abstract: The use of @entity1 umbilical cord (UC) blood as a source of transplantable hematopoietic stem cells and progenitor cells may present some advantages over the use of BM. For example, it has been suggested that the degree of HLA matching may be less stringent, and the risk of GvHD may be lower. We have been studying the ex vivo expansion of UC blood T lymphocytes with a view to their use in the adoptive immunotherapy of @entity5 , @entity792 , and @entity166 . We have developed a new method involving the use of a conditioned medium ( @entity34195 ) that consistently results in levels of UC blood T cell expansion not hitherto possible. Primary cultures of unfractionated low-density MNC (LDMNC) derived from UC blood treated with 5% @entity34195 routinely show expansions greater than 10,000-fold within 4 weeks. By contrast, similar @entity4434 -free cultures treated with @entity1199 expand less than 10-fold and not after 1 week, and cultures treated with @entity1199 and concanavalin A (ConA) expand to a maximum of only 300-500-fold over 2 weeks and fail to continue to proliferate thereafter. The MAb, OKT3, which, when combined with @entity1199 and @entity4434 , is known to stimulate proliferation of adult peripheral blood lymphocytes, permitted only a 17-fold expansion of UC blood lymphocytes under the same conditions. Thus, @entity34195 , which can also stimulate adult peripheral blood lymphocyte expansion to levels exceeding 100,000-fold in 3-4 weeks, is uniquely able to stimulate proliferation of UC blood lymphocytes to high levels. From initiation of the UC blood or adult peripheral blood LDMNC/ @entity34195 cultures up to approximately 2 weeks, the cultures are dominated by @entity404 + T lymphocytes. By 4 weeks, >80% of the cultured cells bear the @entity405 + phenotype, whereas UC blood T lymphocytes cultured in the presence of @entity1199 are predominantly @entity405 +. Thus, @entity34195 not only allows high levels of expansion of UC blood T lymphocytes not heretofore possible but also permits the selective expansion of different T lymphocyte subsets from a single source.

title: Large ex vivo expansion of @entity1 umbilical cord blood XXXX + and @entity405 + T cells.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmunity']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

answer: @entity404 :: (920,Gene) :: ['CD4']


abstract: In order to evaluate more objective laboratory methods that may help practicing pathologists to discern @entity5 in @entity1 @entity1636 , we have examined cellular DNA content by flow cytometry and immunohistochemical distribution of @entity517 , @entity2277 , @entity1364 ( @entity1364 ), and @entity470 ( @entity470 ) in 15 cases of @entity1 @entity1636 (nine @entity189 and six @entity652 ). All of these examinations were performed on routinely processed surgical pathology specimens. All @entity189 cases met Weiss's histologic criteria. Seven of eight @entity1636 demonstrated @entity2007 DNA content, while all @entity652 were diploid by flow cytometry. @entity517 oncoprotein was observed both in cytoplasms and nuclei in all @entity189 but only in nuclei in @entity652 . @entity2277 was present in all @entity189 cases examined but was also observed in three of six cases of @entity652 . There were no clinical or histologic differences between @entity2277 -positive and @entity2277 -negative @entity652 . Immunoreactivity of @entity1364 and @entity470 was observed in all the cases examined. There were no significant differences in distribution or patterns of immunoreactivity between @entity1636 and @entity652 . Therefore, we conclude that only DNA ploidy examined by flow cytometry and immunolocalization patterns of @entity517 oncoprotein expression have any practical value in the pathologic evaluation of @entity1636 . Careful morphologic and/or clinical studies are still considered to be the best available methods in discerning @entity5 in resected @entity1 @entity1636 .

title: @entity5 in XXXX @entity1636 : utility of DNA flow cytometry and immunohistochemistry.

entities_list: @entity1364 :: ('5111', 'Gene') :: ['proliferating cell nuclear antigen', 'PCNA']

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploid']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity470 :: ('1956', 'Gene') :: ['EGFR', 'epidermal growth factor receptor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma']

entities_list: @entity1636 :: ('MESH:D018268', 'Disease') :: ['adrenocortical carcinomas', 'adrenocortical neoplasms', 'adrenocortical carcinoma']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: The prevalence of @entity6069 ) mutations in germline DNA from unselected @entity43 @entity1 is 11% to 15.3%. It is important to determine the frequency of somatic @entity6069 ) changes, given the sensitivity of BRCA-mutated @entity5 to @entity12874 polymerase-1 ( @entity12982 ) inhibitors and @entity902 analogs. @entity1 AND METHODS: In 235 unselected @entity43 , @entity6069 ) was sequenced in 235, assessed by copy number analysis in 95, and tiling arrays in 65. 113 @entity5 were sequenced for @entity876 . @entity6069 ) transcript levels were assessed by quantitative polymerase chain reaction in 220. When available for @entity5 with @entity6069 ) mutations, germline DNA was sequenced. RESULTS: Forty-four mutations (19%) in @entity5345 (n = 31)/ @entity2674 (n = 13) were detected, including one homozygous @entity5345 intragenic deletion. @entity6069 ) mutations were particularly common (23%) in high-grade serous @entity5 . In 28 @entity1 with available germline DNA, nine (42.9%) of 21 and two (28.6%) of seven @entity5345 and @entity2674 mutations were demonstrated to be somatic, respectively. Five mutations not previously identified in germline DNA were more commonly somatic than germline (four of 11 v one of 17; P = .062). There was a positive association between @entity5345 and @entity876 mutations (P = .012). @entity6069 ) mutations were associated with improved progression-free survival (PFS) after @entity902 -based chemotherapy in univariate (P = .032; hazard ratio [HR] = 0.65; 95% CI, 0.43 to 0.98) and multivariate (P = .019) analyses. @entity6069 ) deficiency, defined as @entity6069 ) mutations or expression loss (in 24 [13.3%] @entity6069 )-wild-type @entity5 ), was present in 67 @entity43 (30%) and was also significantly associated with PFS in univariate (P = .026; HR = 0.67; 95% CI, 0.47 to 0.96) and multivariate (P = .008) analyses. CONCLUSION: @entity6069 ) somatic and germline mutations and expression loss are sufficiently common in @entity43 to warrant assessment for prediction of benefit in clinical trials of @entity12982 inhibitors.

title: Somatic mutations in @entity5345 and @entity2674 could expand the number of @entity1 that benefit from poly (ADP ribose) polymerase inhibitors in XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancers', 'ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity12874 :: ('MESH:D011064', 'Chemical') :: ['poly (ADP ribose)']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'tumors']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: OBJECTIVE: To investigate the value of @entity8984 fluorodeoxyglucose-positron emission tomography/computed tomography ((18)F FDG-PET-CT) in the diagnosis and the evaluation of disease activity and remission of @entity6017 ( @entity3918 ). METHODS: @entity3918 @entity1 who were admitted to the Department of Rheumatology, the @entity1 's Liberation Army General Hospital (PLAGH) and underwent @entity8984 FDG-PET-CT examination were retrospectively reviewed from January 2012 to May 2015.Gender and age matched healthy controls (HC) were also enrolled.The standardized uptake value (SUV) of proximal limb girdle muscles in both groups were recorded and compared, so as between @entity1 with @entity3918 or subclinical @entity3918 .The correlation between myodynamia of proximal limb girdle muscle, @entity908 kinase(CK), CK-MB, serum ferritin and SUV of each muscle group were analyzed. RESULTS: There were 58 @entity1 with @entity3918 and 29 controls consecutively recruited in the study.The SUV of upper arms (1.814  0.830) g/ml, shoulders (2.134  0.797) g/ml and hips (1.883  0.683) g/ml in @entity1 with classic @entity3918 were significantly higher than those with subclinical @entity3918 [(0.938  0.218) g/ml, (1.152  0.315) g/ml, (0.945  0.249) g/ml; P<0.05]. SUV of muscles in newly diagnosed @entity1 was (1.051  0.031) g/ml, which was higher than that in subclinical @entity1 .But the difference was not statistically significant (P>0.05). The average SUV of evaluated muscles in @entity3918 group (2.033  0.858) g/ml was significantly higher than that in controls (1.076  0.167) g/ml (P<0.001). Receiver operating characteristic(ROC) analysis revealed the area under the curve(AUC) of abnormal SUV detected by @entity8984 FDG-PET-CT for diagnosing @entity3918 was 0.953.The myodynamia of upper arms and SUV was negatively correlated (rs=-0.440, P=0.031). However, the level of serum @entity908 kinase and SUV was positively correlated (rs=0.500, P=0.013). The average SUV of @entity1 whose time to remission was less than 3 months (1.746  0.466) g/ml was obviously less than that of @entity1 with 3 to 6 months to obtain remission (2.815  0.848) g/ml (P=0.015). CONCLUSIONS: The SUV of proximal limb girdle muscles detected by @entity8984 FDG-PET-CT has a positive diagnostic value for @entity3918 .Moreover, the SUV in upper arms is correlated with the muscle strength and the level of @entity908 kinase, which reflect disease activity. @entity8984 FDG-PET-CT might be an alternative method to evaluate the response of treatment.

