribution between the control group (+62G=0.94, +62A=0.06) and @entity15 group (+62G=0.81, +62A=0.19) was significantly different (P=.0001). Significant associations between the G/A genotype and high values of abdominal circumference (P=.047), basal glycemia (P=.02) and systolic arterial pressure (P=.003) were found. CONCLUSION: The findings suggest the association between the G/A genotype and high values of systolic arterial pressure, basal glycemia and abdominal circumference. This association was independent of the @entity209 context.

title: [3'UTR @entity39508 polymorphism of the XXXX gene coding @entity13490 and its association with @entity209 components].

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

answer: @entity13490 :: (56729,Gene) :: ['RETN']


abstract: Sixty-three @entity1 with @entity978 , in stages I or II, asymptomatic (A) or symptomatic (B), were diagnosed and followed at the Chaim Sheba Medical Center from 1969 to 1976. Only 14 were staged pathologically. Until 1971, the @entity1 received mantle or "inverted Y" therapy only; thereafter, an extended field that included mantle, upper abdomen and spleen irradiation was given. Symptomatic @entity1 , as well as @entity1 with extranodal involvement, received MOPP chemotherapy ( @entity1568 mustard, @entity1891 , @entity4174 and @entity229 ) after termination of radiotherapy. Of 51 @entity1 who were in stage IA or IIA, six relapsed 20 to 43 months after irradiation. Three had a pelvic recurrence; two of them were surgically staged. Thus, in only 1 of 51 @entity1 could staging laparotomy possibly have detected pelvic disease and resulted in different therapy. Our results suggest that total nodal irradiation and staging laparotomy are not mandatory in stages IA and IIA of @entity978 . The group of 12 symptomatic @entity1 is too small to allow us to draw definite conclusions as to the role of staging laparotomy and adjuvant chemotherapy. However, in view of the high relapse rate in the upstaged symptomatic @entity1 , it seems that chemotherapy should be given to these @entity1 .

title: Selective splenectomy in XXXX , stages I and II. Results of treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity4174 :: ('MESH:D011344', 'Chemical') :: ['procarbazine']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']


abstract: Reversed-phase liquid chromatography (RP-LC) and size exclusion liquid chromatography (SE-LC) methods were validated for the assessment of recombinant @entity1 @entity461 (rhPTH 1-34). The gradient RP-LC method was carried out on a Zorbax 300 SB C(18) column (150 mm   4.6 mm i.d.), maintained at 40   C. The mobile phase A consisted of 0.1 M @entity2398 buffer, pH 2.3, and the mobile phase B was @entity1626 . The SE-LC method was carried out on a BioSep-SEC-S 2000 column (300 mm   7.8 mm i.d.), maintained at 25   C. The mobile phase consisted of 0.1 M @entity8718 buffer, pH 2.5, run isocratically at a flow rate of 0.7 mL min(-1). Chromatographic separation was obtained with retention times of 12.2 min, and 13.2 min, and was linear over the concentration range of 1-250  g mL(-1) (r(2) = 0.9997) and 2-300  g mL(-1) (r(2) = 0.9993), respectively, for RP-LC and SE-LC, with photodiode array (PDA) detection at 214 nm. Specificity was established in degradation studies, which also showed that there was no interference of the excipients. Equally, the accuracy was 100.49% and 100.22%, with bias lower than 1.12% and 0.81% respectively. Moreover, the in vitro cytotoxicity test of related proteins and higher molecular weight forms showed significant differences (p < 0.05). Chromatographic methods were applied for the content/potency assessment of rhPTH and related proteins in biopharmaceutical injectable dosage forms, and the results were correlated with those of in vitro and in vivo bioassays. It is concluded that the employment of the methods in conjunction allows a great improvement in monitoring stability, contributing to evaluate alternatives which improve the quality control and thereby assure the therapeutic efficacy of the biotechnology-derived medicine.

title: Assessment of recombinant XXXX @entity461 : correlation of LC methods with bioassays.

entities_list: @entity8718 :: ('MESH:C030242', 'Chemical') :: ['phosphoric acid']

entities_list: @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile']

entities_list: @entity2398 :: ('CHEBI:32149', 'Chemical') :: ['sodium sulphate']

entities_list: @entity461 :: ('5741', 'Gene') :: ['parathyroid hormone']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: @entity6228 ( @entity6228 ) is a magnetic resonance imaging (MRI) technique in which the magnetic susceptibility characteristic of molecular and cellular components, including @entity68 and myelin, is quantified. Rapid @entity68 accumulation in subcortical nuclei and myelination of the white matter tracts are two important developmental processes that contribute to cognitive functions. Both also contribute to the magnetic susceptibility of the brain tissues. Here, we used the @entity6228 as indirect measures of @entity68 in subcortical nuclei and myelin in caudo-frontal white matter pathways. We included two groups of @entity1 ; 21 @entity1 aged 6-7years and 25 adults aged 21-40years. All subjects also performed tests estimating their visuo-spatial working memory capacity. Adults had higher magnetic susceptibility in all subcortical nuclei, compared to @entity1 . The magnetic susceptibility of these nuclei highly correlated with their previously reported @entity68 content. Moreover, working memory performance correlated significantly with the magnetic susceptibility in caudate nucleus in both @entity1 and adults, while the correlation was not significant for gray matter density. @entity6228 of white matter in the caudo-frontal tract also differed between @entity1 and adults, but did not correlate with working memory scores. These results indicate that @entity6228 is a feasible technique to measure developmental aspects of changes in the striatum, possibly related to @entity68 content that is relevant to cognition.

