abstract: Recent studies have demonstrated that alleles at single nucleotide polymorphisms (SNPs) @entity18568 and @entity18567 within genes @entity8167 and @entity8164 , respectively, had a significant impact on the susceptibility to @entity8 ( @entity8 ). Analysis of the two genomic loci could identify alleles for individuals at risk for @entity8 . Conventional methods for genotyping are labor intensive, expensive or time consuming. High resolution melting (HRM) is a new technique for genotyping and has the advantages of simplicity, speed, high sensitivity and low cost. Here, we describe genotyping of SNPs @entity18568 and @entity18567 using HRM. In this study, we identified polymorphisms of @entity18568 and @entity18567 in 480 healthy unrelated Chinese volunteers of two ethnic groups from three different geographical areas in China. The two genomic loci were genotyped by HRM using a saturating fluorescent dye SYTO   9 on 7900 HT and RG 6000 instruments, and were further confirmed by direct DNA sequencing. Three different SNP genotypes were sufficiently distinguished by HRM with mean sensitivity of 98.8% and mean error rate of 1.9%. In addition, the allele frequencies varied greatly based on ethnic or geographic origins. In conclusion, HRM is a rapid, cost efficient, sensitive, suitable technique for genotyping, and simple enough to be readily implemented in a diagnostic laboratory. We believe this will be a valuable technique for determining the genotype of @entity18568 and @entity18567 and for assessing individual susceptibility to @entity8 .

title: Development of a high resolution melting method for genotyping of risk @entity8167 and XXXX alleles and ethnic distribution of these risk alleles.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['IMN', 'idiopathic membranous nephropathy']

answer: @entity8164 :: (22925,Gene) :: ['PLA2R1']


abstract: PURPOSES: International guidelines recommend antibiotics within 1 hour of @entity326 recognition; however, a recently proposed performance measure is focused on measuring antibiotic administration within 3 hours of @entity341 ( @entity341 ) arrival. Our objective was to describe the time course of @entity326 and subsequent implications for performance measurement. BASIC PROCEDURES: Cross-sectional study of consecutive @entity341 @entity1 ultimately diagnosed with @entity326 . All @entity1 were evaluated at an urban, academic @entity341 in 2006 to 2008. Primary outcomes included time to definition of @entity326 and performance on 2 measures: antibiotics within 3 hours of @entity341 arrival vs antibiotics within 1 hour of @entity326 . MAIN FINDINGS: Of 267 @entity1 with @entity326 , the median time to definition was 88 minutes (interquartile range, 37-156), and 217 @entity1 (81.9%) met the definition within 3 hours of arrival. Of 221 (83.4%) of @entity1 who received antibiotics within 3 hours of arrival, 38 (17.2%) did not receive antibiotics within 1 hour of definition. Of 207 @entity1 who received antibiotics within 1 hour of definition, 11.6% (n = 24) did not receive antibiotics within 3 hours of arrival. The arrival measure did not accurately classify performance in 23.4% of @entity1 . PRINCIPAL CONCLUSIONS: Nearly 1 of 5 @entity1 cannot be captured for performance measurement within 3 hours of @entity341 arrival due to the variable progression of @entity326 . Use of this measure would misclassify performance in 23% of patients. Measuring antibiotic administration based on the clinical course of @entity326 rather than from @entity341 arrival would be more appropriate.

title: Time to antibiotics for XXXX : evaluating a proposed performance measure.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock definition', 'septic shock']

answer: @entity326 :: (MESH:D012772,Disease) :: ['septic shock']


abstract: BACKGROUND: The incidence of @entity5 in the proximal third of the stomach is increasing. @entity4094 ( @entity4094 ) seems an attractive option for the treatment of @entity5 but has not gained wide acceptance because of technical difficulties, including the prevention of severe reflux. In this study, we describe our technique for @entity7173 ( @entity7173 ) and evaluate its safety and feasibility. METHODS: In this retrospective analysis, we reviewed the data of @entity1 with proximal @entity356 who underwent @entity7173 (n = 22) or the same procedure with open surgery (OPG-IP; n = 68) between January 2008 and September 2011. Short-term surgical variables and outcomes were compared between the groups. The reconstruction method was the same in both groups, with creation of a 15 cm, single-loop, jejunal interposition for @entity254 . RESULTS: There were no differences in @entity1 or @entity5 characteristics between the groups. Operation time was longer in the LGP-IP group (233 vs. 201 min, p = 0.0002) and estimated @entity190 was significantly less (20 vs. 242 g, p < 0.0001). The average number of harvested lymph nodes did not differ between the two groups (17 vs. 20). There also were no differences in the incidence of leakage at the esophagojejunostomy @entity254 (9.1 vs. 7.4%) or other @entity260 (27 vs. 32%). The number of times additional postoperative analgesia was required was significantly less in the @entity7173 group compared with the OPG-IP group (2 vs. 4, p < 0.0001). CONCLUSIONS: @entity7173 has equivalent safety and curability compared with OPG-IP. Our results imply that @entity7173 may lead to faster recovery, better cosmesis, and improved quality of life in the short-term compared with OPG-IP. Because of the limitations of retrospective analysis, a further study should be conducted to obtain definitive conclusions.

title: XXXX with jejunal interposition for @entity356 in the proximal third of the stomach: a retrospective comparison with open surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['Laparoscopic proximal gastrectomy', 'LPG']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'early-stage proximal gastric cancer', 'cancer']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity7173 :: ('MESH:D007184', 'Disease') :: ['LPG with jejunal interposition', 'LPG-IP']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity4094 :: (MESH:D009468,Disease) :: ['Laparoscopic proximal gastrectomy']


abstract: BACKGROUND: Recent studies have suggested that mature T cells can change their specificity through reexpression of recombination-activating genes (RAG) and RAG-mediated V(D)J recombination. This process is named receptor revision and has been observed in mature peripheral T cells from @entity19 and @entity1 donors. However, whether thebreceptor revision in mature T cells is a random or orientated process remains poorly understood. Here we used the Jurkathuman T cell line, which represents a mature stage of T cell development, as a model to investigate the regulation of @entity6057 ( @entity6057 ) gene recombination. METHODS: @entity6057 Dbeta-Jbeta signal joint T cell receptor excision DNA circles (sjTRECs) were determined by nested and seminested PCR. Double-strand DNA breaks at recombination signal sequences (RSSs) in the TCRVbeta chain locus were detected by ligation-mediated-PCR. Further analysis of the complementarity-determining region 3 (CDR3) size of the TCRVbeta chain was examined by the @entity6057 GeneScan technique. RESULTS: @entity12656 , @entity37671 , and three crucial components of the nonhomologous DNA end-joining (NHEJ) pathway were readily detected in Jurkat. Characteristics of junctional diversity of Dbeta2-Jbeta2 signal joints and ds @entity6815 breaks associated with the Dbeta2 5' and Dbeta 2 3' sites were detected in DNA from Jurkat cells. CDR3 size and the gene sequences of the TCRVbeta chain did not change during cell proliferation. CONCLUSIONS: @entity12656 and @entity37671 and ongoing @entity6057 gene recombination are coexpressed in Jurkat cells, but the ongoing recombination process may not play a role in modification of the @entity6057 repertoire.However, the results suggest that Jurkat could be used as a model for studying the regulation of RAGs and V(D)J recombination and as a "special" model of the coexistence of @entity6057 gene rearrangements and "negative" receptor revision.

title: Expression of recombination-activating genes and T cell receptor gene recombination in the XXXX T cell leukemia cell line.

entities_list: @entity19 :: ('10090', 'Species') :: ['transgenic mice']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Administration of @entity1261 to @entity1 undergoing high-dose chemotherapy and autologous peripheral blood stem cell transplantation accelerates neutrophil recovery and decreases hospitalization time. The optimal timing for @entity1261 infusion remains unknown. In this retrospective, case-controlled, two-armed study, we reviewed our experience at Hahnemann University Hospital to determine whether initiating @entity1261 infusions on posttransplant day 0 versus day 8 affects neutrophil recovery time, posttransplant discharge date, total hospital days after high-dose chemotherapy, and autologous peripheral blood stem cell transplantation. All @entity1 hospitalized between 1994 and 1998 at Hahnemann University Hospital, Bone @entity0 or @entity1893 , who underwent high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation and received @entity1261 either on posttransplant day 0 (16 @entity1 ) or day 8 (16 @entity1 ). The day 0 and day 8 groups had no statistically significant differences in age, sex, weight, height, body surface area, disease characteristics, pretransplant harvesting or conditioning regimens, or transplant @entity2280 + cell counts. Our main outcome measure was the mean time to reach absolute neutrophil count greater than or equal to 0.5 x 10(9)/l, the number of hospital days after transplant, and the total hospital days. The mean days to neutrophil recovery (10.56 versus 9.68, p = 0.48), posttransplant hospital days (13.62 versus 12.81, p = 0.39), and total hospital days (20.25 versus 20.25, p = 1.00) were not significantly different between day 8 and day 0 groups, respectively. No significant effects on neutrophil recovery time, posttransplant hospital days, or total hospital days were observed with the initial @entity1261 infusion on day 0 versus day 8 after transplant. Delayed administration may allow substantial cost savings (US 200 x 8 approximately equal to US  1,600 per @entity1 ) without affecting clinical outcome. More studies are needed to determine whether greater delay is feasible.

title: Use of XXXX after high-dose chemotherapy and autologous peripheral blood stem cell transplantation: what is the optimal timing?

