abstract: OBJECTIVES: This study aimed to investigate how use of a fiber sleeve may reduce interfacial debonding and improve fracture strength of @entity15296 with flared root canals. METHODS: Pulpless premolars with flared root canals were restored either with a fiber-reinforced post (FRP) alone or with an FRP wrapped in a hollow tubular fiber sleeve. A normal root restored with an FRP alone served as a control. The integrity of resin-dentin and resin-fiber interfaces in the restored roots was evaluated by a stereoscopic system after penetrating a dye. Four roots were tested for each experimental group. @entity174 resistance in pulpless premolars with flared root canals restored with an FRP alone or with an FRP/sleeve combination were investigated under bonded and non-bonded conditions with static fracture testing (n=8), and stress distribution in these restored premolars were tested by @entity1417 ( @entity1417 ). RESULTS: Flared root canals restored with an FRP/sleeve combination demonstrated superior integrity at the cervical resin-dentin interface to root canals with an FRP alone. Premolars with a flared root canal restored with an FRP/sleeve combination showed significantly greater fracture resistance compared with premolars restored with an FRP alone. @entity1417 showed that once interfacial de-bonding extended to the cervical region of the root, stress concentration in the root dentin dramatically increased. SIGNIFICANCE: The FRP/sleeve combination was effective in reducing debonding and, hence, improving the fracture strength of pulpless premolars with flared root canals.

title: The use of a fiber sleeve to improve fracture strength of XXXX with flared root canals.

entities_list: @entity15296 :: ('MESH:D019553', 'Disease') :: ['pulpless teeth']

entities_list: @entity1417 :: ('MESH:C565217', 'Disease') :: ['finite element analysis', 'FEA']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['Fracture']

answer: @entity15296 :: (MESH:D019553,Disease) :: ['pulpless teeth']


abstract: UNASSIGNED: We hypothesized that @entity5438 ( @entity13525 ) overexpression can regulate @entity46 cell proliferation, apoptosis and @entity7 ( @entity7 ) expression in the endometrium. The overexpression of @entity5438 ( @entity13525 ) was obtained by transduction of @entity5438 ( @entity13525 ) in primary cultures of endometrium obtained from @entity1 with @entity46 tissue with gene therapy technology. First generation bicistronic adenovirus: AdCMVhp27IRESEGFP (Adp27) and AdCMVNull (AdNull) were engineered in order to induce @entity5438 ( @entity13525 ) expression in endometrial cells primary culture. The effect of @entity5438 ( @entity13525 ) overexpression was elucidated through the cell proliferation evaluation and the expression of the cell cycle-related proteins @entity986 , @entity3544 , @entity5438 , and @entity876 . Cell cycle and apoptosis in endometrial cells from @entity1 with and without @entity46 were also evaluated. The @entity7 levels were evaluated 1 and 7  days after transduction. The experiments were performed using Immunofluorescence stainings and flow cytometry technique. The cell proliferation statistically diminished markedly following @entity5438 ( @entity13525 ) overexpression in the @entity46 group. This process was accompanied, however, by a statistically significant modulation of the cell cycle-related proteins @entity986 , @entity3544 , @entity5438 and @entity876 markedly increase following @entity5438 ( @entity13525 ) overexpression in the @entity46 group (p  <  0.001) and an increase in apoptotic cells was observed. In the @entity46 group, significant downregulation of @entity7 expression was observed 7  days after @entity5438 ( @entity13525 ) overexpression, attaining levels strikingly similar to those observed in the control endometrial cells. The findings of this study showed a link between the cell cycle control protein ( @entity13525 ) and angiogenesis ( @entity7 ). Our results, also reinforces the background of endometrial dysfunction as part of the origin of @entity46 . We believe that better knowledge of endometrium milieu and the establishment of the link between different, previously describe, altered pathways in this tissue can facilitate future genetic cell therapy.

title: @entity13525 ) overexpression regulates XXXX expression, cell proliferation and apoptosis in cell culture from eutopic endometrium of @entity1 with @entity46 .

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

answer: @entity7 :: (7422,Gene) :: ['VEGF']


abstract: @entity6701 nanoparticles ( @entity3759 NP) are one of the most abundantly utilized nanoparticles in the world. Studies have demonstrated the ability of the anatase crystal of @entity3759 NP to produce reactive @entity26 species (ROS) in the presence of ultraviolet radiation (UVR), a co-exposure likely to occur in aquatic ecosystems. The goal of this study was to examine the photo-induced @entity137 of anatase @entity3759 NP under natural sunlight to Daphnia magna. D. magna were exposed to a range of UVR intensities and anatase @entity3759 concentrations in an outdoor exposure system using the sun as the source of UVR. Different UVR intensities were achieved using UVR opaque and transparent plastics. Anatase @entity3759 -NP demonstrated the reciprocal relationship seen in other @entity6337 compounds such as @entity2555 ( @entity2556 ) at higher UVR treatments. The calculated 8h LC50 of anatase @entity3759 NP was 139ppb under full intensity ambient natural sunlight, 778ppb under 50% natural sunlight, and >500ppm under 10% natural sunlight. Mortality was also compared between animals allowed to accumulate a body burden of anatase @entity3759 for 1h and organisms whose first exposure to anatase @entity3759 aqueous suspensions occurred under UVR. A significantly greater @entity137 effect was observed in aqueous, low body burden suspensions than that of @entity3759 1h body burdens, which is dissimilar from the model presented in @entity2556 . Anatase @entity3759 presents a unique photo-induced @entity137 model that is different than that of established @entity6337 compounds.

title: Photo-induced XXXX of @entity6701 nanoparticles to Daphnia magna under natural sunlight.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxic']

entities_list: @entity6337 :: ('MESH:D017484', 'Disease') :: ['phototoxic']

entities_list: @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity6701 :: ('MESH:C009495', 'Chemical') :: ['Titanium dioxide']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: BACKGROUND: Electroconvulsive therapy (ECT), an effective treatment for @entity308 , also improves motor symptomatology in @entity191 ( @entity191 ). We have previously demonstrated that ECT stimulates @entity935 (DA) function in the striatum of healthy non- @entity1 primates, suggesting that DA may contribute to antidepressant effects. OBJECTIVE: We investigated the potential role of DA mechanisms in the amelioration of @entity191 following a clinical course of ECT. METHODS: We treated non- @entity1 primates rendered mildly bilaterally or unilaterally parkinsonian with @entity5212 ( @entity5212 ), with a course of 6 ECT treatments. Using positron emission tomography, animals were scanned at baseline and at various time points after ECT with tracers of the DA system. Data were analyzed using the Logan reference tissue model and statistics were performed using orthogonal polynomial contrasts. RESULTS: There was no change in binding of the @entity7712 tracer in the lesioned striata after ECT as opposed to what we measured in the striatum of healthy animals. @entity11641 binding to the D(2/3) receptors was unaffected in all groups. However, there were increases in vesicular @entity1154 transporter type 2 and D(1) receptor binding in the @entity5212 -lesioned striata after ECT, returning towards baseline by 6 weeks. CONCLUSION: We suggest that the effects of ECT in @entity191 may proceed from a mechanism similar to that in healthy animals but with a blunted dopaminergic response, likely due to the significant loss of striatal DA terminals. The safety of ECT, its mild side effects and its stimulatory effects of the DA system may thus make it an attractive adjunct to antiparkinsonian treatment.

title: Antiparkinsonian mechanism of electroconvulsive therapy in XXXX -lesioned non- @entity1 primates.

entities_list: @entity5212 :: ('MESH:D015632', 'Chemical') :: ['MPTP', '1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD symptoms', 'PD']

entities_list: @entity1154 :: ('CHEBI:25375', 'Chemical') :: ['monoamine']

entities_list: @entity11641 :: ('MESH:D020891', 'Chemical') :: ['Raclopride']

answer: @entity5212 :: (MESH:D015632,Chemical) :: ['MPTP']


abstract: BACKGROUND: @entity296 frequently complicates @entity1582 ( @entity2783 ), yet only a small number of these @entity1 develop large @entity1143 refractory to diuretic therapy and thoracentesis. We hypothesized that disruption of pleural function by @entity527 underlies persistent @entity1143 (PPEs) in @entity1 with @entity2783 . METHODS: We performed a retrospective study of @entity2783 @entity1 with and without PPEs who had been referred to Boston University between 1994 and 2001. The presence of PPEs was defined by a failure to resolve the condition with thoracentesis and aggressive diuresis. @entity296 @entity1 without @entity1143 constituted the control (cardiac) group. Indexes of @entity1581 , @entity1985 , thyroid function, and echocardiographic measures of left and right ventricle performance were compared between groups. When available, closed needle biopsies and autopsy specimens of parietal pleura were examined for @entity527 . RESULTS: Among 636 @entity1 with @entity2783 , 35 PPE @entity1 underwent a median of three thoracenteses each. No statistical differences were found between the PPE and cardiac groups in echocardiographic measures of septal thickness, @entity1002 , or diastolic compliance. Right ventricular (RV) hypokinesis occurred more often in PPE @entity1 ; however, nearly half of this group had normal RV systolic function. Renal function, plasma protein levels, and thyroid function were the same between groups. @entity1985 range @entity644 (ie, > 3 g/d) was more prevalent in the cardiac group than in the PPE group (44% vs 26%, respectively; p = 0.057). All pleural biopsies in the PPE group (six biopsies) revealed @entity527 . Autopsy samples of parietal pleura were negative for disease in two cardiac @entity1 . Eighteen @entity1 had chest tubes placed, and 11 underwent pleurodesis. PPE signaled limited survival among @entity1 who were ineligible for treatment. Untreated PPE @entity1 lived a median 1.8 months vs 6 months for untreated cardiac @entity1 (p = 0.031). Survival after intensive chemotherapy and autologous stem cell transplantation was comparable in the PPE and cardiac groups (21.8 vs 15.6 months, respectively; p = 0.405). CONCLUSION: In @entity2783 @entity1 with @entity299 , neither echocardiographic measures of ventricular function nor the degree of @entity3450 distinguished those @entity1 with PPEs. We conclude that @entity456 plays a central role in the creation and persistence of @entity1143 among @entity1 with @entity2783 .

