abstract: OBJECTIVES: To describe preventive behaviors and behavioral intentions related to @entity791 sexual transmission, other @entity2953 and unwanted pregnancies among 10th grade Barcelona students. DESIGN: Cross-sectional study. Stratified random sample from Barcelona secondary schools in 1996. SETTING: Secondary schools. @entity1 : 981 students at 35 10th grade classrooms. MAIN RESULTS: 82% of the students are 15-16 years old. 58% are @entity1 . 16% have had sexual intercourse ( @entity1 18% and @entity1 14%); among those, 43% of males and 30% of females have had only once sexual intercourse. 78% use always or almost always a condom. 22% of @entity1 and 44% of @entity1 have refused at least an opportunity of unprotected intercourse. @entity1 feel more confident to buy, carry on and use a condom, however @entity1 feel more confident in convincing their partner and refusing unprotected sex. Among those with sexual experience, partner opinion predicts condom use ( @entity1 OR = 30.8 and @entity1 OR = 8.8), as well as partner use ( @entity1 OR = 14.2 and @entity1 OR = 15.4). Intention to use condoms with a regular partner is related to the perception of youth normative behaviors ( @entity1 OR = 10.9 and @entity1 OR = 4.4) and friends opinion ( @entity1 OR = 6.2 and @entity1 OR = 5.4). Condom use with a non regular partner is related also to the perception that its use avoids @entity281 and unwanted pregnancies ( @entity1 OR = 9.9 and @entity1 OR = 8.0). Intention to refuse unprotected sex relates, in both genders, to youth normative behaviors and self-efficacy to refuse unprotected intercourse. CONCLUSIONS: 16% of the 10th grade students have had a sexual intercourse. Only half part of them use always condom, although it is the contraceptive method more frequently used. Condom use relates mainly to partners opinions and their current use. Intentions to use condoms are associated also to friends opinion and youth social norm perception. Intention to use a condom with non regular partners aims avoiding diseases and unwanted pregnancies.

title: [Preventive behaviors for the sexual transmission of XXXX , other @entity281 , and pregnancy in high-school students].

entities_list: @entity1 :: ('9606', 'Species') :: ['Boys', 'girls', 'PARTICIPANTS', 'boys']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity2953 :: ('MESH:D012749', 'Disease') :: ['sexually transmitted diseases']

answer: @entity791 :: (MESH:D000163,Disease) :: ['AIDS']


abstract: Seven @entity1 with high-risk @entity11511 ( @entity11511 ) and six with @entity784 ( @entity784 ) were treated with autologous bone marrow transplantation (ABMT) after in vitro purging of their bone marrow with @entity8587 ( @entity4587 )-ricin A-chain immunotoxin. @entity4587 expression on the @entity5 cells showed large variations between the individual @entity1 and was highly related to the specific cytotoxicity of @entity8587 -ricin A. Incubation of bone marrow with up to 10(-8)mol/L @entity8587 -ricin A in the presence of 6 mmol/L @entity8777 did not compromise the growth potential of the hematopoietic progenitors CFU-GM, CFU-GEMM, and BFU-E. Hematologic engraftment (greater than 10(9) leukocytes/L) occurred within a normal time period (median, 17 days). Seven @entity1 are alive and in complete remission (CR) at 48+, 44+, 40+, 26+, 11+, 7+, and 6+ months after ABMT. Four @entity1 relapsed within 6 months after ABMT. Two of them had the lowest @entity4587 expression on their @entity5 cells, the other two were transplanted in @entity10911 and @entity9637 . Two @entity1 died from transplantation related @entity281 . The immunologic reconstitution was delayed, although the numbers of T cells reached normal levels within 1 month. The number of @entity4587 + cells remained low up to 1 year after transplantation. The T4/T8-ratio was decreased for at least 6 months. The T-cell response to mitogens recovered to normal levels after 1 year. This study shows that ABMT with @entity8587 -ricin A purged bone marrow in high-risk T-cell malignancies results in a complete hematopoietic and a delayed immunologic reconstitution. The actuarial relapse free survival is 61% at 3 years.

title: Autologous transplantation of bone marrow purged in vitro with anti- @entity4587 -( @entity8587 -) ricin A immunotoxin in XXXX and lymphoma.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell lymphoma', 'T-LL']

entities_list: @entity11511 :: ('MESH:D054218', 'Disease') :: ['T-ALL', 'acute T-cell lymphoblastic leukemia']

answer: @entity11511 :: (MESH:D054218,Disease) :: ['T-cell lymphoblastic leukemia']


abstract: 1. The isolated nuclei of the slime mould @entity9417 contain an enzyme that will incorporated [adenine-3H] NAD+ into an acid-insoluble product, which is shown to be @entity12874 . 2. This incorporation has an optimum pH of 8.2 and a temperature optimum below 10degreesC. 3. Optimum stimulation is given by 15 mM-Mg2+. 4. @entity6514 or @entity3902 also stimulates the incorporation, the latter at an optimum concentration of about 1 mM. 5. Under optimum conditions the Km value for the reaction is 0.28 mM at 15degreesC. @entity4571 inhibits the incorporation with a Ki of 5.7 muM. 6. Exogenous DNA stimulates the incorporation by about 100%. 7. Preincubation of the nuclei with deoxyribonuclease, but not with ribonuclease, almost completely inactivates the incorporation of @entity2125 +. 8. The enzyme is unstable at both 0degrees and 15degreesC in the absence of @entity3902 . The presence of @entity3902 at a concentration of 1 mM stabilizes the enzyme at both these temperatures. 9. The activity of this enzyme per nucleus was shown in three separate experiments to fall by about one-half in early S phase and then to rise to its pre-mitotic value after about 3 h, that is in late S phase. 10. The possible physiological function of this enzyme system is discussed.

title: XXXX polymerase in @entity9417 .

entities_list: @entity9417 :: ('5791', 'Species') :: ['Physarum polycephalum']

entities_list: @entity12874 :: ('MESH:D011064', 'Chemical') :: ['poly(ADP-ribose)']

entities_list: @entity3902 :: ('MESH:D004229', 'Chemical') :: ['dithiothreitol']

entities_list: @entity6514 :: ('MESH:D008623', 'Chemical') :: ['2-Mercaptoethanol']

entities_list: @entity4571 :: ('MESH:D009536', 'Chemical') :: ['Nicotinamide']

answer: @entity12874 :: (MESH:D011064,Chemical) :: ['Poly(adenosine diphosphate ribose)']


abstract: @entity1397 , an antiplatelet agent, is increasingly prescribed for @entity1 with @entity64 , @entity583 , @entity1187 , and/or @entity1 post-coronary stent insertion to prevent recurrent @entity65 . Since @entity1397 can increase the risk of @entity360 , co-administration of proton pump inhibitors (PPIs) has been recommended, particularly in @entity1 at high risk. In 2009, the FDA issued warnings about potential interactions between @entity1397 and PPIs, given the fact that both drugs are metabolized via the cytochrome P450 pathway. Prior studies have demonstrated significant reduction in platelet inhibition when PPI therapy is administered to subjects on @entity1397 therapy. Two meta-analyses were published in 2010 and 2011, the first suggesting association of PPIs with adverse @entity65 when observational studies were examined, but noting that the results were limited by the presence of significant heterogeneity. The second meta-analysis did not find a significant increase in the risk of adverse primary events (which included all cause mortality, @entity65 , @entity583 , or @entity64 ), and concluded that analysis of the data from two randomized controlled trials yielded a risk difference of zero. An updated literature search was performed to assess clinical studies describing interactions between PPIs and @entity1397 published from 2011-2012. The majority of these studies did not show significant interactions when primary cardiac outcomes were considered. More importantly, the newer data demonstrated that PPI usage independently was a risk factor for adverse CV outcomes, since most PPI users were older @entity1 who were more likely to have concomitant co-morbid conditions. Two updated reviews also concluded that the presence of confounding factors likely explained differences in results between studies, and that there were no significant differences in effects on @entity1397 between individual proton pump inhibitors. Overall, clinicians can assure their @entity1 that combination therapy is safe when indicated in a @entity1 at high risk of @entity548 , but they should also stop PPI therapy if it is not clinically indicated.

title: Proton pump inhibitors and potential interactions with XXXX : an update.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'recent stroke']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['GI bleeding']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['Clopidogrel', 'clopidogrel']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal hemorrhage']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death', 'cardiovascular events']

answer: @entity1397 :: (MESH:C055162,Chemical) :: ['clopidogrel']


abstract: BACKGROUND: Recently, various surgical approaches to skull base lesions have been developed. Skillful use of the combination of two standard approaches make possible the removal of large @entity75 , which conventionally had been considered inoperative. In this study, we present a case of a @entity1653 located in the cerebellopontine angle and middle cranial fossa. A near total resection was achieved using a combined transpetrosal and fronto-orbito-zygomatic approach. CASE REPORT: A 15-year-old @entity1 presented with a @entity1653 that caused a left @entity393 , @entity4653 , and @entity6447 . Preoperative magnetic resonance imaging revealed a @entity1653 located in the right cerebellopontine angle, middle fossa, and cavernous sinus. The @entity1 underwent a near total resection of the @entity5 through a combined transpetrosal and fronto-orbito-zygomatic approach. He experienced a marked improvement postoperatively and entered high school the following year. CONCLUSIONS: An approach from several angles was necessary for the giant skull based @entity5 presented here. A combination approach was selected for obtaining a wide operative field with minimal brain compression during resection of @entity5 . According to the individual features of each case, selection of the operative approach, decisions regarding the extent of excision, and postoperative treatment regimens should be adequately planned in the preoperative period.

title: Combined transpetrosal and fronto-orbito-zygomatic approach to a giant skull based XXXX : a case report.

