abstract: BACKGROUND: This study was undertaken to measure survival of @entity1 with multicystic @entity298 treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy through a multi-institutional collaboration. METHODS: A multi-institutional data registry, established by the Peritoneal Surface Oncology Group, was used to identify @entity1 with @entity298 and the subgroup with @entity5 , treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Outcomes for this subgroup are reported. The primary endpoint was overall survival. A secondary endpoint was the incidence of treatment-related complications. RESULTS: Of 405 @entity1 with @entity298 , 26 (6  4 per cent) had @entity5 . There were 20 @entity1 and six @entity1 with a mean(s.d.) age of 42(12) years. The median peritoneal @entity189 index (PCI) was 14 (range 6-39). There was no perioperative mortality. Six @entity1 developed @entity532 . After a median follow-up of 54 (range 5-129) months, all 26 @entity1 were still alive. CONCLUSION: Multicystic @entity298 appears to be a distinct @entity298 , where long-term survival may be achieved through cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.

title: Multi-institutional experience of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['multicystic tumours']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['grade III or IV complications']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['subtype of peritoneal mesothelioma', 'peritoneal mesothelioma']

answer: @entity298 :: (MESH:D010538,Disease) :: ['diffuse intra-abdominal multicystic peritoneal mesothelioma']


abstract: BACKGROUND: @entity234 ( @entity234 ) is an @entity66 in some areas of Iran. A cross- sectional study was conducted for sero-epidemiological survey of @entity234 ( @entity234 ) in Baft district from Kerman Province, southeast of Iran. METHODS: Blood samples were collected from @entity1 up to 12 years old and 10% of adult population from Baft villages with a multi-stage randomized cluster sampling. In addition, blood samples were collected from 30 domestic @entity235 from the same areas. All the collected blood samples were tested by direct agglutination test (DAT) for the detection of anti- @entity13556 antibodies in both @entity1 and @entity235 using the cut-off value of >= 1:3200 and >= 1:320, respectively. Parasitological, molecular, and pathological were performed on infected @entity235 . Chi-square and Fisher exact tests were used to compare sero-prevalence values. RESULTS: From 1476 collected human serum samples, 23 (1.55%) showed anti- @entity13556 antibodies at titers of 1:800 and 1:1600 whereas 14 (0.95%) showed anti- @entity13556 infantum antibodies at titers of >= 1:3200. No statistically significant difference was found between male (1.18%) and female (0.69%) sero-prevalence (P=0.330). @entity1 of 5-8 years showed the highest sero-prevalence rate (3.22%). Seven out of 30 domestic @entity235 (23%) showed anti- @entity13556 antibodies at titers >= 1:320. @entity13556 was identified in five infected @entity235 by nested - PCR assay. CONCLUSION: It seems that @entity234 is being endemic in southern villages of Baft district, southeast of Iran.

title: Epidemiological aspects of XXXX in baft district, kerman province, southeast of iran.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'Children']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['endemic disease']

entities_list: @entity234 :: ('MESH:D007898', 'Disease') :: ['VL', 'kala-azar', 'visceral leishmaniasis', 'Visceral leishmaniasis']

entities_list: @entity13556 :: ('5671', 'Species') :: ['Leishmania infantum', 'Leishmania']

answer: @entity234 :: (MESH:D007898,Disease) :: ['visceral leishmaniasis']


abstract: Psychological stress is associated with an increased expression of markers of @entity32 , and there is a growing literature describing a link between periodontal pathogens and systemic @entity32 . The hypothesis of the present work is that exposing @entity19 to the social stressor, called social disruption (SDR), would enhance the inflammatory response to lipopolysaccharide (LPS) derived from the oral pathogen, @entity2523 . @entity19 were exposed to SDR for 2h per day on 6 consecutive days. On the morning following the last cycle of SDR, @entity19 were tested for @entity148 -like behavior in the open field test and novel object test. The @entity19 were sacrificed the following day and their spleens harvested. Spleen cells were stimulated with LPS derived from @entity2523 in the absence or presence of increasing doses of @entity2819 . Social disruption resulted in @entity148 -like behavior, and the production of @entity635 and @entity637 was significantly higher in spleen cells from @entity19 exposed to SDR in comparison to levels from non-stressed control @entity19 . In addition, the viability of spleen cells from @entity19 exposed to SDR was significantly greater than the viability of cells from non-stressed control @entity19 , even in the presence of high doses of @entity2819 . The use of cultures enriched for @entity3804 + cells indicated that the stressor was affecting the activity of splenic myeloid cells. This study demonstrates that social stress enhances the inflammatory response to an oral pathogen and could provide a critical clue in the reported associations between stress, @entity32 , and oral pathogens.

title: Social stress enhances XXXX and @entity637 production by @entity2523 lipopolysaccharide-stimulated @entity3804 + cells.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['peripheral inflammation', 'inflammation']

entities_list: @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone']

entities_list: @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']

answer: @entity635 :: (16176(Tax:10090),Gene) :: ['IL-1beta']


abstract: The status of @entity876 and the @entity4357 3-kinase-AKT (PI3K-AKT) signaling pathway was investigated in 132 @entity1204 , including endometrioid @entity1204 , @entity1204 , and mixed @entity4348 . Results were compared with the clinicopathologic parameters associated with prognosis, @entity1 ' follow-up, and other genetic alterations found frequently in these @entity5 . Molecular genetic differences between low-grade and high-grade @entity4348 were encountered; ie, @entity10160 mutations were detected in 26 and 34% of cases, respectively. We found @entity876 alterations in only 17% of high-grade @entity4348 . In contrast, non- @entity4348 had a higher frequency of @entity876 alterations (54%), @entity10160 mRNA overexpression (45%), and exon 20 @entity10160 mutations (21%). In the mixed @entity4348 , the most frequent alterations were @entity876 (50%) and @entity10160 (44%) mutations, followed by @entity983 mutations (38%). In some cases, @entity876 and @entity10160 alterations coexisted, but they rarely coexisted with the @entity983 mutations. Our findings suggest that the @entity10160 mutations are frequent events in @entity1204 of any histological type. However, location of the @entity10160 mutations, either in exon 9 or exon 20, varies significantly according to the histologic grade and type of @entity189 . @entity189 with exon 20 @entity10160 mutations or @entity10160 mRNA overexpression were often high-grade @entity189 associated with @entity3 ; in contrast, @entity5 that carried exon 9 mutations were more likely to be @entity189 . The Kaplan-Meier analysis suggested that @entity876 alterations (strong immunoexpression or mutations) conferred a worse prognosis (P=0.000). Although alterations in the PI3K-AKT signaling pathway alone did not influence overall survival, @entity1 with deregulated PI3K-AKT pathway ( @entity10160 and/or @entity983 alterations) and @entity876 alterations had shorter survival (P=0.000) than @entity1 with only @entity876 alterations. Such a relationship was lost when we considered exon 9 @entity10160 mutations. Our results contribute to further characterize the molecular genetic model for @entity1478 .

title: Concomitant PI3K-AKT and @entity876 alterations in XXXX are associated with poor prognosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['non-endometrioid endometrial carcinomas', 'endometrial carcinomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['low-grade carcinomas', 'carcinomas', 'Carcinomas', 'carcinoma']

entities_list: @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial carcinogenesis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['myometrial invasion']

entities_list: @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid adenocarcinomas', 'endometrioid adenocarcinomas-non-endometrioid adenocarcinomas']

entities_list: @entity4357 :: ('MESH:D010716', 'Chemical') :: ['phosphatidylinositol']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinomas']


abstract: Proinflammatory responses induced by @entity3964 @entity4495 (GPIs) are thought to be involved in @entity311 pathogenesis. In this study, we investigated the role of MAPK-activated protein kinase 2 (MK2) in the regulation of @entity5 @entity39 factor-alpha (TNF-alpha) and interleukin (IL)-12, two of the major inflammatory cytokines produced by macrophages stimulated with GPIs. We show that MK2 differentially regulates the GPI-induced production of TNF-alpha and IL-12. Although TNF-alpha production was markedly decreased, IL-12 expression was increased by 2-3-fold in GPI-stimulated MK2(-/-) macrophages compared with @entity164 ( @entity164 ) cells. MK2(-/-) macrophages produced markedly decreased levels of TNF-alpha than @entity164 macrophages mainly because of lower mRNA stability and translation. In the case of IL-12, mRNA was substantially higher in MK2(-/-) macrophages than @entity164 . This enhanced production is due to increased NF-kappaB binding to the gene promoter, a markedly lower level expression of the transcriptional repressor factor c-Maf, and a decreased binding of GAP-12 to the gene promoter in MK2(-/-) macrophages. Thus, our data demonstrate for the first time the role of MK2 in the transcriptional regulation of IL-12. Using the protein kinase inhibitors @entity1441 and @entity5732 , we also show that the ERK and p38 pathways regulate TNF-alpha and IL-12 production, and that both inhibitors can reduce phosphorylation of MK2 in response to GPIs and other toll-like receptor ligands. These results may have important implications for developing therapeutics for @entity311 and other @entity166 .

title: MAPK-activated protein kinase 2 differentially regulates @entity3964 @entity4495 -induced production of XXXX @entity39 factor-{alpha} and interleukin-12 in macrophages.

