abstract: A comparison was made of the results obtained in separate Phase I studies conducted in Japan on a recombinant @entity1956 vaccine (HBX-R) and a plasma-derived @entity1956 vaccine ( @entity17128 ). Recombinant @entity1956 vaccine was administered intramuscularly (IM) to 40 subjects in a dose of 10 micrograms, while @entity17128 was administered IM to 35 subjects in a dose of 20 micrograms. Each subject received three doses of the vaccine at times zero, 1 month and 6 months. In both trials, at the end of 7 months from the first vaccination all vaccinees had become seropositive for anti-HBs antibody. During the 1-6 month period after the first dose, the seroconversion rate was always higher in the @entity17128 subjects than in the HBX-R subjects. The anti-HBs antibody titre was also always higher in the @entity17128 group during that same 6-month period, but there was no longer any difference at the 7th month ( @entity17128 : HBX-R = 1064: 1164 IU/L). In an additional study on the effect of the administration route on the efficacy of HBX-R, 124 subjects were randomly allotted to an IM group and a subcutaneous (sc) group. In each group, HBX-R was administered in 3 doses of 10 micrograms, again at time zero, 1 month and 6 months. At the end of the 7th month, the anti-HBs seroconversion rates were 98% (55/56) in the IM group and 97% (57/59) in the sc group.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Comparison of results for phase I studies with recombinant and plasma-derived XXXX vaccines, and controlled study comparing intramuscular and subcutaneous injections of recombinant @entity1956 vaccine.

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

answer: @entity1956 :: (MESH:D006509,Disease) :: ['hepatitis B']


abstract: STUDY DESIGN: Research update, focused review. OBJECTIVE: Identify the role of the pelvis in the setting of adults with @entity85 . SUMMARY OF BACKGROUND DATA: Sagittal plane alignment is increasingly recognized as a critical parameter in the setting of adult @entity85 . Additionally, pelvic parameters reveal to be a key component in the regulation of sagittal alignment. METHODS: Analysis of the pelvis in the sagittal plane is commonly assessed by 3 angular measurements: the pelvic incidence (morphologic parameter directly linked to sagittal morphotypes), the pelvic tilt (or pelvis retroversion used to maintain an upright posture in the setting of @entity85 ), and the sacral slope. Recent work using force plate technology has revealed that in the setting of anterior trunk inclination ("spinal imbalance"), the pelvis shifted posteriorly (toward the heels) in order to maintain a balanced mass distribution. The complex relationship between pelvic and spinal parameter were investigated in order to construct predictive formulas of postoperative spinopelvic alignment. It has emerged that pelvic tilt is highly correlated with @entity1 self reported function (ODI, SF-12, and @entity6815 ). CONCLUSION: It has become evident that good clinical outcome in the treatment of @entity85 requires proper alignment. Pelvis parameters play an essential role not only in terms of spine morphotypes but also in regulating standing balance and postoperative alignment. Thus, optimal treatment of a @entity1 with @entity85 requires integration of the pelvis in the preoperative evaluation and treatment plan.

title: Sagittal plane considerations and the pelvis in the adult XXXX .

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['spinal deformity']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: Trypanosomatids' @entity535 permeases are key proteins in parasite metabolism since they participate in the adaptation of parasites to different environments. Here, we report that TcAAP3, a member of a @entity1527 multigene family of permeases, is a bona fide @entity369 transporter. Most higher eukaryotic cells incorporate cationic @entity1522 through a single transporter. In contrast, @entity1527 can recognize and transport cationic @entity1522 by mono-specific permeases since a 100-fold molar excess of @entity376 could not affect the @entity369 transport in parasites that over-express the @entity369 permease (TcAAP3 epimastigotes). In order to test if the permease activity regulates downstream processes of the @entity369 metabolism, the expression of the single @entity1527 enzyme that uses @entity369 as substrate, @entity369 kinase, was evaluated in TcAAP3 epimastigotes. In this parasite model, intracellular @entity369 concentration increases 4-folds and @entity855 level remains constant until cultures reach the stationary phase of growth, with decreases of about 6-folds in respect to the controls. Interestingly, Western Blot analysis demonstrated that @entity369 kinase is significantly down-regulated during the stationary phase of growth in TcAAP3 epimastigotes. This decrease could represent a compensatory mechanism for the increase in @entity855 consumption as a consequence of the displacement of the reaction equilibrium of @entity369 kinase, when the intracellular @entity369 concentration augments and the @entity413 from the medium is exhausted. Using immunofluorescence techniques we also determined that TcAAP3 and the specific @entity376 transporter TcAAP7 co-localize in a specialized region of the plasma membrane named flagellar pocket, staining a single locus close to the flagellar pocket collar. Taken together these data suggest that @entity369 transport is closely related to @entity369 metabolism and cell energy balance. The clinical relevance of studying trypanosomatids' permeases relies on the possibility of using these molecules as a route of entry of therapeutic drugs.

title: Cationic @entity535 uptake constitutes a metabolic regulation mechanism and occurs in the flagellar pocket of XXXX .

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity1527 :: ('5693', 'Species') :: ['Trypanosoma cruzi', 'T. cruzi']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity1527 :: (5693,Species) :: ['Trypanosoma cruzi']


abstract: @entity463 is the most aggressive type of malignant @entity1 @entity1313 . Molecular profiling experiments have revealed that these @entity5 are extremely heterogeneous. This heterogeneity is one of the principal challenges for developing targeted therapies. We hypothesize that despite the diverse molecular profiles, it might still be possible to identify common signaling changes that could be targeted in some or all @entity5 . Using a network modeling approach, we reconstruct the altered signaling pathways from @entity5 -specific phosphoproteomic data and known protein-protein interactions. We then develop a network-based strategy for identifying @entity5 specific proteins and pathways that were predicted by the models but not directly observed in the experiments. Among these hidden targets, we show that the @entity12363 ( @entity12363 ) displays increased phosphorylation in all @entity5 . By contrast, protein @entity21129 homolog ( @entity21129 ) is present only in the subset of the @entity5 that are the most invasive. Additionally, increased @entity12848 is associated with only one of the @entity5 . Overall, our results demonstrate that despite the heterogeneity of the proteomic data, network models can identify common or @entity5 specific pathway-level changes. These results represent an important proof of principle that can improve the target selection process for @entity5 specific treatments.

title: Network Modeling Identifies XXXX -specific Pathways in @entity463 .

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['Glioblastoma']

entities_list: @entity12363 :: ('5604', 'Gene') :: ['ERK activator kinase1', 'MEK1']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: Two studies explore the relationship between @entity1021 and behavioral @entity308 . @entity146 was induced using inescapable footshock, and assessed by measuring subsequent responses to escapable @entity1457 , in @entity35 housed under different light-dark conditions. Experiment 1 compared escape performance in free-running and entrained animals following inescapable @entity1457 . Free-running and entrained animals did not exhibit differential vulnerability to the effects of inescapable @entity1457 . In addition, there were no systematic effects on phase following @entity1457 . However, several free-running animals showed increased circadian period following @entity1457 , and lengthening of period was significantly correlated with escape performance. Individual differences in baseline period or phase were not predictive of escape performance. In Experiment 2, "aftereffects" of entrainment to long or short light-dark cycles were utilized to create groups of animals with long or short free-running periods. After the administration of inescapable @entity1457 , escape performance was tested. There were no significant differences among experimental groups in escape performance. These results suggest that plasticity of circadian period, but not baseline period per se, may be associated with the ability to adapt to environmental challenges.

title: Circadian XXXX and behavioral @entity308 : II. Effects of lighting schedules.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Behavioral depression']

entities_list: @entity1021 :: ('MESH:D020922', 'Disease') :: ['rhythmicity']

answer: @entity1021 :: (MESH:D020922,Disease) :: ['rhythmicity']


abstract: @entity9124 and @entity10130 are parasitic @entity2199 living in the small intestine of @entity1 and @entity1707 , and can cause the disease @entity2329 . For long, there has been controversy as to whether the two ascaridoid taxa represent the same species due to their significant resemblances in morphology. However, the complete mitochondrial (mt) genome data have been lacking for A. lumbricoides in spite of @entity1 and animal health significance and socio-economic impact globally of these parasites. In the present study, we sequenced the complete mt genomes of A. lumbricoides and A. suum (China isolate), which was 14,303 bp and 14,311 bp in size, respectively. The identity of the mt genomes was 98.1% between A. lumbricoides and A. suum (China isolate), and 98.5% between A. suum (China isolate) and A. suum (USA isolate). Both genomes are circular, and consist of 36 genes, including 12 genes for proteins, 2 genes for rRNA and 22 genes for tRNA, which are consistent with that of all other species of ascaridoid studied to date. All genes are transcribed in the same direction and have a @entity377 composition high in A and T (71.7% for A. lumbricoides and 71.8% for A. suum). The @entity1129 bias had a significant effect on both the codon usage pattern and @entity535 composition of proteins. Phylogenetic analyses of A. lumbricoides and A. suum using concatenated @entity535 sequences of 12 protein-coding genes, with three different computational algorithms (Bayesian analysis, maximum likelihood and maximum parsimony) all clustered in a clade with high statistical support, indicating that A. lumbricoides and A. suum was very closely related. These mt genome data and the results provide some additional genetic evidence that A. lumbricoides and A. suum may represent the same species. The mt genome data presented in this study are also useful novel markers for studying the molecular epidemiology and population genetics of Ascaris.