title: Persistent XXXX in @entity1582 : etiology and prognosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['Restrictive cardiomyopathy', 'AL cardiomyopathy']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits']

entities_list: @entity1581 :: ('MESH:D010265', 'Disease') :: ['plasma cell dyscrasia']

entities_list: @entity3450 :: ('MESH:D009401', 'Disease') :: ['nephrosis']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['primary systemic amyloidosis']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac amyloid']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['Nephrotic', 'nephrotic syndrome']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular systolic function']

entities_list: @entity456 :: ('MESH:D010995', 'Disease') :: ['pleural amyloid infiltration']

answer: @entity1143 :: (MESH:D010996,Disease) :: ['pleural effusions']


abstract: Individualization of radiation doses is presumed to result in better radiotherapy outcome. Success rate in measuring radiosensitivity is probably the most limiting factor for present radiosensitivity assays to be introduced into clinical routine. To find a simpler predictive parameter, we compared the radiosensitivity of dermal fibroblasts and head and @entity213 (SCC) cell lines established from the same individuals. The radiosensitivity was tested using the clonogenic 96-well plate assay. The surviving fraction at 2.0 Gy ( @entity19593 ) was determined, as well as the mean inactivation dose (AUC) of @entity5 cells. @entity19593 of SCC cell lines and skin fibroblasts were 0.25-0.44 and 0.11-0.43, respectively. AUC of SCC cells was 1.4-2.1 Gy. Dermal fibroblasts were more radiosensitive than SCC cells in 14 of 15 cases. In 1 @entity1 (UT-SCC-8), @entity5 cells were found to be more radiosensitive than corresponding dermal fibroblasts. There was a clear tendency to a correlation between radiosensitivities of these 2 cell types, but statistical significance was reached only when the data of UT-SCC-8 was excluded. In our material, the intrinsic radiosensitivity of head and neck SCC cells could in most cases be predicted from the intrinsic radiosensitivity of dermal fibroblasts established from the same individual.

title: Does skin fibroblast radiosensitivity predict XXXX cell radiosensitivity of the same individual?

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['neck squamous cell carcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['squamous cancer']


abstract: When @entity548 disorders coincide with pregnancy, they might be congenital or acquired diseases, if not arising as a more acute complication of the pregnancy itself. The paper gives a review of the most common @entity548 disorders out of internal medical constellations. History taking is the most effective way to open the diagnostic approach. If childbearing is desired the couple in question should be counselled accordingly in collaboration with a hematologist. Some conditions might be unfavourable, e.g. hemophila in male offspring, others might be serious but manageable, as in v. @entity2880 or @entity882 . Prenatal invasive diagnostics with fetal blood sampling at an early stage of pregnancy may reduce the hazards for the baby insofar, as it allows the more precise estimation of fetal risks at birth. Cesarean section will not in all cases be the way of choice (e.g. in v. @entity2880 ), in others it might be the better way to deliver a fetus at risk in order to avoid @entity932 (in severe cases of @entity3039 ). Always both, mother and fetus, are at risk, but almost in any cases in different shades and grades of severeness. There is rarely a firm correlation of the maternal and the fetal hemostatic parameters in cases of connatal or acquired @entity6243 . Pregnancy itself leads to a certain compensation of defects in clotting factors, since the synthesis of factors increase or they are circulating more in activated form. Pregnancy is a state of a silently ongoing @entity5642 at least in the uteroplacental circulation. From there it is linked with the general circulation of the maternal organism. When immunologic etiologies in @entity882 play a role, there will always be the incalculable rate of placental transfer of antiplatelet-antibodies to the fetus. The entire field requires knowledge, counseling, collaboration and foresight.

title: [ XXXX in pregnancy].

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage']

entities_list: @entity6243 :: ('MESH:D006474', 'Disease') :: ['hemorrhagic disorders']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['autoimmunologic thrombocytopenic purpura', 'thrombocytopenias']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation']

entities_list: @entity2880 :: ('MESH:D014842', 'Disease') :: ['Willebrand-Disease']

answer: @entity6243 :: (MESH:D006474,Disease) :: ['Hemorrhagic disorders']


abstract: BACKGROUND: This study investigated the efficacy and @entity137 of weekly single-agent @entity2600 in @entity1 with @entity3 relapsing after @entity900 -based chemotherapy. @entity1 AND METHODS: Fourteen @entity1 were enrolled. A total number of 29 cycles (one cycle consisted of @entity2600 100 mg/m2 on days 1, 8, 15, qd 28) were applied. @entity2600 was continued until disease progression or unacceptable @entity137 occurred. Where @entity137 was less than WHO grade 3, the dose of @entity2600 was escalated in 20 mg steps in subsequent cycles up to a maximum dose of 140 mg/m2. @entity1 were assessed for response according to WHO criteria every second cycle. RESULTS: Of the 13 evaluable @entity1 , 2 achieved a partial response (PR) and 3 disease stabilisation (NC); @entity74 ( @entity74 ) was noted in 8 @entity1 . Median time to progression was 2 months (range: 1-8 months) and median survival from start of study treatment was 5 months (range: 2-16 months). Grade 3 @entity137 consisted of @entity294 (n=3), @entity221 (n=1) and @entity158 (n=1). CONCLUSION: Single-agent @entity2600 has moderate activity in @entity900 -refractory @entity418 .

title: A phase II trial of weekly @entity2600 in XXXX -refractory @entity418 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['Irinotecan', 'irinotecan', 'CPT-11']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['PD', 'progressive disease']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: INTRODUCTION: @entity6583 ( @entity6583 ) is the most common @entity4801 with wide distribution which is caused by larval forms of @entity8785 . Our aim was to: show the most common clinical manifestations of @entity1 with @entity6583 and their importance in diagnosing this disease; examine the value of serologic diagnostic methods in blood and cerebrospinal fluid; to emphasize the value of radiological diagnostic methods--CT and MRI of the brain, in relation to the applied protocol of therapy, as well as the impact of anti-parasitic therapy on the outcome of this disease. MATERIAL, METHODS AND RESULTS: 13 @entity1 with @entity6583 (from 35 to 63 years of age, median age 49; 61.5% male and 38.5% female) were treated at the Clinic of Infectious Diseases in Novi Sad during a five-year period. Two @entity1 had a positive epidemic data of @entity11333 in childhood. The most common clinical manifestation was @entity10 in 61.5% of @entity1 , and generalized @entity410 and @entity1269 in 46.2%. @entity32 was present in 27.3% of @entity1 . Two of five @entity1 had positive ELISA test for @entity3993 in the serum and cerebrospinal fluid. CT and MRI findings confirmed parenchimal form of @entity6583 in 30.8% of @entity1 , while calcifications were found in 69.2% of @entity1 . All @entity1 were treated with @entity3753 , 800 mg a day, in two doses, 30.76% of @entity1 had a favorable outcome of the disease, 53.7% of @entity1 were discharged with complications, and one @entity1 died. CONCLUSION: The most common manifestation of @entity6583 in our @entity1 was @entity10 , followed by general @entity410 and @entity1269 . Radiological diagnostic methods--CT and MRI--proved to be most valuable both in diagnostics and follow-up of lesions. All our @entity1 were treated with @entity3753 ; @entity619 was applied in @entity1 with severe inflammatory reaction, and anti- @entity410 drugs in @entity1 with @entity410 .

title: [ XXXX --5 years' experience at the Clinic for Infectious Diseases].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity11333 :: ('MESH:D007411', 'Disease') :: ['parasitic diseases of the intestinal tract']

entities_list: @entity6583 :: ('MESH:D020019', 'Disease') :: ['NCC', 'Neurocysticercosis']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive', 'convulsions']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Meningeal inflammation']

entities_list: @entity3993 :: ('MESH:D003551', 'Disease') :: ['cysticercosis']

entities_list: @entity3753 :: ('MESH:D015766', 'Chemical') :: ['Albendazole']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone']

entities_list: @entity8785 :: ('6204', 'Species') :: ['Taenia Solium']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic disease']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity6583 :: (MESH:D020019,Disease) :: ['Neurocysticercosis']


abstract: PURPOSE: The use of technology to implement cost-effective health care management on a large scale may be an alternative for @entity6 management but needs to be evaluated in controlled trials. This study assessed the utility and cost-effectiveness of an automated @entity6 Monitoring and Management System (DRMS) in glycemic control versus usual care. METHODS: In this randomized, controlled study, @entity1 with uncontrolled @entity6 on insulin were randomized to use of the DRMS or usual care. @entity1 in both groups were followed up for 6 months and had 3 clinic visits at 0, 3, and 6 months. The DRMS used text messages or phone calls to remind @entity1 to test their blood @entity413 and to report results via an automated system, with no @entity1 interaction unless a @entity1 had severely high or low blood @entity413 . The DRMS made adjustments to insulin dose(s) based on validated algorithms. @entity1 reported medication adherence through the Morisky Medication Adherence Scale-8, and @entity6 -specific quality of life through the @entity6 Daily Quality of Life questionnaire. A cost-effectiveness analysis was conducted based on the estimated overall costs of DRMS and usual care. FINDINGS: A total of 98 @entity1 were enrolled (59 [60%] female; mean age, 59 years); 87 @entity1 (89%) completed follow-up. @entity4051 c was similar between the DRMS and control groups at 3 months (7.60% vs 8.10%) and at 6 months (8.10% vs 7.90%). Changes from baseline to 6 months were not statistically significant for self-reported medication adherence and @entity6 -specific quality of life, with the exception of the Daily Quality of Life-Social/Vocational Concerns subscale score (P = 0.04). IMPLICATIONS: An automated system like the DRMS may improve glycemic control to the same degree as usual clinic care and may significantly improve the social/vocational aspects of quality of life. Cost-effectiveness analysis found DRMS to be cost-effective when compared to usual care and suggests DRMS has a good scale of economy for program scale up. Further research is needed to determine how to sustain the benefits seen with the automated system over longer periods.