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum']

entities_list: @entity4495 :: ('MESH:D017261', 'Chemical') :: ['glycosylphosphatidylinositols']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: OBJECTIVE: To map @entity519 areas in arthritic synovium and to establish the relevance of low @entity26 levels to the phenotype of synovial fibroblasts, with special focus on bone degradation. METHODS: To analyze the distribution of @entity519 in @entity2720 , the @entity519 marker @entity32624 was administered to @entity19 with @entity1753 ( @entity1753 ). To evaluate the effect of @entity519 on @entity309 synovial fibroblasts (RASFs), reverse suppression subtractive hybridization and complementary DNA array were used. Real-time polymerase chain reaction, Western blotting, and immunohistochemistry were used to evaluate the expression of inhibitor of DNA binding/differentiation 2 ( @entity29096 ). To investigate the function of @entity29096 in RASFs, cells were transfected either with @entity29096 vector or with @entity29096 -specific small interfering RNA. RESULTS: @entity32624 staining showed the presence of @entity519 in @entity2720 , particularly at sites of synovial invasion into bone. Differential expression analysis revealed that @entity29096 was strongly induced by @entity519 in RASFs. Immunohistochemical analysis of @entity1753 @entity19 synovium and @entity1 @entity309 synovium showed a strong expression of @entity29096 by RASFs at sites of synovial invasion into bone. Overexpression of @entity29096 in RASFs significantly induced the expression of several factors promoting osteoclastogenesis. The biologic relevance of the potent osteoclastogenesis-promoting effects was shown by coculture assays of @entity29096 -overexpressing RASFs with bone marrow cells, leading to an increased differentiation of osteoclasts from bone marrow precursors. CONCLUSION: The data show that @entity519 conditions are present at sites of @entity32 and synovial invasion into bone in arthritic synovium. @entity519 -induced @entity29096 may contribute to joint destruction in @entity309 @entity1 by promoting synovial fibroblast-dependent osteoclastogenesis.

title: Inhibitor of DNA binding/differentiation 2 induced by XXXX promotes synovial fibroblast-dependent osteoclastogenesis.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['collagen-induced arthritis', 'CIA']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['Hypoxia', 'hypoxic', 'hypoxia']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthritic joints']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: Serum @entity251 (T) and @entity586 ( @entity587 ) were measured by a sensitive and reliable radioimmunoassay in 42 normal subjects and 33 age-matched @entity1 with @entity263 . The mean +/- s.e. for serum @entity251 in normal subjects was 16.74 +/- 0.76nM and the corresponding value for @entity1 with @entity189 was 20.94 +/- 1.48nM. Statistical analysis of the results showed a significant increase in T level in @entity1 with @entity263 (P less than 0.01). In contrast, there was no difference in @entity587 concentration between the two groups, values being 2.43 +/- 0.09 and 2.06 +/- 0.09nM for normal subjects and @entity1 respectively. The means +/- s.e. for T/ @entity587 ratio in controls and @entity1 were 6.8 +/- 0.2 and 12.8 +/- 1.3 respectively. The difference was highly significant (P less than 0.001). The wide range of variation for T in @entity1 with @entity189 would suggest that although mean T is higher in these @entity1 , this measurement alone is of little practical value, whereas T/ @entity587 ratio is a more reliable parameter in evaluating the @entity342 changes in these @entity1 . The significance of these findings in relation to the aetiology of the disease is discussed.

title: Serum @entity251 and XXXX in @entity263 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['carcinoma of the prostate']

entities_list: @entity586 :: ('MESH:D013196', 'Chemical') :: ['dihydrotestosterone']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity586 :: (MESH:D013196,Chemical) :: ['dihydrotestosterone']


abstract: INTRODUCTION: There is a growing interest in the use of @entity1 -reported outcomes to provide a more @entity1 -centered view on treatment. Forgetting the artificial joint can be regarded as the goal in joint arthroplasty. The goals of the study were to describe changes in joint awareness in the artificial joint after total knee arthroplasty (TKA), and to determine which factors among @entity158 , knee range of motion (ROM), quadriceps strength, and functional ability affect joint awareness after TKA. HYPOTHESIS: @entity1 undergoing TKA demonstrate changes in joint awareness and joint awareness is associated with @entity158 , knee ROM, quadriceps strength, and functional ability. @entity1 AND METHODS: This prospective cohort study comprised 63  individuals undergoing TKA, evaluated at 1, 6, and 12  months postoperatively. Outcomes included joint awareness assessed using the Forgotten Joint Score (FJS), @entity158 score, knee ROM, quadriceps strength, and functional ability. RESULTS: Fifty-eight individuals completed all postoperative assessments. All measures except for knee extension ROM improved from 1 to 6  months. However, there were no differences in any measures from 6 to 12  months. FJS was affected most greatly by @entity158 at 1  month and by quadriceps strength at 6 and 12  months. DISCUSSION: @entity1 following TKA demonstrate improvements in joint awareness and function within 6  months after surgery, but reach a plateau from 6 to 12  months. Quadriceps strength could contribute to this plateau of joint awareness. LEVEL OF EVIDENCE: Prospective cohort study, IV.

title: Joint awareness after total knee arthroplasty is affected by XXXX and quadriceps strength.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patient', 'Patients']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: A novel in-package ozonation device was evaluated for its efficacy in inactivating three microorganisms (viz., @entity16085 , attenuated @entity2491 , and @entity526 O157:H7) on tomatoes and for its effect on fruit quality. The device produced @entity1787 inside sealed film bags, reaching a concentration of 1,000 ppm within 1 min of activation. The three bacterial cultures were inoculated onto either the smooth surface or the stem scar areas of the tomatoes, which were then sealed in plastic film bags and subjected to in-package ozonation. @entity16085 on tomatoes was reduced to nondetectable levels within 40 s of treatment on the @entity523 surface, with inactivation of ca. 4 log CFU per fruit on the stem scar area. An increase in treatment time did not result in a proportional increase in bacterial reduction. For @entity526 O157:H7 and @entity2491 , there was little difference (<1 log) in the effectiveness of the system when comparing surface and scar-inoculated bacteria. Both bacteria were typically reduced by 2 to 3 log CFU per fruit after 2- to 3-min treatments. No negative effects on fruit color or texture were observed during a 22-day posttreatment storage study of @entity1787 -treated tomatoes. These results suggest that the three bacteria responded differently to ozonation and that in-package ozonation may provide an alternative to chemical sanitizers commonly used by the industry.

title: Inactivation of XXXX , @entity2491 , and @entity526 O157:H7 on surface and stem scar areas of tomatoes using in-package ozonation.

entities_list: @entity2491 :: ('90371', 'Species') :: ['Salmonella Typhimurium', 'Salmonella']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

entities_list: @entity16085 :: ('1642', 'Species') :: ['Listeria innocua', 'L. innocua']

answer: @entity16085 :: (1642,Species) :: ['Listeria innocua']


abstract: BACKGROUND: The mutations in the @entity35351 ( @entity35351 ) and @entity29515 ( @entity29515 ) genes have been identified in @entity1 with @entity6750 ( @entity6750 ). This study reports a set of dizygotic twins with @entity6750 due to the mutations in the @entity29515 / @entity35351 system. METHODS: The dizygotic twins, a @entity1 and a @entity1 , both aged 7 years, were born to euthyroid nonconsanguineous parents; they were diagnosed with @entity6750 at neonatal screening and were enrolled in this study. The @entity35351 , @entity29515 , @entity15529 ( @entity15529 ), @entity5787 ( @entity5787 ), and @entity5010 ( @entity5010 ) genes were considered for mutation screening. Genomic DNA was extracted from peripheral blood leukocytes, and Sanger sequencing was used to screen for the mutations in the exon fragments. Family members of the @entity1 were also enrolled and evaluated. RESULTS: The fraternal twins each harbored a single heterozygous mutation, including @entity35352 ( @entity35353 ) in the @entity1 inherited from the paternal @entity35351 allele and @entity35354 ( @entity35355 ) in the @entity1 from the maternal @entity29515 allele. The two mutations have been previously reported. The @entity1 showed @entity1374 and a little calcification in the left lobe, while the @entity1 's thyroid gland was severely underdeveloped and the @entity1 had obvious complications due to irregular treatment. The germline mutations from this family were consistent with an autosomal recessive inheritance pattern. No mutations in the @entity15529 , @entity5787 , and @entity5010 genes were detected in this study. CONCLUSIONS: The inactivating mutations in the @entity35351 ( @entity35353 ) and @entity29515 ( @entity35355 ) genes were identified in a set of dizygotic twins with @entity6750 . The @entity1 was more severe in several aspects than her brother. The similar genetic defect resulted in very different outcomes.

title: Heterozygous Mutations of the @entity35351 and XXXX Genes in Dizygotic Twins with @entity6750 .

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients', 'boy']

entities_list: @entity5787 :: ('7173', 'Gene') :: ['TPO', 'thyroid peroxidase']

entities_list: @entity5010 :: ('7253', 'Gene') :: ['TSHR', 'thyrotropin receptor']

entities_list: @entity35351 :: ('405753', 'Gene') :: ['DUOXA2', 'dual oxidase maturation factor 2']

entities_list: @entity6750 :: ('MESH:D003409', 'Disease') :: ['CH', 'congenital hypothyroidism']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['enlarged thyroid lobes']

answer: @entity29515 :: (50506,Gene) :: ['DUOX2']


abstract: We examined silent @entity741 in @entity6 by treadmill exercise testing. There were 28 @entity6 @entity1 and 64 @entity6 @entity1 without @entity951 , with a mean age of 59 +/- 11 years. Symptom-limited treadmill exercise testing was performed, and we used the electrocardiogram during exercise and immediately after exercise for judgement. @entity308 was defined as positive if there was at least 0.1 mV of ST @entity308 80 ms from the J point. It was defined as negative if max heart rate (HR) was more than 80% of target HR and there was no significant ST @entity308 . It was defined as equivocal if there was no significant ST @entity308 but max HR was less than 80% of target HR. In 92 @entity6 , 21 @entity1 (23%) showed positive ST @entity308 , 35 (38%) showed negative ST @entity308 , 36 (39%) showed equivocal ST @entity308 . In 56 @entity6 exclusive of treadmill equivocal @entity1 , 38% of @entity1 showed positive ST @entity308 . Treadmill positive @entity6 had a significantly higher rate of smokers, @entity1 with @entity101 , and a higher @entity412 level as compared with treadmill negative @entity6 . Coronary arteriography, which was performed in six treadmill positive @entity6 , revealed @entity3979 of more than 75% in four @entity1 .