title: [The application of XXXX fluorodeoxyglucose-positron emission tomography/computed tomography in the diagnosis and treatment of @entity6017 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'People']

entities_list: @entity6017 :: ('MESH:D003882', 'Disease') :: ['dermatomyositis']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

answer: @entity8984 :: (CHEBI:36939,Chemical) :: ['(18)F']


abstract: BACKGROUND: Epidemiological data suggests for every 1% reduction in LDL-C there is a corresponding 1-1.5% reduction in cardiovascular events (CVEs). Additionally, for every 2-3% increase in HDL-C there is a reduction in CVEs by 2-4% that is independent of LDL-C. With numerous treatment options for managing @entity2299 , it is important to evaluate agents that result in the greatest reduction of CVEs. OBJECTIVE: To compare current high-potency @entity2299 pharmacotherapy with respect to changes in LDL-C and HDL-C and estimate risk reductions for CVEs. METHODS: This study is an analysis of existing published studies for @entity2299 products marketed in the US. Literature searches were conducted using Medline, International Pharmaceutical Abstracts, Embase, and CINAH to identify trials for @entity1670 extended-release and lovastatin (NER/L); @entity1670 extended-release and @entity3413 (NER/S); @entity8671 (R); and, @entity3709 / @entity3413 (E/S) from database inception to 1 May 2009. Demographics and changes from baseline in LDL-C and HDL-C were abstracted and HDL-C to LDL-C change (%Delta-lipids) was created for each therapy. Using a previously validated model the percent reduction in CVEs was estimated for each treatment strategy. RESULTS: Data for 177 treatment arms (120 unique reports), accounting for drug and dose were abstracted. The range in mean +/- SD %Delta-lipids depending on drug dose was: E/S, 58 +/- 6 to 67 +/- 3; R, 51 +/- 5 to 65 +/- 5; NER/L, 33 +/- 7 to 75 +/- 7; and NER/S, 48 to 77 +/- 4. Risk reductions were greatest for NER/statin combinations, with percent risk reductions greater than 77% for NER/S, 2000 mg/10 mg and 83% NER/S, 2000 mg/40 mg. Ignoring medication strengths, reductions in CVEs ranged from 58% for R, 60% for E/S, 61% for NER/L, and 72% for NER/S. LIMITATIONS: There are several potential limitations associated with this study including: publication bias, English only search, limited published studies with NER in combination with L or S, adherent populations, and aggregation of multiple populations. CONCLUSION: The results of the analysis suggest that greater risk reductions in CVEs occur with combination therapies, especially those including @entity1670 extended-release (NER). Up to an 83% risk reduction was estimated for the highest doses of @entity31501 and @entity3413 (NER/S).

title: Prediction of cardiovascular event risk reduction from lipid changes associated with high potency XXXX therapy.

entities_list: @entity3413 :: ('MESH:D019821', 'Chemical') :: ['simvastatin']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin']

entities_list: @entity3709 :: ('MESH:C108606', 'Chemical') :: ['ezetimibe']

answer: @entity2299 :: (MESH:D050171,Disease) :: ['dyslipidemia']


abstract: We isolated three cDNA clones (pSGJ1, pSGJ2 and pSGJ3) for DnaJ-like proteins of the Japanese willow (Salix gilgiana Seemen). The insert in pSGJ2 included the entire @entity377 sequence of the insert in pSGJ1 that was separated into four parts by three intron-like sequences, and it might correspond to the cDNA for a precursor to the SGJ1 mRNA. The predicted @entity535 sequences of SGJ1 (47.5 kDa) and SGJ3 (46.6 kDa) exhibited about 70 to 91% homology to plant cytoplasmic DnaJ-like proteins. SGJ1 was encoded by one or a few genes within the willow genome while SGJ3 was encoded by several genes. Expression of the SGJ1 and SGJ3 genes was compared with that of @entity2285 ( @entity15188 ) gene. Constitutive expression of SGJ1, SGJ3 and @entity15188 was detected in all organs examined. The SGJ1 mRNA was most abundant in male catkins (inflorescences). High-level expression of SGJ3 and @entity15188 was detected in catkins and roots of both male and female plants. The level of the SGJ3 mRNA in the leaves increased about 10-fold after 1 h of heat stress while the expression of SGJ1 mRNA reached a maximum level after 6 h. However, the extent of induction of SGJ1 mRNA was quite low. The levels of SGJ1 and SGJ3 mRNAs in the leaves increased about 6-fold and 2-fold, respectively, after 24 h of treatment with 100 mM @entity1219 . Thus, the SGJ1 and SGJ3 genes showed differential expression patterns in a variety of organs and in response to different environmental conditions.

title: Expression of DnaJ homologs and XXXX in the Japanese willow (Salix gilgiana Seemen).

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

answer: @entity2285 :: (3308,Gene) :: ['Hsp70']


abstract: In the World Health Organization classification, @entity2220 with @entity325 is defined as @entity189 with evidence of vascular, pleural, or stromal invasion. The histological criteria for stromal invasion, however, are not clearly established. A total of 157 peripheral pure @entity133 ( @entity133 ) or @entity2220 with mixed @entity133 and others were reviewed. All cases had been resected between 1986 and 2000 and measured < or =30 mm in maximum dimension. @entity133 ( @entity133 ) was defined as distortion or discontinuity of the alveolar framework by @entity5 growth. The extra-alveolar area involvement (EAAI) was defined as @entity5 growth outside the alveolar framework, which includes the following areas: bronchial wall, perivascular connective tissue and/or the vascular wall, interlobular septum and the visceral pleura. Survival of @entity1 with @entity420 without @entity133 (n = 41) was 100%. Even when @entity420 involved @entity133 and lacked EAAI (n = 21), survival was 100%. The 5 year survival rate of groups with two invasion signs (n = 34) was 90.1%, and that of groups with three to five invasion signs (n = 61) was 66.7%. @entity5 growth outside the alveolar framework is the hallmark of stromal invasion.

title: Clinicopathology of stromal invasion in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma']

entities_list: @entity133 :: ('MESH:D002282', 'Disease') :: ['DAF', 'bronchioloalveolar carcinoma', 'Destruction of alveolar framework', 'BAC']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['mixed subtypes']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

answer: @entity2220 :: (MESH:C538231,Disease) :: ['lung adenocarcinoma']


abstract: BACKGROUND: We compared relative survival rates of @entity1 after various operative treatments for @entity1028 ( @entity1028 ) to those for the general population. We calculated a point of "recovery," defined as the survival rate equal to that of the general population. METHODS: Survival data were collected from @entity1 who underwent open repair for a @entity397 ( @entity1755 ), elective open repair of an @entity1028 ( @entity16008 ), and endovascular repair (EVAR) in our hospital between 1995 and 2005. The cumulative relative survival rate and time-specific relative survival rate were calculated for these @entity1 compared to those for the general population. The point of "recovery" was defined as the cumulative relative survival rate equaling the survival rate for the population, and the time-specific relative survival rate reaching 1.0. RESULTS: The cumulative relative survival rate of the @entity1 immediately after @entity16008 was lower than for the comparison group at the time the cumulative relative survival rate was regained. The time-specific relative survival rate of the @entity1755 reached 1.0 at 16  months following emergency surgery, and for @entity16008 after 10  months. The cumulative relative survival rate in the EVAR group had no impairment following intervention. The relative long-term survival rate in all three surgical groups was the same as that for the general German population. CONCLUSIONS: @entity1 treated successfully for @entity1028 have the same relative long-term survival as the general population. The time required to reach the same survival, however, differs between the treatment groups and is longest in the group with a @entity1755 . The variable survival rates should be taken into consideration when treating @entity1 with an @entity1028 .

title: Comparison of survival rates for XXXX treatment methods.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured AAA']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: This study assessed the validity and test-retest reliability of a medical and occupational history questionnaire for workers performing welding in the shipyard industry. This self-report questionnaire was developed for an epidemiologic study of the risk of @entity304 in welders. Validity @entity1 recruited from three similar shipyards were asked to give consent for access to personnel files and complete the questionnaire. Responses on the questionnaire were compared with information extracted from personnel records. Reliability @entity1 were recruited from the same shipyards and were asked to complete the questionnaire at two different times approximately 4 weeks apart. Percent agreement, kappa, intraclass correlation coefficient (ICC), and sensitivity and specificity were used as measures of validity and/or reliability. Personnel files were obtained for 101 of 143 @entity1 (70%) in the validity study, and 56 of the 95 (58.9%) @entity1 in the reliability study completed the retest of the questionnaire. Validity scores for items extracted from personnel files were high. Percent agreement for employment dates and job titles ranged from 83-100%, while ICC for start and stop dates ranged from 0.93-0.99. Sensitivity and specificity for current job title ranged from 0.5-1.0. Reliability scores for demographic, medical and health behavior items were mainly moderate or high, but ranged from 0.19 to 1.0. Most recent job/title items such as title, types of welding performed, and material used showed substantial to perfect agreement. Certain determinants of exposure such as days and hours per week exposed to welding fumes demonstrated mainly moderate agreement (kappa= 0.42-0.47, percent agreement 63-77%); however, mean days and hours reported did not differ between test and retest. The results of this study suggest that @entity1 ' self-report for job title and dates employed are valid compared with employer records. While kappa scores were low for some medical conditions and for @entity5834 consumption, high kappa scores for job title, dates worked, types of welding, and materials welded suggest @entity1 generated reproducible answers important for occupational exposure assessment.

title: Validity and reliability of an occupational exposure questionnaire for XXXX in welders.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['parkinsonism']

answer: @entity304 :: (MESH:D010302,Disease) :: ['parkinsonism']


abstract: OBJECTIVES/HYPOTHESIS: The study group for sinonasal @entity5 at the Korean Rhinologic Society analyzed the results of the Korean multicenter experience for sinonasal @entity1179 ( @entity1179 ) surgeries. STUDY DESIGN: Multicenter cohort study and retrospective analysis. METHODS: In total, 939 @entity1 diagnosed with sinonasal @entity1179 treated between 1998 and 2007 at 17 university hospitals were enrolled. Demographic data and information about previous surgeries, the origin and involved site of the @entity5 , the surgical approach, follow-up duration, recurrence, and the presence of @entity5 were collected. There were 361 @entity1 whose follow-up was <12 months who were excluded, and 578 @entity1 were included for recurrence analysis. RESULTS: The mean follow-up duration for recurrence analysis was 41.0 months, and 15.7% (91/578) had recurrences, with a mean time to recurrence of 32.6 months. However, the group whose follow-up was longer than 3 years had a higher chance of @entity5 recurrence. @entity1 whose IPs involved the frontal sinus or the medial wall of the maxillary sinus had higher recurrence rates. There was no significant difference in recurrence rates according to stage or surgical approach. In the T3 stage of Krouse, the T3-A stage of Furuta, and group B of the Citardi staging system, the endoscopic approach alone resulted in higher recurrence rates. CONCLUSIONS: Generally, there were no significant differences in recurrence rates according to clinical stage or surgical approach. Given the rate of delayed recurrence, follow-up of >3 years is required. Moreover, surgeons should always consider combined approaches to reduce the chances of recurrence.