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Marrow Transplantation Unit with breast cancer']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['granulocyte colony-stimulating factor']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

answer: @entity1261 :: (1440,Gene) :: ['granulocyte colony-stimulating factor']


abstract: OBJECTIVES: As there are conflicting findings regarding the clearance-dose and @entity1 characteristics relationships for @entity1092 ( @entity2052 ), this study was conducted to investigate the relationship between @entity1 demographic characteristics, @entity2052 dosage and the drug clearance in adult Iranian @entity1 . MATERIALS AND METHODS: @entity1 (N= 47) were either on monotherapy with @entity2052 or were under co-treatment with drugs that have no effect on @entity2052 pharmacokinetic (PK) profile. All of the @entity1 received @entity2052 at therapeutic dose. Steady state trough plasma concentrations of @entity2052 were determined by Fluorescence Polarization Immunoassay (FPIA) and @entity2052 apparent clearance (CL/F) were calculated in each @entity1 . RESULTS: Mean @entity2052 dose and @entity2052 CL/F were 8.93  2.2 mg/kg/day and 0.65  0.55 l/hr respectively. No significant correlations were found between @entity2052 CL/F and @entity1 ' age, TBW and @entity2052 dose. @entity2052 CL/F values of male and female @entity1 were compared and no significant difference between these two groups was noted (P> 0.05). Significant correlation between @entity2052 dose and total trough plasma concentration was found (P= 0.001). Mean total @entity2052 plasma concentration was 54.51  23.74 mg/l. CONCLUSION: Our study showed PK of @entity2052 was not affected by age, sex, TBW and @entity2052 dose. However, for detailed results and construction of @entity2052 PK model in Iranian @entity1 , it is necessary to evaluate @entity2052 PK in a larger sample size with different @entity2052 doses, age and TBW ranges.

title: Relationship between XXXX Demographic Characteristics, @entity1092 Dosage and Clearance in Adult Iranian @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: BACKGROUND: Because of the rarity of the disease and long survival of most @entity1 , the role of adjuvant radiation therapy in @entity1 with surgically resected @entity5 is unclear, and few prospective studies are available. The objective was to evaluate the impact of postoperative radiation therapy after resection of @entity5 . METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried for all @entity1 with @entity5 who underwent surgical therapy and survived more than 30 days after diagnosis. Survival was estimated with the Kaplan-Meier method. The hazard ratio for @entity204 was determined using a Cox proportional hazard model. RESULTS: There were 476 @entity1 with @entity5 identified who underwent surgical therapy, did not receive preoperative radiotherapy, and had complete SEER records with regard to radiation treatment. Postoperative radiation therapy was given to 322 @entity1 (67.6%). @entity1 who received postoperative radiation therapy were younger and had a higher rate of debulking surgery than @entity1 who did not. @entity1 receiving postoperative radiation had a median overall survival of 127 months (95% confidence interval, 100.9 to 153.1) compared with 105 months (95% confidence interval, 76.9 to 133.1) in @entity1 treated with surgery alone (p=0.038). However, in multivariate analysis, postoperative radiation was not a significant factor affecting overall survival. Disease-specific survival was significantly improved in the adjuvant radiation group, and in multivariate analysis, improved outcomes were associated with postoperative radiation (p=0.049). CONCLUSIONS: In this large population-based study, most @entity1 with @entity5 were treated with adjuvant radiation. Postoperative radiation was associated with improved disease-specific survival, but not improved overall survival.

title: The role of adjuvant radiation therapy for resected XXXX : a population-based study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III thymoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['stage III thymoma']


abstract: In @entity1582 ( @entity1582 ), the addition of @entity2816 or @entity1749 to the standard oral @entity3601 / @entity229 combination significantly increased response rate and event-free survival. In this multicenter phase 1/2 trial, dosing, safety, and efficacy of the 4-drug combination, @entity1749 , @entity3601 , @entity229 , and @entity2816 (VMPT) was determined. @entity1749 was administered at 3 dose levels (1.0 mg/m2, 1.3 mg/m2, or 1.6 mg/m2) on days 1, 4, 15, and 22; @entity3601 was given at a dose of 6 mg/m2 on days 1 through 5 and @entity229 at 60 mg/m2 on days 1 through 5. @entity2816 was delivered at 50 mg on days 1 through 35. Each course was repeated every 35 days. The maximum tolerated dose of @entity1749 was 1.3 mg/m2. Thirty @entity1 with relapsed or refractory @entity1582 were enrolled; 20 @entity1 (67%) achieved a partial response (PR) including 13 @entity1 (43%) who achieved at least a very good PR. Among 14 @entity1 who received VMPT as second-line treatment, the PR rate was 79% and the immunofixation-negative complete response rate 36%. The 1-year progression-free survival was 61%, and the 1-year survival from study entry was 84%. Grade 3 nonhematologic adverse events included @entity281 (5 @entity1 ), fatigue (1), @entity1333 (1), and @entity1897 (2); no grade 4 @entity137 were recorded. Initial results showed that VMPT is an effective salvage therapy with a very high proportion of responses. The incidence of @entity2359 was unexpectedly low.

title: @entity1749 , @entity3601 , XXXX , and @entity2816 for relapsed @entity1582 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['Thalidomide', 'thalidomide']

entities_list: @entity3601 :: ('MESH:D008558', 'Chemical') :: ['melphalan']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity1749 :: ('MESH:C400082', 'Chemical') :: ['bortezomib', 'Bortezomib']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicities']

answer: @entity229 :: (MESH:D011241,Chemical) :: ['prednisone']


abstract: @entity189 diagnosed by large-core stereotactic biopsy (LCSBB) is often followed by definitive surgery. We report on positive (malignant) LCSBB followed by definitive surgery that failed to demonstrate @entity5 . Between January 1993 and August 1996, 206 @entity1 in our institution underwent LCSBB. @entity189 was diagnosed in 45 @entity1 (22%) of the 206 ( @entity3821 ( @entity3821 ), n = 12; @entity189 , n = 33). Twenty-nine of the 45 @entity1 subsequently underwent mastectomy, and 8 of 45 underwent lumpectomy. In 34 (92%) of these 37 @entity1 , @entity189 was demonstrated at follow-up surgery, but in 3 @entity1 (8%), mastectomy failed to reveal @entity189 . The characteristics of these three @entity1 are as follows: @entity1 1 was a 58-year-old @entity1 with a nonpalpable 6- to 8-mm nodule revealed by a screening mammogram. Three of 8 LCSBBs showed @entity3079 , but histologic examination of 50 @entity982 blocks and radiographic examination of the mastectomy sample failed to reveal @entity189 . @entity1 2 was a 64-year-old @entity1 with a nonpalpable 6- to 9-mm nodule revealed by mammogram. Six of 12 LCSBBs showed @entity420 , but histologic examination of 30 @entity982 blocks from her mastectomy sample failed to reveal @entity189 . @entity1 3 was a 72-year-old @entity1 with a history of @entity3821 . She had undergone a lumpectomy and radiotherapy, and she had suspicious @entity717 . Two of 8 LCSBBs showed comedo @entity3821 , but histologic examination of 26 @entity982 blocks and radiographic examination of the mastectomy sample failed to reveal @entity189 . Possible explanations for a mastectomy without @entity5 after @entity189 was diagnosed by LCSBB include removal of the entire lesion by LCSBB, inflammatory response obliterating remaining @entity5 , false-positive core biopsy result, @entity1 misidentification, inadequate sampling of the surgical specimen, and @entity5 . We outline a series of steps for the pathologists to follow when confronted with such a case.

title: Mastectomy without XXXX after @entity189 diagnosed by large-core stereotactic breast biopsy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients', 'patient', 'Patient']

entities_list: @entity3821 :: ('MESH:D002285', 'Disease') :: ['ductal carcinoma in situ', 'DCIS']

entities_list: @entity3079 :: ('MESH:D002288', 'Disease') :: ['colloid carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'failure to remove the tumor', 'malignancy']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinoma', 'Mammary carcinoma', 'carcinoma', 'invasive carcinoma']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['ipsilateral microcalcifications']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['tubular carcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancy']


abstract: 1. The vasodilator responses of isolated intrapulmonary arteries ( @entity9348 ) to P2-receptor agonists were investigated during adaptation to extrauterine life in the piglet. The effect of @entity120 on the normal response was determined after exposing newborn animals to @entity519 (51 kPa) for 3 days. 2. @entity6883 ( @entity855 ), @entity20483 (2-meSATP), @entity21674 ( @entity21674 ) and @entity20548 ( @entity856 ) induced a relaxation in normal newborn piglet @entity9348 pre-contracted with @entity3774 (PGF2alpha). The relaxations were not affected by removal of the endothelium. The responses to @entity855 and @entity21674 increased significantly with age. 3. The relaxation responses of @entity9348 to @entity855 , 2-meSATP and @entity21674 continued to increase normally after birth in an @entity519 environment. 4. The results of the study show that vasodilatation of porcine intrapulmonary vessels to @entity2036 increased during development from foetus to adult; that the vasodilatation to @entity3042 was mediated by P2Y-receptors on the vascular smooth muscle rather than on the endothelium; and that the P2Y-receptor mediated relaxation of @entity9348 remained normal in the pulmonary @entity101 neonate.

title: Vasodilatation of intrapulmonary arteries to P2-receptor nucleotides in normal and XXXX .

entities_list: @entity21674 :: ('MESH:C030812', 'Chemical') :: ['ADPbetaS', 'adenosine 5-O-(2-thiodiphos-phate)']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides']

entities_list: @entity6883 :: ('CHEBI:15422', 'Chemical') :: ["Adenosine 5'-triphosphate"]

