abstract: OBJECTIVE: To explore the relationship between @entity4720 and @entity323 ( @entity323 ) and to evaluate the clinical characteristics of @entity3930 @entity1 with @entity323 . METHODS: Nineteen cases of @entity3930 @entity1 under 55 years old, who experienced some problems of their erectile function after the onset of @entity4720 , were surgically treated between March 2008 and March 2009 at our hospital. Their clinical characteristics were reviewed and clinical data prospectively analyzed. Preoperative and postoperative international index of erectile function (IIEF-5) and JOA (Japanese Orthopedic Association) scores and the correlation of improvement rate of these two scores were analyzed statistically. RESULTS: The average age of this @entity1 group was 48.8 years old. Twelve cases underwent anterior approach surgery while the other 7 cases posterior approach surgery. The mean follow-up period was 11.8 (5 - 18) months. All cases showed the clinical and radiological findings of spine cord compression. The preoperative and postoperative IIEF-5 scores were 12.1    5.6 and 17.6    5.5 respectively. There was obvious statistical difference between two scores (P = 0.002). Among all @entity1 , the erectile function of 84.2% improved on the last follow-up. The mean improvement rate of erectile function was 39.8% while the mean improvement rate of JOA scores 59.3%. But there was no correlation between these two rates (P = 0.172). The improvement rate of erectile function showed no statistical difference between two surgical approaches (P = 0.934) either. CONCLUSION: Cervical @entity1745 may be related with @entity323 besides motor and @entity409 . Surgical decompression may help to improve the erectile function. However, there is no correlation between the improvement rate of IIEF-5 scores and that of JOA scores. Future studies of a larger sample size are needed to further elucidate the underlying mechanism.

title: [Clinical study of @entity4720 and XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['male erectile dysfunction', 'ED']

entities_list: @entity3930 :: ('MESH:D005834', 'Disease') :: ['male cervical spondylosis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['sensory dysfunctions']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression']

entities_list: @entity4720 :: ('MESH:D055009', 'Disease') :: ['cervical spondylosis']

answer: @entity323 :: (MESH:D007172,Disease) :: ['male erectile dysfunction']


abstract: OBJECTIVE: To evaluate the efficacy and safety of fecal microbiota transplantation (FMT) combined with soluble dietary fiber and probiotics for @entity73 (STC). METHODS: Twenty-three @entity1 with STC from Jinling Hospital, Medical School of Nanjing University were prospectively enrolled between April 2015 and January 2016. STC @entity1 received FMT combined with soluble dietary fiber and probiotics. Fresh stool(100 g) was immediately mixed in a blender with 500 ml of 0.9% sterile saline for several seconds, which was then filtered through a gauze pad and a decreasing number of gauze screen (2.0 to 0.5 mm). The fecal bacteria suspension was stored frozen at -20centi-degree. The preparation time of FMT material was less than 1 hour. Total time of treatment was 9 days. An initial oral antibiotics( @entity2176 500 mg orally twice per day) was given for 3 consecutive days. Then the fecal microbiota(100 ml) was infused slowly(5 min) through nasojejunal tube for 6 consecutive days. After FMT, @entity1 were recommended to receive soluble dietary fiber (pectin, 8 g/d) and probiotics (bifid triple viable capsules, twice per day) for 4 weeks. Rates of clinical improvement and remission, adverse events, @entity1142 -related symptoms (PAC-SYM scores), bowel movements per week and gastrointestinal quality-of-life index (GIQLI) were recorded during the 12-week follow-up. This study was registered in the Clinical Trials.gov (NCT02016469). RESULTS: Among 23 @entity1 , 7 were male, 16 were female, the mean age was (49.6  14.7) years, the body mass index was (21.2  2.2) kg/m(2), the duration of @entity1142 was (8.3  5.9) years, and the defecation frequency was 1.8  0.7 per week. Compared with pre-treatment, @entity16180 -SYM scores decreased significantly from 2.3  0.5 to 1.3  0.4 at week 12 (P<0.01), defecation frequency increased from 1.8  0.7 per week to 4.8  2.0 per week at week 12 (P<0.01), and @entity1 felt satisfied with improved GIQLI score (from 78.5  15.5 to 120.8  21.3, P<0.01). During the follow-up, the clinical improvement and remission of STC @entity1 reached 69.6%(16/23) and 52.2%(12/23), respectively. No serious adverse events were observed. CONCLUSION: FMT combined with soluble dietary fiber and probiotics is safe and effective in treating @entity73 , which can improve the symptom and quality of life significantly.

title: [Short-term efficacy on fecal microbiota transplantation combined with soluble dietary fiber and probiotics in the treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['slow transit constipation']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

answer: @entity73 :: (MESH:D003072,Disease) :: ['slow transit constipation']


abstract: UNASSIGNED: 2044 Background: Bevacizumab (Bev), a monoclonal antibody targeting the @entity7 ( @entity7 ), has shown significant activity in a subset of @entity1 with @entity11 ( @entity11 ): to date no biological marker can predict the treatment benefit. Circulating endothelial cells (CEC) and progenitors ( @entity12563 ) have been observed in @entity5 @entity1 , reflecting ongoing @entity5 angiogenesis. METHODS: Forty-seven @entity11 @entity1 (38 @entity463 , GB; 9 @entity816 ), relapsing after radiotherapy and @entity2903 , were treated every 2 weeks with @entity1493 (10 mg/kg) and @entity2600 (125 or 340 mg/m2 depending on EIAEDs use). Adverse events were graded based on the CTC-AE v3.0. Before first treatment and every 8 weeks MRI and CEC and @entity12563 assessment were performed. Radiological responses were assessed based on RANO criteria. CEC and @entity12563 were enumerated in healthy controls (n=37) and @entity1 by six color flow cytometry as Syto+ @entity1195 - @entity2279 +/P1h12+ and Syto+ @entity1195 - @entity2279 +/CD133+ cells, respectively. The Kaplan Meier method estimated survival functions. RESULTS: Median age was 53 years (15-66), median Karnofsky Performance Status 70 (50-100). Median number of prior chemotherapy treatments: 2 (1-4). Median follow up: 6.5 months. Median PFS and @entity3012 were 6 and 10 months, respectively. For GB, 6M-PFS was 47% and 6M- @entity3012 68%. No central nervous system @entity548 were detected. No @entity1 developed grade 3-4 hematological @entity137 . One @entity1 experienced a small intralesional bleeding. When compared to controls, @entity11 @entity1 had a significantly lower CEC and @entity12563 at baseline (88.5   50 vs 140   171,p=0.03; 73.9    62.3 vs 181   167 p=0.001), but higher CD109+ CEC levels (91.5  78.3 vs 31  29). Interestingly, @entity1 with higher baseline level of CEC, @entity12563 and CD109+ CEC showed clinical benefit (i.e. PFS>= 4 months): 118.8    57.4 vs 80.8  43.2, p=0.002; 99.7  74d vs 60.4  51.7, p=0.04; 126.8  97.1 vs 76.3  64, p=0.002. No correlation between baseline @entity5 volume, 6M-PFS and CEC or @entity12563 enumeration was found. CONCLUSIONS: Investigation on CEC and @entity12563 could contribute to a better understanding of the action of @entity1493 in @entity11 @entity1 and help to identify responders.

title: Circulating endothelial cells and progenitors in recurrent high-grade @entity11 treated with bevacizumab and XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['high grade gliomas', 'HGG']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas']

entities_list: @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']

answer: @entity2600 :: (MESH:C051890,Chemical) :: ['irinotecan']


abstract: BACKGROUND: Protease inhibitor 2 derived from @entity415 (PI2) is claimed to reduce appetite and food intake, stimulate the satiety hormone @entity8586 (CCK) and lower postprandial @entity413 peaks when taken before a meal. However, current literature is inconclusive with regard to its efficacy and mechanism. Furthermore, the potential effect of PI2 on appetite motivational ratings without an immediately following meal has not previously been reported. OBJECTIVE: To comprehensively test the effects of 30 mg PI2 in a minidrink on appetite ratings, subsequent food intake, and plasma CCK and @entity413 responses. DESIGN: Minidrinks with or without 30 mg PI2 were compared in three separate substudies (A, B and C), each using a two-way, placebo-controlled, balanced-order, cross-over design and 23 or 24 subjects (mean over groups: body mass index 25.0 kg m(-2), range 22.5-30.7 kg m(-2); age 41.3, range 18-62 years). The minidrink was given (A) 120 or (B) 30 min before an ad libitum lunch or (C) 30 min before a fixed lunch. Study parameters were self-reported satiety (substudies A and C), ad libitum meal intake (substudies A and B), and (in an n=12 subset) plasma CCK and blood @entity413 in all substudies. All results were analyzed using analysis of covariance. Protease-inhibitory activity of the PI2-containing minidrinks was assessed under simulated gut conditions. RESULTS: PI2 did not differ from control for any study parameters, in any substudy, despite confirmation of the inhibitory activity of PI2. CONCLUSIONS: In this study protease inhibition using PI2 in a minidrink at a dose of 30 mg, as commercially used, had no (functional) efficacy on a range of behavioral and physiological appetite and intake control measures.

title: The effect of protease inhibitors derived from XXXX formulated in a minidrink on appetite, food intake and plasma @entity8586 levels in humans.

