abstract: @entity28 has been associated with several @entity102 , such as @entity301 , @entity64 , adverse pregnancy outcomes, @entity6 , and mortality; however it has not been until recently that an increased body mass index (BMI) was also related to @entity4500 , especially @entity2521 . We conducted a research to determine whether oral health was related to BMI using a cross-sectional design. Of 320 non-smoking subjects aged 31-60 years recruited from the @entity1 referred to Dental Clinic at the Clinical Hospital Center in Rijeka, Croatia, a detailed @entity4500 status was completed for 292 subjects. Measurements of weight and height, education level and frequency of toothbrushing were also recorded. Dental index comprising information on caries, @entity2521 , @entity1548 , and missing teeth was used as a measure of @entity4500 . Dental index and education level both correlated significantly with BMI, however for the dental index this correlation was rather weak. The same could not be proven for the frequency of tooth brushing. Multivariate linear analysis showed that BMI was most dependent upon the number of missing teeth (88.6%), followed by the number of @entity1547 (8.3%). @entity1 with an increased BMI had slightly worse @entity4500 , as represented by higher dental index, regardless of their toothbrushing routines, and lower levels of education. Prevention programs should aim at rising both the general health awareness and improving oral health.

title: XXXX and oral health--is there an association?

entities_list: @entity1 :: ('9606', 'Species') :: ['Persons', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity1548 :: ('MESH:D010483', 'Disease') :: ['periapical lesions']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

entities_list: @entity1547 :: ('MESH:D003731', 'Disease') :: ['carious lesions']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

entities_list: @entity4500 :: ('MESH:D014071', 'Disease') :: ['dental health']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Obesity']


abstract: BACKGROUND: Forefoot adduction is the most common @entity85 in the treatment of pediatric @entity5149 . Little documentation exists regarding its late occurrence and early detection. A retrospective analysis was conducted to determine the effect of primary posterior medial release for idiopathic @entity5149 that had failed to improve with conservative treatment or had presented after a treatment delay and a subsequent forefoot adduction correction with a cuboid-cuneiform osteotomy. METHODS: Radiographic evaluations were conducted of all of the surgical procedures performed at our institution for idiopathic @entity5149 during a specified period. Preoperative and postoperative talo-first metatarsal and talocalcaneal angles were measured radiographically. Of 138 @entity1 with @entity85 who met the inclusion criteria, 51 underwent a primary posterior medial release; of these @entity1 , 18 (26 feet) underwent a subsequent cuboid-cuneiform osteotomy. RESULTS: The average preoperative and postoperative talo-first metatarsal anteroposterior angles for @entity1 who underwent primary posterior medial release were 44.6 degrees and 26.8 degrees , respectively. The mean reduction in forefoot adduction was 17.8 degrees (P < .05). After the osteotomy, the average talo-first metatarsal anteroposterior angle was 16 degrees , with an average reduction of 10.8 degrees (P < .05). Mean follow-up was 61.2 months. The average @entity1 age was 3.2 years. CONCLUSIONS: Eighteen (35%) of 51 @entity1 who underwent a posterior medial release required a subsequent cuboid-cuneiform osteotomy. The average reduction of 10.8 degrees was statistically significant and has also proved to be clinically significant in the overall correction of the deformity.

title: Forefoot adductus correction in XXXX with cuboid-cuneiform osteotomy: a retrospective analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['residual deformity', 'clubfoot deformity']

answer: @entity85 :: (MESH:D009140,Disease) :: ['clubfoot deformity']


abstract: The response of @entity797 @entity797 to salt stress has been characterized previously in complex media. In this report, it has been demonstrated that this bacterium actively accumulates the osmoprotectant @entity2228 betaine (GB) from salt-enriched complex medium BHI. To further understand the specific effects of GB and other osmoprotective compounds in salt adaptation and salt-induced cross-tolerance to lethal challenges, a chemically defined medium lacking putative osmoprotectants was used. In this medium, bacterial growth was significantly reduced by increasing concentrations of @entity1219 . At 0.75 M @entity1219 , 90% inhibition of the growth rate was observed; GB and its structural analogues restored growth to the non-salt-stressed level. In contrast, @entity1521 , @entity37855 and @entity31786 did not allow growth recovery of stressed cells. Kinetic studies showed that the uptake of betaines shows strong structural specificity and occurs through a salt-stress-inducible high-affinity porter [Km = 3.3 microM; Vmax = 130 nmol min(-1) (mg protein)(-1); the uptake activity increased 400-fold in the presence of 0.5 M @entity1219 ]. Moreover, GB and its analogues were accumulated as non-metabolizable cytosolic osmolytes and reached intracellular levels ranging from 1-3 to 1.5 micromol (mg protein)(-1). In contrast to the beneficial effect of GB on the growth of salt-stressed cultures of @entity797 , its accumulation inhibits the salt-induced cross-tolerance to a heterologous lethal challenge. Indeed, pretreatment of bacterial cells with 0.5 M @entity1219 induced resistance to 0.3% @entity3645 (survival of adapted cells increased by a factor of 6800). The presence of GB in the adaptation medium reduced the acquisition of @entity3645 resistance 680-fold. The synthesis of 11 of the 13 proteins induced during salt adaptation was significantly reduced in the presence of GB. These results raise questions about the actual beneficial effect of GB in natural environments where bacteria are often subjected to various stresses.

title: The osmoprotectant @entity2228 betaine inhibits salt-induced cross-tolerance towards lethal treatment in XXXX .

entities_list: @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']

entities_list: @entity37855 :: ('CHEBI:36110', 'Chemical') :: ['pipecolate']

entities_list: @entity797 :: ('1351', 'Species') :: ['ATCC 19433', 'Enterococcus faecalis', 'E. faecalis']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity3645 :: ('MESH:D001647', 'Chemical') :: ['bile salts']

answer: @entity797 :: (1351,Species) :: ['Enterococcus faecalis']


abstract: @entity159 ( @entity159 ) is a medical emergency weighed by a relevant morbidity and mortality. It mainly affects @entity1 with primary or secondary @entity3519 and is often triggered by events such as fever, @entity281 , exposure medications or their abrupt cessation. We report on three @entity1 presenting with @entity159 . Two of them were affected by a static @entity75 and the other one by a @entity179 such as @entity10389 ( @entity10389 ). To our knowledge this is the first @entity1 affected by @entity10389 presenting with @entity159 . All our @entity1 underwent continuous infusion of @entity1363 , in association with @entity1766 and @entity20286 , which led to complete resolution of muscular @entity2473 in two @entity1 . In the other one a complete cessation of @entity3520 was obtained after intrathecal @entity1772 . From a therapeutic point of view there are no evidence-based management guidelines in @entity159 . The approach is empiric and based on very limited anecdotal reports. On the basis of our observations and an extensive review of the literature we delineated a possible therapeutic strategy of @entity159 in @entity1 .

title: Management of status dystonicus in XXXX . Cases report and review.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1766 :: ('MESH:D010868', 'Chemical') :: ['pimozide']

entities_list: @entity3520 :: ('MESH:D020821', 'Disease') :: ['dystonic spasms']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity10389 :: ('MESH:C536141', 'Disease') :: ['megalencephalic leukoencephalopathy with subcortical cysts', 'MLC']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder']

entities_list: @entity1772 :: ('MESH:D001418', 'Chemical') :: ['baclofen']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['SD', 'Status dystonicus']

entities_list: @entity20286 :: ('MESH:D014282', 'Chemical') :: ['trihexyphenidyl']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: In @entity2621 ( @entity2621 ), there is evidence for activation of peripheral T-lymphocytes that predominantly express a T helper 1 (T(H)1) cytokine bias. However, the immunomodulatory factors involved in regulating this response have so far received scant attention. In this study, we examine the effects of the glucocorticoid, @entity619 , and the @entity6864 ( @entity6864 ) ligand, @entity6170 on the expression of @entity379 (T(H)1) and @entity3646 (T(H)2) by activated peripheral @entity404 (+) and @entity405 (+) lymphocytes in @entity1 with @entity2621 (n = 10) and healthy control subjects (n = 12). METHODS: Peripheral blood mononuclear cells (PBMC) were stimulated in vitro with @entity4514 ( @entity4515 ) and @entity1360 in the presence or absence of varying doses of @entity619 and @entity6170 (0.01 microM, 1.0 microM, and 100 microM). Cytokine expression was determined by flow cytometry. RESULTS: @entity404 expression was greater in @entity2621 than controls (14.87 versus 9.25; p < 0.05 and 21.34 versus 10.16; p < 0.01, respectively). A dose-dependent inhibition of @entity379 expression was seen with @entity619 and @entity6170 . Inhibition of @entity404 expression with both @entity619 and @entity6170 was greater in control subjects than in @entity1 (p < 0.05). There was no significant difference in @entity3646 expression between @entity1 and control groups and its expression remained unaffected by either compound. CONCLUSIONS: We show that @entity404 (+) and @entity405 (+) T lymphocytes from @entity2621 @entity1 express a type 1 cytokine bias that is significantly more resistant to in vitro modulation by @entity6170 and @entity619 . Further studies are needed to clarify if this resistance plays a role in the pathogenesis of @entity1669 ( @entity1669 ).

title: Peripheral cytokine expression in XXXX : effects of in vitro modulation by @entity6170 and @entity619 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2621 :: ('MESH:D050031', 'Disease') :: ["Hashimoto's thyroiditis", 'HT']

