abstract: @entity2008 have biologic and prognostic significance in @entity1582 , especially among @entity1 with @entity66 . We report the relationship between @entity2008 and known prognostic factors such as plasma cell labeling index (PCLI) and bone marrow plasma cell involvement in 75 consecutive @entity1 undergoing autologous stem cell transplantation for relapsed or refractory @entity1582 . Thirty of 70 @entity1 (43%) had a chromosomally abnormal clone in their bone marrow, and in most cases the karyotype was complex (> 3 abnormalities). @entity1 with an abnormal clone on cytogenetic analysis had a higher PCLI (median, 1.4) than @entity1 with a normal karyotype (0.2) (P < 0.001). Bone marrow plasma cell percentage also differed: median 48% versus 20%, respectively (P < 0.001). The PCLI and bone marrow plasma cell percentage correlated positively with the percentage of abnormal metaphases on conventional cytogenetic analysis: rho 0.60 (P < 0.001) and 0.46 (P < 0.001), respectively. We categorized @entity1 into those with 20% or more abnormal metaphases, less than 20% abnormal metaphases, and only normal metaphases. The median PCLI values were 3.3, 1.1, and 0.3, respectively (P < 0.001). The bone marrow plasma cell percentage median values were 62%, 40%, and 25%, respectively (P = 0.003). @entity2008 may offer a proliferative advantage to the neoplastic plasma cell, thereby leading to an unfavorable outcome.

title: @entity2008 correlate with the plasma cell labeling index and extent of bone marrow involvement in XXXX .

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'myeloma']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities', 'Chromosomal abnormalities']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['relapsed disease']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['myeloma']


abstract: The selective @entity4645 ( @entity4645 ) and @entity12032 ( @entity12032 ) inhibitors might inhibit @entity3009 synthesis and reduce @entity644 . The present study was designed to investigate the anti-proteinuric effects of @entity2604 ( @entity2605 ) as compared with @entity12698 in @entity8424 ( @entity7540 ) @entity3450 @entity35 . Fifty five male @entity35 were divided into 4 groups; A, normal control; B, @entity7540 group; C, @entity7540 + @entity4645 inhibitor ( @entity12698 ) group; and D, @entity7540 +5- @entity12032 inhibitor ( @entity2605 ) group. After induction of @entity7540 @entity3450 through repeated injections of @entity7540 (7.5 and 15 mg/100 g body weight), @entity35 were treated with @entity12698 , @entity2605 , or vehicle for 2 weeks. Twenty four hour urine protein excretions were significantly lower in @entity7540 + @entity12698 and @entity7540 + @entity2605 groups than in @entity7540 group. Serum @entity1011 (SCr) concentrations and 24 hr urine @entity1011 clearances (CCr) were not significantly different in the four groups. Electron microscopy showed that podocyte morphology was changed after the induction of @entity7540 @entity3450 and was recovered after @entity12698 or @entity2605 administration. @entity12698 significantly recovered the expressions of nephrin, @entity32247 , @entity4645 , and @entity1810 . @entity2605 also recovered @entity1810 expression, but did not alter the expressions of nephrin, @entity32247 and @entity4645 . The present study suggested that @entity12698 and @entity2605 might effectively reduce @entity644 in @entity1985 without @entity8 .

title: Effects of @entity12698 and @entity2604 on XXXX -induced @entity3450 in the @entity35 .

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome']

entities_list: @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib', 'Celecoxib']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['impairing renal function']

entities_list: @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin']

entities_list: @entity2604 :: ('MESH:D009637', 'Chemical') :: ['nordihydroguaiaretic acid']

entities_list: @entity3450 :: ('MESH:D009401', 'Disease') :: ['nephrosis']

entities_list: @entity8424 :: ('MESH:D011692', 'Chemical') :: ['puromycin aminonucleoside']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

answer: @entity8424 :: (MESH:D011692,Chemical) :: ['puromycin aminonucleoside']


abstract: This study was designed to evaluate the efficacy and safety of computed tomography (CT)-guided drainage in treating infected collections due to @entity356 after laparoscopic sleeve gastrectomy for morbid @entity28 . From January 2007 to June 2009, 21 @entity1 (9 @entity1 and 12 @entity1 ; mean age, 39.2 (range, 26-52) years) with infected collections due to @entity356 after laparoscopic sleeve gastrectomy for morbid @entity28 underwent image-guided percutaneous drainage. All procedures were performed using CT guidance and 8- to 12-Fr pigtail drainage catheters. Immediate technical success was achieved in all 21 infected collections. In 18 of 21 collections, we obtained progressive shrinkage of the collection with consequent clinical success (success rate 86%). In three cases, the abdominal fluid collection was not resolved, and the @entity1 were reoperated. Among the 18 @entity1 who avoided surgery, 2 needed replacement of the catheter due to obstruction. No major complications occurred during the procedure. The results of our study support that CT-guided percutaneous drainage is an effective and safe method to treat infected abdominal fluid collections due to @entity356 in @entity1 who had previously underwent laparoscopic sleeve gastrectomy for morbid @entity28 . It may be considered both as a preparatory step for surgery and a valuable alternative to open surgery. Failure of the procedure does not, however, preclude a subsequent surgical operation.

title: CT-guided percutaneous drainage of infected collections due to @entity356 after sleeve gastrectomy for morbid XXXX : initial experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric leak']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: AIMS: Although @entity943 surgery and radiofrequency catheter ablation to cure @entity2917 reentrant @entity591 differ in technical concept, the late results of both methods, in terms of elimination of the arrhythmogenic substrate and procedure-related new and different @entity943 , have never been compared. This constituted the purpose of this prospective follow-up study. METHODS AND RESULTS: Between 1988 and 1992, 26 @entity1 were surgically treated using perinodal dissection or 'skeletonization', and from 1991 up to 1995, 120 @entity1 underwent radiofrequency modification of the atrioventricular node for @entity2917 reentrant @entity591 . The acute success rates of surgery and radiofrequency catheter ablation were 96% and 92%, respectively. Late recurrence, rate in the surgical and radiofrequency catheter ablation groups was 12% and 17%, respectively. Mean follow-up was 53 months in the surgical group and 28 months in the radiofrequency catheter ablation group. The final success rate after repeat intervention was 100% in the surgical group and 98% in the radiofrequency catheter ablation group. Comparison of the initial and recent series of radiofrequency catheter ablated @entity1 showed an increased initial success rate with fewer applications. In the radiofrequency catheter ablation group, a second- or third-degree block developed in three @entity1 (2%), requiring permanent pacing, whereas in the surgical group no complete @entity713 was observed. Inappropriate sinus @entity591 needing drug treatment was observed in 13 @entity1 (11%), mostly after fast pathway ablation, but was never observed after surgery. New and different supraventricular @entity591 arose in 27% of the @entity1 in the surgical group and in 11% of the radiofrequency catheter ablation group, but did not clearly differ. CONCLUSION: This one-institutional follow-up study demonstrated comparable initial and late success rates as well as incidence of new and different @entity943 following @entity943 surgery and radiofrequency catheter ablation for @entity2917 reentrant @entity591 . Today radiofrequency catheter ablation has replaced @entity943 surgery for various reasons, but the late arrhythmic side-effects warrant refinement of technique.

title: Comparison of late results of surgical or radiofrequency catheter modification of the atrioventricular node for XXXX reentrant @entity591 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2917 :: ('MESH:D013611', 'Disease') :: ['atrioventricular nodal']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia', 'tachyarrhythmias']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['supraventricular arrhythmias', 'arrhythmias', 'arrhythmia']

answer: @entity2917 :: (MESH:D013611,Disease) :: ['atrioventricular nodal']


abstract: On the basis of a review of the literature and five case histories, the pathophysiological and clinical features in pregnant @entity1 with haemolysis, elevated liver enzymes and @entity882 which together constitute the @entity2102 (haemolysis, elevated liver enzymes and low platelet count) are illustrated. This syndrome describes a complicated obstetric course with greatly increased neonatal and maternal morbidities. @entity101 / @entity644 are common but are not obligatory. The condition should be suspected in pregnant @entity1 with @entity158 under the right rib margin and unexplained @entity1087 . The diagnosis is verified by the blood picture, liver enzyme count and a blood smear. @entity1 with verified @entity2102 and gestational age greater than 34 weeks should be delivered immediately. @entity1 with the same syndrome and gestational age less than 32 weeks should be delivered if the condition cannot be rapidly controlled. In exceptional cases cesarean section may be necessary. On the basis of the coagulation status, the defective plasma components may be supplied (e.g. fresh frozen plasma and antithrombin-III). Plasmapheresis and specific pharmacological intervention must be considered as experimental at present, although these present promising therapeutic possibilities.

title: [Hemolysis, elevated liver enzymes and XXXX : the @entity2102 --a manifestation of severe pre-eclampsia].

