abstract: We report a case of @entity810 associated with cryoglobulinemic @entity631 . The @entity1 , a 49-year-old @entity1 , was referred to our hospital because of @entity697 . After admission, she developed @entity1458 , and hemodialysis was instituted. Renal biopsy was performed and the specimens showed moderate endocapillary proliferation, large deposits filling the capillary lumen ("intraluminal thrombi"), and a double-contoured appearance, which are typical morphologic features of cryoglobulinemic @entity631 . Immunoelectrophoresis showed a monoclonal increase of IgM kappa. On the basis of these findings, we diagnosed @entity4019 . Cryofiltration was performed with oral administration of @entity617 . Following the start of therapy, the @entity1 's renal function gradually improved. Because of severe @entity9427 , cryofiltration was discontinued after three sessions. However, renal function recovered and was maintained with @entity617 only. This case shows that acute @entity177 caused by cryoglobulinemic @entity631 can be reversible if immunosuppressive therapy, together with plasmapheresis in more severe cases, is instituted promptly.

title: [Successful treatment of @entity810 in a XXXX with @entity4019 using @entity617 and cryofiltration].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity4019 :: ('MESH:C565141', 'Disease') :: ['type II essential mixed cryoglobulinemia']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute nephritic syndrome']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['oliguric renal failure']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity9427 :: ('MESH:D007019', 'Disease') :: ['hypoproteinemia']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: The @entity19207 molecule links @entity5962 / @entity3546 or @entity5962 /plakoglobin complexes to the actin cytoskeleton. We studied several invasive @entity1 @entity694 cell lines lacking @entity19207 . They showed a solitary and rounded morphotype that correlated with increased invasiveness. These round cell variants acquired a more normal epithelial phenotype upon transfection with an @entity19207 expression plasmid, but also upon treatment with the @entity7131 ( @entity7131 ) activator @entity864 ( @entity865 ). Video registrations showed that the cells started to establish elaborated intercellular junctions within 30 min after addition of @entity865 . Interestingly, this normalizing @entity865 effect was not associated with @entity19207 induction. Classical and confocal immunofluorescence showed only minor @entity865 -induced changes in @entity5962 staining. In contrast, desmosomal and tight junctional proteins were dramatically rearranged, with a conversion from cytoplasmic clusters to obvious concentration at cell-cell contacts and exposition at the exterior cell surface. Electron microscopical observations revealed the @entity865 -induced appearance of typical desmosomal plaques. @entity865 -restored cell-cell adhesion was @entity5962 dependent as demonstrated by a blocking antibody in a cell aggregation assay. Addition of an antibody against the extracellular part of @entity8259 blocked the @entity865 effect, too. Remarkably, the combination of anti- @entity5962 and anti-desmoglein antibodies synergistically inhibited the @entity865 effect. Our studies show that it is possible to bypass the need for normal @entity19207 expression to establish tight intercellular adhesion by epithelial cells. Apparently, the underlying mechanism comprises upregulation of desmosomes and tight junctions by activation of the @entity7131 signaling pathway, whereas @entity5962 remains essential for basic cell-cell adhesion, even in the absence of @entity19207 .

title: Protein kinase C activation upregulates intercellular adhesion of @entity19207 -negative XXXX @entity694 cell variants via induction of desmosomes.

entities_list: @entity864 :: ('MESH:C554292|MESH:D013755', 'Chemical') :: ['12-O-tetradecanoyl-phorbol-13-acetate']

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Fish or fish oil consumption has been associated with lower blood pressure. Fish may also contain @entity5165 , which has been associated with @entity65 and higher blood pressure. Our aim was to study the associations of serum long-chain n-3 @entity1474 ( @entity5204 ) @entity7784 ( @entity8393 ), @entity23165 ( @entity16771 ) and @entity4600 ( @entity4601 ), mainly reflecting fish or fish oil intake, and hair @entity349 concentration with blood pressure. Data were available for 848 @entity1 and 909 @entity1 from the Kuopio @entity299 Risk Factor Study, aged 53-73 years. We excluded @entity1 with @entity741 , @entity64 , @entity6 or @entity101 treatment, leaving 396 @entity1 and 372 @entity1 . Log-transformed values were used to study the associations. The mean serum concentrations were 1.63% (s.d. 0.91) for @entity8393 , 0.77% (s.d. 0.16) for @entity16771 and 2.73% (s.d. 0.90) for @entity4601 of all serum @entity1718 . Multivariate-adjusted serum @entity8393 + @entity16771 + @entity4601 was associated with lower systolic blood pressure (b = -4.50, 95% confidence interval (CI) -8.02 - -0.99) and pulse pressure (b = -4.41, 95% CI -6.95 - -1.87), but not with diastolic blood pressure (b = -0.45, 95% CI -2.31-1.52). The associations were similar with @entity8393 , @entity16771 and @entity4601 evaluated individually. The mean hair @entity349 concentration was 1.42    g   g(-1) (s.d. 1.54). Hair @entity349 was not associated with blood pressure and it did not modify the association between @entity5204 and blood pressure. These results suggest that higher serum long-chain n-3 @entity5204 concentration has a modest inverse association with blood pressure in older @entity1 and @entity1 .

title: Serum long-chain n-3 XXXX , @entity5165 and blood pressure in an older population.

entities_list: @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid']

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids']

entities_list: @entity23165 :: ('MESH:C026219', 'Chemical') :: ['docosapentaenoic acid']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Ischaemic Heart Disease']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

entities_list: @entity5165 :: ('CHEBI:30785', 'Chemical') :: ['methylmercury']

answer: @entity1474 :: (MESH:D005231,Chemical) :: ['polyunsaturated fatty acids']


abstract: BACKGROUND: We recently observed @entity1 with @entity409 ( @entity409 ) or @entity102 ( @entity102 ) who developed @entity1127 ( @entity1127 ) while undergoing surveillance gastroscopies for the detection of esophageal varices or @entity355 , respectively. OBJECTIVES: To identify risk factors for GP growth and estimate its growth rate. METHODS: GP growth rate was defined as the number of days since the first gastroscopy (without @entity1127 ) in the surveillance program, until the gastroscopy when a GP was discovered. RESULTS: Gastric polyp growth rates in @entity409 and @entity102 @entity1 were similar. However, @entity1127 ( @entity1127 ) were detected more often (87.5% vs. 60.5%, P = 0.051) and at a higher number (2.57    1.33 vs. 1.65    0.93, P = 0.021) in the @entity409 @entity1 . Subgroup analysis revealed the following findings only in @entity409 @entity1 with @entity1127 : (i) a positive correlation between the GP growth rate and the @entity1 's age; the older the @entity1 , the higher the GP growth rate (r = 0.7, P = 0.004). (ii) A negative correlation between the @entity1 's age and the Ki-67 proliferation index value; the older the @entity1 , the lower the Ki-67 value (r = -0.64, P = 0.02). No correlation was detected between Ki-67 values of @entity1127 in @entity409 @entity1 and the presence of portal @entity101 , @entity281 with @entity1534 , or proton pump inhibitor use. CONCLUSIONS: In comparison with @entity102 @entity1 , @entity409 @entity1 developed @entity1127 more often and at a greater number. Young @entity409 @entity1 may have a tendency to develop @entity1127 at a faster rate than elderly @entity409 @entity1 .

title: @entity1127 Growth during Endoscopic Surveillance for Esophageal Varices or XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['HGPs', 'GPs', 'hyperplastic gastric polyps', 'polyps', 'gastric polyps']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['CLD', 'chronic liver disease']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['CRS', 'chronic reflux symptoms']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1534 :: ('210', 'Species') :: ['Helicobacter pylori']

answer: @entity355 :: (MESH:D001471,Disease) :: ['Barrett's Esophagus']


abstract: PURPOSE: Chemotherapy for @entity1149 ( @entity1149 ) remains controversial. We describe the two largest reported, randomized, parallel trials designed to determine whether the addition of chemotherapy influences duration and quality of life in localized, unresectable ( @entity1138 , @entity1260 , @entity900 [MIC]1 trial) and extensive ( @entity3778 trial) disease. @entity1 AND METHODS: Ambulatory @entity1 with @entity1149 , aged 75 years or younger, with @entity66 , were randomized in @entity23390 to receive up to four cycles of chemotherapy (CT: @entity1138 6 mg/m(2), @entity1260 3 g/m(2), and @entity900 50 mg/m(2)) every 21 days, followed by radical radiotherapy (CT + RT) or radiotherapy (RT) alone. Extensive-stage @entity1 were randomized in @entity3778 to identical chemotherapy plus palliative care (CT + PC) or palliative care (PC) alone. Short-term change in quality of life (QOL) was assessed in a subgroup of @entity1 . Data from the two trials were combined to allow multivariate and stratified survival analyses. RESULTS: Seven hundred ninety-seven eligible @entity1 were randomized, 446 in @entity23390 and 351 in @entity3778 . MIC CT improved survival in both trials (significantly in @entity3778 ). The median survival time in @entity23390 was 11.7 months (CT + RT) versus 9.7 months (RT alone) (P =.14); whereas in @entity3778 , median survival time was 6.7 months (CT + PC) compared with 4. 8 months (PC alone) (P =.03). QOL, assessed in 134 @entity1 from start of trial to week 6, showed improvement with chemotherapy and deterioration with standard treatment. In the combined analysis of 797 randomized @entity1 , the positive effect of MIC on survival was significant overall (P =.01) and after adjusting for prognostic factors (P =.01). CONCLUSION: MIC chemotherapy prolongs survival in unresectable @entity1149 without compromising QOL.