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease', 'AITD']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1360 :: ('MESH:D015759', 'Chemical') :: ['ionomycin']

entities_list: @entity379 :: ('3458', 'Gene') :: ['interferon (IFN)-gamma', 'IFN-gamma']

entities_list: @entity4514 :: ('MESH:D013755', 'Chemical') :: ['phorbolmyristate acetate']

entities_list: @entity6170 :: ('MESH:C089730', 'Chemical') :: ['rosiglitazone']

entities_list: @entity6864 :: ('5468', 'Gene') :: ['peroxisome proliferator-activated receptor-gamma', 'PPAR-gamma']

answer: @entity1669 :: (MESH:D013967,Disease) :: ['autoimmune thyroiditis']


abstract: BACKGROUND: The incidence of @entity263 is much lower in Asian @entity1 than in Western @entity1 . This study investigated whether @entity263 is associated with @entity1069 , @entity1067 ( @entity1067 ), and other medical conditions in the low-incidence population. METHODS: From the claims data obtained from the universal National Health Insurance of Taiwan, we identified 1184 @entity1 with @entity263 diagnosed from 1997 to 2008. Controls comprised 4736 @entity1 randomly selected from a @entity5 . Both groups were 50 years of age or above. Medical histories between the two groups were compared. RESULTS: Multivariate logistic regression analysis showed that @entity1069 and @entity1067 had stronger association with @entity263 than the other medical conditions tested. Compared with @entity1 without @entity1069 and @entity1067 , a higher odds ratio (OR) for @entity263 was associated with @entity1067 (26.2, 95% confidence interval (CI) 20.8-33.0) than with @entity1069 (10.5, 95% CI=3.36-32.7). @entity1 with both conditions had an OR of 49.2 (95% CI=34.7-69.9). CONCLUSION: @entity1 with @entity263 have strong association with @entity1069 and/or @entity1067 . @entity1069 interacts with @entity1067 , resulting in higher estimated relative risk of @entity263 in @entity1 suffering from both conditions.

title: Synergistic interaction of @entity1067 and @entity1069 on XXXX risk.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men']

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['Prostatitis', 'prostatitis']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-free population']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: To assess the comparable efficacy and adverse effect profile of two extended-release preparations of @entity594 --gastrointestinal therapeutic system (GITS) and coat-core (CC)--in @entity1 with mild-to-moderate @entity101 . DESIGN: Single institution, single-blind, prospective study. SETTING: Dwight David Eisenhower Army Medical Center, Fort Gordon, GA. @entity1 : Ninety-one @entity1 who were taking @entity594 GITS as a sole antihypertensive agent were randomized to receive either GITS or CC. After 3 weeks, 24-hour ambulatory blood pressure monitoring was conducted and an adverse effect questionnaire was administered. The @entity1 were then crossed over to the other treatment arm and monitoring was repeated after 3 weeks. MEASUREMENTS: Mean blood pressure, heart rates, and the percentage of readings exceeding 140 mm Hg systolic and 90 mm Hg diastolic were compared for the 24-hour period. Additionally, mean blood pressures at 4-hour intervals after drug administration and heart rate during the first 8 hours of the dosage interval were compared. RESULTS: Ninety-one @entity1 enrolled, 79 completed the study, and 62 @entity1 were included in the efficacy analysis. A statistically significant difference (p = 0.020) was shown only in the last 4-hour systolic blood pressure. However, this difference was small (122 +/- 15 mm Hg with GITS vs. 126 +/- 14 mm Hg with CC). There was no difference in the percentage of readings exceeding 140 mm Hg systolic or 90 mm Hg diastolic. Neither dosage nor treatment order had an effect on the results. Adverse effects were reported with a greater frequency during CC therapy (40 with CC vs. 22 with GITS; p = 0.006), but were generally transient. Discontinuation of the drug was necessary in 3 @entity1 during the CC cycle. CONCLUSIONS: GITS and CC demonstrated clinically equivalent antihypertensive efficacy in the study population. The CC produce may have a higher rate of adverse effects, but drug discontinuation was uncommon.

title: @entity594 gastrointestinal therapeutic system versus XXXX coat-core: comparison of efficacy via 24-hour ambulatory blood pressure monitoring.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine']

answer: @entity594 :: (MESH:D009543,Chemical) :: ['nifedipine']


abstract: BACKGROUND: It remains unclear whether there are differences in the safety and efficacy outcomes between @entity2239 -eluting stents (EES) and @entity3446 -eluting stents (SES) in contemporary practice. METHODS AND RESULTS: We prospectively enrolled 6166 consecutive @entity1 who received EES (3081 @entity1 ) and SES (3085 @entity1 ) between April 2008 and June 2010, using data from the Interventional Cardiology Research In-Cooperation Society-Drug-Eluting Stents Registry. The primary end point was a composite of @entity204 , nonfatal @entity583 ( @entity583 ), or target-vessel revascularization (TVR). At 2 years of follow-up, the 2 study groups did not differ significantly in crude risk of the primary end point (12.1% for EES versus 12.4% for SES; HR, 0.97; 95% CI, 0.84-1.12, P=0.66). After adjustment for differences in baseline risk factors, the adjusted risk for the primary end point remained similar for the 2 stent types (HR, 0.96; 95% CI, 0.82-1.12, P=0.60). There were also no differences between the stent groups in the adjusted risks of the individual component of @entity204 (HR, 0.93; 95% CI, 0.67-1.30, P=0.68), @entity583 (HR, 0.97; 95% CI, 0.79-1.18, P=0.74), and TVR (HR, 1.10; 95% CI, 0.82-1.49, P=0.51). The adjusted risk of stent @entity715 also was similar (HR, 1.16; 95% CI, 0.47-2.84, P=0.75). CONCLUSIONS: In contemporary practice of percutaneous coronary intervention procedures, the unrestricted use of EES and SES showed similar rates of safety and efficacy outcomes with regard to @entity204 , @entity583 , sent @entity715 , and TVR. Future longer-term follow-up is needed to better define the relative benefits of these drug-eluting stents. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01070420.

title: Outcomes after unrestricted use of @entity2239 -eluting and XXXX -eluting stents in routine clinical practice: a multicenter, prospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2239 :: ('MESH:C107135', 'Chemical') :: ['everolimus']

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity3446 :: (MESH:D020123,Chemical) :: ['sirolimus']


abstract: Radiation therapy is one of the most important modalities for the treatment of @entity2 . Current progress of radiation therapy in cooperation with the development of physics and biology is remarkable. The techniques of three-dimensional treatment planning and three-dimensional conformal radiotherapy (3D-CRT) have facilitated the use of higher radiation doses. @entity1 with early-stage @entity1149 ( @entity1149 ) are candidates for curative surgical resection. However, the number of elderly @entity1 has been increasing, and these @entity1 often have medical contraindications that prevent curative surgery. Recently, several clinical trials on stereotactic body radiotherapy (SBRT) using the 3D-CRT technique for solitary @entity2 have been reported. The local control rate for stage I disease is more than 90%, and survival rates are promising. Now a prospective multi-institutional trial is ongoing to determine whether this modality can become a standard treatment for inoperable @entity1 or an alternative to lobetectomy. For locally advanced @entity1149 , unfortunately, recent studies have demonstrated that conventional therapies may have reached a therapeutic plateau. Now several radiation dose escalation studies utilizing conventional fractionation and 3D-CRT techniques are ongoing. The strategies of almost all of these trials are to eliminate elective nodal irradiation and deliver a higher dose of radiation to gross @entity5 volume while sparing normal tissues. Preliminary experience has resulted in promising survival, but should be developed to integrate into the combined treatment to completely control both @entity66 and other microscopically involved lesions. The combination of novel chemotherapeutic agents and molecular targeting therapies with radiation therapy is being investigated. Development of molecular imaging techniques is expected to facilitate more selective dose escalation in @entity5 .

title: [Radiation therapy for XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['local disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors', 'lung cancer']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: DNA double-strand breaks (DSBs) can be repaired via two main mechanisms: non-homologous end joining (NHEJ) and homologous recombination (HR). Our previous work showed that exposure to abiotic stresses resulted in an increase in point mutation frequency (PMF) and @entity2198 ( @entity2198 ), and these changes were heritable. We hypothesized that mutants impaired in DSB recognition and repair would also be deficient in somatic and transgenerational changes in PMF and @entity2198 . To test this hypothesis, we analyzed the genome stability of the @entity958 mutants deficient in ATM (communication between DNA strand break recognition and the repair machinery), @entity40197 (deficient in NHEJ) and @entity40198 (deficient in HR repair) genes. We found that all three mutants exhibited higher levels of DSBs. Plants impaired in ATM had a lower spontaneous PMF and @entity2198 , whereas @entity40197 plants had higher frequencies. Plants impaired in @entity40198 had a lower @entity2198 . @entity2198 in wild-type, atm and @entity40198 plants increased in response to several abiotic stressors, whereas it did not increase in @entity40197 plants. The progeny of stressed wild-type and @entity40197 plants exhibited an increase in @entity2198 in response to all stresses, and the increase was higher in @entity40197 plants. The progeny of atm plants showed an increase in @entity2198 only when the parental generation was exposed to cold or flood, whereas the progeny of @entity40198 plants completely lacked a transgenerational increase in @entity2198 . Our experiments showed that mutants impaired in the recognition and repair of DSBs exhibited changes in the efficiency of DNA repair as reflected by changes in strand breaks, point mutation and @entity2198 . They also showed that the HR @entity40198 protein and the protein ATM that recognized damaged DNA might play an important role in transgenerational changes in @entity2198 .

title: Genome stability of @entity958 atm, @entity40197 and XXXX mutants: somatic and transgenerational responses to stress.