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP syndrome']

answer: @entity882 :: (MESH:D013921,Disease) :: ['thrombocytopenia']


abstract: AIMS: The goal of this study was to isolate and characterize a @entity880 bacteria (LAB) from @entity15382 milk with potential beneficial properties. METHODS AND RESULTS: Lactic acid bacteria were isolated from @entity15382 milk and identified based on physiological, biochemical and molecular methods. The isolate that presented highest @entity5618 potential ( @entity1336 LP08AD) was evaluated for the production of @entity5618 , including stability in the presence of various enzymes, surfactants, salts, pH and temperatures. Bactericidal effect of @entity5618 LP08AD on @entity5125 , @entity6375 and @entity20201 was shown for actively growing and stationary cells. Similar growth and @entity5618 production were observed when strain LP08AD was cultured in @entity7748 broth at 30  C or 37  C. @entity5618 LP08AD adhered at low levels on the producer cells (200  AU  ml(-1) ). The presence of plantaricin W gene on the genomic DNA was recorded based on PCR. Good growth for strain LP08AD was recorded in @entity7748 broth with pH from 5  0 to 9  0 and LP08AD grew well in the absence of oxbile or concentration below 0  8%. Lact.  plantarum LP08AD was applied to the small intestinal epithelial polarized monolayers of H4, PSIc1 and CLAB and demonstrated low attachment ability on all cell lines studied, with values with a similar behaviour for cells from @entity1 and @entity1707 origin. CONCLUSIONS: @entity5618 -producing Lact.  plantarum LP08AD might be useful in the design of novel functional foods with potential probiotic or biopreservation properties. SIGNIFICANCE AND IMPACT OF THE STUDY: To the best of our knowledge, this is the first report on detection and characterization of bacteriocinogenic Lact.  plantarum from @entity15382 milk. The strain LP08AD shows to have potential beneficial properties, as demonstrated by the use of noncancerogenic cell lines.

title: Isolation and identification of bacteriocinogenic strain of @entity1336 with potential beneficial properties from XXXX milk.

entities_list: @entity5618 :: ('CHEBI:48081', 'Chemical') :: ['Bacteriocin', 'bacteriocin']

entities_list: @entity5125 :: ('1639', 'Species') :: ['Listeria monocytogenes']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

entities_list: @entity6375 :: ('1352', 'Species') :: ['Enterococcus faecium']

entities_list: @entity20201 :: ('28038', 'Species') :: ['Lactobacillus curvatus']

entities_list: @entity1336 :: ('1590', 'Species') :: ['Lactobacillus plantarum']

answer: @entity15382 :: (9793,Species) :: ['donkey']


abstract: Induction of transcription of the immediate-early (IE) genes of herpes simplex virus involves the assembly of a DNA-binding complex containing the viral protein Vmw65 and the cellular transcription factor @entity20170 . We show that @entity20170 is not sufficient for complex formation and that another cellular factor(s) which is absolutely required for complex formation can be separated from @entity20170 under native conditions. We have purified this factor by approximately 100-fold using DNA-cellulose, ion-exchange and size-exclusion chromatographies. The assay used throughout the purification procedure follows the ability of the cellular factor to form a complex when added to purified @entity20170 , Vmw65 and an IE specific DNA probe. The @entity27392 ( @entity27392 ) had a sedimentation coefficient of about 4.4 S (i.e. molecular mass of about 70K, under non-denaturing conditions) and the polypeptide profile of highly purified @entity27392 demonstrated two major species with molecular masses of 80K and 70K. Unequivocal association of either of these two species with @entity27392 activity could not presently be demonstrated due to the sensitivity of @entity27392 to denaturation. @entity27392 , when tested on its own or in the presence of Vmw65, did not bind to the IE-specific consensus motif. We have also used deletion mutants of @entity20170 to show that the POU domain of this protein was sufficient for @entity27392 -dependent complex formation with Vmw65. Deletions of the POU specific region of @entity20170 significantly reduced the complex forming ability, although detectable levels of complex were reconstituted using Vmw65, @entity27392 and just the homeodomain of @entity20170 .

title: Characterization of a cellular factor which interacts functionally with XXXX in the assembly of a multicomponent transcription complex.

entities_list: @entity27392 :: ('3054', 'Gene') :: ['complex forming factor', 'CFF']

answer: @entity20170 :: (5451,Gene) :: ['Oct-1']


abstract: AIMS: This paper describes a modified surgical approach of the minimally invasive surgical technique (modified minimally invasive surgical technique, M-MIST) and preliminarily evaluates its applicability and clinical performances in the treatment of isolated @entity427 in combination with amelogenins. MATERIAL AND METHODS: Twenty deep isolated @entity154 in 20 @entity1 were studied. Fifteen were surgically accessed with the M-MIST, while in five sites, which presented a lingual intrabony component, the conventional MIST had to be applied. The M-MIST consisted of a buccal incision of the @entity154 , according to the principles of the papilla preservation techniques. Only a buccal flap was raised while the interdental papilla was left in situ. The granulation tissue filling the defect was dissected and removed, leaving the interdental and palatal tissues untouched. Root instrumentation and application of the regenerative material were performed before suturing. Primary closure of the flaps was attained with a single internal modified mattress suture. Surgery was performed with the aid of an operating microscope and microsurgical instruments. RESULTS: The surgical chair-time of the M-MIST-treated sites (N=15) was 56+/-8.64 min. Early wound healing was uneventful: primary wound closure was attained and maintained in all sites. No @entity4 or haematoma was noted. @entity1 did not report @entity158 or discomfort. The 1-year clinical attachment level (CAL) gain was 4.5+/-1.4 mm in defects 6+/-1.5 mm deep. Residual probing depths (PDs) were 3.1+/-0.6 mm. A minimal increase of 0.1+/-0.3 mm in gingival recession between baseline and 1 year was observed. CONCLUSIONS: M-MIST was applicable on 15 isolated interproximal defects out of 20 selected ones. It resulted in very limited @entity1 morbidity and excellent clinical improvements. These outcomes should be confirmed in a larger study.

title: Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['defect-associated papilla', 'intrabony defects']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity427 :: ('MESH:D012021', 'Disease') :: ['deep intrabony defects']

answer: @entity154 :: (MESH:D000013,Disease) :: ['interdental intrabony defects']


abstract: The most recent American Joint Committee on @entity5 /International Union Against @entity5 (AJCC/UICC) staging system subgroups @entity1 into one to three and four or more positive nodes. However, the Gastrointestinal Study Group and the National Surgical Adjuvant Breast and Bowel Project divides node-positive @entity1 into one to four and five or greater. A Cox multi-variate retrospective analysis was done of the overall survival of node-positive @entity694 @entity1 with the specific objective of determining the most appropriate subcategorization. Data on 306 @entity1 with node-positive @entity694 who underwent potentially curative surgery from 1970 to 1984 were analyzed retrospectively. No @entity1 received adjuvant chemotherapy. Also excluded were @entity1 with synchronous resected metastatic disease or those with rectal primaries. The median follow-up was 6 years, and the median survival for the entire group was 8.6 years. By univariate analysis, the following were significant prognostic features: number of positive nodes (P less than 0.0001), degree of differentiation (P less than 0.0001), colon primary site (P = 0.009), @entity5 stage (P = 0.001), and @entity5 size (P less than 0.0001). Lymphatic/blood vessel invasion and a mucinous histology were not significant. By Cox multivariate analysis the number of positive lymph nodes remained the best discriminant of survival (P = 0.0001). The number of positive nodes was related inversely to prognosis with the optimal dichotomization between one to three (66% 5-year survival) and four or greater nodes (37% 5-year survival).

title: Prognosis of node-positive XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: PURPOSE: @entity101 is a common adverse effect of @entity7 ( @entity7 ) signaling inhibitors, such as bevacizumab, with an incidence upwards of 35%. The management of bevacizumab-induced @entity101 is important in order to avoid dose interruption/discontinuation and/or end organ damage. The efficacy of antihypertensive medications for this cause of @entity101 has not been demonstrated. This study seeks to determine if antihypertensives are effective in treating anti- @entity7 -induced @entity101 from bevacizumab and determine which classes of antihypertensive agents are effective. METHODS: A retrospective review of all @entity1 who received bevacizumab between January 2007 and September 2009 at two medical centers was conducted. @entity1 were included if they experienced new onset or exacerbation of preexisting @entity101 , during bevacizumab treatment. Efficacy of antihypertensives was determined by recording a 28-day change in systolic blood pressure from the initiation or dose increase of individual antihypertensive medications. Secondary endpoints included an efficacy analysis of antihypertensive classes. RESULTS: Five-hundred thirteen @entity1 were identified as receiving bevacizumab during the indicated time period. Fifty-seven @entity1 met the full inclusion/exclusion criteria for analysis. The average systolic blood pressure declined by 23    mm   Hg with 4 weeks of treatment (p   <   0.0001). Each class had a statistically significant decline in systolic blood pressure of 15.5-57 mm   Hg with the exception of diuretics and a group of miscellaneous antihypertensives. CONCLUSIONS: This is the first data that demonstrates individual classes of antihypertensives are effective in bevacizumab-induced @entity101 . Most antihypertensives were effective in reducing blood pressure, with the exception of diuretics and miscellaneous antihypertensives, which may be due to a limited sample size.

title: Blood pressure control in XXXX receiving bevacizumab in an outpatient cancer center.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A 27-year-old @entity1 was admitted to our ICU with @entity1576 and criteria for @entity649 . Despite an F(IO(2)) of 1.0 and a lung protective strategy, the @entity1 died on day 15 without any improvement. The relatives gave consent for post-mortem analysis. The histopathologic study of the lung showed findings typical of an acute fibrinous and @entity3616 . Apropos of this case we performed a PubMed search. We found 13 articles, including a total of 29 @entity1 . Acute fibrinous and @entity3616 is an unusual cause of @entity647 . The diagnostic criterion is histopathologic. There is little information regarding the pathophysiology of this illness. Important questions remain regarding this disease, including predisposing factors and management. @entity1 who require mechanical ventilation have poor outcomes.

title: Severe acute @entity1576 secondary to acute fibrinous and XXXX requiring mechanical ventilation: a case report and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'woman', 'patients', 'patient']

entities_list: @entity3616 :: ('MESH:D018549', 'Disease') :: ['organizing pneumonia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['acute hypoxemic respiratory failure']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']

answer: @entity3616 :: (MESH:D018549,Disease) :: ['organizing pneumonia']


abstract: BACKGROUND: The use of Serious exerGames (SeG) as enriched environments (EE), which promotes cognitive simulation with physical activity in a positive emotional context, has been proposed to represent a powerful method to slow down the decline due to @entity179 ( @entity179 ), such as @entity195 ( @entity195 ). However, so far, no SeG targeting EE has been tested in @entity179 subjects. OBJECTIVE: This study aimed at evaluating the usability and short-term training effects of X-Torp, an action SeG designed for elderly @entity179 subjects with @entity73 ( @entity73 ) and @entity195 . METHODS: X-Torp is a SeG played using the Microsoft   Kinect   . 10 @entity179 subjects and 8 healthy elderly controls (HEC) were enrolled in a 1-month program with three training sessions per week. Usability was evaluated through game time, game performance, the aerobic intensity level reached, perceived emotions, and perceived usability. RESULTS: All @entity1 successfully completed the training program. @entity179 subjects played less and had a lower game performance compared to HEC. During the sessions, @entity179 subjects maintained a light intensity of aerobic activity, while HEC maintained a moderate intensity. Both groups experienced only positive emotions, and reported a 'moderate' to 'high' perceived competence, a 'moderate' game difficulty, and a 'high' interest in the game. CONCLUSION: Usability results suggest that X-Torp represents a usable EE for healthy subjects and @entity1 with @entity73 and @entity195 . However, in order to reach moderate or high intensity of aerobic activity, X-Torp control modes should be adapted to become more physically stimulating.