title: @entity6228 of striatum in XXXX and adults, and its association with working memory performance.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children']

entities_list: @entity6228 :: ('MESH:C535477', 'Disease') :: ['QSM', 'Quantitative susceptibility mapping']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: The aim of this work has been retrospective evaluation of flexion and supination strength as well as range of motion after reinsertion of biceps tendon using Boyd and Anderson method. In the years 2000-2005 this method was used in therapy of 9 @entity1 . All them had the right limb dominant. The average age of @entity1 in the moment of injury was 48 years (from 27 to 58). The observation period was 3 years and 7 months. 7 of them showed up for the check examination. One of the @entity1 a complication in the form of radioulnar syntostosis and complete loss of @entity717 . The rest of @entity1 did not exhibit the significant funcional limits of extension and flexion movement rates and @entity717 . In those six @entity1 the flexion strength and movement of supination strength were measured using dynamometer of own construction. Four @entity1 had the right limb operated, two of them had the left one. The control group constituted 30 healthy, randomly chosen, right-handed @entity1 . Statistical assessment concerning quantity was only possible for the right limbs. Statistical difference between control group and tested group as for flexion strength and moment of supination strength was not observed. Operation of early anatomic reinsertion of @entity397 using Boyd and Anderson method enables full recovery of the forearm flexion and supination strength.

title: [Results of Boyd and Anderson reconstruction of distal biceps brachii XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['forearm rotation']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured biceps tendon']

answer: @entity397 :: (MESH:D012421,Disease) :: ['tendon rupture']


abstract: UNASSIGNED: We conducted a prospective cohort study to evaluate @entity1004 ( @entity1004 ) as a risk factor for detectable plasma viral load in @entity16090 -positive female sex workers (FSWs) on antiretroviral therapy (ART) in Kenya. @entity1004 in the past year was defined as  >= 1 act of physical, @entity458 by the index partner (i.e. boyfriend/husband). The primary outcome was detectable viral load (>= 180 copies/ml). In-depth interviews and focus groups were included to contextualize results. Analyses included 195 @entity1 (570 visits). Unexpectedly, @entity1004 was associated with significantly lower risk of detectable viral load (adjusted relative risk 0.21, 95  % CI 0.05-0.84, p-value  =  0.02). Qualitative findings revealed that @entity1 valued emotional and financial support from index partners, despite @entity1004 . @entity1004 was not a major barrier to ART adherence. The observed association between @entity1004 and lower risk of detectable viral load in FSWs may be due to unmeasured personal and relationship factors, warranting further research.

title: A Prospective Study of Intimate Partner Violence as a Risk Factor for Detectable Plasma Viral Load in XXXX -Positive @entity1 Engaged in Transactional Sex in Mombasa, Kenya.

entities_list: @entity1004 :: ('MESH:C563733', 'Disease') :: ['IPV', 'intimate partner violence']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual, or emotional violence']

answer: @entity16090 :: (11709,Species) :: ['HIV']


abstract: The @entity694 ( @entity694 ) procedure creates an intestinal leakage of feces, resulting in diffuse @entity298 and @entity325 . @entity19 models of @entity694 have been used to study @entity295 experimentally. The aim of the present study was to establish @entity694 in @entity35 and to provide basic functional characteristics of this model. In analogy to the @entity19 model, 3 degrees of severity of @entity694 , 2 sublethal and 1 lethal, were established depending on the stent diameter. Radio-telemetric recordings in a sublethal model showed that the nonsurvivors remained hemodynamically stable until approximately 1 h before death, when heart rate and blood pressure fell rapidly. Intestinal microcirculatory changes were analyzed 3, 6, 12, and 18 h after @entity694 surgery using intravital microscopy in a sublethal model. After 18 h, the numbers of the leukocytes firmly adhering to the endothelium and of the ones temporarily interacting were significantly increased. The levels of @entity568 and @entity3426 increased continuously during the @entity694 experiments while remaining unchanged in the sham group. @entity1505 and @entity13358 levels of @entity694 animals reached a maximum after 12 h. In conclusion, a @entity35 model of @entity694 has been established and characterized with regard to alterations in cardiovascular and microcirculatory function as well as plasma cytokine levels. In experimental settings where genetically engineered animals are not required, it will facilitate detailed examination of dynamic changes in integrated organ function during the course of @entity295 and the investigation of treatment strategies.

title: Colon ascendens stent @entity298 --a model of XXXX adopted to the @entity35 : physiological, microcirculatory and laboratory changes.

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['polymicrobial sepsis']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon ascendens stent peritonitis', 'CASP sepsis', 'CASP']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']

answer: @entity295 :: (MESH:D018805,Disease) :: ['sepsis']