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana']

entities_list: @entity2198 :: ('MESH:D006316', 'Disease') :: ['homologous recombination frequency', 'HRF']

answer: @entity40198 :: (817404(Tax:3702),Gene) :: ['rad51b']


abstract: Over 8 1/2 years, we observed 27 @entity1 with @entity1576 ( @entity1576 ). The inducer drugs were mainly those used in cardiology (9 @entity1 , of whom 8 had @entity2643 @entity55 ), in oncology (8 @entity1 ), in rheumatology (4 @entity1 ; 3 from @entity2361 and 1 from gold), and in neurology (4 cases from @entity4086 derivatives). The main pattern of @entity1576 was a diffuse @entity401 having either a rapid, a slowly progressive or a chronic course. Only the two former patterns offered clearing following withdrawal of the drug. Severe @entity5924 obliterans from @entity2361 (2 cases) and @entity5930 (2 cases) was also observed. The onset of @entity1576 occurred earlier, i.e. following shorter periods of drug administration (months), in the acute @entity401 variant, while it occurred after years of drug exposure in subacute and chronic forms. In contrast to other reports, @entity6113 was not a prominent feature in @entity2643 @entity55 . The outcome was favourable in 16 @entity1 ; @entity204 was encountered during the florid phase of @entity1576 in 3; incapacitating sequelae were noted in 6 @entity1 , leading to subsequent death in 2; the underlying disease accounted for 7 additional @entity204 . Therefore, @entity1576 are relatively common, develop often in @entity1 with severe underlying conditions, and @entity401 is their pattern of predilection. @entity2643 emerges as a common inducer, and accounted for more cases than all chemotherapeutic agents grouped together in our series.

title: [Drug-induced XXXX . Study of 27 cases].

entities_list: @entity6113 :: ('MESH:D008218', 'Disease') :: ['bronchoalveolar lavage lymphocytosis']

entities_list: @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone', 'Amiodarone']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis']

entities_list: @entity5930 :: ('MESH:D011657', 'Disease') :: ['pulmonary eosinophilia']

entities_list: @entity2361 :: ('MESH:D010396', 'Chemical') :: ['d-penicillamine']

entities_list: @entity5924 :: ('MESH:D001988', 'Disease') :: ['bronchiolitis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['DIRD', 'drug-induced respiratory disease']

entities_list: @entity4086 :: ('MESH:D004873', 'Chemical') :: ['ergoline']

entities_list: @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial pneumonitis', 'interstitial lung disease']

answer: @entity1576 :: (MESH:D012131,Disease) :: ['respiratory complications']


abstract: A ten year old @entity1 with linear erythema above the right eyebrow and a groove in the underlying skull bone is described. Histological examination of a biopsy revealed a spotty, periadnexal, perivascular, lymphocytic infiltrate. The papillary dermis was almost absent and the collagen fibres were slightly thickened. Based on the clinical appearance and the histology a diagnosis of @entity2631 (en @entity2631 ) was made. As the signs and symptoms were progressive, treatment with @entity2361 was started. Subsequently the @entity2402 . The shallow groove in the skull bone remained palpable. After thirteen months, treatment was stopped. The @entity1 is currently free of signs and symptoms after a follow-up period of three and a half years. We feel that the strong clinical improvement is due to treatment with @entity2361 rather than to the natural course of the disease.

title: [ @entity2361 in treatment of @entity2631 "en XXXX "].

entities_list: @entity2402 :: ('MESH:D010015', 'Disease') :: ['erythema disappeared']

entities_list: @entity2361 :: ('MESH:D010396', 'Chemical') :: ['D-penicillamine']

entities_list: @entity2631 :: ('MESH:D012594', 'Disease') :: ['coup de sabre', 'linear scleroderma']

answer: @entity2631 :: (MESH:D012594,Disease) :: ['coup de sabre']


abstract: 1. @entity1 plasma Factor XIII (the precursor of fibrin- @entity1160 -fibrin- @entity376 endo-gamma-glutamyltransferase) was randomly labelled by incubation with @entity2822 . The biochemical properties of the system were unaltered by the label. The polarization of the @entity941 fluorescence attached to the plasma protein was measured and the following conclusions were reached. 2. Factor XIII (a'2b2) does not dissociate in the protein-concentration range 10-500 microgram/ml either with or without added @entity141 . 3. @entity21939 (a'2b2) does not dissociate in the absence of @entity141 in the protein-concentration range 10-500 microgram/ml. 4. Additions of @entity141 to @entity21939 result in a decreased polarization of fluorescence as the tetramer dissociates. The decrease in polarization was the same amplitude at protein concentrations 10-500 microgram/ml and @entity141 concentrations 2-66 mM and indicates that the overall process is essentially irreversible. The decrease in polarization consisted of fast and slow exponential phases. Both the rate of the fast phase and the proportion of the reaction it represented increased with @entity141 concentration. 5. A comparison of the rate of dissociation measured by fluorescence polarization and the rate of appearance of enzyme activity in the presence of a protein substrate suggests that the Factor XIII is autoactivated by a soluble a-subunit-containing molecular forming a tight complex with the substrate.

title: Protein-protein interactions in blood clotting. The use of polarization of fluorescence to measure the dissociation of plasma XXXX .

entities_list: @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['glutamine']

entities_list: @entity2822 :: ('CHEBI:37926', 'Chemical') :: ['fluorescein isothiocyanate']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

answer: @entity21939 :: (2162,Gene) :: ['factor XIIIa']


abstract: @entity1271 is a serious problem in dairy sector and among various aetiological agents, the incidence of staphylococci and streptococci remains high in milking animal. The present study was focused on detection of staphylococci and streptococci in winter season. Milk samples (117) of mastitic animals were tested for presence of staphylococci and streptococci using biochemical and PCR based assays. The testing revealed majority of animals (90.6%) were infected with more than one causative agent. Amongst 117 sample, 109 and 90 comprised of staphylococci and 90 streptococci, respectively. Distribution proportion of @entity794 , @entity5938 , @entity5967 , @entity8211 and @entity22193 among the mastitic cases was found as 64.9, 7.7, 5.1, 1.7, 48.7, 65.8 and 0.8%, respectively. Streptococci and staphylococci were observed in different combinations and the frequent were @entity794 / @entity5967 / @entity8211 , @entity794 / @entity8211 , @entity794 / @entity5967 and @entity5967 / @entity8211 which were accounted for 23.9, 19.7, 5.9 and 2.6%, respectively. Approximately half of the (52.1%) cases were observed for reoccurrence of @entity1271 . Reoccurrence of @entity1271 in winter season among these cases was significantly low as compared to summer ( @entity291 -5 cases; buffaloes-2 cases). In addition, prevalence of @entity794 , @entity5967 , @entity8211 , and @entity5938 in reoccurring mastitic cases was 73.7, 63.9, 45.9 and 6.6%, respectively. The observations revealed @entity1271 causing pathogens remains in hidden phase in winter season; however, cannot be neglected. The observation might be helpful in culling or segregation of @entity291 for @entity1271 reduction programmes.

title: Incidence of staphylococci and streptococci during winter in mastitic milk of sahiwal XXXX and murrah buffaloes.

entities_list: @entity5938 :: ('1282', 'Species') :: ['S. epidermidis']

entities_list: @entity22193 :: ('1334', 'Species') :: ['S. dysgalactiae']

entities_list: @entity1271 :: ('MESH:D008413', 'Disease') :: ['Mastitis', 'mastitis']

answer: @entity291 :: (9913,Species) :: ['cow']


abstract: 1. Single motor units were recorded from the masseter, soleus and first dorsal interosseous muscles of normal adult @entity1 . An analysis of discharge patterns was carried out either during slow ramp @entity2472 , or during self-initiated isolated @entity2472 . The isometric myogram was simultaneously recorded.2. Each motor unit was only recruited when the peak force of a brisk contraction exceeded a certain value and a ;ballistic force threshold' (in kg) was estimated for the unit from a large series of brisk contractions of different strengths. For each muscle, the ranking order for recruitment of different motor units recorded from one electrode position was virtually identical in slow ramp versus brisk ballistic contractions of different force (Kendall rank correlation coefficient = 0.91-1.0). There was no evidence for any consistent selective activation of fast twitch motor units in ballistic contractions.3. The ballistic force threshold is considerably reduced with respect to the slow ramp force threshold for the motor units of the soleus muscle. This drop is also marked for the units of the first interosseous and tibialis anterior muscles, whereas it is only small for the units of the masseter muscle. These data have been validated after consideration of the complicating factor related to the possible differential involvement of synergic muscles in ramp or ballistic contractions.4. In the masseter and first interosseous muscles, the time to peak is about 80 msec in small @entity2472 and it increases to about 150 msec in strong contractions. This effect appears related to repetitive discharges of single motor units when their force threshold is exceeded. By contrast, in the soleus muscle, the time to peak remains at about 150 msec both in small and in strong ballistic contractions and most soleus motor units fire only one spike in the ballistic burst.5. Brisk ballistic contractions are graded in force by the recruitment of additional motor units according to their usual rank order. The importance of rate gradation through the repetitive firing of motor units varies in the different @entity1 muscles investigated, being quite significant in isometric brisk contractions of the masseter and first interosseous muscles but much less so in the soleus muscle in which little repetitive firing of single motor units was observed over the range of ballistic forces studied.

title: Ballistic contractions in fast or slow XXXX muscles: discharge patterns of single motor units.

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contractions', 'ballistic voluntary contractions']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVES: This multicenter registry followed up @entity1 with @entity0 treated with breast-conserving surgery and electronic brachytherapy (EBT). This report provides 1- and 2-year updates to the initial publication. METHODS: @entity1 were of age 50 years or more with invasive @entity189 in situ, @entity5 size  <=3 cm, and negative surgical margins. After lumpectomy, @entity1 received EBT in 10 fractions over 5 days (34 Gy total). RESULTS: Of the 69 @entity1 enrolled, 62 were evaluated at 1 year and 20 @entity1 at 2 years after treatment. At 1 year, 28 (45.2%) @entity1 reported adverse events that were possibly, probably, or definitely related to treatment. Most (90%) were grade 1: manageable and typical of radiation therapy. Four events were grade 2: induration/firmness (2), field contracture (1), and @entity2080 (1). One event was grade 3: a draining @entity292 at the lumpectomy site due to residual effects of a @entity0 at 1 month. No recurrences have been reported. Cosmetic ratings were excellent or good in 93.4% of @entity1 at 1 year. Most @entity1 (69%) were energetic most or all of the time. Most @entity1 (69% to 98%) were not affected by individual symptoms of @entity1558 at 1 year. Generally @entity1 who had an adverse event did not report the corresponding symptom on the quality-of-life questionnaire. CONCLUSIONS: This registry followed up @entity1 with @entity0 at 1 and 2 years after breast-conserving surgery and EBT. No recurrences have been reported, and adverse effects were acceptable.