title: Physical and Cognitive Stimulation Using an Exergame in Subjects with Normal Aging, Mild and Moderate XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'persons']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['ND', 'neurodegenerative diseases']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity73 :: (MESH:D003072,Disease) :: ['Cognitive Impairment']


abstract: BACKGROUND: Oxidant stress is implicated in the pathogenesis of @entity731 in @entity65 . Our aim was to test oxidative stress, as @entity7707 ( @entity7707 ), and its relationship with @entity32 markers C-reactive protein (CRP) and @entity5 necrosis factor-alpha ( @entity310 ), and endothelial activation assayed as soluble intercellular adhesion molecule (ICAM)-1 and @entity4725 in essential @entity101 . METHODS: In 216 essential @entity101 @entity1 and 55 healthy control individuals, plasma levels of high-sensitivity CRP and @entity310 , @entity7707 , @entity2071 and @entity4725 were measured in basal conditions. Moreover, basal and 24-h ambulatory blood pressure monitoring measurements were obtained. RESULTS: Essential @entity101 @entity1 showed higher levels of @entity7707 (P < 0.0001), high-sensitivity CRP, @entity310 , @entity2071 and @entity4725 (P < 0.001, respectively) than control individuals. In control individuals, @entity7707 correlated only with high-sensitivity CRP (P < 0.001). In essential @entity101 @entity1 , @entity7707 correlated with high-sensitivity CRP (P < 0.000001), @entity310 (P < 0.0001), @entity2071 (P < 0.000001), @entity4725 (P < 0.0001) and blood pressure. The multiple regression analysis considering @entity7707 as the dependent variable showed that in essential @entity101 @entity1 the independent predictors of @entity7707 were @entity2071 , high-sensitivity CRP (P < 0.00001, respectively), and @entity310 (P = 0.028). CONCLUSION: Our findings demonstrate that oxidant stress is increased in essential @entity101 , and relates to @entity32 and endothelial activation. Factors other than blood pressure are stronger predictors of oxidant stress.

title: C-reactive protein and intercellular adhesion molecule-1 are stronger predictors of oxidant stress than blood pressure in established XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-iso-PGF2alpha', '8-iso-prostaglandin F2alpha']

entities_list: @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule (VCAM)-1', 'VCAM-1']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: HYPOTHESIS: Intraoperative cell salvage (CS) of shed blood during emergency surgical procedures provides an effective and cost-efficient resuscitation alternative to allogeneic blood transfusion, which is associated with increased morbidity and mortality in @entity130 @entity1 . DESIGN: Retrospective matched cohort study. SETTING: Level I @entity130 center. @entity1 : All adult @entity130 @entity1 who underwent an emergency operation and received CS as part of their intraoperative resuscitation. The CS group was matched to a no-CS group for age, sex, Injury Severity Score, mechanism of injury, and operation performed. MAIN OUTCOME MEASURES: Amount and cost of allogeneic transfusion of packed red blood cells and plasma. RESULTS: The 47 @entity1 in the CS group were similar to the 47 in the no-CS group for all matched variables. @entity1 in the CS group received an average of 819 mL of autologous CS blood. The CS group received fewer intraoperative (2 vs 4 U; P = .002) and total (4 vs 8 U; P < .001) units of allogeneic packed red blood cells. The CS group also received fewer total units of plasma (3 vs 5 U; P = .03). The cost of blood product transfusion (including the total cost of CS) was less in the CS group ( 1616 vs  2584 per @entity1 ; P = .004). CONCLUSION: Intraoperative CS provides an effective and cost-efficient resuscitation strategy as an alternative to allogeneic blood transfusion in @entity130 @entity1 undergoing emergency operative procedures.

title: Autologous blood transfusion during emergency XXXX operations.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: BACKGROUND: Clinician adherence to @entity28 screening guidelines from United States health agencies remains suboptimal. This study explored how personal and career demographics influence pediatricians' weight assessment and management practices. METHODS: A web-based survey was distributed to U.S. pediatricians. Respondents were asked to identify the weight status of photographed @entity1 and about their weight assessment and management practices. Associations between career and personal demographic variables and pediatricians' weight perceptions, weight assessment and management practices were evaluated using univariate and multivariate modeling. RESULTS: 3,633 pediatric medical providers correctly identified the weight status of @entity1 at a median rate of 58%. The majority of pediatric clinicians were white, female, and of normal weight status with more than 10 years clinical experience. Experienced pediatric medical providers were less likely than younger colleagues to correctly identify the weight status of pictured @entity1 and were also less likely to know and use BMI criteria for assessing weight status. General pediatricians were more likely than subspecialty practitioners to provide diverse interventions for weight management. Non-white and @entity6191 were more likely than counterparts to consider cultural approaches to weight management. CONCLUSION: Pediatricians' perceptions of @entity1 's weight and their weight assessment and management practices are influenced by career and personal characteristics. Objective criteria and clinical guidelines should be uniformly applied by pediatricians to screen for and manage @entity4806 .

title: Pediatricians' weight assessment and XXXX management practices.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity6191 :: ('MESH:D004829', 'Disease') :: ['Hispanic general practitioners']

entities_list: @entity4806 :: ('MESH:D063766', 'Disease') :: ['pediatric obesity']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: @entity463 ( @entity463 ) is distinguished by a high degree of intratumoral heterogeneity, which extends to the pattern of expression and amplification of receptor @entity669 kinases (RTKs). Although most GBMs harbor RTK amplifications, clinical trials of small-molecule inhibitors targeting individual RTKs have been disappointing to date. Activation of multiple RTKs within individual GBMs provides a theoretical mechanism of resistance; however, the spectrum of functional RTK dependence among @entity5 cell subpopulations in @entity5 is unknown. We investigated the pattern of heterogeneity of RTK amplification and functional RTK dependence in @entity5 cell subpopulations. Analysis of The Cancer Genome @entity463 dataset identified 34 of 463 cases showing independent focal amplification of two or more RTKs, most commonly @entity675 ( @entity675 ) and @entity470 ( @entity470 ). Dual-color fluorescence in situ hybridization was performed on eight samples with @entity470 and @entity675 amplification, revealing distinct @entity5 cell subpopulations amplified for only one RTK; in all cases these predominated over cells amplified for both. Cell lines derived from coamplified @entity5 exhibited genotype selection under RTK-targeted ligand stimulation or pharmacologic inhibition in vitro. Simultaneous inhibition of both @entity470 and @entity3820 was necessary for abrogation of PI3 kinase pathway activity in the mixed population. DNA sequencing of isolated subpopulations establishes a common clonal origin consistent with late or ongoing divergence of RTK genotype. This phenomenon is especially common among @entity5 with @entity675 amplification: overall, 43% of @entity675 -amplified @entity463 were found to have amplification of @entity470 or the hepatocyte growth factor receptor gene (MET) as well.

title: Intratumoral heterogeneity of receptor XXXX kinases @entity470 and @entity675 amplification in @entity463 defines subpopulations with distinct growth factor response.

entities_list: @entity675 :: ('5156', 'Gene') :: ['PDGFRA', 'platelet-derived growth factor receptor a']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'GBM tumor', 'actual tumors', 'tumors']

entities_list: @entity470 :: ('1956', 'Gene') :: ['epidermal growth factor receptor', 'EGFR']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['Atlas GBM', 'GBM', 'Glioblastoma']

answer: @entity669 :: (CHEBI:18186,Chemical) :: ['tyrosine']


abstract: The aim of the study was to verify the effects of the administration of an inhibitor of the release of endogenous vasodilators together with a vasoconstrictor agent in @entity1 with @entity3182 ( @entity3182 ). This new medical perspective was compared with a traditional medical approach for @entity3182 , such as the infusion of nonpressor doses of @entity935 to produce @entity8 . Thirteen @entity1 with type 1 @entity3182 were enrolled in the study. Five of them were treated with the oral administration of @entity21172 and the parenteral administration of @entity2390 . In addition, the @entity1 received 50 to 100 mL of 20% @entity1 albumin solution daily for 20 days. @entity21172 and @entity2390 were dosed to obtain a stable increase of at least 15 mm Hg of mean arterial pressure. Eight @entity1 were treated with the intravenous administration of nonpressor doses of @entity935 (2-4 micrograms/kg/min) and the same daily amount of albumin. After 20 days of treatment with @entity21172 and @entity2390 , an impressive improvement in renal plasma flow (RPF), glomerular filtration rate, and urinary @entity1372 excretion was observed in @entity1 . This was accompanied by a significant reduction in plasma @entity916 activity, plasma vasopressin, and plasma glucagon. No side effects were observed. Three @entity1 were discharged from the hospital. One of them successfully underwent liver transplantation. One of the two remaining @entity1 is still alive after 472 days with a preserved renal function, and the other died from @entity1578 after 76 days. One of the two @entity1 who were not discharged from the hospital successfully underwent liver transplantation, and the other died from @entity55 after 29 days. Seven out of eight @entity1 who were treated with @entity935 experienced a progressive deterioration in renal function and died during the first 12 days. Only one @entity1 recovered renal function and underwent liver transplantation. In conclusion, the long-term administration of @entity21172 and @entity2390 seems to be an effective and safe treatment of type 1 @entity3182 in @entity1 with @entity82 .

