abstract: BACKGROUND: Except for overall survival, whether or not waiting time for treatment could influences other domains of @entity5 @entity1 ' overall well-being is to a large extent unknown. Therefore, we performed this study to determine the effect of waiting time for @entity5 treatment on the mental health of @entity1 with esophageal or @entity356 . METHODS: Based on the Swedish National Quality Register for Esophageal and @entity356 (NREV), we followed 7,080 @entity1 diagnosed 2006-2012 from the time of treatment decision. Waiting time for treatment was defined as the interval between diagnosis and treatment decision, and was classified into quartiles. @entity146 were identified by either clinical diagnosis through hospital visit or prescription of @entity146 medications. For @entity1 without any @entity146 before treatment, the association between waiting time and subsequent onset of @entity146 was assessed by hazard ratios (HRs) with 95% confidence interval (CI), derived from multivariable-adjusted Cox model. For @entity1 with a preexisting @entity146 , we compared the rate of @entity146 care by different waiting times, allowing for repeated events. RESULTS: Among 4,120 @entity1 without any preexisting @entity146 , lower risk of new onset @entity146 was noted for @entity1 with longer waiting times, i.e. 18-29 days (HR 0.86; 95% CI 0.74-1.00) and 30-60 days (HR 0.79; 95% CI 0.67-0.93) as compared with 9-17 days. Among 2,312 @entity1 with preexisting @entity146 , longer waiting time was associated with more frequent @entity146 hospital care during the first year after treatment (37.5% higher rate per quartile increase in waiting time; p for trend   =   0.0002). However, no such association was observed beyond one year nor for the prescription of @entity146 medications. CONCLUSIONS: These data suggest that waiting time to treatment for esophageal or @entity356 may have different mental health consequences for @entity1 depending on their past @entity146 vulnerabilities. Our study sheds further light on the complexity of waiting time management, and calls for a comprehensive strategy that takes into account different domains of @entity1 well-being in addition to the overall survival.

title: Waiting time for @entity5 treatment and mental health among @entity1 with newly diagnosed esophageal or XXXX : a nationwide cohort study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'Gastric Cancers']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders', 'psychiatric', 'mental disorder', 'Mental disorders']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: BACKGROUND: This study examines whether two different physiotherapy regimes used in rehabilitation after acute @entity64 have any differences in outcome. MATERIAL AND METHODS: A double-blind study of @entity1 with acute first-ever @entity64 . 61 @entity1 were consecutively included, block-randomized into two groups and stratified according to gender and hemispheric location. Group 1 (33 @entity1 ) received physiotherapy in the hospital's @entity64 unit according to the Motor Relearning Programme (MRP), group 2 (28 @entity1 ) according to the Bobath method. Supplemental treatment did not differ. The Motor Assessment Scale (MAS), the S  dring Motor Evaluation Scale (SMES), the Barthel ADL (Activities of Daily Living) Index, and the Nottingham Health Profile (NHP) were used as outcome measures. The following variables were also registered: length of stay in hospital, use of assistive devices for mobility, and @entity1 ' accommodation after discharge. RESULTS: @entity1 treated according to the MRP had shorter stays in hospital compared to those treated according to Bobath (mean 21 days vs. 34 days, p < 0.01). Both groups improved on MAS and SMES, but motor functions improved significantly better in the MPP group. Both groups improved on the Barthel Index; there were no significant differences between the groups, though @entity1 treated by MRP improved more than @entity1 treated by Bobath. There were no differences between the groups in NHP scores, use of assistive devices or accommodation after discharge. INTERPRETATION: This study indicates that physiotherapy according to the MRP is preferable to the Bobath programme in the rehabilitation of @entity64 @entity1 .

title: [Physiotherapy after XXXX --a randomized controlled trial].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'Patients']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: The cardiovascular effects of @entity50620 -4 were evaluated in @entity35 and @entity235 . In conscious @entity35 , @entity50620 -4 (3-30 mg/kg p.o.) produced a dose-dependent @entity551 effect without increasing heart rate (HR) and plasma @entity3449 activity (PRA). @entity594 (3-10 mg/kg p.o.) produced a dose-dependent @entity551 effect but significantly increased HR and PRA. @entity2165 (30 mg/kg p.o.) decreased PRA but did not decrease blood pressure and HR. The cardiovascular effects of the combination of @entity594 and @entity2165 were similar to those of @entity50620 -4. It is interesting that the time course of the @entity551 effect of @entity50620 -4 was similar to that of its @entity10343 blocking effect, although the time courses of these effects of the combination of @entity594 and @entity2165 were different. In conscious @entity235 , @entity50620 -4 (0.3-10 mg/kg p.o.) also produced a long-lasting @entity551 effect with almost no effect on HR and PQ-interval. The time course of the @entity10343 blocking effect was similar to that of its @entity551 effect. Furthermore, during 10-day repeated oral administration, neither tolerance nor augmentation was observed in the @entity551 and @entity10343 -blocking effects. In conclusion, the present results indicate that @entity50620 -4 is an effective and long-lasting @entity551 agent that does not increase HR and PRA. These effects of @entity50620 -4 may be attributable to its @entity460 -entry-blocking and @entity10343 -blocking activities, and the ratio of two activities was constant after single and repeated oral administrations.

title: Cardiovascular effects of @entity50620 -4: a novel @entity460 entry blocking and selective @entity10343 blocking agent in @entity35 and XXXX .

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['Atenolol', 'atenolol']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine', 'Nifedipine']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: Intra-vascular access is an unavoidable tool in sophisticated modern medical practice, and @entity1212 remains a leading cause of @entity580 , particularly in intensive care units where it is associated with significant @entity1 morbidity, mortality, and additional hospital costs. The incidence of catheter-related bloodstream @entity281 ranges from 2 to 14 episodes per 1000 catheter-days. On average, microbiologically documented, device-related bloodstream infections complicate the use of a central venous line in three to five per 100 cases. But this represents only the visible part of the iceberg and most episodes of @entity922 are nowadays considered to be catheter-related. We briefly review the pathophysiology of these infections, highlighting the importance of the skin insertion site and the intravenous line hub as principal sources of colonization and @entity281 . Principles of therapy are briefly addressed. A large proportion of these infections are preventable and this has been the objective of creating precise guidelines. It was recently suggested that the situation may evolve with the introduction of antibiotic/antiseptic-coated devices, whose impact on the epidemiology of antibiotic resistance remains to be determined. Recently, educational programs and/or a global preventive strategy based on the strict application of specific preventive measures and careful control of all factors associated with @entity281 proved to be even more effective than coated devices in reducing rates of @entity281 . Practical aspects regarding educational approaches will help clinicians to adapt and incorporate educational programs into clinical practice.

title: Overview of XXXX with special emphasis on prevention based on educational programs.

entities_list: @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter-related infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['nosocomial infections']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['clinical sepsis']

answer: @entity1212 :: (MESH:D055499,Disease) :: ['catheter-related infections']


abstract: OBJECTIVE: To determine clinical and bacteriological efficacy and tolerability of @entity2889 and @entity2892 / @entity9234 , given intravenously, in the treatment of @entity1320 in hospitalized @entity1 . EXPERIMENTAL DESIGN: Open multicentre, randomized, parallel groups clinical trial, comparing @entity2889 and @entity2892 / @entity9234 . ENVIRONMENT: Six Italian hospitals. @entity1 : Eighty-six hospitalized @entity1 , aged 16 or more, with @entity1320 requiring parenteral antibiotic therapy, were randomized to two treatment groups (43 on @entity2889 , 43 on @entity2892 / @entity9234 ). Eighty-four @entity1 completed the study and 2 were excluded from efficacy analysis. TREATMENT: @entity2889 and @entity2892 / @entity9234 were administered intravenously at 1 g TID. Dosage was reduced in @entity1 with @entity8 . Mean treatment duration in clinically evaluable @entity1 was 7.0 days in @entity2889 group and 7.6 days in @entity2892 / @entity9234 group. MEASUREMENTS: Clinical efficacy evaluated at the end of the therapy and 2-4 weeks after. Bacteriological efficacy before, during, and immediately after the end or the modification of the experimental treatment. All adverse events were recorded. RESULTS: 42/43 (98%) @entity1 on @entity2889 and 39/41 (95%) on @entity2892 / @entity9234 had satisfactory clinical response. In both groups bacteriological response was satisfactory in 26/27 (96%) evaluable @entity1 . No statistically significant differences were found, both for clinical and bacteriological efficacy. Only two adverse reaction to study drug were observed (1 rash per treatment group). CONCLUSIONS: @entity2889 , broad spectrum antibiotic with high stability to @entity1 renal DHP-1, given alone for the treatment of @entity1320 is as effective and well tolerated as @entity2892 / @entity9234 .

title: [ XXXX (Merrem) vs @entity2892 / @entity9234 in hospital treatment of @entity1320 . A multicenter study].