title: Comparative analyses of the complete mitochondrial genomes of @entity9124 and @entity10130 from XXXX and @entity1707 .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity2329 :: ('MESH:D001196', 'Disease') :: ['ascariasis']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity9124 :: ('6252', 'Species') :: ['Ascaris lumbricoides']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: The induction of angiogenesis is crucial in the development of most @entity1 @entity5 . Angiogenesis is routinely assessed by the density of @entity5 microvessels. This technique reveals controversial results on the clinical and prognostic value of angiogenesis in @entity320 . We investigated angiogenesis in @entity5 tissues of 58 @entity320 @entity1 , of which a clinical follow-up of over 10 years was available, through assessment of microvessel density and by enumeration of the number of proliferating endothelial cells. To that end, vessels were immunohistochemically detected by @entity2279 / @entity2280 staining, and proliferating endothelial cells were enumerated in a double staining with the proliferation marker Ki67. We found that microvessel density did not correlate with @entity5 stage or survival, neither in intratumoral nor in peritumoral areas. In contrast, proliferating endothelial cells were only observed in intratumoral areas and were correlated positively with @entity5 stage and the presence of distant metastases. In addition, a strong positive correlation was found with the number of proliferating @entity5 cells. Finally, high numbers of growing endothelial cells predicted short survival. Our results show that angiogenesis could best be measured by enumeration of proliferating endothelial cells and that this parameter has prognostic value in @entity1 with @entity320 .

title: Proliferating endothelial cells, but not microvessel density, are a prognostic parameter in @entity1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'cutaneous melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['cutaneous melanoma']


abstract: OBJECTIVE: To recognize @entity299 and @entity4785 in @entity1 receiving extracorporeal membrane oxygenation (ECMO), and to define @entity1 at risk. DESIGN: Retrospective review. SETTING: Tertiary neonatal ICU. @entity1 : Four newborn @entity1 with @entity177 who developed signs of @entity299 and @entity4785 early in the ECMO course. MEASUREMENTS AND MAIN RESULTS: Initially, these @entity1 had @entity520 , chest roentgenograms showing pulmonary granularity and moderate @entity1283 , and symptoms of severe @entity649 . @entity299 was apparent after ECMO was begun, with poor perfusion, pale color, narrow pulse pressure, and @entity591 despite normovolemia. Within 1 to 2 hrs, @entity4785 occurred manifested by the absence of pulse pressure, palpable pulse, cardiac sounds, and apical impulse while on 50% to 70% bypass. All @entity1 survived. INTERVENTIONS: @entity1 received ECMO, @entity10041 , @entity4388 , and @entity452 . CONCLUSIONS: @entity1 with @entity299 have symptoms similar to severe @entity649 , and may require ECMO support. In the ECMO @entity1 , @entity299 and @entity4785 can be confused with low circuit volume, pneumothorax, or @entity2293 . Early recognition of @entity4785 may improve care and outcome. Cardiac stun syndrome can be treated successfully with ECMO.

title: XXXX in newborns treated with extracorporeal membrane oxygenation: an extreme form of @entity299 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity2293 :: ('MESH:D002305', 'Disease') :: ['cardiac tamponade']

entities_list: @entity4785 :: ('MESH:D004213', 'Disease') :: ['electromechanical dissociation']

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiomegaly']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome', 'respiratory distress']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['cardiorespiratory failure']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity10041 :: ('MESH:D002125', 'Chemical') :: ['calcium gluconate']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Cardiac dysfunction', 'cardiac stun syndrome']

answer: @entity4785 :: (MESH:D004213,Disease) :: ['Electromechanical dissociation']


abstract: 40 @entity1 with @entity4710 were allocated to two different treatment groups according to their year of birth. Those @entity1 born on odd years were given 5 mg of @entity6310 intravenously, those born on even years receiving 5 mg of @entity1855 , and if the @entity591 continued, the same injection was repeated after 5 minutes. If @entity6310 treatment failed, the @entity1 was given 5 mg of @entity1855 half an hour later, and vice versa. @entity1855 restored sinus rhythm in 19 @entity1 out of 20. @entity6310 proved effective in 8 out of 20. In @entity1 who were switched over to the other treatment @entity1855 was effective in 9 out of 11 and @entity6310 in 1 @entity1 . Side effects were few. Marked @entity551 occurred in 2 @entity1 , in 1 @entity1 after 5 mg of @entity1855 , and after 5 mg of @entity6310 in the other. It is concluded that @entity1855 is a very effective agent in the treatment of @entity4710 . Selection of @entity1 is emphasized to increase the safety of its use.

title: Comparison of XXXX and @entity6310 in @entity4710 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil', 'Verapamil']

entities_list: @entity6310 :: ('MESH:D011217', 'Chemical') :: ['practolol', 'Practolol']

entities_list: @entity4710 :: ('MESH:D013617', 'Disease') :: ['paroxysmal supraventricular tachycardia']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

answer: @entity1855 :: (MESH:D014700,Chemical) :: ['verapamil']


abstract: 1. The highese disaccharidase activity for @entity969 @entity7969 and @entity8374 was found in the jejunum, followed by the ileum and duodenum. However, the disaccharidase activity for @entity8374 was extremely low compared with that for @entity969 and @entity7969 . 2. For @entity8374 , the Km value was very large and the Vmax value was very low compared compared with the values for @entity969 and @entity7969 . 3. The initial velocity (v) in the presence of the @entity969 and @entity8374 , was equal to the sum of the rates for individual substrates @entity969 ann @entity8374 (v1, v2) respectively (v=v1+v2). Thus, no competition between these substrates was observed. In the case of @entity7969 and @entity8374 , the initial velocity (v) in the presence of both substrates was less than the sum of the individual rates for @entity7969 and @entity8374 (v1, v2) in the absence of the other substrate (v is less than v1 + v2). This finding demonstrates that there is competition between these two substrates for the same enzyme. Furthermore, the apparent Michaelis constant (Km) and the apparent maximal velocity (Vmax) for pure and mixed substrates, i.e., @entity7969 and @entity8374 , at various mole fractions of @entity7969 showed dependence on the mole fraction of @entity7969 . The obtained kinetic data provide strong evidence that both @entity7969 and @entity8374 react at the single active center of maltase.

title: The effects of XXXX on rat intestinal disaccharidases.

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity8374 :: ('MESH:C010745', 'Chemical') :: ['maltitol']

answer: @entity8374 :: (MESH:C010745,Chemical) :: ['maltitol']


abstract: The @entity342 -independent @entity263 cell line @entity5049 is known to exhibit autonomous growth in vitro and in vivo. The purpose of the present study was to investigate the role of @entity310 ( @entity7790 ) and its receptor, the @entity470 , in the regulation of @entity5049 cell proliferation. Results showed that @entity5049 cells secrete factors into conditioned medium that are mitogenic for the @entity263 lines DU145 and LNCaP. Gel filtration chromatography of @entity5049 -conditioned medium revealed a major peak of mitogenic activity at a molecular weight of 5,000 to 10,000 which was inhibited by the addition of antibody to @entity7790 . The synthesis and secretion of @entity7790 by @entity5049 cells were further demonstrated by immunoblotting and radioimmunoassay. Radioreceptor analysis showed a single class (Kd 5.3 nM) of EGF receptors on @entity5049 cells. The presence of Mr 170,000 EGF receptors on @entity5049 cells was further demonstrated by immunoprecipitation of metabolically labeled proteins. @entity7790 was effective in stimulating the growth of low-density, but not high-density, @entity5049 cultures. In addition, the proliferation of @entity5049 cells under serum-free defined conditions was inhibited by antibodies to @entity7790 and/or the @entity470 . These data indicate that @entity7790 / @entity470 interactions are partially responsible for autonomous growth of the @entity5049 cell line and may explain one mechanism of escape from @entity342 -dependent growth in @entity1 @entity263 .

title: Autonomous growth of @entity342 -independent @entity1 @entity263 cells: role of XXXX .

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma', 'less aggressive prostatic carcinoma']

entities_list: @entity310 :: ('7124', 'Gene') :: ['transforming growth factor alpha']

entities_list: @entity470 :: ('1956', 'Gene') :: ['EGF receptor', 'epidermal growth factor (EGF) receptor']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity310 :: (7124,Gene) :: ['transforming growth factor alpha']


abstract: OBJECTIVE: @entity2956 are a group of disorders affecting the temporomandibular joint and/or masticatory muscles. One of the signs associated with @entity2956 is a @entity3137 . During @entity2133 opening, extension occurs at the cervical-cranial junction. The purpose of this investigation was to determine if manual therapy applied to the cervical-cranial junction would significantly improve mouth-opening capacity. METHODS: One hundred one @entity1 were randomly assigned to either an Active Release Technique (ART) group; high-velocity, @entity258 (HVLA) group; or control group. A blinded investigator measured mouth opening using a TheraBite range of motion scale (TheraBite Corporation, West Chester, PA). @entity1 received ART to the suboccipitals or HVLA to the cervical spine at C1 or sat with an investigator for 3 minutes with no treatment. After the treatment session, mouth opening was remeasured. A repeated-measures analysis of variance was used to compare the group mean values. The a priori alpha level was .05. RESULTS: The repeated-measures analysis of variance showed no significant difference between the ART, HVLA, and control groups' pretreatment and posttreatment measurements (F = 0.41, P > .05). CONCLUSION: Manual therapy to the cervical spine did not significantly improve mouth opening in this asymptomatic population. Future trials using @entity1 with @entity3137 are warranted.

title: The effect of cervical spine manual therapy on XXXX opening in asymptomatic subjects.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['Temporomandibular disorders', 'temporomandibular disorders']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['normal mouth']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low-amplitude manipulation']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['reduction in mouth opening', 'restricted mouth-opening measures']

answer: @entity2133 :: (MESH:D014987,Disease) :: ['normal mouth']


abstract: BACKGROUND: There has never been a convincing association between breast implants and @entity0 . A total of 42 cases of @entity1893 of the breast associated with implant capsules have been reported. The majority of the @entity1 have @entity2108 of T-cell origin. These lymphoma types have less frequently been observed in @entity1 without implants. METHODS: The senior author (H.R.W.) diagnosed and treated two @entity1 with @entity2108 in a short period of time. After this, the authors were contacted by other surgeons in Australia who had treated similar cases. RESULTS: The authors report five new cases of @entity2108 associated with breast implants. There is an apparent spectrum of disease, with some cases pursuing an aggressive clinical course, although most have experienced a good prognosis. Both saline and @entity1346 implants are implicated. All implant shells were textured. CONCLUSIONS: Textured surface implants only became widely used in the 1990s and therefore were not significantly represented in the large cohort studies of breast implant safety undertaken in the early 1990s. The diagnosis of @entity2108 in the breast needs to be considered in @entity1 , particularly those presenting with a @entity2080 6 months or more after breast implant insertion. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, V.