title: [Silent XXXX in @entity6 --by treadmill exercise testing].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'men']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['ST segment depression', 'depression']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

answer: @entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']


abstract: Etiopathogenesis of inflammatory processes of the urinary tract, mainly of obstructive @entity3551 and chronic @entity2885 , is reviewed. The most frequent cause of obstruction is renal @entity9279 ; in the pathogenesis of chronic @entity2885 the following factors are of great importance: renal and @entity154 , @entity1290 , pregnancy, bladder instrumentation as catheterisation, etc. We analyzed 2101 random by selected hospital @entity1 and found significant @entity793 in 740 (35 p.c.) of them. The most frequent cultured bacteria which caused @entity293 were: Proteus strains (29.3 p.c), @entity526 (27.5 p.c.) and Pseudomonas aerug. (13,6 p.c.) Significant @entity793 was more frequent in @entity1 than in @entity1 , but @entity526 was more frequent in @entity1 (71.5 p.c.). Proteus, @entity4005 were more frequent in @entity1 . It should be noted that the majority of @entity1 with positive urinary cultures were subjects treated at the Urology Department; and that @entity1 prevailed. This is the reason why our results related to the causing bacteria differed from those found in general population.

title: [Etiopathogenesis of the inflammation process and the incidence of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['urethral anomalies']

entities_list: @entity793 :: ('MESH:D001437', 'Disease') :: ['bacteriuria']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['renal stones']

entities_list: @entity4005 :: ('MESH:D007710', 'Disease') :: ['Pseudomonas and Klebsiella']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary infection']

entities_list: @entity9279 :: ('MESH:D020347', 'Disease') :: ['calculosis']

answer: @entity293 :: (MESH:D014552,Disease) :: ['urinary tract infections']


abstract: INTRODUCTION: @entity14 is the third most common @entity5 and the second cause of @entity204 due to @entity5 in developed countries. Approximately 10% of @entity1 with this diagnosis develop lung @entity3 , although only 2-4% of them have lung @entity3 as the only extension location. OBJECTIVE: To study the prognostic factors of @entity14 . @entity1 AND METHODS: A retrospective observational study was conducted on 30 @entity1 with @entity14 who were operated on in our hospital between January 2003 and December 2007. RESULTS: Of the 30 @entity1 who received surgery, 19 were males (63%) and 11 were female (37%), with a mean age of 63.37 years (range 35-82 years). The mean overall survival was 36.64 months (range 18.58-54.70 months). A total of 13 pre-, intra-, and postoperative parameters were used in the statistical analysis. In the univariate analysis, the number of @entity3 greater than 3 (P=.051), whether they were bilateral (P=.001), or bilobar (P<.001), were statistically significant factors of a poor prognosis. In the multivariate analysis, only being bilobar was shown to be a statistically significant factor of a poor prognosis (P=.005). CONCLUSIONS: In our @entity1 series affected by @entity14 , the number of @entity3 greater than three, whether they are bilobar and bilateral, are factors of a poor prognosis. These factors should be taken into account in the follow-up of these @entity1 , although prospective studies with a larger number of @entity1 are required to confirm these findings.

title: [Prognostic factors of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal carcinoma lung metastases', 'colorectal cancer lung metastases']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer lung metastases']


abstract: INTRODUCTION: @entity14244 ( @entity14244 ) is the commonest serious complication of monochorionic (MC) twin pregnancies, with perinatal mortality rates of up to 90% if untreated. This study aimed to review the perinatal and perioperative outcomes of MC twin pregnancies treated for @entity14244 by fetoscopic laser photocoagulation (FLP) since the introduction of the procedure at KK @entity1 's and @entity1 's Hospital, Singapore, in 2011. METHODS: This was a retrospective review of five consecutive @entity1 who underwent FLP of placental anastomoses for @entity14244 at KK @entity1 's and @entity1 's Hospital from June 2011 to March 2014. FLP was offered to @entity1 who were diagnosed with @entity14244 of at least Quintero Stage II before 26 weeks of gestation. Main outcome measures were perioperative complications and perinatal survival rates. RESULTS: Five sets of MC twin pregnancies underwent FLP during the study period - three pregnancies were diagnosed with @entity14244 Stage III and two pregnancies were diagnosed with @entity14244 Stage II. Median gestational age at initial presentation, and at the times of laser photocoagulation and delivery were 19 (range 17-20) weeks, 20 (range 19-23) weeks and 29 (range 28-34) weeks, respectively. One @entity1 had @entity548 into the amniotic cavity intraprocedurally. Overall, perinatal survival rate, double- @entity1 survival rate and survival rate for at least one twin were 60% (6/10 fetuses), 40% (2/5 twins) and 80% (4/5 twins), respectively. CONCLUSION: FLP is a feasible treatment for @entity14244 , with minimal maternal complications. Perinatal survival rates of this @entity1 group, managed at our centre, were comparable to those of international centres.

title: Fetoscopic laser photocoagulation in XXXX : experience from a single institution.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Children', 'Women', 'patient', 'infant']

entities_list: @entity14244 :: ('MESH:D005330', 'Disease') :: ['Twin-to-twin transfusion syndrome', 'TTTS']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity14244 :: (MESH:D005330,Disease) :: ['twin-to-twin transfusion syndrome']


abstract: Prolonged exposure of pancreatic islets to free @entity1718 (FFAs) inhibits @entity413 -stimulated insulin secretion (GSIS) in vitro. However, FFA inhibition of GSIS has not been clearly demonstrated in vivo. We examined the in vivo effect of prolonged elevation of plasma FFAs on GSIS using a two-step hyperglycemic clamp in @entity35 treated with a 48-h intravenous infusion of either 20% Intralipid plus heparin (INT) (5 microl/min plus heparin, 0.1 U/min; n = 8), @entity3952 ( @entity17346 ) (1.3 microEq/min; n = 6), saline ( @entity2697 ) (n = 6), or bovine serum albumin (BSA) (vehicle for @entity17346 ; n = 5). Because there was no difference in any of the parameters between BSA and SAL @entity35 , these groups were combined as control @entity35 (CONT) (n = 11). At the end of the 48-h @entity17346 /INT/CONT infusions, after an overnight fast, plasma @entity413 was clamped for 2 h at 13 mmol/l and for another 2 h at 22 mmol/l. Preclamp plasma FFAs were elevated twofold (P < 0.01) versus CONT with both INT and @entity17346 (NS, INT vs. @entity17346 ). Preclamp @entity413 , insulin, and C-peptide levels were higher in INT than in CONT @entity35 (P < 0.05), suggesting insulin resistance, but they were not different in @entity17346 and CONT @entity35 . The insulin and C-peptide responses to the rise in plasma @entity413 from basal to 13 mmol/l were lower in @entity17346 (336 +/- 72 pmol/l and 1.2 +/- 0.1 nmol/l, P < 0.01 and P < 0.05, respectively) than in CONT (552 +/- 54 and 1.9 +/- 0.1) @entity35 , but they were not different between CONT and INT @entity35 (648 +/- 150 and 2.0 +/- 0.4). The insulin and C-peptide responses to the rise in plasma @entity413 from 13 to 22 mmol/l were lower in both INT (1,188 +/- 204 pmol/l and 3.0 +/- 0.3 nmol/l, P < 0.01 and P < 0.001) and @entity17346 (432 +/- 60 and 1.7 +/- 0.2, P < 0.001 vs. CONT or INT) @entity35 than in CONT @entity35 (1,662 +/- 174 and 5.0 +/- 0.6). In summary, 1) both INT and @entity17346 decreased GSIS in vivo in @entity35 , and 2) the impairing effect of INT on GSIS was less than that of @entity17346 , which might be due to the different type of @entity844 (mostly polyunsaturated in INT versus monounsaturated as @entity17346 ) and/or to differential effects of INT and @entity17346 on insulin sensitivity. In conclusion, prolonged elevation of plasma FFAs can desensitize the insulin secretory response to @entity413 in vivo, thus inducing a beta-cell defect that is similar to that found in type 2 @entity6 .

title: Prolonged elevation of plasma free @entity1718 desensitizes the insulin secretory response to @entity413 in vivo in XXXX .

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: INTRODUCTION: Increasing evidence suggests that @entity32 and increased macrophage activity have a central role in pathogenesis of @entity731 . It is shown that chitotriosidase ( @entity32875 ) is a marker of macrophage activity in @entity731 , and is found associated with severity of @entity731 . There is no data about @entity32875 activity of hemodialysis @entity1 in the literature. Thus, we hypothesized that in hemodialysis @entity1 , @entity32875 levels might be a novel biomarker in early @entity731 . METHODS: Forty-five hemodialysis @entity1 were included in the study (age: 61.93        13.34). @entity121 ( @entity121 ) was evaluated with high-resolution B-mode ultrasonography. Biomarker levels were measured in serum of @entity1 . FINDINGS: We found positive correlation among @entity121 , age (R: 0.426, P: 0.004) and, @entity32875 value (R: 0.462, P: 0.001) in spearman correlation analysis. When age, @entity1851 , @entity1011 , P, @entity2313 , @entity32875 were chosen as measures that can effect @entity121 in multiple regression model, @entity121 level was related with @entity32875 (Beta: 0,396, P: 0.012) and age (Beta: 0,313 P: 0,048) independently. DISCUSSION: In conclusion, this is the first report showing that serum @entity32875 level was related independently with carotid @entity121 in hemodialysis @entity1 . This biomarker might have an unknown role in the development of @entity731 during @entity5507 .