title: Evaluation of a Remote Monitoring System for XXXX Control.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'human', 'patients', 'patient', 'Participants']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes Remote', 'diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: BACKGROUND AND PURPOSE: PHACE is an acronym for posterior fossa @entity75 , @entity2695 , @entity432 , @entity1498 and @entity299 , and @entity735 . Several case reports of @entity385 ( @entity385 ) in individuals with PHACE have been published, but risk factors for @entity385 in PHACE have not been clearly defined. The objective of this article is to review all cases of @entity64 in PHACE in @entity1 and describe clinical characteristics that may be associated with an increased risk of @entity385 . METHODS: A literature and registry search was conducted to identify @entity1 with PHACE who had experienced @entity385 . Data were analyzed to determine age of onset, presenting signs and symptoms, and clinical features among this cohort compared with PHACE without @entity385 . RESULTS: Twenty-two individuals with PHACE and @entity385 were identified. Imaging of the arteries of the head and neck was reported in 20 of 22. Narrowing or nonvisualization of at least 1 great cerebral vessel was present in 19 of 20 and of those, 15 had >=  2 vessels involved. @entity6127 were reported in 13 of 22 individuals. CONCLUSIONS: @entity3894 , @entity509 , or occlusion of a major cerebral artery appears to be a significant risk factor for @entity385 in @entity1 with PHACE, especially when >1 vessel is involved or if there is @entity1498 .

title: @entity64 in @entity1 with posterior fossa @entity75 , @entity2695 , @entity432 , @entity1498 and XXXX , and @entity735 : a systematic review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangiomas']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain malformations']

entities_list: @entity509 :: ('MESH:C538429', 'Disease') :: ['hypoplasia']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['eye abnormalities']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of the aorta']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac defects']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial anomalies']

entities_list: @entity6127 :: ('MESH:D007569', 'Disease') :: ['Aortic arch anomalies']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['arterial ischemic stroke', 'AIS']

answer: @entity299 :: (MESH:D006331,Disease) :: ['cardiac defects']


abstract: UNASSIGNED: 8543 Background: Few studies have assessed late effects in @entity521 ( @entity521 ) survivors. METHODS: 63 high risk @entity521 @entity1 were seen at the Long Term Follow-Up Clinic since 1991. RESULTS: Median age at diagnosis was 3.0 years. 11 @entity1 had stage 3 disease and 52 stage 4 (2 stage 2B initially). Median follow-up was 7.06 years. All @entity1 had surgery and received chemotherapy, 56 (89%) radiation therapy, 38 (60%) immunotherapy and 35 (56%) autologous stem cell transplant. 60 @entity1 (95%) had late effects and 18 (29%) had more than three. The most frequent complications were: @entity393 (62%), @entity1375 (24%), @entity2670 (41% of females), musculoskeletal (21%), pulmonary (19%), neurocognitive (14%), visual (14%), dental (13%) and secondary @entity5 (6%). Grades of severity were: 1 (24%), 2 (44%), 3 (28%) and 4 (4%) (CTCAE v 3.0). Survivors who received @entity900 were more at risk to develop @entity393 compared to those who did not receive it ( OR, 9.74; 95% CI: 0.9-101.6). A total @entity786 dose greater than 7.4 g was associated with @entity2670 (p=0.02). @entity358 was correlated with chest irradiation (p=0.009). @entity227 were both associated with cranial radiation (p=0.001 and p=0.002 respectively). In a subset of 28 @entity1 who were prepubertal at their first visit, there was a significant correlation between the change in height @entity214 (-0.28) and the follow-up time (p=0.04). CONCLUSIONS: Despite very intensive multimodality treatment, survivors of high-risk @entity521 face relatively moderate late effects. Their early identification and treatment are important for the quality of life of the survivors. No significant financial relationships to disclose.

title: Long term complications from treatment in survivors of high risk XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['primary hypothyroidism']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['Visual and dental problems']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatinum']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['Pulmonary dysfunction']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['NB', 'neuroblastoma']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian failure']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

answer: @entity521 :: (MESH:D009447,Disease) :: ['neuroblastoma']


abstract: BACKGROUND: Hemodialysis vascular access dysfunction currently is a huge clinical problem. Although @entity2548 ( @entity2548 ) are the preferred form of permanent dialysis access, they continue to have significant problems with @entity177 . Although inadequate dilatation of the venous segment was believed to have a role in @entity177 , the exact pathogenesis of @entity177 is unknown despite the magnitude of the clinical problem. STUDY DESIGN: Case series. SETTING _ @entity1 : Hemodialysis @entity1 . OUTCOMES _ MEASUREMENTS: Stenotic venous segments from 4 @entity1 with @entity177 were subjected to a detailed histological, morphometric, and immunohistochemical analysis. RESULTS: All 4 @entity1 had significant luminal @entity850 , primarily as a result of @entity1373 . This was confirmed through morphometric analysis, which documented intima-media area and thickness ratios that were greater than unity. Cellular phenotyping studies showed that the majority of cells within the region of @entity1373 were myofibroblasts, with smaller numbers of contractile smooth muscle cells. LIMITATIONS: We described only a limited number of specimens. CONCLUSIONS: We show for the first time that aggressive @entity1373 is present in venous segment specimens from @entity1 with @entity177 . Future therapies to address this problem will need to target this pathogenetic pathway.

title: XXXX in early @entity2548 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['eccentric neointimal hyperplasia', 'neointimal hyperplasia']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['early AVF failure']

entities_list: @entity2548 :: ('MESH:D001164', 'Disease') :: ['AVFs', 'arteriovenous fistulas']

answer: @entity1373 :: (MESH:D006965,Disease) :: ['Neointimal hyperplasia']


abstract: OBJECTIVES: To investigate gender-attributable differences regarding clinical outcome [disease activity, physical function and quality of life (QoL)] and radiographic damage in @entity1 with @entity5427 over time. METHODS: Data from the Outcome in @entity5427 International Study were used. Disease activity was assessed by the BASDAI, ASDAS and CRP; physical function by BASFI; QoL by the Short Form-36, @entity1691 Quality of Life (ASQoL) score and European Quality Of Life scale; and radiographic damage by the modified Stoke @entity5427 Spine Score (mSASSS). Cross-sectional comparative analyses were done at baseline. Next, separate models were created to assess gender-attributable differences on each outcome measure over time using time-adjusted generalized estimating equations. RESULTS: A total of 216 @entity1 [154 (72.3%) males, mean age 43.6 years (s.d. 12.7), symptom duration 20.5 years (s.d. 11.8), mean follow-up duration 8.3 years (s.d. 4.1)] were included. At baseline, male compared with female @entity1 had lower self-reported disease activity (BASDAI 3.2 vs 3.9, P = 0.03) but more radiographic damage (mSASSS 13.8 vs 6.5, P = 0.02). No significant gender-attributable differences in other clinical parameters were found. In multivariable analysis, male gender was significantly associated with a better ASQoL (B = -1.18, 95% CI: -2.17, -0.20, P = 0.02), and in a separate model with a higher mSASSS over time (B = 8.24, 95% CI: 4.38, 12.09, P < 0.01). CONCLUSION: In this prospective cohort study, no gender-attributable differences in disease activity or physical function over time were found. However, radiographic damage was more severe in males. Furthermore, males had a better QoL over time.

title: Gender-attributable differences in outcome of XXXX : long-term results from the Outcome in @entity1691 International Study.

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['Ankylosing Spondylitis']

answer: @entity1691 :: (MESH:D013167,Disease) :: ['ankylosing spondylitis']


abstract: OBJECTIVE: To assess the effect of @entity1745 upon remote motor unit function in @entity1 with @entity3799 ( @entity3799 ). METHODS: Fifty-three @entity3799 @entity1 and 47 healthy subjects were included. Bilateral motor unit number estimations (MUNEs) were recorded from both abductor digiti minimi and abductor pollicis brevis, and bilateral flexor carpi radialis (FCR) @entity8108 -reflexes were examined in all subjects along with the @entity937 ( @entity937 ). The main outcome measures included the number of motor units, the average single motor unit potential (SMUP) area, the FCR Hmax/Mmax ratio and the @entity937 time. RESULTS: Statistically significant results compared to healthy controls included increased average SMUP area, increased FCR Hmax/Mmax ratio and increased @entity937 time (P<0.05). Abnormal SMUP was observed in 10/53 (18.9%) @entity3799 @entity1 along with reduced motor units in 3 of these 10 @entity1 , while the FCR Hmax/Mmax ratios in the @entity3799 @entity1 with abnormal MUNE were higher than those in others (P<0.05). There was a positive correlation between the @entity937 time and the average SMUP area, and a negative correlation was noted between the @entity937 time and the number of motor units (P<0.05). CONCLUSION: In @entity3799 @entity1 , the motor units below the level of compression may exhibit dysfunction, which is likely a result of @entity10747 . Both cervical @entity1566 and this @entity10747 contribute to the impairment of fine motor ability in @entity3799 @entity1 . Therefore, treatment and rehabilitation efforts should account for these two dysfunctions.

title: Trans-Synaptic Degeneration of Motoneurons XXXX in @entity3799 .

entities_list: @entity10747 :: ('MESH:D012183', 'Disease') :: ['trans-synaptic degeneration']

entities_list: @entity937 :: ('MESH:D012167', 'Disease') :: ['NHPT', 'nine-hole peg  test']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['chronic cervical spinal cord compression']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['CSM', 'cervical spondylotic myelopathy']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord compressive injury']

answer: @entity1745 :: (MESH:D013117,Disease) :: ['Distal to Chronic Cervical Spinal Cord Compression']


abstract: OBJECTIVE: To evaluate the therapeutic action and safety of @entity12802 , a new non steroidal anti-inflammatory drug, in 2 oral daily dose regimens of 8 and 16 mg in comparison with oral @entity3522 150 mg/day in @entity1 with @entity309 . METHODS: Double blind double-dummy cross-over, controlled trial. The two treatments were given for ten-day periods, separated by a three-day wash-out interval. @entity1 of both sexes with classical or definite @entity309 according to the A.R.A. criteria were enrolled in the study. RESULTS: Fourteen @entity1 (12F, 2M) were admitted, mean age 61.6 years +/- 6.7 (+/-SD), duration of illness 12.7 years +/- 11.9. @entity12802 8 and 16 mg/day showed a good therapeutic activity, comparable with @entity3522 150 mg/day. Two @entity1 complained adverse events with @entity3522 . CONCLUSIONS: @entity12802 16 mg/day was associated with a more sharp action and a better tolerability than @entity3522 in @entity309 . The twice a day dosage of @entity12802 revealed to be appropriate.