title: @entity1138 , @entity1260 , and @entity900 in unresectable XXXX : effects on survival and quality of life.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']


abstract: BACKGROUND: Previously, the authors clarified that the plasma concentration of @entity2843 ( @entity2843 ) in @entity1 with @entity356 was a significant predictor of @entity5 invasiveness and @entity3 . METHODS: To further clarify the clinical significance of @entity2843 , the authors used an enzyme-linked immunoassay to assess @entity2843 protein concentrations in samples of @entity5 tissue from 86 @entity1 who underwent primary resection for @entity356 . Concentrations in samples of normal gastric mucosa from 73 of these @entity1 also were assessed. RESULTS: Tissue @entity2843 concentrations were significantly greater in @entity356 than in normal gastric mucosa and were associated significantly with a variety of pathologic factors, including macroscopic type, depth of @entity5 invasion in the gastric wall, presence of lymphatic vessel invasion, pattern of @entity5 infiltration into the surrounding tissue, and disease stage. Significantly greater @entity2843 concentrations were found in @entity5 that were exposed to the serosal surface compared with @entity5 that were limited to the submucosal layer. @entity2843 protein was significantly greater in @entity5 with lymphatic vessel invasion, an infiltrative pattern into the surrounding tissue (INF-gamma), and in @entity5 from @entity1 with @entity5 . Survival was significantly poorer in @entity1 with @entity2843 concentrations > or = 10.0 ng/mg total protein. When @entity1 were stratified by disease stage, survival was significantly different in @entity1 with @entity5 . Multivariate analysis demonstrated that intratumoral concentrations of @entity2843 were the most significant independent factor for survival. CONCLUSIONS: These findings suggest that the intratumoral concentration of @entity2843 protein may be a good indicator of @entity146 and can serve as a significant independent predictor of survival in @entity1 with @entity356 .

title: Intratumoral concentrations of @entity2843 in XXXX with @entity356 a new biomartker for invasion and its impact on survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['tumor aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Stage III disease', 'tumors']

entities_list: @entity2843 :: ('7076', 'Gene') :: ['tissue inhibitor of matrix metalloproteinase 1', 'TIMP-1']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumors', 'gastric carcinoma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To derive and internally validate a clinical decision rule that will rule out major @entity764 in adult @entity130 @entity1 , reducing the unnecessary use of chest computed tomographic (CT) scans. METHODS: Data were retrospectively obtained from a chart review of all @entity130 @entity1 presenting to a Canadian tertiary @entity130 care centre from 2005 to 2008, with those from April 2006 to March 2007 being used for the validation phase. @entity1 were included if they had an Injury Severity Score > 12 and chest CT at admission or a documented major @entity764 noted in the @entity130 database. @entity1 with @entity2982 , a Glasgow @entity772 Scale (GCS) score  <= 8, @entity912 , or age < 16 years were excluded. RESULTS: There were 434 @entity1 in the derivation group and 180 in the validation group who met the inclusion criteria. Using recursive partitioning, five clinical variables were found to be particularly predictive of injury. When these variables were normal, no @entity1 had a major @entity764 (sensitivity 100% [95% CI 98.4-100], specificity 46.9% [95% CI 44.2-46.9], and negative likelihood ratio 0.00 [95% CI 0.00-0.04]). The five variables were @entity26 saturation (< 95% on room air or < 98% on any supplemental @entity26 ), chest radiograph, respiratory rate >=  25, chest auscultation, and @entity1514 (SCRAP). In the validation group, the same five variables had a sensitivity of 100% (95% CI 96.2-100%), a specificity of 44.7% (95% CI 39.5-44.7%), and negative likelihood ratio of 0.00 (95% CI 0.00-0.10). CONCLUSIONS: In major @entity130 with a GCS score > 8, the SCRAP variables have a 100% sensitivity for major @entity764 in this retrospective study. These findings need to be prospectively validated prior to use in a clinical setting.

title: The SCRAP Rule: The derivation and internal validation of a clinical decision rule for computed tomography of the chest in blunt XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2982 :: ('MESH:D020197', 'Disease') :: ['penetrating injury']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic palpation']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['thoracic injury']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['thoracic trauma']


abstract: OBJECT: In 1991 a new pioneering classification of severe @entity542 had been proposed, based on CT findings. Unfortunately CT cannot visualise all lesions. Especially brain stem lesions may escape CT in spite of modern equipment, but may be demonstrated by MRI. The high incidence of CT negative but MRI positive posttraumatic brain stem lesions has already been demonstrated in a limited number of cases. A statistically significant evaluation is still missing. Therefore we have investigated a series of 102 @entity772 @entity1 , in whom a statistical evaluation of MRI findings and their correlation with mortality and outcome of survivors was possible. @entity1 AND METHODS: MRI was obtained within 8 days after servere @entity542 in 102 @entity1 with a minimum of 24 hours of @entity772 . The location of the lesions. identified by a neuroradiologist who was unaware of the clinical findings, was correlated with mortality, outcome of surviors and duration of @entity772 . The correlation was analysed statistically. Follow-up ranged from 3 months to 3 years with a mean of 22 months. Four groups of lesions gave significant correlations: Grade I lesions were lesions of the hemispheres only; Grade II lesions were unilateral lesions of the brain stem at any level with or without supratentorial lesions; @entity75 were bilateral lesions of the mesencephalon with or without supratentorial lesions. Grade IV lesions were bilateral lesion of the pons with or without any of the foregoing lesions of lesser grades. RESULTS: Mortality increased from 14% in grade I lesions to 100% in grade IV lesions. The Glasgow outcome score differed significantly for each grade. The mean duration of @entity772 increased from 3 days in grade I @entity1 to 13 days in grade III. The correlations between the lesions grade I to IV with mortality, outcome of survivors and duration of @entity772 were highly significant. CONCLUSION: The statistically significant correlations between the 4 groups of severe @entity542 @entity1 , as identified by MRI, with mortality and outcome of survivors justify a new classification based on early MRI findings.

title: Classification of severe XXXX based on magnetic resonance imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries', 'head injury']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Grade III lesions']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['coma', 'comatose']

answer: @entity542 :: (MESH:D006259,Disease) :: ['head injury']


abstract: BACKGROUND: Lymphoscintigraphy is used preoperatively to identify sentinel lymph nodes (SLNs). Conventional planar scintigraphy cannot provide three-dimensional(3D) information for @entity4298 biopsy. We applied stereoscopic imaging to preoperative lymphoscintigraphy to obtain 3D information and evaluated its usefulness. METHODS: Forty-four clinical stage I @entity0 @entity1 (1 male, 43 females; age, 59.4+/-11.4 years) were enrolled in this study. Three hours after the injection of Tc-99m, 10 degrees of oblique images and routine anterior and lateral images were acquired. Anterior and lateral stereoscopic images were obtained in all studies, except for 2 @entity1 ; only lateral views were done for those. Two experienced radiologists enumerated the visualized hot nodes. RESULTS: Stereoscopic imaging delineated more hot axillary lymph nodes compared to routine planar imaging in 8 of 42 @entity1 (19.0%) on anterior view, 5 of 44 @entity1 (11.4%) on lateral view, and 11 of 44 @entity1 (25.0%) on either the anterior or lateral view. Statistically significant differences were observed between stereoscopic and routine planar imaging method on the anterior (p=0.012) and the lateral views (p=0.043). The stereoscopic imaging provided 3D information and effectively separated closely located hot nodes that were viewed as one hot node on conventional planar images. Thirty-eight out of 42 cases (90%) with anterior stereoscopic images identified the same number or more axillary hot nodes compared with lateral stereoscopic images. CONCLUSION: The stereoscopic imaging method could improve the preoperative identification of SLNs. This method is technically simple, and could be a powerful diagnostic tool for @entity4298 imaging @entity0 .

title: Stereoscopic scintigraphic imaging of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer sentinel lymph nodes']


abstract: @entity32 , @entity82 , @entity194 , malignant transformation, and @entity1031 events are hallmarks of chronic @entity660 . Extracellular @entity2036 have been implicated as inflammatory mediators in many pathological situations. However, there are minimal data detailing expression of ectonucleotidases and type-2 purinergic receptors ( @entity37171 ) in chronic @entity788 and @entity788 . We have therefore defined tissue distribution and localization of the @entity13796 family of ectonucleotidases and associated P2R in @entity1 disease. Transcripts of ectonucleotidases ( @entity13796 and @entity37172 ) together with P2R ( @entity9896 , @entity9897 , and @entity18141 ) are significantly increased in both chronic @entity788 and @entity788 . @entity13796 and @entity37172 are preferentially associated with the vasculature and stromal elements in pathological tissues. @entity9896 mRNA upregulation was associated with chronic @entity788 , and heightened protein expression was found to be localized to infiltrating cells. @entity9897 was markedly upregulated in biopsies of @entity788 tissues and expressed by fibroblasts adjacent to @entity5 . High-tissue mRNA levels of @entity13796 significantly correlated with better long-term survival after @entity5 resection in @entity1 with @entity788 . Heightened expression patterns and localization patterns of @entity13796 , @entity9896 , and @entity9897 infer associations with @entity32 and @entity5 of the pancreas. Our data suggest distinct roles for @entity13796 and P2-purinergic signaling in both tissue remodeling and fibrogenesis with respect to @entity1 @entity660 .

title: Upregulation of @entity13796 /NTPDases and P2 receptors in @entity1 XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'Chronic inflammation']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic cancer']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'neoplasia']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic diseases', 'pancreatic disease']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']

entities_list: @entity37171 :: ('p|SUB|P|2|R', 'ProteinMutation') :: ['P2R']

answer: @entity660 :: (MESH:D010182,Disease) :: ['pancreatic disease']


abstract: OBJECTIVE: To evaluate a new minimally invasive surgery for treatment of the @entity3610 ( @entity3610 ) in @entity4082 -resistant infertile @entity1 . DESIGN: Prospective study. SETTING: University teaching hospital. @entity1 (S): Thirteen @entity4082 @entity1792 -resistant anovulatory @entity1 with @entity3610 . INTERVENTION(S): Operative transvaginal hydrolaparoscopy (THL) using a coaxial bipolar electrode. MAIN OUTCOME MEASURE(S): Feasability, ovulation rate, and pregnancy rate. RESULT(S): Ovarian drilling was performed by THL in all @entity1 ; no surgical complications occurred. Mean (+/-SD) duration of follow-up time was 6.3 +/- 3.3 months. Six @entity1 recovered to have regular ovulatory cycles. Six pregnancies occurred; three were spontaneous, two occurred after stimulation and intrauterine insemination, and one occurred after IVF. The cumulative pregnancy rate was 33% at 3 months after THL and 71% at 6 months after THL. No @entity2208 occurred. CONCLUSION(S): Transvaginal hydrolaparoscopy with ovarian drilling using bipolar electrosurgery appears to be an alternative minimally invasive in @entity1 with @entity3610 who are resistant to @entity4082 therapy.