title: Chitotriosidase as a novel biomarker of early XXXX in hemodialysis @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'atherosclerotic lesion', 'atherosclerotic plaque']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['Intima media thickness', 'IMT']

answer: @entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']


abstract: BACKGROUND: Biomarkers in @entity0 provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined the possible correlation between @entity5 stem cell (CSC)-like markers ( @entity5439 , paired box gene 2 protein ( @entity5449 ), @entity5960 , and a new membrane @entity172 receptor ( @entity21841 ( @entity21841 )) in @entity9962 with known clinicopathological parameters, @entity5 recurrence, and expression of some known biomarkers. METHODS: In 74 @entity9962 , we investigated the protein expression of these molecular markers by immunohistochemistry, and their associations with known clinicopathological parameters, @entity5 recurrence, and expression of some known biomarkers. We studied the interrelationship between the expressions of these proteins. RESULTS: @entity5439 , a putative CSC marker, was positively related to @entity5 size, @entity5 stage, and lymph node @entity3 . @entity5449 was negatively correlated with @entity5 recurrence. @entity5960 , one of the breast CSC markers, was an indicator of @entity5 recurrence. @entity21841 was associated with hormone receptors. Despite the correlation between @entity21841 and the nuclear @entity172 receptor, the expression was dependent. Positive staining of @entity21841 in @entity5 displayed a significant association with high @entity1722 expression and a tendency for @entity5 recurrence. A positive relationship between @entity21841 and @entity5439 existed. CONCLUSION: Detecting the expression of @entity5439 , @entity5449 , @entity5960 , and @entity21841 in @entity9962 may be of help in more accurately predicting the aggressive properties of @entity0 and determining the optimal treatment.

title: Expression of @entity5439 , @entity5449 , XXXX , and @entity21841 in @entity9962 .

entities_list: @entity5960 :: ('4072', 'Gene') :: ['ESA', 'epithelial specific antigen (ESA))']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity9962 :: ('MESH:D018270', 'Disease') :: ['invasive ductal breast carcinomas']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity21841 :: ('2852', 'Gene') :: ['GPR30', 'G-protein coupled receptor 30']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity5960 :: (4072,Gene) :: ['ESA']


abstract: Risk-taking behavior and @entity23 are core features of @entity162 . Whether they are part of the inherited aspect of the illness is not clear. We aimed to evaluate risk-taking behavior as a potential endophenotype for @entity162 , and its relationship with @entity23 and illness features. The Balloon Analogue Risk Task (BART) and Barratt Impulsiveness Scale-11 (BIS-11) were used to assess risk-taking behavior and @entity23 respectively in 30 euthymic @entity162 @entity1 ( @entity2403 ), their 25 asymptomatic first-degree relatives ( @entity2403 -R), and 30 @entity23 ( @entity23 ). The primary BART outcome measure was the behavioral adjustment score (number of pumps after trials where the balloon did not pop minus the number of pumps after trials where the balloon popped). @entity2403 (p < .001) and @entity2403 -R (p = .001) had similar and significantly lower adjustment scores than @entity23 . Only @entity2403 scored significantly higher on BIS-11 total (p = .01) and motor (p = .04) subscales than @entity23 . Neither the BART, nor @entity23 scores associated with illness features. A limitation of this study is medicated @entity1 and a heterogeneous @entity2403 -R were included. Riskiness may be a candidate endophenotype for @entity162 as it appears independently from illness features, presents similarly in @entity2403 and @entity2403 -R groups and differs from @entity23 .

title: Can risk-taking be an endophenotype for @entity162 ? A study on XXXX with @entity162 type I and their first-degree relatives.

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['impulsivity', 'healthy controls', 'HC']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'bipolar I', 'bipolar disorders']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Although Fas on @entity788 promotes autoimmune @entity6 in @entity19 , the role of Fas expression on kidney parenchymal cells during @entity792 is unknown. METHODS: To determine whether Fas on renal parenchymal cells promotes @entity8 , we compared apoptosis and pathology in Fas-intact and @entity24344 kidneys in an autoimmune milieu. For this purpose, we transplanted single, normal kidneys from MRL-++ (Fas-intact) @entity19 (3 months of age) into age-matched, congenic MRL-Faslpr ( @entity24344 ) recipients after @entity8 . These Fas-intact kidneys were compared with @entity8 . RESULTS: There is a progressive increase of @entity9699 on kidney-infiltrating cells and Fas and @entity9699 on renal parenchymal cells in MRL-++ kidneys during engraftment (0, 2, 4-6, and 8 weeks). By comparison, we detected an increase in @entity9699 in MRL-Faslpr kidneys (3 to 5 months of age), whereas Fas was not detectable. The engagement of T cells bearing @entity9699 with Fas expressing tubular epithelial cells (TECs) induced @entity16096 apoptosis in vitro. However, apoptosis and pathology were similar in kidneys (MRL-++, 8 weeks postengraftment vs. MRL-Faslpr, 5 months) with equivalent amounts of @entity9699 -infiltrating cells or @entity9699 TECs, regardless of Fas on renal parenchymal cells. CONCLUSION: The expression of Fas on renal parenchymal cells does not increase apoptosis or promote @entity8 in MRL-++ @entity19 . We speculate that the autoimmune milieu evokes mechanisms that mask, counter, or pre-empt Fas- @entity9699 -initiated apoptosis in MRL kidneys.

title: Fas on renal parenchymal cells does not promote XXXX in MRL @entity19 .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic islets']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Fas-deficient nephritic kidneys', 'removal of nephritic kidneys', 'autoimmune renal destruction', 'renal disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity24344 :: ('MESH:C535950', 'Disease') :: ['Fas-deficient']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']

answer: @entity792 :: (MESH:D001327,Disease) :: ['autoimmune nephritis']


abstract: UNASSIGNED: @entity731 is a chronic @entity32 with @entity731 containing inflammatory cells, including T-lymphocytes, dendritic cells (DCs) and macrophages that are responsible for progression and destabilization of @entity731 . Stressed cells undergoing necrosis release molecules that act as endogenous danger signals to alert and activate innate immune cells. In @entity731 tissue the number of DCs increases with the progression of the lesion and produce several inflammatory cytokines and growth factors. @entity15054 plays a crucial role in @entity32 . However, relationship of DCs and the role of @entity15054 with the stability of @entity731 have not been examined. In this study, we investigated the heterogeneity of the plaque DCs, myeloid ( @entity28930 and @entity28589 ) and plasmacytoid (pDCs), and examined the expression of @entity15054 and their co-localization with DCs in the plaques from symptomatic (S) and @entity10094 ( @entity10094 ) @entity1 with @entity543 . We found increased expression of HLA-DR, @entity17471 , and @entity15054 and decreased expression of @entity16014 and a-smooth muscle actin in S compared to @entity10094 @entity731 carotid plaques. Both @entity15054 and @entity17471 were co-localized suggesting increased expression of @entity15054 in plaque DCs of S compared to @entity10094 @entity1 . These data were supported by increased mRNA transcripts of @entity15054 and decreased mRNA transcripts of @entity16014 in carotid plaques of S compared to @entity10094 @entity1 . There was higher density of both @entity4897 + @entity28930 and @entity9820 + @entity28589 in the carotid plaques from @entity10094 compared to S @entity1 , where as the density of @entity26856 + pDCs were higher in the carotid plaques of S compared to @entity10094 @entity1 . These findings suggest a potential role of pDCs and @entity15054 in @entity731 vulnerability. Thus, newer therapies could be developed to selectively block @entity15054 for stabilizing @entity731 .

title: Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'inflammatory disease']

entities_list: @entity15054 :: ('54210', 'Gene') :: ['TREM-1', 'Triggering receptor expressed on myeloid cells (TREM)-1']

entities_list: @entity10094 :: ('MESH:D058070', 'Disease') :: ['asymptomatic', 'AS']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'Atherosclerosis', 'atherosclerotic plaques', 'atherosclerotic plaque']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis']

answer: @entity543 :: (MESH:D016893,Disease) :: ['Carotid Stenosis']


abstract: @entity35 osteoblasts were cultured for 4 and 5 days aboard a space shuttle and solubilized after a 24-h treatment with @entity3873 . The quantitative RT-PCR determined the mRNA levels of signaling molecules upstream and downstream Ras. The small GTPase is activated by @entity6370 exchange protein (GEF) and deactivated by GTPase-activating protein (GAP). When external stimuli are transduced into intracellular signals, various pathways are recruited: @entity2305 ( @entity2305 ) is associated with integrin-beta, and directs @entity669 phosphorylation of downstream substrates, including phospholipase C-gamma (PLC-gamma) and son of sevenless (SOS, a Ras GEF). The mRNA levels of @entity2305 and @entity30655 in the flight cultures were increased 150% and 250% of the ground controls. The SOS mRNA levels in the flight cultures were increased 520% and 320% of the ground controls. Signals via G protein-coupled receptors are transmitted through PLC-beta and Ras GRF (another Ras GEF). Activated Ras then stimulates Raf, mitogen-activated protein kinase (MAPK) cascades. The mRNA levels of Raf, extracellular signal-regulated protein kinase of MAPK family ( @entity2508 ), and PLC-beta were increased during spaceflight. @entity30656 expression in the flight cultures was increased twofold of the ground controls. Since @entity30656 deactivates @entity18588 , microgravity may suppress @entity18588 signals, regulating actin filament rearrangement. Microgravity signals may involve two pathways (G protein-coupled receptor-mediated pathway and @entity669 phosphorylation-mediated pathway) that activate Ras, Raf, and MAPK cascades in @entity35 osteoblasts.

title: Small GTPase Ras and @entity18588 expression in XXXX osteoblasts during spaceflight.

