abstract: Community-acquired @entity55 is one of the most common infectious conditions that require hospitalization. When intravenous treatment is indicated, cefonicid is usually the drug of choice. The aim of this study was to find out if @entity2755 , which is superior to the standard drugs from a financial point of view, could serve as an equally efficient treatment, especially in the elderly. The outcomes of 3 @entity55 @entity1 groups who were either treated with cefonicid, @entity2755 or @entity114 -G (n = 59, 17, 24, respectively) were retrospectively compared. Data about demographic characteristics of the @entity1 , clinical outcomes, rehospitalization rates, duration of improvement/treatment/ hospitalization and clinical laboratory tests were obtained from each @entity1 's medical records. Only minor differences (even though occasionally significant) were found with respect to rehospitalization and improvement rates, duration of hospitalization, treatment and improvement, @entity204 rates and clinical laboratory tests. However, @entity2755 @entity1 were found to be significantly older than cefonicid @entity1 . Moreover, no bone-marrow suppression was associated with @entity2755 treatment. @entity5953 drugs tested seem to have the same efficacy. We conclude that since @entity2755 is as safe as, and much cheaper than cefonicid, this antibiotic agent is not inferior to the others, its usage in older @entity1 with @entity55 should be considered.

title: Comparative clinical study of cefonicid, XXXX , and @entity114 in community-acquired @entity55 .

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity2755 :: ('MESH:D002701', 'Chemical') :: ['chloramphenicol']

answer: @entity2755 :: (MESH:D002701,Chemical) :: ['chloramphenicol']


abstract: Shiftwork is associated with an increased risk of @entity65 , but the possible role of @entity32 in this relationship is not well known. We tested the hypothesis that shiftwork would be associated with higher levels of @entity1851 ( @entity1851 ) and increased leukocyte count. We analyzed the cross-sectional associations between work arrangements and low-grade @entity32 in 1877 airline-company employees separately for @entity1 (n   =   1037) and @entity1 (n   =   840). The @entity1 were classified into five categories according to their work schedule: day workers who have not worked in shifts (referent group), former shiftworkers, 2-shift workers, 3-shift workers, and in-flight workers. In models adjusted for age and recent infectious diseases, @entity1851 levels were higher among male 3-shift workers (p = .002) and marginally higher in male 2-shift workers (p = .076). In addition, leukocyte count was higher in 2-shift (p = .005) and 3-shift (p = .021) working @entity1 . In @entity1 , @entity1851 level was higher in 2-shift workers (p = .028), whereas leukocyte count was lower in flight workers (p = .005). Any separate adjustment additionally for smoking, education, @entity167 consumption, physical activity, and @entity28 did not substantially affect the results of 2- and 3-shift work. In the fully adjusted model, only the association between 3-shift work and @entity1851 in @entity1 (p = .021) and 2-shift work and leukocyte count in @entity1 (p = .020) and leukocyte count in 3-shift-working @entity1 (p = .044) were significant. Our results suggest that 2- and 3-shift work is associated with @entity32 and the relationship is relatively independent of the considered risk factors of @entity65 .

title: Effect of shiftwork on systemic markers of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'increased systemic inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases', 'cardiovascular disease']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: AIMS: To investigate the effect of age and gender on the tolerability, safety and pharmacokinetics (PK) of tomopenem ( @entity22800 / @entity22800 ), a novel @entity2893 antibiotic, and its major metabolite. METHODS: Forty-two subjects were assigned to one of the following three groups: young @entity1 , elderly @entity1 and elderly @entity1 . The PK, safety and tolerability of an intravenous infusion of 1500 mg tomopenem and its resultant major metabolite (open @entity3405 ring) were assessed. RESULTS: Minor differences in exposure of both tomopenem and the major metabolite were seen. The area under the curve (AUC) of tomopenem was 22% higher in elderly @entity1 compared with young @entity1 , and 19% higher in elderly @entity1 relative to the elderly @entity1 . Total clearance of tomopenem decreased with decreasing @entity1011 clearance. In the two male groups, renal clearance values of tomopenem were similar (3.52 and 3.67 l h(-1)) and higher than in the elderly female group (2.83 l h(-1)). The mean half-lives ranged from 2.03 (healthy young @entity1 ) to 2.41 h (elderly @entity1 ). The difference in AUC of tomopenem can be explained by differences in the mean @entity1011 clearances of 116 (young @entity1 ), 101 (elderly @entity1 ) and 84.7 (elderly @entity1 ) ml min(-1) 1.73 m(-2), respectively. CONCLUSIONS: While some PK parameters were statistically different among the three groups, the differences were mostly minor and unlikely to be clinically meaningful. The difference in the PK can be largely attributed to the difference in @entity1011 clearance of these groups.

title: Lack of age and gender effects on single-dose pharmacokinetics of @entity22800 ( @entity22800 / @entity22800 ), a novel XXXX .

entities_list: @entity3405 :: ('CHEBI:35627', 'Chemical') :: ['beta-lactam']

entities_list: @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity2893 :: (CHEBI:46765,Chemical) :: ['carbapenem']


abstract: AIMS: To conduct a systematic review with meta-analysis of randomized controlled trials (RCTs) that have assessed the efficacy of intraoral orthopedic appliances to reduce @entity158 in @entity1 with @entity2956 affecting muscle and joint (TMJD) compared to subjects receiving placebo control, no treatment, or other treatments. METHODS: A search strategy of MEDLINE, the Cochrane Library, the Cochrane CENTRAL Register, and manual search identified all English language publications of RCTs for intraoral appliance treatment of @entity158 during the years of January 1966 to March 2006. Two additional studies from 2006 were added during the review process. Selection criteria included RCTs assessing the efficacy of hard and soft stabilization appliances, anterior positioning appliances, anterior bite appliances, and other appliance types for @entity158 . @entity158 relief outcome measures were used in the meta-analyses, and the QUORUM criteria for data abstraction were used. A quality analysis of the methods of each RCT was conducted using the CONSORT criteria. The review findings were expressed both as a qualitative review and, where possible, as a mathematical synthesis using meta-analysis of results. RESULTS: A total of 47 publications citing 44 RCTs with 2,218 subjects were included. Ten RCTs were included in two meta-analyses. In the first meta-analysis of seven studies with 385 @entity1 , a hard stabilization appliance was found to improve @entity158 compared to non-occluding appliance. The overall odds ratio (OR) of 2.46 was statistically significant (P = .001), with a 95% confidence interval of 1.56 to 3.67. In the second meta-analysis of three studies including 216 @entity1 , a hard stabilization appliance was found to improve @entity158 compared to no-treatment controls. The overall OR of 2.15 was positive but not statistically significant, with a 95% confidence interval of 0.80 to 5.75. The quality (0 to 1) of the studies was moderate, with a mean of 55% of quality criteria being met, suggesting some susceptibility to systematic bias may have existed. CONCLUSION: Hard stabilization appliances, when adjusted properly, have good evidence of modest efficacy in the treatment of @entity158 compared to non-occluding appliances and no treatment. Other types of appliances, including soft stabilization appliances, anterior positioning appliances, and anterior bite appliances, have some RCT evidence of efficacy in reducing @entity158 . However, the potential for adverse events with these appliances is higher and suggests the need for close monitoring in their use.