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['chronic hypobaric hypoxia', 'hypoxic']

entities_list: @entity20548 :: ('CHEBI:15713', 'Chemical') :: ["uridine 5'-triphosphate"]

entities_list: @entity3774 :: ('MESH:D015237', 'Chemical') :: ['prostaglandin F2alpha']

entities_list: @entity20483 :: ('MESH:C008501', 'Chemical') :: ['2-methylthioATP']

answer: @entity120 :: (MESH:D006976,Disease) :: ['pulmonary hypertensive newborn piglets']


abstract: This preliminary analysis was designed to quantify blastocyst development of supernumerary embryos without the use of feeder cells, conditioned medium or whole serum. Embryos derived from @entity52 ( @entity52 ) that were not transferred or cryopreserved were included in this study. Ova were harvested for @entity52 after a standard ovarian stimulation with gonadotrophin-releasing hormone agonist/ @entity1 menopausal gonadotrophin (GnRHa/HMG) or follicle-stimulating hormone (FSH). Ova were collected and culture in 150 microliters droplets of P1 medium under mineral oil, in groups at 37 degrees C under 5% @entity515 , 5% O2, 90% N2 (group A) or under 5% @entity515 in air (group B) environment. Embryo transfer was performed 72 h post-harvest. Viable embryos not transferred or cryopreserved were placed in blastocyst medium and cultured for an additional 48 h in 5% @entity515 in air. Embryos that exhibited an expanded blastocoelic cavity and well-defined inner cell mass at 120 h were counted. Of 838 supernumerary embryos cultured, 448 (53.5%) reached the expanded blastocyst stage by 120 h of culture. @entity1 were given the option of cryopreservation at that time. The embryos were cryopreserved using a standard protocol with serial addition of @entity653 . Embryos reaching the blastocyst stage after more than 120 h of culture were not included. There was no difference in the proportions of blastocyst development between group A, 217/410 (53.5%) and group B, 231/428 (54%). To date, 16 @entity1 have each had up to three thawed blastocysts transferred, out of whom seven became pregnant. This report demonstrates that a simple system of sequential culture generated acceptable, viable blastocyst development (54%) with supernumerary embryos, without the use of feeder cells, conditioned medium or whole serum. Recognizing the differential metabolic requirements of early and late cleavage stage embryos has enabled the application of a @entity413 / @entity1391 -free simple culture medium (P1) for up to 72 h of culture and a complex, @entity413 -containing medium (blastocyst medium) for subsequent blastocyst development.

title: Preliminary clinical experience with XXXX blastocyst development in vitro without co-culture.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['in-vitro fertilization', 'IVF']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity12421 has been shown to be effective in the treatment of @entity15 ( @entity15 ). However, the primary mechanism by which @entity12421 mediates its therapeutic effect remains unclear. Recent studies indicate that under defined conditions, @entity12421 may downregulate DC expression of IL-12. We and others have shown that @entity12421 may also downregulate @entity1618 . In light of the recently proposed paradigm that an @entity1618 /IL-12 immunoregulatory circuit controls susceptibility to @entity792 , we examined the effect of @entity12421 on the development and behavior of the autoreactive T cell repertoire during @entity6503 ( @entity6503 ), an animal model sharing many features with @entity15 . SWXJ @entity19 were immunized with the immunodominant p139-151 determinant of myelin proteolipid protein ( @entity13743 ), and at onset of @entity6503 were treated every other day with @entity12421 . After eight weeks of treatment, we assessed autoreactivity and observed no significant @entity12421 effect on splenocyte proliferation or splenocyte production of @entity60 , @entity2047 , @entity58 , or @entity59 in response to the priming determinant used to initiate disease. However, in @entity12421 treated @entity19 , the cytokine profile in response to the priming immunogen was significantly skewed toward an increased production of @entity1618 and a concurrent decreased production of IL-12. Moreover, the in vivo modulation of the @entity1618 /IL-12 immunoregulatory circuit in response to the priming immunogen was accompanied by an aborted development of epitope spreading. Our results indicate that @entity12421 induces a reciprocal modulation of the @entity1618 /IL-12 cytokine circuit in vivo. This skewed autoreactivity establishes an inflammatory microenvironment that effectively prevents endogenous self-priming thereby inhibiting the progression of disease associated with epitope spreading.

title: Modulation of the XXXX /IL-12 cytokine circuit by interferon-beta inhibits the development of epitope spreading and disease progression in @entity19 autoimmune encephalomyelitis.

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity6503 :: ('MESH:D004681', 'Disease') :: ['EAE', 'experimental autoimmune encephalomyelitis']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']

answer: @entity1618 :: (16153(Tax:10090),Gene) :: ['IL-10']


abstract: PURPOSE: The aim of this study was to evaluate the feasibility of @entity449 repair with use of an aortouniiliac graft secured with self-expanding (Gianturco) stents. METHODS: Thirty @entity1 with a median age of 72 years (age range, 52 to 86 years) and @entity439 diameter of 6.0 cm (range, 4.0 to 9.0 cm) were treated with an aortouniiliac endovascular graft. Of these 30 procedures, 28 were carried out electively and two as emergencies for @entity439 . Of the 30 @entity1 , 21 (70%) were considered to be at high risk for open surgery. A modified Gianturco stent, Dacron graft, and Wallstent were used for these procedures. RESULTS: Endovascular repair was successfully carried out in 25 of 30 (83.3%) @entity1 . All these @entity1 were mobile and had resumed a normal diet within 48 hours of the procedure. The overall 30-day mortality rate was two in 30 (6.6%), but it was one in 28 (3.5%) for the elective cases; all @entity204 occurred in the group at high risk for surgery. Other complications encountered within 30 days of procedure included @entity583 in one @entity1 , @entity55 in two @entity1 , homonymous quadrantanopia in one @entity1 , and @entity63 in one @entity1 , giving an overall morbidity rate of four in 30 (13.3%). At a median follow-up of 4 months (range, 1 to 13 months), 27 of 30 (90%) @entity1 remain alive and well. CONCLUSION: Endovascular aortouniiliac repair of @entity1028 with Gianturco stent is feasible in both elective and emergency situations. It appears to be minimally traumatic, and the majority of @entity1 deemed to be at high risk for open surgery can safely undergo endovascular repair. However, data on more @entity1 with longer follow-up is required to determine its role in the management of @entity1028 .

title: Early results of XXXX surgery with aortouniiliac graft, contralateral iliac occlusion, and femorofemoral bypass.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['endovascular aortic aneurysm']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['colonic ischemia']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['leaking aneurysm', 'aneurysm']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

answer: @entity449 :: (MESH:D001014,Disease) :: ['endovascular aortic aneurysm']


abstract: OBJECTIVES: To evaluate the utility of thromboelastography ( @entity17792 ) and Sonoclot analyses to monitor the effects of low molecular weight heparin (LMWH) administration to healthy @entity1641 . DESIGN: Randomized crossover study. SETTING: Large animal veterinary teaching hospital. ANIMALS: Six adult mixed breed healthy mares. INTERVENTIONS: LMWH (dalteparin) was administered (50 U/kg subcutaneously) either every 12 or 24 h for 3 consecutive days. Blood samples were collected before LMWH administration and then at selected time points for analysis. Thromboelastography derived R-time (R), K-time (K), angle (ANG), and maximum amplitude (MA), and Sonoclot activated clot time (ACT), clot rate (CR), and platelet function (PF) were measured in whole blood 30 min after sample collection. Change (/\) and percentage change (%/\) from baseline of each @entity17792 and Sonoclot variable were subsequently calculated. Anti-factor Xa activity and activated partial thromboplastin time (aPTT) were assayed in harvested plasma. The association between anti-factor Xa activity and @entity17792 and Sonoclot (measured and calculated) variables was assessed by calculating correlation coefficients and multiple regression analysis. The ability of measured and calculated @entity17792 and Sonoclot variables to predict when anti-factor Xa activity fell below suggested thromboprophylactic levels was assessed using receiver operating characteristic curve analysis. MEASUREMENTS AND MAIN RESULTS: The correlation between aPTT and anti-factor Xa activity was weak (r = 0.343). Changes in @entity17792 and Sonoclot variables following LMWH administration were consistent with hypocoagulation. All measured and calculated @entity17792 variables were significantly correlated with anti-factor Xa activity. Sonoclot ACT, /\ACT, CR, /\CR, and %/\CR were also significantly correlated with anti-factor Xa activity. @entity17792 /\R and %/\R best predicted anti-factor Xa activity below the suggested thromboprophylactic level. CONCLUSIONS: Although correlations were modest, serial measurement of @entity17792 variables may be used to monitor LMWH therapy in @entity1641 ; however, further research is required in sick @entity1641 .

title: Use of viscoelastic coagulation testing to monitor low molecular weight heparin administration to healthy XXXX .

answer: @entity1641 :: (9796,Species) :: ['horses']


abstract: UNASSIGNED: This study was performed to assess the incidence of @entity166 in @entity1 undergoing autologous and allogeneic hematopoietic stem cell transplantation (HSCT). The characteristics of microbiologically documented @entity281 in 114 consecutive @entity1 undergoing HSCT (84 autologous, 30 allogeneic) were analyzed. Conditioning and the pre-engraftment period until one month was defined as the early period; the post-engraftment period until one year was defined as the late period. All patients received antibiotic prophylaxis and hematopoietic growth factors during @entity1398 . Febrile @entity1 received @entity31838 or @entity6944 plus @entity4509 or @entity5505 plus @entity4509 . A total of 117 episodes with microbiologically documented @entity281 were seen 90 of 114 @entity1 and 79% of the @entity1 experienced at least one febrile episode during their post-transplant course. Of these episodes, 69 (59%) were in the early period and 48 (41%) were in the late period. In the early period, 38.8% of causative organisms were gram-positive, 51.5% were gramnegative and 7.7% were fungi. The most common pathogens were coagulase-negative Staphylococcus (CoNS) and @entity526 in the early period. In the late period, 44.6% of causative organisms were gram-positive, 44.6% were gram-negative and 6.8% were fungi. CoNS and @entity526 were also the most commonly isolated agents in this period. Resistance to @entity3256 was detected in 47.4% of @entity16330 and 86.5% of CoNS isolates. The isolation rate was in accordance with previous reports; similar percentages of gram-positive and gram-negative isolates were found in @entity1 undergoing HSCT in both periods. However, a remarkably low rate of viridans streptococci and fungi were observed. The spectrum of pathogens detected in these cases serves as the basis for recommendations on the choice of empiric antimicrobial treatment regimens. Therefore, studies reporting local microbiological findings are necessary. We suggest that local microbiologic surveillance should be known before empiric antimicrobial therapy is started in each institution.