entities_list: @entity6370 :: ('CHEBI:61292', 'Chemical') :: ['guanine nucleotide']

entities_list: @entity3873 :: ('MESH:D002117', 'Chemical') :: ['1alpha,25 dihydroxyvitamin D(3)']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES:     Recent studies have identified recruitment of customers at the pharmacy counter as a limiter to successful provision of cognitive services in community pharmacies especially that of experienced customers with refill prescriptions. The aim of the paper is to gain insight into current problems of recruiting. METHODS: A qualitative study was conducted based on semi-structured interviews with 12 @entity1 in a project in 2010 aimed at optimising recruitment of experienced @entity565 @entity1 for the Inhaler Technique Assessment Service in Denmark. An ad hoc analysis was applied in order to interpret pharmacy staff perceptions of experienced @entity565 @entity1 in comparison with newly diagnosed @entity1 and to categorise the types of developed recruitment strategies as to whether they reflected a technical or everyday-life perspective on medicine. KEY FINDINGS: Effective recruitment processes were found to follow a generic pattern which consisted of a special type of opening question followed by providing a justification for the service. The @entity1 perceived that the main difference between experienced and newly diagnosed @entity1 was their degree of knowledge about their condition or correct inhaler technique. Most questions, and especially those related to reasons for motivating the customer to accept the service, were dominated by a professional technical understanding of medicine. In particular, follow-up justification based on a life-world perspective needs to be developed further. The identified type of communication might prevent some customers from accepting the service as they are not motivated by technical arguments but rather by how their daily symptoms can be relieved. CONCLUSIONS: Pharmacy staff should focus both on adequate opening questions as well follow-up justification when trying to recruit customers for cognitive services. The study might inform future studies on how to create new and more adequate strategies for recruitment of customers for relevant cognitive services in community pharmacies.

title: How to engage experienced medicine users at the counter for a pharmacy-based XXXX inhaler service.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: Delayed wound @entity446 may explain postoperative tissue and wound dehiscence in smokers, but the effects of smoking and smoking cessation on the cellular mechanisms remain unclear. Suction blisters were raised in 48 smokers and 30 never smokers. The fluid was retrieved and the epidermal roof was excised. Transepidermal water loss (TEWL) was measured after 2, 4, and 7 days. Then, the smokers were randomized to continuous smoking or abstinence with a transdermal @entity1239 patch or a placebo by concealed allocation. The sequence was repeated after 4, 8, and 12 weeks in all smokers and abstainers and in 6 never smokers. @entity5952 and @entity3334 levels in suction blister fluid were assessed by an enzyme-linked immunosorbent assay. Random-effects models for repeated measurements were applied and p< or =0.05 was considered significant. One week after wounding the TEWL was 17.20 (14.47-19.92) g/cm(2) hour (mean, 95% CI) in smokers and 13.89 (9.46-18.33) in never smokers (p<0.01). In abstinent smokers TEWL was 18.95 (15.20-22.70)(p<0.01, when compared with smokers). In smokers, @entity5952 was 36.4 (24.3-48.5) ng/mL (mean, 95% CI) and 15.2 (1.4-30.2) ng/mL in never smokers (p<0.01). Abstinent smokers' @entity5952 level was 21.2 ng/mL (6.6-43.0) (p=0.02, when compared with smokers). @entity3334 was unaffected by smoking and abstention. Transdermal @entity1239 patch did not affect any parameter. We conclude that smoking attenuates epidermal @entity446 and may enhance extracellular matrix degradation. Three months of abstinence from smoking does not restore epidermal @entity446 , whereas 4 weeks of abstinence normalizes suction blister @entity5952 levels. These findings suggest sustained impaired wound @entity446 in smokers and potential reversibility of extracellular matrix degradation.

title: Effect of smoking, abstention, and XXXX patch on epidermal @entity446 and collagenase in skin transudate.

entities_list: @entity5952 :: ('4317', 'Gene') :: ['MMP-8', 'Matrix metalloproteinase (MMP)-8']

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

answer: @entity1239 :: (MESH:D009538,Chemical) :: ['nicotine']


abstract: Externalizing behaviors (encompassing antisocial, impulsive, and substance use behaviors) are pervasive and impairing across a multitude of settings and developmental contexts. These behaviors, though often investigated separately, are highly comorbid. Prenatal @entity286 exposure in interaction with various genetic influences has predicted later externalizing behavior, and recent evidence supports investigating sex differences in these patterns. In the current study, we extend this work by (a) examining two functional genetic markers in the @entity935 system: the transporter gene ( @entity7712 ) and the @entity935 receptor D4 gene (DRD4) in interaction with prenatal @entity286 exposure to predict a latent composite of externalizing behavior and (b) testing whether these patterns differ by sex of youth in a community sample of adolescents (n=176). The relatively small sample is partially offset by high quality, multi-method prospective measurement. We assessed prenatal @entity286 exposure using prospective repeated @entity4874 -corrected reports and externalizing behaviors were assessed utilizing multiple measures across three waves. The interaction between @entity7712 (but not DRD4) and prenatal @entity286 exposure was statistically significant in @entity1 , and patterns appeared to differ by sex. Risk for externalizing behaviors for exposed @entity1 increased linearly as a function of the 10r @entity7712 allele. For exposed @entity1 , there was a trend such that @entity7712 heterozygotes had a marginally higher risk than homozygotes. This pattern was not explained by passive gene-environment correlation. Elucidating sex-specific pathways through which early adverse exposures and genetic susceptibilities contribute to externalizing behavior can inform early targeted prevention efforts for those @entity1 at highest risk.

title: Do XXXX gene variants and prenatal smoking interactively predict youth externalizing behavior?

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity4874 :: ('MESH:D003367', 'Chemical') :: ['cotinine']

answer: @entity935 :: (MESH:D004298,Chemical) :: ['dopamine']


abstract: Dynamic exercise increases the number of beta-adrenergic receptors in mixed lymphocytes by a mechanism that is incompletely understood. In a set of in vivo studies, we have investigated the effects of dynamic exercise on the subset distribution of circulating lymphocytes and on the number of beta-adrenergic receptors in each of these subsets in two groups of @entity1 . In healthy subjects, exercise increased plasma @entity1063 and @entity1425 and caused @entity6113 . Whereas the number of Thelper cells increased only modestly, the number of Tsuppressor/cytotoxic and natural killer cells more than tripled. The number of beta-adrenergic receptors varied among subsets but was not significantly altered by dynamic exercise in any subset except natural killer cells (35% increase, p = 0.0302). In a group of @entity1 with @entity712 , dynamic exercise increased plasma @entity1063 but did not alter plasma @entity1425 and did not cause significant @entity6113 . We did not detect any significant alterations of circulating leukocyte subsets or beta-adrenergic receptors in any of these subsets after exercise. A combined analysis of healthy @entity1 and @entity712 @entity1 revealed a significant correlation between increases in plasma @entity1425 and increases in circulating lymphocytes. We conclude that the exercise-induced increase in beta-adrenergic receptors of mixed lymphocytes is predominantly caused by a redistribution of circulating cell subsets that differ in their beta-adrenergic receptor number. This appears to be mediated by @entity1425 rather than @entity1063 .

title: Beta-adrenergic receptors in lymphocyte subsets after exercise. Alterations in normal individuals and XXXX with @entity712 .

entities_list: @entity6113 :: ('MESH:D008218', 'Disease') :: ['lymphocytosis']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'heart failure']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To characterize the @entity731 risk factors in the progression of subclinical @entity731 in @entity1 with juvenile-onset @entity1252 ( @entity1252 ). METHODS: This was a longitudinal study of 76 @entity1 with juvenile-onset @entity1252 . Carotid arteries were evaluated using ultrasonography at baseline and at followup visits at 6-month intervals over the 6-year study period. Clinical and laboratory parameters, disease activity, treatment, and traditional risk factors for @entity731 were evaluated. Data were analyzed using generalized estimating equations. RESULTS: The mean+/-SD age of the @entity1 at baseline was 15.01+/-3.48 years and the mean+/-SD disease duration was 2.65+/-2.5 years. The mean+/-SD duration of followup was 3.74+/-1.24 years. The mean+/-SD @entity121 ( @entity121 ) of the common carotid arteries differed significantly between the @entity1 and control (n=38) groups (0.63+/-0.08 mm versus 0.54+/-0.06 mm; P<0.001). The presence of @entity2905 at diagnosis and at baseline and higher levels of serum @entity1011 and @entity1851 at baseline were positively associated with progression of carotid @entity121 (P=0.006, P=0.043, P=0.037, and P=0.049, respectively). In multivariate analysis, only @entity2905 at baseline and at diagnosis were consistently associated with progression of @entity121 (P=0.012 and P=0.045, respectively). CONCLUSION: In @entity1 with juvenile-onset @entity1252 , some nontraditional risk factors for the progression of subclinical @entity731 were identified. @entity2905 was the only independent risk factor for the progression of @entity121 . The pathogenic mechanisms warrant further investigation.

title: XXXX is a risk factor in the progression of carotid @entity121 in juvenile-onset @entity1252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2905 :: ('MESH:D008231', 'Disease') :: ['Lymphopenia', 'lymphopenia']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerosis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity2905 :: (MESH:D008231,Disease) :: ['Lymphopenia']


abstract: Intentional @entity353 is an important component of treatment for overweight @entity1 with @entity164 2 @entity6 , but the effects on bone density are not known. We used data from the Look AHEAD trial to determine the impact of an intensive lifestyle @entity353 intervention (ILI) compared with @entity6 support and education (DSE) on changes in @entity79 ( @entity79 ) over 12 months. Overweight and @entity28 adults with @entity164 2 @entity6 were randomly assigned to ILI or DSE. In a substudy of @entity79 conducted at 5 of 16 clinical centers, hip, spine, and whole body dual X-ray absorptiometry scans were obtained at baseline and 1-year later on 642 of 739 ILI and 632 of 740 DSE @entity1 . At baseline, mean age was 58.4 years, and average body mass index was 35.2 kg/m(2). Total hip @entity79 T-score was <-2.5 in 1% and <-1.0 in 8%. At 1 year, @entity353 was greater in ILI than DSE (-8.6% versus -0.7%), and glycemic control and fitness were also improved. @entity604 over 1 year was greater in ILI at the total hip (-1.4% versus -0.4%; p < 0.001) and femoral neck (-1.5% versus -0.8%; p = 0.009), but change in @entity79 for the lumbar spine and whole body did not differ between groups. In ILI, @entity604 at the total hip was independently associated with @entity353 in @entity1 and @entity1 and with poorer glycemic control in @entity1 , but was not associated with changes in fitness. One year of an intensive lifestyle intervention in adults with @entity164 2 @entity6 , resulting in @entity353 , was associated with a modest increase in hip @entity604 despite improved fitness and glycemic control.