title: XXXX with the administration of @entity21172 and @entity2390 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal vasodilation']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity3182 :: ('MESH:D006530', 'Disease') :: ['HRS', 'hepatorenal syndrome']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity21172 :: ('MESH:D008879', 'Chemical') :: ['midodrine', 'Midodrine']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['terminal liver failure']

entities_list: @entity2390 :: ('MESH:D015282', 'Chemical') :: ['octreotide']

answer: @entity3182 :: (MESH:D006530,Disease) :: ['Reversal of type 1 hepatorenal syndrome']


abstract: BACKGROUND: Endoscopic injection of @entity7548 is the preferred method to treat @entity2312 (GVB). However, its rebleeding rate remains high. OBJECTIVE: To compare an injection containing 0.5 mL of @entity3080 (group A) with an injection containing 1.0 mL of @entity3080 (group B). DESIGN: A single-center, randomized, controlled trial. SETTING: A tertiary referral center. MAIN OUTCOME MEASUREMENT: Occurrence of rebleeding. @entity1 : @entity1 with @entity2312 . RESULTS: Forty-four @entity1 in group A and 47 @entity1 in group B were studied; their clinical characteristics were similar. The treatment stopped active bleeding in approximately 90% of cases in both groups. The rebleeding rate was 29.8% (14/47) in group B compared with 38.6% (17/44) in group A (P = .504; 95% CI, -10.592 to 28.280). On multivariate analysis, concomitant @entity157 , @entity281 , and the size of the gastric varices were independent determinants of rebleeding. More @entity1 in group B than in group A had postinjection fever (>37.5 degrees C) (23/47 vs 12/44, P = .059). Treatment failure, complications, 30-day mortality, and survival did not differ between the 2 groups. CONCLUSIONS: Due to the small number of study @entity1 , a double dose of @entity3080 injection for GVB cannot be proven to have better hemostatic efficacy than a single dose. Multicenter studies with larger @entity1 numbers are necessary to determine whether a double dose is in fact more efficacious.

title: A randomized trial of endoscopic XXXX injection for @entity2312 : 0.5 mL versus 1.0 mL.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity3080 :: ('MESH:D003487', 'Chemical') :: ['cyanoacrylate']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity7548 :: ('MESH:D004659', 'Chemical') :: ['N-butyl-2-cyanoacrylate']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity2312 :: ('MESH:D004932', 'Disease') :: ['acute gastric variceal bleeding']

answer: @entity3080 :: (MESH:D003487,Chemical) :: ['cyanoacrylate']


abstract: Tissue damage or pathological alterations are not detectable in the majority of @entity1 with @entity74 ( @entity74 ). @entity1118 , morphological muscle changes and @entity458 are common features of @entity74 . However little is known about the presence of @entity32 and its association with symptom persistence or the clinical presentation of @entity74 . This study aimed to prospectively investigate changes in serum inflammatory biomarker levels from the acute (<3 weeks) to chronic (>3 months) stages of @entity7125 . It also aimed to determine relationships between biomarker levels and @entity1931 , fatty muscle infiltrates of the cervical extensors identified on MRI and psychological factors. 40 volunteers with acute @entity74 and 18 healthy controls participated. @entity1 with @entity74 were classified at 3 months as recovered/mild disability or having moderate/severe disability using the Neck Disability Index. At baseline both @entity74 groups showed elevated serum levels of CRP but by 3 months levels remained elevated only in the moderate/severe group. The recovered/mild disability @entity74 group had higher levels of @entity310 at both time points than both the moderate/severe @entity74 group and healthy controls. There were no differences found in serum @entity1356 . Moderate relationships were found between @entity1931 and CRP at both time points and between @entity1931 and @entity1356 3 months post injury. There was a moderate negative correlation between @entity310 and amount of fatty muscle infiltrate and @entity158 intensity at 3 months. Only a weak relationship was found between CRP and @entity158 catastrophising and no relationship between biomarker levels and posttraumatic stress symptoms. The results of the study indicate that inflammatory biomarkers may play a role in outcomes following @entity7125 as well as being associated with @entity1931 and fatty muscle infiltrate in the cervical extensors.

title: The course of serum inflammatory biomarkers following XXXX and their relationship to sensory and muscle measures: a longitudinal cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'people']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity7125 :: ('MESH:D014911', 'Disease') :: ['whiplash injury']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['WAD', 'whiplash associated disorders']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['Widespread hyperalgisa']

answer: @entity7125 :: (MESH:D014911,Disease) :: ['whiplash injury']


abstract: The objective of this study was to define the maximally tolerated dose (MTD) and response rate of a combination of two topoisomerase I inhibitors, topotecan and @entity2600 , in @entity1 with metastatic @entity694 . Eleven @entity1 , the majority with previously progressive disease on @entity1487 -based regimens, were enrolled onto a phase I/II dose escalation trial utilizing continuous infusion topotecan for 2 weeks and weekly @entity2600 x 3 with cycles repeated every 28 days. Dosages of topotecan utilized included 0.2 and 0.25mg/m2/day. @entity2600 was administered at a dose of 62 mg/m2 by i.v. bolus. @entity1 were followed for @entity137 and response. The MTD of the combination of agents was found to be 0.25mg/m2/day for @entity1945 and 62 mg/m2 for @entity2600 . The most common serious @entity137 were @entity294 and @entity390 / @entity391 . Only one @entity1 experienced @entity1398 . There were no complete or partial responses. However, four @entity1 had @entity1162 stabilization (SD) of up to 324 days and this group remained on protocol therapy for an average of 227 days (p=0.0005 versus @entity1 not achieving SD). We concluded that the MTD for this combination of topoisomerase I inhibitors, given on this particular schedule, has been defined. This combination cannot be recommended as a first- or second-line therapy for @entity1 with metastatic @entity694 based on the responses observed. However, approximately one-third of @entity1 achieved @entity1162 stabilization. Topotecan with @entity2600 may be useful as a palliative regimen for a subgroup of @entity694 @entity1 .

title: Combined topoisomerase I inhibition for the treatment of metastatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['Irinotecan', 'irinotecan']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['grade III neutropenia']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged disease']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: RATIONALE: Macrophages reside in the healthy myocardium, participate in @entity741 , and modulate @entity583 ( @entity583 ) healing. Their origin and roles in post- @entity583 remodeling of nonischemic remote myocardium, however, remain unclear. OBJECTIVE: This study investigated the number, origin, phenotype, and function of remote cardiac macrophages residing in the nonischemic myocardium in @entity19 with chronic @entity712 after coronary ligation. METHODS AND RESULTS: Eight weeks post @entity583 , fate mapping and flow cytometry revealed that a 2.9-fold increase in remote macrophages results from both increased local macrophage proliferation and monocyte recruitment. @entity712 produced by extensive @entity583 , through activation of the sympathetic nervous system, expanded medullary and extramedullary hematopoiesis. Circulating @entity19347 (high) monocytes rose from 64  5 to 108  9 per microliter of blood (P<0.05). Cardiac monocyte recruitment declined in @entity13766 (-/-) @entity19 , reducing macrophage numbers in the failing myocardium. Mechanical strain of primary @entity19 and @entity1 macrophage cultures promoted cell cycle entry, suggesting that the increased wall tension in @entity583 stimulates local macrophage proliferation. Strained cells activated the mitogen-activated protein kinase pathway, whereas specific inhibitors of this pathway reduced macrophage proliferation in strained cell cultures and in the failing myocardium (P<0.05). Steady-state cardiac macrophages, monocyte-derived macrophages, and locally sourced macrophages isolated from failing myocardium expressed different genes in a pattern distinct from the M1/M2 macrophage polarization paradigm. In vivo silencing of endothelial cell adhesion molecules curbed post- @entity583 monocyte recruitment to the remote myocardium and preserved ejection fraction (27.4  2.4 versus 19.1  2%; P<0.05). CONCLUSIONS: @entity712 is influenced by an altered myeloid cell repertoire.

title: Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in XXXX .

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Myocardial failure', 'Heart failure', 'heart failure']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['post-MI heart failure', 'myocardial infarction', 'MI']

answer: @entity712 :: (MESH:D006333,Disease) :: ['Chronic Heart Failure']


abstract: PURPOSE: Recent studies suggest that @entity1 <24 months with stage I favorable histology @entity3969 <550 g [very low risk @entity3969 (VLRWT)] have an excellent prognosis when treated with nephrectomy only, without adjuvant chemotherapy. The identification of risk categories within VLRWT may enable refinement of their definition and optimization of their therapy. EXPERIMENTAL DESIGN: To define biologically distinct subsets, global gene expression analysis was done on 39 VLRWT that passed all quality-control parameters and the clusters identified were validated in an independent set of 11 VLRWT. Validation of select differentially expressed genes was done with immunohistochemistry on a tissue microarray from 20 of 39 @entity5 . Loss of heterozygosity (LOH) for 11p15, 1p, and 16q was analyzed in 52 @entity5 using PCR. RESULTS: Two distinctive clusters were identified. One cluster included 9 @entity5 with epithelial differentiated tubular histology, paucity of @entity3040 rests, lack of LOH for 1p, 16q, and 11p, absence of relapse, and a unique gene expression profile consistent with @entity1167 following mesenchymal-to-epithelial transition. The second cluster included 13 @entity5 with mixed histology, intralobar @entity3040 rests, and decreased expression of @entity8587 . Three of 6 relapses occurred in this cluster. Of 43 informative @entity5 , 11p LOH was present in 5 of 5 relapses and 11 of 38 nonrelapses. CONCLUSIONS: Two subsets comprising a total of 56% of VLRWT are identified that have pathogenetic and molecular differences and apparent differences in risk for relapse. If these predictors can be prospectively validated, this would enable the refinement of clinical stratification and less arbitrary definition of VLRWT.