title: Microbiologically documented XXXX following peripheral blood stem cell transplantation: single center experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin']

entities_list: @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime']

entities_list: @entity6944 :: ('MESH:C043266', 'Chemical') :: ['cefepime']

entities_list: @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity31838 :: ('MESH:C044650', 'Chemical') :: ['imipenem-cilastatin']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious complications']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infections']


abstract: OBJECTIVE: To determine the growth-inhibitory and differentiation-inducing activity of @entity6442 ( @entity9104 ) on a @entity1 @entity11 cell line (SHG-44). @entity9104 is a type of polar solvent and a potent differentiation-inducing agent in many kinds of @entity1 @entity5 , yet its effect on @entity1 @entity11 remains unclear. METHODS: The effects of @entity9104 on cell proliferation using @entity2454 assay, cell cycle distribution (with flow cytometry), colony-forming efficiency in double-layer soft agar, tumorigenicity in athymic @entity19 , morphological changes, and glial fibrillary acidic protein expression were studied. RESULTS: At dose ranges of 0.25, 0.5, 0.75, and 1.0%, @entity9104 caused a dose-dependent proliferation inhibitory effect in monolayers and a marked dose-dependent suppression of colony-forming efficiency in double-layer soft agar with a complete loss of colony-forming ability in cells exposed to 0.75 and 1.0% @entity9104 . Accumulation of cells in G0/G1 phases was observed in @entity9104 -treated (0.5 and 1.0%) cells, also in a dose-dependent manner. SHG-44 cells exposed to @entity9104 (0.5 and 1.0%) for 15 days changed morphologically from small spindle-shaped to large polygonal and flattened stellate cells with multiple slender processes. These cells were still tumorigenic in athymic @entity19 , but the growth of xenografts was remarkably reduced, especially in the 1.0% @entity9104 -treated group. The expression of glial fibrillary acidic protein was notably increased by @entity9104 (0.5 and 1.0%). Washout experiments revealed that the effects of @entity9104 on cell proliferation and cell cycle distribution were reversible. CONCLUSION: Our results suggest that @entity9104 drove the SHG-44 cells to a more mature phenotype with inhibited growth.

title: Growth-inhibitory and differentiation-inducing activity of @entity6442 in cultured @entity1 XXXX cells.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['solid tumors']

entities_list: @entity6442 :: ('MESH:D004126', 'Chemical') :: ['dimethylformamide']

entities_list: @entity2454 :: ('MESH:C022616', 'Chemical') :: ['3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide']

answer: @entity11 :: (MESH:D005910,Disease) :: ['malignant glioma']


abstract: Most chemical carcinogens require metabolic activation to electrophilic metabolites that are capable of binding to DNA and causing gene mutation. Carcinogen metabolism is carried out by large groups of xenobiotic-metabolizing enzymes that include the phase I cytochromes P450 (P450) and phase II enzymes that include various transferases. During the past 10 years, considerable attention has been focused on the role of P450s in @entity1 @entity5 susceptibility. Polymorphisms in expression of P450s and transferases exist in @entity1 and these might render increased susceptibility or resistance to @entity5 . Thus it is important to understanding how P450s participate in the @entity105 process and to determine if they are indeed the rate limiting and critical interface between the chemical and its biological activity. Since there are marked species differences in expressions and catalytic activities of the multiple P450 forms that activate carcinogens, this validation process becomes especially difficult. To address the role of P450s in whole animal @entity105 , @entity19 were produced that lack the P450s known to catalyze carcinogen activation. @entity19 lines having disruption of genes encoding P450s @entity21570 , @entity9603 , and @entity36641 were developed by use of gene disruption in empbryonic stem cells. @entity19 lacking expression of microsomal @entity4299 hydrolase and @entity1110 : @entity3276 oxidoreductase were also made. These @entity19 exhibit no grossly abnormal phenotypes, suggesting that the xenobiotic-metabolizing enzymes have no critical roles in @entity1 development and physiological homeostasis. This explains the occurrence of polymorphisms in @entity1 and other @entity1 species. However, these null @entity19 do show differences in sensitivities to acute chemical @entity137 , thus establishing the importance of xenobiotic metabolism in activation pathways that lead to cell death. Rodent bioassays using null @entity19 and known genotoxic carcinogens should establish whether these enzymes are required for @entity105 in an intact animal model. These studies will also provide a framework for the production of @entity19 and carcinogen bioassay protocols that may be more predictive for identifying @entity1 carcinogens and validate the molecular epidemiology studies ongoing in @entity1 that seek to establish a role for polymorphisms in @entity5 risk.

title: Role of gene knockout @entity19 in understanding the mechanisms of @entity137 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'humans', 'human']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity4299 :: ('CHEBI:32955', 'Chemical') :: ['epoxide']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'Mouse', 'transgenic mice', 'Mice']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

answer: @entity105 :: (MESH:D063646,Disease) :: ['carcinogenesis']


abstract: OBJECTIVE: To find and evaluate characteristic magnetic resonance imaging (MRI) patterns for the differentiation between @entity2828 and @entity4034 . MATERIALS AND METHODS: We identified 28 consecutive @entity1 referred to our department for MRI (1.5  T) of an unclear @entity79 with clinical symptoms suggestive of @entity2828 or @entity4034 . MRI scans were re-evaluated by two experienced radiologists, typical MR imaging features were documented and a diagnostic decision between @entity2828 and @entity4034 was made. Statistical significance of the association between MRI features and the biopsy-based diagnosis was assessed using Fisher's exact test. RESULTS: The most clear-cut pattern for determining the correct diagnosis was the presence of a sharp and defined margin of the @entity79 , which was found in all @entity1 with @entity2828 , but in none of the @entity1 with @entity4034 (P   <   0.0001). Contrast enhancing soft tissue was present in all cases with @entity2828 and absent in 4 @entity1 with @entity4034 (P   =   0.0103). Cortical destruction was found in all @entity1 with @entity2828 , 4 @entity1 with @entity4034 did not present any cortical reaction (P   =   0.0103). Cystic or @entity39 areas were identified in 13 @entity1 with @entity2828 and in 1 @entity1 with @entity4034 (P   =   0.004). Interobserver reliability was very good (kappa   =   1) in @entity2828 and moderate (kappa   =   0.6) in @entity1 with @entity4034 . CONCLUSIONS: A sharp and defined margin, optimally visualized on T1-weighted images in comparison to short tau inversion recovery (STIR) images, is the most significant feature of @entity2828 in differentiating from @entity4034 .

title: XXXX versus @entity4034 : differential diagnosis with magnetic resonance imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesion']

answer: @entity2828 :: (MESH:D012512,Disease) :: ['Ewing sarcoma']


abstract: OBJECT: Giant @entity977 (> 4 cm in maximum diameter) represent a significant surgical challenge. Endoscopic endonasal surgery (EES) has recently been introduced as a treatment option for these @entity5 . The authors present the results of EES for giant @entity652 and analyze the advantages and limitations of this technique. METHODS: The authors retrospectively reviewed the medical files and imaging studies of 54 @entity1 with @entity977 who underwent EES and studied the factors affecting surgical outcome. RESULTS: Preoperative @entity227 was present in 45 @entity1 (83%) and partial or complete @entity4611 in 28 cases (52%), and 7 @entity1 (13%) presented with apoplexy. Near-total resection (> 90%) was achieved in 36 @entity1 (66.7%). Vision was improved or normalized in 36 cases (80%) and worsened in 2 cases due to @entity41 . Significant factors that limited the degree of resection were a multilobular configuration of the @entity652 (p = 0.002) and extension to the middle fossa (p = 0.045). Cavernous sinus invasion, @entity5 size, and intraventricular or posterior fossa extension did not influence the surgical outcome. Complications included apoplexy of residual @entity652 (3.7%), permanent @entity2010 (9.6%), new @entity4614 (16.7%), and @entity2841 leak (16.7%, which was reduced to 7.4% in recent years). Fourteen @entity1 underwent radiation therapy after EES for residual mass or, in a later stage, for recurrence, and 10 with functional @entity977 received medical treatment. During a mean follow-up of 37.9 months (range 1-114 months), 7 @entity1 were reoperated on for @entity5 recurrence. Three @entity1 were lost to follow-up. CONCLUSIONS: Endoscopic endonasal surgery provides effective initial management of @entity977 with favorable results compared with traditional microscopic transsphenoidal and transcranial approaches.

title: Endoscopic endonasal surgery for XXXX : advantages and limitations.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['apoplexy of residual tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity4611 :: ('MESH:D010900', 'Disease') :: ['pituitary deficiency']

entities_list: @entity4614 :: ('MESH:D007018', 'Disease') :: ['pituitary insufficiency']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas', 'giant pituitary adenomas']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']

entities_list: @entity2010 :: ('MESH:D003919', 'Disease') :: ['diabetes insipidus']

answer: @entity977 :: (MESH:D010911,Disease) :: ['giant pituitary adenomas']


abstract: AIMS AND BACKGROUND: Splenic @entity3 associated with mucinous @entity5 have been an enigma in the radiologic and oncology literature. These focal parenchymal defects from a non-metastasizing @entity5 within an organ that rarely develops metastatic foci, even with high-grade @entity5 , were studied. METHODS: Information on 9 @entity1 who underwent splenectomy with intraparenchymal splenic masses associated with @entity14 with peritoneal dissemination was collected. The CT scan, the histopathology and the clinical parameters of these @entity1 were studied. A literature review searching for prior reports of this subject was performed. RESULTS: Eight of these @entity1 had @entity5 and 1 a mucinous sigmoid @entity694 . All @entity1 had mucinous @entity189 at some time in their clinical course. These @entity5 masses had a CT image compatible with @entity3 and not compatible with @entity5 layered out of the splenic capsule. None of the @entity1 had evidence of @entity3 to other sites such as liver or lymph nodes. All @entity1 had a mucinous histopathology. Splenectomy may be associated with prolonged survival. CONCLUSIONS: From our review of the clinical information available on these 9 @entity1 , these @entity75 were thought to be an entrapment of @entity5 within splenic surface trabeculae, which expand into the splenic parenchyma resembling @entity3 . These CT findings may be more accurately referred to as splenic pseudometastases.