title: XXXX of the nasal cavity and paranasal sinuses: a Korean multicenter study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy', 'tumors']

entities_list: @entity1179 :: ('MESH:D018308', 'Disease') :: ['IP', 'inverted papilloma']

answer: @entity1179 :: (MESH:D018308,Disease) :: ['Inverted papilloma']


abstract: Despite improvements in the quality of @entity5383 ceramics, @entity3061 has been reported anecdotally after total hip arthroplasty (THA) with use of a contemporary @entity5383 -on- @entity5383 ceramic bearing. The purpose of this study was to evaluate the clinical and radiographic outcomes of @entity2445 using @entity5383 -on- @entity5383 ceramic bearing and to determine @entity3061 using radiographs and computed tomographic (CT) scans in young @entity1 . Consecutive primary cementless THA using @entity5383 -on- @entity5383 ceramic bearing were performed in 64 @entity1 (93 hips) who were younger than 45 years of age with @entity2738 . There were 55 @entity1 (84 hips) and nine @entity1 (nine hips). Average age was 38.2 (range 24-45) years. Average follow-up was 11.1 (range 10-13) years. Preoperative Harris Hip Score was 52.9 (range 22-58) points, which improved to 96 (range 85-100) points at the final follow-up examination. Two of 93 hips (2%) had clicking or squeaking sound. No hip had revision or @entity1349 . Radiographs and CT scans demonstrated that no acetabular or femoral @entity3061 was detected in any hip at the latest follow-up. Contemporary cementless acetabular and femoral components with @entity5383 -on- @entity5383 ceramic bearing couples function well with no @entity3061 at a ten year minimum and average of 11.1-year follow-up in this series of young @entity1 with @entity2738 .

title: Cementless total hip arthroplasty with ceramic-on-ceramic bearing in XXXX younger than 45 years with @entity2738 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity3061 :: ('MESH:D010014', 'Disease') :: ['osteolysis']

entities_list: @entity2738 :: ('MESH:D005271', 'Disease') :: ['femoral-head osteonecrosis']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['aseptic loosening']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The average therapeutic effect of classical tricyclic antidepressants and antidepressants of the second and third generation varies between 60-70%. Moreover, tricycklic antidepressants are associated with undesirable effects mostly anticholinergic and " @entity1370 ", which may be a contraindication in particular in @entity1 with @entity66 and in older age groups. The authors compared two new alternative therapeutic procedures, represented by new highly effective @entity1245 and anticonvulsants, as regards the therapeutic effect and side-effects. From this comparison ensues that their general therapeutic effect is on average comparable with the effect of tricyclic antidepressants, however, in the spectrum of their undesirable symptoms the anticholinergic effects are absent. Recent @entity1245 have a better effect on @entity308 where @entity148 and @entity2146 are in the foreground. Their effect on depressive core symptoms is more marked, as compared with anticonvulsants. The most frequent side-effects are fatigue, @entity2147 and vertigo. Anticonvulsants have a balanced effect in different @entity308 . Undesirable effects are mostly gastrointestinal. In the authors' trials it did not lead to hypomania.

title: [Alternative therapy in the acute phase of endogenous depression--antiepileptics and new XXXX and their comparison].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['syndromological forms of depression', 'depressions']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['multiple diseases']

entities_list: @entity2147 :: ('MESH:D006970', 'Disease') :: ['somnolence']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxic']

answer: @entity1245 :: (MESH:D001569,Chemical) :: ['benzodiazepines']


abstract: Alongside the physical symptoms associated with @entity191 @entity303 and @entity303 with @entity1832 , health services must also address the @entity73 that accompany these conditions. There is growing interest in the use of nonpharmacological approaches to managing the consequences of @entity73 . Cognitive rehabilitation is a goal-orientated behavioural intervention which aims to enhance functional independence through the use of strategies specific to the individual's needs and abilities. Fundamental to this therapy is a @entity1 's capacity to set goals for rehabilitation. To date, no studies have assessed goal setting in early-stage @entity191 @entity303 or @entity303 with @entity1832 . Semistructured interviews were carried out with 29 @entity1 from an ongoing trial of cognitive rehabilitation for @entity1 with these conditions. Here, we examined the goal statements provided by these @entity1 using qualitative content analysis, exploring the types and nature of the goals set. @entity1 ' goals reflected their motivations to learn new skills or improve performance in areas such as technology-use, self-management and orientation, medication management, and social and leisure activities. These results suggest that goal setting is achievable for these @entity1 , provide insight into the everyday cognitive difficulties that they experience, and highlight possible domains as targets for intervention. The trial is registered with ISRCTN16584442 (DOI 10.1186/ISRCTN16584442 13/04/2015).

title: Goal Setting for Cognitive Rehabilitation in Mild to Moderate @entity191 XXXX and @entity303 with Lewy Bodies.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'person', 'people']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive disorder', 'cognitive impairments']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

entities_list: @entity1832 :: ('MESH:D020961', 'Disease') :: ['Lewy bodies']

answer: @entity303 :: (MESH:D003704,Disease) :: ['Dementia']


abstract: OBJECTIVE: To investigate the reinfection rate of @entity1534 ( @entity1534 ) in gastric mucosa by two measures of oral plaque control on @entity1 , and to demonstrate the necessity and better method of plaque control on those @entity1 . METHODS: 148 @entity1 suffered @entity3621 or gastroduodenal ulcer were assigned into test group 1 (54 @entity1 ), test group 2 (55 @entity1 ) and control group (39 @entity1 ). @entity19018 breath test proved that there were no @entity1534 in their gastric mucosa. Daily plaque control was used in test group 1, oral professorial interventions were added into test group 2, neither daily plaque control nor oral professorial interventions was conducted in control group. All @entity1 were conducted @entity19018 breath test again after half a year to determine the reinfection rate of @entity1534 in gastric mucosa. RESULTS: 5 @entity1 were eliminated because of stopping mouthwash in the test group 1, 8 @entity1 failed to control dental plaque in the test group 2. The infection rates of @entity1534 in gastric mucosa of test group 1, test group 2 and control group were 67.3%, 19.1%, 82.1%, respectively. The infection rate of @entity1534 of test group 2 was lower significantly than that in control group and test group 1 (chi2=33, P<0.05; chi2=31.06, P<0.05). There were no significant difference between test group 1 and control group (chi2=2.43, 0.1<P<0.25). CONCLUSION: @entity2413 is an important source of gastric @entity1534 reinfection. @entity2413 control procedures should be performed in the treatment of @entity1819 correlated with @entity1534 . The method of mixing professional dental plaque control and solution of mouthwash was better.

title: [Effects on XXXX reinfection in gastric mucosa by two oral plaque control methods].

entities_list: @entity2413 :: ('MESH:D003773', 'Disease') :: ['Dental plaque']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric disease']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity1534 :: ('210', 'Species') :: ['H. pylori', 'Helicobacter pylori']

answer: @entity1534 :: (210,Species) :: ['Helicobacter pylori']


abstract: OBJECTIVE: To evaluate weight change during @entity1378 treatment, and to correlate it with @entity650 and @entity310 concentrations. SUBJECTS AND METHODS: Forty two @entity1 were included. Body weight (BW), body mass index (BMI), clinical and laboratory characteristics were recorded. @entity650 and @entity310 were determined before treatment with @entity3937 ( @entity3936 ) and in @entity3214 . RESULTS: BW was 59.62    11.5 kg in @entity1378 , and 69.91    14.4 kg in @entity3214 (p < 0.001). BMI increased from 23.1    3.8 kg/m(2) to 27 kg/m(2)    4.7 during treatment (p < 0.0001). Before treatment, 66.6% subjects had BMI < 25 kg/m(2) and 33.3%, BMI > 25 kg/m(2). In @entity3214 , 38% of @entity1 had BMI < 25 kg/m(2) and 62%, BMI > 25 kg/m(2) (p = 0.01). In @entity3214 , we found a significant reduction in @entity650 and @entity310 concentrations, but no correlation between @entity650 and @entity310 , and BW or BMI. CONCLUSION: An important increase in BW and BMI was observed during @entity1378 treatment, and @entity650 and @entity310 alterations were only related with @entity3214 .

title: [Evaluation of body weight in XXXX with Graves' disease during the treatment with @entity3937 ].

entities_list: @entity3937 :: ('MESH:D008713', 'Chemical') :: ['methimazole']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism']

entities_list: @entity3214 :: ('MESH:D005067', 'Disease') :: ['return to euthyroidism', 'euthyroidism']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: To compare clinically and histologically an allogeneic bone matrix to autogenous bone chips in the vertical ridge augmentation technique using @entity702 -reinforced e-PTFE membranes. MATERIALS AND METHODS: The study protocol was designed to include @entity1 with bilateral posterior mandibular partial @entity5386 . @entity1 were treated with a split-mouth design approach: each side was randomly assigned to the test group ( @entity702 -reinforced e-PTFE membrane and allogeneic bone matrix) or to the control group ( @entity702 -reinforced e-PTFE membrane and autogenous bone chips). Different clinical parameters including the amount of vertically regenerated bone (DSB) and biologic complications were recorded. Histomorphometric analysis and the bone-implant contact percentage were performed. RESULTS: Five female @entity1 were enrolled in the study. Ten edentulous sites were vertically augmented and 25 implants were inserted (13 test group, 12 control group) with a staged approach. In the test group no membrane was exposed. The mean bone regeneration was 4.70 mm (SD 0.48 mm). All 13 implants appeared clinically stable. In the control group, 1 membrane was exposed after 2 months. The mean crestal bone regeneration was 4.10 mm (SD 0.88 mm). All 12 implants were stable at the abutment connection. Nine biopsy specimens from the regenerated areas were evaluated. Vertical bone regeneration was evident in both groups since all the samples demonstrated trabecular bone with different degrees of maturation and mineralization in the regenerated area. CONCLUSION: Within the limits of this study based on 5 @entity1 , it appears that the behavior of the allogeneic bone matrix is similar to that of autogenous bone chips when used for vertical ridge augmentation by means of guided bone regeneration techniques. Both grafts demonstrated analogous histologic characteristics. Nevertheless, long-term clinical studies are needed to confirm these preliminary results.

title: Clinical and histologic evaluation of allogeneic bone matrix versus autogenous bone chips associated with XXXX -reinforced e-PTFE membrane for vertical ridge augmentation: a prospective pilot study.