title: Subsets of very low risk XXXX show distinctive gene expression, histologic, and clinical features.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumors']

entities_list: @entity3040 :: ('MESH:D018500', 'Disease') :: ['nephrogenic']

answer: @entity3969 :: (MESH:D009396,Disease) :: ['Wilms tumor']


abstract: PURPOSE: To identify prognostic factors that determine visual outcome following phacoemulsification @entity231 surgery complicated by @entity393 . METHODS: A retrospective cohort study. All cases of @entity393 during phacoemulsification surgery at a university hospital, between June 2000 and December 2005, were identified from the hospital computer database. By reviewing the medical notes, preoperative, intraoperative, and postoperative data were collected. Outcome of interest was presence of poor visual outcome (best-corrected visual acuity [BCVA] <6/12). Chi-square and Mann-Whitney U tests were used to compare groups of poor and good visual outcome. RESULTS: A total of 230 consecutive cases (eyes) were identified; medical notes were available for 228. Mean @entity1 age was 78.4 years (SD 11); median follow-up 13.4 weeks (range 1-203). In multivariable logistic regression analysis poor visual outcome was independently associated with poor preoperative vision (BCVA <6/12) (OR 3.78, 95% CI 1.76-8.11), age-related @entity1020 (OR 3.04, 95% CI 1.16-8.00), @entity1103 (OR 3.85, 95% CI 1.29-11.51), and secondary pars plana vitrectomy ( @entity2286 ) for nuclear fragment loss (OR 4.42, 95% CI 1.03-19.02). Primary @entity2286 for nuclear fragment loss, age >70, ocular comorbidity, axial length, @entity393 during irrigation/aspiration, or lens implantation, anterior chamber lens, and secondary lens implantation were not significant associations (p>or= 0.05). In 33 (14.5%) eyes BCVA was reduced by at least one Snellen line compared to before surgery. CONCLUSIONS: Poor visual outcome was associated with poor preoperative vision, age-related @entity1020 , @entity1103 , and secondary @entity2286 following nuclear fragment loss. Primary @entity2286 for nuclear fragment loss was not a significant association.

title: Prognostic factors that determine visual outcome following @entity231 surgery complicated by XXXX .

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['cystoid macular edema']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['vitreous loss']

answer: @entity393 :: (MESH:D034381,Disease) :: ['vitreous loss']


abstract: UNASSIGNED: Introduction   @entity65 ( @entity65 ) is the leading cause of @entity204 in post menopausal @entity1 , and @entity32 is involved in the @entity731 process. Purpose   to assess whether dietary pattern, metabolic profile, body composition and physical activity are associated with low-grade chronic @entity32 according to high-sensitivity C-reactive protein (hs-CRP) levels in postmenopausal @entity1 . Methods   ninety-five postmenopausal @entity1 , with no evidence of clinical disease, underwent anthropometric, metabolic and hormonal assessments. Usual dietary intake was assessed with a validated food frequency questionnaire, habitual physical activity was measured with a digital pedometer, and body composition was estimated by bioelectrical impedance analysis. @entity1 with hs-CRP   >= 10 mg/L or using hormone therapy in the last three months before the study were excluded from the analysis. @entity1 were stratified according to hs-CRP lower or   >= 3 mg/L. Sedentary lifestyle was defined as walking fewer than 6 thousand steps a day. Two-tailed Student's t-test, Wilcoxon-Mann-Whitney U or Chi-square (  (2)) test were used to compare differences between groups. A logistic regression model was used to estimate the odds ratio of variables for high hs-CRP. Results   @entity1 with hs-CRP   >= 3 mg/L had higher body mass index (BMI), body fat percentage, waist circumference (WC), @entity1674 , @entity413 , and homeostasis model assessment of insulin resistance (HOMA-IR) (p   =   0.01 for all variables) than @entity1 with hs- @entity29726 mg/L. Also, @entity1 with hs-CRP   >= 3 mg/L had a higher glycemic load diet and lower protein intake. Prevalence of sedentary lifestyle (p   <   0.01) and @entity209 (p   <   0.01) was higher in @entity1 with hs-CRP   >= 3 mg/L. After adjustment for age and time since menopause, the odds ratio for hs-CRP   >= 3 mg/L was higher for sedentary lifestyle (4.7, 95% confidence interval [95%CI] 1.4-15.5) and @entity1735 intake (2.9, 95%CI 1.1-7.7). Conclusions   sedentary lifestyle and high- @entity1735 intake were associated with low-grade chronic @entity32 and cardiovascular risk in postmenopause.

title: Sedentary Lifestyle and High- XXXX Intake are Associated with @entity32 in Post-Menopause: A Cross-sectional Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patients', 'Participants']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular disease', 'CVD']

answer: @entity1735 :: (CHEBI:16646,Chemical) :: ['Carbohydrate']


abstract: PURPOSE: To describe the histopathological distribution of biopsied @entity75 in a tertiary referral centre in Singapore. METHODS: This was a retrospective chart review. Clinical records of @entity1 who underwent lacrimal gland biopsy at a tertiary referral centre in Singapore between 2000 to 2010, were reviewed. Data collated included @entity1 demographics, clinical presentation, association with @entity262 and histopathological diagnosis. RESULTS: Sixty-nine @entity1 were studied. Median age of presentation was 50 years. Forty @entity1 (58%) were female and the majority (84%, n = 29) were Chinese. The mean follow-up duration was 35.0    34.5 months. 30.4% (n = 21) of the @entity1 had bilateral disease. @entity4578 (46%, n = 32) was the most common histopathological diagnosis, followed by @entity1071 (38%, n = 26) and @entity5123 (10%, n = 7). The diagnoses in four other @entity1 included @entity2347 , lacrimal gland @entity1184 , lacrimal duct cyst and @entity2694 . CONCLUSION: @entity4578 and @entity1071 are the two commonest causes of @entity75 in our series. Although many cases remain non-specific, about 60% have a specific @entity32 that may be associated with a @entity262 . As one third of our @entity1 with @entity1071 of the lacrimal gland had an associated @entity706 , @entity1 with such lesions should be referred for investigation of possible @entity706 . The results of our study can aid in providing a more targeted approach to @entity1 management.

title: A survey of the histopathology of XXXX in a tertiary referral centre.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1071 :: ('MESH:D008232', 'Disease') :: ['lymphoproliferative disorders', 'lymphoproliferative disease']

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['pleomorphic adenoma']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['systemic lymphoma']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['lacrimal gland lesions']

entities_list: @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity2694 :: ('MESH:D009916', 'Disease') :: ['orbital vascular malformation']

entities_list: @entity4578 :: ('MESH:D003607', 'Disease') :: ['Chronic dacryoadenitis']

answer: @entity75 :: (MESH:D001927,Disease) :: ['lacrimal gland lesions']


abstract: BACKGROUND: The management of high-grade @entity99 often involves a combination of operative and nonoperative strategies. Angioembolization (AE) is frequently used in the management of these @entity130 . Morbidity in @entity1 with high-grade @entity99 remains high despite improvements in mortality with a multimodality approach. @entity99 ( @entity99 ) is a morbid, but underappreciated complication of AE in this @entity1 population. This study will examine the risk factors and outcomes of @entity1 with high-grade liver injures managed with AE who developed the complication of @entity99 . METHODS: @entity1 admitted to the R Adams Cowley Shock @entity130 Center between January 2002 and December 2007 with high-grade blunt or penetrating @entity99 (grades III-VI) were identified from the @entity130 registry and the medical records were retrospectively reviewed. @entity130 specific data, complications, and admission physiologic variables were collected. @entity1 who had therapeutic AE, either preoperatively or postoperatively, and went on to develop @entity409 including @entity99 were reviewed. RESULTS: There were 538 @entity1 with high-grade @entity99 admitted during a 5-year period. One hundred and sixteen @entity1 (22%) underwent angiography, and 71 (13%) had a therapeutic AE. Sixteen @entity1 (22.5%) had grade III @entity130 , 44 (62%) had grade IV @entity130 , and 11 (15.5%) had grade V @entity130 . Overall mortality in this group was 14% with eight @entity1 (11.3%) dying as a result of their @entity99 . Complication rates were 18.8%, 65.9%, and 100% in the @entity1 with grades III, IV, and V @entity130 , respectively, for an overall complication rate of 60.6%. Thirty @entity1 (42.2%) went on to develop @entity99 . @entity1 who developed @entity99 were compared with those who did not. Baseline characteristics, Injury Severity Score, and hemodynamic parameters at admission were no different between the two groups. @entity1 with @entity99 had higher grade @entity130 , required significantly more blood product transfusions, and had a significantly longer length of stay (all p < 0.001). @entity1 who developed @entity99 were more likely to have undergone operative intervention (96.7% vs. 41.5%, p < 0.001), with 87% having a damage control laparotomy. Other @entity409 occurred more frequently in the @entity1 that developed @entity99 (60.0% vs. 34.1%, p = 0.03). However, mortality was not different in the two groups. CONCLUSION: High-grade @entity99 pose significant challenges to those who care for @entity130 @entity1 . Many @entity1 can be successfully managed nonoperatively, but there are still @entity1 that require laparotomy. AE is the logical augmentation of damage control techniques for controlling @entity548 . However, given the nature and severity of these @entity130 , these therapies are not without complications. @entity99 was found to be a common complication in our study. It tended to occur in high-grade injures, was associated with higher complication rates, longer hospital length of stay, and higher transfusion requirements. Management of @entity99 can be challenging. Factors that still need to be elucidated are the role of perihepatic packing and timing of second look operation.