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['giant meningioma', 'meningioma']

entities_list: @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar ataxia']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity4653 :: ('MESH:D004401', 'Disease') :: ['dysarthria']

answer: @entity1653 :: (MESH:D008579,Disease) :: ['meningioma']


abstract: OBJECTIVES: This report describes successful anaesthesia and electroconvulsive therapy (ECT) in a @entity1 with an @entity438 . ECT is associated with a hyperdynamic state characterised by arterial @entity101 , @entity591 , and considerably increased cerebral blood flow rate and velocity. These responses pose an increased risk for @entity510 when an @entity438 . METHODS: A 54 year old @entity1 presented for ECT. She had a 20 year history of @entity308 which was unresponsive to three different antidepressant drugs. There was also an unruptured 5 mm saccular @entity439 at the basilar tip, which had been documented by cerebral angiography, but its size had remained unchanged for the previous four years. After she declined surgical intervention, she gave informed consent for ECT. During a series of seven ECT sessions middle cerebral artery flow velocity was recorded by a pulsed transcranial Doppler ultrasonography system. She was pretreated with 50 mg oral @entity2165 daily, continuing up to the day of the last ECT and immediately before each treatment, @entity1854 was infused at a rate of 30 microg/min, to reduce systolic arterial pressure to 90-95 mm Hg. RESULTS: Systolic flow velocity during the awake state ranged from 62-75 cm/s, remaining initially unchanged with @entity1854 infusion. After induction of anaesthesia (0.5 mg/kg @entity3694 and 0.9 mg/kg @entity2900 ), flow velocities decreased to 39-54 cm/s, reaching maximal values of 90 cm/s (only 20% above baseline) after ECT. These flow velocities recorded post-ECT were considerably below the more than twofold increase recorded when no attenuating drugs were used. Systolic arterial blood pressure reached maximal values of 110-140 mm Hg and heart rate did not exceed 66 bpm. Rapid awakening followed each treatment, no focal or global neurological signs were apparent, and the @entity1 was discharged in remission. CONCLUSION: In a @entity1 with @entity308 and a coexisting @entity439 who was treated with ECT, the combination of beta blockade with @entity2165 and intravenous infusion of @entity1854 prevented @entity591 and @entity101 , and greatly attenuated the expected increase in flow velocity in the middle cerebral artery.

title: Intracranial haemodynamics during attenuated responses to electroconvulsive therapy in the presence of an intracerebral XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['major depression']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid haemorrhage']

entities_list: @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm', 'intracerebral saccular aneurysm']

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']

entities_list: @entity2900 :: ('MESH:D013390', 'Chemical') :: ['succinylcholine']

entities_list: @entity3694 :: ('MESH:D008723', 'Chemical') :: ['methohexitone']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysm coexists', 'unruptured basilar artery aneurysm']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysm']


abstract: BACKGROUND: The aim was to examine mortality in @entity146 @entity1 in @entity8928 ( @entity8928 ), over a time period of considerable change in the delivery of mental health services. METHODS: A population-based record linkage analysis was undertaken to quantify mortality among @entity1 with @entity1032 in @entity8928 . Mortality rates were calculated in users of mental health services and compared with rates in the whole population of @entity8928 . Trends in mortality were also examined using relative survival analysis, and proportional hazards regression. RESULTS: The overall mortality rate ratio was 2.57 in males (95% CI: 2.51-2.64), and 2.18 in females (2.12-2.24). The highest cause-specific mortality rate ratio was for deaths due to suicide [RR: 7.37 in males (95% CI: 6.74-8.05) and 8.38 in females (95% CI: 7.11-9.89)], with mortality rate ratios being significantly greater than 1 for all other major causes of @entity204 . A relative survival analysis found that the excess mortality risk was concentrated in the first few years after first contact with mental health services. Proportional hazards regression analysis found a slight elevation of mortality rates over time. CONCLUSIONS: Mortality among @entity146 @entity1 remains high and appears to be increasing. Highest excess mortality rate is associated with suicide, but mortality rates are significantly elevated for all major causes of @entity204 .

title: Mortality in Western Australian XXXX @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness']

entities_list: @entity8928 :: ('MESH:D020241', 'Disease') :: ['Western Australia', 'WA']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: Nine @entity1 with @entity5 stage @entity4888 ( @entity4888 ) have been entered into a pilot study of T-cell depletion and autologous @entity8 ( @entity8 ). Eight @entity1 had detectable rearrangements of the T-cell receptor (TCR) gamma-gene demonstrated by polymerase chain reaction (PCR)/single-stranded conformation polymorphism (SSCP) in the peripheral blood. The median age was 47 years and the median duration of disease before @entity8 was 61 months; Peripheral blood progenitor cells were mobilized using high-dose @entity2879 (1.6 g/m2) and @entity1261 ( @entity1261 ). The apheresis products underwent rigorous T-cell depletion with immunomagnetic methods. Double @entity2280 -positive and @entity404 / @entity405 -negative selection achieved a median reduction of 3.89 log of T cells. All nine @entity1 have been transplanted. Conditioning included @entity3600 (BCNU), @entity2879 and @entity3601 (BEM) in seven @entity1 and total body irradiation plus @entity2879 or @entity3601 in two. Eight @entity1 engrafted promptly and one @entity1 died of @entity295 . All survivors entered complete remission. Seven @entity1 have relapsed at a median of 7 months (2-14) post @entity8 . However, most @entity1 have relapsed into a less @entity146 stage, which has responded to conventional therapy. Four out of seven evaluable @entity1 had detectable TCR rearrangements in the T-cell depleted graft. A T-cell clone was also detected in the peripheral blood before relapse in four cases. Autologous @entity8 is feasible, safe and can result in complete remission in a significant proportion of @entity1 with @entity5 stage @entity4888 . Despite a short relapse-free survival, most @entity1 achieved @entity66 control at the time of relapse.

title: T-cell depletion and autologous @entity8 in the management of @entity5 stage XXXX with peripheral blood involvement.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4888 :: ('MESH:D009182', 'Disease') :: ['mycosis fungoides', 'MF']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['septicaemia']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['G-CSF', 'granulocyte colony-stimulating factor']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['good disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity3601 :: ('MESH:D008558', 'Chemical') :: ['melphalan']

entities_list: @entity3600 :: ('MESH:D002330', 'Chemical') :: ['carmustine']

answer: @entity4888 :: (MESH:D009182,Disease) :: ['mycosis fungoides']


abstract: CONTEXT: Few studies have evaluated the relationship between fruit and vegetable intake and @entity65 . OBJECTIVE: To examine the associations between fruit and vegetable intake and @entity385 . DESIGN, SETTING, AND SUBJECTS: Prospective cohort studies, including 75 596 @entity1 aged 34 to 59 years in the Nurses' Health Study with 14 years of follow-up (1980-1994), and 38683 @entity1 aged 40 to 75 years in the Health Professionals' Follow-up Study with 8 years of follow-up (1986-1994). All individuals were free of @entity65 , @entity5 , and @entity6 at baseline. MAIN OUTCOME MEASURE: Incidence of @entity385 by quintile of fruit and vegetable intake. RESULTS: A total of 366 @entity1 and 204 @entity1 had an @entity385 . After controlling for standard cardiovascular risk factors, @entity1 in the highest quintile of fruit and vegetable intake (median of 5.1 servings per day among @entity1 and 5.8 servings per day among @entity1 ) had a relative risk (RR) of 0.69 (95% confidence interval [CI], 0.52-0.92) compared with those in the lowest quintile. An increment of 1 serving per day of fruits or vegetables was associated with a 6% lower risk of @entity385 (RR, 0.94; 95 % CI, 0.90-0.99; P =.01, test for trend). Cruciferous vegetables (RR, 0.68 for an increment of 1 serving per day; 95% CI, 0.49-0.94), green leafy vegetables (RR, 0.79; 95% CI, 0.62-0.99), citrus fruit including juice (RR, 0.81; 95% CI, 0.68-0.96), and citrus fruit juice (RR, 0.75; 95% CI, 0.61-0.93) contributed most to the apparent protective effect of total fruits and vegetables. Legumes or @entity415 were not associated with lower @entity385 risk. The multivariate pooled RR for total @entity64 was 0.96 (95% CI, 0.93-1.00) for each increment of 2 servings per day. CONCLUSIONS: These data support a protective relationship between consumption of fruit and vegetables-particularly cruciferous and green leafy vegetables and citrus fruit and juice-and @entity385 risk.

title: Fruit and vegetable intake in relation to risk of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'persons', 'men']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: @entity1 with thyrotropin-secreting @entity977 may present with mass effect, @entity4614 , and/or @entity1378 . The spectrum of pathologic and clinical features of @entity1 whose @entity5 demonstrate b-thyrotropin immunoreactivity (b-TSH IR) has not been characterized. To characterize the phenotype of @entity1 with @entity977 with positive b-TSH IR, we conducted a retrospective analysis of @entity1 records of all adult @entity1 (n = 1,223) undergoing pituitary surgery in our institution over one decade (1999-2009). The search identified 166 adults with @entity5 which had b-TSH IR. These @entity1 were individually matched to 166 @entity1 whose @entity5 revealed no b-TSH IR. Clinical, pathological, imaging and biochemical data were extracted. 332 @entity1 , aged 51.4    15.1 years [150 @entity1 (45 %) and 182 @entity1 (55 %)], with @entity977 (mean @entity5 diameter    SD: 22.7    9.0 mm) were studied. The degree of b-TSH IR was associated with the presence of central @entity1378 (p < 0.0001) or @entity5651 (p = 0.0217). @entity1 whose @entity5 expressed more extensive b-TSH IR were less likely to develop @entity2894 than those without b-TSH IR (p = 0.0428). In addition, the degree of b-TSH IR correlated with the presence of immunoreactivity for b-FSH (p < 0.0001), b-LH (p < 0.0001), alpha subunit (p < 0.0001), and GH (p = 0.0036). CONCLUSIONS: Pituitary adenomas expressing b-TSH IR were more likely to demonstrate immunoreactivity for b-FSH, b-LH, GH or alpha subunit. @entity1 with @entity5 were more likely to exhibit @entity1378 and @entity5651 , but less likely to develop @entity2894 than @entity1 without b-TSH IR. These findings suggest that b-TSH IR is associated with specific phenotypic features in @entity1 with @entity977 .