title: Operative transvaginal hydrolaparoscopy for treatment of XXXX : a new minimally invasive surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENT']

entities_list: @entity2208 :: ('MESH:D000022', 'Disease') :: ['miscarriages']

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome', 'PCOS']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene']

answer: @entity3610 :: (MESH:D011085,Disease) :: ['polycystic ovary syndrome']


abstract: PURPOSE: To perform a retrospective analysis of @entity1 with @entity13382 treated with postoperative radiotherapy (RT) at Memorial Sloan-Kettering Cancer Center. METHODS AND MATERIALS: Between January 1987 and July 2005, 85 @entity1 with PNS and nasal cavity @entity5 underwent @entity86 . Most @entity1 had @entity957 (49%; n = 42), T4 @entity5 (52%; n = 36), and the maxillary sinus (53%; n = 45) as the primary disease site. The median radiation dose was 63 Gy. Of the 85 @entity1 , 76 underwent CT simulation and 53 were treated with either three-dimensional conformal RT (27%; n = 23) or intensity-modulated RT (35%; n = 30). @entity137 were scored according to the Radiation Therapy Oncology Group radiation morbidity scoring criteria. RESULTS: With a median follow-up for surviving @entity1 of 60 months, the 5-year estimates of local progression-free, regional progression-free, distant metastasis-free, disease-free, and overall survival rates were 62%, 87%, 82%, 55%, and 67%, respectively. On multivariate analysis, squamous cell histology and cribriform plate involvement predicted for an increased likelihood of local recurrence, and squamous cell histologic features predicted for worse overall survival. None of the @entity1 who underwent CT simulation and were treated with modern techniques developed a Grade 3-4 late complication of the eye. CONCLUSION: Complete surgical resection followed by adjuvant RT is an effective and safe approach in the treatment of PNS @entity5 . Emerging tools, such as three-dimensional conformal treatment and, in particular, intensity-modulated RT for PNS @entity5 , may minimize the occurrence of late complications associated with conventional RT techniques. Local recurrence remains a significant problem.

title: Treatment of XXXX with modern radiotherapy techniques in the postoperative setting--the MSKCC experience.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Acute and late toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity13382 :: ('MESH:D010255', 'Disease') :: ['paranasal sinus (PNS) cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative RT']

answer: @entity5 :: (MESH:D009369,Disease) :: ['nasal cavity and paranasal sinus cancer']


abstract: The collagenase produced by mesenchymal cells has been thought to have a great importance in the pathophysiology of connective tissue metabolism and prolongation of @entity32 . The factors, such as @entity1192 , released by inflammatory cells have been known to induce mesenchymal cells to produce collagenase. In the present study, the collagenase activity of the nasal secretions were estimated using @entity2823 -labelled collagens as substrates. The factor, enhancing the fibroblasts to produce collagenase, was also isolated from nasal secretions and partially characterized. The fibroblasts used in the present study were cultured with explant of the sections of nasal polyp obtained from a @entity1 with chronic @entity1244 . The collagenase activity in nasal secretions from @entity1 with chronic @entity1244 was high, whereas that of allergic nasal secretions was extremely low. Furthermore, the collagenase productions of nasal polyp-derived fibroblasts were enhanced by the extracts of nasal secretions from @entity1 with chronic @entity1244 . Crude extracts of nasal secretions were fractionated by @entity1329 precipitation. The active materials precipitated by 50% to 80% @entity1329 were further purified by Sephadex G-75 gel chromatography. The molecular weight determination of the active fraction checked by HPLC utilizing for @entity38624 ,000 SW gel column indicates 20,000 daltons for the active materials. However, the collagenase production of @entity1 microvascular endothelial cells derived from nasal mucosa was not enhanced by this factor. Although either the origin or the nature was not confirmed, the factor was considered to relate to the prolongation of @entity32 in the nasal and paranasal sinus pathology. Analysis of these factors will expected to establish methods for new therapeutics in @entity32 .

title: [A study on collagenase production of nasal polyp-derived fibroblasts stimulated by nasal secretions of chronic XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation']

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity1329 :: ('MESH:D000645', 'Chemical') :: ['ammonium sulfate']

answer: @entity1244 :: (MESH:D012852,Disease) :: ['sinusitis']


abstract: @entity43610 ( @entity43610 ) is a 38- @entity1472 acid peptide ( @entity11697 ) or a truncated peptide with the same 27 @entity1472 -terminal residues ( @entity11697 ). The @entity43610 receptor was solubilized from @entity291 brain membranes with @entity11040 and purified 30-fold by the combination of @entity8851 -Toyopearl and hydroxylapatite chromatographic analyses. The partially purified @entity43610 receptors were mixed with biotinylated @entity11697 to form receptor-ligand complexes and then adsorbed onto avidin-agarose. The adsorbed @entity43610 receptors were eluted with an acidic buffer containing 1.0 M @entity1219 (pH 4.0). The eluted receptors were purified further by @entity692 and gel filtration chromatography. A single protein band with a M(r) = 55,000-60,000 was found in the final preparation by @entity3208 - @entity2975 gel electrophoresis and @entity575 staining. Affinity labeling of the purified receptors with 125I- @entity11697 labeled the M(r) 55,000-60,000 protein specifically. The dissociation constant and the specific activity of the purified receptors were 25.8 pM and 17.2 nmol of ligand binding per mg of protein, respectively. Inhibitory constants determined by competitive binding experiments were 30.0 pM for @entity11697 , 4.6 pM for @entity11697 , and 37.3 nM for vasoactive intestinal peptide. Therefore, the purified @entity43610 receptor retained high affinity and ligand specificity. The sequence of the @entity1472 -terminal 29 residues was derived from the purified receptor.

title: Purification and characterization of the receptor for XXXX .

entities_list: @entity11040 :: ('MESH:D004072', 'Chemical') :: ['digitonin']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity43610 :: ('615187(Tax:9913)', 'Gene') :: ['PACAP', 'Pituitary adenylate cyclase-activating polypeptide']

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxylapatite']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

answer: @entity43610 :: (615187(Tax:9913),Gene) :: ['pituitary adenylate cyclase-activating polypeptide']


abstract: @entity697 in pregnancy is the most common non- @entity2143 complication warranting emergency laparotomy. A retrospective study of 52 pregnant @entity1 who underwent laparotomy for suspected @entity697 between June 1982 and June 1995 revealed a histopathological diagnosis in 29 (56%) @entity1 . The hospital incidence for @entity697 in pregnancy was 0.09% (1 in 1102 deliveries). There were 10 (19%) @entity1 who presented in the first trimester, 31 (60%) second trimester, 8 (15%) third trimester and 3 (6%) @entity1 in the puerperium. @entity490 in the right lower quadrant was the most common presenting symptom. Abdominal tenderness and rebound tenderness were the most common physical signs, although the latter was less marked in late pregnancy. Preoperative laboratory investigations were equivocal in reaching a decision for surgical intervention. Laparotomy was performed within 24 hours of onset of symptoms in 67% of @entity1 . Perforation of the appendix was found in 4 (14%) @entity1 , all of whom had symptoms exceeding 24 hours. @entity2737 occurred in 4 (9.6%) @entity1 , 3 of whom had a @entity2466 . There were 2 (9%) fetal losses among the @entity1 with negative laparotomies. Five (17%) other fetuses were lost in the group with diseased appendix, three of these were in @entity1 with @entity2466 . There was no maternal death in the study.

title: XXXX in pregnancy. A review of 52 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['Acute appendicitis', 'acute appendicitis']

entities_list: @entity2466 :: ('MESH:D001063', 'Disease') :: ['perforated appendix']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['Wound infection']

entities_list: @entity2143 :: ('MESH:D048949', 'Disease') :: ['obstetric']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['Abdominal pain']

answer: @entity697 :: (MESH:D000208,Disease) :: ['Acute appendicitis']


abstract: Recent studies show that, @entity32 plays an important role in the initiation and progression of @entity731 and in the pathogenesis of acute cardiovascular events. There is a possible association between @entity67 following @entity583 and high Sensitivity @entity1851 (HS-CRP) and @entity414 . In this study we assessed the relationship between HS-CRP and @entity414 with LVEF and Killip Class in @entity1 with @entity583 ( @entity583 ). In a cross sectional study, 188 @entity1 (63 females and 125 males) with @entity583 (STEMI) who were admitted in CCU ward in Emam Khomeini Hospital, Tehran/Iran, were entered. @entity414 and HS-CRP were measured within first day of admission. We measured ejection fraction (LVEF) and used Killip classification system. The mean age of @entity1 was 60.4  9.2 years. The mean of @entity414 was 5.9  1.6, 6.6  2.1, 7.1  2.1 and 9.4  1.3 in @entity1 with Killip Class I, II, III and IV, respectively (P=0.005). The mean of HS-CRP was 1.9  1.4, 14.2  10.9, 12.2  10.9 and 15.7  6.7 in @entity1 with Killip Class I, II, III and IV, respectively (P=0.005). There was a relationship between HS-CRP and LVEF (Correlation coefficient= -0.788, P<0.001), but there was not between @entity414 and LVEF (Correlation coefficient= -0.111, P=0.129), The plasma concentration of @entity1851 correlated with LVEF and Killip Class in @entity1 with @entity583 but serum @entity414 was just correlated with Killip Class IV. It seems that plasma concentrations of HS-CRP and @entity414 are useful for prediction of development of @entity712 in @entity583 @entity1 . More future studies are necessary for final judgment.

title: Correlation between the serum levels of XXXX and HS-CRP with the occurrence of early systolic failure of left ventricle following @entity583 .