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment']

entities_list: @entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem']

entities_list: @entity9234 :: ('MESH:D015377', 'Chemical') :: ['cilastatin']

entities_list: @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem', 'Meropenem']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal infections']

answer: @entity2889 :: (MESH:C059500,Chemical) :: ['Meropenem']


abstract: OBJECTIVE: To report a @entity944 in a female carrier of @entity12654 and to describe the @entity299 associated with this disease. STUDY DESIGN: Case series. SETTING: University hospital. @entity1 : A 45-year-old carrier who died suddenly and two affected @entity1 who also died of cardiac manifestations of @entity12654 . MEASUREMENTS: Post-mortem gross pathologic and histopathologic study of the heart. RESULTS: All three hearts showed a unique pattern of pathologic findings. Marked loss of @entity955 had occurred. Myocardium had been replaced by adipose and fibrous tissue. The conduction system showed no significant abnormalities. Varying degrees of interstitial and replacement @entity82 were present in the ventricular myocardium. CONCLUSIONS: @entity12654 is associated with characteristic pathologic changes in the heart that can cause @entity204 in female carriers and affected @entity1 . Female carriers should be identified and evaluated because of the risk for @entity1164 .

title: @entity944 of a carrier of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'men']

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac abnormalities']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial myocardium']

entities_list: @entity12654 :: ('MESH:D020389', 'Disease') :: ['Emery-Dreifuss muscular dystrophy']

answer: @entity12654 :: (MESH:D020389,Disease) :: ['X-linked Emery-Dreifuss muscular dystrophy']


abstract: BACKGROUND AND PURPOSE: Cerebral sinovenous @entity715 is a @entity395 with a high risk of an adverse neurodevelopmental outcome. Until now, anticoagulation therapy has been restricted to neonates without an associated @entity548 . In this study, we describe sequential neuroimaging findings and use of anticoagulation therapy in newborn @entity1 with a unilateral @entity548 due to @entity5892 . METHODS: Ten neonates with a unilateral @entity548 and @entity5892 were studied. Diagnosis was suspected using cranial ultrasound and confirmed with MRI/MR venography. Eight @entity1 had a repeat MRI at 3 to 7 months. Neurodevelopmental outcome was assessed from 3 months until 5 years. RESULTS: One @entity1 died. Seven @entity1 were treated with low-molecular-weight heparin. No side affects were noted. MRI showed involvement of multiple sinuses, additional @entity548 , and @entity62 in all @entity1 . Recanalization was present on the repeat MRI at 3 months in all @entity1 . Treatment was delayed in one infant and anticoagulation was started only after extension of the @entity548 . He required a ventriculoperitoneal drain for posthemorrhagic @entity2554 and developed cerebral @entity227 and global delay. Two other @entity1 showed global delay and one of them also developed @entity302 . Mild asymmetry in tone was present in 4 @entity1 . CONCLUSIONS: Cerebral sinovenous @entity715 was found in 10 neonates with unilateral @entity548 . Diagnosis was suspected on cranial ultrasound and confirmed with MRI/MR venography. Treatment with low-molecular-weight heparin in newborn @entity1 with a @entity548 due to @entity5892 appears to be safe and should be considered. Long-term follow-up will be needed to assess cognitive outcome.

title: Anticoagulation therapy and imaging in neonates with a unilateral XXXX due to @entity5892 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infants', 'infant']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment']

entities_list: @entity5892 :: ('MESH:D020767', 'Disease') :: ['cerebral sinovenous thrombosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['parenchymal hemorrhage', 'thalamic hemorrhage', 'intraventricular hemorrhage']

entities_list: @entity2554 :: ('MESH:C563906', 'Disease') :: ['ventricular dilatation']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['postneonatal epilepsy']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions']

answer: @entity548 :: (MESH:D006470,Disease) :: ['thalamic hemorrhage']


abstract: Clinical definition of @entity484 is based on the presence of multiform erythematous, papular and @entity75 which are followed by marked desquamation. When the underlying mechanism is @entity56 , @entity272 are mediated by inflammatory @entity1198 lymphocytes recognizing hapten determinants, i.e. IVth @entity56 mechanism in @entity3408 . This mechanism is responsible also for @entity566 , or to fungal and bacterial proteins, atopens and @entity3406 in @entity38807 . @entity75 can develop after damage to the skin barrier by toxic chemical or irritating substances, as @entity146 . These substances non-specifically stimulate the Langerhans cells and keratinocytes to produce numerous cytokines inducing expression of adhesion molecules on the endothelial cells. This is responsible for non-specific mobilization of @entity1198 cells to the skin. A model example is @entity1909 induced by @entity349 salts and/or @entity3208 . Intermediate position between @entity56 and @entity56 is occupied by @entity1097 . In addition to classical IgE-dependent mechanism leading to degranulation of mast cells, there is generation of specific population of Th2 lymphocytes recognizing food and air-borne atopens. This reaction is responsible for @entity32 in the late-phase response, in which @entity56 started by Th2 cells switches to non-specific migration of @entity1198 cells attracted by cytokines released from eosinophils, keratinocytes and Th2 lymphocytes.

title: [Allergic contact XXXX ].

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['skin inflammation']

entities_list: @entity3408 :: ('MESH:D017449', 'Disease') :: ['allergic contact dermatitis']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium lauryl sulfate']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['non-allergic irritation eczema']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Eczematous lesions', 'vesicular lesions']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy to bacterial proteins in nummular eczema']

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

entities_list: @entity1097 :: ('MESH:C566404', 'Disease') :: ['atopic dermatitis/eczema']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['non-allergic eczema', 'allergic', 'allergic process']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

entities_list: @entity38807 :: ('MESH:D011146', 'Disease') :: ['dyshidrotic eczema']

answer: @entity1909 :: (MESH:D003872,Disease) :: ['dermatitis']


abstract: Ten @entity1 with a tethered cord and also an @entity2463 are reported in this document. The @entity2463 comprised 5 vesicointestinal fissures, 2 cloacal exstrophies, 2 rectovesical fistulas and 1 rectobulbar fistula. All of the @entity1 underwent colostomy in advance of surgery for untethering of the spinal cord. Although their @entity51 had previously been considered static, they were subjected to radiographic examination of the caudal spine and found to have a tethered cord. These 10 @entity1 were among 55 @entity1 with a tethered cord surgically treated at the Division of Neurosurgery of the Osaka Medical Center and Research Institute for Maternal and @entity1 Health during the last 11 years. Data were obtained for these 10 @entity1 (6 @entity1 and 4 @entity1 , mean age 1.7 years) who underwent surgical untethering. Several hypotheses are offered to explain this association. @entity2463 are related to underlying @entity602 , which may be amenable to neurosurgical correction. Eight of our @entity1 had no skin stigma of the lumbosacral region, in contrast to an ordinary tethered cord. Spinal cord imaging is necessary to closely scrutinize these @entity1 .

title: Tethered cord associated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children', 'patients', 'girls', 'boys']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficits']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord anomalies']

entities_list: @entity2463 :: ('MESH:C537771', 'Disease') :: ['anorectal malformations', 'anorectal malformation', 'Anorectal malformations']

answer: @entity2463 :: (MESH:C537771,Disease) :: ['anorectal malformation']


abstract: OBJECTIVES: To investigate persistence and adherence of medication treatment in chronic @entity2182 /urinary incontinence (OAB/UI) @entity1 , and to evaluate OAB/UI-related comorbidity events associated with persistence. METHODS: Pharmaceutical outcomes research with a health-care provider perspective was conducted on a California Medicaid (Medi-Cal) chronic OAB/UI population. The primary end point was medication possession ratio (MPR), which was used to measure refill adherence. Secondary end points measuring persistence patterns included discontinuation of OAB drug therapy (medication-uncovered interval > 30 days) and time to discontinuation (period from the index date until the first discontinuation date). Significant factors on nonpersistence were found by using a Cox Proportional Hazards model. Factors contributing to nonadherence (MPR < 0.8) and the relationship between OAB/UI comorbidity events and persistence were examined by logistic regressions. RESULTS: Of 2496 eligible @entity1 , 36.9% had only one OAB/UI prescription. The mean MPR was 0.34 (SD 0.21) and the median was 0.3, indicating that on average only about one-third of period of time since medication initiation was covered by the therapy. Only 122 @entity1 exhibited > 80% adherence during the 6-month follow-up-period. Significant predictors of higher persistence included: white ethnicity, previous hospitalization length, starting with @entity2181 or @entity11440 extended-release, and previous use of topical drugs or antipsychotics. Nevertheless, previous @entity293 ( @entity293 ) diagnosis, polypharmacy, significantly increased the odds of early discontinuation. Treatment discontinuation increased the risk of @entity293 diagnosis by 37% in the post-treatment period (P = 0.03; OR 1.37; 95% CI 1.03-1.84), but had no significant effect on other OAB/UI-related comorbidities. CONCLUSIONS: For chronic OAB/UI @entity1 identified in this study, both persistence and adherence with medication treatment were suboptimal. These results suggest that persistence and treatment discontinuation remains problematic for the OAB/UI population.

title: Persistence and adherence of medications for chronic XXXX /urinary incontinence in the california medicaid program.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2181 :: ('MESH:C099041', 'Chemical') :: ['tolterodine']

entities_list: @entity11440 :: ('MESH:C005419', 'Chemical') :: ['oxybutynin']

entities_list: @entity2182 :: ('MESH:D053201', 'Disease') :: ['overactive bladder']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['depression or urinary tract infection', 'UTI']

answer: @entity2182 :: (MESH:D053201,Disease) :: ['overactive bladder']


abstract: Thirty two @entity1 with active @entity30 were included in a controlled randomised trial to determine the efficacy and safety of polymeric enteral nutrition compared with @entity230 , to achieve and maintain clinical remission. The polymeric diet was administered through a fine bore nasogastric tube by continuous, pump assisted infusion (2800 (SEM 120) kcal/day). The @entity134 group received 1 mg/kg/day of @entity229 . Both treatments were effective in inducing clinical remission: 15 of the 17 @entity1 given @entity230 and 12 of the 15 @entity1 assigned to the polymeric diet went into clinical remission (defined by a Van Hees index < 120) within four weeks of treatment. The percentage reduction of the Van Hees index was 34.8 (4.9)% for @entity230 and 32.3 (5)% for enteral nutrition (mean difference 2.5%; 95% CI--11.8% to +16.8%). Mean time elapsed to achieve remission was similar in both groups (2.0 (1) v 2.4 (1.2) weeks). Tolerance of the enteral diet was excellent. Four @entity1 in the @entity134 group had mild complications attributable to this treatment. Ten @entity1 (66.6%) in the @entity134 group and five (41.6%) in the enteral nutrition group relapsed within a year of discharge, but no differences were found in the cumulative probability of relapse during the follow up period. These results suggest that polymeric enteral nutrition is as safe and effective as @entity230 in inducing short term remission in active @entity30 .

title: Polymeric enteral diets as primary treatment of active @entity30 : a prospective XXXX controlled trial.