title: XXXX and breast implants: five Australian cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast malignancy']

entities_list: @entity2080 :: ('MESH:D049291', 'Disease') :: ['periprosthetic seroma']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity2108 :: ('MESH:D017728', 'Disease') :: ['anaplastic large cell lymphoma']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

answer: @entity2108 :: (MESH:D017728,Disease) :: ['Anaplastic large cell lymphoma']


abstract: A caprine luteal cell line (tsCLC-D) that synthesizes @entity1420 (P4) was established following by transformation with a temperature-sensitive A209 (tsA209) mutant of @entity2235 (SV40). The transformed cells have temperature-sensitive for morphology, cell propagation and @entity1420 steroidogenesis. At the permissive temperature of 34 degrees C, these cells were spindle-shaped and grew with a similar rapidity as @entity5 cells. However, at the nonpermissive temperature of 40 degrees C, the cells have exhibited a round shape and ceased to proliferate because the gene for maintenance of transformation was not expressed. The tsCLC-D cell line responds to @entity5987 , @entity29113 and @entity3333 treatment with an increase in @entity1420 biosynthesis. This cell line still express @entity624 protein, @entity11187 and @entity5986 enzyme of three kinds of steroidogenic protein and enzymes, this characteristic is similar to normal luteal cell. However, the addition of any doses oLH did not increase @entity1420 secretion. We speculate that tsCLC-D might lose the responsiveness to gonadotropins during the immortalization process, while retaining steroidogenic enzyme activity and @entity1420 production. To our knowledge, this is the first report of a stable cell line derived from corpus luteum of ruminant. The tsCLC-D retains steroidogenic capacity, which will make this cell line useful for the studies of regulation of steroidogenesis.

title: Characterization of a stable steroidogenic caprine luteal cell line transformed by a temperature-sensitive XXXX .

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity3333 :: ('MESH:D011284', 'Chemical') :: ['pregnenolone']

entities_list: @entity5987 :: ('MESH:D015124', 'Chemical') :: ['8-Br-cyclic AMP']

entities_list: @entity29113 :: ('MESH:C003585', 'Chemical') :: ['22-hydroxycholesterol']

answer: @entity2235 :: (10633,Species) :: ['simian virus 40']


abstract: PURPOSE: In scattering proton therapy, the beam incidence, i.e. the @entity1 's orientation with respect to the beam axis, can significantly influence stray neutron doses although it is almost not documented in the literature. METHODS: MCNPX calculations were carried out to estimate stray neutron doses to 25 healthy organs of a 10-year-old female phantom treated for an @entity5 . Two beam incidences were considered in this article, namely a superior (SUP) field and a @entity5251 ( @entity5251 ) field. For both fields, a parametric study was performed varying proton beam energy, modulation width, collimator aperture and thickness, compensator thickness and air gap size. RESULTS: Using a standard beam line configuration for a @entity976 treatment, neutron absorbed doses per therapeutic dose of 63 GyGy(-1) and 149 GyGy(-1) were found at the heart for the SUP and the @entity5251 fields, respectively. This dose discrepancy was explained by the different @entity1 's orientations leading to changes in the distance between organs and the final collimator where external neutrons are mainly produced. Moreover, investigations on neutron spectral fluence at the heart showed that the number of neutrons was 2.5times higher for the @entity5251 field compared against the SUP field. Finally, the influence of some irradiation parameters on neutron doses was found to be different according to the beam incidence. CONCLUSION: Beam incidence was thus found to induce large variations in stray neutron doses, proving that this parameter could be optimized to enhance the radiation protection of the @entity1 .

title: Influence of beam incidence and irradiation parameters on stray neutron doses to healthy organs of pediatric @entity1 treated for an XXXX with passive scattering proton therapy.

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['craniopharyngioma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['intracranial tumor']

entities_list: @entity5251 :: ('MESH:D010509', 'Disease') :: ['RLAT', 'right lateral']

answer: @entity5 :: (MESH:D009369,Disease) :: ['intracranial tumor']


abstract: PURPOSE: Numerous studies have suggested that the @entity3646 ( @entity3646 ) @entity17357 polymorphism is associated with @entity356 susceptibility. However, the results were inconsistent. Hence, we carried out a meta-analysis to confirm the conclusion. METHODS: We searched PubMed, Embase, CBM, CNKI, and Wanfang Data to identify relevant studies up to August 20, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the association between @entity3646 @entity17357 polymorphism and @entity356 susceptibility. All the statistical analyses were performed with Stata 12.0 software. RESULTS: A total of eleven published case-control studies were identified, including 2,247 @entity356 @entity1 and 3,370 controls. Overall, no significant association between @entity3646 @entity17357 polymorphism and @entity356 susceptibility was observed in this meta-analysis (T vs C: OR =1.05, 95% CI =0.95-1.17; TT vs CC: OR =1.20, 95% CI =0.89-1.63; CT vs CC: OR =1.14, 95% CI =0.87-1.48; TT + CT vs CC: OR =1.13, 95% CI =0.89-1.44; TT vs CT + CC: OR =1.02, 95% CI =0.88-1.20). Similar results were found in subgroup analyses according to ethnicity and Hardy-Weinberg equilibrium in controls. CONCLUSION: This meta-analysis suggests that @entity3646 @entity17357 polymorphism may not be associated with @entity356 susceptibility. Further studies are needed to validate this conclusion.

title: Genetic association between interluekin-4 XXXX polymorphism and @entity356 susceptibility: evidence based on a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity17357 :: (rs2243250,SNP) :: ['rs2243250']


abstract: @entity35864 (DADS), an important component of garlic (Allium sativum) derivative, has been demonstrated to exert a potential molecular target against @entity1 @entity5 . We investigated @entity22770 -induced expressions of @entity3437 , @entity27300 , @entity522 and @entity23903 (fas-associated protein with death domain) in breast, prostate and @entity2 cells. These showed coincident data when further examined by quantitative reverse transcription-polymerase chain reaction and Western blot analysis. Furthermore, DADS induced a marked amount of @entity589 translocation, @entity4674 release and activation of @entity522 and @entity8187 . DADS-treated @entity5 cells triggered mitochondria-mediated signaling pathways that led to a significant increase in apoptosis induction. Further studies with @entity522 and @entity8187 inhibitors (zDEVD-fmk and zLEHD-fmk, respectively) proved that DADS induces apoptosis through a @entity522 -dependent pathway. DADS is only an agent used in the study. The molecular mechanism presented therefore provides strong additional support to the hypothesis that DADS is a strong inducer of apoptosis through a @entity589 -triggered mitochondria-mediated and @entity522 -dependent pathway. This study shows clearly that DADS causes caspase-dependent apoptosis in @entity1 @entity5 cells through a @entity589 -triggered mitochondrial pathway. Therefore, the mitochondrial pathway might be the target for @entity5 chemoprevention and/or chemotherapy by DADS.

title: XXXX causes caspase-dependent apoptosis in @entity1 @entity5 cells through a @entity589 -triggered mitochondrial pathway.

entities_list: @entity35864 :: ('MESH:C028009', 'Chemical') :: ['Diallyl disulfide']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

answer: @entity35864 :: (MESH:C028009,Chemical) :: ['Diallyl disulfide']


abstract: BACKGROUND: The goal of surgery in the treatment of @entity5 is to resect the maximum @entity5 volume, and to spare the eloquent areas. However, it is difficult to discover the eloquent areas intraoperatively due to individual anatomo-functional variability both for sensori-motor and language functions. Consequently, the surgery of @entity5 frequently results in poor extent of resection or permanent @entity86 , or both, and remains a difficult problem for neurosurgeons. METHODS: From January 2003 to January 2010, 112 @entity1 with @entity10053 in/close to the eloquent areas were operated on under awake anesthesia with the intraoperative direct electrical stimulation for functional mapping of the eloquent areas. The extent of the @entity5 was verified by intraoperative ultrasonography. The maximal resection of the @entity5 and minimal damage of the eloquent areas were the surgical goal of all @entity1 . RESULTS: Totally 356 cortical sites in 99 @entity1 were detected for motor response by intraoperative direct electrical stimulation, 50 sites in 16 @entity1 for sensory, 72 sites in 48 @entity1 for language. Sixty-six @entity1 (58.9%) achieved total resection, 34 (30.4%) subtotal and 12 (10.7%) partial. Fifty-eight @entity1 (51.8%) had no postoperative deficit, while 37 @entity1 (33.0%) had transitory postoperative paralysis, 26 @entity1 (23.2%) with transitory postoperative language disturbance and 3 @entity1 (2.7%) with permanent @entity51 . No @entity1 complained of @entity158 recollection following operation. CONCLUSIONS: Awake anesthesia, intraoperative direct electrical stimulation and ultrasonography are three core techniques for the resection of @entity5 near the eloquent areas. This new concept allows an improvement in the quality of surgery for @entity10053 in/adjacent to eloquent areas.

title: Three core techniques in surgery of XXXX in eloquent areas: awake anaesthesia, intraoperative direct electrical stimulation and ultrasonography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'intrinsic cerebral tumors', 'tumors']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits']

entities_list: @entity10053 :: ('MESH:D018302', 'Disease') :: ['neuroepithelial tumors']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative deficits']

answer: @entity10053 :: (MESH:D018302,Disease) :: ['neuroepithelial tumors']


abstract: Oxyphil cells are characterized by cytoplasm packed with large numbers of mitochondria. Study of these unusual cells may provide information about the regulation of mitochondrial biogenesis. Although it has been suggested that this is a compensatory proliferation due to a @entity2383 , no such dysfunction has been well documented. In this study we considered the possibility of dysfunction in the mitochondrial enzyme F1/Fo- @entity859 triphosphatase(ATPase) as a stimulating factor involved in the mitochondrial proliferation of oxyphil cells. Mitochondria isolated from frozen tissue of a @entity8880 showing structural integrity and purity by electron microscopy were studied. Submitochondrial particles formed by sonic disruption showed the presence of the F1 component of @entity7257 with electron microscopy which was functionally active. The oligomycinsensitive ATPase activity from the @entity8880 was 0.133 mumol/min.mg submitochondrial particle protein which was higher than the readings obtained from normal kidney tissue (0.091 mumol/min.mg SMP protein) obtained from hamsters. Normal @entity1 renal tissue obtained at autopsy contained only nonfunctional mitochondria and therefore could not be used as control tissue. @entity7257 dysfunction does not appear to be the inciting factor in the proliferation of mitochondria seen in oxyphil cell metaplasia and future studies should consider other possibilities. Preliminary functional studies of this nature can be performed with properly prepared frozen surgical tissue.