entities_list: @entity8586 :: ('MESH:D002766', 'Chemical') :: ['cholecystokinin']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity415 :: (4113,Species) :: ['potato']


abstract: In view of the theory that an excess of @entity904 causes release of cathepsins from intracellular lysosomes, @entity8853 was induced orally in the larvae of @entity1238 . It was predicted that the tails of these amphibia would undergo resorption prior to metamorphosis, since the presence of abundant lysosomes, associated with measurable increases of catheptic activity, had previously been demonstrated in the resorbing tails of amphibia during metamorphosis. This prediction was confirmed; after 3 to 4 weeks of @entity8853 , the tails of treated animals underwent partial resorption. Other transitory appendages, the rostral tentacles, collapsed after 2 weeks of treatment with an excess of @entity904 , an effect analogous to the collapse of @entity95 ' ears after intravenous papain. These effects were related to the loss of metachromatic extracellular material in these appendages. Excess of @entity904 caused @entity3792 and prognathos in the larvae. The hypervitaminotic larvae always developed a mucinous @entity294 , which was associated with a remarkable overgrowth of metachromatic goblet cells of the intestine. The entire intestine of the treated animals was more advanced in development than that of control larvae at equivalent stages. All the effects of @entity8853 were accelerated by the simultaneous administration of @entity701 . This was held to be due to liberation of @entity904 from hepatic stores by the @entity134 , and is in contrast to the retardation of @entity8853 by @entity701 in vitro.

title: CHANGES IN CONNECTIVE TISSUE AND INTESTINE CAUSED BY @entity904 IN AMPHIBIA, AND THEIR ACCELERATION BY XXXX .

entities_list: @entity1238 :: ('8355', 'Species') :: ['Xenopus laevis']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity904 :: ('MESH:D014801', 'Chemical') :: ['vitamin A']

entities_list: @entity3792 :: ('MESH:C565711', 'Disease') :: ['kyphoscoliosis']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity8853 :: ('MESH:D006986', 'Disease') :: ['hypervitaminosis A']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone']

answer: @entity701 :: (MESH:D006854,Chemical) :: ['HYDROCORTISONE']


abstract: OBJECTIVES: To standardize the TUNEL assay by establishing inter- and intraobserver variability, interassay variability, cutoff values, sensitivity and specificity of the assay, and studying the distribution of the DNA damage in a population of @entity249 @entity1 referred to a clinical andrology laboratory. METHODS: Seminal ejaculates from 25 healthy male volunteers (controls) and 194 @entity249 @entity1 (with @entity4810 ) referred to an andrology laboratory were examined for DNA damage by TUNEL assay using flow cytometric analysis. RESULTS: Both the inter- and intraobserver variability and interassay variability was small (<10%). DNA damage in the controls was 11.9    6.8% vs. 29.5    18.7% in @entity1 (P <.001). The cut-off value of 19.25% maximized the observed sensitivity (64.9%) and specificity (100%) of the assay. The distribution of DNA damage in the @entity1 was as follows: 14.9% (29 of 194) with DNA damage between 0% and 10%; 22.7% (44 of 194) between 10% and 20%; 8.8% (17 of 194) between 20% and 30%; and 17.5% (34 of 194) between 30% and 40%. Finally, 27.3% (53 of 194) had TUNEL values >40%. CONCLUSIONS: We report a detailed standardization of the TUNEL assay for clinical use, as well as reference ranges for DNA damage in normal healthy donors and @entity249 @entity1 . A cut-off of 19.25% with observed 100% specificity established in our program can differentiate @entity249 @entity1 with DNA damage from healthy @entity1 . This test can be offered to @entity249 @entity1 who are idiopathic, have severe oxidative stress-related abnormal semen quality, and contribute to the @entity249 problem of the couple who are considering assisted reproductive techniques.

title: TUNEL as a test for sperm DNA damage in the evaluation of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility', 'infertile']

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['male factor infertility']

answer: @entity4810 :: (MESH:D007248,Disease) :: ['male infertility']


abstract: Although the susceptibility of resting B lymphocytes to radiation-induced interphase death is well known, the mechanism by which this occurs is not understood. In this report, we use three measures of plasma membrane integrity (increase in cell volume, uptake of @entity3460 , and release of 51Cr) to assess the effect of radiation on the resting B cell plasma membrane. The delivery of 500 to 1000 rad caused the majority of resting B cells to enlarge slightly, whereas 3000 rad caused virtually all of the cells to approximately double in size within 3 to 4 hr. Measurement of the release of 51Cr from resting B cells revealed a similar relationship between the dose of radiation and the loss of radioactive label. @entity3460 exclusion was also found to diminish as a function of radiation dose. An analysis of a variety of lymphoid cells suggested that sensitivity to the membrane damaging effects of gamma radiation was in the order of resting B cells greater than resting T cells greater than a long-term L3T4+ T cell clone greater than a @entity1892 . LPS-induced B cell blasts treated with 3000 rad were equivalent to 1000 rad-treated resting B cells. The effects of the gamma radiation could be ameliorated by excluding @entity26 (a diradical molecule that can potentially enhance the generation and propagation of highly reactive free radicals) at the time of irradiation, or by adding the free radical scavenging agent @entity8488 . These data are compatible with the hypothesis that gamma radiation results in damage to the plasma membrane of resting lymphocytes via the generation of highly reactive free radical species. This damage is reflected in a rapid increase in plasma membrane permeability and swelling of the cells, and may play a major role in causing interphase death.

title: Effect of gamma radiation on resting B lymphocytes. I. XXXX -dependent damage to the plasma membrane results in increased permeability and cell enlargement.

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B cell lymphoma']

entities_list: @entity3460 :: ('MESH:D014343', 'Chemical') :: ['trypan blue', 'Trypan blue']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity8488 :: ('MESH:D003543', 'Chemical') :: ['cysteamine']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['Oxygen']


abstract: BACKGROUND: There are few epidemiological studies on @entity16 in Albania. METHODS: A door-to-door survey was undertaken in two geographical areas (Tirana and Saranda) with different socioeconomic backgrounds. Two random samples of the local population underwent a structured interview to ascertain @entity10 , @entity302 , @entity303 , @entity304 , @entity15 , @entity305 , @entity64 and @entity306 . Each diagnosis was made using standard criteria for epidemiological studies and was confirmed by history, neurological examination and, where available, the review of personal medical records. Lifetime prevalence ratios with 95% confidence intervals were calculated. RESULTS: Of the 9,869 individuals screened (Tirana 4,953; Saranda 4,916), 4,867 were males aged 1-91 years (median 39 years) and 5,002 were females aged 1-96 years (median 37 years). Crude prevalence ratios ( @entity307 ,000) were: @entity10 241.9 (233.5-250.3), @entity305 32.5 (29.0-36.0), @entity302 14.2 (11.7-16.3), @entity64 12.4 (10.2-14.6), @entity303 9.6 (7.7-11.5), @entity304 8.0 (6.2-9.8), @entity306 4.8 (3.4-6.2), and @entity15 0.3 (0.0-0.6). Prevalence varied with age and gender, with differences across diseases. Except for @entity305 (Tirana 39.8; Saranda 25.2), ratios were not different in the two study areas. CONCLUSIONS: The prevalence of selected @entity16 in Albania is higher than in other countries. Differences may be explained by study design, population structure and/or genetic and environmental factors.

title: High prevalence of major XXXX in two Albanian communities: results of a door-to-door survey.

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['parkinsonism']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders']

entities_list: @entity305 :: ('MESH:D011115', 'Disease') :: ['polyneuropathy']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity16 :: (MESH:D009422,Disease) :: ['neurological disorders']


abstract: Although no randomized trials are available, surgical resection is a widely accepted treatment for selected @entity1 with pulmonary @entity3 . Specific criteria have been well defined and a macroscopic complete resection should be obtained. Important prognostic factors include histology, number of @entity3 and disease-free interval. However, even after complete resection, 5-year survival rates remain disappointingly low and many @entity1 will have recurrent disease confined to the chest. For this reason, locoregional therapies are extensively investigated at the present time. These include biochemical and biophysical methods. Due to @entity137 of high doses of intravenous chemotherapy, the main purpose is to deliver high-dose chemotherapy to the lung without systemic side-effects. @entity887 , pulmonary artery infusion and isolated lung perfusion are most intensively studied. These techniques were found to be feasible and are able to deliver a high local concentration of chemotherapeutic drugs. The results of further phase II trials are awaited for to determine their effect on local recurrence and long-term survival.

title: Surgical resection of lung XXXX including the role of locoregional therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['Chemo-embolization']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: An @entity432 was produced by thrombin-induced coagulation in the left anterior descending coronary artery of 18 open chest @entity6599 . In six control animals, occlusive @entity715 persisting for 4 hours resulted in a large transmural @entity1188 (66 +/- 4% of the perfusion area, mean +/- SEM). In six animals, single chain urokinase-type plasminogen activator, obtained by recombinant @entity3141 (DNA) technology, was infused intravenously at a rate of 20 micrograms/kg per min for 60 minutes after approximately 45 minutes of coronary @entity715 . Persistent reperfusion occurred within 21 +/- 4 minutes (mean +/- SD). The mean duration of occlusion before reperfusion was 72 +/- 6 minutes. Recanalization resulted in a reduction of @entity1188 size (42 +/- 4%, p less than 0.01 versus control animals). Myocardial blood flow in the perfusion area of the left anterior descending coronary artery was 107% of normal 2.5 hours after recanalization. The infusion of recombinant single chain urokinase-type plasminogen activator was not associated with systemic activation of the fibrinolytic system, fibrinogen breakdown or evident @entity548 . In six @entity6599 recombinant low molecular weight urokinase (molecular weight 33,000) was infused intravenously at a rate of 20 micrograms/kg per min for 60 minutes after approximately 45 minutes of coronary @entity715 . Persistent reperfusion occurred within 14 +/- 5 minutes (p less than 0.05 versus recombinant single chain urokinase-type plasminogen activator). The mean duration of occlusion was 69 +/- 14 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Coronary thrombolysis by intravenous infusion of recombinant single chain urokinase-type plasminogen activator or recombinant urokinase in @entity6599 : effect on regional blood flow, XXXX size and hemostasis.