title: @entity99 : a common complication after angioembolization for treatment of high-grade XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver-related complications']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['Major hepatic necrosis', 'liver injuries', 'MHN', 'hepatic injuries', 'liver injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'Trauma', 'trauma', 'Demographic and injury']

answer: @entity99 :: (MESH:D056486,Disease) :: ['liver injuries']


abstract: Water deficit or @entity2700 is the most crucial environmental constraint on plant growth and development and crop productivity. It has been postulated that plants respond and adapt to @entity2700 by altering their cellular metabolism and by activating various defense machineries. The nucleus, the regulatory hub of the eukaryotic cell, is a dynamic system and a repository of various macromolecules that serve as modulators of cell signaling dictating the cell fate decision. To better understand the molecular mechanisms of @entity2700 -responsive adaptation in plants, we developed a comprehensive nuclear proteome of @entity579 . The proteome was determined using a sequential method of organellar enrichment followed by two-dimensional electrophoresis-based protein identification by LC-ESI-MS/MS. We initially screened several commercial @entity579 varieties and parental lines and established their relative @entity2700 tolerance. The differential display of nuclear proteins in the tolerant variety under study revealed 150 spots that showed changes in their intensities by more than 2.5-fold. The proteomics analysis led to the identification of 109 differentially regulated proteins presumably involved in a variety of functions, including transcriptional regulation and chromatin remodeling, signaling and gene regulation, cell defense and rescue, and protein degradation. The @entity2700 -responsive nuclear proteome revealed a coordinated response involving both regulatory and functional proteins, impinging upon the molecular mechanism of @entity2700 adaptation. Furthermore a comparison between the @entity2700 -responsive nuclear proteome of @entity579 and that of a legume, the @entity13474 , showed an evolutionary divergence in @entity2700 response comprising a few conserved proteins, whereas most of the proteins may be involved in crop-specific adaptation. These results might help in understanding the spectrum of nuclear proteins and the biological processes they control under @entity2700 as well as having implications for strategies to improve @entity2700 tolerance in plants.

title: Dehydration-responsive nuclear proteome of XXXX ( @entity579 .) illustrates protein network, novel regulators of cellular adaptation, and evolutionary perspective.

entities_list: @entity2700 :: ('MESH:D003681', 'Disease') :: ['dehydration']

answer: @entity579 :: (4530,Species) :: ['rice']


abstract: BACKGROUND: Cervical approaches to the dens are limited by the presence of several structures, including the spinal cord, the vertebral arteries, the C1 @entity1605 . Surgical approaches to access the high anterior cervical spine classically encompass the extended anterior retropharyngeal route, transoral route, and extreme lateral route, each of which has its own pattern of morbidity or complications. Percutaneous procedures to drain @entity281 in this area have a limited yield. @entity4034 of the dens is a rare but serious condition that is associated with significant mortality. @entity1 with cervical @entity4034 and @entity7181 are likely to have significant coexistent medical comorbidities and are often poor candidates for extensive surgical procedures. A minimally invasive approach that gives access to the entire odontoid process would allow for more aggressive treatments and potentially even a complete odontoidectomy without resection of the C1 anterior arch. CASE DESCRIPTION: We describe a minimally invasive approach to drainage and debridement of an @entity7181 and @entity4034 . Using minimally invasive techniques from a posterolateral trajectory in a cadaveric specimen, we were able to safely access the anterior epidural space, odontoid, and retropharynx. We then performed this approach in our @entity1 who was unable to tolerate a large surgical procedure. CONCLUSION: We developed, tested, and then applied a minimally invasive approach that combined tubular retractors with positioning of the head and neck to optimize the exposure in a @entity1 with a complex abscess that involved the ventral epidural space, the odontoid process, and the retropharyngeal space. The abscesses were successfully drained along with local tissue debridement without complication. A posterolateral minimally invasive approach is a safe alternative in @entity1 with an @entity9807 , odontoid @entity4034 , or retropharyngeal abscess with significant medical comorbidities who are unlikely to tolerate a more extensive surgery. It can also be used for resections of lesions of an oncological nature, and could even be used to resect @entity2070 or os odontoideum, without necessitating an anterior approach or resection even of the C1 arch.

title: Minimally Invasive Surgical Approach for Odontoid Lesions: A Technical Description in a case of High Cervical XXXX and Abscess.

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['articular pillars, and the C2 nerves']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['Osteomyelitis', 'osteomyelitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity7181 :: ('MESH:D020802', 'Disease') :: ['epidural abscess', 'atlantoaxial epidural abscess']

entities_list: @entity9807 :: ('MESH:C538196', 'Disease') :: ['atlanto-axial epidural abscess']

answer: @entity4034 :: (MESH:D010019,Disease) :: ['Osteomyelitis']


abstract: The recently described @entity4016 @entity4017 mutation, present in a substantial proportion of nonchronic @entity2800 chronic @entity6961 ( @entity1860 ), is changing the way we conceptualize and diagnose these diseases. We hypothesized that the activation of this @entity669 kinase might result in activation of downstream mediators such as @entity11715 , which would be detectable in bone marrow biopsies. We examined the expression of activated @entity11715 (nuclear phospho- @entity11715 ) in 73 bone marrow biopsies from @entity1 with CMPDs [20 essential @entity1148 (ET), 26 @entity4018 ( @entity4018 ), and 27 @entity6582 vera] and 39 controls. We compared the results with the @entity4016 mutational status and clinical parameters. The frequency of the @entity4016 @entity4017 was 73% (85% in PV, 65% in ET, and 65% in @entity4018 ). All @entity1 with the @entity4016 @entity4017 showed abnormal nuclear megakaryocytic phospho- @entity11715 (nMEG pSTAT5) expression. In the @entity4016 wild-type group, nMEG pSTAT5 was observed in 2/7 ET, and 3/9 @entity4018 @entity1 . nMEG pSTAT5 staining was 100% sensitive and 88% specific for @entity4016 @entity4017 . Clinically, nMEG pSTAT5+ @entity1 seemed to require cytoreductive therapy more often than those without nMEG p-STAT expression. pSTAT5 immunohistochemistry is a useful diagnostic test in bone marrow biopsies from suspected non-CML @entity32942 @entity1 . It identifies most of the @entity1 with the @entity4016 @entity4017 but also other @entity4016 wild-type @entity32942 @entity1 . The presence of nMEG pSTAT5 in a subset of @entity32942 @entity1 lacking the mutation suggests that alternate @entity669 kinase/phosphatase pathways may be involved and warrant further investigation. Phosphoprotein detection represents a new area for diagnostic pathology that exploits specific functional characteristics of cells within the context of a tissue section.

title: Bone marrow phospho- XXXX expression in non-CML chronic @entity6961 correlates with @entity4016 @entity4017 mutation and provides evidence of in vivo @entity4016 activation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocythemia']

entities_list: @entity2800 :: ('MESH:D007951', 'Disease') :: ['myelogenous leukemia']

entities_list: @entity4018 :: ('MESH:D055728', 'Disease') :: ['CIMF', 'chronic idiopathic myelofibrosis']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['non-CML CMPDs']

entities_list: @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorders']

answer: @entity11715 :: (6776,Gene) :: ['STAT5']


abstract: The aim of this study was to critically analyze the effects of @entity273 on growth and survival of bacterial cells in order to prove or disprove its purported role as a main component responsible for the antibacterial activity of honey. Using the sensitive @entity2625 /peroxidase assay, broth microdilution assay and DNA degradation assays, the quantitative relationships between the content of @entity274 and honey's antibacterial activity was established(.) The results showed that: (A) the average @entity274 content in honey was over 900-fold lower than that observed in disinfectants that kills bacteria on contact. (B) A supplementation of bacterial cultures with @entity274 inhibited @entity526 and @entity3881 growth in a concentration-dependent manner, with minimal inhibitory concentrations (MIC(90)) values of 1.25   mM/10(7)   cfu/ml and 2.5   mM/10(7)   cfu/ml for @entity526 and @entity3881 , respectively. In contrast, the MIC(90) of honey against @entity526 correlated with honey @entity274 content of 2.5   mM, and growth inhibition of @entity3881 by honey did not correlate with honey @entity274 levels at all. (C) A supplementation of bacterial cultures with @entity274 caused a concentration-dependent degradation of bacterial DNA, with the minimum DNA degrading concentration occurring at 2.5   mM @entity274 . DNA degradation by honey occurred at lower than  <=2.5   mM concentration of honey @entity274 suggested an enhancing effect of other honey components. (D) Honeys with low @entity274 content were unable to cleave DNA but the addition of @entity274 restored this activity. The @entity29334 -like activity was heat-resistant but catalase-sensitive indicating that @entity274 participated in the oxidative DNA damage. We concluded that the honey @entity274 was involved in oxidative damage causing bacterial growth inhibition and DNA degradation, but these effects were modulated by other honey components.

title: Re-examining the role of XXXX in bacteriostatic and bactericidal activities of honey.

entities_list: @entity2625 :: ('CHEBI:44785', 'Chemical') :: ['peroxide']

entities_list: @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide']

answer: @entity273 :: (MESH:D006861,Chemical) :: ['hydrogen peroxide']


abstract: OBJECTIVE: To report the use of low-pressure @entity544 insufflation during video-assisted thoracoscopic surgery for resection of a @entity704 in a cat with secondary @entity1737 . STUDY DESIGN: Clinical case report. ANIMAL: Client-owned cat. METHODS: An 11-year-old castrated male domestic shorthair cat was examined for generalized weakness, @entity1740 , @entity4164 , hyporexia, @entity391 , coughing, and gagging. @entity1514 ultrasound revealed a cranial mediastinal mass for which cytology was consistent with a @entity704 (or lymphoid tissue). @entity934 receptor antibody concentration was elevated at 3.16 mmol/L (reference interval   <   0.3 mmol/L). @entity1514 computed tomography showed two round, contrast-enhancing structures in the cranioventral mediastinum identified as the sternal lymph node and a cranial mediastinal mass (11 * 17 * 24 mm). A presumptive diagnosis of @entity704 with @entity1737 was made and surgical resection of both mediastinal masses was recommended. RESULTS: Video-assisted thoracoscopic resection of the cranial mediastinal mass and sternal lymph node were performed with low-pressure @entity544 insufflation maintained at an intrathoracic pressure of 2-3 mmHg. The cat recovered from surgery without serious complications. Nineteen months after surgery, the cat developed hind limb stiffness. @entity1514 radiographs ruled out a cranial mediastinal mass or @entity1318 . @entity934 receptor antibody concentration remained elevated at 2.72 mmol/L. CONCLUSION: Low-pressure thoracic insufflation facilitated video-assisted thoracoscopic resection of cranial mediastinal masses in this cat.

title: Video-Assisted Thoracoscopic Resection of a @entity704 in a Cat with XXXX Using Low-Pressure @entity544 Insufflation.