title: Splenic XXXX from mucinous @entity5 of the appendix and colon.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['mucinous appendiceal tumors', 'splenic tumor', 'mucinous tumor', 'cancer', 'malignancy', 'intraabdominal tumors']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['splenic lesions']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['appendiceal or colorectal mucinous tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'metastatic disease']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: STUDY DESIGN: Analysis of the clinical results of 20 @entity1 with @entity1514 treated by anterior procedure with Kaneda anterior spinal system. OBJECTIVES: To evaluate the efficacy of the anterior surgical correction procedure with a new anterior instrumentation in @entity1514 . SUMMARY OF BACKGROUND DATA: Posterior correction and fusion with posterior instrumentation has been a main component of the surgical management of @entity1514 . However, to the best of the authors' knowledge, no clinical results of anterior instrumentation surgery for @entity1514 have been published in the English literature. METHODS: Anterior correction and fusion using Kaneda anterior spinal system was performed in 20 @entity1 with @entity1514 (3 @entity1 with King @entity1605 , 13 with Type III, and 4 with Type IV). The average follow-up was 3 years, with a range of 2 years, 3 months to 4 years, 1 month. There were 1B @entity1 with @entity2112 (13 adolescents and 5 adults) and 2 @entity1 with a single thoracic curve caused by other etiologies. All @entity1 had correction of @entity1635 by fusion within the major thoracic curve. Radiographic evaluations were performed to analyze frontal, sagittal, and @entity717 of the spine. RESULTS: The average correction rate of @entity1635 was 71%. Above the instrumented levels, the correction rate was 75%. @entity1513 of the instrumented levels of 7 degrees was corrected to 14 degrees of @entity1513 . The trunk shift was improved from 17 mm before surgery to 9 mm at final follow-up evaluation. The average improvement of the tilt-angle in the lower and vertebra of fusion was 81%, and was 83% in the stable vertebra. Apical @entity717 showed correction rate of 15% in @entity1 without performing resection of the rib head joints and rod rotation maneuver (n = 6). However, the correction rate was improved to 58% after introduction of the technique discussed (n = 14). The angle of tangential @entity85 (rib hump) showed a correction rate of 50%. There was 1.2 degrees of frontal plane and 1.0 degree of sagittal plane correction loss within the instrumented area at final follow-up evaluation. At final follow-up, nonunion at the uppermost segment of the fusion range developed in one @entity1 , and decompensation in the lumbar spine was observed in one @entity1 with @entity1605 . CONCLUSIONS: Anterior correction with Kaneda anterior spinal system provides excellent correction of the frontal curvature and sagittal alignment by fusing within the range of the major curve, without a significant loss of correction and implant failure. @entity2003 of the @entity1514 is effectively corrected by resection of the rib head joints and rod rotation maneuver. However, too much correction of the thoracic curve should be avoided, to prevent decompensation of the lumbar curve, especially in @entity1605 .

title: Anterior correction of XXXX with Kaneda anterior spinal system. A preliminary report.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['Type II curves', 'Type II curve']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['Rigid rotational deformity']

entities_list: @entity1513 :: ('MESH:D007738', 'Disease') :: ['Preoperative kyphosis', 'kyphosis']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic scoliosis']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['rotational deformities', 'vertebral rotation']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['rib deformity']

answer: @entity1514 :: (MESH:D013896,Disease) :: ['thoracic scoliosis']


abstract: The extrinsic innervation of the abdominal organs in neonatal and adult female @entity35 is described. Mainly an in toto acetylcholinesterase method was used; moreover, @entity406 -induced fluorescence and acetylcholinesterase were demonstrated in sections. The major splanchnic nerve has its origin in the ninth and tenth thoracic sympathetic trunc ganglia. In the major splanchnic nerve a suprarenal ganglion is present. Sometimes the minor splanchnic nerve, arising from the tenth @entity4494 , joins the distal part of the suprarenal ganglion. The left and right major @entity129 join the left and right celiac ganglia in the plexus. The left celiac ganglion is always bigger than the right one. The celiac plexus and the celiac inferior mesenteric plexus are joined by the intermesenteric plexus. @entity2333 , originating in the caudal part of the thoracic sympathetic truncs, also join the abdominal prevertebral plexuses. The lumbar @entity129 , not symmetrical in their origin, join the prevertebral plexuses and give off branches to the abdominal organs. The suprarenal glands receive bundles of nerve fibers, sometimes ganglionated, from the suprarenal ganglion. The kidneys are innervated from the celiac plexus, the @entity129 and the intermesenteric plexus. The ovarian nerves are derived from the celiac plexus, the intermesenteric plexus and the @entity129 . Bundles of nerve fibers run from the suprarenal ganglion in the celiac plexus in the direction of the suspensory ligament of the ovary. In many respects this description is at variance with existing literature on the autonomic innervation in the @entity35 . These differences with the standard literature are relevant to those workers engaged in experiments on the sympathetic innervation of abdominal viscera.

title: The extrinsic innervation of the abdominal organs in the female XXXX .

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['splanchnic nerves', 'upper lumbar splanchnic nerves']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formaldehyde']

entities_list: @entity4494 :: ('MESH:D045888', 'Disease') :: ['thoracic ganglion']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['Para-aortic nerves']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: This study explores sexual function and the influence of different treatment modalities on sexual function and body image among long-term survivors of @entity5 (TCSs). METHODS: A long-term follow-up assessment of all @entity5 @entity1 treated at Aarhus University Hospital, Denmark, from 1990 to 2000 was conducted. A total of 401 survivors (mean age: 46.6years; response rate: 66%) completed questionnaires concerning sexuality and changes in body image. Based on the treatment received, @entity1 were categorised into one of four groups: surveillance, radiotherapy, chemotherapy, or chemotherapy supplemented with retroperitoneal lymph node dissection (RPLND). RESULTS: @entity250 were reported: 24% reduced sexual interest, 43% reduced sexual activity, 14% reduced sexual enjoyment, 18% @entity323 , 7% ejaculatory problems and 3% increased sexual discomfort. Seventeen percent of the long-term TCSs reported changes in body image, and this was significantly associated with all six parameters of @entity250 . When comparing treatments, only the RPLND procedure was associated with @entity250 in the form of @entity409 . CONCLUSION: Apart from RPLND, which was associated with @entity409 , treatment strategies for @entity5 appeared not to influence @entity250 . The level of @entity323 seen in this sample of TCSs seemed to be higher than the level observed in the general male population and high levels of @entity323 were associated with negative changes in body image. The results suggest that changes in body image are of importance when explaining the variation in @entity250 , but further prospective studies are needed to clarify this issue.

title: Sexuality and body image in long-term survivors of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['testicular cancer']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['ejaculatory dysfunction']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction', 'sexual dysfunctions', 'Sexual dysfunctions']

answer: @entity5 :: (MESH:D009369,Disease) :: ['testicular cancer']


abstract: BACKGROUND: Many @entity5 survivors are still not active enough to reap the benefits of physical activity. This study aimed to explore the correlation between perceived barriers and participation in exercise among multi- ethnic Malaysian @entity1 with @entity0 . METHODS: A cross-sectional study using a pre-post questionnaire and a media-clip as a @entity5 control strategy was conducted on a random sample of @entity1 with @entity0 . The tools were structured questionnaires to collect socio-medical demographic and physical activity data (e.g. barriers, exercise self-efficacy). RESULTS: A statistically significant relationship between level of physical activity before and after diagnosis of @entity0 (n=51,   2=70.14, p<0.01) was found, whereby @entity1 who rated more hours of physical activity before diagnosis were likely to persevere with exercise after diagnosis, r(49)=0.73, p<01. Some 76.5% of @entity1 engaged in low level activity and 23.5% of the @entity1 engaged in moderate level of physical activity. CONCLUSIONS: Despite the many benefits of physical activity, the majority of survivors in this study were not found to be physically active, and did not even consciously think of exercise participation. Lack of time is the main barrier amongst those survivors who are predominantly 40-50 year old housewives juggling with household chores, childcare and/or job commitments. Public health messages stressing that short bouts of exercise or some exercise are better than no exercise needs to be emphasised consistently.

title: Barriers to exercise: perspectives from multiethnic XXXX survivors in Malaysia.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'participants']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: Five different @entity1 @entity23521 genes, the @entity27821 , @entity5824 , @entity44214 , @entity44215 and @entity23521 genes, have been cloned to date. We transfected HeLa cells and Namalwa cells with each of the five different genes, and established a series of stable cloned transformant cells. Thin-layer chromatography immunostaining analysis revealed that all five enzymes were able to synthesize sialyl @entity5824 (sLe(x)) epitopes on glycolipids in HeLa cells, but each enzyme showed a different preference as to the @entity1735 chain length on glycolipids as acceptor substrates. @entity27821 and @entity44214 showed very similar patterns of sLe(x) positive bands, which indicated that the enzymes have similar acceptor substrate specificities. @entity44215 exhibited a little different pattern from those of the former two enzymes. @entity5824 and @entity23521 showed similarity in the positive bands, however, their patterns were quite different from those of the former three enzymes. Four enzymes except for @entity23521 were able to synthesize the @entity5824 (Le(x)) epitope on glycolipids in HeLa cells. @entity44214 alone showed a little different pattern of Le(x) positive bands from those of the other three enzymes. Flow cytometric analysis of HeLa cells and Namalwa cells again demonstrated the similar specificities of @entity27821 and @entity44214 . They exhibited similar stronger staining with FH6 (anti-sLe(x)) antibodies than that with the other enzymes. A phylogenetic tree of the five enzymes constructed using the neighbor-joining method showed good agreement with the similarities in the enzyme substrate specificity.