entities_list: @entity3141 :: ('CHEBI:16991', 'Chemical') :: ['deoxyribonucleic acid']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusive thrombus']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['infarct']


abstract: Agents targeting @entity7 ( @entity7 ) have been validated as cancer therapeutics, yet efficacy can differ widely between @entity5 types and individual @entity1 . In addition, such agents are costly and can have significant @entity137 . Rapid noninvasive determination of response could provide significant benefits. We tested if response to the anti- @entity7 antibody bevacizumab (BV) could be detected using contrast-enhanced ultrasound imaging (CEUS). We used two xenograft model systems with previously well-characterized responses to @entity7 inhibition, a responder (SK- @entity1471 ) and a non-responder (NGP), and examined perfusion-related parameters. CEUS demonstrated that BV treatment arrested the increase in blood volume in the SK- @entity1471 @entity5 group only. Molecular imaging of a(V)b(3) with targeted microbubbles was a more sensitive prognostic indicator of BV efficacy. CEUS using RGD-labeled microbubbles showed a robust decrease in a(V)b(3) vasculature following BV treatment in SK- @entity1471 @entity5 . Paralleling these findings, lectin perfusion assays detected a disproportionate pruning of smaller, branch vessels. Therefore, we conclude that the response to BV can be identified soon after initiation of treatment, often within 3 days, by use of CEUS molecular imaging techniques. The use of a noninvasive ultrasound approach may allow for earlier and more effective determination of efficacy of antiangiogenic therapy.

title: Contrast ultrasound imaging for identification of early responder XXXX models to anti-angiogenic therapy.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: Retrospective analysis was undertaken of 24 @entity1 with @entity4615 surgically treated. There were 19 males and 5 females, ranging in age from 10 to 69 years (mean 44.6 years). 22 myxomata were located in the left atrium and 2 in the right atrium. Clinical manifestations and cardiac catheterization findings are described. All @entity5 were resected with the aid of extracorporeal circulation. The operation consisted of @entity5 , with a generous excision of septal attachment in 17 cases; patch reconstruction of the atrial septum was required in most @entity1 . One @entity1 had a concomitant correction of atrial septum defect, another required mitral annuloplasty, and third had a concomitant aorto-coronary bypass. There were 3 hospital deaths (operative mortality 12.5%) and 2 @entity1 (one died) had intraoperative @entity5 emboli. In a follow-up extending to 11 years (mean 38 months), there were not late deaths and functional results were generally excellent (15 surviving @entity1 are in N.Y.H.A. class I). No @entity1 had evidence of recurrence of the @entity5 .

title: [ XXXX : clinical features and results of surgical treatment in 24 cases (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4615 :: ('MESH:C538262', 'Disease') :: ['atrial myxomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'removal of the tumor', 'tumors']

answer: @entity4615 :: (MESH:C538262,Disease) :: ['Atrial myxoma']


abstract: BACKGROUND AND AIMS: In @entity2 , many factors have prognostic significance, including @entity1148 , which is frequently observed. Associations between vascular events, which are the outcomes of @entity1109 , and mortality and morbidity has been evaluated in many studies. The aim of the present study was to evaluate the relationship between @entity1148 and vascular events. MATERIALS AND METHODS: In total, 281 @entity1 , who were histopathologically diagnosed with @entity2 between March 2007 and August 2009, were evaluated retrospectively. Data analysis was performed using the Statistical Package for the Social Sciences (SPSS) software (ver. 11.5 for Windows). Analysis of the distribution of constant variance for normality was assessed using the Shapiro-Wilk test. Nominal variables were evaluated using Pearson's chi-squared or Fisher's exact chi-squared tests. Significant correlations between continuous variables were investigated using Spearman's correlation test. RESULTS: Of the 281 @entity1 , 234 (83.3%) were males and 47 (16.7%) were females, with a median age of 60.6 (31-83 years). Histopathologically, 40 (14.2%) were diagnosed with @entity151 and 241 (85.8%) with @entity1149 . In total, 17 (6.04%) vascular events were identified: 11 (64.7%) @entity1150 , three (17.6%) @entity1151 , one (5.9%) cerebral arterial @entity715 , and one (5.9%) vena cava superior @entity715 . @entity1148 was not determined during @entity715 , but during subsequent visits. CONCLUSIONS: @entity1148 is frequently observed in @entity1 with @entity2 . Further prospective studies are required to evaluate the need for prophylactic anticoagulants in these @entity1 . The association between vascular events and survival, the next step of the present study, will be evaluated prospectively.

title: Vascular events in XXXX .

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['Thrombocytosis', 'thrombocytosis']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['paraneoplastic symptoms']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary thromboembolisms']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thromboses']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['small-cell lung cancer']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: @entity491 may be found in @entity1 with @entity2 either at time of diagnosis or during the course of the disease. Though mild @entity491 is common in @entity2 , hyperleukocytosis defined as total leukocyte count more than 100,000 is uncommon. We describe a 68-year-old chronic smoker who presented with osteolytic pelvic @entity79 and hyperleukocytosis, who on evaluation was found to have a primary @entity2 . Bone marrow aspiration and biopsy showed marked @entity1373 . Myeloid series comprised predominantly mature neutrophils and stab forms. Cytogenetic investigation showed a normal chromosome set (46, XY). Repeated cultures from blood, urine, and sputum were sterile. He was started on chemotherapy but had a progressive downhill course. In @entity1 with @entity2 , @entity491 can be due to infection, use of corticosteroid or hematopoetic growth factors, bone marrow involvement, or @entity8231 manifestation. @entity491 is associated with poor prognosis and @entity146 .

title: Hyperleukocytosis, an unusual @entity8231 manifestation of XXXX : Case report and review of literature.

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['myeloid hyperplasia']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesion']

entities_list: @entity8231 :: ('MESH:D010257', 'Disease') :: ['paraneoplastic']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['Paraneoplastic leukocytosis', 'Leukocytosis', 'leukocytosis']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: AIMS: @entity1557 ( @entity1557 ) and @entity5 ( @entity5 ) are @entity5 . Mutations in @entity6530 exon 2 have been reported in @entity1557 . This study investigated the @entity6530 mutations in a spectrum of @entity5 . METHODS AND RESULTS: Using direct sequencing, we analysed @entity6530 exon 2 mutations on 121 samples, including @entity5 and @entity1557 and variants. We found @entity6530 mutations in 71.4% of @entity5 . No significant difference in the mutation frequency was observed between benign, borderline and malignant @entity5 , and a general lack of correlation existed between mutations and pathological factors associated with PT grading. The mutation patterns were similar between @entity5 and @entity1557 , with codon 44 being involved most frequently. @entity6530 mutations were identified in 47.1, 52.6 and 50.0% of complex @entity1557 , juvenile @entity1557 and tubular @entity652 (TAs), respectively, and the frequency and mutation patterns were similar between these FA variants and usual @entity1557 . CONCLUSIONS: The high frequency and similar patterns of @entity6530 mutations in @entity1557 and various grades of @entity5 implies that the @entity6530 mutation is a common and early pathological event in these @entity5 . The similar frequency and patterns of the @entity6530 mutation between @entity1557 and variants suggests that FA variants are bona fide @entity1557 , with identical pathogenesis involving @entity6530 mutations.

title: Mutational analysis of @entity6530 exon 2 in a spectrum of XXXX of the breast: implications for pathogenesis and histogenesis.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['fibroepithelial tumours', 'phyllodes tumours', 'PTs']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

entities_list: @entity1557 :: ('MESH:D018226', 'Disease') :: ['Fibroadenomas', 'FAs']

answer: @entity5 :: (MESH:D009369,Disease) :: ['fibroepithelial tumours']


abstract: The classification within @entity12047 is currently under debate. To assess the reproductive potential between the G1 and G6 strains, an experimental double @entity281 was carried out in a @entity235 . First, two fertile hydatid cysts were collected in Algeria from a @entity291 and a @entity20770 . They were identified as being G1 and G6 with the markers coxI and nadI. Subsequently, a @entity235 was inoculated with protoscoleces from these two cysts. Sixty days after @entity281 , 85 adult worms were recovered from the intestine of the @entity235 . Then, the two cysts and each of these individual parasites were characterized with the multilocus microsatellite EmsB and compared. For all worms, the scolex and the gravid proglottids, separately analyzed, provided an identical profile: the G1 profile was observed in 70 adults, and the G6 profile in the 15 others. No single worm exhibited a hybrid G1/G6 profile. This result suggests the absence of cross-fertilizing between the two taxa under the given experimental conditions, and so, the presence of a strong cross-reproductive barrier. This observation corroborates with the recent reclassification of G1 and G6 within two distinct species.

title: Failure to observe cross-fertilization between the XXXX G1 and G6 strains after an experimental mixed @entity281 of the definitive host.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity12047 :: ('6210', 'Species') :: ['Echinococcus granulosus']

answer: @entity12047 :: (6210,Species) :: ['Echinococcus granulosus']


abstract: Periodontal infections increase the risk of @entity731 via partly unresolved mechanisms. Of the natural IgM Abs that recognize molecular mimicry on bacterial epitopes and modified lipid and protein structures, IgM directed against oxidized low-density lipoprotein (LDL) is associated with atheroprotective properties. Here, the effect of natural immune responses to @entity1234 -modified LDL ( @entity1865 -LDL) in conferring protection against @entity731 , which was accelerated by the major periodontopathogen @entity2523 , was investigated. @entity1748 -deficient ( @entity1748 (-/-)) @entity19 were immunized with @entity19 @entity1865 -LDL without adjuvant before topical application challenge with live @entity2523 . @entity731 was analyzed after a high-fat diet, and plasma IgG and IgM Ab levels were measured throughout the study, and the secretion of @entity59 , @entity1618 and IFN-y in splenocytes stimulated with @entity1865 -LDL was determined. @entity1748 (-/-) @entity19 immunized with @entity1865 -LDL had elevated IgM and IgG levels to @entity1865 -LDL compared with saline-treated controls. @entity1865 -LDL immunization diminished aortic lipid depositions after challenge with @entity2523 compared with @entity19 receiving only @entity2523 challenge. Immunization of @entity1748 (-/-) @entity19 with homologous @entity1865 -LDL stimulated the production of @entity59 , implicating general activation of B-1 cells. Immune responses to @entity1865 -LDL protected from the @entity2523 -accelerated @entity731 . Thus, the linkage between bacterial infectious burden and @entity731 is suggested to be modulated via natural IgM directed against cross-reactive epitopes on bacteria and modified LDL.

title: Immunization with XXXX -modified low-density lipoprotein (LDL) reduces @entity731 in @entity1748 -deficient @entity19 challenged with @entity2523 .