abstract: AIM: To assess clinicians' individual variables that might influence decision-making for the restoration of deep proximal @entity1547 in primary molars. METHODS: A pre-coded questionnaire that sought @entity1 ' treatment choices for a deeply carious second mandibular primary molar, as depicted in a simulated periapical radiograph, along with a specific clinical scenario, was distributed among a random sample of 157 dentists and 15 paediatric dentists. @entity1 were asked to answer questions. After combining the pulpotomy and pulpectomy treatment choices under a 'pulp therapy' category, a binary dependent variable was constructed. Logistic regression of the ratio of the @entity1 who would restore the questioned tooth by a method in question, was run. RESULTS: A total of 155 dentists (116 males and 39 females) completed the survey, giving a response rate of 90%. Of these 53% of dentists recommended pulpotomy followed by definitive restoration and 39% recommended removal of caries and restoration without pulp therapy. In the logistic regression model, males and graduates of English language undergraduate dental programs had higher probabilities of restoring without prior pulp therapy (p<0.03 and p<0.02, respectively). Compared with graduates of Asian programs, dentists who graduated from Eastern Europe and the Middle East, showed lower likelihoods of restoring the tooth without prior pulp therapy (p<0.01 and p<0.004, respectively). Dentists who treated an average of 6-16 @entity1 @entity1 during a week had a lower probability of restoring the tooth without prior pulp therapy than those who were not currently involved in treating @entity1 (p<0.01). No other measured variables were associated with @entity1 's treatment choices. CONCLUSIONS: The lack of agreement among dentists regarding their optimal treatment recommendations for deep proximal @entity1547 appears to be due mainly to inter-individual, educational, training and practice characteristic factors.

title: Restorative treatment decisions for deep proximal XXXX in primary molars.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patients', 'participant', 'Participants', 'child']

entities_list: @entity1547 :: ('MESH:D003731', 'Disease') :: ['carious lesions']

answer: @entity1547 :: (MESH:D003731,Disease) :: ['carious lesions']


abstract: AIM: The aim of this study was to assess if discrepancy between power-Doppler voiding urosonography (PD-VUS) and voiding cystourethrography (VCUG) affects the management of @entity1 with primary @entity3025 ( @entity3025 ). MATERIALS AND METHODS: Fifty-six @entity1 with suspected or known @entity3025 were assessed both by PD-VUS and VCUG. Two independent observers, both pediatric surgeons, each aware of the results of only one imaging modality, advised @entity1 's management according to present care standards. Agreement between diagnostic findings at the two imaging modalities and between therapeutic advice of the two observers was evaluated using kappa statistics. RESULTS: PD-VUS diagnosed @entity3025 in 3 @entity1 and 6 ureteral units more than VCUG. VCUG showed @entity3025 in 2 ureteral units, but in no @entity1 more than PD-VUS. Accuracy of PD-VUS compared with VCUG was 92.8% and 94.6% considering ureteral units and @entity1 , respectively. The two observers disagreed about the management of 4 (7%) of 56 cases. Agreement was significant (P < .001) both between findings at the two imaging modalities and between management options advised by the two independent observers. CONCLUSION: Vesicoureteric reflux management based on PD-VUS findings is consistent with a management based on standard VCUG.

title: Discrepancy between power-Doppler voiding urosonography and voiding cystourethrography is not relevant for the management of primary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity3025 :: ('MESH:D014718', 'Disease') :: ['vesicoureteric reflux', 'VUR']

answer: @entity3025 :: (MESH:D014718,Disease) :: ['vesicoureteric reflux']


abstract: The effects of @entity4854 and @entity3190 on @entity8 of @entity1372 , @entity460 , and @entity1391 were studied in @entity235 employing the recollection micropuncture technique. Subthreshold sustained @entity4854 resulted in an isonatric inhibition of proximal tubular @entity1372 , fluid, @entity460 , and @entity1391 reabsorption by 8-14%. Fractional excretion of @entity1372 and @entity1391 , however, fell (P is less than 0.01) indicating that the increased delivery of these ions was reabsorbed in portions of the nephron distal to the site of puncture and in addition net @entity1372 and @entity1391 transport was enhanced resulting in a significant antinatriuresis and antiphosphaturia. The creation of a steady state plateau of @entity3190 while maintaining the blood @entity413 concentration of euglycemic levels mimicked the effects of @entity4854 on proximal tubular transport and fractional excretion of @entity1372 and @entity460 . Tubular fluid to plasma @entity9959 ratio fell, similar to the @entity1602 studies. These results suggest that the effects of @entity4854 on @entity8 of @entity1372 and @entity460 may be mediated through changes in plasma @entity9959 concentration. In contrast to @entity4854 , however, @entity3190 cuased a significant fall in tubular fluid to plasma @entity1391 ratio with enhanced proximal tubular @entity1391 reabsorption (P is less than 0.02). This occurred concomitantly with a significant inhibition of proximal tubular @entity1372 transport. These data indicate that @entity9959 has a direct effect on proximal tubular @entity1391 reabsorption, and this effect of @entity9959 is masked by the presence of increased amounts of unreabsorbed @entity413 in the tubule that ensues when @entity3190 occurs secondary to @entity4854 . Fractional excretion of @entity1391 fell significantly during @entity9959 infusion but unlike the @entity1602 studies, the fall in @entity1391 excretion could be entirely accounted for by enhanced proximal reabsorption.