title: Effect of 1 year of an intentional @entity353 intervention on XXXX in @entity164 2 @entity6 : results from the Look AHEAD randomized trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'men']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['Bone loss', 'bone loss']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

answer: @entity79 :: (MESH:D001847,Disease) :: ['bone mineral density']


abstract: BACKGROUND: @entity6 and @entity101 are devastating, deadly, and costly conditions that are very common in seniors. Controlling @entity101 in seniors with @entity6 dramatically reduces @entity101 . However, blood pressure (BP) must be lowered carefully because seniors are also susceptible to low BP and attendant harms. Achieving "optimal BP control" (ie, avoiding both undertreatment and overtreatment) is the ultimate therapeutic goal in such @entity1 . Regular BP monitoring is required to achieve this goal. BP monitoring at home is cheap, convenient, widely used, and guideline endorsed. However, major barriers prevent proper use. These may be overcome through use of BP telemonitoring-the secure teletransmission of BP readings to a health portal, where BP data are summarized for provider and @entity1 use, with or without protocolized case management. OBJECTIVE: To examine the incremental effectiveness, safety, cost-effectiveness, usability, and acceptability of home BP telemonitoring, used with or without protocolized case management, compared with "enhanced usual care" in community-dwelling seniors with @entity6 and @entity101 . METHODS: A 300- @entity1 , 3-arm, pragmatic randomized controlled trial with blinded outcome ascertainment will be performed in seniors with @entity6 and @entity101 living independently in seniors' residences in greater Edmonton. Consenting @entity1 will be randomized to usual care, home BP telemonitoring alone, or home BP telemonitoring plus protocolized pharmacist case management. Usual care subjects will receive a home BP monitor but neither they nor their providers will have access to teletransmitted data. In both telemonitored arms, providers will receive telemonitored BP data summaries. In the case management arm, pharmacist case managers will be responsible for reviewing teletransmitted data and initiating guideline-concordant and protocolized changes in BP management. RESULTS: Outcomes will be ascertained at 6 and 12 months. Within-study-arm change scores will be calculated and compared between study arms. These include: (1) clinical outcomes: proportion of subjects with a mean 24-hour ambulatory systolic BP in the optimal range (110-129 mmHg in @entity1 65-79 years and 110-139 mmHg in those >= 80 years: primary outcome); additional ambulatory and home BP outcomes; A1c and lipid profile; medications, cognition, health care use, cardiovascular events, and mortality. (2) Safety outcomes: number of serious episodes of @entity551 , @entity1163 , falls, and electrolyte disturbances (requiring third party assistance or medical attention). (3) Humanistic outcomes: quality of life, satisfaction, and medication adherence. (4) Economic outcomes: incremental costs, incremental cost-utility, and cost per mmHg change in BP of telemonitoring    case management compared with usual care (health payor and societal perspectives). (5) Intervention usability and acceptability to @entity1 and providers. CONCLUSION: The potential benefits of telemonitoring remain largely unstudied and unproven in seniors. This trial will comprehensively assess the impact of home BP telemonitoring across a range of outcomes. Results will inform the value of implementing home-based telemonitoring within supportive living residences in Canada. TRIAL REGISTRATION: Clinicaltrials.gov NCT02721667; https://clinicaltrials.gov/ct2/show/NCT02721667 (Archived by Webcite at http://www.webcitation.org/6i8tB20Mc).

title: Telemonitoring and Protocolized Case Management for XXXX Community-Dwelling Seniors With @entity6 : Protocol of the TECHNOMED Randomized Controlled Trial.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertension-related complications']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']


abstract: AIMS: Cervical node @entity3 is the single most important prognostic factor in @entity213 . Taking a homogenous @entity1 population, applying stringent selection criteria, and standard pathological evaluation methods, this retrospective study aims to establish histological predictors of subclinical cervical node @entity3 in early (T1-T2/N0) @entity957 of the oral cavity, thereby identifying a subset of @entity1 who are at an increased risk for cervical node @entity3 . METHODS: Forty-eight previously untreated @entity1 with clinically T1 or T2, and N0, @entity957 of the oral cavity who were treated with primary excision of the @entity5 and elective neck node dissection were selected. Various histological factors including T size, gross and microscopic @entity5 depth and thickness, grade of differentiation, pattern of invasion, inflammatory response, perineural and lymphovascular invasion were studied. The statistical significance of various parameters as predictors of subclinical node @entity3 was determined using logistic regression analysis. RESULTS: Of all the parameters studied, microscopic @entity5 depth and thickness were the only significant factors (P value=0.026 and 0.046, respectively) which correlated with cervical node @entity3 , on univariate analysis. @entity5 depth emerged as a single most significant predictor on multivariate analysis. Majority of @entity1 with node @entity3 had a @entity5 depth of more than or equal to 5 mm. CONCLUSION: Depth is the most significant predictor of cervical node @entity3 in early @entity957 of the oral cavity. @entity1 with a @entity5 depth of more than or equal to 5 mm are at an increased risk of harbouring node @entity3 , hence should be taken up for elective node dissection.

title: Depth of invasion is the most significant histological predictor of subclinical cervical lymph node metastasis in early XXXX of the oral cavity.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'tumour']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous carcinomas']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous carcinomas']


abstract: OBJECTIVE: To test the hypothesis that @entity1 with chronic @entity2054 (CECS) of the anterior leg compartment have an increased anterior compartment thickness (ACT) compared with control subjects after exertion using ultrasound. DESIGN: Prospective comparison study. SETTING: Diagnostic imaging department of a tertiary care hospital. @entity1 : Four @entity1 with CECS and 9 control subjects. INTERVENTIONS: @entity1 with CECS and control subjects ran on a treadmill for up to 10 minutes. Anterior compartment thickness (both groups) and anterior compartment pressure (CECS @entity1 ) were measured before exertion and at scheduled intervals after exertion. MAIN OUTCOME MEASURES: Anterior compartment thickness, percentage change in ACT from rest, and compartment pressure. RESULTS: Anterior compartment pressures were diagnostic of CECS using the modified Pedowitz criteria in @entity1 with CECS. Mean percentage change in ACT from rest in @entity1 with CECS versus control subjects at 0.5 minutes was 21.3% versus 6.32% [95% confidence interval (CI), 6.92-35.6 and 0.094-12.5, respectively; P = 0.011]; at 2.5 minutes, it was 24.6% versus 4.22% (95% CI, 10.7-38.5 and -1.85-10.3, respectively; P = 0.003); and at 4.5 minutes, it was 24.9% versus 5.08% (95% CI, 14.3-35.5 and -0.813-11.0, respectively; P = 0.003). Mean ACT in @entity1 with CECS versus control subjects significantly increased after exertion (P = 0.003) at 0.5 minutes, 2.5 minutes, and 4.5 minutes. CONCLUSIONS: Ultrasonography reveals a significant increase in ACT in @entity1 with CECS of the anterior leg compartment. Further studies are warranted to validate these findings with the goal of developing anterior leg compartment CECS ultrasound diagnostic criteria and exploring the role of using ultrasound to diagnose CECS in other compartments.

title: The utility of ultrasound in detecting anterior compartment thickness changes in chronic XXXX : a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients', 'Patients']

entities_list: @entity2054 :: ('MESH:D003161', 'Disease') :: ['exertional compartment syndrome']

answer: @entity2054 :: (MESH:D003161,Disease) :: ['exertional compartment syndrome']


abstract: Surgery is the standard treatment of tympano-jugular @entity3506 . Radiation therapy is used only for inoperable forms. Since the @entity5 most often does not regress completely after irradiation, radiation therapy is generally considered as palliative. From 1979 to 1988, 18 @entity1 with this rare @entity5 were referred to the Necker Hospital Tumor Center for radiation therapy. These @entity1 have now been followed for 2 to 11 years. @entity5 were extensive (Fish Stage C and D) in 75% of the @entity1 and half of these @entity1 showed cranial nerve involvement in addition to the @entity154 . Three @entity1 were referred for recurrent @entity5 and 7 @entity1 had undergone surgery just prior to radiation therapy. Among the 11 @entity1 treated with the @entity5 in place, 7 had more or less complete regression of symptoms and radiologic signs, 3 had no further progression of symptoms and radiologic signs and 1 had @entity5 progression and expired as the result of the disease. No @entity1 receiving post-operative radiation therapy developed clinical or radiological evidence of recurrent @entity5 . Among the 18 @entity1 treated, 2 died of intercurrent disease. Our experience shows that a dose of 45 Gy is suffisant, leaves no trace, and does not prevent subsequent surgery. In an extensive review of the literature, @entity5 growth stopped or regressed after radiation therapy in 90% of the @entity1 reported. Therefore, if incomplete surgery or neurological operative sequelae seem unavoidable, we prefer radiation therapy to surgical management of this @entity5 .