title: Mitochondrial XXXX triphosphatase in the oxyphil cells of a @entity8880 .

entities_list: @entity8880 :: ('MESH:C537750', 'Disease') :: ['renal oncocytoma']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity7257 :: ('514', 'Gene') :: ['mitochondrial ATPase', 'Mitochondrial ATPase']

entities_list: @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']

answer: @entity859 :: (MESH:D000241,Chemical) :: ['adenosine']


abstract: BACKGROUND: @entity1555 ( @entity1555 ) is a @entity74 that affects skeletal muscles and cardiac muscle tissue. In some cases, @entity296 secondary to @entity519 can lead to @entity296 ( @entity296 ). A @entity74 in the dystrophin gene may increase the susceptibility of myocardium to @entity519 . Available data suggest that this may be caused by impaired secretion of NO, which is bound with secretion of @entity1611 . MATERIAL/METHODS: Male @entity19 C57BI/10ScSn mdx (animal model of @entity1555 ) and healthy @entity19 C57BI/10ScSn were exposed to hypobaric @entity519 in low-pressure chambers. Their hearts were harvested immediately after and 1, 3, 7, and 21 days after exposure to @entity519 . Normobaric @entity19 were used as controls. The expression of @entity1611 in myocardium and cardiac vessel walls was evaluated using immunohistochemistry, Western blotting, and in situ hybridization. RESULTS: @entity1611 expression in myocardium and vessel walls of healthy @entity19 peaked 24 hours after exposure to @entity519 . The expression of @entity1611 in vessel walls was similar in dystrophic and healthy @entity19 ; however, @entity1611 expression in the myocardium of dystrophic @entity19 was impaired, peaking around day 7. In the heart, the total level of @entity1611 depends on @entity1611 expression in myocardium, not in vessel endothelium, and our research demonstrates that the expression of @entity1611 is dystrophin-dependent. CONCLUSIONS: Disordered secretion of @entity1611 in @entity519 myocardium caused the total level of this factor to be impaired in the heart. This factor, which in normal situations protect against @entity519 , promotes the gradual progression of @entity296 .

title: @entity296 in the @entity19 model of XXXX caused by disordered secretion of vascular endothelial growth factor.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['DCM', 'cardiomyopathy', 'myocardial injury', 'dilative cardiomyopathy']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne muscular dystrophy', 'DMD']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia', 'hypoxic']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic defect', 'genetic neuromuscular disorder']

answer: @entity1555 :: (MESH:D020388,Disease) :: ['Duchenne muscular dystrophy']


abstract: Sixty @entity1 with @entity0 (mean age: 61 years; range 36-78 years) were treated with @entity1259 ( @entity1259 ), 60 mg m-2, as single drug therapy. The drug was administered as 2 hours' constant rate infusions. The pharmacokinetics of the drug during the first course of treatment was evaluated by measurements of the plasma concentration of @entity1259 at the end of the infusion period. There was a five-fold inter-individual variation of the dose-normalized maximum plasma concentration, which increased with increasing age of the @entity1 . There was no correlation between this pharmacokinetic parameter and degree of @entity28 . An increase in maximum plasma concentration was associated with an increasing degree of @entity1665 (p = 0.025). Also the degree of @entity390 and @entity391 showed a tendency to increase with increasing maximum plasma concentration (p = 0.07). Fifty four of the sixty @entity1 entered in the present study were evaluable for clinical response. There was one CR (complete remission). Seventeen @entity1 achieved PR (partial response), and twenty five @entity1 had @entity66 ( @entity66 ). Eleven @entity1 did not respond to treatment. The median maximum plasma concentrations were 322, 316, 336 and 288 ng ml-1 in @entity1 with CR, PR, @entity66 and @entity1726 , respectively. The results in the present study showed that 60 mg m-2 of @entity1259 given as a constant rate infusion over 2 hours is a useful alternative to more @entity146 combination drug therapy for the treatment of @entity0 .

title: @entity1259 as a single agent therapy for the treatment of XXXX --a pharmacokinetic and clinical study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['stable disease', 'SD']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ["4'epi-Doxorubicin", 'Epirubicin']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: PURPOSE: @entity10771 is effective as a single agent in low-grade @entity1893 ( @entity1893 ). Combined with other antineoplastic agents it enhances the antitumor effect. Our aim was to define the therapeutic efficacy and @entity137 of a combination of @entity3118 , @entity786 and @entity619 (FluCyD) in @entity1 with advanced @entity1893 . @entity1 AND METHODS: Twenty-five adults with pretreated advanced-stage low-grade @entity1893 were treated with three-day courses of @entity3118 25 mg/m2/day, @entity786 350 mg/m2/day, and @entity619 20 mg/day, every four weeks for a maximum of six courses. RESULTS: Of the 25 @entity1 , 18 (72%) responded, 8 (32%) achieving CR and 10 (40%) PR. Seven were failures. The median follow-up was 21 months (5-26). Eight CR @entity1 remain in CR after 5-21 months. Of 10 PR @entity1 , 3 are in continuous PR without further treatment after 12, 17 and 18 months. Myelosuppression was the most prevalent @entity137 effect. Although severe @entity3028 (granulocyte count nadir < 500/microliter) and @entity882 (platelet count nadir < 50,000/microliter) occurred in only 10% and 16% of courses, respectively, slow granulocyte or platelet count recovery caused delay of 40% of the courses. Nine @entity1 (36%) required discontinuation of therapy because of persistent @entity3028 and/or @entity882 : three after one course, three after 2-4 courses, and three after five courses. Thirteen infectious episodes in 11 @entity1 complicated 11% of courses. Two of 10 @entity1 monitored for the circulating EBV load showed increased viral load. One of these developed @entity146 . @entity404 + lymphocytes declined from a pre-therapy median value of 425/microliter to 141/microliter post-treatment (P = 0.001). @entity1503 were rare and mild. CONCLUSIONS: The combination of @entity3118 with @entity786 and @entity619 is effective in pretreated advanced-stage low-grade @entity1893 . It may broaden the range of therapeutic options in the salvage treatment of these @entity1 . The main @entity137 of this combination is prolonged myelosuppression that may cause treatment delay or withdrawal. The benefit of adding granulocyte colony-stimulating factor, particularly in @entity1 with poor marrow reserve, needs to be investigated.

title: @entity3118 , @entity786 , and XXXX (FluCyD) combination is effective in pretreated low-grade @entity1893 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxic']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive lymphoma']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Non-hematologic toxicities']

entities_list: @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL', 'low-grade lymphoma']

entities_list: @entity10771 :: ('MESH:C042382', 'Chemical') :: ['Fludarabine phosphate']

entities_list: @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia']

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: @entity687 , a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for @entity5 -associated angiogenesis in @entity5 . The polymorphism @entity687 @entity27730 ( @entity27731 ) is known to be associated with the expression of @entity687 protein and is related to @entity5 . A serum anti- @entity876 antibody, a new @entity5 marker, increases in accordance with the mutation of @entity5 suppressor gene @entity876 . Previous studies have reported the association between @entity687 and @entity876 mutation in @entity5 cells or tissues. Therefore, we hypothesized that @entity687 polymorphism might be associated with serum anti- @entity876 antibody levels. Study subjects were 197 @entity1 (103 males and 94 females, aged 15 to 56 years) who were enrolled in a case-control study on peptic ulcer disease from January to March 2007 in the Uzbekistan Republic. Serum anti- @entity876 antibody, @entity787 , and CA19-9 levels were measured, and @entity687 @entity27730 was genotyped. The A allele frequency in control subjects was 0.48, which is close to the previous reports for Caucasian populations. The proportion of subjects with positive anti- @entity876 antibodies (higher than 1.3 U/ mL) was greater for AA genotype carriers compared to T allele carriers (17% for AA, and 6% for TA+TT; OR 3.4, p = 0.025 after adjusting for age, sex, comorbidity and ethnicity). Such a difference was not observed for either @entity787 or CA19-9. We demonstrated that the @entity687 -251 AA genotype was associated with higher anti- @entity876 antibodies than those of the reference range. Further studies are warranted to clarify whether those with this genotype carrier are susceptible to @entity5 .

title: @entity687 @entity27730 polymorphism was associated with positive anti- XXXX antibodies in Uzbekistan population.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'several cancers', 'cancer', 'malignant diseases']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: OBJECTIVES: Strategies for the optimal surgical management of @entity1498 with associated @entity4615 continue to be debated upon. We describe a previously unreported surgical technique for the management of this combination of defects and present our early results. METHODS: Thirty-one @entity1 (median age: 73 days and median weight: 3.9 kg) underwent repair of @entity1498 with associated @entity299 , in a single-stage, through a midline sternotomy. Twenty-eight @entity1 had associated @entity6127 and 1 had a type I interruption. The @entity1498 and when necessary, the distal arch, was repaired prior to the institution of cardiopulmonary bypass. Cardiopulmonary bypass was subsequently instituted for the repair of the associated @entity4615 . RESULTS: All @entity1 had successful repair of @entity1498 and @entity6127 without the need for rescue cardiopulmonary bypass. In addition, 29 @entity1 had closure of one or more @entity1757 , 3 @entity1 had an arterial switch procedure and 1 had repair of double outlet right ventricle. Repair of supramitral ring and subaortic membrane was performed in another 3 @entity1 . One @entity1 underwent concomitant mitral valve repair. There was one in-hospital mortality (3.22%) due to fulminant @entity295 . The median follow-up was 29.5 months (range: 1-58 months). There was no late mortality. Two @entity1 required @entity384 for recurrent @entity1498 . Overall event-free survival rate was 88.5% at both 2 and 3 years of follow-up after surgery. However, intervention-free survival at 2 and 3 years of follow-up was 91.7% among the survivors. CONCLUSION: Repair of @entity1498 and @entity6127 or type I arch interruption is feasible prior to the institution of cardiopulmonary bypass without the use of hypothermic @entity1167 or regional cerebral perfusion, with acceptable and reproducible results.