title: Pathologic and clinical features of XXXX showing TSH immunoreactivity.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'such tumors', 'tumors']

entities_list: @entity2894 :: ('MESH:D010899', 'Disease') :: ['pituitary apoplexy']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism']

entities_list: @entity4614 :: ('MESH:D007018', 'Disease') :: ['hypopituitarism']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas']

answer: @entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']


abstract: AIM: To investigate whether activated @entity505 nanoparticles suspension (ACNS) or @entity6693 (MB) can increase the detected number of lymph nodes in @entity14 . METHODS: Sixty-seven of 72 @entity14 @entity1 treated at our hospital fulfilled the inclusion criteria of the study which was conducted from December 2010 to February 2012. Seven @entity1 refused to participate. Eventually, 60 @entity1 were included, and randomly assigned to three groups (20 in each group): ACNS group (group A), MB group (group B) and non-stained conventional surgical group (group C). In group A, @entity1 received subserosal injection of 1 mL ACNS in a 4-quadrant region around the mass. In group B, the main artery of specimen was identified and isolated after the specimen was removed, and 2 mL MB was slowly injected into the isolated, stretched and fixed vessel. In group C, no ACNS and MB were injected. All the mesentery lymph nodes were isolated and removed systematically by visually inspecting and palpating the adipose tissue. RESULTS: No difference was observed among the three groups in age, gender, @entity5 location, @entity5 diameter, T-stage, degree of @entity260 and peritoneal drainage retention time. The total number of detected lymph nodes was 535, 476 and 223 in the three groups, respectively. The mean number of detected lymph nodes per @entity1 was significantly higher in group A than in group C (26.8    8.4 vs 12.2    3.2, P < 0.001). Similarly, there were significantly more lymph nodes detected in group B than in group C (23.8    6.9 vs 12.2    3.2, P < 0.001). However, there was no significant difference between group A and group B. There were 50, 46 and 32 metastatic lymph nodes dissected in 13 @entity1 of group A, 10 @entity1 of group B and 11 @entity1 of group C, without significant differences among the three groups. Eleven of the 60 @entity1 had insufficient number of detected lymph nodes (< 12). Only one @entity1 with T(4a) @entity5 had 10 lymph nodes detected in group B, the other 10 @entity1 were all from group C. Based on the different diameter categories, the number of detected lymph nodes in groups A and B was significantly higher than in group C. However, there was no statistically significant difference between group A and group B. The metastatic lymph nodes were not significant different among the three groups. Similarly, @entity5 location, T stage and @entity5 differentiation did not affect the staining results. Body mass index was a minor influencing factor in the two different staining methods. The stained lymph nodes can easily be identified from the mesenteric adipose tissues, and the staining time for lymph nodes was not significantly different compared with unstained group. None of the @entity1 in groups A and B had drug-related complications. CONCLUSION: Both activated @entity505 nanoparticles suspension in vivo and @entity6693 in vitro can be used as tracers to increase the detected number of lymph nodes in @entity14 .

title: @entity14 lymph node staining by activated @entity505 nanoparticles suspension in vivo or XXXX in vitro.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer']

entities_list: @entity6693 :: ('MESH:D008751', 'Chemical') :: ['methylene blue']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['differentiation, postoperative complications']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity6693 :: (MESH:D008751,Chemical) :: ['methylene blue']


abstract: BACKGROUND: The pathogenesis of @entity1109 in @entity1 with @entity2210 ( @entity2210 ) is still unclear. The water loading test (WLT) is a new method for evaluation of gastric function. Our aim was to determine the impact of sex, age and psychological factors on the results of WLT in @entity2210 @entity1 , @entity2210 -subgroups and healthy controls (HCs), and to evaluate the safety of the test. METHODS: Fifty-six HCs and 35 consecutive @entity1 with @entity2210 drank mineral water (100 ml/min) until intolerable. Serum samples for @entity1372 , @entity972 and @entity1011 was taken before and after drinking. Water quantity was registered and symptoms were assessed after maximal water intake and 30 min later using a VAS scale. @entity1 also completed questionnaires measuring psychological general well-being (PGWB) and @entity344 (GSRS and Mearin score). RESULTS: Healthy @entity1 drank more than healthy @entity1 , 2350 +/- 105 ml versus 1860 +/- 100 ml (P < 0.01), and the same gender difference was noted in @entity2210 @entity1 , 1770 +/- 115 ml versus 1180 +/- 110 ml (P < 0.01). Maximal water intake was significantly higher in HC than in @entity2210 @entity1 , both in males (P < 0.001) and females (P < 0.0001). Age had no impact on drinking capacity. @entity2210 @entity1 had more symptoms 30 min after maximal water intake than HCs. Serum @entity1372 decreased from 141 +/- 0.3 mmol/l to 138 +/- 0.5 mmol/l. Two of the assessed psychological factors, general health and depressed mood, correlated with water intake in @entity2210 @entity1 (Rho = 0.47, P < 0.01 respectively Rho = 0.41, P < 0.05). CONCLUSION: WLT is a useful, simple and safe test for evaluating symptoms in @entity2210 @entity1 . Sex, but not age affects the results of the WLT. Furthermore, psychological factors must also be taken into consideration when interpreting the WLT.

title: Impact of sex and psychological factors on the water loading test in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Participants', 'men']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['upper abdominal symptoms']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['functional dyspepsia', 'FD']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity2210 :: (MESH:D004415,Disease) :: ['functional dyspepsia']


abstract: The aim of the current study was to gather information about time and etiology of @entity2524 , and to analyze the reasons for treatment needs with a questionnaire used among edentulous @entity1 . 60 @entity1 (age 44-98 years) who requested dental treatment were included. More than half of the @entity1 were edentulous before the age of 60, in almost all cases the maxilla was affected first. This difference was more pronounced in @entity1 , who experienced @entity2524 in the maxilla 17 years prior to the mandible. At the time of edentulism @entity1 were about ten years younger than @entity1 . According to @entity1 'report, periodontal disease was the most common reason for @entity2524 . In the mandible, prosthesis retention was influenced by alveolar ridge resorption, while in the maxilla there was no relation between the amount of resorption and perceived retention. This indicates that maxillary prostheses retention is influenced by other factors besides the alveolar ridge morphology. So, permanent intake of drugs potentially causing @entity2133 was related to poorer assessment of prostheses retention in the upper jaw. The results of the questionnaire " @entity1 satisfaction related to prosthetic restoration" before treatment indicated that the general satisfaction with the existing complete denture in the mandible was influenced by functional problems and the impairment of @entity1 'self-confidence (R-squared = 0.754). The main reason for requesting treatment was the poor retention of the lower denture. More than half of the @entity1 stated that they refrained from eating certain foods due to a reduced chewing ability.

title: [Survey of treatment-seeking complete denture wearers concerning XXXX , retention behavior and treatment expectations].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'Patient', 'men']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia']

entities_list: @entity2524 :: ('MESH:D016388', 'Disease') :: ['tooth loss']

answer: @entity2524 :: (MESH:D016388,Disease) :: ['tooth loss']


abstract: BACKGROUND: Studies of @entity4269 have used inconsistent measures and criteria. The purpose of this pilot study was to measure the onset and incidence of acute @entity4269 in @entity0 survivors using strict criteria for limb evaluation. MATERIALS AND METHODS: Eligible @entity1 were those undergoing @entity0 surgery that included axillary staging and/or radiation therapy of the breast. Arm volume, strength, and flexibility were measured preoperatively and quarterly. @entity4269 was defined as a greater than 10% increase in limb volume. Additional strength and flexibility assessments were done at these times. RESULTS: In 30 evaluable @entity1 , half underwent modified radical mastectomy and half lumpectomy, with half of the lumpectomy @entity1 undergoing axillary node staging. Of the 30 @entity1 27% were Stage 0; the rest were Stage I (27%), IIA (13%), IIB (23%), and IIIA (7%). One subject was IIIB postoperatively. There were 2 @entity1 with a 10% or greater change in limb volume; the change was detected in one @entity1 at 3 months (5% incidence) and in the second @entity1 at 6 months (11% incidence). Both had undergone mastectomy and axillary dissection and one of these two @entity1 had symptoms of tingling and @entity1183 in the affected arm that began at 3 months. Overall, 35% of the sample experienced symptoms by 3 months, which included @entity1183 , @entity158 , but without volume changes. The relationship between undergoing modified radical mastectomy and experiencing symptoms in the affected limb at 3 months was significant (P = 0.05). CONCLUSIONS: In this interim report strict methods of measurement and limb volume comparisons detected acute @entity4269 at 3 months in 5% of the sample, and at 6 months in 11% of the sample. Furthermore, symptoms were detected in 35% without volume changes at 3 months postoperatively, which may warn of @entity4269 occurrence within the next 3 months. This may assist clinical evaluation of symptoms in the postoperative period and support early referral to @entity4269 experts.