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity5386 :: ('MESH:D007575', 'Disease') :: ['edentulism']

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: The role of white blood cells in acute @entity6220 , such as @entity64 or @entity130 is poorly understood. In this experimental study the effect of @entity1398 on posttraumatic @entity4 was investigated. Polyclonal antiserum against polymorphonuclear leukocytes was used to induce @entity1398 . Control animals received normal serum or no treatment at all. @entity4 and brain water content after cryo-injury to the exposed left cerebral hemisphere was gravimetrically assessed, and by the wet weight-dry weight method. Administration of anti-neutrophil serum led to a significant reduction of circulating neutrophils. In untreated animals or in @entity35 receiving normal serum, hemispheric swelling of the brain was 7.26 +/- 0.35% or 8.52 +/- 0.26%, respectively. @entity1398 induced by anti-neutrophil serum resulted in a significant increase in hemispheric swelling to 11.44 +/- 0.84% (p less than 0.001). It may be noted, however, that the enhancement of @entity4 by @entity1398 was not obvious when comparing the water contents of the affected hemispheres of animals subjected to @entity130 with and without anti-neutrophil serum. The enhancement of @entity4 by @entity1398 suggests a protective function of neutrophils against extravasation in the presence of a broken blood-brain barrier.

title: Effects of antineutrophil serum (ANS) on posttraumatic @entity4 in XXXX .

entities_list: @entity6220 :: ('MESH:D020279', 'Disease') :: ['central nervous system disorders']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['brain oedema', 'brain swelling', 'Hemispheric swelling']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['Neutropenia', 'neutropenia']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['cold injury', 'traumatic injury']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: INTRODUCTION: Skeletal muscle wasting and weakness with @entity2383 ( @entity2383 ) are major pathological problems in @entity130 ( @entity130 ) @entity1 . @entity2002 levels elevated in plasma is an accepted risk factor for poor prognosis in many @entity1 diseases, and is also designated one of damage-associated molecular pattern (DAMPs) proteins. The roles of upregulated @entity2002 on muscle changes of @entity3124 including @entity130 are unknown. The hypothesis tested was that @entity130 -upregulated @entity2002 plays a pivotal role in the inflammatory responses and @entity2383 in muscles, and that DAMPs inhibitor, @entity11950 mitigates the muscle changes. METHODS: After third degree @entity130 to @entity19 , @entity2002 levels in the plasma and at skeletal muscles were compared between @entity130 and sham-burn (SB) @entity19 . @entity2002 effects on inflammatory responses and mitochondrial membrane potential (MMP) loss were analyzed in C2C12 myotubes. In addition to survival, the anti-inflammatory and mitochondrial protective effects of @entity11950 were tested using in vivo microscopy of skeletal muscles of @entity130 and SB @entity19 . RESULTS: @entity2002 in plasma and its extravasation to muscles significantly increased in @entity130 versus SB @entity19 . @entity2002 applied to myotubes evoked inflammatory responses (increased @entity8929 and @entity637 ; 32.6 and 3.9-fold, respectively) and reduced MMP; these changes were ameliorated by @entity11950 treatment. In vivo MMP loss and @entity224 production in skeletal muscles of @entity130 @entity19 were significantly attenuated by @entity11950 treatment, together with improvement of @entity130 survival rate. CONCLUSIONS: Inflammatory responses and MMP loss in myotubes induced by @entity2002 were reversed by @entity11950 . Anti-inflammatory and mitochondrial protective effect of @entity11950 in vivo leads to amelioration of @entity121 and improvement of @entity130 survival rate.

title: Role of Elevated XXXX in Burn-Induced Mitochondrial Dysfunction: Protective Effects of @entity11950 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity2002 :: ('2244', 'Gene') :: ['Fibrinogen', 'fibrinogen']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle MD']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness']

entities_list: @entity11950 :: ('MESH:D019695', 'Chemical') :: ['glycyrrhizin']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['BI', 'burn injury']

entities_list: @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction', 'MD']

answer: @entity2002 :: (2244,Gene) :: ['Fibrinogen']


abstract: The etiology of @entity1373 is obscure. We believe that it is due more likely to an intra-uterine influence rather than to genetic disturbances. The disorder appears to have its basis in the cartilagenous growth centre of the mandibular condyle. The clinical picture varies a great deal, depending upon the onset of the growth upset relative to the age of the @entity1 and the rate of growth. Two cases are reported. In one @entity1 the anomalous growth pattern was apparent particularly in the condylar neck, which showed marked elongation, thickening and angulation. In the other @entity1 the entire condyloid process appeared proportionately enlarged. The typical clinical history is one in which the @entity1 had been aware for many years of progressive deviation of the jaw. @entity158 in the T.M.J. regions is rarely the presenting symptom. With recent advances of oral surgery, restoration of @entity3232 and facial disharmony can be achieved by approaches other than the traditional procedure of condylectomy.

title: XXXX and the associated deformity of facial asymmetry. Case report.

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['unilateral condylar hyperplasia']

entities_list: @entity3232 :: ('MESH:D008310', 'Disease') :: ['malocclusion']

answer: @entity1373 :: (MESH:D006965,Disease) :: ['Unilateral condylar hyperplasia']


abstract: In an open, prospective, randomized, and hospital-based study, comprising 219 consecutive @entity1 , 169 were given intermittent prophylaxis for one year, receiving either @entity3175 or @entity1092 after their first febrile @entity410 . @entity1 admitted on odd dates (n = 89) were given rectal @entity3175 in solution every 12 h, whenever the temperature was 38.5 degrees C or more. @entity1 admitted on even dates (n = 80) were given @entity1092 as suppositories at times of fever. Twenty-three @entity1 in the @entity3175 group had a recurrence within 1 year versus 14 in the @entity1092 group. On an intention-to-treat basis the 12-month recurrence rates in the 2 groups were similar, 27% vs 20%. The latter is well below figures for untreated controls from Denmark (32%), suggesting that intermittent @entity1092 at times of fever may be effective, but further studies are needed. The number of complex recurrences, however, were significantly higher in the @entity1092 group than in the @entity3175 group. Parental non-compliance was a major problem, and in the 2 study groups only 5 and 12 @entity1 , respectively, with recurrences were treated adequately. Sixty-nine @entity1 receiving @entity3175 had side-effects vs 37 receiving @entity1092 . None were serious.

title: Intermittent prophylaxis in febrile XXXX : @entity3175 or @entity1092 ?

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid']

entities_list: @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsion']

answer: @entity410 :: (MESH:D012640,Disease) :: ['convulsions']


abstract: A 61-year-old @entity1 presented with drowsiness, @entity353 . On examination he had several splinter @entity548 and a tender mass over the right temporal region. Respiratory and abdominal examinations were unremarkable and heart sounds were normal with no clinically audible murmurs. He spiked regular temperatures and consequently had several blood cultures taken. Transthoracic and transoeseophageal echocardiogram showed a 3 cm mitral @entity340 . MRI confirmed suspicions of @entity999 in the brain. Blood cultures grew Rothia aeria and he was started on @entity3397 , @entity1215 and @entity801 . After a period of observation he deteriorated clinically and biochemically, surgical intervention therefore ensued with an urgent metallic mitral valve replacement. Nineteen days postsurgery the @entity1 was successfully discharged on outpatient antibiotic therapy and @entity1229 . In view of complications such as embolisation and @entity385 , R aeria @entity884 should be managed aggressively and with a high index of clinical suspicion.

title: The first report of survival post Rothia aeria XXXX .

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['decreased appetite and weight loss']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhages']

entities_list: @entity999 :: ('MESH:D020766', 'Disease') :: ['septic emboli']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['endocarditis']

entities_list: @entity3397 :: ('MESH:D010400', 'Chemical') :: ['benzylpenicillin']

entities_list: @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valve vegetation']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity884 :: (MESH:D004696,Disease) :: ['endocarditis']


abstract: PURPOSE: @entity10 and @entity490 are examples of minor ailments that are generally self-limiting. We examined the extent to which patterns of visits to family physicians for minor ailments, such as @entity10 or @entity490 , cluster within families. METHODS: Using information from the Second Dutch National Survey of General Practice for 96 family practices, we analyzed the visits of families with at least 1 @entity1 aged 12 years or younger during a period of 12 months. RESULTS: Family patterns were clearest in the visits of mothers and @entity1 . A large part of the similarity in the frequencies of contact by mothers and daughters could be attributed to shared family factors. This finding was especially true for families with a @entity1 who had a @entity10 or @entity490 as the presenting symptom, rather than physical @entity130 or @entity102 . Within families, we did not find any specific patterns of diagnoses. Diagnoses were recorded by family physicians. In the case of young @entity1 , family similarity may have been overestimated because parents initiated the visits and put their @entity1 's health problem into words. CONCLUSIONS: Visits to family physicians for @entity10 or @entity490 can be seen as indicators of consultation patterns in families. Family patterns related to minor ailments are likely to be a result of socialization. Family consultation patterns might point toward specific needs of families and consequently at a different approach to treatment.