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

answer: @entity134 :: (CHEBI:35341,Chemical) :: ['steroid']


abstract: PURPOSE: To examine the cost-effectiveness of radiation therapy following conservative surgery for @entity0 . METHODS: Using a Markov model, a cost-utility analysis was performed to compare a strategy of radiation therapy versus no radiation therapy in a hypothetical cohort of 60-year-old @entity1 following conservative surgery. Local recurrence, distant recurrence, and survival rates used in the model were derived from randomized trial data. Utilities for the nonmetastatic health states were collected from actual @entity1 . Direct medical costs were estimated using data from a single institution. Transportation and time costs were also estimated. Years of life, quality-adjusted life-years (QALYs), costs, and incremental cost/QALY over a 10-year time horizon were calculated by the model for each strategy. RESULTS: The addition of radiation therapy results in a cost increase of  9,800 per @entity1 , no change in life expectancy, and an increase of 0.35 QALYs per @entity1 , which leads to an incremental cost-effectiveness ratio of  28,000/QALY, which is well below  50,000/QALY, a commonly cited threshold for cost-effective care. Sensitivity analysis shows the ratio to be heavily influenced by the cost of radiation therapy and the quality-of-life benefit that results from decreased risk of local recurrence. CONCLUSION: Radiation therapy following conservative surgery is cost-effective compared with other accepted medical interventions. This study illustrates the importance of considering an intervention's effect on quality of life, as well as survival in defining cost-effectiveness.

title: Cost-effectiveness of routine radiation therapy following conservative surgery for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['early-stage breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['early-stage breast cancer']


abstract: This study investigates cellular alterations after directional atherectomy @entity130 ( @entity6684 ) in an experimental model in 50 @entity1707 . Two hundred arteries were excised at eight different times (2 hours to 21 days) after @entity6684 and were examined by electron microscopy and immunohistochemistry. The extent of injury varied with the number of repetitive passes of the atherectomy catheter. According to the extent of injury the vessel segments with @entity6684 were assigned to three groups: intima injury (group 1), media injury (group 2), and @entity130 (group 3). A myoproliferative response was found in relation to @entity92 , increasing from group 1 (ratio tissue @entity1373 /media: 0.3 +/- 0.2; p < 0.001) to group 2 (ratio tissue @entity1373 /media: 1 +/- 0.5) and group 3. Intense neutrophil infiltration occurred in groups 2 and 3 (peak 12 hours after @entity6684 ) and was followed by the early occurrence of synthetic smooth-muscle cells (SMC; > 50% of all SMC present). Volume fraction of @entity62714 and actin was transiently reduced in injured media and myoproliferative tissue (7d: 9% vs > 90% normal media). SMC proliferation started in groups 2 and 3 at 48 hours and peaked at 7 days (+500% vs normal media, p < 0.001). After @entity6684 was done, vascular response started immediately and depended on @entity130 . A transient myoproliferative response resulted, correlating with the extent of vessel @entity130 .

title: Experimental directional atherectomy injury in arterial vessels: impact of XXXX depth on cellular response.

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity92 :: ('MESH:D007222', 'Disease') :: ['DI depth']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['adventitia injury', 'injury depth', 'trauma', 'vessel injury']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: The @entity1 was a 38-year-old @entity1 . He had been suffering from @entity1751 ( @entity1751 ) for approximately 20 years. He had active lesions at both axillas, hip, scrotum, and perineum, and inactive lesions located behind the ears, lower abdomen, and posterior neck. He was monitored and treated at different branches; he continuously used antibiotics and was given steroids at times. Antibiotic resistance developed subsequently. His general situation was bad; vital signs were poor; and he was in a state of @entity295 and preshock, so this case was regarded as life-threatening. Total excision was performed first on the lesion at the @entity4265 , then on the lesion at the @entity1002 , and the parascapular fasciocutaneous flap was reversed. A skin graft was applied to the @entity154 . No relapse occurred. Then the lesions at the hip were managed. Broad excision was used twice with the @entity1 under general anesthesia; because the lesions spread to the retrococcygeal and gluteal muscles, coccyx resection and partial gluteal muscle resection were implemented. The defect was eliminated with a progressive flap. At the intergluteal sulcus, small lesions emerging at the median line were debrided with the @entity1 under local anesthesia, and together with secondary recovery, the disease was completely managed. Lesions at the perineum and scrotum and at both inguinal areas were broadly excised and grafted. No lesion has relapsed so far. One year later, @entity978 was diagnosed, and the @entity1 was treated with chemoradiotherapy easily, because there was no infective focus. The disease is in remission now. The @entity1 weighs 110 kg, is healthy, and is working again.

title: A life-threatening multilocalized XXXX case.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['triangular defect on the scapula']

entities_list: @entity1751 :: ('MESH:D017497', 'Disease') :: ['hidradenitis suppurativa', 'HS']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's lymphoma"]

entities_list: @entity4265 :: ('MESH:C535682', 'Disease') :: ['right axilla']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left axilla']

answer: @entity1751 :: (MESH:D017497,Disease) :: ['hidradenitis suppurativa']


abstract: PURPOSE: The aim of this study is to investigate whether subserosal enhancement on the delayed-phase dynamic magnetic resonance (MR) study ( @entity11736 ) can differentiate T2 from T1 @entity1086 ( @entity1086 ). METHODS: The institutional research board approved this retrospective study. Between 1997 and 2006, there were surgically proven 11 T1 and 21 T2 @entity1086 in 30 @entity1 , all of whom had undergone preoperative contrast enhanced dynamic MR study, either with a 2D sequence (n=17) or 3D sequences (n=15). All images were reviewed by two radiologists for the presence of @entity11736 , and receiver operating characteristic (ROC) curve analysis was performed. Sensitivity, specificity, positive and negative predictive values were calculated by consensus. RESULTS: The areas under the ROC curves of the two readers were 0.91 and 0.86, and the kappa value was 0.78. Of the 21 T2 @entity1086 , 18 and 3 showed positive and negative @entity11736 , respectively. Of the 11 T1 @entity1086 , 1 and 10 showed positive and negative @entity11736 , respectively. The sensitivity, specificity, positive and negative predictive values of @entity11736 for diagnosing T2 lesions were 86%, 88%, 91% and 77%, respectively. CONCLUSIONS: In conclusion, @entity11736 may be a useful sign to differentiate T2 from T1 @entity1086 , which would affect the preoperative surgical planning of the @entity1 .

title: Magnetic resonance differentiation between T2 and T1 XXXX : significance of subserosal enhancement on the delayed phase dynamic study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1086 :: ('MESH:D005706', 'Disease') :: ['gallbladder carcinoma', 'GBC']

answer: @entity1086 :: (MESH:D005706,Disease) :: ['gallbladder carcinoma']


abstract: Autoimmunity in @entity4789 ( @entity4789 ) is triggered by group-A beta hemolytic streptococci (GAS). Although most of the recent work has focused on the major impact of lymphocytes, the exact immunopathogenesis is still unresolved. Regulation of self-tolerance in response to GAS has been investigated in various animal experiments. This study aimed to associate the ratio of lymphocytes bearing adhesion/costimulatory molecules, @entity588 / @entity1197 and serum @entity2533 concentrations with clinical stages of @entity4789 . Thirty-five @entity1 were assigned according to the clinical stages. @entity588 expression on @entity1075 + and CD3+ lymphocytes was similar within @entity1 groups and controls. @entity8729 expression was higher in @entity1 with @entity2401 . The ratio of @entity2071 bearing lymphocytes was significantly different between @entity1 groups and controls and was increased through acute to remission stages longitudinally. In contrast, a gradual and significant decrease in @entity2533 concentrations was observed longitudinally from acute to chronic stages. A positive correlation has been documented between @entity2071 + lymphocyte ratios and Fas+ cytotoxic T cell ratios supported by a prominent increase in @entity1197 + T cells. These data draw our attention to the role of @entity2071 , Fas and @entity2533 in @entity4789 pathogenesis through the perspective of self-tolerance in a clinical setting.

title: Inverse relationship between the ratio of @entity2071 expressing lymphocytes and serum XXXX concentrations in @entity4789 .

entities_list: @entity4789 :: ('MESH:D012213', 'Disease') :: ['ARF', 'acute rheumatic fever']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity2533 :: (7040,Gene) :: ['TGF-beta 1']


abstract: This review of 121 @entity1 with @entity4802 ( @entity4802 ) revealed that 67 (55.4%) had @entity154 . Sixteen @entity1 (13%) had one extracraniofacial @entity154 and 51 @entity1 (42.4%) had anomalies of multiple organ systems. There was no gender or side predominance in the cohort with the @entity4802 "expanded spectrum." Central nervous system (CNS), @entity299 were "associated" (i.e., had frequencies of 10% or more). Pulmonary, gastrointestinal, and @entity8 were equivocally associated. Statistical analysis indicated significant associations between several orbital, mandibular, ear, neural, and soft tissue (OMENS) variables and @entity154 . @entity1 with extracraniofacial structural defects had higher OMENS grades for individual craniofacial anatomic categories. Furthermore, @entity1 with expanded spectrum had higher total OMENS scores. The frequency of @entity299 (26%) supports the model of neural crest involvement in the pathogenesis of both @entity4802 and conotruncal defects. The majority of the @entity299 in this study were of either the outflow or septal type. We propose that the OMENS classification system for @entity2122 of @entity4802 be expanded to OMENS-Plus (+) to designate the presence of associated @entity154 .