title: Surgical outcomes after XXXX surgery: measuring acute @entity4269 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['Lymphedema', 'lymphedema']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['aching, and tingling of the entire upper extremity']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: AIMS: @entity859 is a possible mediator in @entity907 ( @entity907 ) via the activation of its receptors. High expression of @entity859 A2A receptors ( @entity28569 ) has been reported in @entity907 . The function of these over-expressed receptors in this population has never been evaluated. METHODS AND RESULTS: We used Adonis, a specific-made antibody with @entity28569 agonist properties, to evaluate binding parameters (i.e. dissociation constant @entity573 ) and @entity268 production (i.e. EC50) by peripheral blood mononuclear cells of 16 @entity907 @entity1 . Eight healthy volunteers served as controls. @entity28569 expression was higher in @entity1 than controls; mean: 11.5    1.2 vs. 7.7    0.8 @entity10058 , P = 0.04. Also, @entity573 values were higher in @entity1 than controls: 2.1    0.02   10(-7) vs. 5    1   10(-8) M, P < 0.01 In controls, @entity573 values were lower than EC50 (5    1.7   10(-8) vs. 2.8    0.4 10(-7) M, P < 0.01), but in @entity1 , @entity573 values did not differ from EC50: 2.    0.2   10(-7) vs. 2.5    0.4   10(-7) M, P > 0.05. However, four @entity1 had lower EC50 (3.5    0.3   10(-8) M) than @entity573 (2.9    1.2   10(-7) M; @entity573 /EC50 = 9.6), suggesting the presence of spare receptors. CONCLUSION: The function of @entity28569 of @entity1 with @entity907 was preserved since their stimulation by Adonis led to @entity268 production with an EC50 comparable with those in controls. However, their affinity was lower than those of controls. Our results suggest that @entity28569 are implicated in the physiopathology of @entity907 .

title: A2A XXXX receptor function in @entity1 with @entity907 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine']

entities_list: @entity907 :: ('MESH:D019462', 'Disease') :: ['vasovagal syncope', 'VVS']

answer: @entity859 :: (MESH:D000241,Chemical) :: ['adenosine']


abstract: PURPOSE: We objectively compare the costs associated with the medical and surgical treatment of @entity263 . MATERIALS AND METHODS: We analyzed and compared itemized billing statements for 28 @entity1 with metastatic @entity263 . Half of the @entity1 were treated medically with the luteinizing hormone-releasing hormone analogue @entity3086 , while the other half underwent bilateral therapeutic orchiectomy. In addition, differences in hospital cost to treat these @entity1 were calculated. RESULTS: During a mean followup of 24 months @entity3086 treated @entity1 were charged  500.00 per month of treatment compared to average monthly expenditure of  226.00 for orchiectomy @entity1 during a 23-month interval. By 9 months charges incurred by both groups were equal and by 20 months medically treated @entity1 accumulated urological charges twice that of the surgically treated @entity1 . The true hospital cost to treat these @entity1 followed the same trend, that is the medically treated group cost twice as much to treat by 15 months. For the average stage D2 case @entity3086 therapy charges were  9,420, or 63%, more than orchiectomy. Similarly, @entity3086 cost the hospital  8,924 more than surgery. CONCLUSIONS: Medical management of @entity263 is expensive. With broadening applications and @entity342 deprivation being initiated earlier in the course of disease, the amount spent on medical therapy will continue to escalate. For @entity1 with a life expectancy of more than 9 months orchiectomy is the most cost-effective treatment option.

title: Cost comparison of orchiectomy and XXXX in @entity263 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity3086 :: ('MESH:D016729', 'Chemical') :: ['leuprolide']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['adenocarcinoma of the prostate', 'metastatic prostate cancer']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity3086 :: (MESH:D016729,Chemical) :: ['leuprolide']


abstract: PURPOSE: We used quantitative parameters of renal sonography to differentiate @entity1 with significant obstruction requiring surgical intervention from those without significant obstruction who were followed conservatively. MATERIALS AND METHODS: We retrospectively reviewed the records of @entity1 who underwent evaluation for @entity3041 . Those with a history of vesicoureteral reflux, anatomical @entity1494 were excluded from study. @entity1 were divided according to @entity3041 grade into groups 1-grades III and IV followed conservatively, 2-grades III and IV requiring surgical intervention, 3-unilateral grade II and 4-bilateral. All images were scanned into a computer. Renal parenchymal and pelvic area was determined using National Institutes of Health image software. Parenchymal-to-pelvic area ratios were calculated from all images. We evaluated the ability of these measurements to determine the likelihood of surgical intervention. RESULTS: The records of 81 @entity1 were available for analysis. Deterioration in parenchymal area growth was a predictor of surgical intervention. Such @entity1 had catch-up growth of the affected kidney after pyeloplasty. A parenchymal-to-pelvic area ratio of greater than 1.6 on the initial ultrasound study after birth predicted cases that would need pyeloplasty in the future (p <0.05). No @entity1 with grade II @entity3041 required surgical intervention. CONCLUSIONS: Following serial parenchymal area on serial ultrasound is useful for evaluating @entity1 with @entity3041 . Those with a parenchymal area below the nomogram for growth usually require pyeloplasty. A parenchymal-to-pelvic area ratio of less than 1.6 on the initial ultrasound study after birth in @entity1 with prenatally diagnosed @entity4145 or on initial ultrasound in those diagnosed postnatally indicated the need for surgical intervention in this limited series.

title: Evaluation of sonographic renal parenchymal area in the management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['abnormalities or neurogenic bladder']

entities_list: @entity4145 :: ('MESH:C537373', 'Disease') :: ['ureteropelvic junction obstruction']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

answer: @entity3041 :: (MESH:D006869,Disease) :: ['hydronephrosis']


abstract: OBJECTIVE: The purpose of this study was to determine whether a relationship exists between CT-detected @entity730 in the main renal artery and @entity2791 . We also evaluated whether @entity729 are more indicative of @entity850 in particular @entity1 subgroups based on age, sex, or @entity101 status. MATERIALS AND METHODS: We retrospectively reviewed the examinations of 70 @entity1 (122 kidneys) undergoing both abdominal CT and angiography for various clinical conditions, most commonly evaluation of a @entity5 or @entity439 . CT studies were evaluated for degree of @entity730 at the orifice and in the proximal and distal segments of the main renal artery. The angiograms were evaluated for degree of @entity543 . @entity2791 was defined as a reduction in cross-sectional area of 75% or more. A separate analysis was performed on male and female @entity1 above and below 65 years of age, with and without @entity101 . RESULTS: Renal arteries with clumps of @entity460 (> 3 mm in diameter) had a higher percentage of @entity850 (7/16, 44%) than did renal arteries with less @entity460 (16/53, 30%), and renal arteries with no @entity460 had the fewest stenoses (9/53, 17%; p = .02). Calcifications in the renal artery were not good predictors of @entity850 as they were frequently seen in arteries with nonsignificant @entity543 and were occasionally seen in arteries with no @entity543 . The @entity1 's sex was not a significant factor in this analysis (p = .34). @entity729 in @entity101 @entity1 showed a stronger association with @entity2791 , but the overall ability to predict @entity850 remained poor. However, @entity730 may be significant in @entity1 less than 65 years old, in whom this finding was associated with @entity850 all three cases (100%). Similar @entity730 in @entity1 65 years old or more were associated with @entity850 in only 4 (31%) of 13 cases (p < .01). CONCLUSION: CT-detected @entity730 in renal arteries are associated with @entity850 , but their predictive value in the general population or in @entity101 @entity1 is poor. These @entity730 in a @entity1 less than 65 years of age are a better indicator of @entity2791 .

title: CT-detected renal arterial @entity730 : correlation with XXXX on angiography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'persons']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['Renal artery stenosis', 'stenosis of the renal artery', 'renal artery stenosis']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification', 'calcifications']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['renal artery calcifications', 'Renal artery calcifications']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['narrowing']

answer: @entity2791 :: (MESH:D012078,Disease) :: ['renal artery stenosis']


abstract: Among other symptoms, @entity15 can also produce symptoms of affective and @entity73 . The majority of @entity1 have certain @entity73 , and the' most common @entity1316 is @entity308 . The aim of the study was to determine the correlation of the Mini-Mental State (MMS) and Beck Depression Inventory (BDI) scale scores with the Expanded Disability Status Scale (EDSS) score in @entity1 with @entity15 treated at University Department of Neurology, Sarajevo University Clinical Center in Sarajevo. We evaluated 50 randomly selected @entity1 with various types of @entity15 using the MMS, BDI and EDSS instruments. The study included 33 @entity1 and 17 @entity1 (66% : 34%), mean age 40.74 years (SD 9.236). The mean value of EDSS score was 3.98, ranging from 1.0 to 8.5 in @entity1 and from 1.0 to 6.5 in @entity1 . BDI scale scores showed a mean value of 12.56. The mean MMS score in baseline sample was 26.88. Statistically significant positive correlation was found between age and EDSS score, and negative correlation between EDSS and @entity10843 , as well as between BDI and MMS. Study results indicated older @entity1 with @entity15 to have a higher EDSS score with more pronounced cognitive disturbances. There was no statistically significant correlation between EDSS score and @entity308 .

title: Cognitive and @entity308 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'reactive depression']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunctions', 'cognitive disorders']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['affective disorder']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

answer: @entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']


abstract: BACKGROUND. At the current time, the belief that @entity348 ( @entity348 ) offers a better survival benefit compared with distal gastrectomy (DG) in distal @entity356 still persists among many surgeons. The aim of the study was to determine whether @entity348 in @entity1 with distal @entity5 offers a benefit in long term survival compared with DG. METHODS. Data on 180 consecutive @entity1 with @entity420 of the distal stomach that underwent surgery during the period 2000-2003 were analyzed. Distal gastrectomy was performed on 91 @entity1 (50.5%), and 89 @entity1 (49.5%) underwent @entity348 . RESULTS. The postoperative morbidity ( @entity834 , intraperitoneal @entity548 and @entity358 ) was significantly higher in the @entity348 group than in the DG group. The @entity348 group had a significantly higher rate of 30-day postoperative mortality than DG group, and a longer mean postoperative hospital stay. The 5-year survival rate was significantly higher for the DG group than for the @entity348 group. The number of lymph node @entity3 and TNM stages are significant predictors of poor survival. CONCLUSIONS. Compared with @entity1 undergoing @entity348 , a better long-term survival time, lower postoperative morbidity and mortality rates and a lower hospitalization stay was obtained in @entity1 that underwent DG for distal @entity356 . This observation justifies the use of this procedure for the surgical therapy of the @entity5 of distal stomach.

title: Long term outcome following surgical treatment for distal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leakage']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'stomach cancer']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['total gastrectomy', 'TG']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: UNASSIGNED: We report the unique case of late-onset pancraniosynostosis presenting with rapid @entity227 , without other symptoms of @entity428 . A 10-year-old @entity1 had @entity227 for 1 month. Magnetic resonance imaging (MRI) demonstrated a borderline @entity1645 . Ophthalmologic exam confirmed @entity1829 and decreased visual acuity. Opening pressure on lumbar puncture was 55 mmH2O. The @entity1 was diagnosed with @entity6437 cerebri and prescribed Diamox. Four days later, she re-presented with worsening vision and increased @entity1829 and was taken for emergent ventriculo-peritoneal shunt placement. A postoperative computed tomographic scan showed the absence of all cranial sutures. Vision had not improved. A cranial vault expansion and optic nerve fenestration was performed. Pancraniosynostosis must be considered in a @entity1 with rapid @entity227 and @entity428 , or with the presumptive diagnosis of @entity6437 cerebri. Assurance of normal cranial suture anatomy by computed tomographic scan is imperative in @entity1 with an atypical presentation of @entity6437 cerebri.

title: Blindness From Late Presenting Undiagnosed XXXX Cerebri.