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis', 'atherogenesis', 'atherosclerotic vascular disease']

entities_list: @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']

answer: @entity1234 :: (MESH:D008315,Chemical) :: ['malondialdehyde']


abstract: The acquisition of resistance to conventional therapies such as radiation and chemotherapeutic drugs remains the major obstacle in the successful treatment of @entity5 @entity1 . @entity5 cells acquire resistance to apoptotic stimuli and it has been demonstrated that conventional therapies exert their cytotoxic activities primarily by inducing apoptosis in the cells. Resistance to radiation and chemotherapeutic drugs has led to the development of immunotherapy and gene therapy approaches with the intent of overcoming resistance to drugs and radiation as well as enhancing the specificity to eliminate @entity5 cells. However, cytotoxic lymphocytes primarily kill by apoptosis and, therefore, drug-resistant @entity5 cells may also be cross-resistant to immunotherapy. To evade apoptosis, @entity5 cells have adopted various mechanisms that interfere with the apoptotic signaling pathways and promote constitutive activation of cellular proliferation and survival pathways. Thus, modifications of the antiapoptotic genes in @entity5 cells are warranted for the effectiveness of conventional therapies as well as novel immunotherapeutic approaches. Such modifications will avert the resistant phenotype of the @entity5 cells and will render them susceptible to apoptosis. Current studies, both in vitro and preclinically in vivo, have been aimed at the modification and regulation of expression of apoptosis-related gene products and their activities. A novel protein designated @entity3218 ( @entity3218 ) has been partially characterized. @entity3218 is a member of the @entity3633 -binding protein family. @entity3218 has been shown to disrupt the @entity24117 [mitogen-activated protein kinase-ERK (extracellular signal-regulated kinase) kinase-1/2]-ERK1/2 and NF-kappaB signaling pathways, via physical interaction with @entity24117 and NF-kappaB-inducing kinase or transforming growth factor beta-activated kinase-1, respectively, thereby abrogating the survival and antiapoptotic properties of these signaling pathways. In addition, @entity3218 has been shown to act as a signal modifier that enhances receptor signaling by inhibiting G protein-coupled receptor kinase-2. By regulating cell signaling, growth, and survival through its expression and activity, @entity3218 is considered to play a pivotal role in @entity5 , regulating apoptosis induced by drugs or immune-mediated stimuli. Overexpression of @entity3218 sensitizes @entity5 cells to chemotherapeutic drug-induced apoptosis. Also, induction of @entity3218 by drugs or anti-receptor antibodies sensitizes @entity5 cells to drug-induced apoptosis. In this review, we discuss the discovery, structure, function, and significance of @entity3218 in @entity5 .

title: XXXX : structure, function, regulation of cell signaling, and pivotal role in apoptosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Tumor']

entities_list: @entity3218 :: ('5037', 'Gene') :: ['Raf-1 kinase inhibitor protein', 'RKIP']

entities_list: @entity3633 :: ('MESH:C483858', 'Chemical') :: ['phosphatidylethanolamine']

answer: @entity3218 :: (5037,Gene) :: ['Raf-1 kinase inhibitor protein']


abstract: OBJECTIVE: To determine the effect of low dose interferon alfa ( @entity1 lymphoblastoid interferon) on aminotransferase activities in @entity6194 . DESIGN: Prospective randomised controlled parallel group study of active treatment versus no treatment carried out over 16 weeks and preceded by baseline measurements at weeks 8 and 4 and time zero. SETTING: HEPATOLOGY outpatient clinics in secondary referral centres. @entity1 : Fourteen adults with histologically proved chronic @entity99 and persistently raised aminotransferase activities for six months or more. INTERVENTIONS: Seven @entity1 randomised to receive interferon alfa 5 megaunits (MU) daily for one week, reducing to 5 MU thrice weekly for seven weeks, then 3 MU thrice weekly for eight weeks. Controls not treated. END POINT: Control of hepatic enzyme activity in @entity6194 . MEASUREMENTS AND MAIN RESULTS: Serum @entity492 aminotransferase activity remained raised in controls (mean increase in study period 23.4 U/l) but fell rapidly to normal in the treated group (mean decrease 106.4 U/l). In four cases values were normal by eight weeks and in five cases by 16 weeks. Only minor side effects were recorded (fever, @entity925 ), which became less common as treatment progressed. CONCLUSIONS: Continuous low dose interferon alfa reduces @entity492 aminotransferase activity to normal in most @entity1 with @entity6194 and may prevent progression to @entity82 .

title: Randomised controlled trial of interferon alfa (lymphoblastoid interferon) in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity6194 :: ('MESH:D019694', 'Disease') :: ['chronic non-A non-B hepatitis']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

answer: @entity6194 :: (MESH:D019694,Disease) :: ['chronic non-A non-B hepatitis']


abstract: Investigated the effects of a provocation on aggression for three types of @entity167 users. The @entity167 Use Inventory was used to select 30 light-moderate and 30 moderate drinkers. Thirty abstainers were selected as a control group. Half of each group was assigned randomly to one of two treatments, a provocation or a no-provocation. After treatment, each S completed the @entity1168 ( @entity1168 ) @entity146 scales and the Multiple Affect Adjective Checklist (MAACL). The results of this study indicated that, for both instruments, the provocation elicited significantly more feelings of hostility and @entity146 than the no-provocation. However, there were no significant level effects, nor was there a significant interaction between level of drinking and presence of a provocation. The failure to find significant level effects was attributed to the abstainers' scores. With the abstainer category excluded from the analysis, additional findings resulted in significant level effects for the MAACL hostility scales, but not for the @entity146 scales. It was recommended that future studies investigate risk factors of abstinence and eliminate the abstainer category as a control.

title: The effects of a provocation on aggression for three types of XXXX users.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol', 'Alcohol']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['Adjective Rating Form', 'ARF']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['verbal aggression', 'ARF verbal aggression']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']


abstract: OBJECTIVE: To describe preserved @entity73 in @entity1 with @entity303 . DESIGN: Case series. SETTING: Community clinic. @entity1 : Five @entity1 who met National Institute of @entity16 and @entity195 and @entity74 Association criteria for probable @entity195 and were claimed to retain a cognitive skill. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Standard neuropsychological tests and individualized measures of @entity1 's skilled behaviors. For @entity1 who remained skilled at games, performance was compared with that of normal controls in direct competition. For the @entity1 -trombonist, raters compared premorbid and postmorbid recordings of his play. RESULTS: One @entity1 continued to play the trombone in a Dixieland band, although he could not name well-known numbers that he played. Another continued to solve adult jigsaw puzzles. A third @entity1 retained skill at canasta, the fourth at dominoes. The fifth @entity1 remained a skillful contract bridge player, although he could not name the suits or articulate simple bidding rules. Four @entity1 had impaired performance on standard anterograde and remote memory and naming tests but performed normally on pursuit rotor and letter fluency tests. Mini-Mental State Examination scores for these @entity1 ranged from 10 to 22. One @entity1 refused neuropsychological testing but displayed his skill. CONCLUSIONS: Together with previous studies of preserved piano playing or painting skills, our findings indicate that a broad range of complex cognitive abilities may be preserved in @entity1 with @entity303 of the Alzheimer type who cannot perform simpler actions.

title: Preserved XXXX in @entity303 of the Alzheimer type.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive skills']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological and Communicative Disorders']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Related Disorders']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Stroke-Alzheimer's Disease", "Alzheimer's disease"]

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive skills']


abstract: Freezing reaction ( @entity8364 ) is a natural passive defensive strategy in animals. An exaggerated form of @entity8364 is a symptom of grave @entity75 . @entity8364 in @entity19 was shown to be linked to the @entity9682 , @entity9683 , @entity9684 , and @entity9685 genes as potential candidates for a high predisposition to @entity8364 . The study sought to test the hypothesis of an association between @entity8364 and expression of these genes in the brain. Thegenes' mRNA levels were measured in the hypothalamus, hippocampus, frontal cortex, striatum, and midbrain of @entity8364 -resistant AKR/J strain and @entity8364 -prone strains CBA/Lac, ASC (antidepressant-sensitive cataleptic) and the congenic line AKR.CBA-D13M76C. No association between expression of any investigated genes and predisposition to @entity8364 was found. At the same time, multivariate analysis revealed interactions among the expressions of @entity9682 , @entity9683 , @entity9684 , and @entity9685 genes in the brain structures. A factor analysis of all variables produced two independent factors explaining 76.2% of the total variance. The @entity8364 -resistant AKR strain was distinguished from the @entity8364 -prone strains CBA, ASC, and AKR.CBA-D13M76C by factor 1. It was suggested that a high predisposition to @entity8364 in @entity19 can be defined by the @entity9682 , @entity9683 , @entity9684 , and @entity9685 genes' coexpression network.

title: XXXX , @entity9683 , @entity9684 , and @entity9685 gene coexpression network in the mechanism of freezing reaction in @entity19 .