title: Off-pump midline repair of XXXX when associated with @entity4615 : an alternate approach for single-stage correction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['balloon dilatation']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defects']

entities_list: @entity4615 :: ('MESH:C538262', 'Disease') :: ['intracardiac defects']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of aorta', 'coarctation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac defects']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest']

entities_list: @entity6127 :: ('MESH:D007569', 'Disease') :: ['distal arch hypoplasia']

answer: @entity1498 :: (MESH:D001017,Disease) :: ['coarctation of aorta']


abstract: BACKGROUND: Major @entity130 induces a dysregulation of immune response supported in parts by lymphocyte dysfunction. Controversial data about a shift within the T-helper cell subsets @entity1198 /Th2 are reported. METHODS: To prove whether @entity1198 /Th2-type cytokine plasma levels reflect the postulated Th2 shift after @entity130 , we investigated in a retrospective study 195 severely injured @entity1 (47 @entity1 , 148 @entity1 ; mean age 39.7 +/- 15.8 years; Injury Severity Score 32.0 +/- 11.3 points; overall 1,887 samples) during their ICU stay posttrauma. Mortality rate was 19%. @entity1198 -type cytokines @entity1199 ( @entity1199 ), @entity379 , IL-12 ( @entity12329 ), and @entity8923 and Th2-type cytokines IL-4, @entity688 , and @entity4382 were determined using the enzyme-linked immunosorbant assay technique in @entity1 and in healthy controls. RESULTS: @entity1199 and @entity379 were seldom detectable. All other mediators were significantly increased matched to controls (p < 0.05). All cytokines were elevated most prominent during weeks 1 and 2 posttrauma and declined thereafter. A trend toward lower levels in nonsurvivors was seen for both groups of cytokines. However, significant differences were only seen for Injury Severity Score, age, white blood cells, and @entity1851 . All mediators correlated positively with each other (p < 0.01), a Th2-type shift was not observed. Two groups of @entity1 were identified: one group with generally high plasma levels of all cytokines investigated and a second group of nonresponders who presented with low or diminished plasma levels in which most nonsurvivors were found. CONCLUSION: We conclude that in plasma no @entity1198 /Th2 shift can be observed after major @entity130 .

title: XXXX - and Th2-type cytokines in plasma after major @entity130 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity379 :: ('3458', 'Gene') :: ['interferon gamma']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1198 :: (51497,Gene) :: ['Th1']


abstract: BACKGROUND: The postoperative analgesic potential of periarticular anesthetic infiltration (PAI) after TKA is unclear as are the complications of continuous femoral @entity616 on @entity121 function. QUESTIONS/PURPOSES: We asked (1) whether PAI provides equal or improved @entity282 control in comparison to a femoral @entity616 in @entity1 who have undergone TKA; and (2) if so, whether PAI improves early postoperative @entity121 control and facilitates rehabilitation. METHODS: We randomized 60 @entity1 to receive either PAI or femoral @entity616 . During the first 5 days after TKA, we compared narcotic consumption, @entity158 control, @entity121 function, walking distance, knee ROM, capacity to perform a straight leg raise, and active knee extension. Medication-related side effects, complications, operating room time, and hospitalization duration were compared. RESULTS: Opioid consumption was lower in the PAI group during the first 8 postoperative hours (12.5 mg versus 18.7 mg @entity1286 ), as was reported @entity158 at rest (1.7 versus 3.5 on a 10-point VAS). Thereafter, narcotic consumption and reported @entity158 were similar up to 120 hours. More subjects in the femoral @entity616 group experienced @entity121 motor block (37% versus 0% in the PAI group). On Days 1 to 3, subjects in the PAI group experienced better capacity to perform the straight leg raise, active knee extension, and had longer walking distances. CONCLUSIONS: PAI provided @entity158 control equivalent to that of a femoral @entity616 while avoiding a motor block and its negative functional impacts. The data suggest it should be considered an alternative to a femoral @entity616 . LEVEL OF EVIDENCE: Level I, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.

title: Periarticular injection in knee arthroplasty improves XXXX function.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['quadriceps']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['nerve block']

answer: @entity121 :: (MESH:D009135,Disease) :: ['quadriceps']


abstract: @entity8 -reperfusion injury (IRI) is an important contributor to delayed graft function (DGF) and poor outcome of allografts. Small clinical studies suggest a beneficial role for human anti-thymocyte globulin (ATG) in DGF. We investigated the short-term effect of mouse anti-thymocyte globulin (mATG) on kidney warm IRI in @entity19 . We administered either mATG, @entity95 immunoglobulin (RIgG), or saline with different dosing schedules in three different IRI models: 30 min bilateral, 60 min bilateral, and 45min unilateral IRI. mATG effectively depleted circulating T cells but had less effect on kidney-infiltrating T cells. There was no difference in serum @entity1011 levels between groups in each study. Scoring of @entity8 and regenerating tubules revealed no difference between groups. The percentage of @entity5168 (+) @entity1961 (-)CD8(-) double-negative (DN) T cells, which were reported to contribute to the pathogenesis of @entity1988 , increased and the percentages of regulatory T cells and NK cells decreased in the post- @entity63 kidneys of mATG treated @entity19 . mATG did not alter the expression of pro-inflammatory cytokines such as @entity60 or anti-inflammatory cytokines such as @entity1618 in post- @entity63 kidneys. mATG treatment, whether initiated before @entity63 or immediately after reperfusion, had minimal effects on @entity8 following warm IRI in @entity19 .

title: The effect of murine anti-thymocyte globulin on experimental kidney warm XXXX -reperfusion injury in @entity19 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal injury', 'renal tubular damage', 'Kidney ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic', 'ischemia']

entities_list: @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemia']


abstract: This study investigated the functional performance of two major subtypes of @entity303 , @entity195 ( @entity195 ) and @entity1294 ( @entity1294 ), by the @entity177 ( @entity177 ), and to understand the need for assistance in performing activities of daily living. The subjects comprised 64 @entity195 and 21 @entity1294 @entity1 who were recruited from two epidemiologic studies of @entity303 with a total of 3,931 community residents aged 65 years and above in southern Taiwan. The results showed that the severity of @entity303 was similar between the two groups. The mean score for @entity195 was 82.7 and for @entity1294 was 56.5 for total @entity177 (p < 0.05), 61.6 and 41.7 for the motor dimension (p < 0.05), and 21.1 and 15.7 for the cognitive dimension (p < 0.05). There were significant differences (p < 0.01) between @entity195 and @entity1294 in six @entity177 items and borderline or marginal significance (p < 0.05) in most of the @entity177 items. For @entity195 @entity1 , stairs, lower dressing, bathing, and tub/shower transfer were the most difficult items in the motor dimension, and it was memory in the cognitive dimension. For @entity1294 @entity1 , bathing, upper and lower dressing, and grooming were the most difficult items in the motor dimension, and it was problem solving in the cognitive dimension. @entity1294 @entity1 were more dependent on all @entity177 items and required more assistance than @entity195 @entity1 . The functional performances of @entity303 @entity1 were significantly associated with @entity303 severity and subtypes, together accounting for 40% of the variability in total @entity177 . In conclusion, most @entity303 @entity1 are dependent in daily activities and different types and severity of @entity303 lead to different disability profiles; individualized care is, therefore, most appropriate.

title: Functional performance of @entity195 and XXXX in southern Taiwan.

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia', 'VaD']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['FIM', 'Functional Independence Measure']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity1294 :: (MESH:D015140,Disease) :: ['vascular dementia']


abstract: OBJECTIVE: To present pathologic and radiographic features of 3 @entity1 with @entity1636 -2 with uncertain malignant potential and 1 @entity652 with areas of @entity4648 . METHODS: We describe 3 @entity1 who had @entity1636 with foci of @entity4648 . For each @entity1 , the clinical and pathologic data are reviewed. RESULTS: @entity5953 @entity1 were @entity1 , with a mean age at presentation of 58 years. The lesion size averaged 6.8 cm (range, 3.9 to 11.0), and the mean gland weight was 128.8 g (range, 32.5 to 249). Two @entity1 showed imaging findings compatible with @entity9272 . Pathologically, 2 of the lesions were classified as @entity1636 of uncertain malignant potential, and 1 lesion was classified as an @entity822 . @entity5953 lesions contained myelolipomatous foci throughout the @entity5 , and 2 of the @entity5 contained several pure @entity16204 . CONCLUSION: @entity1636 , including those associated with an uncertain malignant potential, may be associated with areas of @entity4648 . Imaging studies may result in a false diagnosis of a benign @entity9272 and potential undertreatment in such @entity1 .