title: OMENS-Plus: analysis of craniofacial and XXXX in @entity4802 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['anomaly', 'extracraniofacial anomalies']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal deformities']

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['craniofacial anomalies']

entities_list: @entity4802 :: ('MESH:D006053', 'Disease') :: ['HFM', 'hemifacial microsomia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart defects', 'cardiac, and skeletal anomalies', 'cardiac anomalies']

answer: @entity154 :: (MESH:D000013,Disease) :: ['extracraniofacial anomalies']


abstract: BACKGROUND: @entity189 are among the most rarely found @entity1489 (0.2 - 4.6 %). As with most @entity1489 the predominant region of occurrence is the head and neck, in particular the eyelids. The cytological origins are foremost the Meibomian and the glands of Zeis. CASE REPORTS: We report on two female @entity1 suffering from @entity189 of the upper and lower lid. The time span from initial treatment up to definite diagnosis and treatment was one year. In both cases the @entity5 was radically removed surgically and the eyelid reconstructed. In the first case there was no @entity5 recurrence within six years after surgery. In the second case a lymph node @entity3 of the parotid gland was found seven years after initial therapy and surgically removed followed by a complete parotidectomy and neck dissection. DISCUSSION: As the sebaceous @entity189 are difficult to differentiate from other kinds of benign and @entity5 , a considerable delay between the initial examination and final diagnosis is not uncommon. This type of @entity5 is characterised by a high degree of biological aggression concerning local recurrence and @entity5 spread. The mortality rate is reported to be between 9 and 40 %. Therapy of choice is the radical surgical @entity5 . Depending on preoperative findings, neck dissection may be indicated. The biological behaviour of this kind of @entity5 requires long-term oncological aftercare.

title: [ XXXX of the eyelids--case reports and review of the literature].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant eyelid diseases', 'removal of the tumour', 'lymphogenous and hematogenic tumour', 'tumour']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin tumours']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Sebaceous carcinomas', 'carcinomas', 'sebaceous carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity189 :: (MESH:D002277,Disease) :: ['Sebaceous carcinoma']


abstract: AIM: Little is known about the relationship between @entity20319 Codon399 polymorphisms and radiotherapy (RT) outcomes in @entity1 with @entity189 ( @entity189 ). We aimed to investigate whether @entity20319 Codon399 polymorphisms were correlated to treatment efficacy and normal tissue @entity137 in Chinese @entity1 with locally advanced @entity189 after RT. METHODS: Sixty eligible @entity1 with @entity189 stage III-IVa were recruited. @entity1 received definitive RT, 66-76   Gy. One cycle neoadjuvant chemotherapy with @entity1205 and @entity900 regimen was used before RT, two or three cycles for concurrent chemo-RT followed by two to four cycles adjuvant chemotherapy with the same regimen. Before the treatment, @entity20319 Codon399 polymorphisms were determined by polymerase chain reaction based ligase detection reaction methods. RESULTS: Six of 60 @entity189 @entity1 were homozygous for @entity20319 Codon399 @entity7647 / @entity7647 and 35% were heterozygous. The expressions of genotypes were unrelated to gender, age, clinical stage, T stage or N stage. Codon399 @entity7647 / @entity7647 allele correlated with a higher medium-term @entity5 regression ratio after RT for primary @entity61047 and metastatic lymph nodes (>80% vs 40-60%, P   <   0.01). Compared with other two genotypes, @entity1 with @entity20319 Codon399 @entity7647 / @entity7647 allele were more likely to obtain complete remission of @entity5 (100% vs 76 and 67%, P   >   0.05). No correlation between @entity20319 Codon399 polymorphisms and acute or late radiation-induced injury of normal tissues was observed. CONCLUSIONS: The @entity20319 Codon399 @entity7647 / @entity7647 allele may be associated with better @entity5 regression, and is suggested as a promising predictive factor for outcome for locally advanced @entity189 . Further study with larger samples and long-time follow-up is needed for accurate assessment.

title: Significance of XXXX Codon399 polymorphisms in Chinese @entity1 with locally advanced @entity189 treated with radiation therapy.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity61047 :: ('MESH:D009303', 'Disease') :: ['nasopharyngeal neoplasm']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

answer: @entity20319 :: (7515,Gene) :: ['XRCC1']


abstract: BACKGROUND: Dysfunction of the meibomian glands with @entity32 and obstruction has been suggested to be an important factor in the pathogenesis of chronic @entity14985 . Few objective tests are, however, available to examine the meibomian glands directly. @entity1 AND METHODS: Nineteen @entity1 with anterior @entity14985 , meibomitis, @entity409 or severe @entity9849 sicca associated with @entity14985 as well as 10 @entity1 with normal lid margins were examined with the HRTII/ @entity11857 in vivo confocal microscope. Scans of the tear film, the tarsal conjunctiva, the hair follicles and the meibomian glands were analysed by a masked observer. RESULTS: @entity1 with normal lid margins exhibited a minimal round cell infiltrate in the tarsal conjunctival epithelium and largely normal ducts of the meibomian glands lined with a multilayered epithelium as well as normal gland acini. In @entity1 with anterior @entity14985 , @entity14985 associated with autoimmune peripheral @entity3283 and @entity14985 in the context of severe @entity936 , confocal microscopy disclosed normal meibomian glands. In 12 @entity1 with @entity14985 /meibomitis or @entity409 , profound pathology was visible with dilatation and obstruction of the meibomian gland ducts. In 15 of 19 @entity1 with @entity14985 /meibomitis, but not in @entity409 , an intense @entity32 was observed in the tarsal conjunctival epithelium and stroma. In one @entity1 , demodex folliculorum was evident in vivo. In @entity1 with normal lid margins as well as in @entity1 with @entity14985 , hair follicles appeared within normal limits. CONCLUSIONS: In vivo confocal microscopy allowed the examination of the tear film, the tarsal conjunctiva, the lid margin including the lash follicles and the meibomian glands. In @entity1 with meibomian gland disease pathological changes could be visualised and documented objectively. The presence of an inflammatory infiltrate permitted us to differentiate between meibomitis and @entity409 . Changes of the lash follicles do not seem to play an important role in @entity14985 . Thus, in vivo confocal microscopy represents an objective technique in the classification and follow-up of @entity1 with @entity14985 .

title: [In vivo confocal microscopy in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity9849 :: ('MESH:D007637', 'Disease') :: ['keratoconjunctivitis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['meibomian gland dysfunction']

entities_list: @entity14985 :: ('MESH:D001762', 'Disease') :: ['blepharitis']

entities_list: @entity3283 :: ('MESH:D003320', 'Disease') :: ['ulcerative keratitis']

answer: @entity14985 :: (MESH:D001762,Disease) :: ['blepharitis']


abstract: In previous experiments it was shown that repeated mechanical or immunologic injury to the arterial intima of normally fed @entity95 induced lesions morphologically identical with @entity1 @entity731 . These regressed in size and lipid content when the injury stimulus was removed. By contrast, repeated injury directed to removal of only the endothelial layer induced lesions in which lipid accumulated in areas of endothelial regeneration and increased with time. In the present report the lesions associated with multiple and with a single episode of endothelial removal, using a Fogarty balloon catheter, are compared. Lipid accumulates in areas of endothelial regrowth following one @entity130 and is similar in amount to that at comparable time intervals following the first of @entity661 of the endothelium. There is much more lipid in areas of endothelial regrowth than in areas that remain uncovered by endothelium, the lipid tends to increase with time, and there is more lipid in the abdominal aortic than in the @entity2333 . A correlation was found between lipid content and @entity75 , especially in response to multiple removals of the endothelium. Multiple removals resulted in thicker lesions than a single injury. There appeared to be a positive relationship between the level of blood @entity165 and the amount of lipid deposited in areas of endothelial regrowth. This is consistent with trapping of low density lipoprotein by glycosaminoglycans in the @entity8233 covered by regenerated endothelium.

title: Lipid accumulation in the XXXX formed in normally fed @entity95 in response to one or six removals of the aortic endothelium.

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['thickness of lesions']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['multiple balloon removals']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['thoracic aortic lesions']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['endothelial injury']

entities_list: @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']

answer: @entity8233 :: (MESH:D058426,Disease) :: ['neointima']


abstract: BACKGROUND: Despite few studies, a monitoring of a @entity4094 with a @entity3370 ( @entity3370 ) is recommended in @entity1213 ( @entity1213 ). Our objective was to compare the results of ulnar and @entity2652 measurements with an overall clinical assessment for @entity4094 in @entity1213 @entity1 treated with recommended doses of @entity5159 or @entity2897 , including @entity1 with @entity6185 ( @entity6185 ). METHODS: We prospectively included in two ICUs 119 @entity1 , 94 with @entity6185 , who required a @entity4094 for more than 24  h. Three levels of @entity4094 were defined: "over-paralyzed" ( @entity3370  =  0), "well-paralyzed" ( @entity3370  =  1-2), and "under-paralyzed" ( @entity3370  =  3-4). Physicians blinded for @entity3370 counts were asked to classify @entity1 clinically as "over-paralyzed," "well-paralyzed," or "under-paralyzed". @entity1 were assessed two times daily. RESULTS: For the whole population 996 ulnar and @entity2652 measurements and clinical assessments were obtained (846 with @entity2897 and 150 with @entity5159 ). Proportions of @entity1 classified as over-paralyzed, well-paralyzed, and under-paralyzed based on @entity3370 measurements and clinical assessments differed significantly (p  <  0.0001). The number of observed agreements between clinical assessments and @entity2652 measurements was of 19.08% (k  =  0.06) and of 17.37% with ulnar @entity3370 measurements (k  =  0.04), while it was of 62.75% between ulnar and @entity2652 measurements (k  =  0.45). Results were similar for @entity2897 and @entity5159 . Repeated @entity2652 measurements performed on the first 4  days of mechanical ventilation in @entity6185 @entity1 showed that the proportion of @entity1 @entity3370  =  1-2 was around 8% and did not vary significantly with time (p  =  0.9), proportion of @entity1 @entity3370  =  3-4 increased from 24 to 40% (p  =  0.01), proportion of @entity1 @entity3370  =  0 decreased from 71 to 53% (p  =  0.005) while objectives for protective ventilation were achieved. Proportions of facial and ulnar @entity3370  =  0 were significantly higher among @entity1 with @entity1213 -acquired weakness ( @entity1213 -AW) versus those who did not develop @entity1213 -AW (51 vs. 40%, p  =  0.03, and 76 vs. 62%, p  =  0.006, respectively). CONCLUSIONS: The study provides data on clinical and @entity3370 monitoring of @entity4094 , which are widely divergent in @entity1213 @entity1 receiving recommended doses of benzylisoquinoliniums.