title: The effects of XXXX and @entity9959 on renal electrolyte transport.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal handling']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: The purpose of the study was to evaluate CT criteria for @entity3 in @entity1 with potentially resectable @entity189 of the pancreatic head, with surgical and histopathological correlation. In 113 @entity1 evaluated with spiral CT for suspected @entity788 , several CT criteria for @entity3 were scored prospectively for the @entity6315 ( @entity6315 ) and the superior mesenteric vein (SMV): length of @entity5 contact with @entity6315 /SMV (0 mm, < 5 mm, > 5 mm); circumferential involvement of the vein (0 degree, 0-90 degrees, 90-180 degrees, > 180 degrees); degree of @entity850 ; irregularity of the vessel margin; and @entity5 convexity towards vessel. 65 @entity1 underwent surgery. @entity788 was proven and pathology of the vascular margin was obtained in 50 of these @entity1 . CT findings for single and combined criteria were correlated with pathology in these 50 @entity1 , 30 of whom showed @entity1211 . Invasion was found in all cases with SMV narrowing (n = 7), @entity6315 contour involvement > 90 degrees (n = 6), @entity6315 narrowing (n = 5) and @entity6315 wall irregularity (n = 3). The vascular ingrowth rate was 88% (15/17) for @entity5 concavity towards the @entity6315 or SMV. Poor predictors of ingrowth were length of @entity5 contact with @entity6315 > 5 mm (78% ingrowth, 14/18) and contour involvement of the SMV > 90 degrees (83% ingrowth, 10/12). Absence of vascular ingrowth could not be predicted in 100%. In conclusion, CT criteria can predict a high risk of invasion in potentially resectable @entity5 . Narrowing of the SMV and the @entity6315 seems the most reliable criterion, as well as circumferential involvement of the @entity6315 > 90 degrees. The best combination of criteria was @entity5 concavity with circumferential involvement > 90 degrees (sensitivity 60% and positive predictive value 90%).

title: CT criteria for @entity3 in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic head carcinoma', 'pancreatic head carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['venous invasion']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous ingrowth']

entities_list: @entity6315 :: ('MESH:C563407', 'Disease') :: ['PV', 'portal vein']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic head carcinoma']


abstract: OBJECTIVE: The aim of this study is the prediction of specific factors associated with utilization patterns of mental health care. METHOD: Course of treatment of 272 out- @entity1 and in- @entity1 was observed for one year. @entity1 were asked five times (baseline, 1 month, 3, 6, and 12 months) about their utilization behavior. RESULTS: 71% of the @entity1 continued treatment, 6% ended treatment in agreement with their therapists, and 23% dropped out of treatment. 24 @entity1 of those who dropped out, i.e. 38% of this subgroup, returned to treatment during the one year period. Multivariate analyses indicate that continuity of treatment is associated with referrals from other institutions, male gender, the diagnosis of functional @entity716 , high subjective well-being, and poor social functioning. First-time use of the corresponding institution, in- @entity1 status, and living alone are predictors of treatment-dropout. @entity1 who ended treatment in agreement with their therapists are the best socially integrated group. Drop-outs who returned to treatment during the one year period have more unfavorable clinical premises, and are less well integrated socially than drop-outs who do not take up their treatment again. CONCLUSIONS: Therapeutic interventions, such as permanent efforts towards the maintenance of a supportive therapeutic relationship, motivate @entity146 @entity1 to keep a continuing treatment-alliance. Well functioning communication between, or rather coordination of out- @entity1 and in- @entity1 treatment increases the chance of a continuous course of treatment.

title: [Utilization of XXXX treatment. Who drops out, who comes back and who stays?].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: Purpose. Transoral robotic surgery (TORS) has increased in popularity in the management of @entity957 of the @entity135 . However, TORS does not address the neck or @entity37397 ( @entity37397 ). In the current report, we highlight the impact of the lack of adjuvant radiotherapy on @entity37397 recurrence after TORS. Materials and Methods. A 58-year-old Caucasian male presented with @entity957 of the @entity135 of unknown primary. He was offered radiotherapy as a definitive management for clinical stage T0N2aM0, stage IVA, but he opted to left neck dissection. Follow-up PET-CT scan revealed recurrence in the left base of tongue and right level II lymph node. He was offered radiotherapy which he declined and opted to TORS and right neck dissection. Follow-up PET-CT scan showed recurrence in left @entity37397 for which he underwent salvage concurrent chemoradiotherapy to 70   Gy. Results. After a followup of 9 months from the date of salvage chemoradiotherapy completion, the @entity1 is with no evidence of disease. Conclusions. TORS followed by adjuvant radiotherapy seems reasonable in the context of @entity957 of the @entity135 due to the odds of @entity37397 involvement. Further reports are warranted to optimize post-TORS adjuvant treatment.

title: Lack of adjuvant radiotherapy may increase risk of retropharyngeal node recurrence in @entity1 with @entity957 of the XXXX after transoral robotic surgery.

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity37397 :: ('MESH:D017703', 'Disease') :: ['RPN', 'retropharyngeal nodes']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck']


abstract: @entity2401 in @entity1 is often associated with an @entity792 in which @entity299 ( @entity299 ) is a major autoantigen. Experimental @entity2401 (EAM) is induced in @entity19 by immunization with @entity299 . We found that EAM in A/J @entity19 exhibits a @entity61 -like phenotype demonstrated by the histological picture of the @entity299 (eosinophils and giant cells) and by the humoral response (association of @entity6527 response with disease and up-regulation of total IgE). Blocking @entity58 with anti- @entity58 monoclonal antibody (mAb) reduced the severity of EAM. This reduction in severity was associated with a shift from a @entity61 -like to a @entity630 -like phenotype represented by a reduction in @entity299 -specific @entity6527 ; an increase in @entity299 -specific @entity9749 ; an abrogation of total IgE response; a decrease in @entity58 , @entity59 , and @entity1312 ; as well as a dramatic increase in @entity60 production in vitro. Based on the latter finding, we hypothesized that @entity60 limits disease. Indeed, @entity60 blockade with a mAb exacerbated disease. The ameliorating effect of @entity58 blockade was abrogated by co-administration of anti- @entity60 mAb. Thus, EAM represents a model of an organ-specific @entity792 associated with a @entity61 phenotype, in which @entity58 promotes the disease and @entity60 limits it. Suppression of @entity60 represents at least one of the mechanisms by which @entity58 promotes EAM.