title: All in the family: XXXX and @entity490 as indicators for consultation patterns in families.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headaches', 'headache', 'headaches']

answer: @entity10 :: (MESH:D006261,Disease) :: ['headaches']


abstract: There is immense variability in the clinical presentation of @entity2916 and many incomplete forms (formes frustes) exist. To investigate the imaging characteristics of cortical tubers seen in @entity2916 unaccompanied by other stigmata, we reviewed MRI and CT of six @entity1 who met the criteria for a definitive diagnosis of @entity1950 , established solely by the presence of a histologically confirmed cortical tuber. Five of the @entity1 had a solitary cortical tuber and the last had three lesions, one of which was resected and confirmed histologically. The other two lesions were included in our study. CT showed five tubers as low density, but three were not identified. No calcified or dense lesions were observed. MRI revealed peripheral components and inner cores of seven cortical tubers in five @entity1 , with differing signal characteristics. The subcortical cores, with T1 and T2 prolongation, were separated from the overlying cortex. Abnormal inhomogeneous high signal was observed in both the @entity62 on proton-density weighted or FLAIR images. A radially orientated white-matter band was observed in one @entity1 , and central @entity308 of the expanded gyri in another. In one @entity1 , a cortical tuber was atypical, with a thick cortex on T1-weighted images and a blurred grey/white matter junction with diffusely increased signal on T2-weighted images. Cortical tubers without other stigmata of @entity2916 are shown to be distinct from focal @entity6795 .

title: Cortical tubers without other stigmata of XXXX : imaging and pathological findings.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity6795 :: ('MESH:D054220', 'Disease') :: ['cortical dysplasia']

entities_list: @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['cortex and subcortical white matter']

answer: @entity2916 :: (MESH:D014402,Disease) :: ['tuberous sclerosis']


abstract: BACKGROUND: Health-related quality of life (QOL) is an important measure of how disease affects @entity1 ' lives. Dialysis @entity1 have decreased QOL relative to healthy controls. Little is known about QOL in @entity1 with @entity740 ( @entity740 ) before renal replacement therapy. METHODS: The Medical Outcomes Study Short Form-36 (SF-36), a standard QOL instrument, was used to evaluate 634 @entity1 (mean glomerular filtration rate [GFR], 23.6 +/- 9.6 mL/min/1.73 m2 [0.39 +/- 0.16 mL/s/1.73 m2]) enrolled in a 4-center, prospective, observational study of @entity740 . SF-36 scores in these @entity1 were compared with those in a prevalent cohort of hemodialysis (HD) @entity1 and healthy controls (both from historical data). QOL data also were analyzed for correlations with GFR and albumin and hemoglobin levels in multivariable analyses. RESULTS: @entity1 with @entity740 had higher SF-36 scores than a large cohort of HD @entity1 (P < 0.0001 for 8 scales and 2 summary scales), but lower scores than those reported for the US adult population (P < 0.0001 for 7 of 8 scales and 1 of 2 summary scales). @entity1 with @entity740 stage 4 had lower QOL scores than @entity1 with @entity740 stage 5, although differences were not significant. Hemoglobin level was associated positively with higher mental and physical QOL scores (P < 0.05) in all individual and component scales except @entity158 . CONCLUSION: SF-36 scores were higher in this @entity740 cohort compared with HD @entity1 , but lower than in healthy controls. GFR was not significantly associated with QOL. Hemoglobin level predicted both physical and mental domains of the SF-36. Longitudinal studies are needed to define at-risk periods for decreases in QOL during progression of @entity740 .

title: Quality of life in XXXX ( @entity740 ): a cross-sectional analysis in the Renal Research Institute- @entity740 study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

answer: @entity740 :: (MESH:D051436,Disease) :: ['chronic kidney disease']


abstract: The objective of this case report was to describe a @entity1 who developed @entity3029 of @entity12352 after @entity7687 . @entity942 of the tibia ( @entity2091 , @entity3894 or @entity1141 ) is very rare, with an incidence of approximately 1 @entity307 million live births. @entity7687 is preferred over transfemoral amputation for type I @entity9321 . Most of the surgical techniques describe preservation of the @entity12352 and suturing of patellar tendon with cruciate ligaments. We present a case of a 14-year-old @entity1 , who underwent disarticulation through the right knee as a primary procedure at age of 5 months for @entity11767 . At 13 years after the primary procedure, the @entity1 developed @entity158 flicking of the @entity12352 , which was diagnosed clinically as habitual (spontaneous) @entity12351 . In conclusion, @entity196 is associated with marked @entity509 of the distal femur along with retardation of ossification of distal femoral epiphysis. This can later result in @entity8043 . This could delay the rehabilitation of young amputees with @entity7687 . It would be debatable and would need further evidence as to whether excision of the @entity12352 at the initial amputation may be more appropriate to prevent later incidence of dislocation.

title: @entity12351 in @entity7687 stump in a @entity1 of XXXX of tibia: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patient']

entities_list: @entity9321 :: ('MESH:D049310', 'Disease') :: ['tibial deficiency']

entities_list: @entity12351 :: ('MESH:C538081', 'Disease') :: ['dislocation of the patella']

entities_list: @entity2091 :: ('MESH:C535563', 'Disease') :: ['tibial hemimelia']

entities_list: @entity11767 :: ('MESH:C564764', 'Disease') :: ['congenital type I tibia deficiency']

entities_list: @entity509 :: ('MESH:C538429', 'Disease') :: ['hypoplasia']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['type I tibia deficiency']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

entities_list: @entity7687 :: ('MESH:D001184', 'Disease') :: ['Knee disarticulation', 'knee disarticulation']

entities_list: @entity8043 :: ('MESH:D031222', 'Disease') :: ['patellar dislocation']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['Congenital deficiency']

entities_list: @entity3029 :: ('MESH:D004204', 'Disease') :: ['habitual dislocation']

answer: @entity196 :: (MESH:D020754,Disease) :: ['congenital type I deficiency']


abstract: @entity5 growth is dependent on angiogenesis, which is thought to be mediated through growth factors, such as @entity310 ( @entity21222 ( @entity2533 ), @entity4179 ( @entity4179 ), and @entity540 ( @entity540 ), produced by @entity5 cells. We have developed a model system for @entity5 angiogenesis in vitro: @entity5274 formation of @entity1 omentum microvascular endothelial (HOME) cells in type I collagen gels when these cells are co-cultured with @entity5 cells. Exogenously added @entity7790 induced @entity5274 formation of HOME cells in collagen gel. In contrast, @entity2533 inhibited the @entity7790 -induced @entity5274 formation of endothelial cells. We investigated whether @entity5274 formation could be induced in HOME cells in collagen gel when the HOME cells were co-cultured with three @entity418 cell lines, TE1, @entity19078 , and @entity18476 . TE1 and @entity19078 cells expressed both @entity7790 and @entity2533 mRNA, but the level of @entity7790 mRNA in @entity19078 was found to be much lower than in TE1 cells. @entity18476 did not express either @entity7790 or @entity2533 . The @entity5274 formation of HOME cell was induced when they were co-cultured with TE1 cells, while both @entity19078 and @entity18476 cell lines induced @entity5274 formation at much lower rates than TE1. TE1-induced @entity5274 formation of HOME cells was specifically blocked by co-administration of anti- @entity7790 -antibody, but not by anti- @entity540 -antibody. The present study suggests that, in our model system, @entity5 angiogenesis is partly controlled by @entity7790 , possibly through a paracrine pathway.

title: A model system for @entity5 angiogenesis: involvement of XXXX in @entity5274 formation of @entity1 microvascular endothelial cells induced by @entity418 cells.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'esophageal tumor', 'Tumor']

entities_list: @entity310 :: ('7124', 'Gene') :: ['transforming growth factor-alpha']

entities_list: @entity4179 :: ('1950', 'Gene') :: ['epidermal growth factor', 'EGF']

entities_list: @entity540 :: ('2247', 'Gene') :: ['bFGF', 'basic fibroblast growth factor']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity310 :: (7124,Gene) :: ['transforming growth factor-alpha']


abstract: BACKGROUND: A vaccine for enterovirus 71 (EV71) is needed to address the high burden of disease associated with @entity281 . We assessed the efficacy, safety, immunogenicity, antibody persistence, and immunological correlates of an inactivated alum-adjuvant EV71 vaccine. METHODS: We did a randomised, double-blind, placebo-controlled, phase 3 trial. Healthy @entity1 aged 6-35 months from four centres in China were randomly assigned (1:1) to receive vaccine or alum-adjuvant placebo at day 0 and 28, according to a randomisation list (block size 30) generated by an independent statistician. Investigators and @entity1 and their guardians were masked to the assignment. Primary endpoints were EV71-associated @entity5825 ( @entity5825 ) and EV71-associated disease during the surveillance period from day 56 to month 14, analysed in the per-protocol population. This study is registered with ClinicalTrials.gov, number NCT01508247. FINDINGS: 10,245 @entity1 were enrolled and assigned: 5120 to vaccine versus 5125 to placebo. 4907 (with three cases of EV71-associated @entity5825 and eight cases of EV71-associated disease) versus 4939 (with 30 cases of EV71-associated @entity5825 and 41 cases of EV71-associated disease) were included in the primary efficacy analysis. Vaccine efficacy was 90  0% (95% CI 67  1-96  9) against EV71-associated @entity5825 (p=0  0001) and 80  4% (95% CI 58  2-90  8) against EV71-associated disease (p<0  0001). Serious adverse events were reported by 62 of 5117 (1  2%) @entity1 in the vaccine group versus 75 of 5123 (1  5%) in the placebo group (p=0  27). Adverse events occurred in 3644 (71  2%) versus 3603 (70  3%; p=0  33). INTERPRETATION: EV71 vaccine provides high efficacy, satisfactory safety, and sustained immunogenicity. FUNDING: China's 12-5 National Major Infectious Disease Program, Beijing Vigoo Biological.