title: Clinical assessment and train-of-four measurements in critically ill XXXX treated with recommended doses of @entity2897 or @entity5159 for @entity4094 : a prospective descriptive study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular blockade']

entities_list: @entity5159 :: ('MESH:D001279', 'Chemical') :: ['atracurium']

entities_list: @entity6185 :: ('MESH:D045169', 'Disease') :: ['ARDS', 'acute respiratory disease syndrome']

entities_list: @entity2652 :: ('MESH:D005148', 'Disease') :: ['facial TOF']

entities_list: @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care unit', 'ICU']

entities_list: @entity3370 :: ('MESH:C538154', 'Disease') :: ['train of four', 'TOF']

entities_list: @entity2897 :: ('MESH:C101584', 'Chemical') :: ['cisatracurium']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Optimism is thought to be beneficial for health, and these effects may be mediated through modifications in psychophysiological stress reactivity. @entity2175 ( @entity2175 ) is associated with reduced cardiovascular responses to stress and heightened @entity701 over the day. This study assessed the relationships between optimism, stress responsivity, and daily @entity701 output in @entity1 with @entity2175 . A total of 140 @entity1 with @entity2175 were exposed to laboratory stress. Heart rate (HR), systolic ( @entity13519 ), diastolic blood pressure (DBP), and @entity701 were measured throughout the session. @entity701 output over the day was also assessed. Optimism and self-reported health were measured using the revised Life Orientation Test and the Short Form Health Survey. Optimism was associated with heightened @entity13519 and DBP stress reactivity (ps   <   .047) and lower daily @entity701 output (p   =   .04). Optimism was not related to HR, @entity701 stress responses, or the @entity701 awakening response (ps   >   .180). Low optimism was related to poorer self-reported physical and mental health (ps   <   .01). Optimism could have a protective role in modulating stress-related @entity4148 in @entity1 with @entity2175 .

title: Optimism moderates psychophysiological responses to stress in older XXXX with @entity2175 .

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['T2D', 'Type 2 diabetes']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people']

entities_list: @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic and neuroendocrine dysregulation']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['Cortisol', 'cortisol']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: Several studies have used neuroimaging methods to identify neural change in brain networks associated to emotion regulation after psychotherapy of @entity308 and @entity148 . In the present work we adopted a meta-analytic technique specific to neuroimaging data to evaluate the consistence of empirical findings and assess models of therapy that have been proposed in the literature. Meta-analyses were conducted with the Activation Likelihood Estimation technique, which evaluates the overlap between foci of activation across studies. The analysis included 16 studies found in Pubmed (200 foci of activation and 193 @entity1 ). Separate meta-analyses were conducted on studies of 1) @entity308 , @entity1005 and @entity4697 investigated with rest state metabolism (6 studies, 70 @entity1 ); 2) @entity308 , @entity1005 and @entity4697 investigated with task-related activation studies (5 studies, 65 @entity1 ); 3) the previous studies considered jointly; and 4) phobias investigated with studies on exposure-related activation (5 studies, 57 @entity1 ). Studies on @entity148 and @entity308 gave partially consistent results for changes in the dorsomedial prefrontal cortex and in the posterior cingulated gyrus/precuneus. Several areas of change in the temporal lobes were also observed. Studies on the therapy of @entity913 were consistent with a reduction of activity in medial temporal areas. The cluster of change in the prefrontal cortex may refer to increased recruitment of control processes, as hypothesized by influential models of emotion regulation changes due to psychotherapy. However, not all areas associated with controlled emotion regulation were detected in the meta-analysis, while involvement of midline structures suggested changes in self-related information processing. Changes in @entity913 were consistent with reduced reactivity to phobic stimuli.

title: Neural correlates of psychotherapy in XXXX and @entity308 : a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic disorder']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: Resistance to semi-allogeneic or syngeneic hemopoietic stem cell engraftment can be reduced by treating the unirradiated host with anti-class I MHC antibody. In our previous studies we showed a direct correlation between such resistance and the level of natural suppressor (NS) activity in the host. Thus newborn @entity19 that have high NS activity are very resistant to marrow engraftment, as are adults pretreated with @entity3795 that increases NS activity in the bone marrow. We have now devised a method that allows us to follow hemopoietic engraftment kinetics within the @entity236 itself by assaying individual CFU-granulocyte/macrophage progenitor cells for their host or donor origin over the immediate post-transplant period. By using this method, we find a close correlation between the rate of marrow engraftment and reduction in host NS activity. Marrow engraftment does not correlate with the reduction of either total host bone marrow cellular content or CFU-granulocyte/macrophage progenitor cell levels. NS activity is mediated by @entity3512 -, partially radiosensitive, nylon wool nonadherent cells without NK activity. Adoptively transferred @entity3512 -, irradiated spleen cells containing NS activity induced by pretreatment with @entity3795 delayed engraftment kinetics in the @entity236 . Thus hemopoietic engraftment in the @entity236 appears to be controlled by an inhibitory regulatory activity that is reflected in the in vitro NS assay. These studies suggest new regulatory targets for selective host conditioning to eliminate resistance to marrow transplantation.

title: Host natural suppressor activity regulates hemopoietic engraftment kinetics in antibody-conditioned recipient XXXX .

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['marrow cavity']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: PURPOSE: To report a new surgical procedure for the treatment of ocular surface diseases associated with severe @entity1887 . METHODS: A retrospective review of four @entity1 with severe @entity2194 who required stem cell transplantation and keratoplasty for the correction of limbal insufficiencies. They underwent large diameter lamellar keratoplasty with microkeratome. When @entity409 was associated with limited alteration of the ocular surface and transparent deep corneal stroma only the anterior corneal stroma was transplanted. When the entire corneal thickness was compromised, both anterior and deep donor buttons were transplanted. RESULTS: @entity1 remained stable and improved their visual acuity after surgery. Best-corrected visual acuity ranged from 20/200 to 20/30. No corneal graft rejections were found. The main complication found in one of our @entity1 was a central stromal opacity which required a secondary penetrating keratoplasty. CONCLUSIONS: Automatized large diameter lamellar keratoplasty provides a safe and successful alternative to limbal transplantation for @entity1887 associated with @entity5575 . This technique enables a single-stage surgical procedure and the use of a single donor which reduces the risk of rejection. In addition, better refractive results are achieved due to the quality of the interface and the absence of corneal sutures.

title: Automatized large diameter lamellar keratoplasty and stem cell transplantation for the treatment of ocular surface diseases with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular surface disease']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['limbal insufficiency']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['limbal dysfunction']

entities_list: @entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity']

answer: @entity1887 :: (MESH:D000309,Disease) :: ['limbal insufficiency']


abstract: The @entity460 -binding protein @entity5138 (PV) hallmarks subpopulations of interneurons in the @entity19 brain. We serendipitously observed the de novo expression of PV in ependymal cells of the lateral ventricle wall following in vivo lesioning and brain slicing for the preparation of organotypic hippocampal slice cultures (OHSCs). In OHSCs, de novo PV-expression begins shortly after the onset of culturing, and the number of ependymal cells implicated in this process increases with time. PV-immunopositive ependymal cells aggregate and form compact cell clusters, which are characterized by lumen-formation and beating cilia. Scratches inflicted on such clusters with a sharp knife are rapidly closed. Exposure of OHSCs to NF-  B-inhibitors and to antioxidants reduces PV-expression in ependymal cells, thereby implicating injury-induced @entity32 in this process. Indeed, in vivo stab injury enhances PV-expression in ependymal cells adjacent to the lesion, whereas neuraminidase denudation is without effect. PV-knock-out @entity19 manifest an impaired wound-healing response to in vivo injury, and a reduced scratch-wound reparation capacity in OHSCs. Whole-transcriptome analysis of ependymal-cell clusters in OHSCs revealed down-regulation of genes involved in cytoskeletal rearrangement, cell motility and cell adhesion in PV-knock out @entity19 as compared with wild-type @entity19 . Our data indicate that the injury-triggered up-regulation of PV-expression is mediated by inflammatory cytokines, and promotes the motility and adhesion of ependymal cells, thereby contributing to leakage closure by the re-establishment of a continuous ependymal layer. GLIA 2014.