title: Experimental @entity2401 in A/J XXXX is an @entity58 -dependent disease with a @entity61 phenotype.

entities_list: @entity60 :: ('15978(Tax:10090)', 'Gene') :: ['interferon (IFN)-gamma', 'IFN-gamma']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune process', 'autoimmune disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['CM', 'heart lesions', 'cardiac myosin']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['autoimmune myocarditis', 'Myocarditis']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: OBJECTIVE: We aimed to describe the pattern of @entity580 in an adult medical-surgical intensive care unit (ICU). METHODS: A 2-year prospective cohort study of @entity580 surveillance in a 12 - bed adult medical and surgical ICU of the Federico II University Hospital in Naples, was carried out. Data were collected between January 2009 and December 2010 using the standard surveillance protocols and @entity580 of the National Healthcare Safety Network's ICU surveillance component. RESULTS: Out of 768 @entity1 hospitalized during this period, 434 with an ICU stay longer than 48 h were included in the study. Fifty-three @entity1 acquired a total of 71 @entity580 ; 55 (77,5%) ventilatorassociated @entity55 (VAP), 10 (14,1%), @entity281 ( @entity281 ) and 6 (8,4%) @entity293 ( @entity293 ). The overall @entity1 day rate was 12,9 @entity1 days. The @entity1 infection rate was 16,3 @entity1 at risk. The mean VAP rate was 15,0/1.000 ventilator days, the @entity281 rate 2,9/1.000 central line days and the @entity293 rate 1,2/1.000 catheter days. Of the @entity580 , 65 were Gram-negative, 6 Gram-positive and 5 fungal. The most frequent organism was @entity3064 (61,9%), followed by @entity796 (22,5%), Enterococcus fecalis (4,2%) and @entity5132 (4,2%). The crude mortality was 35% among @entity281 @entity1 . CONCLUSIONS: VAP was the most common @entity580 in our ICU. Gram-negative organisms were more commonly reported as etiologic agents of @entity281 .

title: [Epidemiology of hospital-acquired XXXX in an adult intensive care unit: results of a prospective cohort study].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['CLA-BSI', 'ICU-infected', 'central-line-associated bloodstream infection', 'ICU infections']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infection site definitions', 'nosocomial infection', 'nosocomial infections']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['catheter-associated urinary tract infection', 'CA-UTI']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infections']


abstract: BACKGROUND: Evidence-based guidelines recommend multivisceral resection for @entity1 with locally advanced adherent @entity14 because it reduces local recurrence and improves survival. However, this procedure can increase morbidity compared with standard resection and may not be practiced uniformly. We performed a population-based study to examine surgical practice and outcomes among @entity1 with locally advanced adherent @entity14 in the United States. METHODS: @entity1 who were 18 years or older and who had surgical resection for nonmetastatic, locally advanced adherent @entity14 from January 1, 1988, through December 31, 2002, were identified from the Surveillance, Epidemiology, and End Results (SEER) registry. Logistic regression was used to examine @entity1 , @entity5 , and geographic factors associated with multivisceral resection. Cumulative early mortality (i.e., at 1 and 6 months after diagnosis) and 5-year survival were obtained from Kaplan-Meier estimates; adjusted risks of @entity204 were calculated using Cox proportional hazards models. All statistical tests were two-sided. RESULTS: We identified 8380 @entity1 who underwent surgical resection for locally advanced adherent @entity14 , of whom 33.3% were managed with multivisceral resection. Among @entity694 @entity1 , younger age at diagnosis, female sex, SEER region, node negativity, and left-sided @entity5 were independently associated with having had a multivisceral resection. Among @entity5 @entity1 , younger age at diagnosis and female sex were positively and statistically significantly associated with multivisceral resection, whereas receipt of neoadjuvant radiation was inversely and statistically significantly associated with multivisceral resection. Compared with standard resection, multivisceral resection was associated with improved overall survival for @entity1 with colon (hazard ratio [HR] = 0.89, 95% confidence interval [CI] = 0.83 to 0.96) and rectal (HR = 0.81, 95% CI = 0.70 to 0.94) @entity5 , with no associated increase in early mortality. CONCLUSIONS: The majority of @entity1 with locally advanced @entity14 did not receive a multivisceral resection. The geographic variation in the application of this procedure in @entity1 with @entity694 suggests that local organizational structures and processes of care may play an important role in @entity1 treatment and, therefore, prognosis.

title: Population-based assessment of the surgical management of locally advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'cancer', 'rectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: INTRODUCTION: ARTOS was an international, prospective, non-interventional, non-controlled observational study designed to determine the effectiveness, safety, and tolerability of @entity3477 under daily-life conditions in @entity1 with complicated skin and skin structure @entity281 (cSSSIs) treated in Europe, the Middle East, and Asia-Pacific region. METHODS: Eligible @entity1 included males and females who were hospitalized @entity1 or outpatients requiring antibiotic therapy for cSSSIs and for whom the treating physician had elected to begin @entity3477 therapy in accordance with its approved indications. @entity1 were assessed before therapy and then at one or two follow-up visits. Effectiveness was assessed with respect to improvement and resolution of signs and symptoms of cSSSIs and safety with respect to the nature and frequency of adverse events and adverse drug reactions. RESULTS: A total of 6,594 @entity1 were enrolled of whom 5,444 had data available for analysis; 4,692 @entity1 received sequential intravenous/oral (IV/PO) @entity3477 and 752 exclusively IV therapy. A majority of @entity1 were aged between 40 and 79 years and had one or more comorbid conditions. @entity6081 , @entity272 , and @entity6 were the cSSSIs most frequently diagnosed and treated with @entity3477 , with almost 90% of @entity281 rated moderate or severe. Treating physicians chose sequential @entity3477 400 mg for most @entity1 , switching from IV to PO after 3-4 days. On average, treatment was maintained for 10 days. Treatment with @entity3477 was associated with rapid relief in symptoms, with 93.2% of @entity1 experiencing either complete resolution of symptoms or improvement at follow-up. @entity3477 was well tolerated with adverse drug reactions occurring in only 2% of @entity1 . CONCLUSIONS: This study, conducted in a 'real-world' setting, confirms the effectiveness and safety of @entity3477 in the treatment of a wide spectrum of cSSSIs seen in routine clinical practice.