title: Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in XXXX in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity5825 :: ('MESH:D006232', 'Disease') :: ['HFMD', 'hand, foot, and mouth disease']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: OBJECTIVES: The aim of this study was to investigate the effects of @entity2681 and toothbrush abrasion on different restorative materials and @entity1 enamel. METHODS: @entity1 enamel and 5 kinds of tooth-colored restorative materials were used. The restorative materials included three composite resins (Filtek Silorane, Tetric EvoCeram, and Tetric EvoFlow), a polyacid-modified composite (Dyract Extra), and a conventional glass-ionomer cement (Ketac Fil Plus). For each type of the material, 40 specimens were prepared and embedded in ceramic moulds and divided into four groups (n=10): control group (C), @entity2681 group (E), abrasion group (A), and @entity12893 group ( @entity12893 ). The specimens were subjected to six daily erosive attacks (groups E and @entity12893 ; @entity1792 , pH 2.3, 1 min) and/or six abrasive attacks (groups A and @entity12893 ; toothbrush abrasion, 100 @entity64 , 1 min), while the control specimens (group C) were maintained in artificial saliva. After 10-day treatment, the substance loss and surface changes were determined by surface profilometry and scanning electron microscopy. RESULTS: @entity1 enamel presented higher substance loss when compared to restorative materials. Generally, combined @entity12893 ( @entity12893 ) caused the highest substance loss, followed by @entity2681 , abrasion, and storage in artificial saliva. Composite resin presented highest durability under erosive and/or abrasive attacks. Enamel and restorative materials showed degradation in groups E and @entity12893 through SEM observation. CONCLUSIONS: Toothbrush abrasion has a synergistic effect with @entity2681 on substance loss of @entity1 enamel, polyacid-modified composite and glass-ionomer cement. The acid- and abrasive-resistance of @entity1 enamel was lower compared to restorative materials.

title: Erosion and abrasion of tooth-colored restorative materials and XXXX enamel.

entities_list: @entity12893 :: ('MESH:D014072', 'Disease') :: ['erosion-abrasion', 'EA']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes']

entities_list: @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citric acid']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The long term efficacy and tolerance of @entity11808 were studied in 48 @entity1 with @entity1540 ( @entity1540 ) treated for 6 months. Holter monitoring was performed before treatment and at each dose increment (75 mg/day; 150 mg/day and 225 mg/day) during the first week of titration, and then after 1 month and 6 months of treatment. The dose administered in the long-term study corresponded to the minimum effective dose during the titration phase (the dose which reduced the number of @entity1540 /24 hours by at least 75%). The average number of @entity1540 /hour decreased significantly from 480.6 before treatment to 2.0 at the end of the study. The frequency of episodes of @entity1165 decreased significantly during treatment. The commonest side effects were vertigo, @entity227 and @entity10 . Treatment was interrupted because of side-effects or inefficacy in 6 @entity1 . The surface ECG showed significant lengthening of the PR, QRS and QTc periods and @entity11808 appeared to have aggravated the @entity943 of 4 @entity1 receiving 200 mg/day. The plasma concentrations of @entity11808 and its two principal metabolites were measured during the titration phase, at 1 month and after 6 months of treatment. 15.6 per cent of @entity1 were slow and 84.4% of @entity1 were rapid metabolizers. The wide individual variations of plasma concentrations and the absence of correlation between the plasma concentrations of @entity11808 and its metabolites and the antiarrhythmic effect suggest that the compound and its metabolites play a role in the antiarrhythmic effect of the drug.

title: [Anti- @entity943 effect of long-term XXXX in chronic @entity1540 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbances']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity11808 :: ('MESH:D016700', 'Chemical') :: ['encainide']

entities_list: @entity1540 :: ('MESH:D018879', 'Disease') :: ['chronic/ventricular extrasystoles', 'VES']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']

answer: @entity11808 :: (MESH:D016700,Chemical) :: ['encainide']


abstract: OBJECTIVE: Among @entity1 with @entity0 , hot flashes are frequent, severe, and bothersome symptoms that can negatively impact quality of life and compromise compliance with life-saving medications (eg, @entity440 and aromatase inhibitors). Clinicians' abilities to treat hot flashes are limited due to inadequate understanding of physiological mechanisms involved in hot flashes. Using an acute @entity2340 depletion paradigm, we tested whether alterations in central @entity750 levels were involved in the induction of hot flashes in @entity1 with @entity0 . METHODS: This was a within- @entity1 , double-blind, controlled, balanced, crossover study. Twenty-seven @entity1 completed two 9-hour test days. On one test day, @entity1 ingested a concentrated @entity535 drink and encapsulated @entity1522 (no @entity2340 ) according to published procedures that have been shown to have specific effects on @entity750 within 4.5 to 7 hours. On the other test day, @entity1 ingested a control drink. Serial venous blood sampling and objective hot flash monitoring were used to evaluate response to each condition. RESULTS: Response to acute @entity2340 depletion was variable and unexplained by use of selective @entity750 reuptake inhibitors, antiestrogens, @entity0 and treatment variables, or genetic polymorphisms in @entity750 receptor and transporter genes. Contrary to our hypothesis, hot flashes were not worsened with acute @entity2340 depletion. CONCLUSIONS: Physiologically documented and self-reported hot flashes were not exacerbated by @entity2340 depletion. Additional mechanistic research is needed to better understand the etiology of hot flashes.

title: Evaluating the role of @entity750 in hot flashes after @entity0 using acute XXXX depletion.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'participant']

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast cancer disease']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

answer: @entity2340 :: (CHEBI:27897,Chemical) :: ['tryptophan']


abstract: Clinical ethics teams exist in various forms and have assisted care providers for several decades. Our clinical ethics service at an urban, tertiary, teaching hospital provides ethics consultation to care providers, @entity1 , and their family members. Scenarios prompting an ethics consultation may be complex, often involving social, cultural, and fiscal components. Because @entity1 who receive an ethics consultation often require a lengthy hospital stay, our group searched for unique identifiers in a @entity1 's presentation to facilitate earlier and, potentially, more effective interventions. Of particular interest to our group was the presentation of these @entity1 to our institution from the @entity341 ( @entity341 ). Our group's subjective experience indicated that factors requiring ethics consultation were often present very early during hospitalization. A retrospective medical record review of a convenience sample of 50 records of @entity1 who had received a formal clinical ethics consult within a 14-month timeframe was done. Those @entity1 who were admitted to the hospital via the @entity341 and subsequently received an ethics consultation were identified. The critical issues prompting the ethics consult were then evaluated. Eighteen (35%) of the study @entity1 were originally admitted through the @entity341 . Results showed that the ethical issue(s) that prompted the clinical ethics consult was regularly identifiable in the @entity341 . Our study results indicate that issues prompting ethics consults may potentially be identified as @entity1 present to the @entity341 . Rapid and effective interventions proscribed through institutional policy guidelines could greatly assist nurses and other @entity341 providers in identifying these at-risk @entity1 upon entry of the @entity341 . Such a policy would ultimately benefit both @entity1 and provider.

title: Ethics consultation in the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency department']


abstract: The design and development of antioxidant molecules have lately gained a great deal of focus which is attributed to their immense biomedicinal importance in combating the free radical associated health hazards. In a situation to replenish the endogenous antioxidant loss, synthetic molecules with potent antioxidant activity is demanded. The present work thus aims at in silico modeling of antioxidant molecules that may facilitate in searching and designing of new chemical entities with enhanced activity profile. A series of @entity27469 and @entity14627 derivatives having the ability to inhibit lipid peroxidation have been modeled in the present work. Three different types of models were developed using different chemometric and cheminformatics tools to identify the essential structural attributes: (a) descriptor based QSAR models, (b) 3D pharmacophore models and (c) HQSAR (hologram QSAR) models. For the conventional QSAR modeling, descriptors belonging to different categories [quantum chemical descriptors (Mulliken charges of the common atoms of the molecules), thermodynamic descriptors, electronic descriptors, structural descriptors and spatial descriptors] were calculated for the development of statistically significant as well as well interpretable quantitative structure-activity relationship (QSAR) models. Two different chemometric tools [genetic function approximation (GFA) and genetic partial least squares (G/PLS)] were employed for the development of the QSAR models. The 3D pharmacophore model focused on the essential pharmacophoric features while the HQSAR model implicated the prime structural fragments that were necessitated for the optimal anti-lipid peroxidative activity of the molecules. All the models were validated based on internal, external and overall validation statistics. Randomization was performed in order to ensure the absence of chance correlation in the developed models. Among all models, the descriptor-based model developed using the GFA-spline technique yielded the most satisfactory results. The results obtained from all the models corroborate well with each other and chiefly signify the importance of the ketonic @entity26 of the @entity6346 / acid fragment and the ethereal @entity26 substituted on the parent @entity15060 ring of the molecules under study. Thus the models can efficiently be utilized for extensive screening of large datasets and their subsequent activity prediction.

title: In silico development, validation and comparison of predictive QSAR models for lipid peroxidation inhibitory activity of XXXX and @entity14627 derivatives using multiple chemometric and cheminformatics tools.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity14627 :: ('MESH:C040048', 'Chemical') :: ['caffeic acid']

entities_list: @entity27469 :: ('MESH:C029010', 'Chemical') :: ['cinnamic acid']

answer: @entity27469 :: (MESH:C029010,Chemical) :: ['cinnamic acid']


abstract: @entity649 ( @entity649 ) is characterized by @entity55 . This study explored the inflammatory mediators in @entity5173 ( @entity5173 ) for prognostic relevance in @entity1 with infection-induced @entity649 . Thirty-nine @entity1 with infection-induced @entity649 (28 @entity55 and 11 extrapulmonary sepsis) and two @entity1 with @entity4 as the control were included. The expression profiles of inflammatory mediators in @entity5173 were compared between @entity649 and @entity4 . A group of inflammatory mediators that showed higher expression in @entity649 was analyzed for their relationships with clinical features and outcome. We found that 17 @entity1 who died had higher levels of @entity650 (P = 0.012), @entity687 (P = 0.001) and @entity2842 (P = 0.036) in @entity5173 compared with those who survived. Furthermore, there was an inverse relationship between the @entity5173 levels of @entity650 (P = 0.026), @entity687 (P = 0.008) and @entity10557 (P = 0.048) and the changes of lung compliance between days 1 and 4, whereas the @entity5173 levels of @entity687 (P = 0.033) and @entity10557 (P = 0.029) were positively correlated with the changes of sequential organ failure assessment scores between days 1 and 4. In multivariate logistic regression analysis, only @entity687 (P = 0.013) and @entity651 score (LIS) (P = 0.017) independently predicted the mortality, and @entity687 (P = 0.002) was most likely predictive of mortality in analysis of area under the receiver operating characteristic curve. In conclusion, we show the expression profiles of inflammatory mediators in @entity5173 of infection-induced @entity649 . Among the mediators, @entity687 is the most significant predictor for mortality, and several mediators are correlated with clinical severity. However, potential selection bias due to limited control subjects and lack of serum inflammatory mediator data suggest a necessity of further studies to confirm our findings.