title: [The value of radiotherapy in the treatment of tympano-jugulare XXXX . Apropos of 18 cases].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['usual otovestibular anomalies']

entities_list: @entity3506 :: ('MESH:D010236', 'Disease') :: ['chemodectomas']

answer: @entity3506 :: (MESH:D010236,Disease) :: ['chemodectoma']


abstract: BACKGROUND: Severe chronic @entity2633 ( @entity2633 ) is associated with degenerative tendon changes, extracellular matrix breakdown, and tendon cell loss. On the basis of positive outcomes from preclinical studies, this study is the first clinical trial of autologous tenocyte injection (ATI) on severe @entity924 associated with chronic @entity2633 . HYPOTHESIS: Autologous tenocyte injection is a safe and effective procedure that enables a reduction in @entity158 and improvement in function in resistant @entity2633 . STUDY DESIGN: Case series; Level of evidence, 4. METHODS: @entity1 with severe refractory @entity2633 underwent clinical evaluation and magnetic resonance imaging (MRI) before intervention. A patellar tendon needle biopsy was performed under local anesthetic, and tendon cells were expanded by in vitro culture. Tenocytes used for the injection were characterized by flow cytometry and real-time polymerase chain reaction. Autologous tenocytes were injected into the site of @entity924 identified at the origin of the extensor carpi radialis brevis tendon under ultrasound guidance on a single occasion. @entity1 underwent serial clinical evaluations and repeat MRI at 12 months after intervention. RESULTS: A total of 20 consecutive @entity1 were included in the study. Three @entity1 withdrew consent after enrollment and before ATI. No adverse event was reported at either biopsy or injection sites. Furthermore, no infection or excessive fibroblastic reaction was found in any @entity1 at the injection site. Clinical evaluation revealed an improvement in mean visual analog scale scores, for a maximum @entity158 score from 5.94 at the initial assessment to 0.76 at 12 months (P < .001). Mean quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) and grip strength scores also significantly improved over the 12-month follow-up (QuickDASH score, 45.88 [baseline] to 3.84; grip strength, 20.17 kg [baseline] to 37.38 kg; P < .001). With use of a validated MRI scoring system, the grade of @entity924 at the common extensor origin improved significantly by 12 months (P < .001). One @entity1 elected to proceed to surgery 3 months after ATI following a reinjury at work. CONCLUSION: In this study, @entity1 with chronic @entity2633 who had previously undergone an unsuccessful full course of nonoperative treatment showed significantly improved clinical function and structural repair at the origin of the common extensor tendon after ATI. This novel treatment is encouraging for the treatment of @entity924 and warrants further evaluation.

title: Autologous tenocyte injection for the treatment of severe, chronic resistant XXXX : a pilot study.

entities_list: @entity2633 :: ('MESH:D013716', 'Disease') :: ['lateral epicondylitis', 'LE']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinopathy']

answer: @entity2633 :: (MESH:D013716,Disease) :: ['lateral epicondylitis']


abstract: BACKGROUND: Since it was suggested that B cells play a role in the pathogenesis of @entity2132 , rituximab, an anti- @entity2225 monoclonal antibody targeting B cells, has been shown to be effective in @entity134 -refractory, @entity2132 . However, most of the data were from small numbers of @entity1 or retrospective analyses. We, therefore, conducted a multicenter phase II study to confirm the efficacy of this treatment strategy that targets B cells. DESIGN AND METHODS: We diagnosed and evaluated @entity2132 according to the National Institute of Health criteria for clinical trials on this condition. The treatment consisted of weekly intravenous infusions of rituximab for 4 weeks followed by monthly rituximab for 4 months. We evaluated the @entity1 ' responses and monitored their disease activity until their final visit, which was on day 365. We also assessed the @entity1 ' subsequent quality of life and serum levels of B-cell-activating factor of the @entity5 necrosis factor family. RESULTS: Among 37 @entity1 enrolled (median age, 29 years; range 8-57 years), 32 @entity1 responded to rituximab with 8 complete and 24 partial responses. Twenty-one @entity1 maintained their response for 1 year, so their @entity134 treatment was discontinued or its dose reduced (21/37, or 56.8%), and their scores representing quality of life were improved although these changes were not statistically significant. The responses were better for clinical manifestations of the skin, oral cavity and musculoskeletal system (response rate, 71.4-100%) than for other organs. However, @entity166 and @entity66 relapse accounted for the majority of treatment failure. The pre-treatment serum level of @entity8410 of the @entity5 necrosis factor family was not associated with better treatment outcome (P=0.147). CONCLUSIONS: Rituximab could improve clinical responses and quality of life of @entity1 with @entity134 -refractory @entity2132 , although such @entity1 may need active prophylaxis against @entity281 .

title: Weekly rituximab followed by monthly rituximab treatment for XXXX -refractory @entity2132 : results from a prospective, multicenter, phase II study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease']

entities_list: @entity8410 :: ('10673', 'Gene') :: ['B cell-activating factor']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['chronic graft-versus-host disease']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious complications']

answer: @entity134 :: (CHEBI:35341,Chemical) :: ['steroid']


abstract: BACKGROUND: Close to 1 in 5 @entity1 admitted to a skilled nursing facility (SNF) are readmitted to the acute hospital within 30  days, and a substantial percentage are readmitted within 2  days of the SNF admission. These rapid returns to the hospital may provide insights for improving care transitions between the acute hospital and the SNF. OBJECTIVES: To describe the characteristics of SNF to hospital transfers that occur within 48  hours and 30  days of SNF admission based on @entity614 ( @entity614 ) performed by SNF staff, and identify potential areas of focus for improving transitions between hospitals and SNFs. DESIGN: Trained staff from SNFs enrolled in a randomized, controlled clinical trial of the INTERACT (Interventions to Reduce Acute Care Transfers) quality improvement program performed retrospective @entity614 on hospital transfers during a 12-month implementation period. SETTING: SNFs from across the United States. @entity1 : 64 of 88 SNFs randomized to the intervention group submitted @entity614 . INTERVENTIONS: SNFs were implementing the INTERACT quality improvement program. MEASURES: Data were abstracted from the INTERACT Quality Improvement (QI) tool, a structured, retrospective RCA on hospital transfers. RESULTS: Among 4658 transfers for which data on the time between SNF admission and hospital transfer were available, 353 (8%) occurred within 48  hours of SNF admission, 524 (11%) 3 to 6  days after SNF admission, 1450 (31%) 7 to 29  days after SNF admission, and 2331 (50%) occurred 30  days or longer after admission. Comparisons between transfers that occurred within 48  hours and within 30  days of SNF admission to transfers that occurred 30  days or longer after SNF admission revealed several statistically significant differences between @entity1 risk factors for transfer, symptoms and signs precipitating the transfers, and other characteristics of the transfers. Hospitalization in the last 30  days and year was significantly more common among those with rapid returns to the hospital. @entity1353 was significantly more common among those transferred within 48  hours or 30  days, and falls, functional decline, suspected @entity1729 , and new @entity322 less common. SNF staff rated a higher proportion of transfers within 30  days versus 30  days or longer as potentially preventable (25.1% vs 21.5%, P  =  .005). Case descriptions derived from the QI tools of transfers back to the hospital within 48  hours of SNF admission illustrate several factors underlying these rapid returns to the hospital. CONCLUSION: @entity614 on transfers back to the hospital shortly after SNF admission provide insights into strategies that both hospitals and SNFs can consider in collaborative efforts to reduce potentially avoidable hospital readmissions.

title: Hospital Transfers of Skilled Nursing Facility (SNF) XXXX Within 48 Hours and 30  Days After SNF Admission.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['Shortness of breath']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infection']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['RCAs', 'root cause analyses']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Recent studies have shown that @entity1569 is associated with risk factors for @entity65 ( @entity65 ). OBJECTIVES: To evaluate the epidemiological profile of @entity1 with @entity1569 , focusing on the risk factors for @entity65 and @entity32 . MATERIALS _ METHODS: @entity1 with a diagnosis of @entity1569 who were attended at the dermatology outpatient clinic of a university hospital were evaluated. RESULTS: 229 adult @entity1 of mean age 50 years, among whom 52% were male, were evaluated. Twenty @entity1 (8.7%) were concomitantly affected by @entity5144 . From analysis on laboratory tests from 177 @entity1 , we saw that 111 (62.7%) were dyslipidemic and that among these, only 9 (8%) were undergoing treatment. 35.6% presented abnormal glycemia tests, but 22% were not having any treatment for the glycemic alteration observed. We analyzed possible associations of the severity of @entity1569 and length of time with the disease with @entity4977 , @entity74 and @entity262 arterial @entity101 , but did not find any significant associations. CONCLUSION: The findings observed in this study corroborate previous findings in similar studies, thus demonstrating that the prevalence of risk factors for @entity65 among @entity1 with @entity1569 is greater than in the general population, but that a large proportion of such @entity1 do not undergo treatment for this. We did not find any possible association between the inflammatory process and the genesis of risk factors for @entity65 , although the magnitude of this evidence is not strong. These findings serve to alert dermatologists to remain attentive to these factors, among @entity1 with @entity1569 .

title: Risk factors for @entity65 in XXXX : relation to @entity32 assessed by the severity and duration of illness.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic arthritis']

entities_list: @entity4977 :: ('MESH:D052439', 'Disease') :: ['lipid disorders']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['glycemic disorders']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVDs', 'cardiovascular diseases']

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: OBJECTIVE: To explore the mechanisms of scalp acupuncture in treating @entity2806 in @entity35 . METHODS: Sixty SD @entity35 with @entity2500 ( @entity2500 ) were randomly divided into untreated group and scalp acupuncture group. The scalp acupuncture was performed by inserting needles from Baihui (GV20) to Qubin ( @entity26009 ), and the scalp was stabbed through 0.5 to 0.8 cun with a 30 degree angle. After a Han's Electro-Acupuncture Apparatus was connected, we selected "disperse-dense" wave and alternated frequency of 2 Hz and 100 Hz at an intensity level of 2 mA, 30 min once daily. Another 10 SD @entity35 without @entity432 were taken as sham-operated control. Neurological severity score (NSS), @entity1710 and @entity1711 (HE) staining, polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) were applied to observing the changes of neurofunctional defect, the inflammatory infiltration in cerebral tissue and the contents of @entity4645 ( @entity4645 ), nuclear factor-kappa B (NF-kappaB) and @entity1810 ( @entity1810 ) in brain tissues after 24-, 48- and 72-hour reperfusion. RESULTS: There were significant differences in NSS between the scalp acupuncture group and the untreated group (P<0.05, P<0.01) after 24-, 48- and 72-hour reperfusion, especially after 72-hour reperfusion. HE staining results of @entity63 cerebral tissues showed an apparent reduction of inflamed lesions in the scalp acupuncture group as compared with the untreated group, especially after 72-hour reperfusion. The contents of @entity4645 and NF-kappaB after reperfusion in the scalp acupuncture group were significantly lower than those in the untreated group in 24, 48 and 72 h (P<0.01, P<0.05), and the contents of @entity1810 in scalp acupuncture group were significantly higher than those in the untreated group after 24-, 48- and 72-hour reperfusion (P<0.01). CONCLUSION: Scalp acupuncture can attenuate @entity2806 -reperfusion injury, improve neurofunctional rehabilitation and suppress leukocyte infiltration in @entity35 by decreasing the contents of @entity4645 and NF-kappaB and enhancing @entity1810 expression in brain tissues.

title: [Effects of scalp acupuncture on acute XXXX -reperfusion injury in @entity35 ].