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients', 'patient', 'child']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual deterioration', 'episodes of blurry vision']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure']

entities_list: @entity6437 :: ('MESH:D006104', 'Disease') :: ['pseudotumor']

entities_list: @entity1645 :: ('MESH:D001139', 'Disease') :: ['Chiari I malformation']

entities_list: @entity1829 :: ('MESH:D010211', 'Disease') :: ['papilledema']

answer: @entity6437 :: (MESH:D006104,Disease) :: ['Pancraniosynostosis Mimicking Pseudotumor']


abstract: AIMS: The aim of this work was to demonstrate that strains of @entity1336 may be able to produce @entity7224 and @entity5261 from one of the major @entity1522 present in fruit juices and wine, @entity369 , and from @entity535 -derived @entity7222 . METHODS AND RESULTS: Biogenic @entity4478 were determined by HPLC. Their production in the culture medium was similar under both microaerophilic and anaerobic conditions. The presence of @entity3281 had a minimal influence on the results, whereas the addition of @entity2707 increased @entity6115 production 10-fold. @entity1336 hilgardii X1B, isolated from wine, was able to degrade @entity369 by two pathways: @entity369 deiminase and @entity369 decarboxylase. The isolate was able to produce @entity7224 from @entity7222 and from @entity5261 . @entity1336 strains N4 and N8, isolated from orange, utilized @entity369 via the @entity369 deiminase system. Only the N4 strain was able to produce @entity7224 from @entity7222 . CONCLUSION: It has been demonstrated that Lact. hilgardii X1B is able to produce the most important biogenic @entity6115 found in wine, @entity7224 , and also @entity5261 from @entity369 and @entity7222 , and that @entity1336 , considered to be an innocuous spoilage micro-organism in fruit juices, is able to produce @entity4478 . SIGNIFICANCE AND IMPACT OF THE STUDY: The results have significance in relation to @entity6766 caused by beverages that have been contaminated with biogenic @entity4478 .

title: Biogenic XXXX production by @entity1336 .

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity6766 :: ('MESH:D005517', 'Disease') :: ['food poisoning']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity2707 :: ('MESH:D011732', 'Chemical') :: ['pyridoxal phosphate']

entities_list: @entity7222 :: ('CHEBI:18257', 'Chemical') :: ['ornithine']

entities_list: @entity7224 :: ('MESH:D011700', 'Chemical') :: ['putrescine']

entities_list: @entity5261 :: ('MESH:D000376', 'Chemical') :: ['agmatine']

entities_list: @entity1336 :: ('1590', 'Species') :: ['Lactobacillus', 'Lactobacillus plantarum']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity6115 :: (CHEBI:32952,Chemical) :: ['amine']


abstract: BACKGROUND: High-intensity focused ultrasound (HIFU) has been shown to control bleeding from liver incisions, and blood vessel punctures and incisions. The objective of the current study was to investigate the capability of HIFU to stop bleeding from @entity130 in a @entity1707 model. METHODS: Surgical incisions, 25 to 50 mm in length and 2 to 8 mm in depth, were made in the spleens of five anesthetized @entity1707 . HIFU with a frequency of 5 MHz was applied within 5 seconds of making the incision. A total of 39 incisions and HIFU treatments were performed. RESULTS: Bleeding from all incisions was stopped completely after HIFU treatment. The average times to control and completely arrest the @entity548 were 28 and 55 seconds, respectively. The mechanisms of hemostasis appeared to be thermally induced coagulation @entity39 of @entity4558 tissue and occlusion of blood vessels by a mechanically induced homogenized @entity4558 tissue. CONCLUSION: HIFU may provide a useful method of hemostasis for actively bleeding spleen. Because of its ability to induce hemostasis at adjustable depth, HIFU may prove to be a useful cauterization method both in the operating room and for @entity1 who are managed nonoperatively.

title: Control of XXXX by using high intensity ultrasound.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['splenic injuries']

answer: @entity548 :: (MESH:D006470,Disease) :: ['splenic bleeding']


abstract: OBJECTIVE: To explore specific clinical issues, surgical results, and complications of 80 cochlear implantations (CI) in 55 @entity1 with @entity18260 ( @entity18260 ) or @entity8468 ( @entity8468 ). BACKGROUND: Previous studies have focused either on unselected case series or on populations with @entity600 . @entity18260 / @entity8468 accounts for up to 10% of congenital SNHL, rendering this a large group of cochlear implant candidates. The abnormal inner ear anatomy of these @entity1 may be associated with a lower surgical success rate and a higher rate of complications. STUDY DESIGN: Retrospective review of @entity1 ' medical records and CT/MRI. SETTING: Tertiary referral center. MATERIALS AND METHODS: The medical records and CT/MRI images of 55   @entity18260 / @entity8468 @entity1 receiving 80 cochlear implantations from 1982-2014 were reviewed. Demographic data, surgical results, intra-operative incidents, and post-operative complications were retrieved. RESULTS: Complications occurred in 36% of implantations; 5% hereof major complications. Gushing/oozing from the cochleostoma occurred in 10% of implantations and was related to transient, but not prolonged post-operative vertigo. CONCLUSION: Intra-operative risks of gushing/oozing and post-operative vertigo are the primary clinical issues in @entity18260 / @entity8468 @entity1 regarding CI. Nonetheless, the surgical success rate is high and the major complication rate is low; similar to studies of unselected series of CI recipients.

title: Cochlear implantation in XXXX and @entity8468 - clinical challenges, surgical results, and complications.

entities_list: @entity18260 :: ('MESH:C536648', 'Disease') :: ['PS', 'Pendred syndrome']

entities_list: @entity8468 :: ('OMIM:600791', 'Disease') :: ['NSEVA', 'non-syndromic enlarged vestibular aqueduct']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['mixed cochlear malformations']

answer: @entity18260 :: (MESH:C536648,Disease) :: ['Pendred syndrome']


abstract: OBJECTIVES: Thymectomy is a surgical treatment of @entity1737 . Our goal is to report our experience in the surgical treatment of @entity1737 with or without @entity704 and a review of the literature. MATERIALS AND METHODS: This is a retrospective study over a period of 10 years (2001-2010) on 43 @entity1 : 28 @entity1 and 15 @entity1 with a mean age of 39.3 years (range 16-68 years). The @entity1737 was confirmed by clinical, electromyographic data and the presence of antibodies to @entity934 receptors. RESULTS: Computed tomography objectified thymic mass in 14 cases (32.5%) enlarged thymus without visible mass in eight cases (18.6%). All patients received anticholinesterase, cortico steroids in 25 cases and in three cases plasmapheresis was required. The surgical approach was total sternotomy (n=32 cases), cervicotomy (n=2), cervical and manubriotomy (n=1), a manubriotomy (n=3) and a thoracotomy in five cases ( @entity704 ). All @entity1 underwent a total thymectomy associated or not with resection of the @entity5 . Intensive Care Unit was necessary for at least 24h up to six days. The postoperative course was marked by a myasthaenic crisis (n=2) and @entity1576 (n=3) with a favourable outcome. The prognosis was marked by a complete remission in 14 cases, partial remission in 11 @entity1 , stabilisation (n=16 cases) and increasing crisis in two @entity1 . CONCLUSION: Thymectomy certainly allows clinical improvement and reduced crisis of @entity1737 . Long term monitoring will confirm the benefit of non-oncological thymectomy alone or in combination with standard treatments for @entity1 with generalised @entity1737 without @entity704 .

title: Surgery of @entity1737 associated or not with XXXX : a retrospective study of 43 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity704 :: ('MESH:D013945', 'Disease') :: ['thymoma', 'lateralised thymoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia gravis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity704 :: (MESH:D013945,Disease) :: ['thymoma']


abstract: AIM: The selection criteria for @entity1 with @entity157 ( @entity157 ) to undergo liver transplantation should accurately predict posttransplant recurrence while not denying potential beneficiaries. In the present study, we attempted to identify risk factors associated with posttransplant recurrence and to expand the selection criteria. @entity1 AND METHODS: Adult @entity1 with @entity157 who underwent liver transplantation between November 2004 and September 2012 at our centre were recruited into the current study (N=241). Clinical and pathological data were retrospectively reviewed. @entity1 who died during the perioperative period or died of non-recurrence causes were excluded from this study (N=25). All potential risk factors were analysed using uni- and multi-variate analyses. RESULTS: Sixty-one recipients of 216 qualified @entity1 suffered from recurrence. Similar recurrence-free and long-term survival rates were observed between living donor liver transplant recipients (N=60) and deceased donor liver transplant recipients (N=156). Total @entity5 volume (TTV) and preoperative percentage of lymphocytes (L%) were two independent risk factors in the multivariate analysis. We propose a prognostic score model based on these two risk factors. @entity1 within our criteria achieved a similar recurrence-free survival to @entity1 within the Milan criteria. Seventy-one @entity1 who were beyond the Milan criteria but within our criteria also had comparable survival to @entity1 within the Milan criteria. CONCLUSIONS: TTV and L% are two risk factors that contribute to posttransplant recurrence. Selection criteria based on these two factors, which are proposed by our study, expanded the Milan criteria without increasing the risk of posttransplant recurrence.