title: XXXX in complicated skin and skin structure @entity281 (cSSSIs): A prospective, international, non-interventional, observational study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6081 :: ('MESH:D013530', 'Disease') :: ['Post-surgical wound infection']

entities_list: @entity3477 :: ('MESH:C104727', 'Chemical') :: ['moxifloxacin', 'Moxifloxacin']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic foot infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin abscess']

answer: @entity3477 :: (MESH:C104727,Chemical) :: ['Moxifloxacin']


abstract: OBJECTIVE: Hospital readmission after lower extremity bypass is a large cost burden and has become a focal point for policy change directed at disease-specific bundling strategies. The purpose of this study was to evaluate rates and predictors of 30-day readmission from a large, multicenter trial data set. METHODS: We analyzed the PRoject of Ex-Vivo vein graft ENgineering via Transfection III (PREVENT III) data set of 1404 @entity63 ( @entity63 ) @entity1 undergoing lower extremity vein graft bypass at 83 North American centers. The primary end point was readmission  <=30 days of discharge. Secondary end points included graft patency and limb salvage evaluated in the context of readmission. The data set was split into a two-thirds derivation set and a one-third validation set for the purposes of creating a risk prediction model. A whole number integer risk score was assigned to independent predictors of readmission. Summary risk scores were collapsed into categories and defined as low (0-1 points), medium (2-5 points), and high (>5 points). RESULTS: We analyzed 1356 vein graft bypass @entity1 , of which 23 (1.7%) died in-hospital and were excluded from the readmission analyses. In the derivation data set of 866 @entity1 , 211 (24.4%) were readmitted  <=30 days of discharge. The most common reasons for readmission were wound @entity281 in index leg (39.8%), an additional procedure in the index leg (20.8%), and nonvascular reasons (19%). By multivariable analysis, factors associated with 30-day hospital readmission (odds ratio [95% confidence limits]) included female gender (1.5 [1.0, 2.1]), current smoking (1.6 [1.1, 2.4]), in-hospital loss of graft patency (1.8 [1.0, 3.2]), dialysis (2.0 [1.2, 3.2]), and tissue loss (1.7 [1.1, 2.5]). In the derivation set, rates of readmission correlated to risk category. The 30-day readmission rates were 15.6% for low-risk @entity1 (0-1 points), 24.1% for moderate-risk (2-5 points) @entity1 , and 38.0% for high-risk (>5 points) @entity1 . Similarly, in the validation set, the rates were 16.5%, 25.4%, and 38.1% for low-, medium-, and high-risk groups, respectively. Thirty-day readmission was not associated with loss of long-term graft patency but was associated with long-term limb loss (hazard ratio, 2.1; 95% confidence interval, 1.4-3.1; P  = .0002). CONCLUSIONS: Readmission after lower extremity bypass for @entity63 is common (24%). Certain characteristics, such as female gender, current smoking, dialysis-dependence, tissue loss, and in-hospital graft-related events, are associated with increased risk. Readmission is associated with long-term limb loss. These data provide benchmark values for this complex @entity1 population and may prove useful when hospital readmission is used as a quality metric for hospital performance.

title: Risk prediction of 30-day readmission after infrainguinal bypass for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia', 'CLI']

answer: @entity63 :: (MESH:D007511,Disease) :: ['critical limb ischemia']


abstract: INTRODUCTION: The aim of this study was to examine the effect of the cellular composition of biopsies on the error rates of multigene predictors of response of @entity0 to neoadjuvant @entity632 and @entity786 (AC) chemotherapy. MATERIALS AND METHODS: Core biopsies were taken from primary @entity0 of 43 @entity1 prior to AC, and subsequent clinical response was recorded. Post-chemotherapy (day 21) samples were available for 16 of these samples. Frozen sections of each core were used to estimate the proportion of @entity3 and other tissue components at three levels. Transcriptional profiling was performed using a cDNA array containing 4,600 elements. RESULTS: Twenty-three (53%) @entity1 demonstrated a 'good' and 20 (47%) a 'poor' clinical response. The percentage invasive @entity5 in core biopsies collected from these @entity1 varied markedly. Despite this, agglomerative clustering of sample expression profiles showed that almost all biopsies from the same @entity5 aggregated as nearest neighbours. SAM (significance analysis of microarrays) regression analysis identified 144 genes which distinguished high- and low-percentage invasive @entity5 biopsies at a false discovery rate of not more than 5%. The misclassification error of prediction of clinical response using microarray data from pre-treatment biopsies (on leave-one-out cross-validation) was 28%. When prediction was performed on subsets of samples which were more homogeneous in their proportions of malignant and stromal cells, the misclassification error was considerably lower (8%-13%, p < 0.05 on permutation). CONCLUSION: The non- @entity5 content of @entity0 samples has a significant effect on gene expression profiles. Consideration of this factor improves accuracy of response prediction by expression array profiling. Future gene expression array prediction studies should be planned taking this into account.