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['MCAO', 'middle cerebral artery occlusion']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusion']

entities_list: @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['transforming growth factor-beta1', 'TGF-beta1']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']


abstract: OBJECTIVE: To investigate the relationship between @entity7 ( @entity7 ) expression and microvessel injury of renal interstitium in @entity1 with Henoch-Sch  nlein @entity7860 ( @entity5417 ). METHODS: Thirty-two @entity1 with @entity5417 and who had not received glucocorticoid or immunodepressants treatment before hospitalization were enrolled. Five @entity1 undergoing nephrectomy due to renal @entity130 were used as the control group. Renal samples were stained by @entity1710 and @entity1711 and renal pathological changes were evaluated semi-quantitatively. @entity2280 and @entity7 expression was detected by immunohistochemistry. @entity2280 was used as the marker for endothelial cells of renal microvessels. The microvessel density (MVD) was calculated by @entity2280 immunostaining. RESULTS: Compared with the control and the renal pathological grade II @entity5417 groups, MVD in the grade III and above @entity5417 groups decreased significantly, with an obvious reduction in MVD with the increased renal pathological grade (p<0.05). The renal microvessel score in the grades IIIa, IIIb, IV, and V @entity5417 groups decreased obviously compared with that in the control group. The renal microvessel score decreased with the increased renal pathological grade (p<0.05). @entity7 expression in the grade II @entity5417 group was higher (p<0.05), while that in the grades IV and V @entity5417 group was lower than that in the control group (p<0.05). @entity7 expression in the @entity5417 group showed a significant reduction with the increased renal pathological grade (p<0.05). There was a positive correlation between @entity7 expression and MVD in renal tissue in the @entity5417 group (r=0.935, p<0.01). CONCLUSIONS: The decreased expression of @entity7 may be responsible for the renal pathological damage and microvessel injury in @entity5417 .

title: [Expression of XXXX is related to microvessel injury of renal interstitium in @entity1 with Henoch Sch  nlein @entity7860 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity7860 :: ('MESH:D019867', 'Disease') :: ['purpura nephritis']

answer: @entity7 :: (7422,Gene) :: ['vascular endothelial growth factor']


abstract: Atrial natriuretic peptides cause natriuresis, kaliuresis, diuresis, and @entity551 . They relax vascular smooth muscle in vitro, and they dilate renal vessels in vivo. Hence, we tested the hypothesis that they produce @entity551 by lowering total peripheral resistance. The studies were performed in conscious chronically instrumented @entity742 standing quietly in their cages. Atriopeptin II (AP II) was infused into the right atrium for 30 min at 0.1 nmol X kg-1 X min-1. Atriopeptin II lowers arterial pressure (9%, P less than 0.05) by lowering cardiac output (18%, P less than 0.05), @entity64 volume (28%, P less than 0.05), and right atrial pressure (2.3 mmHg, P less than 0.05). Heart rate and total peripheral resistance increase (16 and 13%, respectively, P less than 0.05). Partial ganglionic blockade with @entity13673 camsylate during AP II infusion prevents the increases in heart rate and total peripheral resistance. The changes in right atrial pressure, @entity64 volume, and cardiac output persist, and arterial pressure falls further (27%, P less than 0.05). These hemodynamic data are consistent with direct AP II-induced relaxation of venous smooth muscle with reduction of @entity1700 , right atrial pressure, @entity64 volume, cardiac output, and arterial pressure, followed by reflex activation of the sympathetic nervous system to increase heart rate and total peripheral resistance. Because partial ganglionic blockade alone and AP II alone cause similar reductions in right atrial pressure (2.1 and 2.3 mmHg, respectively) but AP II causes a greater fall in @entity64 volume (28 vs. 13%), it is possible that AP II also causes coronary vasoconstriction.

title: Atriopeptin II lowers cardiac output in conscious XXXX .

entities_list: @entity1700 :: ('MESH:D012587', 'Disease') :: ['venous return']

entities_list: @entity13673 :: ('MESH:D014294', 'Chemical') :: ['trimethaphan']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

answer: @entity742 :: (9940,Species) :: ['sheep']


abstract: UNASSIGNED: @entity50 ( @entity50 ) is an uncommon form of @entity64 with a variable presentation, ranging from headaches, to @entity772 and @entity204 . Although the American @entity64 Association has developed guidelines for the treatment of @entity50 , data are sparse on the outcome after treatment with anticoagulation, thrombolysis, and thrombectomy. In this retrospective review, we describe the 5-year UC Davis experience with spontaneous @entity50 . Forty-one @entity1 (mean age 37.5  23.1, range 0-96   years; 29 female) were identified with @entity50 . The majority of cases involved the transverse sinus (75.6%), sigmoid sinus (58.5%), and superior sagittal sinus (29.3%). The most common form of treatment was anticoagulation or antiplatelet therapy (n=35), while six @entity1 were managed by observation alone. The overall 1-year modified Rankin score (mRS) was 1.4  1.5. Male @entity1 and @entity1 with a poor admission mRS had a worse outcome. Outcome was unaffected by hypercoagulable state, number of dural sinuses involved, the presence of @entity932 , or @entity410 . Two @entity1 who underwent anticoagulation therapy also required endovascular thrombectomy; both @entity1 had a 1-year mRS of  <=2. Two @entity1 underwent direct open surgical canalization of the superior sagittal sinus with varying outcomes ( @entity5329 vs mRS 6). In our series, the majority (92.9%) of @entity1 with spontaneous dural sinus @entity715 had a favorable clinical outcome as defined by a mRS  <=2. Further prospective studies are needed to study the impact of anticoagulation on the clinical course of the disease.

title: Management and outcome of spontaneous XXXX in a 5-year consecutive single-institution cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['Cerebral venous sinus thrombosis', 'CVST']

answer: @entity50 :: (MESH:D012851,Disease) :: ['cerebral venous sinus thrombosis']


abstract: OBJECTIVE: To determine if preoperative @entity4988 is associated with postoperative wound complications among @entity1 with @entity5 . METHODS: The National Surgical Quality Improvement Program database was queried for cases of @entity5 undergoing vulvectomy with or without lymphadenectomy (LND) from 2008 to 2013. Primary outcome was major wound complication. Secondary outcome was minor wound complication. @entity4988 was defined as albumin<3.5g/dL. Descriptive statistics and multivariable logistic regression were used for analysis. RESULTS: Of 777 @entity5 @entity1 , 514 (66.2%) had vulvar surgery alone and 263 (30.3%) had a LND. Median age was 66 (range 20-90) and median BMI was 28.9kg/m(2) (range 14.3-65.5). The incidence of wound complication was 10.4% (81/777) with 48 minor and 39 major complications. There was no difference in major wound complications when a LND was performed (p=1.0). Preoperative albumin was recorded in 429 @entity1 (55.2%). @entity1 with @entity4988 were more likely to have a major wound complication (OR 2.9 95% CI 1.1-7.3, p=0.02), even after adjusting for BMI, age, preoperative hematocrit, and @entity6 (aOR 2.7 95% CI 1.1-7.1, p=0.04). In bivariable analysis, age, @entity6 , and BMI were not associated with wound complication. @entity1 with a wound @entity281 had 10 times the odds of being readmitted within 30days (OR 9.5, 95% CI 4.9-18.4, p<0.01). CONCLUSIONS: Low preoperative albumin is associated with @entity260 in @entity1 undergoing surgery for @entity5 . When obtaining informed consent, @entity1 with low albumin should be counseled regarding higher risks of @entity260 .

title: Association between @entity4988 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia', 'Hypoalbuminemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['vulvar cancer']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative wound complication', 'major postoperative wound complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity5 :: (MESH:D009369,Disease) :: ['surgical site infection in vulvar cancers']


abstract: Sixteen @entity1 with refractory @entity294 and three malnourished @entity1 who had frequent episodes of @entity697 but little @entity294 at the time of hospital admission, were studied by peroral upper small intestinal biopsy. Six @entity1 were adequately nourished; five @entity1 weighed 62 to 79% of expected weight and eight weighed less than 60% of expected weight. Two of the malnourished @entity1 had @entity7014 . Pathogenic bacteria were found in only one case. Varying degrees of @entity194 with reduction of mean villous height were seen in 18 cases. The concentration of mononuclear inflammatory cells and plasma cells was about half that seen in well-nourished @entity1 with severe @entity281 . The concentration of mononuclear cells in the lamina propria was about twice that seen in normal adults. The proportions of IgA-producing cells and cells that stained for secretory component were significantly reduced, as compared with normal adult control values. This reduction was most striking in @entity1 with @entity3147 complicated by @entity7014 . Enzyme histochemical studies were performed for @entity368 @entity2965 , alkaline phosphatase and acid phosphatase. There was a tendency for considerably reduced acid phosphatase activity in all clinical groups (kwashiorkor, marasmic kwashiorkor and marasmus) of growth-retarded @entity1 .

title: Infantile jejunal mucosa in @entity281 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infants']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute gastroenteritis']

entities_list: @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['nongastrointestinal infections']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['mucosal atrophy']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity7014 :: ('MESH:D005873', 'Disease') :: ['giardiasis']

answer: @entity3147 :: (MESH:D044342,Disease) :: ['malnutrition']