title: Postsurgical treatment of XXXX with electronic brachytherapy: outcomes and health-related quality of life at 1 year.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast infection', 'early-stage breast cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma or ductal carcinoma']

entities_list: @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast disease']

answer: @entity0 :: (MESH:D001943,Disease) :: ['early-stage breast cancer']


abstract: BACKGROUND: We evaluated in which anatomic layer (above the fascia [AF] or below the fascia [BF]) wound infusion of @entity1341 has the best effect on @entity282 after abdominal hysterectomy. METHODS: Sixty-two ASA physical status I and II @entity1 undergoing total abdominal hysterectomy and bilateral salpingo-oophorectomy were enrolled into this prospective randomized, double-blind study. A standard general anesthetic was administered. On completion of the operation, a multiorifice 20-gauge epidural catheter was placed above (group AF, n = 29) or below (group BF, n = 31) the superficial abdominal fascia and 0.25% @entity1341 was administered via a @entity1 -controlled analgesia device, programmed to deliver 9.0 mL with a 60-min lockout interval for 24 h. During the first 6 h after surgery, rescue i.v. @entity3575 (25 microg) was administered to achieve a visual analog scale score of <4 cm. Total @entity1341 consumption, total rescue @entity3575 consumption, @entity158 scores (with resting, coughing, and leg raising), and @entity1 satisfaction scores were compared in both groups. RESULTS: Total @entity1341 consumption over 24 h was significantly lower in group AF rather than group BF (90 +/- 26 mL vs 104 +/- 28 mL, respectively, P < 0.05). The total @entity3575 consumption during the first 6 h after surgery was 109 +/- 59 microg in group AF and 166 +/- 70 microg in group BF (P < 0.01). @entity158 scores were lower in group AF at rest and coughing for the first 5 h and for the first 12 h with leg raise (P < 0.05 for all measurements). Thirteen @entity1 (68%) in group AF defined their satisfaction as excellent whereas six @entity1 (32%) in group BF defined their satisfaction as excellent (P = 0.034). CONCLUSION: We conclude that @entity1341 wound infusion AF provides better postoperative analgesia compared with infusion BF in the first 12 h after abdominal hysterectomy.

title: @entity1341 infusion above or below the fascia for XXXX treatment after abdominal hysterectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']


abstract: The consumption of green tea has been associated with @entity65 . There have been some studies on the influence of green tea on the mineral status of @entity28 subjects, but they have not yielded conclusive results. The aim of the present study is to examine the effects of green tea extract on the mineral, body mass, lipid profile, @entity413 , and antioxidant status of @entity28 @entity1 . A randomized, double-blind, placebo-controlled study was conducted. Forty-six @entity28 @entity1 were randomly assigned to receive either 379 mg of green tea extract, or a placebo, daily for 3 months. At baseline, and after 3 months of treatment, the anthropometric parameters, blood pressure, and total antioxidant status were assessed, as were the levels of plasma lipids, @entity413 , @entity460 , @entity1760 , @entity68 , @entity219 , and @entity920 . We found that 3 months of green tea extract supplementation resulted in decreases in body mass index, waist circumference, and levels of total @entity165 , low-density @entity165 , and @entity412 . Increases in total antioxidant level and in @entity219 concentration in serum were also observed. @entity413 and @entity68 levels were lower in the green tea extract group than in the control, although HDL- @entity165 and @entity1760 were higher in the green tea extract group than in the placebo group. At baseline, a positive correlation was found between @entity460 and body mass index, as was a negative correlation between @entity920 and @entity1674 . After 3 months, a positive correlation between @entity68 and body mass index and between @entity1760 and HDL- @entity165 , as well as a negative correlation between @entity1760 and @entity413 , were observed. The present findings demonstrate that green tea influences the body's mineral status. Moreover, the results of this study confirm the beneficial effects of green tea extract supplementation on body mass index, lipid profile, and total antioxidant status in @entity1 with @entity28 .

title: Effects of green tea supplementation on elements, total antioxidants, lipids, and XXXX values in the serum of @entity28 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular and metabolic diseases']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: Eupatorium odoratum (EO) contains many biologically active compounds, the anticancer effects of which are not well documented. This study evaluates the cytotoxic effects and mechanism of action of EO extracts on MCF-7 and Vero cell lines. Evaluation of the cytotoxic activity using @entity98 assay, morphological alterations, and apoptosis were carried out. Autophagy was evaluated by @entity21684 protein expression. Cytotoxic activity, membrane blebbing and ballooning at 24 hours, replacement by mass vacuolation, and double membrane vesicles mimicking autophagy and cell death were observed in the @entity5 cells. No apoptosis was observed by DNA fragmentation assay. Overexpression of @entity21684 protein indicated autophagic cell death. Cell cycle analysis showed G0 and G2/M arrest. The Vero cells did not show significant cell death at concentrations <100    g/mL. These results thus suggest that @entity1324 and @entity1046 extracts of EO induce cell death through induction of autophagy and hold potential for development as potential anticancer drugs.

title: Autophagic cell death is induced by @entity1324 and XXXX extracts from Eupatorium odoratum in vitro: effects on MCF-7 and vero cell lines.

entities_list: @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity1046 :: (MESH:C007650,Chemical) :: ['ethyl acetate']


abstract: OBJECTIVE: We examined the individual pharmacological effects of the addition of @entity6170 and @entity2449 to @entity16024 on inflammatory markers and adipokines in @entity1 with @entity6 . We analysed the relationships between these variables, the measurements of insulin sensitivity and beta-cell function in @entity1 treated with @entity6170 plus @entity16024 . DESIGN AND @entity1 : One hundred twenty (120) @entity1 with @entity6 were randomized and treated with @entity16024 plus @entity6170 or @entity16024 plus @entity2449 for 12 weeks. The plasma concentrations of the inflammatory markers and adipokines were measured at baseline and after 12 weeks. MEASUREMENTS: Markers of insulin sensitivity and beta-cell function were determined by the quantitative insulin sensitivity check index (QUICKI) and the homeostasis model assessment of beta-cell function (HOMA-beta), respectively. Plasma concentrations of @entity1254 were measured by radioimmunoassay. Plasma concentrations of resistin, @entity5 @entity39 factor-alpha ( @entity310 ), @entity650 ( @entity650 ) and @entity8923 ( @entity8923 ) were measured using ELISA. RESULTS: Improvements in fasting insulin level, QUICKI and HOMA-beta were noted in the @entity6170 -treated group. Only the QUICKI value improved in the @entity2449 -treated group. @entity1254 concentrations significantly increased in the @entity6170 -treated group after 12 weeks. Significant decreases in resistin, C-reactive protein, @entity310 , @entity650 and @entity8923 were seen in the @entity6170 -treated @entity1 but not in the @entity2449 -treated @entity1 . The independent risk factor for the HOMA-beta change according to stepwise multivariate regression analysis was a change in @entity8923 . CONCLUSIONS: @entity6170 , but not @entity2449 , improved the plasma concentrations of inflammatory markers and adipokines in @entity1 with @entity6 . A decrease in @entity8923 is an independent factor for the improvement of HOMA-beta in @entity6 .

title: Effects of @entity6170 and @entity2449 on inflammatory markers and adipokines: decrease in XXXX is an independent factor for the improvement of homeostasis model assessment-beta in @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus']

entities_list: @entity16024 :: ('MESH:C057619', 'Chemical') :: ['glimepiride']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1254 :: ('9370', 'Gene') :: ['Adiponectin', 'adiponectin']

entities_list: @entity6170 :: ('MESH:C089730', 'Chemical') :: ['rosiglitazone', 'Rosiglitazone']

entities_list: @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']

answer: @entity8923 :: (3606,Gene) :: ['interleukin-18']


abstract: PURPOSE: To evaluate the role of pathogens and moderate leukocytes on seminal @entity650 , @entity687 , and sperm parameters in @entity1 undergoing @entity249 investigation. METHODS: Semen samples from @entity1 (n = 171) were divided into three groups on the basis of leukocyte count: no leukocytes (L-;  <= 0.1   10(6)/ml Mio/ml), moderate leukocytes (L   ; >0.1   10(6)/ml and <1   10(6)/ml), and high leukocytes (=leukocytospermia) (L+; >=  1   10(6)/ml). Each group was further classified into two subgroups, according to the presence (B+) or absence (B-) of pathogens. @entity650 , @entity687 , and sperm characteristics were analyzed in each subgroup. A correlation test was performed to show the association between inflammatory parameters and sperm characteristics. RESULTS: No significant differences in leukocyte count, cytokine levels, and sperm characteristics were apparent in subgroups with and without pathogens. Grade b motility was significantly lower in subgroup IIa (L   ,B-) than in subgroup Ia (L-,B-)(p < 0.05). More significant limitations in sperm motility (lower rapid progressive motility and increased percentage of immotile sperm) were observed in subgroup IIIa (L+,B-) compared with subgroup Ia (p < 0.05). Moderate and high leukocytes increased significantly cytokine levels (p < 0.001). CONCLUSIONS: Moderate leukocyte counts could be an indicator of @entity10552 . Seminal pathogens have no influence on cytokine levels and sperm parameters.

title: Influence of pathogens and moderate leukocytes on seminal XXXX , @entity687 , and sperm parameters.

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity10552 :: ('MESH:D005832', 'Disease') :: ['male genital tract inflammation']

answer: @entity650 :: (3569,Gene) :: ['interleukin (IL)-6']


abstract: The EUROCARE Study is a European Union project to assemble survival data from population-based @entity5 registries and analyse them according to standard procedures. We investigated and compared liver, @entity788 survival in 17 countries from 1985 to 1989. Time trends in survival over the 1978-1989 period were also investigated in 12 countries. The overall European mean 1 year relative survival was 16% for primary @entity96 , 26% for @entity1125 and 15% for @entity788 . The corresponding 5-year relative survival was 5, 12 and 4%, respectively. Taking the European average as the reference, the relative risk (RR) of death was at least 20% higher for the three @entity5 in Denmark and Estonia. Survival tended to be higher in Spain for primary @entity96 and @entity1125 . Gender had little influence on survival whilst age at diagnosis was inversely related to prognosis. There was an improvement in 1-year relative survival rate for primary @entity96 : relative risk (RR) of 0.68 (95% confidence interval (CI) of 0.60-0.77) for 1987-1989 versus 1978-1980 and @entity1125 (RR 0.77, 95% CI 0.68-0.87). There was less variation in 5-year relative survival rate over time. Some intercountry survival differences for primary liver, biliary tract and @entity788 exist over Europe. Differences in quality of care, in particular treatment @entity146 , may explain some of these differences in survival. New approaches to the management of these @entity5 need to be found.

title: Survival of patients with primary @entity96 , @entity788 and XXXX in Europe. EUROCARE Working Group.