title: @entity1636 with XXXX : report of 3 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity16204 :: ('MESH:C537029', 'Disease') :: ['lipomatous foci']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'neoplasm']

entities_list: @entity4648 :: ('MESH:D008679', 'Disease') :: ['myelolipomatous and lipomatous metaplasia']

entities_list: @entity1636 :: ('MESH:D018268', 'Disease') :: ['Adrenocortical neoplasms', 'adrenocortical neoplasms']

entities_list: @entity822 :: ('MESH:D018246', 'Disease') :: ['adrenocortical adenoma']

entities_list: @entity9272 :: ('MESH:D018209', 'Disease') :: ['adrenal myelolipoma']

answer: @entity4648 :: (MESH:D008679,Disease) :: ['myelolipomatous and lipomatous metaplasia']


abstract: @entity391 represents a rare clinical manifestation during @entity410 originating from the temporal lobes of the nondominant hemisphere. The precise anatomic structures responsible for @entity391 remain to be clarified. Ictal single photon emission computed tomography (SPECT), which allows one to visualize the three-dimensional dynamic changes of regional cerebral blood flow ( @entity13279 ) associated with the ongoing @entity302 activity, should be useful to study the brain areas activated during @entity391 . METHODS: We performed ictal Tc-HMPAO SPECT scans in two @entity1 with @entity1315 ( @entity1315 ) whose @entity410 were characterized by @entity391 . @entity1315 was documented by typical clinical @entity410 semiology, interictal and ictal EEG findings, hippocampal @entity194 on magnetic resonance imaging (MRI) scan, and a @entity410 -free outcome after selective amydalohippocampectomy. In both @entity1 , @entity410 originated in the nondominant temporal lobe. We obtained accurate anatomic reference of @entity13279 changes visible on SPECT by a special coregistration technique of MRI and SPECT. We used ictal SPECT studies in 10 @entity1 with @entity1315 who had @entity410 without @entity391 as controls. RESULTS: In the two @entity1 with @entity391 , we found a significant hyperperfusion of the nondominant temporal lobe (inferior, medial, and lateral superior) and of the occipital region on ictal SPECT. In @entity1 without @entity391 , on the contrary, these brain regions never were hyperperfused simultaneously. CONCLUSIONS: Ictal SPECT provides further evidence that activation of a complex cortical network, including the medial and lateral superior aspects of the temporal lobe, and maybe the occipital lobes, is responsible for the @entity391 .

title: Regional cerebral blood flow during XXXX : an ictal SPECT study in two @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['ictal retching and vomiting', 'generation of ictal vomiting', 'ictal vomiting', 'PURPOSE: Ictal vomiting']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'mesial temporal lobe epilepsy']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic']

answer: @entity410 :: (MESH:D012640,Disease) :: ['temporal lobe seizures associated with ictal vomiting']


abstract: BACKGROUND: Oral food challenge test doses are recommended to be performed at least 20  min apart; however, the times of symptom provocation from the start of the oral food challenge have never been compared between different foods. In this study, the durations from the start of the oral food challenge to symptom development in @entity1 with egg or milk @entity566 were compared. METHODS: Thirty-eight and 74 @entity1 who had previously passed oral food challenges to 96  g of yogurt and pumpkin cake containing    whole egg underwent oral food challenges with 200  mL raw @entity291 's milk and 1 whole scrambled egg, respectively; of these, 15/38 and 33/74 @entity1 had a reaction. RESULTS: The median ages of @entity1 with a positive challenge were 5.8 and 5.1  years for milk and eggs, respectively. The median times for the first symptom occurrence were 20  min (range, 5-55  min) and 50  min (5-480  min), respectively (p   =   0.009). The first symptoms developed within 30, 60, and 90  min in 12/15 (80  %), 15/15 (100  %), and 15/15 (100  %) @entity1 with @entity6132 , and in 10/33 (30.3  %), 20/33 (60.6  %), and 26/33 (78.8  %) @entity1 with egg @entity566 , respectively. The median times of peak symptoms were 50  min (10-210  min) and 120  min (30-560  min) (p   =   0.001), and those of symptom disappearance were 90  min (30-240  min) and 180  min (80-700  min) for milk and eggs (p   =   0.002), respectively. DISCUSSION: Based on the results of our study, symptoms developed within 30 min for only a subset of @entity1 for eggs, and may even take upwards of 60 min to develop. The times of symptom disappearance were 90 min and 180 min for milk and eggs, respectively, indicating that egg- @entity56 @entity1 should be observed for a longer period time than milk- @entity56 @entity1 . CONCLUSIONS: @entity56 induced by milk appeared and disappeared sooner than those induced by eggs.

title: XXXX to milk appear sooner than reactions to hen's eggs: a retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity6132 :: ('MESH:D016269', 'Disease') :: ['milk allergies']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['Allergic reactions', 'allergic']

answer: @entity56 :: (MESH:D004342,Disease) :: ['Allergic reactions']


abstract: AIM: @entity63 ( @entity63 ) has to be considered an "alarm bell" of a more or less severe organic or systemic @entity455 . Positive findings at neuroimaging means tissue damage. The purpose of this retrospective study was to assess the role of neuroimaging in the management of @entity1 presenting with @entity63 , and to consider the relative implications. METHODS: In a consecutive series of 82 @entity1 (53 males, 29 females, mean age: 65.9  13.1 years) admitted for @entity63 , it was possible to review the history and the clinical data of 66 @entity1 , including @entity13203 score, laboratory including plasmatic D-dimer, and neuroimaging data including computed tomography (CT) and magnetic resonance imaging including diffusion-weighted with apparent diffusion coefficient measure (DWI-ADC) obtained at diagnosis and by a week later (16 by CT, and 50 by DWI-ADC). Thirty-three @entity1 underwent DWI-ADC within 24 hours from symptoms onset. Statistical analysis has been performed by non-parametric tests (  2 and Mann-Whitney), and logistic regression by a commercially available software. RESULTS: CT and/or DWI-ADC showed signs of @entity2806 in 23/66 (35%) @entity1 . 12 out of the 35 @entity1 with a 24-hour DWI-ADC follow-up were positive. Statistical analysis showed that positive neuroimaging was significantly associated only with familial history of @entity65 (P<0.012) and previous @entity63 / @entity64 (P<0.046). CONCLUSION: In this @entity1 series, at least 35% of @entity1 with @entity63 had a positive neuroimaging, especially DWI-ADC. Positive neuroimaging seems an independent factor. @entity1 with @entity63 need an early assessment by neuroimaging including DWI-ADC, in order to obtain a correct classification and prognosis.

title: [Neuroimaging and definition of transient XXXX attack].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vasculopathy']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['acute ischemic lesions']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Transient ischemic attack', 'TIA']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemic']


abstract: BACKGROUND: @entity788 (NETs) are increasingly discovered incidentally during radiologic or endoscopic examinations. The frequency of incidental detection is unknown. It is also unclear whether @entity1 with incidentally discovered, early-stage, asymptomatic @entity5 should be treated similarly to @entity1 who present with @entity5 -related symptoms. METHODS: @entity1 with nonmetastatic pancreatic NETs treated at the H. Lee Moffitt Cancer Center between 1999 and 2010 were assigned a stage (I-III) on the basis of the new American Joint Committee on Cancer classification. The frequency of incidentally diagnosed @entity5 was evaluated and stratified by stage. Progression-free survival was measured by log rank testing to compare @entity1 with incidentally detected versus symptomatic @entity5 . Multivariate analysis was performed controlling for other prognostic factors including @entity5 stage, grade, and location, and @entity1 age. RESULTS: Among 143 @entity1 with nonmetastatic pancreatic NETs, 56 @entity1 (40%) had @entity5 that were discovered incidentally. Most stage I @entity5 (55%) were incidental. The 5-year progression-free survival rate was 86% for incidentally diagnosed @entity5 , versus 59% for symptomatic @entity5 (P = 0.007). On multivariate analysis, incidental detection of @entity5 was the strongest prognostic factor for progression. CONCLUSIONS: A sizable fraction of @entity1 with early-stage pancreatic NETs are diagnosed incidentally during evaluations for other conditions or unrelated symptoms. This study highlights the necessity of developing guidelines for management of @entity1 with incidentally discovered @entity5 .

title: XXXX : an analysis of incidence and outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic neuroendocrine tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'early-stage tumors', 'tumors']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Incidental detection of pancreatic neuroendocrine tumors']


abstract: PURPOSE: To explore the patterns of cortical thickness and cortical surface @entity854 in @entity1 with @entity2704 (with the expectation of seeing reduced cortical thickness and surface area in regions subserving nociception and increased cortical thickness and surface area in regions involved in @entity2704 pathogenesis) and to assess their correlation with clinical and radiologic manifestations of the disease. MATERIALS AND METHODS: Approval of the local ethical committee was obtained, as well as written informed consent from each @entity1 . T2-weighted and three-dimensional T1-weighted magnetic resonance images of the brain were acquired in 63 migraineurs and 18 matched healthy control subjects. Cortical thickness and cortical surface area were estimated. By using a general linear model approach, a vertex-by-vertex statistical analysis (P < .01) was used to assess between-group comparisons (migraineurs vs control subjects, the aura effect, the effect of @entity62 [ @entity62 ]) and the correlations between cortical thickness and surface area measurements and @entity1 ' clinical and radiologic characteristics. RESULTS: Compared with control subjects, @entity1 with @entity2704 showed reduced cortical thickness and surface area in regions subserving @entity158 processing (P < .01). These two metrics were increased in regions involved in executive functions and visual motion processing (P < .01). The anatomic overlap of cortical thickness and cortical surface @entity854 was only minimal, with cortical surface @entity854 being more pronounced and more widely distributed than @entity2526 . Cortical thickness and surface @entity854 were related to aura and @entity62 (P < .01) but not to disease duration and attack frequency. CONCLUSION: @entity2526 occur in migraineurs and may represent the results of a balance between an intrinsic predisposition, as suggested by cortical surface @entity854 , and disease-related processes, as indicated by @entity2526 .