title: Distinct substrate specificities of five XXXX alpha-1,3-fucosyltransferases for in vivo synthesis of the sialyl @entity5824 and @entity5824 epitopes.

entities_list: @entity23521 :: ('2529', 'Gene') :: ['alpha-1,3-fucosyltransferase', 'Fuc-TVII']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND AND PURPOSE: The trend towards a shorter stay in rehabilitation clinic has implications for future language therapy. @entity34 ( @entity34 ) is administered 3 h per day for a total of 30 h of treatment. It was evaluated for @entity1 with chronic @entity2026 . In the present study we investigated the efficacy of a modified @entity34 schedule and included @entity1 with sub-acute @entity64 . We conducted a randomised, single-blind, parallel-group study. The results were compared to those of @entity1 who received identically intensive treatment focusing on conventional @entity2026 therapy. METHODS: Fifty @entity1 were treated with our modified version of @entity34 and 50 received a standard @entity2026 therapy at the same intensity and duration. Inclusion criteria were clinical diagnosis of first-ever @entity64 , @entity2026 in the sub-acute stage and German speakers. Language function was evaluated using the Aachen Aphasia Test and the Communicative Activity Log directly before therapy onset, after the training period and at 8-week and 1-year follow-ups. RESULTS: @entity1 of both groups improved significantly in all sub-tests of the Aachen Aphasia Test Battery. The improvements remained stable over a 1-year follow-up period. @entity1 and relatives of both groups rated daily communication as significantly improved after therapy. CONCLUSIONS: Both @entity34 and conventional therapy performed with equal intensity are efficacious methods for @entity1 with sub-acute @entity2026 . The modified @entity34 schedule is practical in an everyday therapeutic setting. Our results indicate that a short-term intensive therapy schedule in the early @entity2026 stage leads to substantial improvements in language functions.

title: XXXX following sub-acute @entity64 : a single-blind, randomised clinical trial of a modified therapy schedule.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['CIAT', 'Constraint-induced aphasia therapy']

answer: @entity34 :: (MESH:D016609,Disease) :: ['Constraint-induced aphasia therapy']


abstract: INTRODUCTION: The pathophysiology of @entity295 consists of two phases. A first phase characterized by a substantial increase of pro-inflammatory mediators including cytokines and systemic inflammatory markers, and a second phase (immunoparalysis, @entity20960 ) associated with the rise of anti-inflammatory mediators. In this study we prospectively analyzed 52 consecutive @entity1 with diagnosis of @entity1850 ( @entity1850 ) at hospital admission to evaluate prognostic and early diagnostic performance of @entity688 ( @entity688 ), soluble @entity2902 (sCD25) and @entity379 ( @entity379 ) and to confirm the prognostic accuracy of the sequential organ failure assessment (SOFA) score. METHODS: @entity1 were divided in two groups (group 1, n=28 @entity1 with bacteremic @entity1850 and group 2, n=24 @entity1 with non-bacteremic @entity1850 ) and then stratified into survivors (n=39) and nonsurvivors (n=13). Serum markers were evaluated on the day of hospital admission (D-1) and on the 7th day of hospital stay (D-7). Concentration of sCD25 was evaluated by a sandwich ELISA kit. Levels of @entity688 and @entity379 were quantified by a cytokine biochip array by the evidence investigator analyzer. Differences between groups were established by the Mann-Whitney test. Accuracy, sensitivity and specificity of diagnostic markers were evaluated by the receiver-operating characteristic curve analysis. Multivariate analysis was carried out to evaluate whether studied biomarkers are independent predictors of poor outcome in prognosis, and of bacteremic @entity1850 in diagnosis. RESULTS: @entity688 , sCD25 and SOFA scores of survivors and nonsurvivors were significantly different both at D-1 (P=0.0014; P=0.014 and P=0.0311 respectively) and at D-7 (P=0.0002, P=0.014 and P=0.0012 respectively). Between the above groups @entity379 level was significantly different only at D-7 (P=0.0013). Moreover @entity688 and sCD25 were significantly higher in bacteremic versus non-bacteremic @entity1850 @entity1 at D-1 and at D-7 (P<0.05). @entity379 values showed a significant decrease (P<0.05) in @entity1 of group 1 only at D-7. The diagnostic accuracy of @entity688 and sCD25 was confirmed by the analysis of the AUROCC at D-1 and D-7 respectively. Multivariate analysis revealed that sCD25 and @entity688 are independent predictors of a poor outcome for our @entity1 during the first day of hospital admission. CONCLUSIONS: @entity688 and sCD25 gave a significant contribution to prognostic evaluation and early diagnosis of bacteremic @entity1850 . SOFA score appeared to be a reliable prognostic tool in this subset of @entity1 .

title: Impact of XXXX , soluble @entity2902 and @entity379 on the prognosis and early diagnosis of @entity1850 : a prospective observational study.

entities_list: @entity20960 :: ('MESH:C562780', 'Disease') :: ['immunodysregulation']

entities_list: @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS']

answer: @entity688 :: (3586,Gene) :: ['interleukin-10']


abstract: The objective of this study was to investigate the antibiotic resistance of @entity38885 isolated from commercial broiler @entity1573 farms. A total of 245 isolates from cloacal and cecal samples of 28- to 36-day-old @entity1573 were collected from 32 farms. Isolates were identified using PCR, and their susceptibility to 16 antibiotics was determined by disk diffusion assay. All isolates were susceptible to @entity2889 , @entity4509 , and @entity2177 . The most common resistances were against @entity869 (75.1%), @entity3639 (62.9%), and @entity803 (57.1%). Of the 184 @entity869 -resistant isolates, 127 were investigated using a DNA microarray carrying 75 probes for antibiotic resistance genetic determinants. Of these 127 isolates, the b-lactamase blaCMY2, blaTEM, blaACT, blaSHV, and blaCTX-M-15 genes were detected in 120 (94.5%), 31 (24.4%), 8 (6.3%), 6 (4.7%), and 4 (3.2%) isolates, respectively. Other detected genes included those conferring resistance to @entity581 (aadA1, strA, strB), trimethoprims (dfrV, dfrA1), @entity2930 ( @entity38886 , tetB, tetC, tetE), and @entity13135 (sul1, sul2). Class 1 integron was found in 35 (27.6%) of the @entity869 -resistant isolates. However, our data showed that the tested @entity38885 did not carry any carbapenemase blaOXA genes. Pulsed-field gel electrophoresis revealed that the selected @entity869 -resistant @entity38885 isolates were genetically diverse. The present study indicates that the monitoring of antimicrobial-resistant bacteria should include enteric bacteria such as @entity38885 , which could be a reservoir of antibiotic resistance genes. The detection of isolates harboring extended-spectrum b-lactamase genes, particularly blaCTX-M-15, in this work suggests that further investigations on the occurrence of such genes in broilers are warranted.

title: Antimicrobial Resistance of @entity38885 Isolated from Broiler XXXX .

entities_list: @entity2930 :: ('MESH:D013754', 'Chemical') :: ['tetracyclines']

entities_list: @entity13135 :: ('MESH:D013449', 'Chemical') :: ['sulfonamides']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem']

entities_list: @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin']

entities_list: @entity3639 :: ('MESH:D013307', 'Chemical') :: ['streptomycin']

entities_list: @entity1573 :: ('9031', 'Species') :: ['chickens', 'chicken']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity869 :: ('MESH:D000667', 'Chemical') :: ['ampicillin']

entities_list: @entity38885 :: ('564', 'Species') :: ['E. fergusonii', 'Escherichia fergusonii']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

answer: @entity1573 :: (9031,Species) :: ['Chickens']


abstract: INTRODUCTION: The ankle-brachial index (ABI), measurement of @entity2998 ( @entity2998 ), and assessment of the thickness of @entity22286 ( @entity22286 ), are noninvasive methods used to predict subclinical @entity731 in hemodialysis @entity1 . This study aimed to determine the prevalence of @entity3657 and to assess the correlations between ABI, @entity2998 , the thickness of @entity22286 , and blood parameters in hemodialysis @entity1 . MATERIALS AND METHODS: The ABI, @entity2998 , and the thickness of @entity22286 were measured in 50 @entity1 on hemodialysis. Data were collected regarding the levels of @entity460 , urine @entity1568 , low-density lipoprotein @entity165 , high-density lipoprotein @entity165 , @entity412 , @entity165 , @entity1011 , albumin in serum, as well as erythrocyte sedimentation rate. Results. Ten percent of the @entity1 showed a reduced ABI (< 0.9). The mean values for ABI, @entity2998 , and @entity22286 were 1.09    0.13, 0.68    0.11 mm, and 9.83    1.65 mm, respectively. The levels of @entity460 , @entity165 , low-density lipoprotein @entity165 , high-density lipoprotein @entity165 , and @entity412 in the serum of the @entity1 with normal ABI were significantly higher than in @entity1 with reduced ABI. There was a negative correlation between ABI and levels of serum LDLC (r = -0.29, P = .04) and @entity412 (r = -0.32, P = .02). Conclusions. The prevalence of @entity3657 in the @entity1 with @entity6192 was 10% and it was correlated with several classical risk factors for @entity731 , including elevated LDL and @entity165 levels. @entity2998 and the thickness of @entity22286 showed no apparent association with ABI.