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain dysfunction']

entities_list: @entity8364 :: ('MESH:D002375', 'Disease') :: ['Catalepsy', 'catalepsy']

answer: @entity9682 :: (26401(Tax:10090),Gene) :: ['Map3k1']


abstract: @entity3852 ( @entity3852 ) is a @entity146 of the skin. The recently identified @entity6059 (MCPyV) is present in the majority of MCCs. MCPyV clonally integrates in the @entity5 DNA and @entity5 -specific viral mutations are detected within the large T-antigen. To elucidate a possible role of MCPyV in the pathogenesis of other @entity1489 ( @entity1489 ), i.e. @entity957 , @entity1490 and @entity1491 we tested a group of these @entity5 in immunosuppressed and immunocompetent @entity1 . In addition we tested MCPyV-positive @entity5 for viral mutations within the large T-antigen. MCPyV DNA was significantly more frequently detected in the @entity1489 of the immunosuppressed @entity1 (p<0.001). No @entity5 specific mutations were found within the large T-antigen. The presence of the virus in @entity5 cells was confirmed by FISH analysis. Although MCPyV is present in the @entity5 cells of @entity957 , @entity1490 and @entity1491 , further investigations into the role of MCPyV in the pathogenesis of these @entity5 is needed.

title: [ XXXX in the pathogenesis of @entity1489 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3852 :: ('MESH:D015266', 'Disease') :: ['Merkel cell carcinoma', 'MCC']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['very aggressive neuroendocrine carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanoma skin cancers', 'NMSC']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity6059 :: ('493803', 'Species') :: ['Merkel cell polyomavirus']

entities_list: @entity1490 :: ('MESH:D001913', 'Disease') :: ["Bowen's disease"]

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'basal cell skin carcinoma']

answer: @entity6059 :: (493803,Species) :: ['Merkel cell polyomavirus']


abstract: STUDY OBJECTIVE: To examine the postoperative course and outcomes of young females with @entity43 treated with @entity43 . The secondary objective was to determine which operative findings correlated with higher follicular counts following detorsion. DESIGN: Retrospective chart review. SETTING: Tertiary academic center. @entity1 : 29 females (mean age 10.3    4.9 y) who underwent surgery for @entity43 with @entity43 at our institution between July 2007 and July 2010 and who had follow-up pelvic ultrasonography available for review. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Surgical findings, @entity260 , and follicular counts on follow-up ultrasonography. RESULTS: Mean duration of @entity490 on presentation was 77.5    78.8 h. The detorsed ovary was described as "dusky/purple" in 21 cases (72.4%), "normal" in 1 (3.4%), " @entity39 " in 1 (3.4%), and not described in 6 (20.7%). All pubertal @entity1 resumed menstrual function. No @entity1 required reoperation for removal of the salvaged ovary. There were no instances of postoperative @entity221 or concern for @entity2670 . Average timing of follow-up ultrasonography was 8.1    6.7 months, with 28 @entity1 (96.6%) showing ovarian follicles on the affected side (mean 4.6    1.9 and 4.7    3.3 follicles on the right and left ovary, respectively). No correlation was found between the side affected, gross appearance of the torsed ovary or the number of follicles found on follow-up ultrasonography. CONCLUSIONS: Detorsion with ovarian preservation is a safe and effective treatment, and should be considered the primary treatment for @entity1 with @entity43 , even for those with ovaries that appear @entity39 .

title: Outcome Following Detorsion of Torsed Adnexa in XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian torsion', 'detorsion and ovarian preservation']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'girls', 'PARTICIPANTS']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian venous thrombosis']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: Left ventricular (LV) work-function curves were used to assess LV performance in eight postoperative @entity215 ( @entity215 ) @entity1 who underwent repair before 2 years of age (group 1) and 12 @entity1 who underwent repair after 2 years of age (group 2). All @entity1 were without significant residual shunts or @entity849 . Results were compared with those in seven control @entity1 . Left- and right-heart hemodynamics were measured at various levels of afterload induced by @entity7202 while heart rate was maintained constant. Cardiac output was serially measured. The slope (m) for each @entity1 's LV end-diastolic pressure (EDP) vs LV minute-work index (MWI) relationship was determined. There were no significant differences in resting cardiac index, LV systolic pressure, LVEDP, aortic @entity26 saturation or MWI among the groups. However, with afterload stress, group 2 @entity1 had abnormal work-function curves with @entity308 (m = 0.21 +/- 0.04) compared with the values for group 1 @entity1 (m = 0.89 +/- 0.13, p less than 0.001) or the control group (m = 1.13 +/- 0.12, p less than 0.001). Thus, @entity1002 unmasked by an afterload stress was present in the older @entity215 @entity1 but not in the @entity1 repaired during infancy. These findings raise the possibility that early, definitive repair of @entity215 may help preserve postoperative LV function.

title: Left ventricular function after repair of XXXX and its relationship to age at surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity7202 :: ('MESH:D008729', 'Chemical') :: ['methoxamine']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed slopes']

entities_list: @entity215 :: ('MESH:D013771', 'Disease') :: ['TOF', 'tetralogy of Fallot']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['pulmonary stenosis']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV dysfunction']

answer: @entity215 :: (MESH:D013771,Disease) :: ['tetralogy of fallot']


abstract: OBJECTIVE: To determine the utility of the @entity19018 breath test in confirming the eradication of @entity1534 . METHODS: We reviewed our @entity1534 database for @entity1 who underwent @entity19018 breath test at baseline and 6 wk after triple therapy with @entity803 , @entity868 , and @entity19019 . Baseline @entity281 was defined by the identification of the organism on antral biopsies or a reactive CLO test. Eradication was defined as a negative Warthin-Starry stain and a non-reactive CLO test at 24 h. All @entity1 had a positive baseline [13C] @entity1133 breath test defined as [13C] enrichment > 6% at 60 min. RESULTS: One hundred eighteen @entity1534 -infected @entity1 (mean age 58.3 +/- 13.9 yr) met the review criteria (61 duodenal ulcers, 24 gastric ulcers, 33 non-ulcer @entity2210 ). In 101/118 @entity1 (86%), @entity1534 was successfully eradicated (mean baseline breath test value 25.8 +/- 1.6). Of 101 @entity1 , 95 had a negative 6-wk follow-up breath test (mean 2.2 +/- 0.2, p < 0.001). Of the 6/101 @entity1 in whom treatment was successful, and who remained breath test positive at 6 wk, 4/6 were breath test negative when retested at 3 months. The remaining two @entity1 were lost to follow-up. In 17/118 (14%) @entity1 , @entity1534 failed to be eradicated (mean baseline breath test 22.4 +/- 3.6). Fifteen of 17 @entity1 had a positive breath test at 6 wk (mean 19.9 +/- 3.7). Two of 17 with a negative breath test at 6 wk tested positive when the breath test was repeated at 3 months. The sensitivity and specificity of @entity19018 breath test at 6 wk posttreatment are 97% and 71%, respectively. The positive and negative predictive values are 94% and 88%, respectively. CONCLUSIONS: @entity19018 breath test is a sensitive indicator of @entity1534 eradication 6 wk after treatment. Antral biopsies are unnecessary to confirm eradication of @entity1534 after completion of treatment.

title: XXXX breath test to confirm eradication of @entity1534 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity19019 :: ('MESH:C015715', 'Chemical') :: ['bismuth subsalicylate']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1534 :: ('210', 'Species') :: ['H. pylori', 'Helicobacter pylori']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

answer: @entity19018 :: (CHEBI:32285,Chemical) :: ['[13C]urea']


abstract: Paleoparasitology is the science that uses parasitological techniques for diagnosing @entity4801 in the past. Advances in molecular biology brought new insights into this field allowing the study of archaeological material. However, due to technical limitations a proper diagnosis and confirmation of the presence of parasites is not always possible, especially in scarce and degraded archaeological remains. In this study, we developed a Molecular Paleoparasitological Hybridization (MPH) approach using ancient DNA (aDNA) hybridization to confirm and complement paleoparasitological diagnosis. Eight molecular targets from four helminth parasites were included: Ascaris sp., @entity13857 , @entity14188 , and Strongyloides stercoralis. The MPH analysis using 18th century @entity1 remains from Pra  a XV cemetery ( @entity14189 ), Rio de Janeiro, Brazil, revealed for the first time the presence @entity14188 aDNA (50%) in archaeological sites of Brazil. Besides, the results confirmed @entity13857 and Ascaris sp. infections. The prevalence of @entity281 by Ascaris sp. and @entity14188 increased considerably when @entity7541 was applied. However, a lower aDNA detection of @entity13857 (40%) was observed when compared to the diagnosis by paleoparasitological analysis (70%). Therefore, based on these data, we suggest a combination of Paleoparasitological and MPH approaches to verify the real panorama of @entity11333 in @entity1 archeological samples.

title: Molecular paleoparasitological hybridization approach as effective tool for diagnosing @entity1 XXXX from scarce archaeological remains.

entities_list: @entity11333 :: ('MESH:D007411', 'Disease') :: ['intestinal parasite infection']

entities_list: @entity14188 :: ('51028', 'Species') :: ['Enterobius vermicularis', 'E. vermicularis']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic diseases']

entities_list: @entity13857 :: ('36087', 'Species') :: ['Trichuris trichiura', 'T. trichiura']

answer: @entity11333 :: (MESH:D007411,Disease) :: ['intestinal parasites']


abstract: OBJECTIVES: The aim of this study was to determine the incidence of new or worsened @entity99 after transjugular intrahepatic portosystemic shunts (TIPS) and to ascertain which clinical characteristics are associated with this complication. METHODS: At the University of California, San Francisco, over 22 months, TIPS were placed successfully in 108 adults. Seventy-seven @entity1 in whom it was possible to assess the development of @entity75 comprised the study population. Clinically significant @entity75 was assessed at protocol clinic follow-up and, in some cases, by phone contact with the @entity1 and the referring physician. Post-TIPS @entity75 was defined as new onset of clinical @entity75 requiring treatment or worsening of preexisting @entity75 within 1 yr of TIPS. RESULTS: The overall incidence of new or worsened @entity75 was 23% (18/77). Post-TIPS @entity75 was well controlled with @entity11884 in 78% of cases and was progressive in 22%. Multivariate analysis showed that an increased risk of @entity75 was associated with an etiology of @entity409 other than @entity167 [relative risk (RR) 9.2, p = 0.0052], female gender (RR 3.0, p = 0.029), and @entity4988 (RR 2.2 for each 1 g/dl decrease, p = 0.044). CONCLUSIONS: @entity99 is a common complication of TIPS that can be controlled medically in most @entity1 . The identification of clinical variables associated with an increased risk of @entity75 may be useful in the selection of appropriate candidates for this procedure.