title: XXXX in @entity1 with @entity2704 : a surface-based analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participant', 'patients']

entities_list: @entity2526 :: ('MESH:D025063', 'Disease') :: ['cortical thickness abnormalities', 'Cortical abnormalities']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['area abnormalities']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['WMHs', 'white matter hyperintensities']

answer: @entity2526 :: (MESH:D025063,Disease) :: ['Cortical abnormalities']


abstract: UNASSIGNED: To explore the epigenetic mechanisms underlying the effects of anti- @entity1534 @entity1534 ( @entity1534 ) alone and combined with @entity2247 inhibitor ( @entity12698 ), we dynamically evaluated the associations between @entity2247 methylation alterations and @entity1819 evolution during the process of interventions. In a total of 809 trial @entity1 @entity2247 methylation levels were quantitatively detected before and after treatment. The self-comparison at the same stomach site for each subject showed significant methylation alteration differences among intervention groups (P < 0.001). With placebo group as reference, @entity2247 methylation levels were decreased in anti-H. @entity1534 [OR, 3.30; 95% confidence interval (CI), 2.16-5.02], @entity12698 (OR, 2.04; 95% CI, 1.36-3.07), and anti-H. @entity1534 followed by @entity12698 (OR, 2.10; 95% CI, 1.38-3.17) groups. When stratified by baseline histology, the three active arms significantly decreased @entity2247 methylation levels in indefinite @entity1141 / @entity1141 subjects, and ORs were 3.65 (95% CI, 1.96-6.80) for anti-H. @entity1534 , 2.43 (95% CI 1.34-4.39) for @entity12698 , and 2.80 (95% CI, 1.52-5.15) for anti-H. @entity1534 followed by @entity12698 , respectively. No additive effect on @entity2247 methylation was found for anti-H. @entity1534 followed by @entity12698 than two treatments alone. Compared with subjects without methylation reduction, higher opportunity for @entity1819 regression was found in subjects with decreased @entity2247 methylation levels, especially for indefinite @entity1141 / @entity1141 subjects (OR, 1.92; 95% CI, 1.03-3.60). These findings suggest that anti-H. @entity1534 or @entity12698 treatment alone could decrease @entity2247 methylation levels in @entity356 . @entity2247 methylation alteration was associated with the regression of indefinite @entity1141 / @entity1141 , which might serve as a potential biomarker for chemoprevention efficacy. Cancer Prev Res; 9(6); 1-7.   2016 AACR.

title: Alterations of Cyclooxygenase-2 Methylation Levels Before and After Intervention Trial to Prevent XXXX in a Chinese Population.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity12698 :: ('MESH:C105934', 'Chemical') :: ['celecoxib']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric lesion']

entities_list: @entity1534 :: ('210', 'Species') :: ['pylori', 'H. pylori', 'Helicobacter']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric mucosa']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']


abstract: Consecutive @entity1 undergoing total hip replacement in 43 centres were randomly assigned to receive blindly either enoxaparin (40 mg) or @entity23294 (4,500 anti-Factor IU Xa), as once daily subcutaneous injections. The first injection was administered 12 h preoperatively. Efficacy was assessed by bilateral venography performed 12-14 days postoperatively. Efficacy and safety were blindly and centrally adjudicated. Among the 499 @entity1 included, 440 had a venogram. The total incidence of DVTs was 44 (20.1%) of the 219 @entity1 of the enoxaparin group and 48 (21.7%) of the 221 @entity1 of the @entity23294 group. The upper limit of the 80% confidence interval of the difference between the two treatment groups was less than 5.0%. Therefore according to the protocol's specifications equivalence was shown. Proximal DVTs occurred in 10.5% of the enoxaparin group (23 @entity1 ) and in 9.5% (21 @entity1 ) of the @entity23294 group. No overt major @entity548 was observed. One @entity1 in the @entity2120 group developed severe @entity882 and died. The LMWH @entity23294 appears clinically to be as effective and safe as enoxaparin in the prophylaxis of @entity1150 after total hip replacement, at the doses used and under the conditions of this study.

title: Prevention of XXXX after hip replacement--comparison between two low-molecular heparins, @entity23294 and enoxaparin.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity23294 :: ('MESH:C081247', 'Chemical') :: ['tinzaparin']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity2120 :: ('MESH:D017984', 'Chemical') :: ['enoxaparin']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']


abstract: OBJECTIVE: To evaluate the pattern of Ki-67, @entity588 and COX-2 expression in the glandular epithelium and stroma of malignant and benign @entity1478 in postmenopause. STUDY DESIGN: A total of 390 postmenopausal @entity1 underwent surgical hysteroscopy; @entity1 with @entity1478 were included. Polypoid lesions were histologically classified as benign, premalignant or malignant lesions. Ki-67, @entity588 and COX-2 expression were evaluated by immunohistochemistry according to percentage of stained cells, staining intensity, and final score. RESULTS: The prevalence of @entity5 in @entity1478 was 7.1% and was associated with @entity548 . The final score showed that only mean COX-2 expression was higher in @entity1127 (6.1 +/- 2.5) (p < 0.001) and stroma (2.4 +/- 3.0) (p < 0.01). There was a higher @entity588 expression, especially in the glandular epithelium, with no differences between @entity1127 and premalignant/malignant @entity1127 . Ki-67 expression was low in both @entity1127 and premalignant/malignant @entity1127 . CONCLUSION: Polyps in postmenopause have a high COX-2 expression that is higher in malignant @entity1127 than in @entity1127 . There was no difference in Ki-67 and @entity588 expression between malignant @entity1127 and premalignant/malignant @entity1127 .

title: Is the immunohistochemical expression of proliferation (Ki-67) and apoptosis ( XXXX ) markers and cyclooxigenase-2 (COX-2) related to carcinogenesis in @entity1478 ?

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['postmenopausal bleeding']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['malignant polyps both in the glandular epithelium', 'benign polyps', 'polyps']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial polyps']

answer: @entity588 :: (596,Gene) :: ['Bcl-2']


abstract: PURPOSE: To assess the efficacy and safety of @entity1341 compared with @entity3303 in local anesthesia of nasopharynx through meta-analysis. METHODS: A number of medical literature data bases were searched electronically. Relevant journals and references of included studies were manually searched. Two reviewers independently performed data extraction and quality assessment. RESULTS: Four studies were included. Visual analog scale (VAS) scores, acceptable discomfort, and @entity548 scores were analyzed for @entity1341 versus @entity3303 . When considering the VAS scores, @entity1341 as a local anesthetic agent was better than @entity3303 in controlling the @entity158 of postoperative @entity1 (p < 0.00001). From VAS scores of @entity1 for transnasal fiberoptic nasopharyngolaryngoscopic examination that was performed to evaluate upper airway structures, @entity3303 was found to be better at @entity158 management in @entity1 who underwent transnasal endoscopic examination (p < 0.00001). However, when analyzing the acceptable discomfort of @entity1 who underwent upper @entity344 , which serves as a valuable tool to evaluate upper @entity344 , the @entity1 in the @entity1341 group demonstrated a higher acceptable discomfort than the @entity1 in the @entity3303 group (p = 0.008). With regard to the @entity548 scores of the @entity1 with nasal surgery, @entity3303 was better at @entity548 in postoperative @entity1 compared with @entity1341 (p = 0.0007). These results indicated that @entity1341 showed @entity158 control of postoperative @entity1 and acceptable discomfort in @entity1 with upper @entity344 . @entity3303 had a significantly increased ability the @entity158 of @entity1 with transnasal fiberoptic nasopharyngolaryngoscopic examination and @entity548 in postoperative @entity1 . No systemic adverse events were reported. CONCLUSION: @entity1341 was found to have better promotion to @entity158 control than did @entity3303 for the @entity1 after nasal surgery. @entity3303 had a significantly increased inhibition of @entity548 in these postoperative @entity1 ; however, the efficacy between @entity1341 and @entity3303 was unclear for the @entity1 who had transnasal endoscopic examinations.

title: Efficacy and safety of XXXX versus @entity3303 in local anaesthesia of the nasopharynx: A meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal endoscopy', 'gastrointestinal structures']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine', 'Bupivacaine']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['Lidocaine', 'lidocaine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['better pain', 'pain']

answer: @entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']


abstract: @entity4346 ( @entity4346 ) is frequently associated with @entity101 and constitutes a major @entity65 factor, the reduction of which should be considered when initiating antihypertensive therapy. To assess the effects of @entity7486 on @entity4346 , 18 @entity101 @entity1 were included in the study (11 @entity1 and 7 @entity1 , age 53.6 +/- 2.9 years, mean +/- standard deviation) whose supine diastolic blood pressure was greater than 95 mm Hg without (n = 11) or with (n = 7:6 beta blockers, 1 @entity460 antagonist) antihypertensive therapy. All presented with @entity4346 , echocardiographically defined by a left ventricular mass index greater than 110 g/m2. After a 2-week preinclusion period, all @entity1 received @entity7486 , 2.5 mg/day, for a period of 6 months. Physical examination including blood pressure measurement was performed on selection (M-1/2), before (M0), and after 1 (M1), 3 (M3) and 6 (M6) months of @entity7486 treatment, and echocardiography was performed at M0 and M6. Quality of life was evaluated by means of questionnaires completed by the @entity1 and the physician, and a visual analog scale was completed by the @entity1 at M-1/2, M0 and M6. All clinical parameters remained stable during the 2-week preinclusion period. @entity7486 administration induced a highly significant @entity551 from 173.9 +/- 2.9/100.5 +/- 1.2 mm Hg at M0 to 150.9 +/- 1.9/90.5 +/- 1.3 mm Hg at M1 (p less than 0.001), and 145.0 +/- 1.7/86.0 +/- 1.5 mm Hg at M6 (p less than 0.001). Similar favorable effects were observed in the upright position.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effects of @entity7486 on left ventricular mass and function in systemic @entity101 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity7486 :: ('MESH:D007190', 'Chemical') :: ['indapamide', 'Indapamide']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['Left ventricular hypertrophy', 'LVH']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['reduction in both supine systolic and diastolic blood pressures']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular risk']

answer: @entity4346 :: (MESH:D017379,Disease) :: ['left ventricular hypertrophy']


abstract: @entity29 ( @entity29 ) are associated with an increased risk for @entity1031 , which is often manifested as @entity1150 or @entity1151 , at extra-intestinal sites. Although some of the cytokines that contribute to @entity8787 pathogenesis are also known to alter the coagulation pathway, it remains unclear whether these mediators also contribute to the extra-intestinal @entity715 often associated with @entity8787 . The objective of this study is to evaluate the role of @entity635 in enhanced extra-intestinal @entity715 observed in @entity19 with dextran @entity2397 (DSS)-induced @entity1960 . @entity635 concentrations were measured in plasma, colon, and skeletal muscle of @entity164 ( @entity164 ) control and colitic @entity19 . Microvascular @entity715 was induced in cremaster muscle microvessels by using a light/ @entity130 model. The effects of exogenous @entity635 on @entity715 formation were determined in control @entity164 @entity19 . DSS-induced thrombogenesis was evaluated in @entity164 @entity19 treated with an @entity635 antibody and in IL-1 receptor-deficient (IL-1r(-/-)) @entity19 . DSS-induced @entity32 in @entity164 @entity19 was associated with enhanced @entity715 formation in arterioles. @entity635 concentrations were elevated in inflamed @entity121 . Exogenous @entity635 enhanced @entity715 in control @entity19 in a dose-dependent manner. DSS colitic @entity19 treated with the @entity635 antibody as well as IL-1r(-/-) @entity19 exhibited significantly blunted thrombogenic responses. These findings implicate @entity635 as a mediator of enhanced microvascular @entity715 that occur in extra-intestinal tissues during @entity32 .