title: Systematic review and meta-analysis of randomized controlled trials evaluating intraoral orthopedic appliances for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['temporomandibular disorders']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'TMJD pain', 'pain']

answer: @entity2956 :: (MESH:D013705,Disease) :: ['temporomandibular disorders']


abstract: STUDY OBJECTIVES: To screen the @entity5395 promoter for polymorphisms and investigate the phenotypic associations of these polymorphisms with diurnal preference, delayed @entity25 (DSPD/DSPS), and their effects on reporter gene expression. DESIGN: Interspecific comparison was used to define the approximate extent of the @entity5395 promoter as the region between the transcriptional start site and @entity377 position -874. This region was screened in DNA pools using PCR and direct sequencing, which was also used to screen DNA from individual @entity1 . The different promoter alleles were cloned into a luciferase expression vector and a deletion library created. Promoter activation was measured by chemiluminescence. SETTING: N/A. @entity1 OR @entity1 : DNA samples were obtained from volunteers with defined diurnal preference (3 x 80, selected from a pool of 1,590), and DSPD @entity1 (n=23). INTERVENTIONS: N/A. MEASUREMENTS AND RESULTS: We verified three single nucleotide polymorphisms ( @entity24623 , @entity24624 , @entity24625 ), and found a novel variable number tandem repeat (VNTR) polymorphism (-318 1/2 VNTR). The -320T and -319A alleles occurred more frequently in DSPD compared to morning (P = 0.042 for each) or evening types (P = 0.006 and 0.033). The allele combination TA2G was more prevalent in DSPD compared to morning (P 0.033) or evening types (P = 0.002). Luciferase expression driven by the TA2G combination was greater than for the more common GC2A (P < 0.05) and the rarer TA1G (P < 0.001) combinations. Deletion reporter constructs identified two enhancer regions (-703 to -605, and -283 to -80). CONCLUSIONS: Polymorphisms in the @entity5395 promoter could affect its expression, leading to potential differences in the observed functions of @entity5395 .

title: Polymorphism in the @entity5395 promoter associates with diurnal preference and delayed XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PATIENTS', 'PARTICIPANTS']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep phase disorder/syndrome']

answer: @entity25 :: (MESH:D012893,Disease) :: ['sleep phase disorder']


abstract: UNASSIGNED: Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding @entity3646 is regulated by inducible or constitutive factors. @entity19767 is one of constitutive transcription factors binding to the @entity3646 promoter. The recently identified @entity19768 protein is similar to @entity19767 , with both sharing high levels of homology in their @entity219 finger motifs. However, the role of @entity19768 in T cells is unclear. @entity19767 and @entity19768 were constitutively expressed in EL4 T cells, and their expression was not dependent on stimulation. @entity3646 promoter (-741/+56 fragment) activity was enhanced by @entity19767 , but inhibited by @entity19768 . The enhanced @entity3646 promoter activity by @entity19767 was reduced by simultaneous expression of @entity19768 . In addition, the DNA binding affinity of @entity19767 to the @entity3646 promoter was adversely affected by @entity19768 . Our results suggest that @entity19767 and @entity19768 exert opposing effects on the @entity3646 promoter as they compete for the same DNA binding sites.

title: XXXX and Yin-Yang 2 exert opposing effects on the promoter activity of @entity3646 .

answer: @entity19767 :: (7528,Gene) :: ['Yin-Yang 1']


abstract: The nuclear DNA content of @entity982 -embedded materials was measured by microfluorometry in 108 @entity14 and 29 metastatic @entity96 from the colorectum. The classification of the nuclear DNA distribution is as follows: Low ploidy, 10% greater than over 4C; intermediate ploidy, 10% less than or equal to over 4C and 10% greater than over 6C; high ploidy, 10% less than or equal to over 6C. In primary lesions, thirty-one (29%) were found to contain cells with high ploidy. The ploidy pattern was not related to pathological stage. However, in curatively resected cases, only 24% of @entity1 with high ploidy survived 10 years. This 10 year-survival rate was significantly lower as compared with 80% and 88% of @entity1 with intermediate and low ploidy, respectively (p less than 0.05). In non-curatively resected cases, no @entity1 with high ploidy survived 2 years, although 21% and 67% of @entity1 with intermediate and low ploidy survived, respectively. In metastatic liver lesions, eleven materials (42%) were found to contain cells with high ploidy. Prognosis of @entity1 with high ploidy was worse than that with intermediate and low ploidy (p less than 0.05). These observations suggest that the nuclear DNA distribution in @entity14 may be an important prognostic factor, independent of pathological stage.

title: [Clinicopathological studies of nuclear DNA distribution in XXXX ].

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal (59 colon and 49 rectal) cancers']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: INTRODUCTION: Data on the metabolic effects of resistance exercise (strength training) in adolescents are limited. PURPOSE: The objective of this study was to determine whether a controlled resistance exercise program without dietary intervention or weight loss reduces body fat accumulation, increases lean body mass, and improves insulin sensitivity and @entity413 metabolism in sedentary @entity28 Hispanic adolescents. METHODS: Twelve @entity28 adolescents (age = 15.5    0.5 yr, body mass index = 35.3    0.8 kg  m; 40.8%    1.5% body fat) completed a 12-wk resistance exercise program (two times 1 h  wk, exercising all major muscle groups). At baseline and on completion of the program, body composition was measured by dual-energy x-ray absorptiometry, abdominal fat distribution was measured by magnetic resonance imaging, hepatic and intramyocellular fat was measured by magnetic resonance spectroscopy, @entity1897 was measured by the stable-label intravenous @entity413 tolerance test, and @entity99 was measured by the @entity99 index = 1000/(GPR   fasting insulin). @entity413 production rate (GPR), gluconeogenesis, and glycogenolysis were quantified using stable isotope gas chromatography/mass spectrometry techniques. RESULTS: All @entity1 were normoglycemic. The exercise program resulted in significant strength gain in both upper and lower body muscle groups. Body weight increased from 97.0    3.8 to 99.6    4.2 kg (P < 0.01). The major part (   80%) was accounted for by increased lean body mass (55.7    2.8 to 57.9    3.0 kg, P  <= 0.01). Total, visceral, hepatic, and intramyocellular fat contents remained unchanged. Hepatic insulin sensitivity increased by 24%    9% (P < 0.05), whereas @entity1897 did not change significantly. GPR decreased by 8%    1% (P < 0.01) because of a 12%    5% decrease in glycogenolysis (P < 0.05). CONCLUSIONS: We conclude that a controlled resistance exercise program without weight loss increases strength and lean body mass, improves @entity99 , and decreases GPR without affecting total fat mass or visceral, hepatic, and intramyocellular fat contents.

title: Strength exercise improves muscle mass and XXXX in @entity28 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral insulin sensitivity']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic insulin sensitivity']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

answer: @entity99 :: (MESH:D056486,Disease) :: ['hepatic insulin sensitivity']


abstract: The objective of the present study was to retrospectively analyze a cohort of @entity1 who underwent surgery for @entity14 during a 12-year period. @entity1 AND METHODS: The sample included 75 @entity1 who were monitored in terms of overall survival (OS) and disease-free interval (DFI) in relation to @entity1 's age, preoperative values of biomarkers, type of surgery, number and size of @entity3 , occurrence of complications and length of hospitalisation. RESULTS: A total of 95 surgical interventions were performed and 133 @entity3 were removed. Out of these, 28% of @entity1 were free of any signs of relapse or disease progression for 5 years after metastasectomy. Those with two or more @entity3 are 2.3-times more at risk of disease progression. Tissue polypeptide specific antigen (TPS) values above the 140 IU/l cut-off point increase the risk of progression 3.9-times. The five-year survival rate among the group was 45%. @entity1 with 2 or more @entity3 are 2.7-times more at risk of @entity204 . TPS values above the 140 IU/l cut-off increase the risk of @entity204 5.5 times, and @entity1735 antigen CA19-9 values above the 28 IU/ml cut-off point increase the risk of @entity204 by 3.2 times. CONCLUSION: The number of @entity3 and the preoperative TPS values are decisive prognostic factors influencing both OS and DFI.

title: Surgical treatment of XXXX : 12-year results.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer pulmonary metastases']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer pulmonary metastases']


abstract: Research investigating associations between specific genes and individual differences with regards to the quality and timing of sleep has primarily focussed on @entity750 -related and @entity16067 genes. However, there are only a few studies of this type and most of those to date have not considered the possibility of gene-environment interaction. Here, we describe associations between @entity25 and diurnal preference and three functional polymorphisms: @entity16068 , @entity5395 , and @entity16067 3111. Furthermore, we assessed whether associations between genotypes and sleep phenotypes were moderated by negative life events-a test of gene-environment interaction. DNA from buccal swabs was collected from 947 individuals [mean age = 20.3 years (SD = 1.77), age range = 18-27 years; 61.8% female] and genotyped for the three polymorphisms. @entity1 completed the Pittsburgh Sleep Quality Index and the Morningness-Eveningness Questionnaire. There was a significant main effect of @entity16068 on @entity25 , indicating that "long-long" homozygotes experienced significantly poorer @entity25 (mean = 6.35, SD = 3.36) than carriers of at least one "short" allele (mean = 5.67, SD = 2.96; b = -0.34, P = 0.005). There were no main effects of @entity16068 on diurnal preference; no main effects of @entity5395 or @entity16067 on @entity25 or diurnal preference; and no significant interactions with negative life events. The main effect of the "long" @entity16068 allele contradicts previous research, suggesting that perhaps the effects of this gene are heterogeneous in different populations. Failure to replicate previous research in relation to @entity5395 and @entity16067 concurs with previous research suggesting that the effects of these genes are small and may be related to population composition.