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['Uric acid', 'uric acid']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular dysfunction']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity414 :: (MESH:D014527,Chemical) :: ['uric acid']


abstract: PURPOSE: The precise importance of factors affecting morbidity and mortality in @entity1 with complicated abdominal wall hernias undergoing emergency surgical repair has been not completely elucidated. @entity1 AND METHODS: A retrospective multicentric study of all @entity1 (n = 402) with @entity4036 who underwent urgent operations over 1-year period was conducted in ten hospitals. Logistic regression analysis was used to evaluate variables that affect morbidity and mortality. RESULTS: Thirty-five percent of @entity1 had @entity18659 , 20% umbilical @entity547 , and 15% incisional @entity547 . Mesh repair was used in 92.5% of cases. Intestinal resection was required in 49 @entity1 . Perioperative complications occurred in 130 @entity1 , and 18 @entity1 died (mortality rate 4.5%). Complications and mortality rate were significantly higher in the group of intestinal resection. @entity1 older than 70 years also showed more complications, required intestinal resection more frequently, and had a higher mortality rate than younger @entity1 . In the logistic regression analysis, age over 70 years, intestinal resection, and American Society of Anesthesiologists (ASA) III/IV class emerged as independent predictors of a poor outcome. Based in our results, we propose a simple schema to calculate risk of @entity204 in these @entity1 . CONCLUSION: Using multivariate logistic regression analysis, probabilities of @entity204 after complicated @entity4036 surgery are increased in @entity1 with: age over 70 years, high ASA class, and associated intestinal resection. Guidelines should be developed to improve prognosis in these @entity1 .

title: Risk of XXXX after emergency repair of abdominal wall hernias. Still waiting for improvement.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity4036 :: ('MESH:D046449', 'Disease') :: ['abdominal wall hernia']

entities_list: @entity18659 :: ('MESH:D006550', 'Disease') :: ['inguinal hernia, 22% femoral hernia']

answer: @entity204 :: (MESH:D003643,Disease) :: ['death']


abstract: BACKGROUND: 1 in 1000 @entity1 will be diagnosed with @entity5 during pregnancy. The outcomes for @entity1149 ( @entity1149 ) diagnosed during pregnancy are dismal, with most @entity1 dying within one year. Actionable mutations are more likely to be found among younger @entity1 with @entity1149 . However, most previous reports of @entity1149 diagnosed during pregnancy did not include molecular genotyping. METHODS: We performed a retrospective analysis of @entity1 seen at our institution between 2009 and 2015 to identify @entity1 diagnosed with @entity1149 during pregnancy or the peripartum period and determined clinicopathologic features, including molecular genotype. RESULTS: We identified 2,422 @entity1 with @entity1149 , including 160 @entity1 of reproductive age. Among the @entity1 of reproductive age, eight cases of @entity1149 diagnosed during pregnancy or the peripartum period were identified, all of whom were minimal or never-smokers with metastatic @entity420 . Six of these @entity1 were found to have ALK rearrangements, while the remaining two were @entity470 mutation-positive. We observed a borderline significant association between a pregnancy/peripartum @entity1149 diagnosis and ALK-positivity (p= 0.053). All eight @entity1 diagnosed with @entity1149 during pregnancy/peripartum received treatment with genotype-directed therapies after delivery. The median overall survival (OS) has not been reached at a median follow-up of 30 months. CONCLUSIONS: Although a pregnancy/peripartum diagnosis of @entity1149 is rare, diagnostic evaluation should not be delayed in pregnant @entity1 presenting with symptoms worrisome for @entity2 . Evaluation should include testing for targetable molecular alterations.

title: Clinicopathologic Features of XXXX Diagnosed During Pregnancy or the Peripartum Period in the Era of Molecular Genotyping.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['NSCLC']


abstract: BACKGROUND: Fractional flow reserve (FFR) specifically relates to the severity of a @entity850 to the mass of tissue to be perfused. Accordingly, the larger the territory to be perfused, the greater the flow and the pressure gradient induced by maximal @entity450 . Although this notion may be considered intuitive, its unequivocal demonstration is still lacking. The aim of our study was to evaluate the influence of the amount of @entity1562 subtended to an intermediate @entity850 on FFR, especially in relation to quantitative coronary angiography. METHODS AND RESULTS: The severity of each lesion was assessed by FFR and 2-dimensional quantitative coronary angiography. The amount of jeopardized @entity1562 was evaluated using 3 validated scores specifically adapted to this aim: the Duke Jeopardy Score (DJS), the @entity296 ( @entity296 ), and the Alberta Provincial Project for Outcome Assessment in @entity301 (APPROACH) Lesion Score ( @entity2655 ). The presence of a concomitant collateralized chronic total occlusion was also reported. A total of 213 intermediate coronary stenoses in 184 @entity1 were enrolled. FFR values were correlated to minimal lumen diameter (r=0.34; P<0.0001) and diameter @entity850 (r=-0.28; P<0.0001). FFR was inversely correlated with DJS, @entity296 , and @entity2655 (r=-0.28, P<0.0001; r=-0.40, P<0.0001; and r=-0.34, P<0.0001). Lesions localized on proximal left anterior descending were related to significantly lower FFR values and to a higher rate of a positive FFR compared with those in distal left anterior descending, left circumflex, and right coronary arteries (0.80  0.09 versus 0.84  0.08 versus 0.88  0.09 versus 0.91  0.04; P<0.0001). The presence of a collateralized chronic total occlusion was associated with significantly lower FFR values (0.80  0.07 versus 0.85  0.09; P<0.005). At multivariate analysis @entity296 , minimal lumen diameter, and presence of a collateralized chronic total occlusion were confirmed as significant predictors of FFR. CONCLUSIONS: A larger amount of perfused @entity1562 subtended by a @entity850 is associated with a higher probability that an angiographically intermediate @entity3979 is functionally significant.

title: Influence of the amount of XXXX subtended by a @entity850 on fractional flow reserve.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['Myocardial Jeopardy Index', 'MJI']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['Coronary Heart Disease']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis']

entities_list: @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity1562 :: (MESH:D017682,Disease) :: ['myocardium']


abstract: PEPTY is a program developed with the aim of providing a diagnostic and therapeutic assistance in managing @entity10189 . Its theoretical basis is an accurate analysis of current concepts in peptic disease diagnosis and treatment. This was done by reviewing recent literature and consulting skilled gastroenterologists. The decision tree includes three sections dealing with diagnostic, therapeutic and monitoring problems. The diagnostic section starts by evaluating clinical data from @entity1 history and physical examination; the diagnostic hypotheses given at this level are refined and eventually confirmed by further information in the following section. Here the decision tree becomes modular in that a proper therapeutic and monitoring pathway is defined for four disease classes: gastroduodenal peptic ulcer and @entity9317 , @entity354 , @entity3621 , and @entity102 . In the therapeutic section a cost-benefit analysis of possible therapeutic choices is always performed, but the final decision is made by the user. Complications, side effects and treatment efficacy are also considered and the program finally suggests the appropriate maintenance treatment. @entity1 data display, storage and retrieval, and explanation facilities are supplied. The system can provide a 'second opinion' in the medical practice and may be a useful learning tool for medical students.

title: PEPTY: a knowledge-based program for assisting medical reasoning in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patient']

entities_list: @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic diseases']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic antral gastritis']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['erosive gastritis']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastro-oesophageal reflux']

entities_list: @entity9317 :: ('MESH:D004382', 'Disease') :: ['duodenitis']

answer: @entity10189 :: (MESH:D010437,Disease) :: ['peptic diseases']


abstract: BACKGROUND: Heterogeneously distributed @entity519 is a major characteristic of solid @entity5 . (Immuno-)fluorescence detection of @entity519 in experimental @entity5 is frequently assessed in a single central section; however, this may not necessarily be representative of the whole @entity5 . In order to determine whether analysis of one central section is exemplary of the whole @entity5 and whether different volumes have an impact on @entity5 oxygenation, we assessed the fractions of total (TH), chronic (CH), and @entity519 ( @entity519 ) throughout different layers of @entity5 of varying volumes. MATERIALS AND METHODS: Xenografted @entity1 @entity1 @entity957 of different volumes were investigated for intra- and intertumor heterogeneities. Tissue blocks located at the apical, central, and basal layer were sliced from individual @entity5 . Four serial cryosections were analyzed from each tissue block. @entity5 tissue was explored for the distribution of @entity5956 (perfusion), @entity12184 ( @entity519 ), and @entity2279 (endothelium) to assess TH, CH, and @entity519 . RESULTS: Fractions of TH, CH, and @entity519 were consistently similar in the serial sections of individual tissue blocks. However, significant differences were found between the apical, central, and basal blocks that were even opposite depending on the @entity5 volume. Pooled data from all three tissue blocks revealed significantly higher fractions of @entity519 in the large @entity5 than in the small @entity5 . CONCLUSION: @entity5 exhibit a heterogeneous and volume-dependent oxygenation status. Assessing the average fractions of TH, CH, and @entity519 from central blocks corresponds best to the average of the entire @entity5 . However, information on intratumor heterogeneities is lost, especially when considering @entity5 of substantially different volumes.

title: Intra- and intertumor heterogeneities in total, chronic, and XXXX in @entity957 . Detection and quantification using (immuno-)fluorescence techniques.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'FaDu tumors', 'tumors', 'Vital tumor']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['AH', 'acute hypoxia', 'hypoxia']

entities_list: @entity12184 :: ('MESH:C033815', 'Chemical') :: ['pimonidazole']

answer: @entity519 :: (MESH:D000860,Disease) :: ['acute hypoxia']


abstract: To control the growth of @entity5 effectively with systemic chemotherapy, we recently developed intravenously administered small-sized magnetic liposomes as an anticancer drug carrier. We previously reported that intravenously administered magnetic liposomes with incorporated @entity632 (magnetic ADR liposomes) effectively delivered ADR to the target site where a permanent magnet was implanted. In the present study, the therapeutic efficacy of this novel treatment approach, which involves a combination of magnet implantation at the target site and intravenous administration of magnetic liposomes, was further evaluated by comparing @entity5 growth rates among different administration modalities and by histological examination of treated @entity5 . Small-sized magnetic ADR liposomes with a mean diameter of 146 nm were prepared by the reverse-phase evaporation method. Syrian male hamsters inoculated with @entity421 , Os515, in the right hind limb were studied 7 days after inoculation. One day prior to the animal study, either a permanent magnet (with magnetic force) or non-magnetic alloy (without magnetic force) was implanted in the center of the @entity5 . Treatment with magnetic ADR liposomes under magnetic force showed significantly greater antitumor activity than intravenous administration of ADR solution or that of magnetic ADR liposomes without magnetic force. ADR administered as magnetic liposomes eliminated @entity353 of hamsters, one of the side effects produced by ADR. Interestingly, magnetic liposomes (without incorporated ADR) given under magnetic force also suppressed the @entity5 growth. The selective accumulation of @entity3703 particles in the @entity5 blood vessels was observed by histological examination. These results suggest that this systemic chemotherapy can effectively control the @entity5 without significant side effects, due to the targeting of magnetic ADR liposomes.