title: @entity635 mediates the extra-intestinal XXXX associated with experimental @entity1960 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['colonic inflammation']

entities_list: @entity2397 :: ('MESH:C012036', 'Chemical') :: ['sodium sulfate']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['IBDs', 'Inflammatory bowel diseases']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombosis', 'thrombus']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['colon and skeletal muscle']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['dye injury']

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombosis']


abstract: OBJECTIVE: To explore the isometric attachment site of knee lateral collateral ligament (LCL) in the femoral lateral condyle; to introduce the isometric reconstruction of knee lateral collateral ligament with the long head of @entity427 tendon. METHODS: Among 16 @entity1 with @entity3331 treated with isometric reconstruction of the lateral collateral ligament, 10 @entity1 were male and 6 @entity1 were female, with an average age of 38.4 years (ranged from 20 to 58 years). Twelve @entity1 were chronic injuries, four @entity1 were @entity131 , with an average duration of 5 days to 11 months. Eleven @entity1 had @entity130 ,3 @entity1 had @entity130 combined with @entity130 , 2 @entity1 had @entity130 combined with @entity130 . The middle one third of the long head of @entity427 tendon was cut to be fixed to the isometic bony tunnel of the femoral lateral condyle. The lateral stability of the knee was evaluated mainly through varus stress test. RESULTS: The better isometric attachment site is from the anatomical caput fibulae attachment site or the middle one third of the long head of @entity427 to the femoral lateral condyle to 8-10 mm in front of the anatomical femoral attachment site of the lateral collateral ligament. The average follow-up period was 13.5 months (ranged from 12 to 24 months). At the 12th month after operation, there was no varus instability in full extension. At 30 degrees flexion, one-grade varus instability was found in 2 @entity1 . In varus stress test the lateral joint space increased less than 5 mm compared to the healthy side. CONCLUSION: The method provided good stability for the knee and acquired satisfactory clinical results.

title: [Isometric reconstruction of knee lateral collateral ligament with the long head of XXXX tendon].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['acute injuries']

entities_list: @entity3331 :: ('MESH:D007718', 'Disease') :: ['knee injury']

entities_list: @entity427 :: ('MESH:D012021', 'Disease') :: ['biceps femoris']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['ACL injury', 'LCL injury', 'PCL injury', 'simple LCL injury']

answer: @entity427 :: (MESH:D012021,Disease) :: ['biceps femoris']


abstract: OBJECTIVES: Our aim was to review our pathological archive to find out the actual incidence of micropapillary pattern (MPP) in our @entity189 @entity1 population and determine its correlation with clinical outcome. @entity1 AND METHODS: 14 out of 170 cases with complete clinical follow-up were clinicopathologically analyzed. The extent of @entity9016 was determined as @entity5 percentage. RESULTS: 12 further cases with MPP were defined in the review. The percentage of @entity1 with positive MPP increased in parallel to the @entity5 stage. There was no considerable difference between MPP-positive and MPP-negative groups according to the progression rates in non-muscle-invasive and muscle-invasive groups. Progression-free survival was much shorter in MPP cases, but again without statistical significance. Also, there was no significant relation between percentage of MPP and progression-free survival. CONCLUSIONS: Awareness of pathologists about MPP and its highly possible relation with @entity146 must be raised, as it may be more common than reported. A multicentric review of a large number of cases with MPP is needed for a better definition of its biological behavior. Focal MPP cases may have a better prognosis but this needs to be confirmed.

title: Micropapillary pattern in XXXX : a clinicopathological analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma']

answer: @entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']


abstract: OBJECTIVES: To describe the characteristics of @entity1 consulting commune primary healthcare posts for acute undifferentiated @entity221 not being @entity311 (AUF), and to explore the diagnostic and therapeutic responses of the healthcare workers. METHODS: All @entity1 presenting with AUF at 12 commune health posts and one clinic at the provincial @entity311 station, Binh Thuan, a dengue endemic province in southern Vietnam, were included. Record forms were used to fill in @entity1 and diseases characteristics, pre-referral treatment, signs and symptoms, provisional diagnosis and installed treatment, referral and final outcome. RESULTS: Two thousand ninety-six @entity1 were included from April 2001 to March 2002. The median delay to attend the health posts was, 0.87 day for > 5, 1.15 days for @entity1 aged 5-15 years and 1.41 days for adults (P < 0.001). Sixty-five per cent of @entity1 took some measures before consulting the health post, of whom 82% applied self-medication and 69% took antibiotics. Pre-referral medication with antibiotics increased with age ( @entity4736 .012 per year of age; 95% CI: 1.004-1.019). The diagnostic and therapeutic response of healthcare workers was very unspecific. The tourniquet test was inappropriately used as general discriminating test, not only for detecting dengue haemorrhagic @entity221 . Empiric antibiotic therapy was installed in 77.2% of cases. CONCLUSIONS: Management of uncomplicated @entity221 , not being @entity311 , at the primary healthcare level in Vietnam is non-specific, dominated by searching signs of @entity548 and empiric antibiotic treatment. This can probably be improved by better education.

title: Acute undifferentiated XXXX in Binh Thuan province, Vietnam: imprecise clinical diagnosis and irrational pharmaco-therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic dengue']

answer: @entity221 :: (MESH:D005334,Disease) :: ['fever']


abstract: BACKGROUND: @entity1592 ( @entity1592 ) affects 5-10% of all newborns and is associated with a high risk of abnormal neurodevelopment. The timing and patterns of brain reorganization underlying @entity1592 are poorly documented. We developed a @entity95 model of @entity1592 allowing neonatal neurobehavioral assessment and high resolution brain diffusion magnetic resonance imaging (MRI). The aim of the study was to describe the pattern and functional correlates of fetal brain reorganization induced by @entity1592 . METHODOLOGY/PRINCIPAL FINDINGS: @entity1592 was induced in 10 New Zealand fetal @entity95 by ligation of 40-50% of uteroplacental vessels in one horn at 25 days of gestation. Ten contralateral horn fetuses were used as controls. Cesarean section was performed at 30 days (term 31 days). At postnatal day +1, neonates were assessed by validated neurobehavioral tests including evaluation of tone, spontaneous locomotion, reflex motor activity, motor responses to olfactory stimuli, and coordination of suck and swallow. Subsequently, brains were collected and fixed and MRI was performed using a high resolution acquisition scheme. Global and regional (manual delineation and voxel based analysis) diffusion tensor imaging parameters were analyzed. @entity1592 was associated with significantly poorer neurobehavioral performance in most domains. Voxel based analysis revealed fractional anisotropy (FA) differences in multiple brain regions of gray and white matter, including frontal, insular, occipital and temporal cortex, hippocampus, putamen, thalamus, claustrum, medial septal nucleus, anterior commissure, internal capsule, fimbria of hippocampus, medial lemniscus and olfactory tract. Regional FA changes were correlated with poorer outcome in neurobehavioral tests. CONCLUSIONS: @entity1592 is associated with a complex pattern of brain reorganization already at birth, which may open opportunities for early intervention. Diffusion MRI can offer suitable imaging biomarkers to characterize and monitor brain reorganization due to @entity2241 .

title: Neonatal neurobehavior and diffusion MRI changes in brain reorganization due to intrauterine growth restriction in a XXXX model.

entities_list: @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'Intrauterine growth restriction']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal diseases']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: AIMS: Impaired myocardial sarcoplasmic reticulum @entity460 ATPase 2a (SERCA2a) activity is a hallmark of failing hearts, and SERCA2a gene therapy improves cardiac function in animals and @entity1 with @entity712 ( @entity712 ). Deregulation of microRNAs has been demonstrated in @entity712 pathophysiology. We studied the effects of therapeutic AAV9.SERCA2a gene therapy on cardiac miRNome expression and focused on regulation, expression, and function of @entity9630 in reverse remodelled failing hearts. METHODS AND RESULTS: We studied a chronic post- @entity583 @entity712 model treated with AAV9.SERCA2a gene therapy. @entity712 resulted in a strong deregulation of the cardiac miRNome. @entity9630 expression was decreased in failing hearts, but normalized in reverse remodelled hearts after AAV9.SERCA2a gene delivery. Increased @entity584 activation in cultured cardiomyocytes led to phosphorylation of @entity16389 and subsequent exclusion from the nucleus, resulting in @entity9630 gene silencing. In vitro SERCA2a expression also rescued @entity9630 in failing cardiomyocytes, whereas SERCA2a inhibition reduced @entity9630 levels. In vivo, @entity584 and @entity16389 were highly phosphorylated in failing hearts, but reversed to normal by AAV9.SERCA2a, leading to cardiac @entity9630 restoration. Likewise, enhanced @entity1372 - @entity460 exchanger 1 ( @entity27778 ) expression during @entity712 was normalized by SERCA2a gene therapy. Validation experiments identified @entity27778 as a novel functional @entity9630 target. CONCLUSION: SERCA2a gene therapy of failing hearts restores @entity9630 expression by an @entity584 / @entity16389 -dependent pathway, which is associated with normalized @entity27778 expression and improved cardiac function.

title: SERCA2a gene therapy restores microRNA-1 expression in XXXX via an @entity584 / @entity16389 -dependent pathway.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'Heart failure', 'heart failure']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']