title: Sleep quality and diurnal preference in a sample of young adults: associations with XXXX , @entity5395 , and @entity16067 3111.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep quality']

answer: @entity16068 :: (6532,Gene) :: ['5HTTLPR']


abstract: UNASSIGNED: Background: The management of @entity1 with @entity955 ( @entity955 ) has substantially improved in recent years, among others due to the introduction of new risk scores for the stratification of @entity1 , as well as the availability of the non- @entity2067 oral antagonists (NOAC). The PREFER-in- @entity955 study aimed to document the management of @entity955 @entity1 with particular focus on @entity64 prevention on the basis of anticoagulants. Methods and results: In Germany, Austria and Switzerland a total of 1771 @entity1 were enrolled between January 2012 and January 2013 (mean age 71.9        9.2 years; 63   % males).At inclusion, the mean time since @entity955 diagnosis was 4.8        5.3 years. @entity955 was present in 30.7   %, persistent in 11   %, long standing persistent in 4.7   % and permanent @entity955 in 53.3   % of the @entity1 . 25.1   % of the @entity1 were in sinus rhythm. Mean CHA2DS2-VASc Score was 3.7        1.8 points (0 points in 3.0   %, 1 point in 7.1   %, >=    2 points in 89.9   %).For the prevention of @entity1031 events 68.1   % of @entity1 received @entity2067 antagonists (VKA, mainly @entity3924 ), 11.6   % received a NOAC (mainly @entity3925 or @entity3926 ), 7.6   % an antiplatelet agent, and 7.7   % a combination of VKA plus an antiplatelet agent. 5.0   % of @entity1 did not receive any anticoagulant. During the 12 months prior to inclusion, interruption of VKA therapy due to an interventions was reported in 29.7   %. In the group of @entity1 with known INR values and available CHA2DS2-VASc score, 75.1   % were adequately controlled (defined as at least 2 of 3 INR values in the range of 2.0-3.0).Bleeding propensity or bleedings in @entity1 history were reported for 5.1   % of the @entity1 , hospitalizations due to major @entity548 events in the past 12 months for 1.9   %. Possible risk factors associated with anticoagulation were present in 76.7   %. Mean HAS-BLED score was 2.1        1.1 points. Conclusion: The rates of @entity955 @entity1 who received oral anticoagulation were about 90   % and substantially higher compared to previous observational studies. NAOCs were administered to 11.7   % of @entity1 .

title: [Risk-adapted anticoagulation in @entity955 in Germany, Austria and Switzerland - an analysis from the PREFER-in- XXXX study].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity3924 :: ('MESH:D010644', 'Chemical') :: ['phenprocoumon']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity2067 :: ('MESH:D014812', 'Chemical') :: ['vitamin K']

entities_list: @entity3926 :: ('MESH:C554682', 'Chemical') :: ['dabigatran']

entities_list: @entity3925 :: ('MESH:C503223', 'Chemical') :: ['rivaroxaban']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Paroxysmal AF', 'AF']

answer: @entity955 :: (MESH:D001281,Disease) :: ['AF']


abstract: @entity43 (OGCT) and sex @entity4097 (OSCST), each of which account for less than 5% of all @entity43 , are much less common than @entity43 . In young @entity1 suspected of having an OGCT, laparotomy is initially indicated for both diagnosis and treatment. For most @entity1 , unilateral salpingo-oophorectomy with preservation of the contralateral ovary and the uterus is appropriate. The basis for this surgical approach is retrospective studies that show an equivalent cure rate for @entity1 who undergo unilateral or bilateral adnexectomy. No prospective studies have compared unilateral with bilateral adnexectomy. @entity5 is also important to determine the extent of disease, to determine prognosis, and to guide postoperative management. If @entity3 is encountered during initial surgery for OGCT, the same principles of cytoreductive surgery that have been applied to surgically manage advanced @entity43 are recommended, with resection of as much @entity5 as is technically feasible and safe. For all OGCT @entity1 except those with well-documented stage IA grade 1 pure immature @entity44 or stage IA pure @entity5000 , postoperative chemotherapy is indicated. The current recommended regimen for OGCT is @entity1732 , @entity2879 , and @entity900 --a combination that appears to result in at least a 95% cure rate for stage I disease and at least a 75% cure rate for @entity5 . For @entity1 with @entity3 , chemotherapy, which has the advantage of preserving fertility in the majority of @entity1 , has supplanted radiotherapy as standard treatment. For @entity1 with OSCST, no standard therapy exists. Surgery alone is currently acceptable treatment for all @entity1 with OSCST except those who have @entity3 or @entity10693 with poor differentiation or heterologous elements. Currently, @entity902 -based combination chemotherapy is favored for these latter @entity1 , but the activity of such regimens appears only modest.

title: Management of early @entity43 : germ cell and sex XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Malignant ovarian germ cell tumors', 'epithelial ovarian cancer', 'ovarian malignancies']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity10693 :: ('MESH:D018310', 'Disease') :: ['Sertoli-Leydig cell tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Surgical staging', 'advanced-stage disease']

entities_list: @entity5000 :: ('MESH:D004407', 'Disease') :: ['dysgerminoma']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic dysgerminoma', 'metastatic disease']

entities_list: @entity4097 :: ('MESH:D013120', 'Disease') :: ['cord-stromal tumors']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

answer: @entity4097 :: (MESH:D013120,Disease) :: ['cord-stromal tumors']


abstract: Previous work has demonstrated that @entity1949 ( @entity1949 ) potentiates @entity2072 -induced genital reflexes in male @entity35 . To examine the possibility that this effect might involve alterations in binding to the @entity23491 ( @entity23491 ), we examined [3H] WIN 35,248 binding in brain after 96 h of @entity1949 . No changes were found in any of the 11 brain regions examined. Since we had previously identified changes in D2 receptor binding after @entity1949 , we next examined the effects of DA receptor subtype antagonists on @entity2072 -induced reflexes in sleep-deprived @entity35 . Separate groups of @entity1949 @entity35 received saline, @entity1767 (0.4, 0.8 or 1.6 mg/kg), @entity10095 (0.25, 0.5, 1 mg/kg) or @entity3216 (50, 100, 200 mg/kg) 60 min prior to acute @entity2072 (7 mg/kg). In saline pretreated @entity35 , @entity2072 -induced penile erection (PE) in 100% of SD @entity35 . This percentage was not significantly reduced by @entity1767 at any dose, but was significantly reduced in @entity35 pretreated with @entity10095 (1 mg/kg) or @entity3216 (100 or 200 mg/kg). In addition, acute @entity2072 -induced ejaculation in 80% of SD @entity35 . This effect was not affected by @entity1767 at any dose, but was significantly reduced by all doses of @entity10095 and by the 200 mg/kg dose of @entity3216 . These results suggest that the potentiating effects of @entity2072 on penile erection and ejaculation are likely due to @entity1949 -induced changes in DA postsynaptic receptor sensitivity rather than alterations in @entity23491 . They further suggest that both D1 and D2 receptors may play a role in these effects.

title: Involvement of dopamine receptors in @entity2072 -induced genital reflexes after XXXX .