title: XXXX after transjugular intrahepatic portosystemic shunts: incidence and risk factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity11884 :: ('MESH:D007792', 'Chemical') :: ['lactulose']

entities_list: @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy', 'Hepatic encephalopathy']

answer: @entity99 :: (MESH:D056486,Disease) :: ['Hepatic encephalopathy']


abstract: OBJECTIVES: The continued advances in imaging and stent/stent-graft technology have considerably expanded the indications for endovascular approach also in vascular @entity130 . We report our institutional experience with endovascular treatment of peripheral @entity1317 after @entity130 . METHODS: Between January 2000 and June 2006 out of a series of 81 @entity1 , 10 male @entity1 (mean age of 50+/-14 years) with peripheral @entity1317 were managed endovascularly. At admission, @entity548 was present in three @entity1 . Artery location involved common femoral (n=2), subclavian (n=2), axillary (n=2), external iliac (n=2), superficial femoral (n=1), and popliteal (n=1). @entity75 was as follows: @entity2849 (n=4), dissection (n=4), expanding haematoma (n=1), and @entity7838 (n=1). Follow-up program included visit and duplex-ultrasonography, X-rays and/or spiral-computed tomography at 6-month interval during the first year, and yearly thereafter. RESULTS: The lesion was excluded in all cases. All @entity1 survived. Major complications did not occur. Mean hospitalisation was 13 days. Limb-salvage was 100%. Follow-up ranged from 3 to 60 months (mean 16); a late occlusion of a popliteal stent-graft was managed with another endovascular procedure. CONCLUSION: In our experience, endovascular treatment of @entity1317 after @entity130 was feasible and effective.

title: Endovascular treatment for @entity130 of the peripheral arteries following XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic shock']

entities_list: @entity7838 :: ('MESH:D001159', 'Disease') :: ['arterio-venous fistula']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Type of lesion']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injuries', 'arterial injuries']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['blunt trauma']


abstract: BACKGROUND: Aberrations of allelic replication timing are epigenetic markers observed in peripheral blood cells of @entity5 @entity1 . The aberrant markers are non- @entity5 -type-specific and are accompanied by increased levels of sporadic @entity2007 . The study aimed at following the epigenetic markers and @entity2007 levels in cells of @entity1 with haematological @entity5 from diagnosis to full remission, as achieved by allogeneic stem cell transplantation (alloSCT). METHODS: @entity876 (a @entity5 suppressor gene assigned to chromosome 17), @entity5316 (a gene assigned to chromosome 21 and involved in the @entity1778 -abundant 8;21 translocation) and the pericentomeric satellite sequence of chromosome 17 (CEN17) were used for replication timing assessments. Aneuploidy was monitored by enumerating the copy numbers of chromosomes 17 and 21. Replication timing and @entity2007 were detected cytogenetically using fluorescence in situ hybridization (FISH) technology applied to phytohemagglutinin (PHA)-stimulated lymphocytes. RESULTS: We show that aberrant epigenetic markers are detected in @entity1 with @entity1583 from the time of diagnosis through to when they are scheduled to undergo alloSCT. These aberrations are unaffected by the clinical status of the disease and are displayed both during accelerated stages as well as in remission. Yet, these markers are eradicated completely following stem cell transplantation. In contrast, the increased levels of @entity2007 (irreversible genetic alterations) displayed in blood lymphocytes at various stages of disease are not eliminated following transplantation. However, they do not elevate and remain unchanged (stable state). A demethylating anti- @entity5 drug, @entity2591 , applied in vitro to lymphocytes of @entity1 prior to transplantation mimics the effect of transplantation: the epigenetic aberrations disappear while @entity2007 stays unchanged. CONCLUSIONS: The reversible nature of the replication aberrations may serve as potential epigenetic blood markers for evaluating the success of transplant or other treatments and for long-term follow up of the @entity1 who have overcome a @entity1583 .

title: The aberrant asynchronous replication - characterizing lymphocytes of XXXX @entity1 - is erased following stem cell transplantation.

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity2591 :: ('MESH:D001374', 'Chemical') :: ['5-azacytidine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignancies']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies', 'hematological malignancy']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: @entity1499 is a @entity9796 reductase inhibitor with application both as a chemotherapeutic agent and as a disease-modifying antirheumatic drug. Although its ability to inhibit cellular proliferation is a desired effect in its role as an antineoplastic agent, this property may also hinder normal physiologic regeneration of the nasal epithelium. This effect may predispose @entity1 to septal cartilage @entity63 , @entity39 and, eventually, perforation. We report 2 cases of septal perforations in the setting of prolonged @entity1499 use and present a literature review. @entity1 1 is an 8-year-old @entity1 with @entity309 managed with weekly @entity1499 who developed a 4-mm septal perforation with an unremarkable biopsy. This was closed with a mucosal advancement flap without incident. @entity1 2 is an 11-year-old @entity1 with @entity1893 treated with @entity1499 . His examination was significant for a large perforation of the dorsocaudal septum. A biopsy was negative for @entity5 in this @entity1 . Repair has been deferred-initially for chemotherapy and currently for treatment relapse. We hypothesize that prolonged use of @entity1499 alters the balance between physiologic desquamation and epithelial regeneration. This imbalance may promote septal @entity63 and predispose @entity1 to the development of septal perforations.

title: Potential predisposition for nasal septal perforation with XXXX use: report of 2 cases and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'boy']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity9796 :: ('MESH:C010920', 'Chemical') :: ['dihydrofolate']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['Methotrexate', 'methotrexate']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['juvenile rheumatoid arthritis']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: BACKGROUND: Injuries among seniors are recognised as an important public health problem not only in developed countries but also in middle-income countries. There is ample epidemiological literature that relates economic growth to the @entity166 and childhood diseases. Less evidence exists to document if economic growth alone is enough to reverse the increasing trends of @entity130 and morbidity among seniors in a middle-income country. AIM: To investigate the association between economic growth and @entity204 among older @entity1 in Colombia. METHOD: Using data from Colombia, 1979-2006 (n=28), time-series models were used to ascertain if the variation over time in @entity130 among seniors is related to short-term oscillations in economic performance. Four empirical specifications usually used in the analysis of such data were implemented. Models were run by @entity130 and gender. RESULTS: A negative but moderate effect of economic growth was found on @entity204 among older @entity1 . The reported elasticity was between -0.98 and -1.26. @entity1 benefit from economic growth more than @entity1 . Economic growth seems to reduce traffic @entity130 , suicides and homicides. A positive association was also found between falls and growth in gross domestic product. CONCLUSIONS: The results indicate a non-homogeneous association between economic growth and @entity204 among seniors in Colombia. This association is usually stronger in a negative direction among @entity1 and younger adults. Although more research is needed to understand the causal relationship between economic growth and injury, the association found may suggest that economic growth may not be sufficient to reverse @entity204 among older @entity1 ; therefore, additional health policies need to be in place to reduce mortality due to preventable @entity130 in seniors.

title: Association between economic growth and XXXX among seniors in Colombia.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'Men', 'people']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['injury deaths']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['reduction of infectious']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'type of injury', 'injury mortality']

answer: @entity130 :: (MESH:D014947,Disease) :: ['injury mortality']


abstract: OBJECTIVES: In view of evidence that mature cells play a role in modulating the stem cell niche and thereby stem cell potential and proliferation, we hypothesized that a mature bone marrow (BM) mononuclear cell (MNC) infusion subfraction may have particular potency in promoting @entity1583 or resident stem cell-induced cardiac repair post- @entity1188 . BACKGROUND: Treatment of acute @entity583 ( @entity583 ) with BM MNC infusion has shown promise for improving @entity1 outcomes. However, clinical data are conflicting, and demonstrate modest improvements. BM MNCs consist of different subpopulations including stem cells, progenitors, and differentiated leukocytes. METHODS: Stem cells ( @entity17777 +) and subsets of mature cells including myeloid lineage, B and T-cells were isolated from bone marrow harvested from isogeneic donor @entity35 . Recipient @entity35 had baseline echocardiography then coronary artery ligation; 1 x 10(6) cells (enriched subpopulations or combinations of subpopulations of BM MNC) or saline was injected into @entity63 and @entity63 border zones. Cell subpopulations were either injected fresh or after overnight culture. After 2 weeks, animals underwent follow-up echocardiography. Cardiac tissue was assayed for cardiomyocyte proliferation and apoptosis. RESULTS: Fractional ventricular diameter shortening was significantly improved compared with saline ( @entity19 .2%) when B cells alone were injected fresh (44 +/- 3.0%, p = 0.035), or after overnight culture (51 +/- 2.9%, p < 0.001), or after culture with @entity17777 + cells (44 +/- 2.4%, p = 0.062). B cells reduced apoptosis at 48 h after injection compared with control cells (5.7 +/- 1.2% vs. 12.6 +/- 2.0%, p = 0.005). CONCLUSIONS: Intramyocardial injection of B cells into early post- @entity63 myocardium preserved cardiac function by cardiomyocyte salvage. Other BM MNC subtypes were either ineffective or suppressed cardioprotection conferred by an enriched B cell population.

title: Bone marrow-derived B cells preserve ventricular function after acute XXXX .