title: De novo expression of XXXX in ependymal cells in response to brain injury promotes ependymal remodeling and wound repair.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity5138 :: (19293(Tax:10090),Gene) :: ['parvalbumin']


abstract: AIM OF STUDY: Analyze the influence of @entity6 on the prognosis, at short and middle term of @entity1 with non-ST-segment-elevation @entity1187 . @entity1 AND METHOD: We conducted a retrospective review of 308 consecutive medical records of @entity1 admitted to the care unit of our department with a non-ST-segment-elevation @entity1187 . One hundred and fifty-six @entity1 were @entity6 (group 1) and 152 were not (group 2). We compared the demographic, clinical, angiographic and therapeutic characteristics of the two groups and we analyzed the prognosis of @entity6 and non- @entity6 @entity1 at short term (30 days) and at middle term (average: 28 months; extreme: 12 months, 72 months). RESULTS: The mean age was similar into both groups (60.8 years). @entity6 @entity1 were more often @entity1 (42.1% vs 23.1%) and presented a higher prevalence of systemic @entity101 , @entity2299 and family history of @entity453 . Smoking was more frequent in group 2. The rates of coronary angiography, percutaneous transluminal coronary angioplasty, and coronary bypass surgery were similar in the two groups. At 30 days, @entity6 @entity1 were at increased risk for @entity712 (19.1% vs 6.4%) and for major @entity299 (12.5% vs 6.4%). A pejorative prognosis was also observed at middle term among @entity6 @entity1 . They were at greater risk for readmissions for non-ST-segment-elevation @entity1187 (42% vs 25%), for major @entity299 (49.3% vs 31.6%) and for new revascularizations (17.3% vs 7.2%). In a Cox multivariate analysis, @entity6 remains an independent risk factor for major @entity299 at middle term. CONCLUSION: Our study confirms the pejorative prognosis of @entity1187 without ST elevation at short and middle term in @entity6 @entity1 .

title: [Influence of XXXX on the prognosis of non-ST-elevation @entity1187 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome', 'acute coronary syndromes']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['acute heart failure']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetics', 'diabetic', 'diabetes mellitus']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes mellitus']


abstract: BACKGROUND: Anopheles sinensis is a major vector of @entity311 and among the dominant species in Shandong province of China. Insecticide resistance is an important threat to @entity4002 control. However, there are only few reports about insecticide resistance of An. sinensis populations from Shandong province. METHODS: From 2003 to 2012, six districts in Shandong province were selected as the study areas. Insecticide susceptibility bioassay were tested on F1 progeny of An. sinensis to 4% @entity318 , 0.05% @entity316 , 0.15% @entity317 , and 5% @entity2959 , using the standard WHO resistance tube assay. RESULTS: The resistance status of An. sinensis showed a significant decrease in the mortality rates in @entity318 , @entity316 and @entity317 during the past ten years. Whereas obvious increase of mortality to @entity2959 was observed throughout the assay, ranging from 47.37% to 86.62%.

title: Development of insecticide resistance in XXXX vector Anopheles sinensis populations from Shandong province in China.

entities_list: @entity317 :: ('MESH:C052570', 'Chemical') :: ['cyfluthrin']

entities_list: @entity4002 :: ('MESH:D011778', 'Disease') :: ['vector-borne disease']

entities_list: @entity2959 :: ('MESH:D008294', 'Chemical') :: ['malathion']

entities_list: @entity316 :: ('MESH:C017180', 'Chemical') :: ['deltamethrin']

answer: @entity311 :: (MESH:D008288,Disease) :: ['malaria']


abstract: UNASSIGNED: @entity28 during pregnancy has been related with several pathological states in offspring. However, the impact of maternal @entity28 on reproductive system on the progeny is beginning to be elucidated. In this work, we characterize the effect of maternal @entity28 on puberty onset and follicular development in adult offspring in @entity35 . We also propose that alterations in ovarian physiology observed in offspring of @entity28 mothers are due to increased levels of @entity53 during early development. Offspring of control dams and offspring of dams exposed to a @entity1386 ( @entity1386 ) were studied at postnatal days (PND) 1, 7, 14, 30, 60, and 120. Body weight and onset of puberty were measured. Counting of ovarian follicles was performed at PND 60 and 120. Serum @entity53 , @entity11111 , @entity2671 , FSH, LH, and insulin levels were measured by ELISA. Hepatic @entity12284 expression was determined by Western blot. @entity1386 @entity35 had a higher weight than controls at all ages and they also had a precocious puberty. @entity53 levels were increased while @entity12284 expression was reduced from PND 1 until PND 60 in @entity1386 @entity35 compared to controls. @entity11111 was decreased at PND60 in @entity1386 @entity35 . Ovaries from @entity1386 @entity35 had a decrease in antral follicles at PND60 and PND120 and an increase in follicular cysts at PND60 and PND120. In this work, we demonstrated that maternal @entity28 in @entity35 alters follicular development and induces follicular cysts generation in the adult offspring. We observed that maternal @entity28 produces an endocrine disruption through increasing endogenous @entity53 in early life. A programmed failure in hepatic metabolism of @entity53 is probably the cause of its increase.

title: Increase in endogenous @entity53 in the progeny of XXXX @entity35 is associated with precocious puberty and altered follicular development in adulthood.

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'Maternal obesity', 'obesity']

entities_list: @entity11111 :: ('MESH:D004964', 'Chemical') :: ['estriol', 'Estriol']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol', 'Estradiol']

entities_list: @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['HF', 'high-fat diet']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: @entity1 @entity308 and @entity148 show inherited biases across generations, as do antisocial disorders characterized by aggression. Each condition is preceded in @entity1 by behavioral inhibition or @entity146 behavior, respectively, and both are characterized by @entity1172 . In affected families, adults and @entity1 exhibit different forms of altered autonomic nervous system regulation and hypothalamic-pituitary-adrenal activity in response to stress. Because it is difficult to determine mechanisms accounting for these associations, animal studies are useful for studying the fundamental relationships between biological and behavioral traits. Pharmacologic and behavioral studies suggest that @entity1 @entity35 ultrasonic vocalizations (USV) are a measure of an early @entity148 -like state related to separation @entity148 . However, it was not known whether or not early ultrasound emissions in @entity1 @entity35 are markers for genetic risk for @entity148 states later in life. To address these questions, we selectively bred two lines of @entity35 based on high and low rates of USV to isolation at postnatal (P) 10 days of age. To our knowledge, ours is the only laboratory that has ever selectively bred on the basis of an infantile trait related to @entity148 . The High and Low USV lines show two distinct sets of patterns of behavior, physiology and neurochemistry from infancy through adulthood. As adults High line @entity35 demonstrate "anxious"/" @entity308 " phenotypes in behavior and autonomic nervous system (ANS) regulation to standard laboratory tests. In Lows, on the other hand, behavior and autonomic regulation are consistent with an " @entity146 " phenotype. The High and Low USV lines are the first genetic animal models implicating long-term associations of contrasting "coping styles" with early attachment responses. They thus present a potentially powerful model for examining gene-environment interactions in the development of life-long affective regulation.

title: Selective breeding for XXXX @entity35 separation-induced ultrasonic vocalizations: developmental precursors of passive and active coping styles.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Human', 'infant']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressed']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders']

entities_list: @entity1172 :: ('MESH:D001010', 'Disease') :: ['separation anxiety disorders']

answer: @entity1 :: (9606,Species) :: ['infant']


abstract: PURPOSE: We evaluated the association of preoperative serum cell-free circulating DNA concentration in @entity1 with clinically localized @entity263 who underwent radical prostatectomy with @entity1069 ( @entity1069 ) recurrence. EXPERIMENTAL DESIGN: One hundred and ninety-two @entity1 with clinically localized @entity263 , who underwent radical prostatectomy at the Johns Hopkins Hospital and had preoperative serum available for analyses constituted our study population. All serum samples were collected before prostate biopsy or at least 4 months after prostate biopsy. The total amount of serum cell-free circulating DNA from each sample was calculated using a standard curve generated via quantitative real-time PCR. @entity1069 recurrence was defined as a single postoperative @entity1069 level of > or =0.2. The natural logarithm (ln) of the DNA concentration was used for statistical analyses. RESULTS: Of the 192 @entity1 in our study, 56 (29%) experienced @entity1069 recurrence within the study period (median time to @entity1069 recurrence 2 years). The median follow-up time for @entity1 free of disease at last follow-up was 3 years. The median serum cell-free DNA concentration of all @entity1 in the study was 5.3 ng/mL (mean 18.05 ng/mL; range 0.2-320 ng/mL). The mean serum DNA concentration for @entity1 who recurred and for those who did not was 3.8 +/- 34.1 and 13.7 +/- 33.6 ng/mL, respectively (P = 0.001). In a univariate analysis, ln DNA concentration was significantly associated with @entity1069 recurrence (hazard ratio, 1.49; 95% confidence interval, 1.3-1.8; P < 0.001). In the multivariate model, ln DNA concentration was significantly associated with @entity1069 recurrence (hazard ratio, 2.56; 95% confidence interval, 1.1-1.6; P = 0.003). Using bootstrap analyses, serum cell-free DNA concentrations > or =5.75 ng/mL were associated with an increased risk of @entity1069 recurrence within 2 years of radical prostatectomy. CONCLUSION: Our study suggests that preoperative serum cell-free DNA concentration may be a useful prognostic biomarker for @entity1 with clinically localized @entity263 treated with radical prostatectomy.

title: Prognostic value of preoperative serum cell-free circulating DNA in @entity1 with XXXX undergoing radical prostatectomy.