title: Prevalence of XXXX in hemodialysis @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral arterial disease']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['CIMT', 'carotid artery intima-media thickness']

entities_list: @entity22286 :: ('MESH:C563239', 'Disease') :: ['IVS', 'interventricular septum']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity3657 :: (MESH:D058729,Disease) :: ['peripheral arterial disease']


abstract: BACKGROUND: The aim of this submission is to demonstrate the need for broad antimicrobial therapy, including empiric anti-fungal therapy, if rim-enhancing lesions are noted on cerebral imaging. METHODS: A retrospective microbiological and radiologic review of the management of a rare case of multiple @entity32843 and @entity2176 -resistant @entity6375 intra-cranial abscesses in an immunocompromised @entity1 was performed. A manual chart review assessing clinical and epidemiologic characteristics was completed including procedures and operative notes, use of invasive devices, biochemical and haematological blood test results, antimicrobial agents received, and documentation of a travel history. RESULTS: Antimicrobial therapy combined with source control, typically surgical drainage, is considered the gold standard management of an intra-cranial abscess. Fungal abscesses produce rim-enhancing lesions, and where this radiographic feature is identified, evidence suggests that anti-fungal agents should be added. Antimicrobial therapy with @entity5136 and @entity18111 failed, and the @entity1 died. There was extensive disease progression evident on serial imaging despite therapy. A definitive surgical drainage procedure could not be performed. CONCLUSIONS: Interval imaging assisted with the management of this challenging case. A low index of clinical suspicion for fungal intra-cerebral abscesses is necessary when treating immunosuppressed @entity1 .

title: Beware of Rim-Enhancing Lesions: A Rare Case of Multiple XXXX and @entity2176 -Resistant @entity6375 Intra-Cranial Abscesses.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity32843 :: ('563466', 'Species') :: ['Scedosporium apiospermum']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity6375 :: ('1352', 'Species') :: ['Enterococcus faecium']

entities_list: @entity18111 :: ('MESH:D065819', 'Chemical') :: ['voriconazole']

entities_list: @entity5136 :: ('MESH:C098010', 'Chemical') :: ['linezolid']

answer: @entity32843 :: (563466,Species) :: ['Scedosporium apiospermum']


abstract: The @entity238 somatic mutation and recombination test (SMART) was used to assess the genotoxicity of surface (S) and bottom (B) water and sediment samples collected from Sites 1 and 2 on the Japaratuba River (Sergipe, Brazil), an area impacted by a petrochemical industrial complex that indirectly discharges treated effluent (produced water) into the river. The genotoxicity tests were performed in standard (ST) cross and @entity2101 ( @entity2101 ) cross flies and were conducted on samples taken in March (dry season) and in July (rainy season) of 2003. Mutant spot frequencies found in treatments with unprocessed water and sediment samples from the test sites were compared with the frequencies observed for similar samples taken from a clean reference site (the Jacarecica River in Sergipe, Brazil) and those of negative (ultrapure water) controls. While samples from the Japaratuba River generally produced greater responses than those from the Jacarecica River, positive responses were detected for both the test and reference site samples. All the water samples collected in March 2003 were genotoxic. In July 2003, the positive responses were restricted to water samples collected from Sites 1 B and 2 S in the ST cross. The genotoxicity of the water samples was due to mitotic recombination, and the samples produced similar genotoxic responses in ST and @entity2101 flies. The spot frequencies found in the July water samples were considerably lower than those for the March water samples, suggesting a seasonal effect. The only sediment samples that were genotoxic were from Site 1 (March and July) and from the Jacarecica River (March). The genotoxins in these samples produced both somatic mutation (limited to the Site 1 sample in @entity2101 flies) and recombination. The results of this study indicate that samples from both the Japaratuba and Jacarecica Rivers were genotoxic, with the most consistently positive responses detected with Site 1 samples, the site closest to the putative pollution source.

title: Assessing the impact of pollution on the Japaratuba river in Brazil using the XXXX wing spot test.

entities_list: @entity2101 :: ('MESH:C538394', 'Disease') :: ['high bioactivation', 'HB']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila melanogaster']

answer: @entity238 :: (7227,Species) :: ['Drosophila']


abstract: CONTEXT: The development of @entity3 is the most notable characteristic of malignant @entity5 . The filter function of lymph nodes, which led to the idea of including lymphatic treatment in surgical management of @entity3 . OBJECTIVES: To evaluate morphological alterations in neck nodes in the presence of differentiated @entity259 (DTC): @entity1373 , @entity22964 , desmoplasia, capsular @entity397 , @entity39 and their relation to the biological behavior of these @entity5 . DESIGN: Retrospective study. SETTING: University referral unit. @entity1 : 98 DTC @entity1 , from 1977 to 1992, 18 cases were selected for histological analyses, of which 14 were female and 4 males, with an average age of 50.2 years. From these cases, 290 lymph nodes were analyzed (81 with @entity3 ), with an average of 16 lymph nodes/ @entity1 . MAIN MEASUREMENTS: Morphological evaluation of paraffin cuts stained by HE was done using an optical microscope, looking for presence of the above mentioned @entity5 and their UICC-TNM (1997) staging. RESULTS: Sinus @entity22964 was 2.4 times more frequent in the absence of lymph node @entity3 (pNo). Disease recurrence occurred in 5 @entity1 , all of whom were more than 40 years old (p= 0.24) and 4 of whom had @entity39 (p= 0.02). Six @entity1 with predominance of paracortical @entity1373 (p= 0.02) did not show as much relapse into disease as those with less than 6 @entity3 lymph nodes (p= 0.009). CONCLUSIONS: The presence of paracortical @entity1373 is associated with a better prognosis. The existence of @entity39 or @entity3 in more than 6 lymph nodes in @entity1 over 40 years of age is related to higher risk of relapse of disease in DTC.

title: Evaluation of lymph node reactivity in differentiated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity22964 :: ('MESH:D015614', 'Disease') :: ['histiocytosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasias']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma']

answer: @entity259 :: (MESH:D013964,Disease) :: ['thyroid carcinoma']


abstract: BACKGROUND: This study aimed to determine the efficacy of @entity1346 gel (Cica-Care) on severe post-traumatic @entity2318 among the Chinese population. METHOD AND MATERIALS: A randomized clinical trial (RCT) was conducted on 45 Chinese @entity1 with post-traumatic @entity2805 . Twenty-two subjects were placed in the experimental group with @entity1346 gel sheeting (SGS) applied 24h per day for 6 months while all subjects were taught to massage the scar daily for 15 min serving as the control intervention. Scar assessments were conducted regularly to measure the changes in thickness, @entity2118 , vascularity, pliability, itchiness and @entity158 . RESULTS: Two-way repeated ANOVA showed a significant difference between MT group and SGS group on scar thickness. The post hoc comparison analysis showed that the difference was significant at the post-2-month (p=0.008) and post-6-month (p<0.001) intervention. The SGS group also showed changes in @entity2118 which resembled normal skin but no statistical significance was found. @entity158 , itchiness and pliability were also improved after intervention. CONCLUSION: This study indicated that @entity1346 gel sheeting (Cica-Care) was effective to reduce thickness, @entity158 , itchiness and pliability of the severe @entity2805 among the Chinese population. The moisturization effect of the tough and hard scar might contribute to the reduction of the skin thickness after 6 month's intervention.

title: A prospective randomized clinical trial to investigate the effect of XXXX gel sheeting (Cica-Care) on post-traumatic @entity2805 among the Chinese population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2318 :: ('MESH:D002921', 'Disease') :: ['hypertophic scars']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigmentation']

entities_list: @entity2805 :: ('MESH:D017439', 'Disease') :: ['hypertrophic scars', 'hypertrophic scar']

answer: @entity1346 :: (MESH:D012828,Chemical) :: ['silicone']


abstract: OBJECTIVES: Despite improved treatment strategies for @entity309 ( @entity309 ), some patients do not respond satisfactorily. The aim of this study was to investigate the course and outcome of early @entity309 diagnosed during the 1990s and followed for 8  years with a focus on those who did not respond well to treatment. METHOD: This study included 640 patients (66% women) who were enrolled in the BARFOT (Better Anti-Rheumatic PharmacOTherapy) @entity309 inception cohort between the years 1993 and 1999. The 28-joint count Disease Activity Score (DAS28) <  2.6 criteria were used to assess remission. @entity66 ( @entity66 ) was defined as absence of remission at all predefined follow-up visits at 1, 2, 5, and 8  years. Function was assessed by Health Assessment Questionnaire (HAQ) and Signals of Functional Impairment (SOFI) scores and radiological joint damage by the @entity558 ( @entity558 ). RESULTS: Of the 640 patients, 214 (37%) had @entity66 (43% of the women and 25% of the men). Over the 8  years of follow-up, patients with @entity66 had significantly worse mean values for patient's global health measured on a visual analogue scale (VAS patGH), @entity158 , HAQ, SOFI, and @entity558 compared with those in the non- @entity66 group. Multivariate logistic regression analyses revealed that female gender, current smoking, disease activity at baseline, and absence of remission at 6 months independently predicted @entity66 . CONCLUSIONS: Of the patients who entered the early @entity309 inception cohort, 37% suffered a @entity66 course over 8  years. The consequences of @entity66 with regard to general health, @entity158 , function, and joint damage were considerable. Of note, @entity66 was more common in women than in men.

title: Persistently active disease is common in patients with XXXX , particularly in women: a long-term inception cohort study.

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['Sharp/van der Heijde score', 'SHS']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['VAS pain', 'pain']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['PD', 'Persistent disease']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: @entity2976 ( @entity2976 ) is recognized as a serious complication of peritoneal dialysis. However, recovery is possible if an appropriate diagnosis and treatment are made. The term @entity2976 is used most often, but is inaccurate, particularly the reference to @entity298 . A more accurate description would be "encapsulating peritoneal @entity1463 " ( @entity2976 ). From the therapeutic perspective, the diagnosis should be established before @entity2976 develops. Early diagnosis is important. Furthermore, it is also important to determine the therapeutic tactics for @entity2976 according to the disease stage. Most cases of @entity2976 develop with manifestations of fever, increased levels of @entity1851 ( @entity1851 ), and slight @entity1109 , accompanied by @entity843 ("inflammatory stage"). Following precise identification of the inflammatory stage, @entity134 administration should be initiated immediately with the onset of @entity2976 . @entity1667 pulse therapy is recommended during the early stage. If the @entity2976 is not relieved, or if it recurs within 1 month, the @entity134 dose should be decreased and the @entity1 should be managed by total parenteral nutrition (TPN) ("encapsulating stage"). If @entity1109 remain despite the absence of inflammatory findings and decreased ascites, laparotomy and enterolysis should be considered within 6 months ("ileus stage"). However, it is important that the enterolysis be performed without damaging the capsule-covered intestine. To date, we have successfully treated @entity2976 in 18 of 19 @entity1 using these options. In 3 @entity1 , @entity2976 was relieved by @entity134 administration. In 15 @entity1 , @entity2976 was relieved by total intestinal enterolysis. Enterolysis @entity1 had satisfactory operative outcomes and eventually returned to their previous social activities. One @entity1 experienced perforation of the small intestine and pan- @entity298 , and died of @entity295 . In summary, @entity2976 is not an incurable disease. It can be completely overcome by active diagnosis and treatment.

title: Treatment options for encapsulating peritoneal XXXX based on progressive stage.