title: Scoring selection criteria including total XXXX volume and pretransplant percentage of lymphocytes to predict recurrence of @entity157 after liver transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumour']


abstract: Major @entity174 ( @entity174 ) due to @entity130 results in lower @entity5450 (LUTI) in up to 10% of cases. Significant comorbidity may result and this is particularly the case for @entity130 . The increase in @entity130 due to improvised explosive devices in recent conflicts has revealed a complex injury cohort. The incidence of @entity174 related LUTI in these casualties is up to three times higher than that seen in civilian @entity1 with @entity174 . A complete understanding of LUTI following @entity174 is still lacking. Complex fractures of the anterior pelvic arch are associated with LUTI and initial management is largely conservative. In @entity130 , the combination of the blast wave, penetrating fragment and bodily displacement results in @entity4422 combined with gross perineal and pelvic soft-tissue destruction and traumatic femoral amputations. These are some of the most challenging injuries that any surgical team will manage and life saving measures are the priority. There are established pathways for the management of LUTI following @entity130 related @entity174 . @entity130 are more complex and require a significantly different approach. This paper outlines the developments in the understanding and management of @entity174 -related LUTI, focussing primarily on @entity130 and early management. Recent military surgical experience is discussed, highlighting the significant differences to civilian practice.

title: XXXX -related urethral and bladder injury.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pelvic ring fracture', 'pelvic fracture', 'PRF']

entities_list: @entity4422 :: ('MESH:D005597', 'Disease') :: ['open pelvic fracture']

entities_list: @entity5450 :: ('MESH:D014570', 'Disease') :: ['urinary tract injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['unrecognised injury', 'military injuries', 'blunt trauma', 'injury mechanisms', 'Military injuries', 'battlefield injuries']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Pelvic fracture']


abstract: AIM: To assess the added information gained from computed tomography (CT) or magnetic resonance imaging ( @entity7994 ) of the abdomen over abdominal ultrasound in @entity1 undergoing staging of @entity3969 . MATERIALS AND METHOD: Fifty-two consecutive @entity1 with histologically proven @entity3969 were identified. Each had an initial staging abdominal ultrasound followed by either a @entity7994 examination of the abdomen. Details including @entity5 size, site, and characteristics, presence of lymph nodes, local invasion, evidence of @entity10230 , and any other relevant finding were gathered from the report of each ultrasound and @entity7994 . Each @entity7994 was then re-reviewed by a consultant paediatric radiologist and a paediatric radiology fellow. The difference in findings between the ultrasound and cross-sectional imaging were noted. RESULTS: Twelve @entity1 were excluded from the study because the @entity7994 was performed before the ultrasound, or imaging was incomplete. Twenty-six @entity1 were female, 14 male. The ages ranged from 9 months to 10.8 years (mean 3.75 years). Twenty-one @entity1 out of the remaining 40 had additional findings detected on the @entity7994 examination that had not been reported on the ultrasound. The most important additional findings included three @entity1 with @entity10230 and two with @entity5 . Other findings included two @entity1 with @entity5 haemorrhage, four with @entity1600 , three with inferior vena cava (IVC)/renal vein @entity715 , four with adjacent organ invasion, one @entity1 where the origin of the @entity5 was confirmed as renal, and one @entity1 where possible liver invasion was excluded. CONCLUSION: In over half the @entity1 , @entity7994 added additional information in the local staging of @entity3969 . Sole reliance on ultrasound for Wilms' staging risks missing significant abnormalities.

title: Added value of abdominal cross-sectional imaging ( @entity7994 ) in staging of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity10230 :: ('MESH:C536399', 'Disease') :: ['nephroblastomatosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'contralateral tumours', 'abdominal tumour']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['abdominal lymph node enlargement']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ["Wilms' tumours"]

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity3969 :: (MESH:D009396,Disease) :: ['Wilms' tumours']


abstract: PURPOSE: @entity1205 -based chemotherapy (DTX) improves @entity1349 ( @entity1349 ) of @entity1 with metastatic castration-resistant @entity263 (mCRPC). Considering the potential existence of @entity342 receptors that remain active at this stage, we aimed to assess the impact of the combined use of @entity342 deprivation therapy (ADT) with DTX for mCRPC. MATERIALS AND METHODS: We performed a single-institutional retrospective analysis of @entity1 with mCRPC who received either DTX alone (DTX group, n=21) or concurrent DTX and ADT (DTX+ADT group, n=26) between August 2006 and February 2014. All @entity1 received DTX doses of 75 mg/m   every three weeks for at least three cycles. In the DTX+ADT group, all @entity1 used luteinizing hormone releasing hormone agonist continuously as a concurrent ADT. RESULTS: The median follow-up period was 24.0 months (interquartile range 12.0-37.0) for the entire cohort. The median radiographic progression-free survival (rPFS) was 9.0 months and 6.0 months in the DTX+ADT and DTX groups, respectively (log-rank p=0.036). On multivariable Cox regression analysis, concurrent administration of ADT was the only significant predictor of rPFS [hazard ratio (HR)=0.525, 95% confidence intervals (CI) 0.284-0.970, p=0.040]. The median @entity1349 was 42.0 and 38.0 months in the DTX+ADT and DTX groups, respectively (log-rank p=0.796). On multivariable analysis, hemoglobin level at the time of DTX initiation was associated with @entity1349 (HR=0.532, 95% CI 0.381-0.744, p<0.001). CONCLUSION: In chemotherapy-naive @entity1 with mCRPC, the combined use of ADT with DTX improved rPFS. Our result suggests that the concurrent administration of ADT and DTX is superior to DTX alone.

title: Survival Outcomes of Concurrent Treatment with @entity1205 and @entity342 Deprivation Therapy in Metastatic Castration-Resistant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['Docetaxel']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']


abstract: OBJECTIVE: To investigate how sociocultural factors influence management of @entity158 from @entity3458 by comparing the experiences of those who usually manage their @entity158 at home with those who are more frequently admitted to hospital for management of their @entity158 . DESIGN: Qualitative analysis of semistructured individual interviews and focus group discussions. @entity1 : 57 @entity1 with genotype SS or S/beta-thal (44 subjects) or SC (9) (4 were unknown). 40 @entity1 took part in focus groups, six took part in both focus groups and interviews, and nine were interviewed only. @entity1 were allocated to focus groups according to number of hospital admissions for @entity158 crisis management during the previous year, ethnic origin, and sex. RESULTS: The relation between @entity1 with @entity3458 and hospital services is one of several major non-clinical dimensions shaping experiences of @entity158 management and behaviour for seeking health care. Experiences of hospital care show a range of interrelated themes, which are common to most @entity1 across variables of sex, ethnicity, and hospital attended: mistrust of @entity1 with @entity3458 ; stigmatisation; excessive control (including both over- and undertreatment of @entity158 ); and neglect. Individuals respond to the challenge of negotiating care with various strategies. @entity1 with @entity3458 who are frequently admitted to hospital may try to develop long term relationships with their carers, may become passive or @entity146 in their interactions with health professionals, or may regularly attend different hospitals. Those individuals who usually manage their @entity158 at home express a strong sense of self responsibility for their management of @entity158 and advocate self education, assertiveness, and resistance as strategies towards hospital services. CONCLUSIONS: The current organisation and delivery of management of @entity158 for sickle cell crisis discourage self reliance and encourage hospital dependence. Models of care should recognise the chronic nature of @entity3458 and prioritise @entity1 ' involvement in their care.

title: Experiences of hospital care and treatment seeking for XXXX from @entity3458 : qualitative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'Participants', 'PARTICIPANTS']

entities_list: @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell disorders', 'sickle cell disease']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: INTRODUCTION: @entity299 ( @entity299 ) are rare @entity5 of dismal prognosis. METHODS: Data of 124 @entity1 with @entity299 referred to institutions of the @entity242 Group (FSG) from 1977 and 2010 were reviewed. RESULTS: Median age was 48.8years. @entity299 were poorly-differentiated @entity242 (N=45, 36.3%), @entity5426 (N=40, 32.3%), @entity1822 (N=16, 12.9%) and others (N=23, 18.6%). At diagnosis, 100 @entity1 (80.6%) were localised and 24 (19.4%) metastatic. @entity5 were located in the right (N=47, 38.8%), left atrial cavities (N=45, 37.2%) or encompassed several locations in nine cases (7.4%). Surgery was performed in 81 cases (65.3%). Heart transplant was performed in five @entity1 . Radiotherapy adjuvant (N=18, 14.5%) or alone (N=6, 4.8%) was performed in non-metastatic @entity1 only (N=24, 19.4%). With a median follow-up of 51.2months, median overall survival (OS) was 17.2months for the entire cohort, 38.8months after complete resection versus 18.2 after incomplete resection and 11.2months in non-resected @entity1 . Radiotherapy was associated with improved progression-free survival (PFS) on multivariate analysis. Chemotherapy was significantly associated with better OS only in non-operated @entity1 but not in operated @entity1 . In non-metastatic @entity1 , surgery (hazard ratio [HR]=0.42, p<0.001), male gender (HR=0.56, p=.032) was associated with better OS and surgery (HR=0.61; p=.076), radiotherapy (HR=0.43; p=.004) and chemotherapy (HR=0.30, p=.003) improved PFS. CONCLUSION: Only surgical resection is associated with a perspective of prolonged survival. Chemotherapy is associated with a better outcome in non-resected @entity1 .