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['PSA', 'prostate-specific antigen']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: BACKGROUND: Biphenotypic @entity3052 is a @entity395 that is difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There is still a lack of studies in @entity8625 in a Chinese population. We present here a comprehensive investigation of the clinical and biological characteristics, and outcome of @entity8625 in our hospital in over a seven year period. DESIGN AND METHODS: We retrospectively analyzed 452 adult @entity3052 @entity1 diagnosed according to French-American-British (FAB) classification and @entity8625 diagnosed according to European Group for the Immunological Characterization of @entity1778 (EGIL) classification, respectively. Biological characteristics, response to treatment, and outcome were examined in @entity8625 @entity1 and compared with that in @entity3052 and @entity981 @entity1 with complete follow-up profiles diagnosed in the same period. RESULTS: Of 452 @entity3052 @entity1 , 21 cases (4.6%) were diagnosed as @entity8625 . Among them, 14 (66.7%) were B lymphoid and myeloid, 5 (23.8%) were T lymphoid and myeloid, one (4.8%) was T/B lymphoid and one (4.8%) was trilineage differentiation. When compared with @entity3052 and @entity981 , @entity1 with @entity8625 showed significantly higher incidence of @entity2280 antigen expression, unfavorable karyotypes, and extramedullary infiltration (p<0.05). In this cohort of @entity1 with @entity8625 , t(9;22) was the most common abnormality in chromosome structure. The median disease-free survival and overall survival in @entity8625 @entity1 was five months and ten months, respectively, significantly shorter than those in @entity3052 and @entity981 @entity1 (p<0.05). CONCLUSIONS: The prognosis of @entity8625 @entity1 is poor when compared with de novo @entity3052 or @entity981 . Biphenotypic @entity3052 @entity1 showed a much higher incidence of @entity2280 antigen expression, complex abnormal karyotype, extramedullary infiltration, relapse, and resistance to therapy after relapse.

title: Clinical and biological characteristics of adult @entity8625 in comparison with that of XXXX and @entity981 : a case series of a Chinese population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'acute leukemia']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['Leukemias']

entities_list: @entity8625 :: ('MESH:D015456', 'Disease') :: ['biphenotypic acute leukemia']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']


abstract: BACKGROUND: Although airbags are a significant development in automobile safety, they have brought with them new medical problems. OBJECTIVE: To describe a case of new-onset @entity565 occurring after exposure to a deployed airbag's contents. METHODS: A 47-year-old @entity1 had a 2.5-year history of chest tightness, @entity393 , and nocturnal and activity-associated cough beginning after a head-on motor vehicle collision when he was driving an automobile equipped with dual driver-passenger airbags. The collision activated both airbags, with the driver's side airbag breaking open, filling the automobile with particulates. The driver remained in the car for 3 minutes and developed acute @entity1353 and chest tightness for the first time in his life. He had a smoking history of 1 pack-year 20 years earlier. Before that time he could exercise frequently, running for 30 minutes almost daily without difficulty. After the collision, he had respiratory symptoms at rest and after exercise, requiring daily control and rescue medication. Subsequently, he developed @entity5143 following exposure to nonspecific agents, which he had never previously experienced. RESULTS: Skin test reactivity was detectable only to dust mite. @entity2710 challenge results were markedly positive at 8 weeks and 2.5 years after the incident. Video laryngoscopy revealed normal vocal cord appearance and function. CONCLUSIONS: Our @entity1 represents the first case, to our knowledge, of new-onset, persistent, irritant-induced @entity565 following airbag deployment. Physicians should be aware of its possibility after airbag exposure, since prompt institution of aggressive therapy may improve @entity1 outcome and dampen or prevent persistent disease.

title: Airbag XXXX : a case report and review of the literature.

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity5143 :: ('MESH:D001986', 'Disease') :: ['bronchospasm']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['decreased exercise tolerance']

entities_list: @entity2710 :: ('MESH:D016210', 'Chemical') :: ['Methacholine']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: OBJECTIVES: This study was undertaken to test the hypotheses that using the atraumatic restorative treatment (ART) approach results in lower @entity1 @entity148 and that lower @entity148 leads to higher restoration/extraction ratios. METHODS: The test group of dental operators (n = 9) was trained in ART The control group (n = 11) was not, and did not apply ART The Short Form of the Dental Subscale of the @entity1 's Fear Survey Schedule (CFSS-SF) and Corah's Dental @entity148 Scale (DAS) were used to assess @entity1 @entity148 after ART (test group) and after traditional restorations (control group). The restoration/extraction ratio calculated for primary ( @entity1 ) and permanent dentitions (adults) per operator was based on 12-month treatment statistics. Dental @entity148 assessments were analysed using ANOVA. Differences were compared using the t-test and corrected for confounding factors (ANCOVA). The Pearson correlation coefficient was used to measure the correlation between @entity148 and restoration/extraction ratios. RESULTS: The mean CFSS-SF score for test-group @entity1 was statistically significantly lower than for the control-group @entity1 . The mean DAS score for test-group adults was statistically significant lower than the control. No significant correlation was observed between dental @entity148 level and restoration/extraction ratio per operator for both dentitions in both groups. CONCLUSION: The first hypothesis was accepted; the second, rejected. Although dental @entity148 scores were lower both in @entity1 and in adult @entity1 treated by ART than in those who received traditional restorative treatments, this positive effect had not resulted in higher restoration/extraction ratios.

title: Atraumatic restorative treatment and dental XXXX in outpatients attending public oral health clinics in South Africa.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient', 'child']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['dental anxiety levels', 'Anxiety', 'anxiety']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: The activation of the @entity172 receptor (ER) from @entity7045 ( @entity7045 )-induced @entity35 @entity5 was studied in vitro. The activation of the receptor induced by heating of the cytosol containing occupied ER was measured by a 3-4-fold increase of receptor binding to nuclei in comparison with the nuclear binding of the nonactivated ER. The activation of the ER was further shown by alteration of the elution profile from @entity8851 -cellulose. A shift of the receptor peak from 234 mM (Peak II, nonactivated ER) to 70 mM (Peak I, activated ER) @entity1391 buffer could be obtained. The overall recoveries of activated ER following chromatography on DEAE-cellulose were significantly lower than the recoveries of the nonactivated ER, 71 and 85%, respectively. Binding of the activated ER to nuclei and chromatography of the supernatant which is not able to bind to nuclei on DEAE-cellulose resulted in a decrease of Peak I and in an increase of the overall recovery. These findings suggest that the nuclear bound ER consists of two parts. One is represented partially by Peak I of the elution profile and the other one by that part of the receptor which can not be eluted from the column under the conditions used. Furthermore, the dissociation of tritiated @entity53 ( @entity57673 ) from the nonactivated ER followed a two component exponential function whereas after activation a monophasic dissociation curve could be observed. The mean half times for the dissociation of @entity57673 from the activated and nonactivated ER were 101 and 7.2 min, respectively. Finally, the nonactivated molybdate stabilized ER sedimented in 5-20% @entity969 density gradients as two peaks, one at 9.5 S and the other at 4 S. After activation of the ER only the smaller 4 S peak was evident. @entity7051 inhibited the activation of the ER measured by nuclear binding assays, @entity969 density gradient analysis, dissociation kinetics or ion exchange chromatography but not completely in every case.

title: Activation of the @entity172 receptor from @entity7045 -induced @entity35 XXXX .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity7045 :: ('CHEBI:50102', 'Chemical') :: ['NMU', 'N-nitrosomethylurea']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['mammary tumors']

entities_list: @entity57673 :: ('p|SUB|E|3|H', 'ProteinMutation') :: ['E3H']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity7051 :: ('MESH:C044659', 'Chemical') :: ['Molybdate']

answer: @entity5 :: (MESH:D009369,Disease) :: ['mammary tumors']


abstract: UNASSIGNED: The @entity31598 (ZIKV) causes @entity4242 and the @entity5011 . Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell @entity1184 , growth restriction, cell-cycle dysregulation, and cell death. We used @entity6739 for the rapid, global functional analysis of the ZIKV genome. All 14 proteins or small peptides were produced under an inducible promoter, and we measured the intracellular localization and the specific effects on ZIKV-associated cytopathic activities of each protein. The subcellular localization of each ZIKV protein was in overall agreement with its predicted protein structure. Five structural and two nonstructural ZIKV proteins showed various levels of cytopathic effects. The expression of these ZIKV proteins restricted cell proliferation, induced @entity1184 , or triggered cellular oxidative stress leading to cell death. The expression of premembrane protein (prM) resulted in cell-cycle G1 accumulation, whereas membrane-anchored capsid (anaC), membrane protein (M), envelope protein (E), and nonstructural protein 4A (NS4A) caused cell-cycle G2/M accumulation. A mechanistic study revealed that NS4A-induced cellular @entity1184 and growth restriction were mediated specifically through the target of @entity3446 (TOR) cellular stress pathway involving Tor1 and type 2A phosphatase activator Tip41. These findings should provide a reference for future research on the prevention and treatment of @entity1800 .

title: Characterization of cytopathic factors through genome-wide analysis of the Zika viral proteins in XXXX .

entities_list: @entity6739 :: ('4896', 'Species') :: ['fission yeast']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['ZIKV diseases']

entities_list: @entity5011 :: ('MESH:D020275', 'Disease') :: ['Guillain-Barr   syndrome']

entities_list: @entity4242 :: ('MESH:D008831', 'Disease') :: ['microcephaly']

answer: @entity6739 :: (4896,Species) :: ['fission yeast']


abstract: The @entity249 ( @entity249 ) has available a multimedia educational program informing physicians, nurse practitioners, clinical staff, and @entity1 about Depo-Provera. It is called "New Developments in Contraception: Depo-Provera". The Upjohn company partially funded the program. It consists of 4 videotapes, 2 brochures, and a reference book on clinical proceedings. " @entity12135 : A New Contraceptive Option" is an 18-minute videotape giving an overview of Depo-Provera for physicians and nurse practitioners. It addresses pharmokinetics, efficacy, safety, side effects, @entity1 selection, administration, and medical management of @entity11796 . " @entity12135 : @entity1 Counseling and Clinical Staff Procedures" is a 15-minute video including @entity1 counseling scenarios and discussion of usual @entity1 questions. Clients can view the "Choosing a Birth Control Method" video to get a balanced overview of 5 reversible contraceptives. It provides graphics, discussions between @entity1 and providers, and @entity1 ' comments on their experiences with the various methods. The fourth video is a Spanish language version of the "Choosing a Birth Control Method" video. One brochure complements the "Choosing a Birth control Method" video; the other one "Questions and Answers About Birth Control Shots", centers on Depo-Provera. @entity249 plans to distribute 55,000 copies of its multimedia educational program to health care professionals and to family planning and Planned Parenthood clinics in the US. This program advances and rounds out @entity249 'S National Program to Prevent Unintended Pregnancy.