title: Targeted systemic chemotherapy using magnetic liposomes with incorporated @entity632 for XXXX in hamsters.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'primary tumor', 'tumors']

entities_list: @entity3703 :: ('MESH:D052203', 'Chemical') :: ['magnetite']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

answer: @entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']


abstract: Different types of microbial mats developing on the wall on a non-thermal @entity599 freshwater spring have been studied. Both, light and electron microscopy as well as HPLC analysis of photosynthetic pigments revealed their structure and composition. Prokaryotic @entity38 and carotenoids helped in the taxonomical assignment of the main photosynthetic groups. "Inverted position" mats (Mat-I) were dominated by Chromatiaceae; they were located closed to the water outlets (0.3 mM @entity3287 ). "Normal position", that is, cyanobacterial-covered mats (Mat-II and Mat-IV), developed elsewhere on the stone walls at lower @entity3287 concentrations. A third type of mat (Mat-III), covered by chemolithotrophic bacteria, was distinguishable at the water-air interface, strongly attached to the walls of the spring. Up to six physiological types of microorganisms have been recognized: cyanobacteria, Chromatiaceae, purple nonsulfur bacteria. Chlorobiaceae, Chloroflexaceae, and chemolithotrophic bacteria. Cyanobacteria Lyngbya-like, Oscillatoria-like and Pseudanabaena sp. were found. The diversity of Chromatiaceae (six morpho-/pigment types of the genus Chromatium, plus two non identified Chromatiaceae, named PB1 and PB2 were observed) was noticeable. Chemolithotrophic bacteria were represented by the genera Beggiatoa and Thiothrix. Finally, small numbers of @entity8553 and @entity43396 were found in all the studied mats.

title: Structure and composition of freshwater microbial mats from a XXXX spring ("Font Pudosa", NE Spain).

entities_list: @entity43396 :: ('1092', 'Species') :: ['Chlorobium limicola']

entities_list: @entity8553 :: ('MESH:C565779', 'Disease') :: ['Chloroflexus-like bacteria']

entities_list: @entity3287 :: ('CHEBI:26822', 'Chemical') :: ['sulfide']

entities_list: @entity38 :: ('MESH:D002734', 'Chemical') :: ['chlorophylls']

answer: @entity599 :: (MESH:D013455,Chemical) :: ['sulfur']


abstract: OBJECTIVE: To evaluate the clinical and pathologic presentation of mature cystic @entity44 and the trends in management over a 14-year study period. METHODS: Tumor registry data and medical records between January 1, 1975 and December 31, 1989 were analyzed with respect to @entity1 age, @entity5 size, bilaterality, malignant transformation, and treatment. RESULTS: Five hundred seventy-three @entity5 were removed from 517 @entity1 . The median and mean (+/- standard deviation) age was found to be 30 and 32 +/- 11.3 years, respectively. Three hundred ten (60%) of the @entity1 were asymptomatic. The mean @entity5 size was 6.4 +/- 3.5 cm. The bilaterality rate was 10.8%. The rate of torsion was 3.5%; larger @entity5 underwent torsion more frequently than smaller @entity5 (P = .029). The rate of malignant transformation was 0.17%. The mean cyst diameter for @entity1 undergoing cystectomy was 5.7 +/- 2.4 cm; for oophorectomy, 8.0 +/- 4.1 cm; and for hysterectomy, 6.1 +/- 3.8 cm. Oophorectomies were performed for larger @entity5 when compared to cystectomies (P = .01). The number of hysterectomies was stable throughout the study period, whereas the number of oophorectomies decreased and the number of cystectomies increased markedly. Contralateral ovarian biopsy was common (48.5%) early in the study period. By 1989, the biopsy rate was less than 1%. CONCLUSIONS: We found the prevalence rates of symptomatic @entity5 , torsion, and @entity528 to be less than those previously reported by most other investigators. In addition, there has been an important change over the past 14 years in the management of these @entity5 , with an increased tendency for ovarian preservation, as evidenced by the more frequent use of cystectomy and a decrease in contralateral ovarian biopsy.

title: XXXX : a clinicopathologic evaluation of 517 cases and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['malignant degeneration']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'neoplasms']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratomas']

answer: @entity44 :: (MESH:D013724,Disease) :: ['Mature cystic teratoma']


abstract: BACKGROUND: The role of @entity4032 ( @entity4032 ) ablation guided by complex fractionated atrial electrograms (CFAE) in @entity955 ( @entity955 ) has been debated. This study evaluated the spatial distribution of @entity4032 CFAE, the critical sites, and the predictors of successful termination of longstanding persistent @entity955 during @entity4032 ablation. METHODS: A total of 97 @entity1 with persistent @entity955 who received automated detection of CFAE mapping and ablation at the @entity4032 for sustained @entity955 after @entity358 and left atrial (LA) CFAE-guided ablation were analyzed. The @entity955 termination patterns and CFAE areas were analyzed. RESULTS: Forty-eight (49%) @entity1 successfully converted to @entity591 ( @entity591 ) or sinus rhythm (SR) during CFAE-guided ablation at the @entity4032 . Of these, 7 (15%) @entity1 converted directly to SR, and 41 (85%) converted via @entity591 . The crista terminalis (CT) was the most common site for @entity591 conversion during @entity4032 CFAE ablation, followed by the @entity4032 appendage and @entity4032 septum. @entity1 with larger @entity4032 volumes (> 145 mm3) had lower rates of SR or @entity591 conversion during @entity4032 CFAE ablation. @entity1 with @entity955 termination during @entity4032 CFAE ablation had less late recurrence than those without @entity955 termination (P = 0.003). CONCLUSION: A half of @entity1 with persistent @entity955 refractory to LA ablation successfully converted to @entity591 or SR during automated CFAE-guided ablation at the @entity4032 . The most common critical sites for @entity955 termination were the CT and @entity4032 appendage and septum. @entity1 with @entity955 termination during procedure whether LA CFAE only or after @entity4032 CFAE ablation had better outcome with less late recurrence of @entity4710 compared to those without @entity955 termination.

title: The spatial distribution of @entity955 termination sites in the right atrium during complex fractionated atrial electrograms-guided ablation in @entity1 with persistent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4710 :: ('MESH:D013617', 'Disease') :: ['atrial tachyarrhythmia']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['atrial tachycardia', 'AT']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vein isolation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity4032 :: ('MESH:D059446', 'Disease') :: ['RA', 'right atrial']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: BACKGROUND: Angiographic collateral vessel filling is limited to evaluate collateral-dependent myocardium. We hypothesize, that quantitative assessment of regional myocardial function, perfusion and viability with Cardiac Magnetic Resonance (CMR) adds complementary information to angiography of collateralized myocardium. METHODS: CMR was performed in 30 @entity1 with one chronic occluded coronary artery and no further flow limiting @entity850 to assess transmural extend of @entity1188 (TEI), resting perfusion and perfusion during @entity859 -induced @entity450 and @entity1565 ( @entity1565 ) in collateral-dependent and antegradely-perfused myocardium. Collateral vessels were evaluated by angiography and the Rentrop grade (0-3). RESULTS: In 15 @entity1 with < 50% TEI in collateral-dependent myocardium resting perfusion (1.08+/-0.22 ml/min/g), @entity450 (2.21+/-0.73 ml/min/g) and @entity1565 (4.0+/-2.6 mm) were similar to antegradely-perfused myocardium (rest 1.14+/-0.20 and @entity450 2.46+/-0.82 ml/min/g, @entity1565 4.3+/-1.7 mm). In 15 @entity1 with > or = 50% TEI in collateral-dependent myocardium resting perfusion and @entity450 as well as @entity1565 were significantly lower (rest 0.84+/-0.19, p<0.001 and @entity450 1.34+/-0.43 ml/min/g, p<0.001; @entity1565 1.0+/-1.0 mm, p<0.0001) compared to antegradely-perfused myocardium. There was an inverse correlation between TEI and resting or hyperemic perfusion or @entity1565 . In contrary, resting perfusion and @entity450 as well as @entity1565 in collateral-dependent myocardium were not different between @entity1 with good (2-3) compared to @entity1 with poor Rentrop grade (0-1). There was no correlation between TEI and Rentrop grade. CONCLUSION: Function and perfusion in collateral-dependent myocardium are preserved, if transmural extent of @entity1188 is limited (< 50%). This is independent of their angiographic collateral vessel filling. Thus, CMR adds complementary information to angiographic standard assessment of collateral vessels.