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic and biliary tract cancer', 'pancreatic cancers']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer']

entities_list: @entity1125 :: ('MESH:D001661', 'Disease') :: ['biliary tract cancer']

answer: @entity1125 :: (MESH:D001661,Disease) :: ['biliary tract cancer']


abstract: INTRODUCTION: Repetitive transorbital alternating current stimulation (rtACS) can improve @entity227 in @entity1 with @entity1781 . Recent retrospective results suggest that rtACS enhances oscillatory brain activity. The exact mechanisms of rtACS are unclear and little is known about possibly frequency-specific neural-plastic mechanisms. An association between bandwidth-confined neural-entrainment and vision recovery maximization could offer a novel therapeutic option for @entity1 with @entity1781 . OBJECTIVES: The goal of this prospective open-label study was to investigate if the enhancement of rhythmic brain activity over 10 days of consecutive rtACS stimulation is associated with visual field recovery. The secondary goal was to investigate neurophysiological mechanisms related to frequency dependent adaptive plasticity. METHODS: 18 @entity1 with @entity227 resulting from pre-chiasmatic partial @entity1781 received rtACS on 10 consecutive days. Daily, subject-specific treatment parameters (<500   A, 9-37  Hz, 25-40  min/day) were defined and EEG-spectra collected prior to and after rtACS. Visual field data was collected at day 1 and 10. The change of spectral-power in classic bandwidths were investigated and correlated with @entity227 recovery. RESULTS: After 10 days of rtACS alpha-power over bilateral occipital electrodes was significantly larger than at baseline (F(Time x alpha-power)p  <  0.01). This effect was progressive over subsequent days of stimulation (cubic-fit, R(2) 0.70, RMSE 0.008). Perimetric results improved significantly, but they were not associated with changes in alpha-synchronization. DISCUSSION: rtACS can induce cumulative bandwidth-confined changes in brain rhythms over multiple sessions. These findings are in line with the notion of brain-state dependent [1] and bandwidth-confined entrainment [2] as well as rtACS facilitated visual recovery [3].

title: Progressive enhancement of alpha activity and visual function in @entity1 with XXXX : a two-week repeated session alternating current stimulation study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual deficits', 'visual field deficit', 'visual field impairments']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy', 'optic nerve damage']

answer: @entity1781 :: (MESH:D009901,Disease) :: ['optic neuropathy']


abstract: OBJECTIVE: To study the excess prevalence of distressful symptoms after radical surgery for @entity150 . METHODS: We included all @entity1 who underwent cystectomy due to @entity150 before 1996 in Stockholm County. A control group was randomly selected from the general population. Information was collected by means of an anonymous postal questionnaire. RESULTS: Completed questionnaires were returned by 310 (71%) controls and 251 (85%) cystectomized individuals. A 5-fold (reservoir) and 9-fold (conduit) increase in defecation urgency and a 4-fold (reservoir) and 6-fold (conduit) increase in faecal leakage were reported in individuals operated on. @entity293 was increased 3-fold in cystectomized individuals compared with controls, during the previous year 26% of the @entity1 reported a symptomatic @entity281 . The perception of a reduced physical attractiveness due to disease was more than 5-fold increased in the @entity1 operated on compared to the controls. The majority, 135 out of 201 (67%), reported that they would have refused alternative bladder-sparing procedures if they decreased the prospects of survival by even as little as 1%. CONCLUSIONS: The @entity1 's situation after cystectomy is considerably impaired due to changed bowel and @entity293 and a sense of decreased attractiveness. However, most @entity1 are in spite of this unwilling to compromise survival.

title: Distressful symptoms after radical cystectomy with urinary diversion for XXXX : a Swedish population-based study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer', 'urinary bladder cancer']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['sexual function, urinary tract infections', 'Urinary tract infection']

answer: @entity150 :: (MESH:D001749,Disease) :: ['urinary bladder cancer']


abstract: The @entity141 sensor @entity7010 ( @entity7010 ) and the @entity141 channel @entity7011 mediate the ubiquitous store-operated @entity141 entry (SOCE) pathway activated by depletion of internal @entity141 stores and mediated through the highly @entity141 -selective, @entity141 release-activated @entity141 (CRAC) current. Furthermore, @entity7010 and @entity7011 , along with @entity40031 , encode store-independent @entity141 currents regulated by either @entity3899 or its metabolite, @entity223 . Orai channels are emerging as important contributors to numerous cell functions, including proliferation, migration, differentiation, and apoptosis. Recent studies suggest critical involvement of STIM/Orai proteins in controlling the development of several @entity5 , including @entity5 of the breast, prostate, and cervix. Here, we quantitatively compared the magnitude of SOCE and the expression levels of @entity7010 and @entity7011 in non-malignant @entity1 primary astrocytes (HPA) and in primary @entity1 cell lines established from surgical samples of the @entity1313 multiforme ( @entity463 ). Using @entity141 imaging, patch-clamp electrophysiology, pharmacological reagents, and gene silencing, we established that in @entity463 cells, SOCE and CRAC are mediated by @entity7010 and @entity7011 . We further found that @entity463 cells show upregulation of SOCE and increased @entity7011 levels compared to HPA. The functional significance of SOCE was evaluated by studying the effects of @entity7010 and @entity7011 knockdown on cell proliferation and invasion. Utilizing Matrigel assays, we demonstrated that in @entity463 , but not in HPA, downregulation of @entity7010 and @entity7011 caused a dramatic decrease in cell invasion. In contrast, the effects of @entity7010 and @entity7011 knockdown on @entity463 cell proliferation were marginal. Overall, these results demonstrate that @entity7010 and @entity7011 encode SOCE and CRAC currents and control invasion of @entity463 cells. Our work further supports the potential use of channels contributed by Orai isoforms as therapeutic targets in @entity5 .

title: @entity7010 and XXXX mediate CRAC channel activity and are essential for @entity1 @entity463 invasion.

entities_list: @entity7010 :: ('6786', 'Gene') :: ['stromal interacting molecule 1', 'STIM1']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'malignancies']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor glioblastoma']

entities_list: @entity3899 :: ('CHEBI:32395', 'Chemical') :: ['arachidonate']

entities_list: @entity223 :: ('MESH:D017997', 'Chemical') :: ['leukotriene C4']

answer: @entity7011 :: (84876,Gene) :: ['Orai1']


abstract: Male Copenhagen x Fisher F1 @entity35 , transplanted with the @entity342 -sensitive Dunning R3327 PAP @entity35 @entity263 , were castrated when @entity5 volumes were approximately 1300 mm3. The @entity35 were thereafter followed with measurements of @entity5 volume. Castration stopped @entity5 growth, but some of the @entity5 started to regrow after 7-36 weeks. These @entity5 relapsing from castration treatment were now considered to be @entity342 -insensitive. In this study, we defined relapse as the time when the @entity5 volume had increased to 200% of the volume at the time for castration. At this time, the @entity35 were treated either with @entity53 -17 beta (E2, 50 micrograms s.c. daily) or vehicle for 8 weeks. After this period, @entity5 morphology was examined. The @entity5 in the vehicle-treated group were heterogeneous, and both highly and more dedifferentiated parts were present. The @entity5 growth rate was correlated to the epithelial cell nuclear size and its variance, and to the mitotic index. In the E2-treated group, @entity5 growth rate was retarded throughout the treatment period, and dedifferentiated @entity5 areas were rare. @entity172 treatment resulted in a reduction of nuclear area and mitotic index, a changed nuclear shape, and an increased apoptotic index compared to that in vehicle-treated @entity5 . By castration, it is possible to induce an alteration of the @entity342 -sensitive Dunning R3327 @entity5 phenotype to an @entity342 -insensitive @entity5 with an altered morphology. @entity53 -17 beta apparently inhibits not only the growth, but also postpones the castration-induced @entity5 .

title: @entity172 treatment postpones the castration-induced XXXX .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogen']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic adenocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'dedifferentiation of the tumor', 'PAP tumor', 'tumors']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['Estradiol', 'estradiol']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['dedifferentiation of Dunning R3327-PAP prostatic adenocarcinoma']


abstract: PURPOSE: To evaluate the safety and feasibility of a simplified zero @entity63 technique using kidney donor computed tomographic (CT) angiography and conventional laparoscopic bulldog clamps. MATERIALS AND METHODS: We conducted a review of seven robot-assisted partial nephrectomies (RAPNs) performed by a single surgeon from January 2012 to May 2012. Using a simplified protocol of 3-dimentional reconstruction, tertiary arterial branches supplying the @entity5 were selectively clamped prior to resection. We used conventional laparoscopic bulldog clamps instead of microsurgical vessel clamps. The @entity1 ' demographic information, perioperative outcomes, pathologic outcomes and pre- and postoperative renal functions up to 3 months follow-up were analyzed. RESULTS: RAPN were successfully performed for seven @entity703 . There were no significant differences in the total operation time, estimated @entity190 or postoperative outcomes compared with published literature on standard RAPN. Negative surgical margins were reported in all cases. CONCLUSIONS: We presented a simplified-zero @entity63 technique using kidney Donor CT angiography and conventional laparoscopic bulldog clamps. We have also demonstrated its safety and feasibility in @entity1 with @entity703 . This modified technique can be easily adopted by most surgeons who are currently performing RAPN.