title: XXXX launches Depo-Provera education program.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['Association of Reproductive Health Professionals', 'ARHP']

entities_list: @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate']

answer: @entity249 :: (MESH:D007246,Disease) :: ['ARHP']


abstract: BACKGROUND: The prevalence of @entity2023 has doubled in the past two decades. Several studies suggest that up to 50% of adult residents of Mexico City can present manifestations of @entity1576 , and pollens from trees, grasses and weeds are a common cause. To determine the prevalence of their families and antigenic cross-reactivity allows us to offer appropriate diagnoses and treatments. OBJECTIVE: To know the prevalence of sensitization of pollens to trees, grasses and weeds in adults with @entity1576 of the South zone of Mexico City from January 2007 to December 2013. MATERIAL AND METHOD: A cross-sectional, observational and prospective study was done with @entity1 from Mexico City, referred to the National Medical Center Siglo XXI, IMSS, from 2007 to 2013 with a diagnosis of @entity2023 , @entity565 and @entity2024 . We analyzed the results of skin prick tests to pollens from trees, grasses and weeds in selected @entity1 . The results were analyzed using descriptive statistics. RESULTS: A total of 672 @entity1 were analyzed, 70% @entity1 , the average age was 34    16 years. Regarding occupation 31% were students, 48% employees and 21% housewives. Fifty-three percent had @entity2490 , 47% had @entity565 and 40.5% had both, @entity565 and @entity2490 . Prevalence of sensitization to weeds was 56%, 33% to trees and 11% to grasses. CONCLUSIONS: Sensitization to weeds is the first cause of @entity1576 in the south of Mexico City, Amaranthus was the most prevalent pollen in this area. Sensitization to trees is the second cause, with a predominance of trees form Betulaceae, Fagaceae and Oleacea families. Sensitization to grass is the third cause of @entity1576 . The most common are from Pooideae ( @entity5369 ), Chloroideae and Cynodon/Dactylon family.

title: Prevalence of @entity2023 in XXXX with allergic asthma, @entity2490 and @entity2024 in the South of Mexico City 2007-2013.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['pollinosis', 'allergic rhinitis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory pollinosis', 'respiratory allergy']

entities_list: @entity5369 :: ('4522', 'Species') :: ['Lolium perenne']

entities_list: @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: The development of @entity455 in @entity6 involves multifactorial processes. Increased levels of platelets-derived microparticles (PMPs) have been reported in diseases associated with @entity715 risk, but few data are available in @entity6 . We explored the level of PMPs in young @entity1 with type 1 @entity6 in relation to @entity32 , glycemic control, @entity455 and @entity1004 ( @entity1004 ). Eighty @entity1 and adolescents with type 1 @entity6 were divided into two groups according to the presence of @entity455 and compared with 40 healthy controls. @entity1 were subjected to medical history, clinical examination and assessment of high-sensitivity C-reactive protein (hs-CRP), HbA1c, urinary albumin @entity1011 ratio (UACR), flow cytometric analysis for PMPs using anti- @entity1427 and @entity1004 . PMP levels were significantly increased in all @entity1 with type 1 @entity6 (2.92        1.3%) whether with @entity455 (3.46        1.11%) or those without complications (2.37        1.28%) compared with healthy controls (1.28        0.64%; p   <   0.001). @entity1004 was significantly elevated in all @entity1 , and the highest levels were among those with @entity455 (p   <   0.001). Significant positive correlations were found between PMPs and body mass index, HbA1c, serum @entity1011 , total @entity165 , UACR, hs-CRP and @entity1004 (p   <   0.05). Multiple linear regression analysis showed that HbA1c, UACR, hs-CRP and @entity1004 were independently related to PMPs levels in type 1 @entity6 . According to Receiver operating characteristic curve analysis, the cutoff value of PMPs at 2.48% could differentiate @entity1 with and without @entity455 with a sensitivity of 80% and specificity of 73.3%. PMPs are elevated in @entity1 with type 1 @entity6 and can be considered as an early marker of @entity455 and subclinical @entity731 .

title: Platelets microparticles as a link between micro- and macro-angiopathy in young XXXX with type 1 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1004 :: ('MESH:C563733', 'Disease') :: ['carotid intima media thickness', 'CIMT']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['micro-vascular complications', 'vasculopathies']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Bioactivity of Insulin-like growth factors (IGEs) are positively or negatively regulated by IGF binding proteins (IGFBPs). Like IGFs, production of IGFBPs are influenced by a number of hormonal factors. We studied the effects of cytokines on production of IGFBPs in @entity1 fibroblasts in culture. Both @entity1356 and @entity310 inhibited @entity2301 (42/38 KDa species) production in a concentration dependent manner judged by Western ligand blot. Expression of @entity2301 mRNA was also decreased by these cytokines. Moreover, the treatment with @entity1356 and @entity310 resulted in appearance of smaller mol weight (26 KDa) immunoreactive @entity2301 fragment(s) which lacked the ability to bind 125I-IGFs, indicating that these cytokines degrade @entity2301 via activation of proteases. Both @entity1356 and @entity310 decreased production of @entity12561 , whereas they increased that of @entity19518 , @entity650 had little effect on production of IGFBPs. Likewise, @entity379 failed to affect of production of IGFBPs except at high concentrations. The present data demonstrate that cytokines, especially @entity1356 and @entity310 are potent regulators of IGFBPs production and degradation. These cytokines may alter tissue uptake of IGFs and help to counteract the catabolic state induced by them.

title: Effect of cytokines on production of insulin-like growth factor binding proteins (IGFBPs) from XXXX fibroblasts in culture.

entities_list: @entity379 :: ('3458', 'Gene') :: ['interferon-gamma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: R-Ras is a member of the RAS superfamily of small GTP-binding proteins. The physiologic function of R-Ras has not been fully elucidated. We found that R-Ras is expressed by lymphoid and nonlymphoid tissues and drastically up-regulated when bone marrow progenitors are induced to differentiate into dendritic cells (DCs). To address the role of R-Ras in DC functions, we generated a R-Ras-deficient @entity19 . We found that @entity5 induced in @entity58787 (-/-) @entity19 formed with shorter latency and attained greater @entity5 volumes. This finding has prompted the investigation of a role for R-Ras in the immune system. Indeed, @entity58787 (-/-) @entity19 were impaired in their ability to prime allogeneic and antigen-specific T-cell responses. @entity58787 (-/-) DCs expressed lower levels of surface MHC class II and @entity11787 in response to lipopolysaccharide compared with wild-type DCs. This was correlated with a reduced phosphorylation of @entity1995 and @entity1994 . Consistently, R-Ras- @entity3007 level was increased within 10 minutes of lipopolysaccharide stimulation. Furthermore, @entity58787 (-/-) DCs have attenuated capacity to spread on fibronectin and form stable immunologic synapses with T cells. Altogether, these findings provide the first demonstration of a role for R-Ras in cell-mediated immunity and further expand on the complexity of small G-protein signaling in DCs.

title: R-Ras is required for XXXX dendritic cell maturation and CD4+ T-cell priming.

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'mouse strain']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: BACKGROUND: This study reports on a hitherto undescribed @entity74 characterised by @entity154 and @entity154 together with severe @entity16 , @entity410 leading to @entity204 , and the identification of a gene involved in the pathogenesis of the disease. METHODS: Homozygosity mapping was performed using Affymetrix @entity1 Mapping 250k NspI arrays. Sequencing of all coding exons of the candidate genes was performed with primer sets designed using the Primer3 program. Fluorescence activated cell sorting was performed using conjugated antibody to @entity1009 . Staining, acquisition and analysis were performed on a FACSCalibur flow cytometer. RESULTS: Using homozygosity mapping, the study mapped the disease locus to 18q21.32-18q22.1 and identified the disease-causing mutation, @entity60159 ( @entity60160 ), in @entity5416 , which encodes @entity4495 (GPI) @entity2230 transferase 1, a protein involved in GPI-anchor biosynthesis. @entity369 at the position 709 is a highly evolutionarily conserved residue located in the @entity5416 domain. The expression of GPI linked protein @entity1009 on fibroblasts from @entity1 as compared to that in a control individual showed a 10-fold reduction in expression, confirming the pathogenic consequences of the mutation on GPI dependent protein expression. CONCLUSIONS: The abundant expression of @entity5416 in various tissues is compatible with the diverse phenotypic features observed in the @entity1 and with the involvement of multiple body systems. The presence of @entity245 , @entity2421 , and @entity302 combined with @entity154 , @entity10645 , should lead a clinician to suspect a @entity46722 .

title: XXXX is caused by a mutation in @entity5416 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Human', 'patients']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['dysmorphic features', 'multiple congenital anomalies']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['chorea and seizures']

entities_list: @entity10645 :: ('MESH:C567938', 'Disease') :: ['especially anorectal anomalies']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological impairment']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental delay']

entities_list: @entity2230 :: ('MESH:C005448', 'Chemical') :: ['ethanolamine phosphate']

entities_list: @entity46722 :: ('MESH:C537277', 'Disease') :: ['GPI deficiency related disorder']

entities_list: @entity2421 :: ('MESH:D009123', 'Disease') :: ['hypotonia']

entities_list: @entity60160 :: ('p|SUB|R|709|Q', 'ProteinMutation') :: ['p.Arg709Gln']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal recessive syndrome']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity4495 :: ('MESH:D017261', 'Chemical') :: ['glycosylphosphatidylinositol']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['early death']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['Arginine']

answer: @entity410 :: (MESH:D012640,Disease) :: ['Multiple congenital anomalies-hypotonia-seizures syndrome']