title: Assessment of collateralized myocardium with Cardiac Magnetic Resonance (CMR): transmural extent of XXXX but not angiographic collateral vessel filling determines regional function and perfusion in collateral-dependent myocardium.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity1565 :: ('MESH:D056151', 'Disease') :: ['RWT', 'regional wall thickening']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['infarction']


abstract: Protein phosphatases, in coordination with protein kinases, play crucial roles in regulation of signaling pathways. To identify protein @entity669 phosphatases (PTPs) and @entity563 - @entity1889 (ser-thr) phosphatases in the @entity6798 genome, 179 annotated sequences were studied (122 PTPs, 57 ser-thr phosphatases). Sequence analysis identified 91 phosphatases (33 conventional PTPs, 31 dual specificity phosphatases, 1 Class III @entity462 -based PTP, 1 @entity2574 -based PTP, and 25 ser-thr phosphatases). Using catalytic sites, levels of conservation and constraint in @entity535 sequence were examined. Nine of 25 receptor PTPs (RPTPs) corresponded to @entity1 , @entity2199 , or @entity238 homologues. Domain structure revealed that sea urchin-specific RPTPs including two, PTPRLec and PTPRscav, may act in immune defense. Embryonic transcription of each phosphatase was recorded from a high-density oligonucleotide tiling microarray experiment. Most RPTPs are expressed at very low levels, whereas nonreceptor PTPs (NRPTPs) are generally expressed at moderate levels. High expression was detected in MAP kinase phosphatases (MKPs) and numerous ser-thr phosphatases. For several expressed NRPTPs, MKPs, and ser-thr phosphatases, morpholino antisense-mediated knockdowns were performed and phenotypes obtained. Finally, to assess roles of annotated phosphatases in endomesoderm formation, a literature review of phosphatase functions in model organisms was superimposed on sea urchin developmental pathways to predict areas of functional activity.

title: Protein @entity669 and XXXX - @entity1889 phosphatases in the sea urchin, @entity6798 : identification and potential functions.

entities_list: @entity462 :: ('MESH:D003545', 'Chemical') :: ['Cysteine']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity6798 :: ('7668', 'Species') :: ['Strongylocentrotus purpuratus']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity563 :: (CHEBI:17822,Chemical) :: ['serine']


abstract: Repair processes of cells submitted to an injury may exhibit an indirect identifying feature of its activity, based on the amount of connective tissue that could be traced with special stains and morphometry. @entity720 concentration in tissue is also an index with which the presence and amount of repair mechanisms can be assessed. They may be quantitated appropriately in correlation with the end products of collagen, which represent the amount of cicatricial tissue. In order to correlate the size of the scar in @entity583 with the amount of connective tissue, a determination of @entity720 levels after 30 days of acute experimental @entity1188 was performed in 3 groups of @entity35 : 10 received a single dose of 2I U of @entity1 @entity2124 (HGH) per week for 4 weeks, in a bolus injection immediately after the @entity1188 was surgically induced; 10 received the same dose as above in daily injections during a week. Finally, another group of 10 animals which did not receive an active treatment served as controls. All animals were sacrificed at the end of a month. A morphometric study with Van Gieson stain was performed. @entity720 levels were determined. @entity720 levels were considerably lower in hGH-treated @entity35 (T) compared to control (C) @entity35 : 3.30 ug/mg +/- 0.1 vs. 4.10 +/- 0.29 (p < 0.05). Morphometry: T.: 5.23 +/- 2.45 vs. C.: 4.22 +/- 2.15 of the left ventricular wall. Three @entity439 were found in C group versus 1 in T. @entity1 @entity2124 administered to a group of @entity35 with @entity583 showed obvious dose--effects consisting of a significant diminution of scar tissue in treated @entity35 with a proportional fall in the @entity720 levels.

title: Reduced injury and scar in acute @entity583 treated with XXXX @entity2124 .

entities_list: @entity720 :: ('CHEBI:18095', 'Chemical') :: ['Hydroxyproline', 'hydroxyproline']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions', 'infarction']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarcts', 'myocardial infarction']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Introduction. An antrolith is a calcified mass within the maxillary sinus. The origin of the nidus of @entity730 may be extrinsic (foreign body in sinus) or intrinsic (stagnant mucus and fungal ball). Most antroliths are small and asymptomatic. Larger ones may present as @entity1244 with symptoms like @entity158 and discharge. Case Report. We report a case of a 47-year-old lady who presented with heaviness on the left side of the face and loosening of the left 2nd molar tooth since two months. CT scan of the osteomeatal complex and paranasal sinuses showed an opacification of bilateral maxillary sinus and an amorphous area of bone density in the left maxillary sinus. Because of the size of the mass, benign @entity5 were considered in the differential diagnosis. During an endoscopic sinus surgery, it was found to be an antrolith, which was successfully managed by antrostomy and Caldwell-Luc Surgery. Discussion. Antrolith is a rare condition. Rhinoliths are known to invade into the maxillary antrum, but a localised lesion in the antrum is very unusual. A case of an isolated antrolith is presented for its rarity and for differential diagnosis of localised antral disease. Conclusion. Antrolith should be considered as differential diagnosis of @entity5578 .

title: Maxillary antrolith: a rare cause of the recurrent XXXX .

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity5578 :: ('MESH:D010254', 'Disease') :: ['unilateral radio-opaque paranasal sinus lesions']

answer: @entity1244 :: (MESH:D012852,Disease) :: ['sinusitis']


abstract: The heterogeneous cell population in primary adipose-derived adult stem cells (ADAS) and difficulty in keeping their primitive properties have posed certain limitations on using these cells for cell therapy. Therefore, our objective was to generate a population of cells enriched from the adipose stromal-vascular fraction (SVF) with greater differentiation potential than ADAS and to explore the mechanism behind the repair of the injured @entity1562 in vivo. The distinct population of adipose stromal cells was enriched by immediate treatment of the @entity2140 cocktail (EGF and PDGF-BB) to the freshly isolated SVF. These cells (ADAS-GFs) had distinct cell morphology from ADAS and in average had a smaller size. They presented co-expression of CD140a (pericytic markers) and @entity6098 (hematopoietic marker), more obvious mesenchymal (CD13, CD29, @entity3802 , @entity18715 and CD117) markers, but rare @entity12186 , and were negative for @entity1008 and @entity18518 . ADAS-GFs not only spontaneously expressed endothelial cell markers and formed capillary-like tubes on Matrigel but also clearly expressed early cardiomyocyte marker genes when embedded in methylcellulose-based medium. In Sprague-Dawley (SD) @entity35 with left anterior descending artery (LAD)-induced @entity583 ( @entity583 ), the ADAS-GFs transplanted group had the left ventricular function significantly improved compared with the ADAS transplanted group or the control group at 12 weeks post transplantation. The immunofluorescence staining revealed that the transplanted ADAS-GFs expressed @entity28430 , @entity6144 and troponin T protein but not @entity25042 . More capillaries were also observed around the infarcted zone in the ADAS-GFs transplanted group. These data suggested that ADAS-GFs with a higher proangiogenic potential may restore the cardiac function of infarcted @entity1562 via the direct cardiomyocyte differentiation as well as angiogenesis recruitment.

title: Primary adipose-derived stem cells enriched by XXXX treatment improves cell adaptability toward cardiovascular differentiation in a rodent model of @entity583 .

entities_list: @entity6144 :: ('29557(Tax:10116)', 'Gene') :: ['betamyosin heavy chain']

entities_list: @entity1562 :: ('MESH:D017682', 'Disease') :: ['myocardium']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

answer: @entity2140 :: (79215(Tax:10116),Gene) :: ['growth factor']


abstract: OBJECTIVE: To evaluate the prognostic role of the ratio between @entity75 and liver SUVmax (rPET) in @entity1 with @entity978 ( @entity978 ) undergoing interim FDG-PET/CT and to compare rPET with the 5-point Deauville Score (5p-DS). METHODS: Sixty-eight @entity1 with @entity978 undergoing interim FDG-PET/CT after first courses of chemotherapy were evaluated. The receiver operating characteristic (ROC) approach was applied to identify the optimal cutpoint of rPET with respect to progression free survival (PFS). The prognostic significance of rPET was compared with 5p-DS (scores 4 and 5 considered as positive). Positive predictive value ( @entity2286 ) and negative predictive value (NPV) were calculated using the presence of an adverse event as the gold standard. RESULTS: The ROC analysis for rPET as a predictor of progression showed an optimal rPET cutpoint of 1.14. Both 5p-DS and rPET were strong outcome predictors (p  <  0.001). @entity1 with negative 5p-DS and @entity1 with rPET <1.14 had a similar two-year PFS (86 and 87  %, respectively). @entity1 with a positive 5p-DS had a 2-year PFS of 27  %, while @entity1 with rPET >1.14 had a 2-year PFS of 15  %. 5p-DS and rPET cutoff of 1.14 showed a @entity2286 of 58 versus 70  %, and a NPV of 85 versus 86  %, respectively. CONCLUSIONS: rPET could be considered an accurate prognostic factor in @entity1 with @entity978 undergoing interim FDG-PET/CT. Larger prospective studies are needed to confirm these data.

title: Interim FDG-PET/CT in XXXX : the prognostic role of the ratio between @entity75 and liver SUVmax (rPET).

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['target lesion']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', 'Hodgkin lymphoma']

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin lymphoma']


abstract: UNASSIGNED: There is growing evidence that heightened sensitivity to unpredictability is a core mechanism of @entity148 . In adults, multiple @entity148 have been associated with a heightened @entity427 reflex in anticipation of unpredictable threat. @entity1 and adolescent @entity148 has been linked to an increased @entity427 reflex across baseline, safety, and threat conditions. However, it is unclear whether @entity148 in youth is related to the @entity427 reflex as a function of threat predictability. In a sample of 90 8 to 14  year-old @entity1 , the present study examined the association between @entity148 symptom dimensions and @entity427 potentiation during a no, predictable, and unpredictable threat task. @entity308 symptom dimensions were also examined given their high comorbidity with @entity148 and mixed relationship with the @entity427 reflex and sensitivity to unpredictability. To assess current symptoms, @entity1 completed the self-report Screen for @entity1 @entity148 and @entity1 's @entity308 Inventory. Results indicated that @entity913 were associated with heightened @entity427 potentiation in anticipation of unpredictable threat and attenuated @entity427 potentiation in anticipation of predictable threat. Negative mood and negative self-esteem symptoms were associated with attenuated and heightened @entity427 potentiation in anticipation of unpredictable threat, respectively. All results remained significant after controlling for the other symptom dimensions. The present study provides initial evidence that @entity148 and @entity308 symptom dimensions demonstrate unique associations with the @entity427 reflex in anticipation of unpredictable threat in @entity1 and adolescents.