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: The aim of this study was to evaluate the radiosensitizing effects of @entity136 towards @entity1 @entity788 xenografts. A @entity1 @entity788 xenograft model was established in @entity19 , 36 of which were randomly divided into 6 treatment groups. @entity5 were measured every 2 days, and the @entity5 volumes, growth delays, and inhibition rates were compared to evaluate the @entity136 enhancement factor. The apoptotic index was determined by terminal deoxynucleotidyl transferase @entity1977 nick end-labeling assay, and apoptosis inhibitory protein @entity588 and apoptosis-related protein @entity589 expression were detected by immunohistochemistry. Compared with the control group, xenograft growth was significantly inhibited in the 25 (G25) and 50 mg/kg @entity136 (G50) groups (P < 0.05). In the 25 ( @entity4983 ) and 50 ( @entity4984 ) mg/kg @entity136 + radiotherapy groups, local @entity5 growth was significantly inhibited, with inhibition rates of 88.22 and 91.23%, respectively, significantly higher than those of the simple radiotherapy (SR), G25, and G50 groups (44.11, 72.88, and 77.53%, respectively; P < 0.05). The @entity5 growth delay in the @entity4983 and @entity4984 groups were 9 and 15 days, respectively, higher than the SR, G25, and G50 groups (each 4 days, P < 0.05). The apoptosis of @entity5 cells in the intervention groups significantly increased, and the apoptotic index among the intervention groups exhibited significant differences (P < 0.05). The immunohistochemical results indicated that @entity588 was downregulated to different degrees in the intervention groups, whereas @entity589 was upregulated (P < 0.05). Therefore, @entity136 appears to enhance the radiotherapeutic sensitivity of @entity1 @entity788 xenografts significantly.

title: Effects of @entity136 on radiosensitization, apoptosis, and @entity588 and XXXX protein expression in @entity1 @entity788 xenografts in @entity19 .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

entities_list: @entity4984 :: ('p|SUB|G|50|R', 'ProteinMutation') :: ['G50R']

entities_list: @entity4983 :: ('p|SUB|G|25|R', 'ProteinMutation') :: ['G25R']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity589 :: (581,Gene) :: ['Bax']


abstract: BACKGROUND/AIMS: Gene-dietary pattern interactions may contribute to the determination of a susceptibility to @entity209 ( @entity209 ). The aim of this study was to evaluate the potential interactions of dietary patterns with the common genetic variant of @entity12436 in relation to @entity209 in adults. METHODS: In this individual matched nested case-control study, 755 @entity209 subjects and 755 controls were selected from among @entity1 in the Tehran Lipid and @entity413 Study. Dietary patterns were determined by factor analysis. @entity12436 @entity15186 r @entity15187 was genotyped by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: Fat-sweet, healthy and Western dietary patterns (WDP) were extracted from the data. In the joint analysis, the associations of the WDP and A @entity12436 r @entity15187 with M @entity209 risk tended to be dependent on A @entity12436 3 @entity15186 gene variants (p for interaction = 0.009) in w @entity1 The M @entity209 risk was increased in w @entity1 with the CC genotype with increasing tertiles of WDP scores compared with w @entity1 with the CG + GG genotype, whose M @entity209 risk was decreased with increasing tertiles of WDP scores. In addition, we found that intakes of fast food, salty snacks and soft drinks showed significant interactions with the r @entity15187 genotypes in relation to M @entity209 risk (p for interactions <0.05). CONCLUSION: The results obtained demonstrate a diet-gene interaction between A @entity12436 r @entity15187 polymorphism and the WDP in relation to M @entity209 risk.    2014 S. Karger AG, Basel.

title: Western Dietary Pattern Interaction with XXXX Polymorphism in the Risk of Metabolic Syndrome: Tehran Lipid and @entity413 Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'MetS']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['Glucose']

answer: @entity12436 :: (345,Gene) :: ['APOC3']


abstract: BACKGROUND: @entity1 whose parents have @entity5 are at risk for psychosocial difficulties; however, the mechanisms are not well understood. This cross-sectional study sought support for a model connecting parental @entity5 to @entity1 distress through its impact on parenting self-efficacy beliefs and parenting behaviors by examining relations among @entity6160 , quality of life/parent functioning, parenting efficacy beliefs, and concerns about @entity1 's emotional distress. METHODS: One hundred ninety-four adult oncology outpatients with @entity1 who were 18 years old or younger completed questionnaires assessing their health-related quality of life (Functional Assessment of @entity5 Therapy-General), @entity308 and @entity148 ( @entity148 and @entity308 Scale), overall distress ( @entity147 Thermometer), and parenting efficacy beliefs and parenting concerns (Parenting Concerns Questionnaire). RESULTS: Parenting efficacy scores for parents and coparents declined significantly after diagnosis. This decline correlated with more visits to a medical clinic, treatment with intravenous chemotherapy in the past month, poorer health-related quality of life, and more @entity308 and distress. Parents experiencing the most concern about the impact of mood, physical limitations, and changes in routines on their @entity1 experienced the biggest declines in their own sense of efficacy as parents and in their belief in their coparent's efficacy. Finally, declines in parenting efficacy beliefs correlated with parental concerns about @entity1 's emotional distress about aspects of the parent's illness. CONCLUSIONS: This study highlights the importance of identifying and addressing parenting concerns to alleviate @entity1 distress, and it may help to guide future intervention efforts. @entity5 2015;121:3435-43.    2015 American @entity5 Society.

title: Parenting changes in adults with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'patient', 'child']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity6160 :: ('MESH:D063129', 'Disease') :: ['parental illness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity147 :: ('MESH:D005316', 'Disease') :: ['Distress']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'Hospital Anxiety']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND AND PURPOSE: It is unclear whether acute @entity385 exhibits a seasonal pattern in Japan. The aim of the present study was to elucidate seasonal differences in acute @entity385 . METHODS: Our study enrolled 12,660 @entity1 with @entity385 (7943 @entity1 , 4717 @entity1 ; mean age, 70.1 years, S.D. 11.5; median 70; range 18-107). We divided the year into four parts: spring (March-May); summer (June-August); fall (September-November); and winter (December-February). Time of @entity64 onset was divided into three subgroups: daytime (08:00-16:00), evening (16:00-24:00), and night (24:00-08:00). We examined the association between clinical characteristics, season, and time of @entity64 onset. RESULTS: @entity64 occurred least frequently in spring (22.9%), followed by winter (25.3%), fall (25.8%), and summer (26.0%) (P<0.001). No differences in age, National Institutes of Health @entity64 Scale (NIHSS) score, modified Rankin Scale (m-RS) score, history of @entity385 ( @entity385 ), or risk factors for @entity64 were observed among the four seasons. @entity64 in @entity1 (63.8% vs. 62.4%; P<0.01), @entity64 ( @entity64 ) (41.2% vs. 39.4%, P<0.01), @entity64 ( @entity64 ) (34.0% vs. 32.3%; P<0.01), and nighttime @entity64 (26.5% vs. 24.8%; P<0.05) were observed more frequently in summer compared to other seasons. This contrasts with the findings for @entity64 in @entity1 (39.0% vs. 36.7%; P<0.05), @entity64 ( @entity64 ) (23.4% vs. 20.6%; P<0.05), and daytime @entity64 (47.4% vs. 45.0%; P<0.05), which were more frequent in winter. CONCLUSIONS: Acute @entity385 displays seasonal characteristics according to gender, @entity64 subtype, and time of @entity64 onset. These results may have important clinical implications in @entity385 prevention.

title: Variation in XXXX frequency in Japan by season and by other variables.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['lacunar stroke', 'CES', 'atherothrombotic stroke', 'ATS', 'cardioembolic stroke', 'stroke', 'LS', 'Stroke']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['stroke/transient ischemic attack', 'ischemic stroke', 'TIA']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: BACKGROUND: Controversies surround a diagnosis of @entity6 ( @entity6 ). The objective of this study was to evaluate the oral @entity413 tolerance test (OGTT) for the prediction of adverse gestational and perinatal outcomes in pregnant @entity1 with a positive screening test for @entity6 and a negative diagnosis, i.e. a normal 3-hour OGTT. METHODS: This validation study evaluated 409 pregnant @entity1 who tested positive for @entity6 at screening. Perinatal and maternal outcomes were considered. Sensitivity and specificity were calculated for each of the values of the OGTT as a diagnostic test, with the gold standard being perinatal outcome. RESULTS: The most frequent risk factors were @entity28 , arterial @entity101 and advanced maternal age. The most common neonatal outcomes were large-for-gestational-age @entity1 , Cesarean delivery and preterm birth. A fasting blood @entity413 level of 87 mg/dL was the most powerful predictor of adverse perinatal outcome. CONCLUSIONS: At the cut-off level adopted by the American @entity6 Association, gestational OGTT was able to successfully identify in which pregnant @entity1 outcome would be unfavorable.

title: The prognostic value of a normal oral XXXX tolerance test in pregnant @entity1 who tested positive at screening: a validation study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'infants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'gestational diabetes mellitus', 'diabetes mellitus', 'GDM']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: In the years from 1948 to 1977, 359 @entity1 with simple or complicated reflux disease of the oesophagus (RDOe) and/or the hiatushernia complex were operated on at the 1st Clinic of Surgery of the Medical Faculty, Palack   University in Olomouc. The authors found the following frequency of occurrence of the fundamental symptoms: (1) In simple RDOe, pyrosis in 82%, @entity158 in 82% (epigastrium 42%, thorax 30%, throat 7%), a @entity73 in 50%, regurgitation in 30%, @entity391 in 15%, ructus and @entity1282 in 11%. The median time of the anamnesis was 5.6 years. --(2) In the complicated RDOe, the most frequent symptoms were @entity1282 in 78%, pyrosis in 62%, @entity158 in 39%, loss of weight in 33%, and regurgitation in 28%. The median time of the anamnesis was 2.5 years. Only in 20% of the @entity1 , a longer anamnesis of the subjective complaints was recorded. --(3) In cases of @entity547 , the fundamental symptom was @entity158 --in the epigastrium in 62% and retrosternally in 38%. There followed @entity391 in 38%. Quite asymptomatical was the course of the disease in 12% of the @entity1 . The median time of the anamnesis was 2 years. --(4) In the mixed form of @entity357 , the gastro-eosophageal reflux was preoperatively present in 46%; this was consistent with the symptomatology. Coincidence of the RDOe with @entity2963 was found in 20% and in combination with a duodenal ulcus in 11% of the cases. These two forms of the disease are now mostly treated with the antireflux operation. In cases of an ulcus duodeni, superselective vagotomy and fundoplicatio according to Nissen-Rossetti are the methods of choice. --In 5% of the @entity1 , the development of the reflux symptomatology had been preceded by a stomach resection. In 4 @entity1 with @entity850 , the interval between the operation and the @entity850 was very short (1 to 12 weeks).