entities_list: @entity1949 :: ('MESH:D012892', 'Disease') :: ['paradoxical sleep deprivation', 'PSD']

entities_list: @entity3216 :: ('MESH:D013469', 'Chemical') :: ['sulpiride']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

answer: @entity1949 :: (MESH:D012892,Disease) :: ['paradoxical sleep deprivation']


abstract: In this study the early and late results of surgical reconstruction for @entity2792 caused by @entity5323 are evaluated in 53 @entity1 treated between 1962 and 1983. There were 40 female and 13 male @entity1 . The mean blood pressure was 208/126 mm Hg before medical therapy and 171/109 mm Hg thereafter. @entity2791 were present in 12 @entity1 . In situ revascularization was used in 26 @entity1 and extracorporeal surgery to repair branch artery lesions was performed in 27 @entity1 . Surgical therapy reduced the blood pressure to normal levels with minimal antihypertensive medications. This effect was already apparent 6 to 12 months after operation (mean blood pressure level of 140/90 mm Hg) and it was maintained during a mean follow-up period of 8.4 years (range 1 to 20 years) (mean blood pressure level of 134/85 mm Hg). At 6 to 12 months after operation, 79% of the @entity1 were classified as either cured or improved. At this time the results did not appear to have been influenced by the preoperative duration of @entity101 , nor by manifestations of @entity4288 ( @entity4288 ) as found in 10 @entity1 , or by the surgical technique applied. But at the end of the long-term follow-up period (mean 8.3 years) the beneficial response rate of 87% appeared to have been adversely influenced by the presence of preoperative @entity4288 , since beneficial response rates were 93% for those without and 67% for those with @entity4288 (p = 0.17). We conclude that renal revascularization is effective both early and late for the treatment of @entity2792 caused by @entity5323 and that complex @entity455 can be treated effectively with extracorporeal repair.

title: Long-term results of in situ and extracorporeal surgery for XXXX caused by @entity5323 .

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['renovascular obstruction']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2792 :: ('MESH:D006978', 'Disease') :: ['renovascular hypertension']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['Bilateral renal artery stenoses']

entities_list: @entity5323 :: ('MESH:D009221', 'Disease') :: ['fibrodysplasia']

entities_list: @entity4288 :: ('MESH:D001161', 'Disease') :: ['extrarenal arteriosclerosis', 'ERA']

answer: @entity2792 :: (MESH:D006978,Disease) :: ['renovascular hypertension']


abstract: BACKGROUND: These analyses compared efficacy of @entity1037 in @entity1 with @entity162 with or without mixed features, as defined in the @entity4987 . METHODS: Pooled data from 3 placebo-controlled @entity1037 studies in @entity1 having @entity162 with @entity162 /mixed episode were analyzed (N=228 @entity1037 ; N=219 placebo). @entity1 were categorized for mixed features by number of concurrent @entity308 symptoms at baseline (0, 1, and 2 [category A; without mixed features], and >= 3 [category B; with mixed features]), as determined by HAM-D17 item score >= 1. @entity308 corresponded to 6 HAM-D17 items in the @entity4987 definition of @entity162 with mixed features. Primary efficacy was evaluated by changes in the baseline-to-3-week YMRS total score. RESULTS: @entity1 were categorized into A (N=322; 72.0%) or B (N=125; 28.0%). Mean baseline YMRS total scores were 28.1 in category A and 27.8 in category B. Least-squares mean change of YMRS total scores in categories A and B ( @entity1037 versus placebo) were -11.78 versus -6.86 and -13.21 versus -4.72, respectively. @entity1 in the @entity1037 - compared with placebo-group experienced a greater decrease in YMRS total score for both categories (p<0.001). An interaction between mixed features and treatment was seen in YMRS change at a 0.3 significance level (p=0.175). LIMITATIONS: The results are from post-hoc analyses. CONCLUSIONS: @entity1037 was efficacious in the treatment of @entity162 mania, in @entity1 both with and without mixed features, defined by @entity4987 ; however, greater efficacy was observed in @entity1 with mixed features having more severe @entity308 symptoms.

title: Efficacy of XXXX in the treatment of @entity162 with mixed features defined by @entity4987 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['manic', 'bipolar I', 'bipolar mania', 'bipolar I disorder', 'manic episode']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive', 'Depressive symptoms']

entities_list: @entity1037 :: ('MESH:C076029', 'Chemical') :: ['Olanzapine', 'olanzapine']

answer: @entity1037 :: (MESH:C076029,Chemical) :: ['olanzapine']


abstract: Via a multicentre study coordinated by the EPM research group carried out in 216 wards in a total of 56 hospitals, old @entity1 homes and geriatric departments, it was possible to quantify exposure to @entity1 handling (classified in 4 classes: 0-1.5 negligible, 1.51-5 slight to average, 5.01-10 average to high, > 10 elevated), and at the same time identify the damage to the lumbosacral spine thus caused. Both assessment of exposure and identification of health impairment were carried out using homogeneous methods. Subjects with work seniority in the job of less than 6 months and subjects who had been transferred because of back trouble were excluded from the study. It was therefore possible to carry out two types of study to assess the association between exposure and impairment. In study A, covering 3021 subjects, an analysis was performed of the association between exposure index, positive response to the anamnestic threshold for @entity74 and @entity1643 using the method of logistic analysis to obtain the prevalence odds ratios. In study B, covering 418 subjects, the analysis of association was performed on the incidence rates of episodes of @entity1643 and pharmacologically controlled @entity1643 , assuming that exposure in the wards had remained constant. The technique used was Poisson regression, thereby calculating the relative incidence rate ratios. Both for PORs and IRRs the reference group consisted of the exposure class judged as negligible (exposure index 0-1.5). The results showed that the PORs calculated for positive lumbar threshold were significant for increasing exposure classes with a positive trend for the second and third exposure class but not for the last, presumably due to a healthy worker selection effect. Neither in Study A nor in Study B were any associations observed between exposure and @entity1643 occurring in the previous 12 months: this may be due to the fact that the impairment indicator does not appear to be appropriate in terms of latency period. A different result was obtained in Study B which showed a good association between exposure and incidence rates of episodes of @entity1643 and pharmacologically controlled @entity1643 according to department. The IRRs showed a positive trend both for acute episodes ( @entity12623 : 1.932, 2.439, 2.847) and for acute plus pharmacologically controlled acute episodes (1.798, 1.830, 4.523). On the basis of these results, even with the caution required for the reasons explained in the text, it seems to be possible to identify three grades of exposure which correspond to increasing probability of impairment of the lumbosacral region of the spine: the first where risk seems negligible corresponds to an exposure level between 0 and 1.5. The second, where the episodes of @entity1643 may occur with an incidence 3.8 times greater, corresponds to an exposure level between 1.51 and 5, and the third corresponds to exposure levels exceeding 5, where the episodes of @entity1643 may occur with an incidence up to 5.6 times greater than expected.

title: [The application of a synthetic index of exposure in the manual lifting of XXXX : the initial validation experiences].

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'peoples']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'acute low back pain']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['lumbosacral disorders']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: @entity3031 is a rare but potentially devastating injury. Quoted rates of associated vascular compromise vary dramatically between 3.3% and 64%, and the best approach to investigate and diagnose such an injury remains controversial. We aim to evaluate our own 4-year experience of @entity3031 and @entity1317 as a UK @entity130 Centre and vascular hub. METHODS: @entity3031 was defined as disruption of at least two major stabilising ligaments of the knee and gross instability requiring an operation. @entity1 were identified from the Department of @entity130 and Orthopaedics @entity1 database across a 4 year period from 2010 to 2014. Electronic @entity1 records, imaging and hard notes were retrieved and reviewed retrospectively and relevant information recorded. RESULTS: Twenty-five cases of @entity3031 were identified. Male to female ratio was 11.5:1 with a mean age of 33 years (range 17-71). One @entity1 had a @entity1317 which ultimately required a femoro-popliteal bypass graft. Twenty-four @entity1 had documented examination findings pertaining to the vascular status of the limb. Seventeen @entity1 had specific reference to the presence or absence of pedal pulses. The remaining seven cases were documented as either "warm well perfused" or "neurovascularly in-tact". Nine @entity1 were discharged directly from the emergency department with outpatient follow up. All admitted cases had documented vascular examination findings the following day. Two @entity1 had additional adjunctive non-invasive investigations. No @entity1 were examined with duplex ultrasound, although two @entity1 had pulses confirmed with hand-held doppler ultrasound. Three @entity1 had an angiogram. Four cases have a documented discussion with or review from a vascular surgeon. DISCUSSION AND CONCLUSIONS: Our rates of @entity1317 are in line with the most recent and largest study to date. Non-invasive investigation and selective angiography has been safe in identifying significant vascular compromise, however, there is inconsistency in management pathways, and too much reassurance attributed to the presence of pedal pulses on initial examination. Safety and consistency could be improved with the introduction of a formalised evidence-based protocol for the initial evaluation of @entity3031 and @entity1317 .