title: Simplified zero XXXX in robot assisted partial nephrectomy: initial yonsei experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['complex renal hilar tumors']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemia']


abstract: BACKGROUND: Approximately one third of the parents of @entity1 with @entity245 or @entity2438 reports an early regression of unknown cause in their @entity1 's language, sociability, and play. @entity410 or an @entity302 electroencephalogram (EEG) are associated with language regression in acquired @entity302 ( @entity12924 ) and some other pediatric @entity302 . The importance of @entity302 or @entity302 EEGs as contributors to @entity2438 regression is not known. METHOD: Subjects were 482 @entity1 and 103 @entity1 on the @entity2438 spectrum seen consecutively in consultation by one @entity1 neurologist. Data on @entity2438 regression, @entity410 , sleep EEGs, and cognitive function were entered prospectively into a data base. RESULTS: Of the 585 @entity1 , 176 (30%) had a history of regression, and 66 @entity1 (11%) had a history of @entity302 , defined as two or more unprovoked @entity410 . Among 392 @entity1 with available sleep EEGs, the EEG was @entity302 in 59% of the 66 @entity302 @entity1 and 8% of the 335 nonepileptic @entity1 . @entity2357 had occurred equally among @entity1 without @entity410 and in those with @entity302 . @entity2357 was associated with an @entity302 in 14% of 155 nonepileptic @entity1 who had undergone a regression, as opposed to 6% of 364 @entity1 with neither regression nor @entity302 . Mean age at regression was 21 months. There was no difference in the proportion of @entity1 with @entity302 or @entity302 EEGs who had regressed before or after 2 years of age. Approximately half of the @entity302 were centrotemporal, whether or not the @entity1 was @entity302 or had regressed. @entity1 with lower cognitive function were more likely to have undergone regression than those with @entity73 (34% vs 20%). CONCLUSION: @entity302 occur in a significant minority of @entity2438 @entity1 with a history of regression and in a smaller minority without regression. Prompt recognition of regression and recording of prolonged sleep EEGs is recommended, even though information on the potential efficacy of antiepileptic treatment to improve language and behavior in @entity2438 @entity1 with @entity302 or an @entity302 is still lacking.

title: @entity2357 in XXXX : @entity410 and @entity302 electroencephalogram correlates.

entities_list: @entity1 :: ('9606', 'Species') :: ['Children', 'girls', 'child', 'children', 'boys']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['Seizures', 'seizures']

entities_list: @entity12924 :: ('MESH:D018887', 'Disease') :: ['Landau-Kleffner syndrome']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['better cognitive skills']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['pervasive developmental disorders']

entities_list: @entity2438 :: ('MESH:D001321', 'Disease') :: ['autistic spectrum disorders', 'autistic']

entities_list: @entity2357 :: ('MESH:C537770', 'Disease') :: ['Regression']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Epilepsy or epileptiform EEGs', 'epileptic', 'epileptic syndromes', 'epileptic aphasia', 'epilepsy', 'epileptiform', 'epileptiform EEG', 'epileptiform discharges']

answer: @entity245 :: (MESH:D002658,Disease) :: ['pervasive developmental disorders']


abstract: PURPOSE: To evaluate and report the efficacy of fibrin glue (FG)-assisted augmented @entity8 ( @entity8 ) in @entity1 with large @entity1035 . METHODS: In a retrospective case series, 10 @entity1 with @entity1035 more than 2 mm in diameter were treated with "FG-assisted augmented @entity8 ." A 5- or 7-ply "augmented @entity2907 membrane" (AM) was constructed by applying FG to each sheet of AM to repair the corneal perforation. The augmented AM was designed 0.5 mm larger than the diameter of the perforation. The augmented AM was transplanted onto the perforation site with 10-0 nylon suture. If needed, additional overlay AM was sutured on top. RESULTS: The mean ulceration diameter was 2.7 +/- 0.95 mm (range, 2-5 mm). All @entity1 retained their own globes after the procedure and had well-formed deep anterior chambers, and 90% of @entity1 showed complete epithelialization over the AM. The mean reepithelialization time was 14.9 +/- 4.9 days (range, 10-24 days). No eyes showed evidence of @entity281 or recurrent corneal melting during the follow-up period. CONCLUSIONS: FG-assisted augmented @entity8 was easily performed for repairing large @entity1035 . This surgical method was very helpful in stabilizing the wound in the early postoperative period.

title: Fibrin glue-assisted augmented XXXX for the treatment of large noninfectious @entity1035 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['amniotic membrane transplantation', 'AMT']

entities_list: @entity1035 :: ('MESH:D057112', 'Disease') :: ['corneal perforations']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity8 :: (MESH:D007674,Disease) :: ['amniotic membrane transplantation']


abstract: Twenty-five @entity11 of the cerebral hemisphere in @entity1 were examined. Most @entity11 in @entity1 have relatively clear margins and less infiltrative potential. Radiosurgery has a role in the treatment of these @entity5 in addition to reducing the risk of radiation injuries developing later. Fifteen @entity1 were alive 1-27 years (mean 8.4) following treatment and 10 @entity1 died. Histologic examination demonstrated 10 differentiated @entity11 , 10 poorly differentiated @entity11 and 5 other @entity11 . Most @entity5 had relatively clear margins on computed tomography and/or magnetic resonance images, and peritumoral @entity4 was slight. In 9 autopsy cases, @entity5 dissemination and/or @entity3 were seen in 7. However, @entity5 infiltration was not extensive, and @entity5 margins were found in some cases. Thus, @entity13 in @entity1 have relatively clear margins and low infiltrative potential. Radiosurgery has a role in the treatment of these @entity5 .

title: Pathobiology of @entity13 in XXXX and the role of radiosurgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity13 :: ('MESH:C564230', 'Disease') :: ['cerebral gliomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'clear tumor', 'tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['hemispheric gliomas', 'gliomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: The current study was conducted to determine the significance of a diagnosis of atypical squamous cells of undetermined significance (ASCUS) in perimenopausal and postmenopausal @entity1 . METHODS: The reports for all Papanicolaou (Pap) smears viewed in the study institution's cytology laboratory over a 6-month period were reviewed. @entity1 were divided into premenopausal (age < or = 45 years), perimenopausal (ages 46-54 years), and postmenopausal (age > or = 55 years) categories. Slide review and 2-year follow-up were obtained for selected cases diagnosed as ASCUS. ASCUS cases among the perimenopausal @entity1 were compared with an age-matched control group. RESULTS: The total number of abnormal Pap smears in the premenopausal, perimenopausal, and postmenopausal categories were 770 (6.8%), 104 (4.3%), and 67 (2.9%), with 482, 83, and 41 diagnoses of ASCUS, respectively. The ratio of ASCUS to @entity2784 ( @entity2784 ) was 2.2 overall and 1.9, 7.5, and 4.1, respectively, for each group (P < 0.001). The positive predictive value for a diagnosis of @entity2784 on subsequent Pap smears or biopsies was 22%, 12.2%, and 29.7%, respectively. Slide review showed that the premenopausal ASCUS cases appeared to have a higher percentage of nuclear-cytoplasmic ratio increase and nuclear membrane irregularities compared with the other categories (P = 0.03 and P = 0.02, respectively) and the perimenopausal group was found to have more ASCUS in metaplastic cells (P = 0.03). In perimenopausal @entity1 , slides diagnosed as ASCUS demonstrated more air-drying artifact than the control group (P = 0.004) but had less obvious @entity194 (P = 0.01). CONCLUSIONS: Despite a decreased abnormality rate with increasing age, the results of the current study show that the perimenopausal and postmenopausal groups appear to have elevated ASCUS-to- @entity2784 ratios. ASCUS appears to have a particularly low positive predictive value for @entity2784 in perimenopausal @entity1 , and therefore most likely is overcalled in this age group. This may be attributable in part to air-drying artifact and subtle atrophic changes.

title: Significance of a diagnosis of atypical squamous cells of undetermined significance for Papanicolaou smears in perimenopausal and postmenopausal XXXX .

entities_list: @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesions', 'SIL']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: Intravenous thrombolysis with recombinant tissue-type plasminogen activator is the approved treatment for acute @entity385 within 4.5 h from symptoms onset. Evidence suggests the earlier treatment was given, the greater the chance of a favorable outcome. We investigated if the delay in hospital presentation has been modified in the past 8 years. Acute @entity63 strokes admitted to the Emergency Department of the Careggi Hospital, Florence from March 2004 to December 2012 were prospectively collected in the Careggi @entity64 Registry. Proportion of @entity1 presenting  <= 2 h, 2-3.5, 3.5-6, and >6 h from symptom onset or with awakening @entity64 were compared. From March 2004 to December 2012, 3,856 @entity1 with acute @entity385 arrived to the Careggi Emergency Department. During the period, 28.3 % of @entity1 arrived  <= 2 h from symptoms onset and 9.8 % between 2 and 3.5 h. The proportion of time-eligible @entity1 is steady in the first years with a slight increase in 2011 and 2012. Early presentation is significantly associated with younger age, @entity1779 , and @entity64 severity. In this study, about one-third of acute @entity63 strokes arrived at the Emergency Department within the therapeutic time-window for intravenous thrombolysis. There is only a slight increase in early presentation through the period, mainly in the last 2 years. Additional efforts are required to impact deeply on the rates of time-eligible @entity1 .

title: Delay in presentation after acute XXXX : the Careggi @entity64 Registry.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['Hospital Stroke', 'stroke']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hemorrhage']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: A significant number of @entity1 with infective @entity886 develop @entity2333 . Although antibiotics may occasionally sterilize an @entity2333 , most @entity1 require surgical intervention. A review of our experience with 21 consecutive @entity1 surgically treated for @entity2333 disclosed that 13 @entity1 had prosthetic valve and eight had native @entity886 . The predominant microorganism was @entity794 , particularly in those @entity1 with native @entity886 . The abscess was limited to the aortic annulus in 10 @entity1 and was either multiple or had perforated the left ventricular outflow tract in 11 @entity1 . Most @entity1 were desperately ill at the time of operation. Repair was accomplished by aggressive debridement of all apparently infected tissue and reconstruction of the left ventricular outflow tract with autologous pericardium. Although @entity260 were common, only one @entity1 died in hospital. Operative survivors have been followed up from 3 to 68 months (mean, 29 months). One @entity1 died of complications of repair of a thoracoabdominal @entity439 34 months after surgery; his prosthetic aortic valve and patch were intact at autopsy. No @entity1 has experienced recurrent @entity5880 , or prosthetic valve dehiscence.