title: The effect of the stromal component of XXXX on prediction of clinical outcome using gene expression microarray analysis.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast tumours', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast tumours']


abstract: BACKGROUND: The aim of this study was to investigate the efficacy and @entity137 of @entity1205 -based chemotherapy, and to investigate pretreatment factors that can predict @entity1349 ( @entity1349 ) in @entity1 with @entity263 ( @entity263 ). METHODS: From June 2005 to July 2010, 70 @entity1 with @entity263 underwent @entity1205 -based chemotherapy at Wakayama Medical University and related hospitals. @entity1205 was given at a dose of 70 mg/m(2) once every 3 weeks or 35 mg/m(2) twice every 3 weeks. Oral @entity12749 560 mg was given concurrently for five consecutive days during weeks 1 and 2 of each cycle, and @entity617 10 mg was given every day. @entity619 8 mg was premedicated intravenously before @entity1205 administration. RESULT: The @entity1 received a median of four cycles of treatment (range 1-31). In the serum @entity1486 response, 13 (18.6%) @entity1 achieved a complete response and 29 (41.4%) achieved a partial response. Median @entity1349 and time to progression were 14 months and 6 months, respectively. Median follow-up period was 9.5 months. Two independent pretreatment risk factors that predicted @entity1349 were visceral @entity3 including lymph node @entity3 and @entity417 . Grade 3/4 @entity1398 and @entity417 occurred in 25.7 and 8.6% of the @entity1 , respectively. Four treatment-related @entity204 were seen during the observation period. CONCLUSION: The combination of @entity1205 , @entity12749 and @entity617 was effective in Japanese @entity1 with @entity263 ; however, this combination therapy should be carefully indicated to elderly and/or poor performance @entity159 @entity1 due to its @entity137 . Visceral @entity3 and @entity417 were identified as independent risk factors which could predict @entity1349 .

title: @entity1205 in combination with @entity12749 and @entity617 for XXXX .

entities_list: @entity12749 :: ('MESH:D004961', 'Chemical') :: ['estramustine']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['castration-resistant prostate cancer', 'CRPC']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel', 'Docetaxel']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity263 :: (MESH:D011471,Disease) :: ['castration-resistant prostate cancer']


abstract: BACKGROUND: Asthma and @entity354 ( @entity354 ) are two common conditions among the responders to the WTC attacks. This study examined whether the cumulative incidence rates of @entity565 and @entity354 differed by sex among 24,022 and 23,557 WTC responders, respectively. METHODS: Cox proportional hazards regression was used to examine the sex difference in the rate of onset of physician-diagnosed @entity565 or @entity354 , from 9/12/2001 through 12/31/2015. RESULTS: The cumulative incidence of @entity565 reached 23% for @entity1 and 17% for @entity1 by the end of 2015, and the cumulative incidence of @entity354 reached 38% for @entity1 and 45% for @entity1 . Comparing @entity1 to @entity1 , the hazard ratio was 1.48 (95% confidence interval (CI): 1.27, 1.74) for @entity565 , and 1.25 (95% CI: 1.13, 1.38) for @entity354 . CONCLUSIONS: WTC general responders have a substantial burden of @entity565 and @entity354 , with higher incidence in @entity1 . Am. J. Ind. Med. 9999:XX-XX,    2016 Wiley Periodicals, Inc.

title: Sex differences in XXXX and @entity354 incidence among the World Trade Center Health Program general responder cohort.

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: PURPOSE: Primary @entity1104 ( @entity1104 ) and @entity7441 ( @entity7441 ) is the only curative option for @entity1 with @entity14 (PC). A significant proportion of @entity1 develop peritoneal recurrence. Outcomes of @entity1 undergoing secondary @entity1104 and @entity7441 for recurrent PC were examined. METHODS: All @entity1 undergoing second procedures with curative intent for recurrent appendiceal or @entity14 PC in three centers were included. @entity1 with recurrent @entity1725 ( @entity1725 ) were excluded. Morbidity and mortality, overall survival, and disease-free survival were primary outcome parameters. RESULTS: The study included 18 @entity1 (13 @entity14 ). At primary @entity1104 , mean @entity3906 Index (PCI) was 9.1. In 13 @entity1 complete resection was achieved. Median time to recurrence was 14 months (range: 1-33). At secondary @entity1104 , mean PCI was 6.3 and @entity1104 was complete in 13 @entity1 . There was no 30-day mortality and 1- and 2-year survival were 74% and 50%, respectively. In 14 @entity1 a recurrence after the second procedure was diagnosed. CONCLUSIONS: A secondary @entity1104 for recurrent @entity14 PC is safe and feasible, however, relapse is frequent. Further investigations are required to critically assess the efficacy of a secondary procedure and to define optimal @entity1 selection criteria in the era of effective modern chemotherapy.