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['megaesophagus']

entities_list: @entity704 :: ('MESH:D013945', 'Disease') :: ['noninvasive thymoma', 'thymoma']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['paraneoplastic myasthenia gravis', 'myasthenia gravis']

entities_list: @entity4164 :: ('MESH:D012798', 'Disease') :: ['hypersalivation']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']

entities_list: @entity1740 :: ('MESH:D014832', 'Disease') :: ['voice change']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['Acetylcholine']

answer: @entity1737 :: (MESH:D009157,Disease) :: ['Myasthenia Gravis']


abstract: OBJECTIVE: The aim of this study was to evaluate the effect of the @entity167 consumption on the @entity604 ( @entity604 ) in experimental @entity2521 in @entity35 . MATERIALS AND METHODS: Sixty-three male @entity35 were divided into seven groups: G1 (control); G2 (10% @entity1068 ); G3 (nutritional control of G2); G4 (20% @entity1068 ); G5 (nutritional control of G4); G6 (30% @entity1068 ) and G7 (nutritional control of G6). The groups G3, G5 and G7 received controlled diets with equivalent caloric amounts to those consumed in G2, G4 and G6 respectively, with the @entity1068 replaced by @entity969 . After anesthesia, ligatures were installed around the mandibular first molar, leaving the contralateral teeth unligated. After 8 weeks, the @entity35 were killed and their mandibles were radiographed to measure the percentage of @entity604 on the distal aspect. RESULTS: The intragroup analyses showed that presence of ligatures induced @entity2521 (p<0.05). Unligated groups did not show significant differences among the percentages of @entity604 (p=0.1969). However, in ligated groups the @entity35 that received @entity167 (G2:48.71%+/-3.88; G4:47.66%+/-2.54; G6:47.32%+/-3.24) and the nutritional control group associated with a high concentration of @entity1068 (G7:47.40%+/-3.24) presented a significantly lower percentage of @entity604 than the other groups (G1:52.40%+/-2.75; G3:52.83%+/-2.41; G5:50.85%+/-4.14). CONCLUSIONS: These results demonstrated that @entity167 consumption in @entity35 may result in a direct effect on @entity604 and increased development of @entity2521 . In addition, they suggest that heavy caloric consumption of @entity1068 may also present an indirect effect on periodontal tissue as a consequence of @entity3147 .

title: The effect of @entity167 consumption on XXXX in experimental @entity2521 in @entity35 .

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['alveolar bone loss', 'PBS', 'periodontal bone support']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

answer: @entity604 :: (MESH:D016301,Disease) :: ['periodontal bone support']


abstract: OBJECTIVE: Evaluation of @entity301 in @entity1 with @entity573 ( @entity573 ) by two-dimensional echocardiography. SETTING: Outpatient and Laboratory of Echocardiography in the Pediatric Cardiology Department of Santa Marta Hospital. @entity1 : Forty four @entity1 (M/F = 1.7/1) with a mean age of 2 years and 8 months (range from 2 months to 8 years) underwent Outpatient and serial echocardiographic study from July 1984 to December 1988. RESULTS: @entity453 were demonstrated in 13 (52%) of 44 @entity1 ; 11 (25%) had uniform dilatation and 12 (27%) had @entity439 . These anomalies were never observed before the first week of illness. During a mean follow-up of 8.4 months, we have observed normalization of coronary arteries lumen, in 10 (43.4%) of the 23 cases. The anomalies remained in 13 (56.6%). CONCLUSIONS: @entity453 are a frequent complication of @entity573 . In about 50% of @entity1 , @entity453 remained in a mean follow-up of 8 months. Two-dimensional echocardiography is a good method to study @entity301 in @entity573 .

title: [Changes in the coronary arteries in XXXX : echocardiographic aspects].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS']

entities_list: @entity573 :: ('MESH:C537014', 'Disease') :: ['KD', 'Kawasaki disease']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary anomalies']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery anomalies', 'Coronary artery anomalies']

answer: @entity573 :: (MESH:C537014,Disease) :: ['Kawasaki disease']


abstract: We used an in silico approach to predict microRNAs (miRNAs) genome-wide in the brown alga @entity26539 . As @entity3312 are phylogenetically distant from both animals and land plants, our approach relied on features shared by all known organisms, excluding sequence conservation, genome localization and pattern of base-pairing with the target. We predicted between 500 and 1500 miRNAs candidates, depending on the values of the energetic parameters used to filter the potential precursors. Using quantitative polymerase chain reaction assays, we confirmed the existence of 22 miRNAs among 72 candidates tested, and of 8 predicted precursors. In addition, we compared the expression of miRNAs and their precursors in two life cycle states (sporophyte, gametophyte) and under salt stress. Several miRNA precursors, Argonaute and DICER messenger RNAs were differentially expressed in these conditions. Finally, we analyzed the gene organization and the target functions of the predicted candidates. This showed that @entity26539 miRNA genes are, like plant miRNA genes, rarely clustered and, like animal miRNA genes, often located in introns. Among the predicted targets, several widely conserved functional domains are significantly overrepresented, like kinesin, @entity377 -binding/APAF-1, R proteins and CED-4 (NB-ARC) and tetratricopeptide repeats. The combination of computational and experimental approaches thus emphasizes the originality of molecular and cellular processes in @entity3312 .

title: Computational prediction and experimental validation of microRNAs in the brown alga XXXX .

entities_list: @entity26539 :: ('2880', 'Species') :: ['E. siliculosus', 'Ectocarpus siliculosus']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity3312 :: ('MESH:D002095', 'Disease') :: ['brown algae']

answer: @entity26539 :: (2880,Species) :: ['Ectocarpus siliculosus']


abstract: The purpose of this study was to investigate the incidence and characteristics of @entity1795 in @entity1 with @entity6 . A questionnaire about trigger digit was completed by 544 @entity1 with @entity6 . Ten percent of the @entity1 had a history of @entity1795 and 4% had multiple digit involvement. The risk was significantly higher in insulin-dependent @entity1 . The average duration of @entity6 was significantly longer in the multiple digit group. Independently, the medical records of 132 trigger digit @entity1 who underwent surgery were reviewed. Twenty-seven @entity1 had @entity6 , and 62 @entity1 had multiple digit involvement. Involvement of more than three digits was significantly related to co-existing @entity6 . In @entity1 with @entity6 , the incidence of @entity1795 was about four times higher than in the general population. Screening for @entity6 may be warranted in @entity1 with involvement of more than three digits.

title: @entity1795 in XXXX : their incidence and characteristics.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1795 :: ('MESH:D052582', 'Disease') :: ['trigger digits']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: INTRODUCTION: Emergency department length of stay ( @entity2613 LOS) is currently used in Australasia as a quality measure. In our @entity2613 , Maori, the indigenous @entity1 of New Zealand, have a shorter @entity2613 LOS than European @entity1 . This is despite Maori having poorer health outcomes overall. This study sought to determine drivers of LOS in our provincial New Zealand @entity2613 , particularly looking at ethnicity as a determining factor. METHODS: This was a retrospective cohort study that reviewed 80,714 electronic medical records of @entity2613 @entity1 from December 1, 2012, to December 1, 2014. Univariate and multivariate analyses were carried out on raw data, and we used a complex regression analysis to develop a predictive model of @entity2613 LOS. Potential covariates were @entity1 factors, temporal factors, clinical factors, and workload variables (volume and acuity of @entity1 three hours prior to and two hours after presentation by a baseline @entity1 ). The analysis was performed using R studio 0.99.467. RESULTS: Ethnicity dropped out in the stepwise regression procedure; after adjusting for other factors, a specific ethnicity effect was not informative. Maori were, on average, younger, less likely to receive bloodwork and radiographs, less likely to go to our observation area, less likely to have a general practitioner, and more likely to be discharged and to self-discharge; all of these factors decreased their length of stay. CONCLUSION: Length of stay in our @entity2613 does not seem to be related to ethnicity alone. @entity1 factors had only a small impact on @entity2613 LOS, while clinical factors, temporal factors, and workload variables had much greater influence.

title: Emergency Department Length of Stay for Maori and European XXXX in New Zealand.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'people']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: AIM: To analyse the correlation of @entity4206 expression and cell cycle kinetics of @entity1 limbal epithelial cells (HLECs) expanded on amniotic membrane (AM) or plastic. METHODS: Primary HLECs were cultured either on cryopreserved intact AM or plastic dishes for 2 weeks. Cells were labelled with 5 microM @entity1603 ( @entity1603 ) for 3 days, followed by an interval of either 7 or 14 days in @entity1603 -free medium. The expression of @entity4206 and @entity1603 labelling was detected by immunocytochemistry. RESULTS: More cells on AM (56%) than on plastic (24%) retained their @entity1603 label after the 7-day interval (p < 0.001). The difference was even more pronounced after 14 days (20 and 2%, p < 0.001). All @entity1603 -labelled cells were also @entity4206 positive. 2.5-fold more cells on AM (54%) than on plastic (21%) were @entity1603 positive/ @entity4206 positive after 7 days (p < 0.001). It increased to a 9-fold difference after 14 days (p < 0.001). The @entity1603 label was lost more quickly than the @entity4206 expression during the observation period, indicating that @entity4206 expression was not confined to stem cells but existed also in transient amplifying cells. CONCLUSIONS: The combination of @entity4206 expression and @entity1603 label retention is a better criterion to characterize @entity3308 than either marker alone. AM as a culture substrate preserves @entity3308 better than plastic.

title: Correlation of cell cycle kinetics with @entity4206 expression in @entity1 limbal epithelial cells expanded on intact XXXX amniotic membrane.

entities_list: @entity1603 :: ('MESH:D001973', 'Chemical') :: ['BrdU', "5-bromo-2'-deoxyuridine"]