title: [Analgesic dose range finding of @entity12802 compared to XXXX . Crossover double blind study in @entity309 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

entities_list: @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac']

entities_list: @entity12802 :: ('MESH:C059451', 'Chemical') :: ['Lornoxicam', 'lornoxicam']

answer: @entity3522 :: (MESH:D004008,Chemical) :: ['diclofenac']


abstract: BACKGROUND: Following @entity64 it is common to exhibit @entity51 . @entity34 ( @entity34 ) is a rehabilitation technique used to promote use of the more affected hand via constraint of the less affected hand. One factor that could impact the outcome following @entity34 is hand dominance. Years of preferred use of one hand may give individuals with the dominant hand affected by @entity64 an advantage in improving the mobility of the more affected hand compared to those individuals with the nondominant hand affected by @entity64 . In addition, the diminished use of the less affected hand during @entity34 may also create changes. OBJECTIVE: Our goal was to better understand how hand dominance may influence the response to a @entity34 program both cortically and behaviorally in both the more affected hand and less affected constrained hand. METHODS: A repeated measures design with a double baseline was used to assess changes in clinical tests and functional magnetic resonance imaging (fMRI) in individuals with their dominant or nondominant hand affected by @entity64 involved in a @entity34 program. RESULTS: No significant differences were found between groups in their responses to @entity34 . Overall subjects demonstrated behavioral and cortical changes with the more affected hand and the less affected constrained hand did not significantly change. CONCLUSION: @entity34 promotes improvement of the more affected hand particularly on complex tests without decrements to the less affected constrained hand. Cortically, statistically significant changes in activation were noted after the intervention for the more affected hand; no changes were noted with the less affected constrained hand.

title: The influence of hand dominance on the response to a constraint-induced therapy program following XXXX .

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['deficits in mobility of the upper extremity']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['Constraint-induced therapy', 'CIT']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: BACKGROUND: The randomized controlled trial in which both the @entity1 and the treating clinician are kept blinded to the treatment is the "gold standard" for treatment research assignment. However, in psychotherapy research, evaluations can only be single blind; thus, such studies are inherently more limited. METHODS: A 12-week, bilingual, parallel-design, controlled clinical treatment trial compared @entity308 ( @entity308 ) with a parenting education program (PEP) provided to a control group. An outpatient sample of 142 @entity1 who met DSM-IV criteria for major @entity308 was randomly assigned to @entity308 or PEP between September 2005 and May 2011. Only 110 cases were assessed at baseline and had at least 1 other treatment week of paired ratings by a therapist and a blinded independent evaluator (IE). The 17-item Hamilton Depression Rating Scale and the Clinical Global Impressions Scale were administered weekly by a therapist and every 4 weeks by a blinded IE. We examined cross-informant agreement on ratings of mood and global improvement and severity. RESULTS: Nonblinded therapists consistently rated the @entity308 treatment group as more improved than the PEP control group throughout treatment, whereas the ratings by the blinded IE were significantly higher than the therapist ratings, indicating less improvement in the @entity308 group compared with the control group. The ratings suggest that rater bias may have caused the therapist raters to perceive subjects as more improved because of the expectation that @entity308 would be more effective than the PEP control condition. CONCLUSION: Ratings in psychotherapy research must be made by anonymous participation in treatment and an independent clinical evaluator who is blind to all therapy. (Journal of Psychiatric Practice 2015;21:114-123).

title: Disagreement between Therapist Raters and Independent Evaluators in a Controlled Clinical Trial of Interpersonal Psychotherapy for Depressed Pregnant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['interpersonal psychotherapy for antepartum depression', 'IPT-P', 'depressive disorder']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: BACKGROUND AND AIM OF THE STUDY: The ascending @entity384 may progress after aortic valve replacement (AVR) in bicuspid aortic valve (BAV) @entity1 . Our aim was to evaluate rheological flow patterns and histological characteristics of the aneurysmal aorta in BAV @entity1 at the time of reoperative aortic surgery. MATERIALS AND METHODS: 13 @entity1 (mean age: 42        9 years, 10 (77%) male) with significant progression of proximal aortopathy after isolated AVR surgery for BAV disease (i.e., 16.7        8.1 years post-AVR) were identified by cardiac phase-contrast cine magnetic resonance imaging (MRI) in our hospital. A total of nine @entity1 (69%) underwent redo aortic surgery. Based on the MRI data, the aortic area of the maximal flow-induced stress (jet sample) and the opposite site (control sample) were identified and corresponding samples were collected intraoperatively. Histological sum-score values [i.e. aortic wall changes were graded based on a summation of seven histological criteria (each scored from 0 to 3)] were compared between these samples. RESULTS: Mean proximal aortic diameter at MRI follow-up was 55        6  mm (range 47-66mm). Preoperative cardiac MRI demonstrated eccentric systolic flow pattern directed towards right-lateral/right posterior wall of the proximal aorta in 9/13 (69%) @entity1 . Histological sum-score values were significantly higher in the jet sample vs control sample (i.e., 8.3        3.8 vs 5.6        2.4, respectively, p   =   0.04). CONCLUSIONS: Hemodynamic factors may still be involved in the late progression of @entity4503 even after isolated AVR surgery for BAV disease.

title: Late post-AVR progression of XXXX : link to hemodynamics.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['aortic dilatation']

entities_list: @entity4503 :: ('MESH:C562388', 'Disease') :: ['bicuspid aortopathy']

answer: @entity4503 :: (MESH:C562388,Disease) :: ['bicuspid aortopathy']


abstract: @entity751 consists of @entity12737 , @entity1610 , and @entity1283 , and has been reported in 18 @entity1 to date. We report an @entity1 with @entity751 . In addition to typical findings, he had relatively mild radiological and cardiological manifestations. Previously undescribed findings included pyloric @entity850 and elevated alkaline phosphatase levels. Brain scans showed bilateral calcification of the Arteriae thalamostriatae and widening of the outer liquor spaces and lateral ventricles. Because the propositus is the youngest @entity1 reported to date, our findings refine the clinical spectrum of @entity751 in neonates and young @entity1 . The etiology and mode of inheritance of @entity751 are unknown. Most cases are sporadic. Microdeletions have been discussed as a possible cause of @entity751 . Recently, several syndromes with @entity154 and @entity1032 have been shown to be caused by @entity2008 . We excluded the presence of a cryptic @entity2008 in our @entity1 by fluorescence in situ hybridization (FISH) screening with locus-specific probes.

title: Further case of XXXX : exclusion of cryptic @entity2008 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'infants', 'infant']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['multiple congenital anomalies']

entities_list: @entity1610 :: ('MESH:D010009', 'Disease') :: ['osteochondrodysplasia']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiomegaly']

entities_list: @entity12737 :: ('MESH:D006983', 'Disease') :: ['hypertrichosis']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['Cant   syndrome']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['subtelomeric chromosome aberrations', 'subtelomeric chromosome anomaly']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity751 :: (MESH:D013577,Disease) :: ['Cant   syndrome']


abstract: RATIONALE: @entity320 ( @entity320 ) is the cutaneous @entity5 with the greatest mortality rates and one of the @entity5 with the highest potential of dissemination. The prognosis of @entity1 with metastatic @entity320 is grim, with a 5-years survival rate between 5-19%, and is dictated by the location and the number of @entity3 . OBJECTIVE: We aimed to estimate the survival of @entity1 with metastatic @entity320 from our study and find out if the @entity3 ' location influences survival. METHODS AND RESULTS: Between 2008 and 2013, 155 @entity1 with cutaneous @entity320 were diagnosed in our clinic. All the @entity1 were staged according to 2009 AJCC staging system. The median follow-up period was of 24 months. Survival was calculated by using the Kaplan-Meier method with a confidence level of 95%. 40.5% of the @entity1 developed @entity3 in different organs, especially the brain. 80.6% of those with @entity3 died during the study. The median overall survival, estimated for the entire group of @entity1 who developed @entity3 , was of 5.3 months. DISCUSSION: The influence of @entity3 distribution on the overall survival was examined and it was noticed that there were statistically significant differences between the risks of @entity204 of various groups of @entity1 , depending on @entity3 topography. Thus, the @entity204 probability of a @entity1 with brain @entity3 is twice that of a @entity1 with digestive @entity3 , about 7 times higher than that of a @entity1 with lung @entity3 (p = 0.0004) and 12 times higher than the @entity204 risk of a @entity1 with extra-regional lymph nodes or subcutaneous @entity3 (p = 0.0000).

title: Survival rates of XXXX with metastatic @entity320 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia', 'malignancies']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['Malignant melanoma', 'MM']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES: @entity4185 ( @entity4185 ) treatment has been shown to increase the risk of @entity1576 in @entity1 with stable @entity1030 ( @entity1030 ). However, the effects of perioperative @entity4185 treatment on @entity260 after @entity2 surgery have not been elucidated. The aim of this study was to investigate whether perioperative @entity4185 treatment would increase the risk of @entity260 after @entity2 surgery in @entity1 with @entity1030 . METHODS: We retrospectively analyzed 174 consecutive @entity1030 @entity1 with @entity1149 ( @entity1149 ) who underwent lobectomy or segmentectomy between January 2007 and December 2014. Subjects were grouped based on whether or not they were administered perioperative @entity4185 treatment. @entity260 were compared between the groups. RESULTS: There were no statistically significant differences in the incidence of @entity260 (P  =  0.573) between the perioperative @entity4185 treatment group (n  =  16) and the control group (n  =  158). Perioperative @entity4185 treatment was not significantly associated with @entity260 in the univariate or multivariate analysis (odds ratio [OR]  =  0.553, 95  % confidence interval [CI]  =  0.069-4.452, P  =  0.578; OR  =  0.635, 95  % CI  =  0.065-6.158, P  =  0.695, respectively). Kaplan-Meier analysis showed that there were no statistically significant differences in the @entity260 -free durations between the groups (P  =  0.566), even after propensity score matching (P  =  0.551). CONCLUSION: There was no relationship between perioperative @entity4185 administration and the incidences of @entity260 after surgical resection for @entity1149 in @entity1030 @entity1 .

title: The relationship between perioperative administration of inhaled XXXX after pulmonary resection for @entity1149 in @entity1 with @entity1030 .