title: XXXX and @entity1317 : 4 year experience at a UK @entity130 Centre and vascular hub.

entities_list: @entity3031 :: ('MESH:D031221', 'Disease') :: ['Knee dislocation', 'knee dislocation']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Major Trauma', 'Trauma']

answer: @entity3031 :: (MESH:D031221,Disease) :: ['Knee dislocation']


abstract: Six subjects wore intraoral devices carrying @entity291 enamel blocks covered with a layer of @entity6586 . They swished solutions of 5% @entity413 or @entity7969 , or sols or gels of 3, 5, 10, 15, or 20% gelatinized @entity3505 starch in the mouth for 3 X 1 min. @entity3760 was measured after 45 min by determining the change in @entity6893 permeability (delta Ip) of the enamel. Spittings of the administered materials and samples of saliva, taken at intervals during the test, were analyzed for @entity7969 , and the time of clearance was calculated. @entity3760 was greatest for @entity413 followed by @entity7969 , the starch gels, and the sols. The latter gave close to zero scores. The salivary clearance time increased with increase in concentration of the starch. Although the starch was hydrolyzed rapidly in the mouth, its oral retentiveness was greater than that of the @entity7969 rinse. @entity3760 was closely correlated with the final pH of the @entity6586 cell layer. The data indicate that the starch in baked or cooked foods may have a significant demineralization potential and that it enhances oral retentiveness.

title: @entity3760 potential of different concentrations of gelatinized XXXX starch.

entities_list: @entity6586 :: ('1309', 'Species') :: ['Streptococcus mutans', 'S. mutans']

entities_list: @entity3760 :: ('MESH:D017001', 'Disease') :: ['Demineralization']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity3505 :: (4565,Species) :: ['wheat']


abstract: OBJECTIVE: The aim of the present study was to determine the accuracy of clinical diagnoses of @entity303 in a large group of @entity1 evaluated in a multicenter, university-based, @entity195 diagnostic and treatment program. METHOD: Clinical diagnoses and neuropathological results from seven collaborating @entity195 research centers were compared for 196 cases of @entity303 . RESULTS: When diagnoses of probable @entity195 , possible @entity195 , and @entity195 plus another condition were combined, 163 (83%) of the @entity1 were clinically regarded as likely to have had @entity195 . Of those @entity1 , 134 (82%) were found to have neuropathological changes diagnostic of @entity195 or @entity195 plus another condition. A total of 116 @entity1 were diagnosed as having probable @entity195 ; 100 (86%) of those were found to have pathological diagnoses of @entity195 or @entity195 plus another condition. @entity385 were found in 17% of the @entity1 clinically diagnosed with probable @entity195 . Lewy bodies with variable @entity195 -type pathological changes were found in 7% of the @entity1 with clinical diagnoses of probable @entity195 . Conversely, significant @entity195 -type pathological changes were found in 55% of the @entity1 clinically diagnosed as having @entity1294 . CONCLUSIONS: Clinicians accurately predict @entity195 in a high proportion of cases of @entity303 but may not predict cerebrovascular pathology and Lewy bodies in some @entity1 with apparent clinical @entity195 and may often fail to predict @entity195 -type pathological findings in @entity1 with apparent @entity1294 . With the emergence of effective treatments for @entity195 , there is an increasing need to optimize methods for ante-mortem diagnosis of @entity303 .

title: Multicenter clinicopathological correlation in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease-type neuropathological findings", "Alzheimer's disease"]

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['Cerebral infarcts']

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementia']


abstract: BACKGROUND: @entity1 with @entity1082 )-positive @entity957 (SCC) have a better survival than with HPV-negative oropharyngeal SCC. An @entity419 positron emission tomography-CT ( @entity419 -PET-CT) may also provide prognostic information. We evaluated glycolytic characteristics in HPV-negative and HPV-positive oropharyngeal SCC. METHODS: Forty-four @entity1 underwent pretreatment (18) F-FDG-PET-CT. Standardized uptake values (SUVs) and metabolic active @entity5 volumes (MATVs) were determined for @entity5 . HPV status was determined with @entity986 immunostaining, followed by high-risk HPV DNA detection on the positive cases. RESULTS: Twenty-seven @entity1 were HPV-positive (61.4%). Median MATV was 2.8 mL (range = 1.6-5.1 mL) for HPV-positive and 6.0 mL (range = 4.4-18.7 mL) for @entity5 (p < .001). SUV values are volume dependent (partial volume effect), therefore, MATV was included as covariate in multivariate analysis. In this multivariate analysis, the maximum SUV in @entity5 was 3.9 units lower than in @entity5 (p = .01). CONCLUSION: The @entity419 -PET-CT parameters are lower in HPV-positive than in HPV-negative @entity1 . Low pretreatment SUV values in HPV-positive oropharyngeal SCC may be at least partly explained by HPV-induced @entity5 changes.    2015 Wiley Periodicals, Inc. Head Neck, 2015.

title: Interaction of quantitative @entity419 -PET-CT imaging parameters and XXXX status in @entity957 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18) F-fluorodeoxyglucose', '(18) F-FDG']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'HPV-negative tumors', 'HPV-positive tumors', 'primary tumors']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['oropharyngeal squamous cell carcinoma']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus']


abstract: BACKGROUND AND PURPOSE: Early reocclusion of intracranial arteries can lead to poor clinical outcome. We report reocclusion detection after endovascular clot aspiration, followed by administration of @entity1427 -IIIa antagonist under continuous ultrasound monitoring. CASE DESCRIPTION: A 73-year-old @entity1 developed the @entity2500 with NIHSS 17 points, 6 days after aortic valve replacement. Recanalization was achieved with Penumbra    system and reocclusion was detected with transcranial Doppler (TCD) 30 minutes postcompletion of intra-arterial procedure. Proximal recanalization was achieved with the second @entity715 aspiration while M2 MCA occlusion persisted beyond the reach of the device. Intravenous abciximab was administered under continuous TCD monitoring. Recanalization with Thrombolysis in @entity2806 (TIBI) flow grade 4 was observed at 60 minutes postintervention accompanied with clinical recovery to NIHSS 3 points. Abciximab was given for 12 hours with no hemorrhagic transformation on repeat CT scan. @entity1 was discharged home with mild left pronator drift and facial droop, and his modified ranking score was 1 at 6-week follow-up visit. CONCLUSIONS: Early arterial reocclusion can occur after successful @entity715 aspiration while @entity1427 -IIIa antagonist administration may lead to subsequent recanalization of persisting distal occlusions not amenable to mechanical removal.

title: Arterial reocclusion and persistent distal occlusion after XXXX aspiration.

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['Brain Ischemia']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['right middle cerebral artery (MCA) occlusion']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombus']


abstract: BACKGROUND: While using echocardiography to guide endomyocardial biopsy (EMB), the authors have identified acute intracardiac @entity715 formation related to the procedure, a hitherto unreported complication. The aims of this study were to identify the procedural details and characteristics of @entity1 who developed this complication between June 2008 and April 2009 and to describe their outcomes and management. METHODS: In total, 415 right ventricular biopsies were performed during this period. Of these, 189 were echocardiographically guided, and the medical records of these @entity1 were reviewed retrospectively. RESULTS: There were eight cases of acute right-sided intracardiac @entity715 formation in seven @entity1 (about 4% of the echocardiographically guided group) at the time of biopsy. The indications for EMB were heart transplant surveillance in six @entity1 and suspected @entity299 in one @entity1 . Three cases were performed via a transjugular approach and four via a femoral approach. Four @entity1 had histories of prior @entity715 , and one @entity1 had a defined clotting diathesis. Management included either immediate @entity715 aspiration or postprocedural anticoagulation. There were no overt occurrences of @entity1151 . CONCLUSIONS: Acute @entity715 formation is a complication of EMB. If this complication is unrecognized, and therefore untreated, @entity1151 may result. This may have important clinical implications in @entity1 undergoing routine repeated surveillance EMB after cardiac transplantation. The authors recommend performing transthoracic echocardiography during EMB, particularly in @entity1 with histories of @entity715 , because this group of @entity1 may be at increased risk for procedural @entity715 , and procedural echocardiography permits early recognition and treatment of this complication.