title: XXXX : a retrospective study of the @entity242 Group.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['French Sarcoma', 'sarcomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumours', 'tumours']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcomas']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['leiomyosarcomas']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['PCS', 'Primary cardiac sarcomas']

answer: @entity299 :: (MESH:D006331,Disease) :: ['Primary cardiac sarcomas']


abstract: BACKGROUND: Laparoscopic techniques are currently used for curative resection of @entity14 although long-term results from controlled clinical trials are not available yet that prove laparoscopic procedures are adequate. METHODS: All @entity1 who under-went a curative resection of a @entity14 from 1995 to 1997 were included in a prospective cohort study to evaluate the short- and long-term results. RESULTS: Laparoscopic colorectal resections were accomplished in 68 @entity1 . In only 3 @entity1 was an @entity652 (stage 0) found, and 10 @entity1 had multiple liver metastases at the time of palliative resection. An oncological resection was performed in 55 @entity1 . The average age was 62.8 +/- 14.6 years (29 female and 26 male @entity1 ). Eleven right colectomies, 1 left colectomy, 21 sigmoid resections, 16 proctosigmoidectomies and 6 abdominoperineal resections were carried out. Two @entity1 (3.6%) were lost during follow-up. The median follow-up was 27.1 months (range 9.1-45.1 months). No port-site metastases were found. Two @entity1 who are still alive after sigmoid resection suffered from a recurrence. The first @entity1 underwent only limited lymphadenectomy because of synchronous @entity706 . The second @entity1 developed bilateral lung metastases. Only one @entity1 died during the follow-up period because of @entity583 . CONCLUSION: Although the follow-up is short, it seems that the recurrence rate is low. Controlled multicenter clinical trials are currently performed to evaluate whether laparoscopic surgery is really adequate to treat @entity14 .

title: [Long-term results after laparoscopic resection of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal tumor', 'colorectal cancer']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']


abstract: Our objective was to quantify the targeting of the monoclonal antibody (mAb) MX35 F(ab')2 to micrometastatic @entity43 . This mAb detects a Mr 95,000 glycoprotein with homogeneous distribution on 80% of @entity43 specimens. Six @entity1 with minimal @entity66 from an imaging trial were injected with 2 or 10 mg of 131I- and 125I-labeled mAb MX35 F(ab')2. Biopsied samples were removed at second-look laparotomy 1-5 days post-i.v. or -i.p. infusion of antibody. Serial cryostat sections were stained by indirect immunoperoxidase method for antigen distribution and exposed to storage phosphor screens for quantitative autoradiography. Coregistration of @entity5 histology, antigen expression, and radionuclide distribution demonstrated specific localization in micrometastatic @entity5 foci (50 micrometer to 1 mm) found within tissue stroma. The radiolabeled antibody uptake determined by well scintillation counts ranged between 5.2 and 223.5 x 10(-4) percentage of injected dose/g of @entity5 tissue for 131I. Specific localization of mAb in @entity5 was determined by @entity5 :normal tissue (fat) ratios ranging from 0.9:1 to 35.9:1 for 131I. The high resolution and linear response of the storage phosphor screen imager was used to estimate the radionuclide activity localized in each micrometastatic site. Quantitation of phosphor screen response revealed microCi/g values of 0.026-0.341 for normal tissue and 0.184-6.092 for @entity5 biopsies, evaluated 4 or 5 days post-antibody injection. The @entity5 :normal tissue (adjacent to @entity5 ) ratios were between 1 and 4 times greater using the phosphor screen method than well counter measurements, but even larger variations of ratios up to @entity19 were observed between @entity5 cell foci and stromal cells within the same tissue section. This study has demonstrated that mAb MX35 F(ab')2 localizes to the micrometastatic @entity43 deposits within the peritoneal cavity. The dosimetry results suggest a therapeutic potential for this antibody in @entity1 with minimal @entity66 (<5 mm).

title: Distribution of radiolabeled monoclonal antibody MX35 F(ab')2 in tissue samples by storage phosphor screen image analysis: evaluation of antibody localization to micrometastatic disease in XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinoma', 'ovarian tumor', 'epithelial ovarian cancer']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

answer: @entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian cancer']


abstract: BACKGROUND: Concern intensifying that @entity341 @entity166 and global environmental changes that could generate major future @entity1 pandemics. METHOD: A focused literature review was undertaken, partly informed by a forthcoming report on environment, agriculture and @entity166 of poverty, facilitated by the Special Programme for @entity66 . RESULTS: More than ten categories of @entity166 emergence exist, but none formally analyse past, current or future @entity66 . Other evidence suggests that the dominant public health concern focuses on two informal groupings. Most important is the perceived threat of newly recognised @entity281 , especially viruses that arise or are newly discovered in developing countries that originate in species exotic to developed countries, such as non- @entity1 primates, bats and rodents. These pathogens may be transmitted by insects or bats, or via direct @entity1 contact with bushmeat. The second group is new strains of @entity683 arising from intensively farmed @entity1573 or @entity1707 , or @entity341 from Asian "wet markets" where several bird species have close contact. Both forms appear justified because of two great pandemics: @entity645 / @entity791 (which appears to have originated from bushmeat hunting in Africa before @entity341 globally) and Spanish @entity683 , which killed up to 2.5% of the @entity1 population around the end of World War I. Insufficiently appreciated is the contribution of the milieu which appeared to facilitate the high disease burden in these pandemics. Additionally, excess @entity148 over @entity341 @entity166 diverts attention from issues of greater public health importance, especially: (i) existing (including neglected) @entity166 and (ii) the changing milieu that is eroding the determinants of immunity and public health, caused by adverse global environmental changes, including climate change and other components of stressed life and civilisation-supporting systems. CONCLUSIONS: The focus on novel pathogens and minor forms of anti-microbial resistance in @entity341 disease literature is unjustified by their @entity66 , actual and potential, and diverts attention from far more important health problems and determinants. There is insufficient understanding of systemic factors that promote pandemics. Adverse global change could generate circumstances conducive to future pandemics with a high @entity66 , arising via anti-microbial and insecticidal resistance, under-nutrition, conflict, and public health breakdown.

title: XXXX emergence and global change: thinking systemically in a shrinking world.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Tropical Diseases', 'burden of disease']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emerging']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases', 'infectious disease']

answer: @entity166 :: (MESH:D003141,Disease) :: ['Infectious disease']


abstract: This study was designed to explore the value of @entity450 ( @entity450 ) as a predictor of therapeutic response to @entity21172 (MD) in @entity1 with postural @entity591 (POTS). One hundred and eight @entity1 diagnosed with POTS and 20 healthy control @entity1 were enrolled. All @entity1 with POTS received MD and were followed up for 3 months. @entity450 of @entity432 for each @entity1 was measured by vascular ultrasound. Symptom scores, @entity450 values, and head-up test (HUT)/head-up tilt test (HUTT) outcomes were investigated before and after treatment. A receiver operating characteristic curve was used to explore the value of @entity450 as a predictor. Baseline @entity450 (%) and increased heart rate (beats per minute) during HUT/HUTT were significantly greater in @entity1 with POTS compared with control @entity1 ( @entity450 : 11    3% vs 6    2%, p <0.001; increased heart rate: 38    9 vs 7    7 beats/min, p <0.001, respectively). Before treatment, MD responders had greater @entity450 values than MD nonresponders (p <0.05). Symptom scores, excessive increases in heart rate during HUT, and increased @entity450 values were all reduced significantly after treatment (all p <0.05). The receiver operating characteristic curve for the predictive value of @entity450 showed the area under the curve to be 0.790 (95% confidence interval: 0.679 to 0.902; p <0.001) at 1-month and 0.803 (95% confidence interval: 0.669 to 0.936; p <0.01) at 3-month therapy. @entity450 of 9.85% had a high sensitivity (1-month therapy: 71.6%; 3-month therapy: 74.4%) and specificity (1-month therapy 77.8%; 3-month therapy: 80%). In conclusion, @entity450 is a predictor of the efficacy of MD for treating @entity1 with POTS.

title: Flow-mediated vasodilation as a predictor of therapeutic response to @entity21172 in XXXX with postural @entity591 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'participant']

entities_list: @entity21172 :: ('MESH:D008879', 'Chemical') :: ['midodrine hydrochloride']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['flow-mediated vasodilation', 'FMD']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['orthostatic tachycardia syndrome']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['brachial artery']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: PURPOSE AND BACKGROUND: Interventional radiologic procedures play an important role in the management of peripheral @entity432 . Percutaneous transluminal interventions as angioplasty (PTA) and implantations of metal-stents injure the wall of the blood vessels resulting in @entity1373 of the intima and media. In spite of adequate anticoagulation therapy restenosis and reocclusion frequently occur. Our study was designed to prevent @entity1373 of the intima by percutaneous radiation therapy. @entity1 AND METHODS: A total of 24 @entity1 had a stent implanted in their superficial femoral artery from 1990 to 1992. Eleven @entity1 received percutaneous radiation therapy of the enlarged stent area on five consecutive days with a single dose of 2.5 Gy thus resulting in a total dose of 12.5 Gy. Both @entity1 groups were compared. None of the @entity1 in the radiation group suffered from complications. RESULTS: In the seven months following stent implantation and radiation only two of eleven @entity1 in the radiation group suffered from occlusion of the stent that had to be treated by vascular surgery. In comparison five of 13 @entity1 treated with stent implantation alone suffered from occlusion of the stent within the first eight to nine months. CONCLUSION: In spite of a small case number our study shows a positive influence of percutaneous radiation therapy on the extent of @entity1373 of the intima after stent implantation leading to lower reocclusion rates. Whether these results can be improved by alternative dose-fractionation schedules has to be addressed by further studies.

title: [Preventive percutaneous radiotherapy for avoiding XXXX of the intima following angioplasty together with stent implantation].