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative respiratory complications', 'Postoperative cardiopulmonary complications']

entities_list: @entity4185 :: ('MESH:D058545', 'Disease') :: ['Inhaled corticosteroid', 'ICS']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory complications']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

answer: @entity260 :: (MESH:D011183,Disease) :: ['corticosteroid and postoperative respiratory complications']


abstract: Objective. The aim of this study was to assess the ultrasonographic (US) findings of pes anserinus tendon and bursa in @entity1 with @entity626 ( @entity571 ) with or without clinical pes anserinus @entity2585 (PATBS). Methods. A total of 157 female @entity1 with the diagnosis of knee @entity571 on both knees (314 knees), and 30 age, and body mass index- matched healthy female controls without knee @entity158 (60 knees), were included in the study. PATBS was clinically diagnosed. US evaluation parameters were the measurement of the thickness of pes anserinus tendon insertion region (PA) and examination of the morphologic intratendinous PA tissue characteristics and @entity2585 ( @entity2585 ). @entity626 graded I-IV according to Kellgren and Lawrence (KL) for each knee was recorded. @entity158 and functional status were assessed by the Visual Analog Scale (VAS) and Western Ontario and McMaster Universities @entity571 Index (WOMAC). Results. There were 183 PATBS (58.3%) clinical diagnoses among the 314 knees with @entity571 . The mean thickness of PA in the @entity1 with knee @entity571 graded 1,2,3,4 with/without PATBS was significantly greater than the controls (p = 0.001). The mean thickness of PA in knees with @entity571 KL graded 3 and 4 with/without PATBS, was greater than knees with @entity571 KL graded 1 and 2 with/without PATBS (p < 0,05) (except knee @entity571 KL graded 2 with PATBS versus knee @entity571 KL graded 4 without PATBS).The knee @entity571 KL graded 1,2,3,4 with PATBS had significantly more @entity2585 and less loss of normal fibrillar echotexture of PA compared to controls and knees with @entity571 KL graded 1,2,3,4 without PATBS (p < 0.05). The VAS scores of knees with @entity571 KL graded 3, 4 with PATBS were significantly greater than those of knees with @entity571 KL graded 3,4 without PATBS (p < 0.05). PA thickness was significantly associated with the KL grade (r: 0.336, p:0.001) and PATBS (r: 0.371, p < 0.001). Conclusion. It is concluded that the mean thickness of PA in knees with @entity571 with/without PATBS was significantly greater than the controls. The mean thickness of PA in knees with @entity571 , KL graded 3 and 4 with/without PATBS, was greater than in knees with @entity571 KL graded 1 and 2 with/without PATBS. The knee @entity571 with PATBS had significantly more @entity2585 , less loss of normal fibrillar echotexture of PA, and higher VAS scores compared to the knees with @entity571 without PATBS. US can serve as a useful diagnostic tool for detection of PATBS in knee @entity571 .

title: Ultrasonographic assessment of pes anserinus tendon and pes anserinus XXXX in @entity1 with @entity626 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis', 'Radiographic knee osteoarthritis']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis']

entities_list: @entity2585 :: ('MESH:D002062', 'Disease') :: ['PAB', 'tendinitis bursitis syndrome', 'pes anserinus bursitis']

answer: @entity2585 :: (MESH:D002062,Disease) :: ['tendinitis bursitis syndrome']


abstract: Low energy x-rays (E(ph) </=50 keV) are widely used in diagnostic radiology and radiotherapy. However, data on their relative biological effectiveness (RBE) are scarce. Of particular importance for risk estimation are the RBE values of x-rays in the range which is commonly used in mammography (10-30 keV). We have determined clonogenic survival after low-energy x-ray irradiation for three cell lines: primary @entity1 epidermal keratinocytes (HEKn), @entity19 fibroblasts (NIH/3T3) and @entity3569 fibroblasts (V79). Experiments were performed with a 25 kV x-ray tube and compared to 200 kV x-rays as a reference. Compared to the effect of 200 kV x-rays, irradiation with 25 kV x-rays resulted in a decreased survival rate in the @entity19 fibroblasts, but not in the @entity1 epithelial cell line. The RBE value was calculated for 10% surviving fraction. For HEKn cells, RBE was 1.33+/-0.27, for NIH/3T3 cells 1.25+/-0.07 and for V79 cells 1.10+/-0.09, respectively. No consistently increased RBE was observed in the various cell lines. Nevertheless, a potential of increased cytogenetic changes has to be considered for risk estimation of low-energy x-rays.

title: Clonogenic survival of XXXX keratinocytes and rodent fibroblasts after irradiation with 25 kV x-rays.

entities_list: @entity3569 :: ('10029', 'Species') :: ['Chinese hamster']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Age-related @entity393 (ARHL) represents one of the most common chronic health problems that faces an aging population. In the peripheral auditory system, aging is accompanied by functional loss or @entity528 as well as non-sensory tissue. It has been recently described that besides the degeneration of cochlear structures, the central auditory system is also involved in ARHL. Although mechanisms of central presbycusis are not well understood, previous animal studies have reported some signs of @entity179 in the lower auditory pathway. Moreover, changes in neurophysiology are indicated by alterations in synaptic transmission. In particular, neurotransmission and spontaneous neuronal activity appear to be affected in aging animals. Therefore, it was the aim of the present study to determine the neuronal activity within the central auditory pathway in aging @entity19 over their whole lifespan compared to a control group (young adult animals, ~3months of age) using the non-invasive @entity921 -enhanced MRI technique. MRI signal strength showed a comparable pattern in most investigated auditory brain areas. An increase in activity was particularly pronounced in the middle-aged groups (13 or 18months), with the largest effect in the dorsal and ventral cochlear nucleus. In higher auditory structures, namely the inferior colliculus, medial geniculate body and auditory cortex, the enhancement was much less expressed; while a decrease was detected in the superior olivary complex. Interestingly, @entity460 -dependent activity reduced to control levels in the oldest animals (22months) in the cochlear nucleus and was significantly reduced in higher auditory structures. A similar finding was also found in the hippocampus. The observed changes might be related to central neuroplasticity (including hyperactivity) as well as neurodegenerative mechanisms and represent central nervous correlates of the age-related decline in auditory processing and perception.

title: Age-dependent changes of XXXX related activity in the central auditory pathway.

entities_list: @entity921 :: ('MESH:D008345', 'Chemical') :: ['manganese']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['central neurodegeneration']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration of sensory']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: The @entity377 distribution of all 33,527 open reading frames (ORFs) (> or =300 bp) in the genome of @entity45743 ) has been analyzed using the Z curve method. Each ORF is mapped onto a point in a 9-dimensional space. To visualize the distribution of mapping points, the points are projected onto the principal plane based on principal component analysis. Consequently, the distribution pattern of the 33,527 points in the principal plane shows a flower-like shape, in which there are seven distinct regions. In addition to the central region, there are six petal-like regions around the center, one of which corresponds to 7172 coding sequences. The central region and the remaining five petal-like regions correspond to the intergenic sequences and out-of-frame non-coding ORFs, respectively. It is shown that selective pressure produces a remarkable bias of the G+C content among three codon positions, resulting in the interesting phenomenon observed. A similar phenomenon is also observed for other bacterial genomes with high genomic G+C content, such as @entity5175 (G+C = 66.6%). However, for the genomes of @entity3881 (G+C = 43.5%) and @entity3168 (G+C = 28.6%), no similar phenomenon was observed. The finding presented here may be useful to improve the gene-finding algorithms for genomes with high G+C content. A set of supplementary materials including the plots displaying the base distribution patterns of ORFs in 12 prokaryotes is provided on the website http://tubic.tju.edu.cn/highGC/.

title: Analysis of XXXX distribution in the genome of @entity45743 ) using the Z curve method.

entities_list: @entity5175 :: ('208964', 'Species') :: ['Pseudomonas aeruginosa PA01']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity3168 :: ('1502', 'Species') :: ['Clostridium perfringens']

entities_list: @entity45743 :: ('100226', 'Species') :: ['Streptomyces coelicolor A3(2']

entities_list: @entity3881 :: ('1423', 'Species') :: ['Bacillus subtilis']

answer: @entity377 :: (CHEBI:36976,Chemical) :: ['nucleotide']


abstract: BACKGROUND: Sensory-processing deficits appear crucial to the clinical expression of symptoms of @entity161 . The @entity227 both dysconnectivity and aberrant spontaneous activity in @entity1 with persistent symptoms and @entity73 . In this paper, we examine visual cortex in the context of the remerging notion of @entity9479 in @entity161 . We examined specific regional and longer-range @entity9479 in @entity161 , and whether these patterns are strong enough to discriminate symptomatic @entity1 from controls. METHOD: Using publicly available resting fMRI data of 71 controls and 62 @entity161 @entity1 , we derived conjunction maps of regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF) to inform further seed-based Granger causality analysis (GCA) to study effective connectivity patterns. ReHo, fALFF and GCA maps were entered into a multiple kernel learning classifier, to determine whether patterns of local and effective connectivity can differentiate controls from @entity1 . RESULTS: Visual cortex shows both ReHo and fALFF reductions in @entity1 . Visuothalamic effective connectivity in @entity1 was significantly reduced. Local connectivity (ReHo) patterns discriminated @entity1 from controls with the highest level of accuracy of 80.32%. CONCLUSIONS: Both the inflow and outflow of Granger causal information between visual cortex and thalamus is affected in @entity161 ; this occurs in conjunction with highly discriminatory but localized dysconnectivity and reduced neural activity within the visual cortex. This may explain the @entity227 that are present despite symptomatic remission in @entity161 .

title: Abnormalities in the effective connectivity of visuothalamic circuitry in XXXX .