title: Acute XXXX formation as a complication of right ventricular biopsy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses', 'thrombus', 'thrombosis']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary thromboembolism']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac amyloidosis']

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombus']


abstract: BACKGROUND: No unified method exists to effectively predict and monitor progression of @entity120 ( @entity120 ). We assessed the longitudinal relationship between a novel marker of cardiopulmonary reserve and established prognostic surrogate markers in @entity1 with @entity358 . METHODS AND RESULTS: Twenty @entity1 with confirmed (n   =   14) or at high risk (n   =   6) for @entity120 underwent cardiovascular magnetic resonance (CMR) at baseline and after ~6  months of guideline-appropriate management. Ten @entity120 @entity1 underwent RHC within 48  h of each CMR. RHC (mean pulmonary arterial pressure, @entity7215 ; pulmonary vascular resistance index, PVRI; cardiac index, CI) and phase-contrast CMR (mean pulmonary arterial blood flow velocity, meanPAvel) measurements were taken at rest and during continuous @entity859 infusion (70/140/210 mcg/kg/min). Initial meanPAvel's (rest and hyperemic) were correlated with validated surrogate prognostic parameters (CMR: RV ejection fraction, RVEF; RV end systolic volume indexed, RVESVI; RHC: PVRI, CI; biomarker: NT-pro brain natriuretic peptide, NTpBNP; clinical: 6-min walk distance, 6MWD), a measure of pulmonary arterial stiffness (elastic modulus) and volumetric estimation of RV ventriculoarterial (VA) coupling. Changes in meanPAvel's were correlated with changes in comparator parameters over time. At initial assessment, meanPAvel at rest correlated significantly with PVRI (inversely), CI (positively) and elastic modulus (inversely) (R (2)   >   0.37,P   <   0.05 for all), whereas meanPAvel at peak @entity450 correlated significantly with PVRI, RVEF, RVESVI, 6MWD, elastic modulus and VA coupling (R (2)   >   0.30,P   <   0.05 for all). Neither resting or @entity450 -derived meanPAvel correlated with NTpBNP levels. Initial meanPAvel at rest correlated significantly with RVEF, RVESVI, CI and VA coupling at follow up assessment (R (2)   >   0.2,P   <   0.05 for all) and initial meanPAvel at peak @entity450 correlated with RVEF, RVESVI, PVRI and VA coupling (R (2)   >   0.37,P   <   0.05 for all). Change in meanPAvel at rest over time did not show statistically significant correlation with change in prognostic parameters, while change in meanPAvel at peak @entity450 did show a significant relationship with   RVEF,   RVESVI,   NTpBNP and   CI (R (2)   >   0.24,P   <   0.05 for all). CONCLUSION: MeanPAvel during peak @entity450 correlated with invasive, non-invasive and clinical prognostic parameters at different time points. Further studies with predefined clinical endpoints are required to evaluated if this novel tool is a marker of disease progression in @entity1 with @entity358 .

title: The predictive capabilities of a novel cardiovascular magnetic resonance derived marker of cardiopulmonary reserve on established prognostic surrogate markers in XXXX with @entity358 : results of a longitudinal pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['PAH', 'pulmonary arterial hypertension']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary vascular disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: The therapeutic options for relapsed or refractory @entity7801 -ITD positive @entity3052 are limited, particularly in case of a prior allogenic @entity8 ( @entity8 ) or poor performance status. The clinical value of a targeted intervention using the @entity7801 -ITD-specific inhibitor @entity2857 in this situation is largely unknown. @entity1 AND METHODS: Between 2007 and 2010 eight @entity1 (4 @entity1 , 4 @entity1 ; age 40-75 years) with relapsed or refractory @entity7801 -ITD positive @entity3052 ( @entity3052 ) before (n=4) and after allogenic @entity8 (n=5) were treated off-label with @entity2857 . RESULTS: All @entity1 showed rapid hematological responses. There were three complete molecular remissions when @entity2857 was given after allogenic @entity8 . Two of them are ongoing for 12 and 15 months, respectively. Long-term remissions after prior allogenic @entity8 were associated with the re-establishment of a chronic graft versus host reaction. Side effects could be controlled by dose reduction. CONCLUSION: @entity2857 is apparently an effective treatment alternative for @entity1 with relapsed or refractory @entity7801 -ITD positive @entity3052 . In the context of a prior allogenic @entity8 it may have curative potential via inducing a synergism between targeted inhibition of @entity7801 -ITD and anti- @entity1778 immunity.

title: [ @entity2857 in relapsed and refractory XXXX -ITD positive @entity3052 : a novel treatment option].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation']

entities_list: @entity2857 :: ('MESH:C471405', 'Chemical') :: ['sorafenib', 'Sorafenib']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

answer: @entity7801 :: (2322,Gene) :: ['FLT3']


abstract: Two postmilking teat dips were tested for efficacy against @entity794 and @entity5967 using experimental challenge procedures recommended by the National @entity1271 Council. Both dips contained @entity19946 as the primary germicidal agent and @entity880 or @entity19947 as the @entity19946 activator. The dip activated with @entity19947 significantly reduced new IMI by Staph. aureus and Strep. agalactiae. The IMI rate was reduced 68.7% for Staph. aureus and 56.4% for Strep. agalactiae. The dip activated with @entity880 significantly reduced new Staph. aureus IMI by 69.3% but did not significantly reduce new Strep. agalactiae IMI (35.2% reduction) through the full 11-wk study period. Teat @entity272 did not change from pretrial status after using either teat dip during the study.

title: Efficacy of two barrier teat dips containing @entity19946 germicides against experimental challenge with XXXX and @entity5967 .

entities_list: @entity5967 :: ('1311', 'Species') :: ['Streptococcus agalactiae']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity19946 :: ('MESH:C063160', 'Chemical') :: ['chlorous acid']

entities_list: @entity19947 :: ('MESH:C037938', 'Chemical') :: ['mandelic acid']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin condition']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

answer: @entity794 :: (1280,Species) :: ['Staphylococcus aureus']


abstract: Orbital fibroblasts in culture display phenotypic attributes that distinguish them from fibroblasts derived from other anatomical regions. The current studies were conducted to define potential cellular heterogeneity among orbital fibroblasts with regard to 1) differential expression of @entity5399 , a 25-kilodalton glycoprotein associated with cell signaling; 2) cells undergoing a change in shape in response to @entity1421 ( @entity1421 ); and 3) differences in morphology and @entity5399 expression between single cell-derived clonal fibroblast strains. On the basis of flow cytometric analysis using an anti- @entity5399 monoclonal antibody, 65% of intact orbital fibroblasts expressed surface @entity5399 (n = 5; range, 54-71%). In contrast, greater than 95% of the fibroblasts present in the five dermal strains tested were @entity5399 positive. A total of six strains of orbital fibroblasts were assessed for their shape change response to a 4-h treatment with @entity1421 (100 nmol/L). A mean of 37% of the fibroblasts present in each culture responded to @entity1421 (range, 22-50%). In contrast, only 1% of dermal fibroblasts exhibited any change in morphology. Three separate clones were generated from a single parent strain of Graves' orbital fibroblasts. These clones consisted of homogeneous appearing cells; however, substantial clone to clone differences in morphology were stably expressed for several population doublings. @entity5399 was expressed uniformly in cells of two clones, whereas the third was @entity5399 negative. Factor VIII and smooth muscle-specific alpha-actin were undetectable in any of the orbital or dermal cultures examined. Thus, @entity5399 expression is uniform in fibroblasts from certain anatomical regions such as the skin and heterogeneous in cells derived from @entity1 lung and orbit. These findings suggest that @entity1 orbital connective tissue may have a complexity not previously appreciated.

title: Evidence for cellular heterogeneity in primary cultures of XXXX orbital fibroblasts.