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusive disease']

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

answer: @entity1373 :: (MESH:D006965,Disease) :: ['hyperplasia']


abstract: OBJECTIVES: Although it is understood that work-related factors, including job demands, job control, and workplace support, are associated with workers' health and well-being, the role played by personal characteristics, especially workaholism, has not been fully investigated. This study examined workaholism's associations with @entity1643 with disability, and sickness absence among Japanese workers. METHODS: A cross-sectional Internet survey was conducted using self-administered questionnaires. Data from 3,899 Japanese workers were analyzed. Workaholism was measured using the Dutch Workaholism Scale (DUWAS). Scores were divided into tertiles, where respondents were classified into three groups (high, middle, and low). Depressive mood as a measure of psychological ill health was assessed using the SF-36 mental health subscale, and @entity1643 using a standardized question. Sickness absence, except that due to physical injuries, was categorized either as absence due to mental health problems or to physical/somatic problems including the common cold. Multiple logistic regression analyses were conducted to examine the association between workaholism and @entity1643 with disability, and sickness absence, adjusting for demographic characteristics, job demand, job control, and workplace support. RESULTS: Compared to the low workaholism group, the middle and high workaholism groups had significantly higher odds for @entity308 mood (Odds ratio (OR)=1.93 and 3.62 for the middle and high groups, respectively), @entity615 (ORs=1.36 and 1.77 for the middle and high groups, respectively). Workaholism was more strongly associated with sickness absence due to mental health problems than that for other reasons (ORs=1.76 vs. 1.21 for the middle group and 3.52 vs. 1.37 for the high groups). CONCLUSIONS: Workaholism is significantly associated with poor @entity615 , and sickness absence, particularly from mental health problems. Therefore, workaholism must be considered when addressing well-being of workers.

title: Workaholism as a risk factor for XXXX , and sickness absence.

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['psychological health, disabling back pain', 'disabling back pain']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'depressive mood, low back pain', 'psychological ill health, low back pain']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

answer: @entity615 :: (MESH:D001416,Disease) :: ['depressive mood, disabling back pain']


abstract: To correlate Heidelberg Retina Tomograph (HRT) @entity1103 ( @entity1103 ) index with severity of @entity6 and systemic factors. A total of 300 @entity6 @entity1 were recruited for the study for each of them a value for the macular @entity4 index was obtained using the HRT II. @entity1 ' age, gender, duration and @entity6 , latest HbA1c result and presence or absence of co-morbid factors ( @entity101 , @entity741 , @entity8 ) were recorded together with the stage of @entity6 . These were correlated with @entity1103 . Out of 300 @entity1 , HRT defined macula @entity4 was seen in 68 @entity1 (22.6%). There is a wider and higher range (95% percentile) of macula @entity4 index in the severe non proliferative @entity6 (NPDR) group. Independent samples t test showed significant difference between the severe NPDR group and no DR group (p<0.001), mild NPDR group (p<0.05) and moderate NPDR group (p<0.05). A higher macula @entity4 index was also found to have a low degree of correlation with more advanced stages of @entity989 (r=0.310; p<0.001). Also @entity8 showed a strong and significant correlation with @entity1103 . @entity101 had moderately significant correlation with @entity1103 . This study found no correlation between @entity741 and @entity1103 . HRT derived scanning laser @entity4 index is a reliable objective tool to evaluate @entity6 and systemic risk factors.

title: Scanning laser XXXX index: a reliable tool to correlate with @entity6 and systemic risk factors?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'type of diabetes mellitus', 'diabetic retinopathy']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['derived macular edema', 'DME']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

answer: @entity4 :: (MESH:D004487,Disease) :: ['edema']


abstract: During 1987-1996, 39 of 720 @entity1 hospitalized (most for severe @entity161 ) were diagnosed as having @entity1907 (5.4%, 975 per 105 per year). In 1992-1993, after a cluster of 5 cases was found, all @entity1 were screened by PPD skin test and chest X-ray and 16 more cases were identified. Diagnosis was confirmed bacteriologically in only 10 of them but there were typical radiological findings in the others. 39 were treated with a multi-drug regimen. In addition, 333 exposed @entity1 and 21% who had converted their skin tests were given isoniazid preventive therapy. A small increase in levels of liver enzymes was common, but significant abnormality (over 4 times the upper limit of normal) was found in only 7 @entity1 , in whom therapy was therefore stopped or changed. During a follow-up period of 4 years, 2 more developed @entity378 and 33 converted their PPD reactivity status. We conclude that an outbreak of @entity378 in a @entity146 hospital can be controlled with a relatively low rate of side-effects by using systematic diagnostic and therapeutic measures. However, single step screening is not sufficient. Routine screening of all new @entity1 , a high index of suspicion and contact investigation are needed.

title: [Recurrent XXXX in a @entity146 hospital, recurrent outbreaks during 1987-1996].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['active pulmonary tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['tuberculosis']


abstract: @entity2100 is one of the most frequent causes of @entity1032 . In the past, its diagnosis depended primarily on cytogenetic demonstration of chromosome fragile site Xq27.3. Recently, the gene @entity10308 has been found responsible for this disease. Here a combined method was used to study @entity2100 . A fragment (pP1fr) of DNA was subcloned from pE5.1 by polymerase chain reaction. With this probe, DNA samples from two cytogenetically proved families were analyzed by restriction fragment length polymorphisms. It was demonstrated that EcoRI polymorphism was an easy and accurate method for diagnosis of the @entity2100 . To study methylation status of @entity1 , another methylation-sensitive enzyme, BssHII, could be used together with EcoRI. The @entity9379 polymorphism of one family was also studied and showed one kb fragment as normal, and detected more precise changes in length. Prominent mosaicism necessary was characteristic in @entity9379 polymorphism. The DNA diagnosis of @entity2100 was a reliable method.

title: Fragile-X XXXX --a combination of cytogenetic and molecular approaches, with greater emphasis on DNA analysis.

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['hereditary mental retardation']

entities_list: @entity2100 :: ('MESH:D005600', 'Disease') :: ['fragile X syndrome', 'Fragile X syndrome']

answer: @entity1032 :: (MESH:D008607,Disease) :: ['mental retardation']


abstract: 70% of @entity1 with newly diagnosed and 50% of @entity1 with relapsed @entity3052 ( @entity3052 ) can achieve a complete remission with intensive chemotherapy. However, the treatment-associated mortality can be as high as 30% increasing with age, previous chemotherapy and intensity of chemotherapy. @entity2841 was first applied in 36 @entity1 with high risk @entity3052 after chemotherapy to reduce the time of critical @entity1398 . The early death rate was significantly lower in the @entity2841 group compared to 56 @entity1 of a historic control group with similar risk factors and identical chemotherapy (p less than 0.009). The rate of complete remissions was also significantly higher in the @entity2841 group (p less than 0.09). More recently, @entity2841 was used as a priming agent 24 h prior to start of chemotherapy. 25 @entity1 have entered the study up to now. The cell biological effects of @entity2841 in vivo include an immediate @entity1778 and of normal myeloid cells in the peripheral blood with a median of 2.0, an increase of cells in the S-phase of the cell cycle in bone marrow biopsies, an increase in DNA polymerase activity, an increase in @entity2592 @entity137 and immunophenotypic changes compatible with differentiation of leukemic blasts along the pathway of normal myeloid progenitors. @entity2841 has a dual effect on normal and leukemic myeloid cells. It can be safely applied in @entity1 with @entity3052 . Prospective randomized trials have to be performed to establish its role in reducing treatment @entity137 and in improving the overall treatment results.

title: In vitro and in vivo effects of rh @entity2841 in XXXX ( @entity3052 ).

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['increase of leukemic blasts']

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']


abstract: Recently, it has been shown that targeted inactivation of the @entity36384 gene in male @entity19 results in @entity246 . The @entity36384 gene encodes @entity36384 ( @entity36384 ), which is expressed in fetal Leydig cells. The testicular factor @entity36384 appears to play an important role in the transabdominal phase of testis descent, which involves development of the gubernaculum. Other studies have demonstrated that in utero exposure to @entity4742 ( @entity4743 ), a synthetic @entity172 , can lead to @entity246 both in @entity1 and in animal models. The present study was undertaken to investigate whether prenatal @entity4743 -exposure might interfere with testicular @entity36384 mRNA expression. Furthermore, the effect of @entity4743 on @entity431 ) mRNA expression level was determined, since it has been shown that @entity431 plays an essential role in transcriptional activation of the @entity36384 gene promoter. Timed pregnant @entity19 were treated with @entity4743 (100 microg/kg body weight) or vehicle alone on days E9 (gestational day 9) through @entity5355 . Control and @entity4743 -exposed @entity19 fetuses were collected at E16, @entity5355 and E18, when transabdominal testis descent is taking place. Lack of gubernaculum development in @entity4743 -exposed animals was confirmed by histological analyses at @entity5355 . Expression of @entity36384 and @entity431 mRNAs was studied in testes of control and @entity4743 -exposed fetuses at E16 and E18 by RNase protection assay. Prenatal @entity4743 -exposure resulted in a three-fold decrease in @entity36384 mRNA expression level (P<0.005), at both E16 and E18. In contrast, @entity4743 treatment had no effect on the expression of @entity431 mRNA. These results support our hypothesis that @entity4743 may interfere with gubernaculum development by altering @entity36384 mRNA expression, providing a possible mechanism by which @entity4743 may cause @entity246 .

title: Involvement of @entity36384 ( XXXX ) in @entity4742 -induced @entity246 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity246 :: ('MESH:D003456', 'Disease') :: ['cryptorchidism']

entities_list: @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol']

answer: @entity36384 :: (16336(Tax:10090),Gene) :: ['Insl3']