title: Secondary @entity1104 and XXXX for peritoneal recurrence of @entity14 following prior primary cytoreduction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients', 'patient']

entities_list: @entity3906 :: ('MESH:D010534', 'Disease') :: ['Peritoneal Cancer']

entities_list: @entity1725 :: ('MESH:D011553', 'Disease') :: ['PMP', 'pseudomyxoma peritonei']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'colorectal cancer peritoneal carcinomatosis', 'colorectal and 5 appendiceal cancer', 'colorectal or appendiceal cancer']

entities_list: @entity1104 :: ('MESH:D000267', 'Disease') :: ['CRS', 'cytoreductive surgery']

entities_list: @entity7441 :: ('MESH:D056987', 'Disease') :: ['peri-operative intraperitoneal chemotherapy', 'PIC']

answer: @entity7441 :: (MESH:D056987,Disease) :: ['peri-operative intraperitoneal chemotherapy']


abstract: OBJECTIVE: To evaluate vaginal size and sexual activity after different techniques of feminization of external genitalia in @entity1 with @entity4998 . DESIGN: Retrospective clinical study. SETTING: @entity4998 @entity1 seen at our institution. @entity1 (S): Three female and 20 male @entity4998 raised as females. INTERVENTION(S): Bilateral orchidectomy, feminization of external genitalia (clitoridectomy or clitoroplasty, urogenital sinus enlargement), and/or neovaginoplasty or @entity384 with acrylic molds. MAIN OUTCOME MEASURE(S): Psychological evaluation, vaginal size, and quality of intercourse. RESULT(S): All @entity1 referred sexual drive to @entity1 . Fifty percent of the @entity1 who were submitted to neovaginoplasty @entity158 or @entity548 during sexual intercourse. On the other hand, 87% of the @entity1 who were submitted to @entity384 with acrylic molds, after genitoplasty or not, referred satisfactory sexual intercourse. All @entity1 who were submitted to clitoroplasty referred orgasm and 29% of the @entity1 submitted to clitoridectomy referred no orgasm. Of three @entity1 with @entity12554 , two became pregnant and delivered normal @entity1 through cesarian section. CONCLUSION(S): In @entity4998 with female social sex, surgical correction of external genitalia performed in childhood and @entity384 with acrylic molds performed when they wished to start having sexual intercourse resulted in best outcome.

title: Management of @entity4998 in @entity4998 : new perspectives on XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENT', 'men']

entities_list: @entity4998 :: ('MESH:D012734', 'Disease') :: ['Pseudohermaphrodite', 'pseudohermaphroditism', 'pseudohermaphrodites']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['vaginal dilation']

entities_list: @entity12554 :: ('MESH:C535979', 'Disease') :: ['congenital adrenal hyperplasia due to 21-hydroxylase deficiency']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['referred pain']

answer: @entity384 :: (MESH:D002311,Disease) :: ['vaginal dilation']


abstract: Two-dimensional echocardiography has a high specificity for the detection of @entity4615 , but technically difficult studies are often encountered. Ultrafast cardiac computed tomography may be useful in such cases. Using transthoracic two-dimensional echocardiography and ultrafast cardiac computed tomography, we studied 36 @entity1 with @entity2806 ; one @entity1 had the studies performed on two occasions, making a total of 37 sets of studies. Technical difficulties occurred in 12 echocardiographic (32%) and two ultrafast cardiac computed tomographic (5%) studies. The two techniques agreed in 29 sets of studies (78%). Among the eight discrepant sets of studies, two-dimensional echocardiography was positive for a @entity1002 while ultrafast cardiac computed tomography was negative in three and equivocal in one and echocardiography was equivocal while ultrafast cardiac computed tomography was negative in two and positive in one. In the latter case, a @entity1002 was confirmed at autopsy. In the other discrepant set of studies echocardiography was negative while ultrafast cardiac computed tomography revealed a left atrial and appendage @entity715 . Because of its ease of performance and safety, two-dimensional echocardiography is the appropriate initial screening test for @entity1002 . Ultrafast cardiac computed tomography can provide additional information in @entity1 with technically difficult or equivocal two-dimensional echocardiographic studies or @entity1 with @entity299 predisposing to @entity955 .

title: Comparison of two-dimensional echocardiography and ultrafast cardiac computed tomography for evaluating @entity4615 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity4615 :: ('MESH:C538262', 'Disease') :: ['intracardiac thrombi']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial thrombi formation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disorders']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular thrombus']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']


abstract: PURPOSE: To determine if there is a difference in @entity3816 during @entity231 surgery in very old @entity1 (> or = 88 years) compared with younger @entity1 (< 88 years). METHODS: The records of 802 consecutive @entity231 operations were reviewed. Identical techniques of small-incision phacoemulsification were used in all cases. A total of 102 eyes were in @entity1 aged 88 to 98, designated as the "very old." The remaining 700 eyes were in @entity1 under 88, designated as "younger." The incidence of @entity3816 in the 2 groups was compared. RESULTS: Posterior capsule tears, @entity393 , and loss of the nucleus were found as complications. Overall, these events occurred in 10% of the very old and in only 3% of those under age 88. @entity393 occurred in 7% of the very old and in only 1.6% of those under 88. There was 1 dropped nucleus in the very old. In the younger @entity1 , 90.5% of eyes with complicated surgery achieved 20/40 visual acuity or better, but only 40% of complicated cases in the very old achieved this. Furthermore, 50% of complicated cases in the very old had visual acuity of 20/200 or worse, all directly attributed to surgical difficulties. Fifteen percent of @entity1 in both groups had trabeculectomies with no influence on complications. We noted that 8% of the very old required pupil stretching compared with 2% of those under 88. CONCLUSIONS: This study strongly suggests that very old @entity1 (i.e., those 88 years and older) have a higher incidence of @entity3816 during @entity231 surgery than younger @entity1 . Furthermore, such complications may result in severe @entity227 . These findings may have significance as the population ages.

title: @entity3816 during XXXX surgery in the very old.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['Vitreous loss', 'vitreous loss']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['intraoperative complications']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']