title: Prediction of outcome in XXXX with @entity649 by bronchoalveolar lavage inflammatory mediators.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia', 'overwhelming lung inflammation']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['Acute respiratory distress syndrome', 'ARDS']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['cardiogenic lung edema']

entities_list: @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury']

entities_list: @entity5173 :: ('MESH:D065634', 'Disease') :: ['bronchoalveolar lavage fluid', 'BALF']

entities_list: @entity2842 :: ('6347', 'Gene') :: ['monocyte chemoattractant protein-1']

entities_list: @entity10557 :: ('6348', 'Gene') :: ['macrophage inflammatory protein (MIP)-1 alpha', 'MIP-1 alpha']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Five @entity1 , who had never received any drug treatment but who had severe chronic @entity712 with salt and water retention, were studied before and after a single dose of @entity4688 (10 mg orally). Three @entity1 continued on @entity4688 as monotherapy (10 mg b.d. orally) for one month. Central haemodynamics, body fluid volumes, renal function and plasma hormones were measured at rest. The initial mean right atrial pressure was 13 +/- 4 mm Hg, pulmonary wedge pressure 29 +/- 4 mm Hg and cardiac index 1.8 +/- 0.21/min/m2. @entity4688 , given acutely, caused only small changes. Two @entity1 were withdrawn after the single dose of @entity4688 and treated with diuretics for clinical reasons. The remaining three @entity1 each lost more than 4 kg in weight after one month of treatment with @entity4688 alone. Total body exchangeable @entity1372 and total body water were reduced but central haemodynamics were unchanged. Although @entity4688 was of some benefit when given alone to @entity1 with severe @entity712 , all five @entity1 were finally treated with diuretics for clinical reasons. @entity4688 is not recommended as the initial and only therapy for @entity1 with severe @entity712 .

title: @entity4688 as initial and sole treatment in severe chronic XXXX with @entity1372 retention.

entities_list: @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril', 'Enalapril']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: PURPOSE: The main purpose of this article was to investigate the value of a self-regulation approach for weight reduction interventions in @entity1 with @entity164 2 @entity6 . In addition, the potentially moderating effect of other intervention characteristics was explored. METHODS: In a meta-analysis of 34 studies, overall effect sizes were calculated for weight and @entity3916 . The focus of the analysis was, however, on the moderating effect of intervention characteristics, especially whether interventions that score high on self-regulation produce stronger effects. RESULTS: The overall effect sizes (d) for @entity353 in the short term (<6 months) were low and even lower in the longer term (>6 months). The overall effect sizes for @entity3916 outcomes were higher and remained stable in the longer term. Interventions that scored high on self-regulation characteristics produced significantly better effects on both weight and @entity3916 outcomes. Furthermore, "goal reformulation" increased the effect on weight outcomes whereas "emotion regulation" increased the effect on @entity3916 . With respect to the other intervention characteristics, only the "inclusion of a @entity1 's partner or relative" increased the effect on @entity353 . CONCLUSIONS: This meta-analysis underlines the importance of a self-regulation approach for weight reduction interventions in @entity6 @entity1 , in particular, for @entity3916 outcomes. However, more research is needed to fully understand the relationship among self-regulation, weight, and @entity3916 .

title: The effect of weight reduction interventions for @entity1 with XXXX 2 @entity6 : a meta-analysis from a self-regulation perspective.

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: OBJECTIVES: @entity3181 ( @entity3181 ) is a poorly understood entity in urology. It results from @entity409 . It has been infrequently reported to be secondary to hepatic @entity432 from invasion by an inferior vena cava (IVC) @entity5 thrombus in @entity1358 ( @entity1358 ). We report the largest known series of @entity1 with @entity1358 and @entity3181 . @entity1 AND METHODS: Ten @entity1 presented to a tertiary hospital with locally advanced @entity1358 with IVC @entity5 thrombus. All were evaluated and had clinical or radiographic evidence of @entity3181 . All underwent nephrectomy, IVC thrombectomy or ligation, and @entity5 removal from the hepatic veins. The perioperative and pathological factors were measured. These included estimated @entity190 (EBL) and transfusions. Inpatient factors including duration of intubation, length of intensive care unit (ICU) stay, and overall length of stay (LOS) were recorded. The @entity5 -free status was evaluated. RESULTS: The average age was 59 years. No intraoperative @entity204 occurred. Two intraoperative complications were noted. The mean EBL was 4244 cc; mean surgery length was 8 hours 12 minutes; and the mean ICU stay was nine days. The overall LOS averaged 13.25 days. One @entity1 died postoperatively of @entity295 and @entity881 . One @entity1 required reoperation for an @entity1410 caused by subcutaneous enoxaparin administration. Average follow-up was 28 months. Five @entity1 are alive with no evidence of disease. CONCLUSIONS: @entity3181 is a rare entity in urology, with a potential for significant morbidity and mortality. Surgical excision of the primary @entity5 along with thrombectomy results in alleviation of @entity3181 and improvement in the @entity1 .

title: @entity3181 in urology: Impact on nephrectomy for advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['obstruction of the hepatic veins and the subsequent complications']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['abdominal wall hematoma']

entities_list: @entity3181 :: ('MESH:D006502', 'Disease') :: ['Budd-Chiari syndrome', 'BCS']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multisystem organ failure']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['venous obstruction']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']


abstract: The sources of shockwave generation include electrohydraulic, electromagnetic and piezoelectric principles. Electrohydraulic shockwaves are high-energy acoustic waves generated under water explosion with high voltage electrode. Shockwave in urology (lithotripsy) is primarily used to disintegrate urolithiasis, whereas shockwave in orthopedics (orthotripsy) is not used to disintegrate tissues, rather to induce tissue repair and regeneration. The application of extracorporeal shockwave therapy (ESWT) in @entity85 has been around for more than a decade and is primarily used in the treatment of sports related over-use tendinopathies such as @entity3444 of the heel, @entity2633 of the elbow, @entity730 or non- @entity730 @entity924 of the shoulder and patellar @entity924 etc. The success rate ranged from 65% to 91%, and the complications were low and negligible. ESWT is also utilized in the treatment of non-union of long bone @entity174 , @entity2738 , chronic @entity6 and @entity741 . The vast majority of the published papers showed positive and beneficial effects. FDA (USA) first approved ESWT for the treatment of @entity3444 in 2000 and @entity2633 in 2002. ESWT is a novel non-invasive therapeutic modality without surgery or surgical risks, and the clinical application of ESWT steadily increases over the years. This article reviews the current status of ESWT in @entity85 .

title: Extracorporeal shockwave therapy in XXXX .

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic and non-diabetic ulcers']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinopathy', 'tendonitis']

entities_list: @entity3444 :: ('MESH:D036981', 'Disease') :: ['proximal plantar fasciitis']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcific']

entities_list: @entity2633 :: ('MESH:D013716', 'Disease') :: ['lateral epicondylitis']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal disorders']

entities_list: @entity2738 :: ('MESH:D005271', 'Disease') :: ['avascular necrosis of femoral head']

answer: @entity85 :: (MESH:D009140,Disease) :: ['musculoskeletal disorders']


abstract: 1. The cyclic photosynthetic chain of @entity10052 has been reconstituted incorporating into phospholipid liposomes containing @entity12931 -10 two multiprotein complexes: the reaction center and the @entity15401 -cytochrome-c2 reductase (or bc1 complex). 2. In the presence of cytochrome c2 added externally, at concentrations in the range 10-10(4) nM, a flash-induced cyclic electron transfer can be observed. In the presence of @entity11382 , an inhibitor of the @entity3276 -reducing site of the bc1 complex, the reduction of cytochrome b561 is a consequence of the donation of electrons to the photo-oxidized reaction center. At low ionic strength (10 mM @entity4338 ) and at concentrations of cytochrome c2 lower than 1 microM, the rate of this reaction is limited by the concentration of cytochrome c2. At higher concentrations the reduction rate of cytochrome b561 is controlled by the concentration of @entity9151 in the membrane, and, therefore, is increased when the ubiquinone pool is progressively reduced. At saturating concentrations of cytochrome c2 and optimal redox poise, the half-time for cytochrome b561 reduction is about 3 ms. 3. At high ionic stength (200 mM @entity4338 ), tenfold higher concentrations of cytochrome c2 are required for promoting equivalent rates of cytochrome-b561 reduction. If the absolute values of these rates are compared with those of the cytochrome-c2-reaction-center electron transfer, it can be concluded that the reaction of oxidized cytochrome c2 with the bc1 complex is rate-limiting and involves electrstatic interactions. 4. A significant rate of intercomplex electron transfer can be observed also in the absence of cytochrome c2; in this case the electron donor to the recation center is the cytochrome c1 of the oxidoreductase complex. The oxidation of cytochrome c1 triggers a normal electron transfer within the bc1 complex. The intercomplex reaction follows second-order kinetics and is slowed at high ionic strength, suggesting a collisional interaction facilitated by electrostatic attraction. From the second-order rate constant of this process, a minimal bidimensional diffusion coefficient for the complexes in the membrane equal to 3 X 10(-11) cm2 s-1 can be evaluated.

title: Kinetics of photosynthetic electron transfer in artificial vesicles reconstituted with purified complexes from XXXX . II. Direct electron transfer between the reaction center and the bc1 complex and role of cytochrome c2.