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['Methylprednisolone']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2976 :: ('MESH:D056627', 'Disease') :: ['EPS', 'Sclerosing encapsulating peritonitis', 'SEP']

entities_list: @entity843 :: ('MESH:D001201', 'Disease') :: ['increased ascites']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['ileus symptoms']

entities_list: @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritonitis']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1463 :: (MESH:D012598,Disease) :: ['sclerosis']


abstract: This study examines the effectiveness of the ' @entity20363 ' ( @entity734 Rehabilitation Center) and its program in treating @entity1 with @entity734 . @entity20363 is the only rehabilitation facility group managed by recovered drug users in Japan. It uses the 'Twelve Step Program' as part of its recovery regime. Through structured questionnaires, the changes of @entity1 ' and ex- @entity1 ' everyday behavior, their acceptance of spirituality, attitude toward drugs, self-esteem, their coping skills and loneliness were examined. The results revealed: a.. Negative partial correlation between loneliness and everyday behavior. b.. Negative partial correlation between loneliness and positive/effective coping skills. c.. Positive partial correlation between acceptance of 'spirituality' and attitude toward drugs. d.. Positive partial correlation between acceptance of 'spirituality' and positive/effective coping skills. These results suggest that the acceptance of 'spirituality' and decreasing loneliness are important factors in the recovery from @entity734 .

title: [A study of recovery factor about drug addiction recovery center " XXXX "].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['drug dependence', 'Drug Addiction']

answer: @entity20363 :: (2532,Gene) :: ['DARC']


abstract: OBJECTIVE: We compared the Diamond-Forrester (DF) tabular method to assess pretest probability of @entity453 to a new scoring method (NS). METHODS: We evaluated 544 @entity1 with suspected @entity301 who underwent both exercise electrocardiography and coronary angiography. The prevalence of any @entity453 ( @entity453 ) (>/=1 vessel with a >/=50% stenosis) within low, intermediate, and high pretest probability groups defined by the 2 methods was compared. The DF method used age, sex, and symptoms. The NS used those 3 factors plus 7 other risk factors. RESULTS: Overall prevalence of @entity453 was 41%. We compared the respective prevalence of @entity453 within pretest probability groups. Low probability: DF 27% versus NS 17% (P <.03); intermediate probability: DF 42% versus NS 47%; high probability: DF 70% versus NS 72%. We evaluated results separately in @entity1 and @entity1 . In @entity1 , no significant differences were found. However, in @entity1 , a significant difference in the low probability group was found (DF 47% versus NS 22%; P <.03). When the 47 asymptomatic @entity1 were removed from the analysis, there were no differences between the 2 methods. @entity1 : low probability, DF 17% versus @entity37913 %; intermediate probability, DF 45% versus @entity37914 %; high probability, DF 67% versus NS 72%. @entity1 : low probability, DF 17% versus NS 15%; intermediate probability, DF 38% versus NS 27%; high probability, DF 83% versus NS 70%. CONCLUSION: In symptomatic @entity1 , the accuracy of the 2 methods was the same. In asymptomatic @entity1 , further evaluation in larger populations will be needed.

title: Comparison of the Diamond-Forrester method and a new score to estimate the pretest probability of XXXX before exercise testing.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'Men', 'men']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

answer: @entity301 :: (MESH:D003327,Disease) :: ['coronary disease']


abstract: AIMS: Following a large @entity583 ( @entity583 ), remaining viable muscle often undergoes pathological remodelling and progresses towards chronic @entity712 . Mitochondria may also be affected by this process and, due to their functional importance, likely contribute to the progression of the disease. Aerobic interval training (AIT) has been shown effective in diminishing pathological myocardial transformation, but the effects of AIT on mitochondrial function in hearts undergoing remodelling are not known. METHODS AND RESULTS: Adult female @entity35 were randomized to either 8 weeks of aerobic interval treadmill running (5 days/week), which started 4 weeks after left coronary artery ligation ( @entity583 -Trained), or a sedentary group ( @entity583 -Sedentary). Echocardiography was performed before and after the 8-week period, at which point the left ventricles (LVs) were also harvested. Twelve weeks after surgery, @entity583 -Sedentary @entity35 had significantly lower LV fractional shortening compared with @entity583 -Trained @entity35 . Complex I-dependent respiration assessed in isolated LV mitochondria was decreased by    37% in @entity583 -Sedentary and 17% in @entity583 -Trained animals (group differences P < 0.05), compared with sham-operated animals. This was paralleled with diminished @entity855 production and increased degree of protein oxidation in @entity583 -Sedentary @entity35 . The enzymatic activity of complex I was also decreased to a greater extent in @entity583 -Sedentary than in @entity583 -Trained animals, with no evidence of its reduced expression. When complex II substrate was used, no differences among the three groups were observed. CONCLUSION: Exercise reduces LV contractile deterioration in post- @entity1188 @entity712 and alleviates the extent of @entity2383 , which is paralleled with preserved complex I activity.

title: Aerobic interval training attenuates remodelling and @entity2383 in the post- @entity1188 failing XXXX heart.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: @entity21168 isolates associated with recent outbreaks of @entity1576 in Ontario and Quebec dairy farms were compared to reference strains known to be responsible for neonatal calf @entity294 (NCD) or @entity5163 ( @entity5163 ) of adult @entity291 . In respect to their hemagglutinating properties and their higher RDE activities with @entity35 erythrocytes, WDBCoV strains differed from NCDBCoV strains and respiratory @entity291 coronaviruses RBCoV strains. Serologically, three MAbs directed to the HE glycoprotein of the WDBCoV strain BCQ.2590 recognized two serogroups amongst NCDBCoV strains by hemagglutination inhibition, whereas only one of the MAbs failed to react toward three of the four RBCoV isolates tested. Sequencing analysis of the S (S1 portion), HE, ORF4 and ORF5 genes of BCoV isolates associated with different clinical syndromes indicated that neither insertions or deletions could explain their distinct tropism. For the HE glycoprotein, a total of 15 @entity1522 (aa) substitutions were identified by comparing field isolates to the prototype Mebus strain. Two specific @entity1521 substitutions were identified for virulent strains being located in the signal peptides (aa 5) and aa position 367; one specific aa change was revealed at position 66 for RBCoV field isolates. Analysis of the S1 portion of the S glycoprotein revealed a total of eight aa changes specific to enteropathogenic (EBCoV) strains and eight aa changes specific to RBCoV strains. For all BCoV isolates studied, the region located between the S and M genes (ORF4) apparently encodes for two non-structural (ns) proteins of 4.9 and 4.8 kDa. A specific non-sense mutation was identified for the @entity377 at position 88 of the putative 4.9 kDa protein gene of RBCoV isolates resulting in 29 rather that 43 aa residues. The ORF5, which encodes a 12.7 ns protein and the 9.5 kDa E protein, was highly conserved amongst the BCoV field isolates.

title: @entity291 coronaviruses associated with enteric and XXXX in Canadian dairy @entity291 display different reactivities to anti-HE monoclonal antibodies and distinct amino acid changes in their HE, S and ns4.9 protein.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity21168 :: ('11128', 'Species') :: ['Bovine coronavirus']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity5163 :: ('MESH:D004403', 'Disease') :: ['WD', 'winter dysentery']

answer: @entity1576 :: (MESH:D012131,Disease) :: ['respiratory diseases']


abstract: OBJECTIVE: To examine the characteristics of @entity1 seeking @entity249 evaluation and treatment. DESIGN: Cross-sectional survey based on in- @entity1 interviews, followed by two-step hurdle analysis. SETTING: Not applicable. @entity1 (S): 4,558 married or cohabitating @entity1 ages 25 to 44 years. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Likelihood of seeking a preliminary @entity249 evaluation and of seeking @entity249 treatment once evaluated, and the treatment type provided. RESULT(S): Of 623 @entity1 (13.7%) who reported seeking an @entity249 evaluation, 328 reported undergoing subsequent @entity249 treatment. Age at marriage, marital status, education, health insurance status, race/ethnicity, and religion were associated with the likelihood of seeking @entity249 evaluation. For example, the predicted probability that a non-white @entity1 who married at age 25 will seek evaluation was 12%. This probability increased to 34% for white @entity1 with a graduate degree who had married at age 30. Among @entity1 who were evaluated, income, employment status, and ethnicity correlated strongly with the likelihood of seeking @entity249 treatment. Infertility drug therapy was the most frequent treatment used, and reproductive surgery and @entity52 ( @entity52 ) were used the least often. CONCLUSION(S): The use of @entity249 services is not random. Understanding the sociodemographic factors correlated with use may assist new couples with family planning. Roughly 50% of the @entity1 evaluated for @entity249 progressed to treatment, and only a small proportion were treated with more advanced assisted reproductive technologies such as @entity52 . Future research aimed at improving access to effective health-care treatments within the boundaries of affordability is warranted.

title: Infertility evaluation and treatment among XXXX in the United States.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'person', 'PATIENT']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['in vitro fertilization', 'IVF']

answer: @entity1 :: (9606,Species) :: ['women']