title: XXXX and @entity308 Symptom Dimensions Demonstrate Unique Relationships with the Startle Reflex in Anticipation of Unpredictable Threat in 8 to 14  Year-Old @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Child', 'children', 'Children', 'girls']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity913 :: ('MESH:D010698', 'Disease') :: ['social phobia symptoms']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'Anxiety Related Emotional Disorders', 'anxiety disorders']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety']


abstract: OBJECTIVES: Arterial stiffening and @entity409 are hallmarks of aging, and advanced glycation endproducts (AGE) may contribute to these changes. We tested the hypothesis that AGE crosslink breakers enhance endothelial @entity384 ( @entity384 ) in @entity1 and examined the potential mechanisms for this effect. METHODS: Thirteen adults (nine @entity1 , aged 65 +/- 2 years) with isolated systolic @entity101 (systolic blood pressure > 140 mmHg, diastolic blood pressure < 90 mmHg or pulse pressure > 60 mmHg) on stable antihypertensive therapy were studied. Subjects received placebo (2 weeks) then oral @entity39912 ( @entity39912 ; 210 mg twice a day for 8 weeks). Subjects and data analyses were blinded to treatment. Arterial stiffness was assessed by carotid augmentation index (AI) and @entity432 distensibility (ArtD) using applanation tonometry and Doppler echo, and endothelial function by @entity384 . Serum markers of collagen metabolism and vascular @entity32 were assessed. RESULTS: Alagebrium reduced carotid AI by 37% (P = 0.007) and augmented pressure (16.4 +/- 10 to 9.6 +/- 9 mmHg; P < 0.001). Heart rate, arterial pressures, and ArtD, were unchanged. @entity384 increased from 4.6 +/- 1.1 to 7.1 +/- 1.1% with alagebrium (P < 0.05), and was unrelated to altered shear stress or regional arterial distensibility. However, @entity384 change was inversely related to markers of collagen synthesis, @entity8729 and intracellular cell adhesion molecule (all P < 0.05). Alagebrium-associated changes in plasma @entity3542 plus @entity1507 was inversely correlated with plasma matrix metalloproteinase 9 and type I collagen (P = 0.007). CONCLUSIONS: Alagebrium enhances peripheral artery endothelial function and improves overall impedance matching. Improved endothelial function correlates better with reduced vascular @entity82 and @entity32 markers than with vessel distensibility. AGE-crosslink breakers may reduce cardiovascular risk in older adults by reduced central arterial stiffness and @entity6980 .

title: Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in @entity1 with isolated systolic XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'brachial FMD', 'FMD']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity6980 :: ('MESH:D066253', 'Disease') :: ['vascular remodeling']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['brachial artery']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: @entity296 is a consequence of @entity1555 ( @entity1555 ). Suggested treatments include angiotensin-converting enzyme ( @entity1289 ) inhibitors and/or b blockers (BBs), but few large series have been reported. We present 42 @entity1 with @entity1555 and @entity296 treated with an @entity1289 inhibitor or an @entity1289 inhibitor plus a BB. Serial echocardiograms were recorded. Adequate ejection fractions (EFs) were obtained at initiation of therapy (EF <55%). @entity1289 inhibitor dosage adjustments were made if a continued decrease in EF was noted. BB therapy was initiated when average heart rate on Holter monitoring exceeded 100 beats/min. Data were analyzed using paired t test and linear regression. Before @entity1289 inhibition, @entity1 (n = 22) demonstrated decreased EF over time (r(2) = 0.23). At @entity1289 inhibitor therapy initiation, mean age was 14.1    4.6 years and mean EF was 44.2    6.8%. BB therapy was used in 24 of 42 @entity1 . Mean age for the @entity1289 inhibitor + BB group was 15.7    3.9 years. The 2 groups showed significant improvement (p <0.0001 for @entity1289 inhibitor and @entity1289 inhibitor plus BB) compared to the pretherapy group. No significant differences were noted between treatment groups. @entity1 with @entity1555 demonstrated a gradual decrease in myocardial function. Treatment with @entity1289 inhibitor or @entity1289 inhibitor plus BB resulted in significant improvement compared to pretherapy. No significant difference occurred in EF improvement between treatment groups. In conclusion, treatment with @entity1289 inhibitor or @entity1289 inhibitor plus BB can delay progression of @entity296 .

title: Effects of angiotensin-converting enzyme inhibitors and/or beta blockers on the @entity296 in XXXX .

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne muscular dystrophy', 'DMD']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'Cardiomyopathy']

answer: @entity1555 :: (MESH:D020388,Disease) :: ['Duchenne muscular dystrophy']


abstract: UNASSIGNED: A prolonged period of T-cell recovery is the major challenge in hematopoietic stem cell transplantation (HSCT). Thymic epithelial cells (TECs) are the major component of the thymic microenvironment for T-cell generation. However, TECs undergo degeneration over time. @entity31125 plays a critical role in TEC development and is required to maintain adult TECs for thymopoiesis. To investigate the potential application of @entity31125 , we have cloned and expressed recombinant @entity31125 protein ( @entity27985 ) that was fused with cell-penetrating peptides. We show that the @entity27985 protein can translocate from the cell surface into the cytoplasm and nucleus. Administration of @entity27985 into both congenic and allogeneic HSCT recipient @entity19 increased the number of TECs, resulting in enhanced thymopoiesis that led to an increased number of functional T-cells in the periphery. The increased number of TECs is due to the enhanced survival and proliferation of TECs. Our results suggest that @entity27985 has the potential to be used in enhancing T-cell regeneration in @entity1 following HSCT. This article is protected by copyright. All rights reserved.

title: @entity31125 recombinant protein enhances T-cell regeneration after hematopoietic stem cell transplantation in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: @entity1821 is a very rare @entity5 that often causes nonspecific clinical symptoms, such as progressive @entity1282 , @entity1109 . The combination of radiological imaging techniques and histopathological analysis provides information for diagnosis; however, the pathogenesis is still uncertain. CASE PRESENTATION: A 30-year-old male @entity1 presented with a pharyngeal cavity mass, which had been present for 2 years. The clinical syndrome included @entity27 (i.e., respiratory disturbances, excessive daytime somnolence, and @entity10 ) and @entity1282 . The radiological examination (CT) demonstrated that there was a low-density irregular solid lesion on the posterior wall of the oropharynx and laryngopharynx, which descended to the superior mediastinum and extended to the left parapharyngeal space and sternocleidomastoid muscle. The boundaries of the lesion were clear, and the lesion's density was nonuniform. Several septations inside the lesion were observed. The CT values of the lesion at the @entity2582 and the vocal folds were 11 HU and minus 30 HU, respectively. After enhanced scanning, there was no apparent enhancement of the lesion: the surrounding tissue and blood vessels were squeezed and shifted, but the neighboring sclerotin of the cervical vertebrae was not invaded. The mass was removed via a transcervical approach, resulting in a complete amelioration of the @entity1 's symptoms. Interestingly, immunohistochemistry showed that the @entity5 cells expressed members of the B7 superfamily, including B7-H1, @entity14797 and B7-H3. In addition, the expression of @entity34705 -containing molecules, including @entity20500 and @entity40094 , was observed. CONCLUSIONS: CT and MRI demonstrated that the mass was a @entity1821 . Furthermore, @entity189 -associated B7 and @entity34705 -containing molecules were observed in the tissue, indicating that these molecules are most likely active in the pathogenesis of this disease. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1907794973876202.

title: XXXX : a case report.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['globus sensation and/or respiratory disturbances']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea symptoms']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['difficulty swallowing', 'dysphagia']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1821 :: ('MESH:D008080', 'Disease') :: ['Parapharyngeal liposarcoma', 'parapharyngeal liposarcoma']

entities_list: @entity2582 :: ('MESH:C537690', 'Disease') :: ['epiglottis']

answer: @entity1821 :: (MESH:D008080,Disease) :: ['Parapharyngeal liposarcoma']


abstract: OBJECTIVE: Information on the relationships between stool characteristics and @entity694 ( @entity694 ) in @entity1744 ( @entity1744 ) is limited. Our aims were: (i) to relate stool frequency and consistency to total and segmental CTTs, (ii) to correlate changes in these stool characteristics with changes in CTTs between a baseline assessment and a 12-week assessment, and (iii) to examine the confounding effects of mood on these relationships, in @entity1 with @entity1744 . MATERIALS AND METHODS: Twenty-one female @entity1 with @entity1744 underwent, on two occasions 12 weeks apart, a colonic transit study and completed at these times Bristol Stool Form Scale (BSFS) and Bowel Symptoms Severity Rating Scale (BSSRS). All @entity1 also completed the Hospital Anxiety and @entity308 scale. RESULTS: Between baseline and the 12-week assessment, an increase in the number of days over the past week without a bowel motion correlated with prolonged total @entity694 (r = 0.54, p = 0.01). An increase in the number of days with more than three bowel motions per day correlated with a shorter right @entity694 (r = -0.52, p = 0.02). Only after adjusting for @entity148 and @entity308 , did an increase in loose or watery bowel motions (for BSSRS but not for BSFS) correlate with a shorter right @entity694 (r = -0.47, p = 0.03). CONCLUSIONS: Stool frequency, as well as stool consistency, correlates with @entity694 . Correlations between stool consistency and @entity694 are more robust for BSSRS than for BSFS. An effect of mood appears to be important in the relationship between stool consistency and @entity694 .

title: Stool characteristics and colonic transit in XXXX : evaluation at two time points.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic transit time', 'CTT']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome', 'IBS']

answer: @entity1744 :: (MESH:D043183,Disease) :: ['irritable bowel syndrome']


abstract: The herbal ingredients of @entity39482 and @entity39483 were isolated from Dactylicapnos scandens. This study was aimed at developing a liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI- @entity15 / @entity15 ) method to quantify @entity39482 and @entity39483 in @entity35 plasma and tissues for pharmacokinetic, tissue distribution and excretion studies. Biological samples were processed with @entity1046 extraction, and @entity39484 was chosen as the internal standard (IS). The analytes were separated by a C(18) column and detected with a triple quadrupole mass spectrometer using positive ion ESI in the multiple reaction monitoring (MRM) mode. The @entity15 / @entity15 ion transitions monitored were m/z 342.0 > 278.9 for @entity39482 , 354.1 > 188.0 for @entity39483 and 370.0 > 192.0 for IS, respectively. Excellent linearity was observed over the concentration range between 10 and 3000 ng/mL for @entity39482 and 10-300 ng/mL for @entity39483 . The lower limit of quantification (LLOQ) was 10 ng/mL for both @entity39482 and @entity39483 . This novel method was rapid, accurate, high sensitive and high selective. It was successfully applied to the pharmacokinetic, tissue distribution and excretion studies of D. scandens. These preclinical data of D. scandens would be useful for the clinical reference.