entities_list: @entity10052 :: ('1061', 'Species') :: ['Rhodobacter capsulatus']

entities_list: @entity15401 :: ('MESH:C003741', 'Chemical') :: ['ubiquinol']

entities_list: @entity12931 :: ('MESH:D014451', 'Chemical') :: ['ubiquinone']

entities_list: @entity11382 :: ('MESH:C032456', 'Chemical') :: ['antimycin']

answer: @entity10052 :: (1061,Species) :: ['Rhodobacter capsulatus']


abstract: OBJECTIVE: We conducted a randomized, double-blind, placebo-controlled efficacy and tolerability trial of Matricaria recutita (chamomile) extract therapy in @entity1 with mild to moderate @entity148 ( @entity148 ). We hypothesized that chamomile would be superior to placebo in @entity146 with a comparable tolerability profile. MATERIALS AND METHODS: Sixty-one outpatients with mild to moderate @entity148 were enrolled, and 57 were randomized to either double-blind chamomile extract (n = 28) or placebo therapy (n = 29) for 8 weeks. The study was powered to detect a statistically significant and clinically meaningful group difference in change over time in total Hamilton Anxiety Rating (HAM-A) scores. Secondary outcomes included change in the Beck Anxiety Inventory, Psychological Well Being, and Clinical Global Impression Severity scores and the proportion of @entity1 with 50% reduction or more in baseline HAM-A score. RESULTS: We observed a significantly greater reduction in mean total HAM-A score during chamomile versus placebo therapy (P = 0.047). Although the study was not powered to identify small to moderate differences in secondary outcomes, we observed a positive change in all secondary outcomes in the same direction as the primary outcome measure. One @entity1 in each treatment group discontinued therapy for adverse events. The proportion of @entity1 experiencing 0, 1, 2, or 3 adverse events or more was not significantly different between groups (P = 0.417). CONCLUSIONS: This is the first controlled clinical trial of chamomile extract for @entity148 . The results suggest that chamomile may have modest anxiolytic activity in @entity1 with mild to moderate @entity148 . Future studies are needed to replicate these observations.

title: A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['GAD', 'generalized anxiety disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['reducing GAD symptoms']

answer: @entity148 :: (MESH:D001008,Disease) :: ['generalized anxiety disorder']


abstract: @entity5 budding is recognized as an adverse prognostic factor for a few @entity189 types. We evaluated the importance of this finding in 64 @entity189 @entity1 treated with surgery and radiotheraphy, with a median follow up of 53 (6-181) months. Budding was determined by re-evaluating @entity1710 - @entity1711 (H_E) stained @entity5 sections, and classified as mild, moderate, and marked. Budding was not identified in 14 (21.88%) cases. Mild, moderate, and marked budding was observed in 21 (32.81%), 15 (23.44%), and 14 (21.88%) cases, respectively. Only when cases with marked budding were compared with the others, statistically significant results were obtained. In @entity1 with and without marked budding, local disease-free survival, metastatic disease-free survival, and overall survival were 71% and 97% (p=0.72), 77% and 93% (p=0.038), and 77% and 75% (p=0.71), respectively. Marked budding was identified as a prognostic factor by univariate analysis for distant @entity3 -free survival. Multi-variate analysis, by which well-recognized prognostic histopathologic parameters were evaluated, revealed that only the number of metastatic lymph nodes and budding were significantly associated with distant @entity3 (p=0.02 and p=0.044), respectively. These results suggest that budding might be a valuable prognostic factor, particularly for distant @entity3 in @entity189 .

title: XXXX budding as a prognostic marker in @entity189 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['laryngeal carcinomas', 'laryngeal carcinoma', 'carcinoma']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Tumor']


abstract: BACKGROUND/OBJECTIVES: Individuals with type 1 @entity6 have a high risk of developing @entity65 , and it has been reported that they consume a high atherogenic diet. We examined how nutrient intake and adherence to current European nutritional recommendations evolved in a large cohort of European individuals with type 1 @entity6 over a period of 7 years. SUBJECTS/METHODS: We analysed data from the EURODIAB Prospective Complications Study, a European multicentre prospective cohort study. Standardized 3-day dietary records were employed in individuals with type 1 @entity6 . One thousand one hundred and two @entity1 (553 @entity1 , 549 @entity1 , baseline age 33    10 years, duration 15    9 years) had complete nutritional data available at baseline and after 7 years. We calculated mean differences in reported nutrients over time and adjusted these for age, gender, HbA1c and BMI with ANOVA models. RESULTS: Compared to baseline, there were minor changes in nutrients. Reported protein (-0.35% energy (en), @entity23138 (-1.07% en), saturated @entity23138 (-0.25% en) and @entity165 (-7.42 mg/1000 kcal) intakes were lower, whereas @entity1735 (+1.23% en) and fibre (+0.46 g/1000 kcal) intakes were higher at the 7-year follow-up. European recommendations for adequate nutrient intakes were followed in individuals with type 1 @entity6 for protein (76% at baseline and 78% at follow-up), moderately for @entity23138 (34, 40%), @entity1735 (34, 41%) and @entity165 (39, 47%), but poorly for fibre (1.4, 2.4%) and saturated @entity23138 (11, 13%). CONCLUSION: European individuals with type 1 @entity6 consume a high atherogenic diet as few @entity1 met recommendations for dietary fibre and saturated @entity23138 . This study showed minor changes in dietary nutrients and energy intakes over a period of 7 years. Nutrition education needs particular focus on strategies to increase dietary fibre and reduce saturated @entity23138 to exploit their potential benefit.

title: Do European XXXX with type 1 @entity6 consume a high atherogenic diet? 7-year follow-up of the EURODIAB Prospective Complications Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: PURPOSE: To study the additive value of deep sclerectomy to the procedure of combined trabeculotomy-trabeculectomy with @entity1138 (CTTM) for the treatment of primary @entity10064 . STUDY DESIGN: This study is a prospective, randomized case series. @entity1 AND METHODS: The study was conducted on 20 eyes of 20 @entity1 with primary @entity10064 presenting to the Department of Ophthalmology of the Alexandria Main University Hospital. Preoperative examination under anesthesia was followed by surgical intervention. Postoperative examinations were conducted immediately after surgery and at 1, 2, 3, 6, 9, and 12 months. Intraoperative and postoperative complications, as well as operative time, were recorded. RESULTS: The mean (  SD, range) age of the study @entity1 in the CTTM group and in the combined trabeculotomy-trabeculectomy with @entity1138 with deep sclerectomy (CTTM-DS) group was 4.7 (  2.0, 2-8) and 7.0 (  3.8, 3-13) months, respectively. The mean (  SD, range) preoperative intraocular pressure (IOP) in the CTTM and CTTM-DS groups was 16.7 (4.3, 10-26) and 16.4 (8.4, 8-36), respectively, and these dropped at 12 months of follow-up to 4.9 (2.0, 2-8) and 5.6 (3.3, 2-10), respectively. The mean (  SD, range) of the duration of the operation in the CTTM and the CTTM-DS was 57 (  8, 50-71)   min and 53 (  7, 42-64)   min, respectively (P=0.428). Two eyes (20%) in the CTTM-DS group developed @entity8814 disc @entity4 at the first 2 months and resolved spontaneously thereafter. No other complications were noted in either of the groups. CONCLUSION: The addition of deep sclerectomy to the procedure of CTTM in pediatric @entity726 surgery facilitates the finding of Schlemm's canal, shortens the duration of surgery, and is not associated with any additional complications. Hence, the author recommends the addition of deep sclerectomy to CTTM surgery for primary @entity10064 .

title: Deep sclerectomy in pediatric XXXX filtering surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity10064 :: ('MESH:C565547', 'Disease') :: ['congenital glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['glaucoma']


abstract: Malabsorption (M) is characterized by absorption defect of one or several nutriments in small bowel. Its clinical expression is rarely obvious and biological signs are: anaemia, low serum protein, albumin and lipid rates, low serum @entity460 , @entity3151 and @entity972 level, and hypoprothrombinaemia. But only 4 simple and reliable tests are needed for diagnosis: i. e.: daily faecal fat amount measurement, daily faecal @entity1568 excretion, the xylose test and the Schilling's test. This syndrome is related to many conditions which can be divided into 2 groups with and without @entity1944 . The relationships between M and @entity272 belong to 4 types (J. Marks and S. Shuster): 1) M is responsible for the cutaneous signs, 2) M is caused by a @entity272 , 3) both M and @entity272 are the result of a same cause, 4) M and @entity272 are associated in an indirect way. Only the two first types are dealt with in this report. Skin manifestations occur as a complication in 10 p. 100 to 20 p. 100 of cases of M. They are mostly polymorphous or non-specific, as they are related to multiple @entity2221 or essential @entity535 deficiencies and heal with the treatment of M. The main conditions encountered are diffuse pigmentation, acquired @entity5657 , @entity9284 , nail @entity6926 and hair loss. Mucous membrane lesions, purpura and eczematoid or @entity1569 -like @entity1909 have also been described. More uncommon are clubbing of fingers, finger print abnormalities, @entity16995 or @entity9253 . The @entity7017 , i. e. a @entity8884 due to a @entity272 , occurs as a result of widespread involvement of the body for instance in @entity1569 or @entity484 ; its clinical expression is rarely obvious, the histological record of gut biopsy usually normal and the results of biological tests often dissociated, but steatorrhoea is frequently found. The pathogenesis of the condition is still unknown but its importance is related to the extent of the @entity272 and it only improves with the treatment of the latter. All these features and others are discussed in the report with a comprehensive review of the literature.

title: [Cutaneous manifestations of XXXX (author's transl)].

entities_list: @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal abnormalities']

entities_list: @entity16995 :: ('MESH:D007732', 'Disease') :: ['kwashiorkor']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity9253 :: ('MESH:C538178', 'Disease') :: ['acrodermatitis enteropathica-like eruptions']

entities_list: @entity8884 :: ('MESH:D008286', 'Disease') :: ['M syndrome']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity7017 :: ('MESH:C538273', 'Disease') :: ['dermatogenic enteropathy']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease', 'skin diseases']

entities_list: @entity9284 :: ('MESH:D007642', 'Disease') :: ['follicular keratosis']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity2221 :: ('CHEBI:33229', 'Chemical') :: ['vitamin']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

entities_list: @entity6926 :: ('MESH:D010013', 'Disease') :: ['brittleness']

entities_list: @entity5657 :: ('MESH:D007057', 'Disease') :: ['ichthyosis']

answer: @entity8884 :: (MESH:D008286,Disease) :: ['malabsorption diseases']