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-processing deficits', 'visual cortex displays']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity9479 :: ('MESH:D013786', 'Disease') :: ['thalamic dysfunction', 'abnormalities in sensory and thalamic circuits']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: We analysed the outcome of 200 @entity1 , aged 38 (13-72) years, with aggressive @entity1893 ( @entity1893 ) treated with high-dose chemotherapy followed by autologous haematopoietic stem cell transplantation (autoHSCT) in ten oncohaematological centres belonging to Polish Lymphoma Research Group (PLRG). The source of stem cells for transplantation was peripheral blood (autoPBSCT, n = 153), bone marrow (autoBMT, n = 40) or both blood and bone marrow (n = 7). The probability of @entity1349 ( @entity1349 ) and progression-free survival at 10 years was 51% (+/- 7%). The transplant-related mortality rate equalled 7%. In multivariate analysis, the only factor influencing independently the probability of @entity1349 was disease status at transplantation (p < 0.00001). The outcome of @entity1 transplanted in first or subsequent complete remission or first partial remission (PR) was significantly better compared with subjects given autoHSCT in PR 2 or those with primary or secondary refractoriness. Regarding histological subtypes, the highest @entity1349 rate (87%) was observed for anaplastic large @entity784 . The outcome after autoBMT was better compared with autoPBSCT ( @entity1349 probability: 67% vs. 43%), although the difference did not reach statistical significance. We conclude that high-dose therapy followed by autoHSCT is an effective option for high-risk aggressive @entity1893 . Remission status is a major factor determining long-term outcome. This should be taken into account when referring @entity1 for autoHSCT.

title: [Autologous hematopoietic stem cell transplantation for the treatment of aggressive XXXX . The experience of Polish lymphoma research group].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell lymphoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']


abstract: BACKGROUND: Increased proliferation of @entity3960 ( @entity3960 ) cells leading to @entity1373 and increased @entity3960 mass is one of the most characteristic features of airway remodelling in @entity565 . A bioactive lipid, @entity5595 ( @entity5596 ), has been suggested to affect airway remodelling by stimulation of @entity1 @entity3960 cell proliferation. OBJECTIVE: To investigate the effect of @entity5596 on signalling and regulation of gene expression in @entity3960 cells from healthy and @entity748 individuals. METHODS: Airway smooth muscle cells grown from bronchial biopsies of healthy and @entity748 individuals were exposed to @entity5596 . Gene expression was analysed using microarray, real-time PCR and Western blotting. Receptor signalling and function were determined by mRNA knockdown and intracellular @entity460 mobilization experiments. RESULTS: @entity5596 potently regulated the expression of more than 80 genes in @entity1 @entity3960 cells, including several genes known to be involved in the regulation of cell proliferation and airway remodelling ( @entity20107 , @entity1934 , @entity24771 , @entity10431 , @entity2289 , @entity35344 ). @entity5596 acting through @entity63531 receptors activated intracellular @entity460 mobilization and extracellular signal-regulated and Rho-associated kinases to regulate gene expression. @entity5596 -induced responses were not inhibited by @entity288 and did not differ significantly between @entity3960 cells from healthy and @entity748 individuals. CONCLUSION: @entity5596 induces a @entity134 -resistant, pro-remodelling pathway in @entity3960 cells. Targeting @entity5596 or its receptors could be a novel treatment strategy for inhibiting airway remodelling in @entity565 .

title: XXXX induces pro-remodelling response in @entity3960 cells.

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity3960 :: ('MESH:D018235', 'Disease') :: ['airway smooth muscle', 'ASM']

entities_list: @entity5595 :: ('MESH:C060506', 'Chemical') :: ['sphingosine-1-phosphate']

answer: @entity5595 :: (MESH:C060506,Chemical) :: ['Sphingosine-1-phosphate']


abstract: CONTEXT: Small for gestational age (SGA) subjects experience pre- and postnatal growth restriction, which might be influenced by polymorphisms in the @entity442 gene. The well-known -841(CA)(n)/192 bp polymorphism has been associated with birth size, @entity65 , and @entity442 levels, and is in linkage disequilibrium with the - @entity67167 single nucleotide polymorphism (SNP; @entity42670 ). OBJECTIVE: To associate the - @entity67167 SNP with head circumference (HC) and brain sparing (a greater head compared with height @entity214 ) in short SGA and SGA catch-up subjects. DESIGN: Gene association study. @entity1 : We studied 635 SGA subjects out of which 439 remained short and 196 had a postnatal height >-2.00 @entity214 . MEASUREMENTS: The - @entity67167 SNP @entity442 gene polymorphism and head size. RESULTS: All SGA subjects had a postnatal head size below the population mean (-1.01 @entity214 , P<0.001). Whereas SGA catch-up subjects had a head size that was in proportion with their height, short SGA subjects displayed extensive brain sparing (HC - height: SGA CU: 0.01 versus short SGA: 1.75 @entity214 , P<0.001). The most severely SGA born subjects had a 0.4 @entity214 smaller postnatal head size and 0.6 @entity214 less brain sparing when carrying the -1245 A-allele in contrast to G-allele carriers (P=0.03). The association between the - @entity67167 SNP and head size remained significant after correction for birth weight and postnatal height @entity214 (P=0.03). Birth weight, birth length and postnatal height @entity214 were not related with the - @entity67167 SNP. CONCLUSIONS: The -1245 A-allele of the @entity442 promoter SNP is associated with a small head size and less brain sparing in SGA born subjects and particularly those with the lowest birth weight.

title: The - XXXX @entity442 polymorphism is related with small head size and less brain sparing in small for gestational age born @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity67167 :: (c|SUB|G|1245|A,DNAMutation) :: ['G1245A']


abstract: BACKGROUND: The optimal sizing of self-expanding @entity1311 -eluting stents (PES) in the treatment for superficial femoral artery (SFA) lesions is unclear. This study sought to investigate the influence of PES diameter on stent patency in SFA lesions using optical frequency domain imaging (OFDI). METHODS: A total of 20 de novo SFA lesions were randomized 1:1 to receive either self-expanding PES with a nominal diameter of 6mm or 8mm. Follow-up angiography and OFDI was scheduled six months after stent implantation, and volumetric OFDI analysis was performed to evaluate vascular response to the stents. Volume index (VI) was defined as the volume divided by the stent length. The primary end point was lumen VI at the 6-month follow-up. Secondary end point was @entity5562 ( @entity5562 ) by quantitative vascular angiography (QVA) at the follow-up. RESULTS: Stent length was 78.0  23.9mm in the 6-mm group and 70.0  23.6mm in the 8-mm group (p=0.46). Baseline QVA data were also similar between the two groups. @entity5562 immediately after stent implantation was similar between the two groups (4.2  0.5mm in the 6-mm group and 3.9  0.5mm in the 8-mm group, p=NS). At the 6-month follow-up, @entity5562 was greater in the 8-mm group compared to the 6-mm group (4.0  1.0mm vs. 3.2  0.4mm, p<0.05). Stent VI was larger in the 8-mm group (28.4  6.7mm(3)/mm vs. 22.2  1.2mm(3)/mm, p=0.01). Neointimal VI was similar between the two groups (5.8  2.9mm(3)/mm vs. 5.2  2.6mm(3)/mm, p=0.68). Lumen VI was greater in the 8-mm group (23.2  7.6mm(3)/mm vs. 17.3  2.6mm(3)/mm, p=0.04). CONCLUSIONS: Chronic stent enlargement resulted in greater lumen area after implantation of self-expanding PES with a large diameter at the mid-term follow-up. Stent diameter might be important for stent patency in procedure with PES for SFA lesions.

title: Impact of stent diameter on vascular response after self-expanding XXXX -eluting stent implantation in the superficial femoral artery.

entities_list: @entity5562 :: ('MESH:D015875', 'Disease') :: ['MLD', 'minimum lumen diameter']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

answer: @entity1311 :: (MESH:D017239,Chemical) :: ['paclitaxel']


abstract: The aim of this paper was to evaluate the influence of bone invasion on treatment outcome among @entity1 with @entity5 of the oral cavity and oropharynx and to determine whether or not outcome was influenced by the extent of mandibular resection. A review of 127 prospectively documented @entity1 who were treated with marginal or segmental resection for oral (n = 110) and oropharyngeal (n = 17) @entity5 was undertaken. There were 97 males and 30 females with a median age of 61 years. Clinical T stages were: T1 17 @entity1 , T2 33, T3 22, T4 55. Median followup was 4 years. A total of 94 @entity1 underwent marginal resections and 33 underwent segmental resections. Histological bone invasion was present in 17 @entity1 (16%) in the marginal resection group and 21 @entity1 (64%) in the segmental group (P<0.05). Soft tissue surgical margins were positive in 11 @entity1 (12%) in the marginal group and in seven @entity1 (21%) in the segmental group (P=not significant). Local control did not correlate significantly with T stage, the extent of mandibular resection or the presence of histological bone invasion, but was significantly influenced by positive soft tissue margins (P<0.01). Among @entity1 with bone invasion, the local control rate was higher following segmental resection when compared to marginal resections (87% vs 75%) but this was not statistically significant. Survival was significantly influenced by positive soft tissue margins but not bone invasion or the type of resection. We conclude that bone invasion alone did not predict for local control or survival rates among @entity1 with oral and @entity5 . Involved soft tissue margins were highly predictive of local recurrence and decreased survival. Conservative resection of the mandible is safe as long as marginal mandibulectomy does not lead to compromise of soft tissue margins. Segmental resection should be reserved for @entity1 extensive bone invasion or those with limited invasion in a thin @entity3202 mandible.