title: Surgical treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5880 :: ('MESH:D000785', 'Disease') :: ['infection, pericardial patch aneurysm']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve endocarditis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic annular abscess', 'aortic root abscess']

answer: @entity2333 :: (MESH:D001018,Disease) :: ['aortic root abscess']


abstract: To compare the cytokine response to exhaustive running in recreationally-active (RA) and endurance-trained (ET) @entity1 . Eleven RA @entity1 (VO2max 55    7 mL  min(-1)  kg(-1)) and 10 ET @entity1 (VO   max 68    7 mL  min(-1)  kg(-1)) followed a controlled diet and refrained from volitional exercise for 8 days. On the fourth day, @entity1 completed 60 min of treadmill running (65 % VO   max), followed by intermittent running to exhaustion (70 % VO   max). Fasting blood was obtained at baseline, after 20, 40 and 60 min of exercise, at the end of intermittent exercise, during 2 h of recovery and on four follow-up days (FU1-FU4). Tumour @entity39 factor-alpha ( @entity310 ), @entity1356 ( @entity1356 ), @entity650 ( @entity650 ), @entity1193 ( @entity1193 ) and @entity908 kinase (CK) were measured. Exercise increased the concentrations of all cytokines and CK, but there were no significant differences between groups. @entity1356 increased (2.2-2.5-fold, P < 0.001) during exercise, while @entity310 was increased (1.6-2.0-fold, P < 0.001) during exercise and for 2 h post-exercise. @entity650 (71-84-fold, P < 0.001) and @entity1193 (52-64-fold, P < 0.001) were increased throughout exercise and up to FU1, peaking immediately after exercise and at 1.5-2 h post-exercise, respectively. CK concentrations were increased (P < 0.001) throughout exercise and up to FU4, peaking at FU1, but were not associated with changes in any cytokines. Exhaustive running resulted in modest and transient increases in @entity310 and @entity1356 , and more marked and prolonged increases in @entity650 and @entity1193 , but improved training status did not affect this response. Increased CK might indicate either exercise-induced muscle cell disruption or increased cell permeability, although neither appears to have contributed to the increased cytokine concentrations.

title: Cytokine response to acute running in recreationally-active and endurance-trained XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'men']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity1193 :: ('3557', 'Gene') :: ['IL-1ra', 'interleukin-1 receptor antagonist']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: We investigated the lipoproteins and apoproteins in human serum and @entity1143 of different origin: transudates, inflammatory exudates, and malignant exudates. Transudates had a low @entity165 content of 35 +/- 12 mg/dl (mean +/- SD) because of low levels of low-density lipoprotein (LDL) @entity165 --representing 16% of serum levels--whereas inflammatory exudates ( @entity165 92 +/- 26 mg/dl) and malignant exudates ( @entity165 86 +/- 6 mg/dl) exhibited high levels of LDL, with 67% and 69% of serum levels. @entity755 level corresponded with LDL and presented with multiple split-products in @entity3208 - @entity2975 gel electrophoresis in exudative effusions. LDL levels in effusions correlated with serum levels in exudates but did not correlate with those in transudates. In contrast, lipoprotein(a) appeared in all effusions from @entity1 with detectable serum levels. The isoforms were similar as demonstrated by immunoblotting. Differences were found in the composition of the high-density lipoprotein (HDL) fraction: transudates had @entity165 -rich HDL when compared with serum. HDL particles of malignant exudates were poor in @entity165 , and isoelectric focusing demonstrated more sialized @entity2204 . A strongly abnormal HDL level with accumulation of @entity165 was found in a long-standing tuberculous effusion. In conclusion, @entity165 in acute effusions is bound to lipoproteins and derived from the blood. The difference in total @entity165 levels between transudates and exudates is based on the lack of LDL in transudates. Transudates show the lipoprotein characteristics of interstitial fluid. Alterations of lipoproteins occur in @entity32 and in malignancy with possible de novo synthesis of @entity2204 by @entity5 cells. Lipoprotein(a) accumulates independently from LDL in the pleural space, a finding that supports the view that the physiologic function of lipoprotein(a) is located in the interstitial space.

title: Lipoproteins and apolipoproteins in @entity1 XXXX .

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity2204 :: ('348', 'Gene') :: ['apolipoprotein E']

entities_list: @entity755 :: ('338', 'Gene') :: ['Apolipoprotein (apo) B']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1143 :: (MESH:D010996,Disease) :: ['pleural effusions']


abstract: PURPOSE: The purpose of this study was to perform a magnetic resonance imaging (MRI) follow-up study of @entity79 in a group of @entity1 with @entity697 that were reconstructed and followed-up for a minimum of 2 years. TYPE OF STUDY: Cohort study. METHODS: The study group included 21 @entity1 with a mean age of 31 years whose initial MRI scans showed associated @entity79 . @entity1 were included if they had an acute isolated ACL tear, no documentation of an episode of @entity130 to the affected knee during the follow-up period, and no evidence of @entity130 at the time of arthroscopy. All @entity1 had preoperative MRI scans and underwent arthroscopic ACL reconstruction using a bone-patellar tendon autograft an average of 2 months after injury. The preoperative MRI scans were analyzed using a 3-level grading system based on the appearance and location of @entity79 . A second MRI of the knee was obtained from 24 to 64 months postoperatively (average 34 months). The presence of resolution of @entity79 was determined and correlation with clinical scoring established. RESULTS: This study showed resolution of all type I lesions and 91% of @entity75 (10 of 11). In all @entity75 , an articular cartilage thinning and @entity308 was observed after 2 years of follow-up. In 15 @entity1 (71%), MRI showed that the @entity79 had resolved without apparent sequelae. In the remaining 6 @entity1 (29%), sequelae of the @entity75 were evident on MRI. CONCLUSIONS: According to our clinical data, there was no correlation between scores obtained from @entity1 with resolved lesions against those with osteochondral sequelae. Although long-term clinical implications of these findings are uncertain, a severe @entity75 sustained at the time of @entity6151 seems to be persistent on MRI even after a successful reconstruction.

title: Magnetic resonance imaging follow-up study of XXXX associated with anterior cruciate ligament ruptures.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute anterior cruciate ligament (ACL) ruptures']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['type III lesions', 'type II lesions', 'osteochondral lesion', 'occult osteochondral lesion']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone bruises']

entities_list: @entity6151 :: ('MESH:D057971', 'Disease') :: ['ACL rupture']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['cartilaginous injury', 'repeated injury']

answer: @entity79 :: (MESH:D001847,Disease) :: ['bone bruises']


abstract: BACKGROUND: Immune system dysfunction is implicated in the pathophysiology of @entity308 , and is hypothesized to normalize with successful treatment. We aimed to investigate @entity1200 in @entity308 and its response to @entity1654 . METHODS: 55 melancholic @entity308 @entity1 and 26 controls participated. 33 @entity1 (60%) were referred for @entity1654 . Blood samples were taken at baseline, one hour after the first @entity1654 session, and 48h after @entity1654 series completion. RESULTS: At baseline, melancholic @entity308 @entity1 had significantly higher levels of the pro-inflammatory cytokine @entity650 , and lower levels of the regulatory cytokine @entity2533 than controls. A significant surge in @entity650 levels was observed one hour after the first @entity1654 session, but neither @entity650 nor @entity2533 levels normalized after completion of @entity1654 series. Seventy per cent (n=23) of @entity1654 recipients showed clinical response and 42% (n=10) reached remission. Neither @entity650 nor @entity2533 changes correlated with clinical improvement following @entity1654 . No significant changes in @entity688 , @entity310 and CRP levels were found in relation to @entity308 or response to @entity1654 . LIMITATIONS: As a naturalistic study, some potential confounders could not be eliminated or controlled, including medication use. CONCLUSIONS: Melancholic @entity308 @entity1 demonstrated a peripheral increase in @entity650 and reduction in @entity2533 , which did not normalize despite clinical response to @entity1654 . These findings may be consistent with emerging hypotheses of the role of @entity32 in mediating @entity2252 expression. The implications of @entity32 in the melancholic @entity308 population for future medical health, particularly cardiovascular risk, are largely unknown and warrant further investigation.

title: Alteration of immune markers in a group of melancholic @entity308 XXXX and their response to electroconvulsive therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['melancholic depression', 'melancholia', 'depressed', 'major depression']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity988 and other @entity734 continue to be a problem among younger and older populations. The prevalence of @entity734 has only been studied among outpatients and in limited samples of inpatients in Kenya. This study therefore aimed to establish patterns of @entity734 in @entity1 admitted in general medical facilities in Kenya. The @entity167 Use Disorders Identification Test (AUDIT) and the @entity167 , Smoking and Substance Involvement Screening Test (ASSIST) were used to measure the prevalence of @entity734 among @entity1 in 10 medical facilities in Kenya. Data were collected over a 4-week period in November 2005. The overall @entity167 user rate using the two instruments was 25.1% and 25.5%, respectively. All the @entity1 who used @entity167 exhibited pathological use, which bordered from harmful use to dependence. Apart from @entity167 , other abused substances included @entity286 , @entity835 , @entity2072 , @entity889 /khat, and sedatives. The clinicians' pick rate for substance use in general hospitals was negligible. These findings suggest the need for specific enquiry for @entity734 in @entity1 in general medical facilities.