entities_list: @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2', 'PGE2']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity981 ( @entity981 ) in childhood is a serious disease that can affect growth and the attainment of maximal peak bone mass. The latter has recently been recognized as a risk factor for the development of @entity170 later in life. To determine long-term effects of the disease itself and its treatment, we assessed the bone status of a group of long-term survivors of childhood @entity981 , all treated with high doses of @entity230 ( @entity619 ) and @entity1499 and without cranial irradiation. All 21 subjects enrolled in this cross-sectional study were diagnosed to have non-high-risk precursors @entity981 (12 @entity1 and 9 @entity1 , mean age 16.5 yr, range 12.2-25.4 yr). Standard deviation (SD) scores were calculated using a tibial ultrasound device and spinal dual-energy X-ray absorptiometry (DXA) device as bone assessment techniques. SD scores of those two different bone assessment techniques were compared. The mean SOS (speed of sound) SD scores ( @entity214 ) of the tibia (mean 0.26, standard deviation [sd] 1.00) were not significantly different from our reference value of 0. There was no significant difference between the SOS @entity214 in @entity1 and @entity1 . With DXA, no significant difference was seen between the mean BMD @entity214 and the reference data and no significant difference in BMD between @entity1 and @entity1 was found. The individual mean @entity214 for bone mineral density (BMD) of lumbar spine are 0.24 (sd 1.02), total body 0.17 (sd 1.00), and apparent BMD (BMAD) 0.07 (sd 1.09). Spearman's correlation between mean SOS @entity214 and mean BMD of lumbar spine was 0.47, mean SOS @entity214 and mean BMAD @entity214 was 0.43, and mean SOS @entity214 and mean BMD of total body was 0.49. These correlations were significant at the 0.05 level (two tailed). Despite high-dose @entity619 and @entity1499 used for treatment of these @entity1 with @entity981 , no long-term side effects on the bone mineral status of the subjects, measured with DXA or tibial ultrasonometry, could be determined.

title: Bone mineral assessment with tibial ultrasonometry and dual-energy X-ray absorptiometry in long-term survivors of XXXX in childhood.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['Acute lymphoblastic leukemia', 'ALL', 'acute lymphoblastic leukemia']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']


abstract: Enhanced External Counterpulsation (EECP) has emerged as a promising non-invasive modality not only for @entity1 with @entity951 ( @entity951 ) but also for @entity1 with @entity712 . To our knowledge, no published data exists in Pakistan about the benefits of EECP. We report on a case series of 16 consecutive @entity1 undergoing EECP. All @entity1 were either deemed not to be candidates for revascularization or had failed revascularization with @entity951 on optimal medical therapy. Data was collected regarding the coronary anatomy, clinical presentation, Pre and Post EECP @entity65 ( @entity65 ) class, @entity1507 use and 6-min walk test. @entity1 with severe @entity1095 and @entity943 were excluded. The mean age was 56 +/- 11.1 years. Eight @entity1 had 3-vessel disease. 4 post-CABG with occluded grafts and the rest with variable combination of @entity301 . Seven (44%) @entity1 had @entity1459 and 9 (56%) had @entity5749 . The mean 6 min walk distance before EECP was 295 +/- 148.60 meters and after EECP was 360 +/- 102.12 meters (p = 0.013). The @entity65 class before and after EECP also showed significant improvement (p = 0.017). Sublingual @entity12118 use also showed a positive trend after EECP. EECP was noted to be a safe and effective modality for @entity1 with @entity951 with statistically significant improvement in measures of quality of life.

title: Enhanced external counter pulsation (EECP) for XXXX ( @entity951 ); results from a first case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity12118 :: ('CHEBI:28787', 'Chemical') :: ['nitroglycerine']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary disease']

entities_list: @entity5749 :: ('MESH:D060050', 'Disease') :: ['Stable Angina']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity1459 :: ('MESH:D000789', 'Disease') :: ['Unstable Angina']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['RAP', 'refractory angina pectoris']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CCS', 'Canadian Cardiovascular Society']

answer: @entity951 :: (MESH:D000787,Disease) :: ['refractory angina pectoris']


abstract: AIM: The benefit of coarctation repair on the resolution of systolic @entity101 in adults has been questioned. METHODS: Between March 1997 and July 2009, 65 consecutive adult @entity1 (>=  16 years) underwent repair of @entity1498 . There were 40 @entity1 (65%) and 25 @entity1 (35%) with a mean age of 22.3    4.8 years (range, 16 to 34 years). All @entity1 had critical @entity101 ( @entity13519 >=  140 mmHg). @entity13519 ranged from 140 to 205 mmHg, with a mean of 163.5    17.6 mmHg. The mean diastolic BP was 95.1    18.3 mmHg (range, 70 to 120 mmHg). Most @entity1 (41/65, 74%) were on a regimen of at least one antihypertensive drug. RESULTS: The @entity1 were followed up after coarctation repair for 2 to 144 months (mean, 68    39 months). There was no death. No other major complications occurred. There have been no repeat interventions during follow-up. Four @entity1 were lost to follow-up. Of the 61 @entity1 with preoperative @entity101 , 53 (87%) were normotensive ( @entity13519 <140 mmHg) at the most recent follow-up visit. The remaining eight @entity1 showed substantial improvement versus the preoperative status. The mean @entity13519 after operation was 122.5    12.4 mmHg. Mean diastolic blood pressure was 79.5    11.6 mmHg. Forty-one (67%) @entity1 were taking no medication at the last follow-up. CONCLUSION: Surgical repair of @entity1498 in adults can lead to regression of systolic @entity101 and a decreased requirement for antihypertensive medication.

title: @entity101 in adult after operation of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of the aorta', 'aortic coarctation']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'systolic blood hypertension']

answer: @entity1498 :: (MESH:D001017,Disease) :: ['aortic coarctation']


abstract: BACKGROUND: The present study was designed to evaluate which arterial stiffness parameter - AASI or the home arterial stiffness index (HASI) - correlates best with vascular, cardiac and @entity8 in @entity101 individuals. METHODS: A cross-sectional study was carried out involving 258 @entity101 @entity1 . AASI and HASI were defined as the 1-regression slope of diastolic over systolic blood pressure readings obtained from 24-hour recordings and home blood pressure over 6 days. @entity8 was evaluated by glomerular filtration rate (GFR) and microalbuminuria; vascular damage by carotid @entity121 ( @entity121 ), pulse wave velocity ( @entity122 ) and ankle/brachial index (ABI); and left @entity123 by the Cornell voltage-duration product (VDP) and the Novacode index. RESULTS: AASI and HASI were not correlated with microalbuminuria, however AASI and HASI- blood pressure variability ratio (BPVR) showed negative correlation with GRF. The Cornell PDV was positively correlated with AASI- BPVR-Sleep (r = 0.15, p < 0.05) and the left ventricular mass index with HASI-BPVR (r = 0.19, p < 0.01). Carotid @entity121 and @entity122 were positively correlated with all the parameters except the HASI, while ABI was negatively correlated with AASI and Awake-AASI. After adjusting for age, gender and 24 hours heart rate, statistical significance remains of the @entity121 with AASI, Awake AASI and AASI-BPVR. @entity122 with the AASI, Awake-AASI and Sleep-AASI. ABI with AASI and Awake-AASI. Odd Ratio to presence target organ damage was for AASI: 10.47(IC95% 1.29 to 65.34), Awake-AASI: 8.85(IC95% 1.10 to 71.04), Sleep-AASI: 2.19(IC95% 1.10 to 4.38) and AASI-BPVR-night: 4.09 (IC95% 1.12 to 14.92). CONCLUSIONS: After adjusting for age, gender and 24-hour heart, the variables that best associated with the variability of @entity121 , @entity122 and ABI were AASI and Awake-AASI, and with GFR was HASI-BPVR.