title: Influence of bone invasion and extent of mandibular resection on local control of XXXX of the oral cavity and oropharynx.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['oropharyngeal cancers', 'cancers']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancers']


abstract: BACKGROUND: The @entity1 -centered medical home (PCMH) concept requires collaboration among clinicians both within the medical home clinic, and outside the clinic. As we redesign @entity283 ( @entity283 ) to support transformation to the PCMH, we need to better understand these collaboration patterns. This study provides quantitative data describing these collaborations in order to facilitate the design of systems to allow for more efficient collaboration. APPROACH: Eighty-four clinicians in eight clinics identified their two most recent significant collaborators - one each within the clinic and in the medical neighborhood. They also identified the communication channels used in these collaborations. We used k-means clustering to identify communication patterns. RESULTS: Within the clinic, half of the primary care providers (PCPs) identified a care manager as their most recent collaborator. Outside specialists were their most common external collaborators. Ninety-two percent of the non- @entity4426 @entity1 identified @entity4426 's as their most recent internal collaborators. The best model for communication channel usage (p < .0001) had six clusters. In general, inside communications were more informal but outside collaborations were more often formal written communications (faxes, letters) or the exchange of electronic health record progress notes. But there were exceptions to these patterns and in many cases multiple channels were used for the same collaboration. CONCLUSION: Systems design (and redesign) needs to focus on reducing communications load and increasing communication effectiveness while maintaining flexibility.

title: Collaborators and Communication Channels in Eight XXXX -Centered Medical Homes.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patient']

entities_list: @entity283 :: ('OMIM:603663', 'Disease') :: ['HIT', 'health information technology']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: Radiation therapy can be an effective means to treat bone @entity3 , which occur in more than 50% of @entity5 @entity1 . (153)Samarium lexidronam ((153)Sm-EDTMP; Quadramet, Cytogen) is a radiopharmaceutical designed for deposition into bone @entity3 . Bone scans can identify @entity1 that may benefit from targeted radiation therapy with (153)Sm-EDTMP. As an unsealed source of radiation therapy, (153)Sm-EDTMP is simple to administer: 1 mCi/kg is given in a similar fashion to a bone scan injection ( @entity32621 bone scan injection is given at 0.2-0.35 mCi/kg. Therefore, both are administered intravenously. However, the radiation-absorbed dose and radiopharmaceutical energy are different). Nevertheless, despite simplicity of administration, (153)Sm-EDTMP is underutilized for improving @entity5 in the skeleton. Repeated cycles and combined treatment with other modalities such as @entity171 , chemotherapy and/or external beam radiation are possible. (153)Sm-EDTMP combined with @entity171 , chemotherapy and/or radiation may provide better palliation of bone @entity3 and also in bone-forming @entity5 ( @entity421 ). Encouraging experience using high-dose (153)Sm-EDTMP for @entity236 in @entity1583 involving the bones (e.g., @entity1582 or @entity3052 ) is also reviewed.

title: Samarium lexidronam (153Sm-EDTMP): skeletal radiation for osteoblastic bone @entity3 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity171 :: ('MESH:D004164', 'Chemical') :: ['bisphosphonates']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cancer pain', 'tumors']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['total marrow irradiation']

answer: @entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']


abstract: Objectives are to validate a simple classification for irradiated specimens and assessing the incidence and the outcome of sterilized forms. Between 1996 and 2005, 56 non metastatics @entity1 had preoperative chemoradiation and curative resection for @entity788 . We retrospectively applied the Dworak regression scale previously describe for @entity5 . Dworak 4 (sterilized @entity5 ), 3, 2, 1 and 0 grades interested 7 (12,5%), 12, 12, 11 and 14 @entity1 respectively. The median estimated overall survival of all @entity1 was 24 months with estimated 1-, 3- and 5-year survivals of 80%, 35% and 18% respectively. Statistical analysis permitted to regroup @entity1 classified Dworak 4 or 3 (grade 2 of our modified Dworak classification (MDC)) and Dworak 2, 1 or 0 (grade 1 of our MDC). @entity1 with grade 2 MDC had an estimated median survival and 5-years survival of 40 months and 28 % respectively. Eleven @entity1 (58%) with grade 2 MDC (n = 19) had exclusive metastatic recurrences. Nineteen @entity1 with grade 1 MDC (n = 37) had metastatic (n = 17 ; 46% ; p = 0,07) or local recurrences (n = 2). The MDC was useful because a) easy to used and b) correlated with good prognostic factor for @entity1 with grade 2 MDC. However, metastatic recurrence rate didn't differed in the 2 groups. Thus, @entity420 had to be treated by surgical curative resection associated with radiotherapy and systemic chemotherapy to control the both side, metastatic and local, of the disease. The best preoperative treatment had to be define but must include CRT and systemic chemotherapy.

title: [A modified Dworak classification applied to XXXX : a useful prognostic factor].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic adenocarcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma of the pancreas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']


abstract: Between March 1983 and December 1989 a total of 57 pancreas transplants were performed in 54 @entity1 , of whom 49 also received a kidney for end-stage @entity2316 . Of the surviving 44 @entity1 , 39 had regular pre-operative and post-operative ophthalmological examinations. @entity6 was classified according to the original "Early treatment @entity6 study" (ETDRS) protocol. At the time of this analysis a total of 25 @entity1 had a functioning pancreas transplant and 23 of them also a functioning renal allograft after a mean observation time of 43.2 months (Group 1). They were all free of exogenous insulin, @entity4051 c being 6.2% (5.1-6.9%; normal value 4.2-5.9%). Fourteen @entity1 in Group 2 lost their pancreas transplant during the first four years. Six of them still have a functioning renal allograft, four @entity1 regularly undergo hemodialysis. Mean @entity4051 c is 7.5% (5.7-9.2%). Before transplantation, grade of @entity989 according the ETDRS protocol was 6.7 (2-10) in group 1 @entity1 and 7.9 (3-10) in group 2. In group 1 @entity1 @entity989 was observed in 33 eyes (73.3%) and clear improvement achieved in 4 eyes (8.8%). Detoriation occurred in 8 eyes (17.7%) only. In group 2, 14 eyes (54%) remained stable, whereas progression of the disease continued in 12 eyes (46%). From these results it is concluded that the course of @entity6 is positively influenced by successful pancreas transplantation.

title: Does pancreas transplantation influence the course of XXXX ?

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic retinopathy', 'diabetic retinopathy']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['stabilisation of retinopathy', 'retinopathy']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic retinopathy']


abstract: @entity1701 is associated with venous and arterial @entity1031 . Coexistence of @entity1151 and @entity715 is rarely encountered. A 33-year-old male @entity1 presented with severe @entity1353 three months after surgery for acute @entity1416 . On physical examination, blood pressure was 80/60 mmHg and breath sounds were weaker in the lower zone of the left lung. Severe lower limb @entity4 was noted. On @entity299 , the third heart sound was elicited. Electrocardiography showed only a sinusal @entity591 . Transthoracic echocardiography revealed a huge @entity715 in the right atrium and another @entity715 in the main pulmonary artery. Hematological analysis showed a high titration of antiphospholipid antibodies. A diagnosis of @entity1151 was considered. During preparation for emergency operation, the @entity1 developed @entity65 , which did not respond to cardiopulmonary resuscitation.

title: XXXX leading to @entity1151 and sudden death.

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolism']

entities_list: @entity1701 :: ('MESH:D016736', 'Disease') :: ['Antiphospholipid antibody syndrome']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['massive pulmonary embolism', 'pulmonary embolism']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac auscultation']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'intracardiac thrombus']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular collapse']

answer: @entity1701 :: (MESH:D016736,Disease) :: ['Antiphospholipid antibody syndrome']


abstract: Small bowel transplantation (SBT) has become an increasingly promising treatment for @entity5277 . The evaluation of graft viability after SBT, however, has not been established, except by mucosal biopsy. We monitored intestinal mucosal acidity in order to detect small @entity63 -reperfusion injury. Mongrel @entity235 were used in this study. After laparotomy, the small bowel was isolated with a vascular pedicle. A tonometer to measure intramucosal pH (pHi) was then positioned in the terminal ileum. The superior mesenteric artery was occluded with or without concomitant superior mesenteric vein occlusion for 60 or 120 min. The value of pHi was determined from laparotomy (baseline) to 12 h after reperfusion. Whole-thickness specimens of the ileum were taken before @entity63 , just before reperfusion, and 1 h afterward. @entity3137 was graded histopathologically. pHi decreased from baseline in relation to the degree of @entity3137 . There was a significant correlation between histological findings and the change in pHi. We conclude that monitoring intestinal mucosal acidity is a reliable way of determining graft viability after SBT.

title: Intramucosal pH and intestinal mucosal damage in XXXX -reperfusion injury.

entities_list: @entity5277 :: ('MESH:D012778', 'Disease') :: ['short bowel syndrome']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['Mucosal injury', 'histopathological mucosal injury']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['intestinal ischemia', 'ischemia']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemia']


abstract: PURPOSE: To evaluate the safety and efficacy of @entity1496 125 plaque brachytherapy (IBT) for large uveal @entity320 . DESIGN: Retrospective, nonrandomized comparative trial (historical control). @entity1 : One hundred twenty-one consecutive @entity1 with a large uveal @entity320 according to the @entity320 Study (COMS) criteria who attended a national ocular oncology service. METHODS: Ninety-seven @entity1 (80%) underwent primary IBT (mean dose to @entity5 apex, 87 Gy) with noncollimated 20- to 25-mm plaques. Assessment of metastatic disease at @entity204 and visual outcome followed COMS guidelines. Time to @entity4064 (20/70 or worse) and @entity1939 ( @entity1018 ) in the study eye were modeled by Cox proportional hazards regression, based on both single- and repeated-failure data sets. @entity1 -years of retained vision were calculated. MAIN OUTCOME MEASURES: All-cause and @entity320 -specific survival, local and distant recurrence, and preservation of vision and cosmesis. RESULTS: Median @entity5 height was 10.7 mm (range, 4.5-16.8 mm), and largest basal @entity5 diameter was 16.1 mm (range, 7.3-25.0 mm). The Kaplan-Meier estimate for all-cause and @entity320 -specific survival was 62% (95% confidence interval [CI], 49%-72%) and 65% (95% CI, 52%-75%) at 5 years. The corresponding estimate for local @entity5 recurrence was 6% (95% CI, 2%-14%) and for major @entity854 was 38% (95% CI, 26%-52%). The median visual acuity in the study eye was 20/100 at baseline and 20/1600 at 2 years after treatment. The Kaplan-Meier estimate for avoiding @entity4064 and @entity1939 was 11% (95% CI, 4%-24%) and 26% (95% CI, 16%-37%) at 2 years, respectively. @entity5 height and location entirely posterior to the ora serrata were the most robust predictors of @entity227 . In this series, 49 @entity1 -years without @entity4064 (median, 0.6 years; range, 0.04-8.2 years) and 111 @entity1 -years without @entity1939 (median, 1.0 years; range, 0.03-8.6 years) in the treated eye were conserved. CONCLUSIONS: @entity1496 125 plaque brachytherapy seems to be a safe and effective alternative to enucleation with regard to survival and local @entity5 control. It provides a fair chance of preserving the eye with acceptable cosmesis and a reasonable chance of conserving useful vision for 1 to 2 years.