title: Prevalence of @entity734 among XXXX in general medical facilities in Kenya.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol', 'Alcohol']

entities_list: @entity988 :: ('MESH:D000437', 'Disease') :: ['Alcoholism']

entities_list: @entity835 :: ('MESH:D002189', 'Disease') :: ['cannabis']

entities_list: @entity889 :: ('MESH:D000662', 'Chemical') :: ['amphetamines']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['substance abuse']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: The health hazard of the @entity209 ( @entity209 ) is increasing, yet there is no effective pharmacologic treatment to this entity as a whole. Recently, @entity17211 was found to play an important role in the development of @entity209 . We studied the effect of the @entity9781 agonist @entity6170 on adiponectin and the metabolic profile in the @entity948 -induced @entity101 , @entity1717 , @entity6308 @entity35 model. METHODS: Thirty male @entity35 were divided into three groups. Ten were fed standard @entity35 chow for 5 weeks, 10, a @entity948 -enriched diet for 5 weeks, and 10, a @entity948 -enriched diet for 5 weeks, with @entity6170 10 mg/kg/d added during the last 2 weeks. Blood pressure (BP), oral @entity413 tolerance test (OGTT), plasma insulin, @entity1674 , and adiponectin were recorded, as well as mRNA levels of the adiponectin gene in visceral adipose tissue. RESULTS: @entity948 -fed @entity35 developed @entity209 as manifested by the increase in systolic BP (from 139 +/- 3 to 158 +/- 4 mm Hg, P < .05), insulin (from 26 +/- 1.6 to 40 +/- 2.5 muU/mL, P < .05), @entity1674 (from 91 +/- 9 to 304 +/- 24 mg/dL, P < .05), and impaired OGTT (area under the curve from 13,894 +/- 246 to 17,725 +/- 700 mg/dL/min). Treatment with @entity6170 reversed these effects and reduced BP to 133 +/- 7 mm Hg, insulin levels to 30 +/- 2.8 muU/mL, @entity1674 to 116 +/- 9 mg/dL, and the OGTT to 15,415 +/- 372 mg/dL/min (P < .05 for all variables). In addition, @entity6170 increased plasma levels of adiponectin fourfold from 4.3 +/- 0.1 to 18.4 +/- 0.6 mug/mL (P < .05). This increase was coupled with 3.8-fold increase in adiponectin mRNA in visceral adipose tissue. CONCLUSIONS: This study shows for the first time that in an animal model of @entity209 , the insulin sensitizer, @entity6170 , improves the metabolic profile and increases plasma levels of adiponectin and its gene expression. It is possible therefore that @entity6170 exerts its beneficial effects by increasing the levels of adiponectin.

title: Effect of @entity9781 agonist on adiponectin levels in the @entity209 : lessons from the high XXXX fed @entity35 model.

entities_list: @entity17211 :: ('MESH:C567258', 'Disease') :: ['hypoadiponectinemia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats']

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose', 'Fructose']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity6308 :: ('MESH:D064250', 'Disease') :: ['hypertriglyceridemic']

entities_list: @entity1717 :: ('MESH:D044903', 'Disease') :: ['hyperinsulinemic']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['MS', 'metabolic syndrome']

entities_list: @entity6170 :: ('MESH:C089730', 'Chemical') :: ['rosiglitazone']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity948 :: (MESH:D005632,Chemical) :: ['fructose']


abstract: OBJECTIVES: @entity1988 ( @entity1988 ) is frequently associated with a poor long-term prognosis. Renal biopsy is the diagnostic method of choice in this condition. Urine biomarkers have been mentioned in the diagnosis of @entity1988 . The study(,)s purpose was to evaluate the performance of urinary @entity2842 (UMCP-1) as a biomarker of renal involvement in @entity1252 . MATERIALS AND METHODS: Forty-one recently diagnosed @entity1252 @entity1 (8 male and 33 female) without renal involvement (group 1) and twenty six @entity1 (8 male and 18 female) with @entity1988 (group 2), proven by biopsy, were recruited to this study. UMCP-1 sensitivity and specificity for identifying biopsy-proven @entity1310 were calculated, and a receiver operating characteristic (ROC) curve was constructed to quantify how definitely UMCP-1 distinguishes between @entity1 with and without @entity1988 . RESULTS: The mean value of UMCP-1 levels were 733.07 pg/ml    1282.54 and 144.16 pg/ml    137.90 in @entity1 with and without @entity1988 respectively. The UMCP-1 level was significantly higher in group 2 than group 1. There was no significant correlation between UMCP-1 and 24-hour urine protein (r = 0.031, P= 0.874). The area under the ROC curve was 0.727 with a CI 95% of 0.597 to 0.857 (P=0.002). Using a cut-off value of 82 pg/ml,UMCP-1 had a sensitivity of 88.5% and a specificity of 46.3% for identifying @entity1988 . CONCLUSION: UMCP-1 can serve as a biomarker of @entity1988 although further longitudinal studies of these biomarkers are required in @entity1988 .

title: Urine Monocyte Chemoattractant Protein-1(UMCP-1) as a Biomarker of Renal Involvement in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1310 :: ('MESH:D009393', 'Disease') :: ['nephritis']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus']

entities_list: @entity1988 :: ('MESH:D008181', 'Disease') :: ['Lupus nephritis', 'LN']

entities_list: @entity2842 :: ('6347', 'Gene') :: ['monocyte chemoattractant protein 1']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['Systemic Lupus Erythematosus']


abstract: BACKGROUND AND STUDY AIMS: Open pancreatic necrosectomy is the standard treatment for @entity39 but is associated with significant morbidity, mortality, and prolonged hospital stay. Percutaneous or endoscopic necrosectomy are alternative techniques. We evaluated the use of endoscopic necrosectomy for treatment of @entity1 with @entity39 that could be accessed through the posterior wall of the stomach. @entity1 AND METHODS: We retrospectively analyzed the indication, @entity1 status according to acute physiology and chronic health evaluation (APACHE) 2 severity score, and success of endoscopic necrosectomy as primary treatment, in selected @entity1 with localized @entity39 , who presented between May 2002 and October 2004. After the @entity39 cavity had been accessed, with the assistance of endoscopic ultrasound, a large orifice was created and @entity39 was removed using endoscopic accessories under radiological control. Follow-up was clinical and radiological. RESULTS: 13 @entity1 (nine @entity1 , four @entity1 , mean age 53 years), 11 with positive bacteriology, underwent attempted endoscopic necrosectomy. Median APACHE 2 score on presentation was 8 (range 1-18). Four @entity1 needed intensive therapy unit care and one other @entity1 required (nonventilatory) high-dependency unit care only. @entity39 was successfully treated endoscopically in 12 @entity1 , requiring a mean of 4 endoscopic interventions (range 1-10); one @entity1 required open surgery; two underwent additional percutaneous necrosectomy and one required laparoscopic drainage. Two @entity1 died of complications unrelated to the procedure. The 11 survivors have a median (range) follow-up of 16 (6-38) months. CONCLUSION: Endoscopic necrosectomy is a safe method for treatment of @entity39 . Multiple procedures are usually needed. It may be combined with other methods of surgical intervention. Larger prospective studies will more precisely define its role.

title: Endoscopic necrosectomy as primary therapy in the management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'Necrosis', 'necrotic debris', 'infected pancreatic necrosis']

answer: @entity39 :: (MESH:D009336,Disease) :: ['infected pancreatic necrosis']


abstract: STUDY DESIGN: A randomized, double-blind controlled study. OBJECTIVE: To assess the efficacy and safety of intrathecal @entity3575 in the relief of @entity282 in @entity1 undergoing lumbar spinal surgery. SUMMARY OF BACKGROUND DATA: @entity3575 has been used as a spinal analgesic in surgery and obstetrics with several studies promoting its efficacy and safety. There is no evidence in the literature about intrathecal @entity3575 in lumbar spinal surgery. Previous studies have looked at the use of intrathecal @entity1286 and conclude that it is effective but also associated with @entity1576 . METHODS: Sixty @entity1 undergoing posterior lumbar spine decompression with or without instrumented fusion were randomized to receive either 15 mug of @entity3575 intrathecally under direct vision or nothing just before wound closure. After surgery, all @entity1 received intravenous (IV) @entity1286 via @entity1 -controlled analgesia system (PCA) syringe driver. Outcome measures included visual analogue scores (VAS) for @entity158 , time to first bolus of IV @entity1286 PCA, and total amount of @entity1286 PCA used. RESULTS: The @entity1 who received @entity3575 demonstrated a significant decrease in their mean @entity158 VAS, an increase in the time to first PCA bolus, and a 41% reduction in the total PCA @entity1286 received. No @entity1 had respiratory compromise requiring treatment. There was no significant difference between the two groups with respect to age, gender, and case mix. CONCLUSION: Intrathecal @entity3575 is effective at reducing @entity158 and @entity1286 PCA use after lumbar spinal surgery with minimal @entity1576 .

title: A prospective randomized double-blind trial of the use of intrathecal @entity3575 in XXXX undergoing lumbar spinal surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory depression']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl', 'Fentanyl']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The National Institute for Occupational Safety and Health conducted an initial, task-based comparative assessment to determine the potential for release of @entity505 nanofibers (CNFs) during dry @entity12168 , wet cutting, grinding, and sanding (by machine and hand) of plastic composite material containing CNFs. Using a combination of direct-reading instruments and filter-based air sampling methods for airborne mass and @entity1579 ( @entity1579 ), concentrations were measured and characterized near sources of particle generation, in the breathing zone of the workers, and in the general work area. Tasks such as surface grinding of composite material and manually transferring dry CNFs produced substantial increases in particle number concentration (range = 20,000-490,000 1-cm(-3)). Concomitant increases in mass concentration were also associated with most tasks. Nearly 90% of all samples examined via @entity1579 indicated that releases of CNFs do occur and that the potential for exposure exists. These findings also indicate that improperly designed, maintained, or installed engineering controls may not be completely effective in controlling releases. Unprotected skin exposure to CNFs was noted in two instances and indicated the need for educating workers on the need for personal protective equipment. [Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource: a PDF file containing information on materials, evaluated processes, personal protective equipment, and existing ventilation/engineering controls.].

title: Evaluation of the potential airborne release of XXXX nanofibers during the preparation, grinding, and cutting of epoxy-based nanocomposite material.

entities_list: @entity12168 :: ('MESH:C562385', 'Disease') :: ['material handling']

entities_list: @entity1579 :: ('MESH:D017096', 'Disease') :: ['transmission electron microscopy', 'TEM']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']