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: Few comparisons of real-world insulin detemir ( @entity2471 ) and insulin glargine (GLAR) utilization have been conducted, which would assist payers and other healthcare decision makers assess the cost effectiveness of these treatment alternatives. The aim of this study was to compare the amount of insulin utilized in a large cohort of @entity1 with @entity164 2 @entity6 treated with either @entity2471 or GLAR in the real-world setting considering the use of other antidiabetic agents. RESEARCH DESIGN AND METHODS: A nested case-control study was conducted using data from a large US medical and pharmacy claims data warehouse. Adults with @entity164 2 @entity6 newly treated with @entity2471 or GLAR were included. From this overall cohort, a subset of @entity2471 @entity1 were matched 1:1 to GLAR on age, baseline antidiabetic use, and comorbidities. Descriptive statistics were used to compare @entity1 characteristics between treatment groups; a Wilcoxon rank sum test was used to compare insulin utilization in terms of the @entity1 level daily average consumption (DACON). MAIN OUTCOMES MEASURES: Mean DACON by analog basal insulin. RESULTS: This study included 18,763 @entity1 ; 2215 (11.8%) were treated with @entity2471 and 16,548 (88.2%) with GLAR. @entity2471 @entity1 were slightly younger (59.6 vs. 60.3 years; p < or = 0.01); gender did not differ (46% female). From the overall cohort, 1581 @entity2471 @entity1 were matched to 1581 GLAR @entity1 . Mean (median) DACON did not differ overall (35 [26] units for @entity2471 vs. 32 [27] units for GLAR; p = 0.06) or in the matched cohort (35 [26] units for @entity2471 vs. 32 [27] units for GLAR; p = 0.146). In the matched cohort, there were no differences in non-insulin antidiabetic use after @entity2471 or GLAR was started. CONCLUSIONS: In a real-world setting, insulin utilization did not differ between @entity2471 and GLAR controlling for @entity1 characteristics and considering concomitant antidiabetic treatments, which could influence insulin use. A limitation is that the dispensing data as used in this study may not accurately reflect daily insulin dose because @entity1 may discard unused insulin portions when the vial or pre-filled syringe reaches its in-use expiration date. Additional research is warranted to determine if there are differences in @entity2471 and GLAR utilization over time.

title: Comparison of daily insulin dose and other antidiabetic medications usage for @entity164 2 @entity6 XXXX treated with an analog basal insulin.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The purpose of this study is to evaluate the role of @entity11943 ( @entity11943 ), @entity18696 ( @entity18696 ), and their receptors in altered renal growth caused by complete @entity1695 in the developing kidney. Neonatal and adult @entity35 underwent complete unilateral ureteral ligation or sham operation. The kidneys were harvested at 1, 5, 10, 20, and 30 days after obstruction. Renal growth and development was assessed by histology and immunohistocytochemical localization of @entity7229 , cytokeratin and @entity23488 . Cellular proliferation was measured by @entity665 labeling index of all cells. RNase protection assays were used to quantify mRNA encoding for @entity11943 , @entity11943 receptor, @entity18696 , and @entity10816 . @entity1695 in the developing kidneys resulted in decreased DNA synthesis, rapid parenchymal loss, myofibroblast proliferation in the interstitium, decreased tubular epithelial cells formation, and development of @entity28004 . In comparison, obstruction in the mature kidneys resulted in transient growth in the medullary ductal cells, parenchymal loss, and myofibroblast proliferation at a later time, lymphocytic infiltration in the interstitium but not @entity28004 . @entity11943 and @entity11943 receptor mRNA levels were @entity8 . Similarly, @entity18696 and @entity10816 mRNA levels were increased. Delayed and more moderate increases in @entity11943 , @entity11943 receptor, and @entity18696 expression were also seen in the obstructed mature kidneys. Of importance, the amount of @entity10816 mRNA was not increased in the obstructed compared with the contralateral or sham-operated adult kidneys. This study suggests that obstruction alters the normal expression pattern of @entity11943 , @entity18696 , and their receptors in renal development. These changes may be responsible for the @entity8 and altered development seen in @entity8 . Although some changes are similar to those seen in the adult kidney, the increased expression of @entity18696 and @entity28004 are unique to neonatal obstruction.

title: Growth factor expression in the obstructed developing and mature XXXX kidney.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['impaired renal growth', 'increased in obstructed neonatal kidneys', 'ureteral obstruction of the kidneys']

entities_list: @entity10816 :: ('24329(Tax:10116)', 'Gene') :: ['EGF receptor', 'epidermal growth factor (EGF) receptor']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['Ureteral obstruction', 'ureteral obstruction']

entities_list: @entity11943 :: ('29348(Tax:10116)', 'Gene') :: ['keratinocyte growth factor', 'KGF']

entities_list: @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[3H]thymidine']

entities_list: @entity28004 :: ('MESH:C537755', 'Disease') :: ['cystic dysplasia']

entities_list: @entity23488 :: ('81633(Tax:10116)', 'Gene') :: ['smooth muscle-alpha actin']

entities_list: @entity18696 :: ('24827(Tax:10116)', 'Gene') :: ['transforming growth factor-alpha', 'TGF-alpha']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: The pleth variability index (PVI), which is calculated from respiratory variations in the perfusion index (PI), has been shown to predict fluid responsiveness in mechanically ventilated @entity1 ; however, vasomotor tone changes induced by @entity2944 can affect PI and hence may slim down the accuracy of PVI. This study was designed to find out the impact of mild @entity2944 on PVI. METHODS: A total of 30 @entity1 were randomized after induction of general anesthesia with target controlled infusion @entity1875 and @entity1937 to either @entity2944 , (et @entity515 =45 mmHg), (group 1, 15 @entity1 ) or normocapnia (et @entity515 =35 mmHg) (group 2, 15 @entity1 ). After a stabilization period of 10 min, @entity1 were crossed over to the other intentional level of et @entity515 . Heart rate (HR), mean arterial pressure (MAP), PI, PVI were collected at the end of each stabilization period. RESULTS: @entity1 characteristics and baseline values of HR, MAP, PI and PVI were comparable between the groups. Carryover effect was statistically excluded. @entity2944 significantly increased PI and decreased PVI with significant negative correlation. CONCLUSION: @entity2944 retracts back PVI values compared with normocapnia. Precise judgment of fluid responsiveness as indicated by PVI necessitates its comparison against similar et @entity515 levels.

title: Effect of @entity2944 on pleth variability index during stable XXXX : Remifentanil anesthesia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity2944 :: ('MESH:D006935', 'Disease') :: ['Hypercapnia', 'hypercapnia']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['propofol']


abstract: BACKGROUND: Although the application of damage control surgery for @entity130 has been widely reported and defined, similar approach in non- @entity130 @entity1 has not been well detailed. METHODS: A retrospective analysis of data from non- @entity130 @entity1 who underwent emergency laparotomy between May 2006 and December 2008. Demographics, indications for surgery and outcome of @entity1 who had definitive laparotomies (DL) and @entity1 who had abbreviated laparotomies (AL) were compared. Appendectomies were excluded. RESULTS AND DISCUSSION: Two-hundred ninety-one @entity1 (55% males) were included. Thirty-one (10.7%) underwent AL (58% males). Mean age of @entity1 who had DL and AL was 65 and 62.8 years respectively. @entity298 and @entity5327 were more common indications in @entity1 with AL than DL: 48.4% vs. 30.4% (p = 0.04) and 32.3% vs. 3.5% (p < 0.0001) respectively. Only 29% of @entity1 who had AL were hemodynamically unstable. Mortality rates were 54.8% and 16.5% in @entity1 with AL and DL respectively (p < 0.0001). @entity1 who died after AL and DL were significantly older than @entity1 who survived (75 vs. 47.3 and 74 vs. 63 years respectively, p < 0.0001). Median hospital stay was 21 and 9 days for @entity1 with AL and DL respectively (p < 0.05). @entity1 who underwent AL had significantly more @entity2737 , @entity295 and @entity881 . CONCLUSION: The philosophy of damage control surgery is applied to non- @entity130 @entity1 as some of the prerequisites for the decision to elect this strategy are the same. @entity298 is the most common indication for AL in non- @entity130 @entity1 .

title: Abbreviated emergency laparotomy in the non- XXXX setting.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['Peritonitis']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['wound infections']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multi-organ failure']

entities_list: @entity5327 :: ('MESH:D065666', 'Disease') :: ['mesenteric ischemia']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: Arterial @entity6178 body ratio (AKBR) were examined in 114 cases of @entity253 . AKBR of the normal control was 1.47 +/- 0.38, while it remained less than 0.7 in @entity1575 , @entity157 ( @entity157 ), @entity5881 and @entity253 . AKBR correlated well with serum albumin and cholinesterase. Thirty five cases of @entity157 were treated with transcatheter @entity1416 (TAE), 20 cases with gelatin sponge and 15 cases without gelatin sponge. In cases with gelatin sponge AKBR decreased significantly immediately after TAE and recovered gradually during 24 hours. Without gelatin sponge AKBR decreased slightly and remained unchanged until 24 hours later. Concerning the prognosis after TAE, AKBR recovered well in cases with good prognosis, while in poor prognosis AKBR progressively decreased to below 0.3. In experimental TAE with gelatin sponge using @entity95 VX2-induced @entity96 , AKBR decreased significantly. In fatal @entity95 group after TAE, AKBR decreased progressively. Plasma endotoxin was also measured in TAE with experimental @entity95 , AKBR and endotoxin showed reverse correlation. From these results it was suggested that the measurement of AKBR is very useful for the evaluation of efficacy and prognosis of TAE in primary @entity96 .

title: [Changes in arterial @entity6178 body ratio after transcatheter XXXX for @entity157 -clinical and experimental studies].

entities_list: @entity5881 :: ('MESH:D008108', 'Disease') :: ['alcoholic liver diseases']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancer', 'liver tumor']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['hepato-biliary tract diseases', 'malignant biliary tract obstruction']

answer: @entity1416 :: (MESH:D020762,Disease) :: ['arterial embolization']