title: @entity1496 brachytherapy as an alternative to enucleation for large uveal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Person', 'patients', 'person', 'PARTICIPANTS']

entities_list: @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine', 'Iodine']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['cosmetic abnormality']

entities_list: @entity4064 :: ('MESH:D015354', 'Disease') :: ['low vision']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'Collaborative Ocular Melanoma', 'melanomas']

answer: @entity320 :: (MESH:D008545,Disease) :: ['melanomas']


abstract: UNASSIGNED: This paper introduces a mathematical model representing the biochemical interactions between @entity2690 signaling and @entity191 . The model can be used to examine the changes that occur over the course of the disease as well as identify which processes would be the most effective targets for treatment. The model is mathematized using biochemical systems theory (BST). It incorporates a treatment strategy that includes several experimental drugs along with current treatments. In the past, BST models of @entity179 have used power law analysis and simulation (PLAS) to model the system. This paper recommends the use of MATLAB instead. MATLAB allows for more flexibility in both the model itself and in data analysis. Previous BST analyses of @entity179 began treatment at disease onset. As shown in this model, the outcomes of delayed, realistic treatment and full treatment at disease onset are significantly different. The delayed treatment strategy is an important development in BST modeling of @entity179 . It emphasizes the importance of early diagnosis, and allows for a more accurate representation of disease and treatment interactions.

title: A mathematical model of XXXX resistance in @entity191 .

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

answer: @entity2690 :: (3630,Gene) :: ['insulin']


abstract: BACKGROUND: Cellular @entity12878 has been associated with a more aggressive course than classic @entity12878 , including local recurrences and @entity3 . OBJECTIVE: To define the clinicopathologic and imaging features distinguishing cellular from classic @entity12878 . MATERIALS AND METHODS: Retrospective review of clinical charts and imaging studies of ten @entity1 with @entity12878 from 1996 to 2007 at a large @entity1 's hospital. RESULTS: In six @entity1 the @entity12878 was pure cellular, in two mixed, and in two classic. The mean ages at diagnosis were 107 days for those with the cellular form, and 32 days for those with the classic form. Hypoechoic or low-attenuation regions representing @entity39 or @entity548 were found in all @entity1 with the cellular form and in none of those with the classic form. @entity101 was present in 70% and @entity2741 in 20% of the @entity1 and resolved following nephrectomy. Two cellular @entity5 encased major abdominal vessels. Local recurrence and @entity3 occurred within 6 months of @entity5 resection in two @entity1 with the cellular form. Intraspinal extension and intratumoral @entity2849 were seen in one @entity1 with the cellular form. The cellular @entity5 shared histopathologic features with @entity1492 ( @entity1492 ), and RT-PCR testing in two @entity1 with the cellular form revealed the t(12;15) @entity9604 - @entity13820 gene fusion common to @entity1492 . CONCLUSION: Distinct from the classic form, cellular @entity12878 is more heterogeneous in appearance on imaging, tends to be larger and present later in infancy, and can exhibit aggressive behavior including vascular encasement and @entity3 . Intraspinal extension and intratumoral @entity2849 are previously unreported findings encountered in our cellular @entity12878 series. The shared histopathology and translocation gene fusion support the concept of cellular @entity12878 as the renal form of @entity1492 .

title: Cellular @entity12878 (infantile renal fibrosarcoma): institutional review of the clinical, diagnostic imaging, and pathologic features of a distinctive XXXX of infancy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity12878 :: ('MESH:D018201', 'Disease') :: ['mesoblastic nephroma']

entities_list: @entity1492 :: ('MESH:D005354', 'Disease') :: ['IFS', 'infantile fibrosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

answer: @entity5 :: (MESH:D009369,Disease) :: ['neoplasm']


abstract: OBJECTIVES: To compare short- and long-term neurologic outcomes in @entity1167 treated with mild @entity2332 presenting with nonshockable versus shockable initial rhythms. DESIGN: Retrospective cohort study. SETTING: Emergency department and ICU of an academic hospital. @entity1 : One hundred twenty-three consecutive post-out-of-hospital @entity1167 adults (57 nonshockable rhythms, 66 shockable rhythms) treated with @entity2332 between 2006 and 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Data were collected from electronic health records. Neurologic outcomes were dichotomized by Cerebral Performance Category at discharge and 6- to 12-month follow-up and analyzed via multivariable logistic regressions. Groups were similar, except nonshockable rhythm @entity1 were more likely to have a history of @entity6 (p = 0.01), be dialysis dependent (p = 0.01), and not have bystander cardiopulmonary resuscitation (p = 0.05). At discharge, 3 of 57 @entity1 (5%) with nonshockable rhythm versus 28 of 66 (42%) with shockable rhythm had a favorable outcome (unadjusted odds ratio, 0.08; 95% CI, 0.02-0.3; adjusted odds ratio, 0.1; 95% CI, 0.03-0.4). At follow-up, 4 of 55 @entity1 (7%) versus 29 of 60 (48%) with nonshockable rhythm and shockable rhythm, respectively, had a favorable Cerebral Performance Category (odds ratio, 0.08; 95% CI, 0.03-0.3; adjusted odds ratio, 0.09; 95% CI, 0.09-0.3). Among those surviving hospitalization, favorable neurologic outcome was more likely at long-term follow-up than at hospital discharge for both groups (odds ratio, 2.5; 95% CI, 1.3-4.7; adjusted odds ratio, 2.9; 95% CI, 1.4-6.2). No significant interaction between changes in neurologic status over time and presenting rhythm was seen (p = 0.93). CONCLUSIONS: These data indicate an association between initial nonshockable rhythm and significantly worse short- and long-term outcomes in @entity1 treated with mild @entity2332 . Among survivors, neurologic status significantly improved over time for all @entity1 and shockable rhythm @entity1 and tended to improve over time for the small number of nonshockable rhythm @entity1 who survived beyond hospitalization. No significant interaction between changes in neurologic status over time and presenting rhythm was seen.

title: Impact of presenting rhythm on short- and long-term neurologic outcome in comatose survivors of XXXX treated with @entity2332 *.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['therapeutic hypothermia']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest', 'comatose survivors of out-of-hospital cardiac arrest']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: In @entity5 , epigenetic states are deregulated and thought to be of significance in @entity5 development and progression. We explored DNA methylation-based signatures in association with @entity0 subtypes to assess their impact on clinical presentation and @entity1 prognosis. DNA methylation was analyzed using Infinium 450K arrays in 40 @entity5 and 17 normal breast samples, together with DNA copy number changes and subtype-specific markers by tissue microarrays. The identified methylation signatures were validated against a cohort of 212 @entity5 annotated for @entity0 subtypes by the PAM50 method (The @entity5 ). Selected markers were pyrosequenced in an independent validation cohort of 310 @entity5 and analyzed with respect to survival, clinical stage and grade. The results demonstrate that DNA methylation patterns linked to the luminal-B subtype are characterized by CpG island promoter methylation events. In contrast, a large fraction of basal-like @entity5 are characterized by hypomethylation events occurring within the gene body. Based on these hallmark signatures, we defined two DNA methylation-based subtypes, Epi-LumB and Epi-Basal, and show that they are associated with unfavorable clinical parameters and reduced survival. Our data show that distinct mechanisms leading to changes in CpG methylation states are operative in different @entity0 subtypes. Importantly, we show that a few selected proxy markers can be used to detect the distinct DNA methylation-based subtypes thereby providing valuable information on disease prognosis.

title: A DNA methylation-based definition of biologically distinct XXXX subtypes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer Genome Atlas', 'cancer', 'tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVES: There is growing evidence of ongoing, in utero @entity16 in fetuses with myelomeningocele (MMC). Phospholipase A2 (PLA2) has known @entity2359 properties and is predominantly present in its secretory isoform ( @entity25191 ) in meconium, the passage of which is increased in MMC fetuses. The objective of this study was to determine if @entity6703 ( @entity6703 ) levels of PLA2 are elevated in a @entity35 model of MMC. METHODS: Timed pregnant @entity35 were gavage fed 60 mg/kg/bodyweight @entity1968 (RA) in olive oil at embryonic day 10 (E10). Amniocentesis was performed at multiple gestational time points on MMC fetuses, RA-exposed fetuses without MMC, and control fetuses. @entity6703 PLA2 levels were analyzed by a fluorescent enzyme activity assay. PLA2 isoforms were determined by measuring activity in the presence of specific inhibitors. RESULTS: There was no difference in @entity6703 PLA2 activity between groups on E15. PLA2 activity was significantly increased in MMC fetuses on E17, E19, and E21 (P < 0.001). Secretory PLA2 primarily accounted for the overall greater activity. CONCLUSIONS: PLA2 levels are elevated in the @entity6703 of fetal @entity35 with MMC and may contribute to ongoing @entity130 . This pathway may be a useful drug target to limit ongoing damage and better preserve neurologic function.

title: Amniotic fluid levels of Phospholipase A2 in fetal @entity35 with @entity1968 induced myelomeningocele: the potential "second hit" in XXXX .

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['neural injury']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological damage']

entities_list: @entity6703 :: ('MESH:D004619', 'Disease') :: ['amniotic fluid', 'AF']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats', 'rats']

entities_list: @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxic']

answer: @entity16 :: (MESH:D009422,Disease) :: ['neurologic damage']