title: Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of Dactylicapnos scandens in XXXX .

entities_list: @entity39484 :: ('MESH:C452799', 'Chemical') :: ['corydaline']

entities_list: @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate']

entities_list: @entity39482 :: ('MESH:C030168', 'Chemical') :: ['isocorydine']

entities_list: @entity39483 :: ('MESH:C009093', 'Chemical') :: ['protopine']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: To analyze the cranial distribution of level II lymph nodes in @entity1 with @entity5 to optimize the elective radiation nodal target volume delineation. METHODS AND MATERIALS: The most cranially located metastatic lymph node was delineated in 67 diagnostic CT data sets. The minimum distance from the @entity1297 ( @entity1297 ) to the lymph node was determined. RESULTS: A total of 98 lymph nodes were delineated including 62 ipsilateral and 36 contralateral lymph nodes. The mean ipsilateral and contralateral distance from the top of the most cranial metastatic lymph node to the @entity1297 was 36 mm (range, -9-120; standard deviation [SD], 17.9) and 35 mm (range, 14-78; SD 15.0), respectively. Only 5% and 12% of the ipsilateral and 3% and 9% of the contralateral metastatic lymph nodes were located within 15 mm and 20 mm below the @entity1297 , respectively. No significant differences were found between @entity1 with only ipsilateral metastatic lymph nodes and @entity1 with bilateral metastatic lymph nodes. Between @entity5 that do cross the midline and those that do not, no significant difference was found in the distance of the most cranial lymph node to the @entity1297 and the occurrence ipsilateral or contralateral. CONCLUSIONS: Setting the cranial border of the nodal target volume 1.5 cm below the @entity1297 covers 95% of the lymph nodes and should be considered in elective nodal irradiation for @entity5 . @entity135 irradiation is mandatory, including @entity1 with unilateral @entity5 , when elective irradiation is advised.

title: Cranial location of level II lymph nodes in XXXX : Implications for elective nodal target volume delineation.

entities_list: @entity1297 :: ('MESH:D019292', 'Disease') :: ['base of the skull', 'BOS']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['Bilateral neck']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['laryngeal cancer']


abstract: BACKGROUND: Telomere signaling plays a role in regulating cardiomyocyte apoptosis during @entity299 . In this study, we investigated the effects of @entity3089 ( @entity3090 ), the major component of @entity6398 in green tea, on telomere dependent apoptotic signal in pressure overload @entity1283 . METHODS AND RESULTS: @entity1283 in @entity35 was established by abdominal aortic constriction (AC). @entity3090 50, 100 mg/kg, @entity3092 (Que) 100mg/kg, @entity3371 (Cap) 50mg/kg, @entity9886 (Los) 30 mg/kg and @entity1405 (Carv) 30 mg/kg was intragastrically administered for 6 weeks. Three, five and 7 weeks after aortic constriction, the heart weight indices increased progressively. @entity1234 ( @entity1865 ) contents progressively increased, while @entity224 dismutase (SOD) activities decreased. Progressive cardiomyocyte apoptosis and telomere @entity6661 were also found. Although no significant alteration of @entity25668 ( @entity25668 ) mRNA was found till 7 weeks after aortic constriction, progressive upregulation of @entity10740 , @entity4569 and downregulation of @entity1976 , telomere repeat-binding factor 2(TRF(2)) were seen. @entity3090 , @entity3092 , @entity3371 , @entity9886 and @entity1405 markedly reduced heart weight indices and apoptotic cardiomyocyte in @entity1184 , but they had different effects on apoptotic related proteins @entity1976 , @entity10740 and @entity4569 . @entity3090 , @entity3092 and @entity1405 , have potent antioxidant effects as evidenced by reduction of @entity1865 contents and resumption of SOD activities. @entity3090 , @entity3092 and @entity1405 could prevent telomere @entity6661 and telomere repeat-binding factor 2 (TRF(2)) loss remarkably, whereas @entity3371 and @entity9886 had no effect on oxidative stress and telomere signal. CONCLUSIONS: Pressure overload induced @entity1283 initiates oxidative stress, induces telomere repeat-binding factor 2 loss and accelerates telomere @entity3207 in @entity1184 . @entity3090 , @entity3092 and @entity1405 with potent antioxidant effect, may inhibit cardiac myocyte apoptosis by preventing telomere @entity3207 and telomere repeat-binding factor 2 (TRF(2)) loss.

title: XXXX , the major component of @entity6398 in green tea, inhibits telomere @entity6661 mediated cardiomyocyte apoptosis in @entity1283 .

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic myocardium']

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy', 'Cardiac hypertrophy']

entities_list: @entity3371 :: ('CHEBI:3380', 'Chemical') :: ['captopril']

entities_list: @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin gallate']

entities_list: @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan']

entities_list: @entity1405 :: ('MESH:C043211', 'Chemical') :: ['carvedilol']

entities_list: @entity6661 :: ('MESH:D019217', 'Disease') :: ['attrition']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde']

entities_list: @entity3092 :: ('MESH:D011794', 'Chemical') :: ['quercetin']

entities_list: @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']

entities_list: @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity25668 :: ('301965(Tax:10116)', 'Gene') :: ['TERT', 'telomerase reverse transcriptase']

answer: @entity3089 :: (MESH:C045651,Chemical) :: ['Epigallocatechin gallate']


abstract: Treatment of @entity157 depends largely on local resources, the stage of the disease and the presence of @entity82 , but is limited overall by the lack of efficient chemotherapy. Hepatic resection is the treatment of choice for the few @entity1 with @entity157 and normal liver. Five-year survival without recurrence in @entity1 with a @entity5 of mean diameter 8 cm was 33%. Liver transplantation is the best chance for cure in @entity1 with @entity82 and a single small @entity5 , but its widespread application is limited by a number of obstacles, including cost. @entity5 size and number, and liver status were common guidelines for selecting @entity1 . Five-year survival of transplant @entity1 was > 50%, compared to 0% in historical untreated controls. @entity1 with well-preserved liver function and a small @entity5 at the periphery could equally benefit from hepatic resection, although @entity82 entails the risk of morbidity due to portal @entity101 and development of de-novo @entity5 . Another major drawback of hepatic resection is the early spread of @entity5 cells, facilitating early @entity5 recurrence after operation. For @entity1 with compensated @entity82 and a small @entity5 who were hardly eligible for surgery, transcatheter arterial chemoembolization appeared to be a cost-saving and effective treatment modality. Transcatheter arterial chemoembolization has been largely employed also for the palliative treatment of @entity1 with large @entity5 , but the benefits on survival are doubtful. Conventional radiotherapy with external irradiation was not effective against @entity157 .

title: Nonpercutaneous therapies of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: This paper is concerned with the causes of @entity2208 in a sample of 200 pregnancies induced by artificial insemination. In particular it examines the importance of the following factors: existing disorders in the @entity1 's menstrual cycle, the influence of hormone treatment during the conception cycle, the age of the @entity1 treated, and the type of semen used. Of the 200 pregnancies in our treatment sample 27 terminated in abortions (13.5%). Clinical examination before treatment established the presence of @entity1866 in 69 of 180 @entity1 to be treated: 23.9% exhibited @entity42 , 12% anovular cycles, and 2% @entity2589 . On the basis of this preliminary examination the principal cause of abortion proved to be an existing @entity42 , since 15 of the 27 abortions occurred in @entity1 with this type of @entity1866 . Our observations show that it is important when performing artificial insemination to correct the @entity1 's existing @entity1866 by means of hormone treatment. This emerges from the following figures: In 26 cases without hormone treatment the incidence of abortion was 35%. In 174 cases that received hormone treatment during the successful cycle only 18 abortions occurred (an incidence of 10.3%). Breaking down hormone treatment into 6 basic types, we get incidences of abortion ranging from 0 to 25% in the different groups. Dividing the treatment sample into age groups reveals an 11 to 14% incidence of abortion in the 30 to 34 age group; in the 35 to 40 group age group the incidence doubles to 26%. Whereas existing @entity1866 and adequate hormone treatment significantly influence the incidence of abortion, there is no close relationship between incidence of abortion and the type of semen used. The innocuousness of using deep-frozen semen with an admixture of @entity653 has been shown by various authors reporting on laboratory and clinical investigations. For 117 pregnancies induced purely with deep-frozen semen we had an incidence of abortion of 13.7%. This figure is of the same order as the incidence of abortion in pregnancies induced by insemination with fresh semen. The results obtained permit one to conclude that incidence of abortion is not significantly dependent on the type of semen used. Our work demonstrates the importance of assessing the @entity1 's genital constitution from both the functional and the organic points of view, not merely in order to achieve conception but also for the purposes of preventing abortion by means of the appropriate hormone treatment. If satisfactory therapeutic results are to be achieved candidates for artificial insemination must therefore be given a thorough diagnostic examination beforehand and, if necessary, adequate hormone treatment during the insemination cycle.

title: [The frequency and causes of XXXX following artifitial insemination (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patient']

entities_list: @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerine']

entities_list: @entity42 :: ('MESH:D010048', 'Disease') :: ['corpus luteum deficiency']

entities_list: @entity1866 :: ('MESH:D008599', 'Disease') :: ['menstrual disorders', 'menstrual disorder']

entities_list: @entity2589 :: ('MESH:D009839', 'Disease') :: ['oligomenorrhea']

answer: @entity2208 :: (MESH:D000022,Disease) :: ['spontaneous abortion']