title: [Clinical picture and differential diagnosis of esophageal reflux and XXXX complex].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['postural impairment']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['hiatus hernias']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['paraoesophageal hernias']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['reflux stenosis', 'stenosis']

answer: @entity357 :: (MESH:D006551,Disease) :: ['hiatal hernia']


abstract: UNASSIGNED: Study Design Case report. Background Common complications from abdominal and pelvic surgery include adhesions and @entity1118 . Laparoscopic adhesiolysis is sometimes used with the intent of reducing adhesions and related @entity158 . Physical therapy interventions, such as soft tissue mobilization (STM) may be used for this condition, but evidence to support its effectiveness is lacking. Case Description A 28-year-old female with a history of 5 abdominal/pelvic surgeries presented with right-sided lower abdominal and anterior @entity158 present since laparoscopic appendectomy with a right ovarian cystectomy surgery performed 1 year earlier. She was an active duty member in the United States Navy, and due to @entity158 and @entity425 , was unable to perform required curl-ups for her fitness test. She had been previously treated both surgically with laparoscopy adhesiolysis and non-surgically with physical therapy consisting of stretching and strengthening exercises; however, her @entity158 and function did not improve. She was again evaluated and treated by physical therapy; and based on her examination findings, STM was used to address her @entity158 and dysfunction presumably related to @entity1320 . Outcomes Following 5 sessions of physical therapy, over a 3 week period, which included STM and therapeutic exercises, followed by 5 additional sessions, over a 4 week period, which focused on therapeutic exercises, the @entity1 reported substantially decreased @entity158 , improved function, and a full return to previous level of activity, including unrestricted physical training in a military setting. Discussion The outcomes on this @entity1 suggest STM as a conservative treatment option for @entity158 and dysfunction presumed related to @entity1320 from abdominal/pelvic surgeries. Higher level of evidence studies, including potential comparison between STM to traditional laparoscopic adhesiolysis are needed to further determine benefits of non-surgical care for this condition. Level of Evidence Therapy, level 4. J Orthop Sports Phys Ther, Epub 15 Oct 2015. doi:10.2519/jospt.2015.5766.

title: Soft Tissue Mobilization to Resolve XXXX and Dysfunction Associated With Post-Operative Abdominal and Pelvic Adhesions: A Case Report.

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['hip pain', 'pain']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal adhesions']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['Chronic Pain']


abstract: Pedicel length and orientation (angle) contribute to the diversity of inflorescence architecture, and are important for optimal positioning of the flowers. However, relatively little is known about pedicel development. We previously described the @entity958 @entity16470 ( @entity16470 )/BIG gene, which affects inflorescence architecture by controlling pedicel elongation and orientation. Here, we performed a suppressor screen using the partial loss-of-function allele @entity16470 -13 to identify genes and pathways that affect pedicel development. We identified a hypomorph allele of the meristem identity regulator @entity16471 (LFY) as the suppressor. Consistent with this, @entity16470 pedicels had elevated LFY levels and conditional gain of LFY function produced downward-bending pedicels. @entity134 activation of 35S:LFY-GR plants caused a reduction in the cortical cell length in the abaxial domain and additional defects associated with adaxialization. Further analyses of loss of LFY function revealed that LFY is required for reduced cortical cell elongation at the adaxial side of the pedicel base. Defects in conditional LFY gain-of-function pedicels were correlated with decreased @entity13108 ( @entity13108 ) expression, while @entity6267 ( @entity6267 ), a transcriptional repressor of @entity13108 , and REVOLUTA, a promoter of adaxial cell fate, were highly and ectopically expressed in LFY gain-of-function pedicels. LFY bound to cis-regulatory regions upstream of @entity6267 , and @entity6267 mutations partially suppressed the pedicel length and orientation defects caused by increased LFY activity. These data suggest that LFY activity promotes adaxial cell fate and hence the proper orientation and length of the pedicel partly by directly activating @entity6267 expression, which suppresses @entity13108 expression.

title: @entity16471 controls XXXX pedicel length and orientation by affecting adaxial-abaxial cell fate.

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['Steroid']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis']


abstract: T cells of an unique phenotype ( @entity5168 + @entity1961 -CD8- alpha beta TCR+) develop in vitro from the hematopoietic progenitors, the majority of which carry homologous alpha beta TCR (V alpha 4J alpha 28/V beta 2D beta 1.1J @entity8042 .6). In the present study, antigen corresponding to the particular alpha beta TCR was investigated, taking advantage of the fact that growth of T cell hybridomas was arrested by their TCR stimulation. Results indicated that both syngeneic and allogeneic thymocytes, particularly from newborn @entity19 , could specifically inhibit the proliferation of a T cell hybridoma with the V alpha 4/V @entity8042 TCR (15H1.2). Proliferation of neither TCR-missing hybridoma subclones nor those with unrelated alpha beta TCRs was affected at all. It was also found that @entity189 ( @entity189 ) cells without classical MHC antigens could specifically inhibit the proliferation of 15H1.2 cells. We then raised a mAb, 14.37, against an @entity189 line, @entity18761 , that could interfere with the ability of them to inhibit the growth of 15H1.2. Pretreatment of 15H1.2 cells with anti-V @entity8042 and @entity18761 cells with 14.37 mAb respectively completely abrogated the growth inhibition of 15H1.2 by @entity18761 . The 14.37 antigen was a 120 kDa heterodimer glycoprotein consisting of 85 and 36 kDa proteins. In normal lymphoid tissues, the expression of 14.37 antigen exhibited an apparently inverse relationship with that of class I MHC antigens. Thus, ontogenically it was strongly expressed in fetal and newborn @entity19 , rather rapidly declined thereafter, and remained at very low levels in adult organs. In a given stage, the distribution of 14.37 antigen and class I MHC was rather exclusive to each other.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Involvement of 4F2 antigen expressed on the MHC-negative target cells in the recognition of @entity19 XXXX + @entity1961 -CD8- alpha beta (V alpha 4/V @entity8042 ) T cells.

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['embryonal carcinoma', 'EC']

answer: @entity5168 :: (12501(Tax:10090),Gene) :: ['CD3']


abstract: The purpose of this study was to describe the mechanism and determine predictive factors of mitral @entity397 requiring valve replacement following percutaneous mitral commissurotomy. Of the 350 consecutive @entity1 treated by balloon mitral commissurotomy, the procedure was not completed in 16, and 11 developed acute severe @entity339 requiring valve replacement: seven cases of anterior leaflet @entity397 , three cases of posterior leaflet @entity397 and one case of anterior chordal surface. These 27 group I @entity1 were compared to the remaining 323 (group II) in whom the procedure was completed. The 11 excised valves were evaluated by an experienced pathologist. Eight of the 11 @entity1 had an echocardiographic score < 8 (mean score 6.5 +/- 1), no valvular calcification at X-ray and double balloon percutaneous mitral commissurotomy. Microscopy in six @entity1 showed focal fibrous thickening at the site of the @entity397 but no calcification. One @entity1 developed severe @entity339 due to @entity397 with an Inoue balloon. The two remaining @entity1 had an echo score of ten and valve calcification on X-ray. Microscopy revealed severe homogeneous chronic @entity627 . In one of these two @entity1 , leaflet @entity397 was related to an 'oversized balloon' (2 x 19 mm + 15 mm). Statistical analysis showed only echo score differences between the two groups (6.9 +/- 1.4 in group I vs 8.2 +/- 1.6 in group II, P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Mitral XXXX following percutaneous mitral commissurotomy: existence of predictive factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic mitral disease']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['valve rupture', 'chordal rupture', 'rupture']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral regurgitation']

answer: @entity397 :: (MESH:D012421,Disease) :: ['valve rupture']


abstract: PURPOSE: @entity5825 ( @entity5825 ) is a common @entity1800 in @entity1 , which is usually mild and self-limiting. However, in recent epidemics of @entity5825 in Asia, enterovirus 71 (EV71) has been recognized as a causative agent with severe @entity16 with or without cardiopulmonary involvement. @entity5825 was epidemic in Korea in the spring of 2009. Severe cases with complications including @entity204 have been reported. The clinical characteristics in @entity1 with neurologic manifestations of EV71 were studied in Ewha Womans University Mokdong Hospital. METHODS: Examinations for EV71 were performed from the stools, respiratory secretion or CSF of @entity1 who presented @entity16 associated with @entity5825 by realtime PCR. Clinical and radiologic data of the @entity1 were collected and analyzed. RESULTS: EV71 was isolated from the stool of 16 @entity1 but not from respiratory secretion or CSF. Among the 16 @entity1 , @entity693 (n=10) was the most common manifestation, followed by @entity5011 (n=3), @entity5422 (n=2), @entity3328 -like @entity66 (n=1), and @entity2045 (n=1). Gene analysis showed that most of them were caused by EV71 subgenotype C4a, which was prevalent in China in 2008. CONCLUSION: Because EV71 causes severe complications and @entity204 in @entity1 , a surveillance system to predict upcoming outbreaks should be established and maintained and adequate public health measures are needed to control disease.

title: Enterovirus 71-associated hand, foot and mouth diseases with XXXX , a university hospital experience in Korea, 2009.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity3328 :: ('MESH:D011051', 'Disease') :: ['poliomyelitis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['paralytic disease']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonus']

entities_list: @entity5422 :: ('MESH:D008590', 'Disease') :: ['meningoencephalitis']

entities_list: @entity5825 :: ('MESH:D006232', 'Disease') :: ['HFMD', 'Hand-foot-mouth disease']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic symptoms', 'neurological symptoms']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral illness']

entities_list: @entity5011 :: ('MESH:D020275', 'Disease') :: ['Guillain-Barr   syndrome']

answer: @entity16 :: (MESH:D009422,Disease) :: ['neurologic symptoms']