title: Ambulatory arterial stiffness indices and target organ damage in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal damage', 'renal damage']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity123 :: ('MESH:D024741', 'Disease') :: ['ventricular hypertrophy']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: OBJECTIVES: The purpose of this study was to examine the association between lower @entity159 ( @entity159 ), as ascertained by years of education, and outcomes in @entity1 with acute @entity583 ( @entity583 ). BACKGROUND: Previous studies have shown an inverse relationship between @entity159 and @entity301 and mortality. Whether a similar association between @entity159 and mortality exists in @entity583 @entity1 is unknown. METHODS: We evaluated 11,326 @entity1 with @entity583 in the GUSTO-III (Global Use of Strategies to Open Occluded Coronary Arteries) trial study from countries that enrolled >500 @entity1 . We evaluated clinical outcomes (adjusted using multivariate regression analysis) according to the number of years of education completed. RESULTS: One-year mortality was inversely related to years of education and was 5-fold higher in @entity1 with <8 years compared with those with >16 years of education (17.5% vs. 3.5%, p < 0.0001). The strength of the relationship between education and mortality varied among different countries. Nonetheless, years of education remained an independent correlate of mortality at day 7 (hazard ratio per year of increase in education: 0.86; 95% confidence interval: 0.83 to 0.88) and also between day 8 and 1 year (hazard ratio per year of increase in education: 0.96; 95% confidence interval: 0.94 to 0.98), even after adjustment for baseline characteristics and country of enrollment. CONCLUSIONS: When the number of years of education was used as a measure of @entity159 , there was an inverse relationship such that significantly higher short-term and 1-year mortality existed beyond that accounted for by baseline clinical variables and country of enrollment. Future studies should account for and investigate the mechanisms underlying this link between @entity159 and @entity65 outcomes.

title: Association of mortality with years of education in @entity1 with XXXX treated with fibrinolysis.

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-segment elevation myocardial infarction']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['SES', 'socioeconomic status']

answer: @entity583 :: (MESH:D009203,Disease) :: ['ST-segment elevation myocardial infarction']


abstract: The records of sixty @entity1 who had a @entity320 of the foot or ankle were reviewed retrospectively to determine the clinical features, prognostic factors, and distinguishing characteristics. Fifty-seven @entity1 were white and three were black. There were forty-two @entity1 and eighteen @entity1 (a female-to-male ratio of 2.3 to 1). The mean age at the time of presentation was fifty-seven years (range, twenty-two to eighty-three years). The most common site of involvement was the plantar aspect of the foot. The mean duration of follow-up was forty-five months (range, three to 144 months). Kaplan-Meier life-table analysis revealed an over-all five-year survival rate of 63 per cent and an over-all ten-year survival rate of 51 per cent. The mean duration of survival for the @entity1 who had a @entity75 was significantly shorter than that for the @entity1 who had a lesion at another site on the dorsal aspect of the foot or on the ankle (forty-seven compared with seventy-two months) (p = 0.02). The mean depth of the lesion, according to the criteria of Breslow, was 3.03 millimeters, and the mean level, according to the classification of Clark et al., was IV. According to the classification of the American Joint Commission on @entity5 , forty-three @entity1 had stage-I or II (local) disease, thirteen had @entity5 (nodal or in-transit disease, defined as cutaneous or subcutaneous @entity3 more than two centimeters from the primary @entity5 but not beyond the regional lymph nodes), and four had stage-IV disease (distant visceral @entity3 ) at the time of presentation. Lesions at plantar and subungual sites were also associated with a higher prevalence of clinical misdiagnosis compared with lesions on the dorsal aspect of the foot or on the ankle (p = 0.02). The misdiagnoses included a @entity7174 (one @entity1 ), a @entity9252 (one @entity1 ), a pyogenic @entity738 (two @entity1 ), a plantar wart (three @entity1 ), a @entity4494 (one @entity1 ), a blister (two @entity1 ), and a traumatic lesion (five @entity1 ).(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX of the foot and ankle.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage-III disease', 'Cancer']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['plantar or subungual lesion']

entities_list: @entity9252 :: ('MESH:D010304', 'Disease') :: ['paronychia']

entities_list: @entity7174 :: ('MESH:D009506', 'Disease') :: ['benign nevus']

entities_list: @entity4494 :: ('MESH:D045888', 'Disease') :: ['ganglion cyst']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Malignant melanoma']


abstract: Malignant @entity788 are slow-growing @entity5 . Their relatively benign behavior makes aggressive treatment worthwhile. From January, 1987, to January, 1998, five cases of malignant @entity788 with liver @entity3 were diagnosed at the Veterans General @entity580 . Of these, three were @entity7581 and the others were vasoactive intestinal peptide ( @entity11563 , 1 case) and @entity9608 (1 case). Four @entity1 (3 with @entity7581 and 1 with @entity9608 ) had undergone cytoreductive surgery when the diagnosis of @entity3 was made. All five @entity1 underwent transcatheter arterial chemoembolization (TACE). All @entity1 had improved symptoms after cytoreductive surgery and TACE. The survival of @entity1 who underwent combined surgery and TACE was 38 and 17 months in the two @entity7581 cases, more than eight months in one @entity7581 case and more than 20 months in the @entity9608 case (these 2 @entity1 are still alive). One @entity11563 @entity1 who underwent TACE survived for 12 months. In conclusion, treatment for metastatic @entity4292 require a multidisciplinary approach. @entity3 of the @entity5 is not a contraindication for aggressive therapy. Combined cytoreductive surgery and TACE can relieve symptoms and are of benefit for @entity1 with @entity4292 with liver metastases.

title: Functional XXXX with liver @entity3 : the role of cytoreductive surgery and transcatheter arterial chemoembolization: a report of five cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic islet tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity9608 :: ('MESH:D007340', 'Disease') :: ['insulinoma']

entities_list: @entity4292 :: ('MESH:C535838', 'Disease') :: ['pancreatic islet cell tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['Hospital-Taipei']

entities_list: @entity7581 :: ('MESH:D015408', 'Disease') :: ['gastrinoma', 'gastrinomas']

answer: @entity4292 :: (MESH:C535838,Disease) :: ['pancreatic islet cell tumors']


abstract: We examined whether the cognitive dispute of @entity716 has a negative impact on the course of the therapeutic alliance. Sixty-seven @entity1 with persistent @entity716 received either cognitive behavioral therapy (CBT) or supportive therapy. Questionnaire-based alliance ratings were repeatedly obtained throughout the course of therapy. @entity1 and therapist alliance ratings were examined separately. Data analyses comprised repeated measurement analyses of variance and cluster analytic procedures. Neither @entity1 nor therapist alliance ratings showed a differential course throughout the treatments. This was despite the implementation of disputing strategies in later stages of CBT. Irrespective of the treatment condition a cluster with a positive alliance rating and a cluster with a poorer rating were found for therapist and @entity1 ratings, respectively. Baseline symptoms and insight differentiated between the types of clusters. In conclusion, CBT-specific interventions that challenge @entity716 do not necessarily negatively influence the course of the alliance.

title: Does the cognitive dispute of XXXX do harm to the therapeutic alliance?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'patient']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic symptoms']

answer: @entity716 :: (MESH:D011605,Disease) :: ['psychotic symptoms']


abstract: @entity2102 is a severe @entity532 , incalculable in its course and involving high risk for mother and fetus. Over a period of three years and eight months a total of 24 @entity1 with @entity2102 were treated at G  ttingen University Gynecological Clinic and the Gynecological Clinic of Munich Technical University. In all cases the correct diagnosis had already been made by the referring physician or by the obstetrician on admission, taking laboratory parameters into account. The chief clinical symptom was upper @entity490 , All of the @entity1 presented with @entity882 and elevated liver enzymes. The signs of @entity2142 derived from the increased @entity648 concentrations and the LDH; in 13 cases fragmentocytes were detected in the peripheral blood smear. No indications of a pronounced DIG were found. The mean time elapsed between hospitalization and delivery was six hours (0.5-40 hours); 22 @entity1 were delivered within 24 hours. Cesarean section was performed in all cases. The mean gestational age at the time of birth was 35 weeks (25-38). Three of 24 @entity1 died prepartially; with the surviving @entity1 no major problems arose in the postnatal course. In 19 cases the abdominal cesarean delivery and clinical course were without complications. Reoperation, in two cases combined with a puerperal hysterectomy, was necessary in three @entity1 , due to subfascial and intraperitoneal or retroperitoneal @entity1410 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Significance of early laboratory diagnosis for obstetrical procedures in severe gestoses and the XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP syndrome']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['complication of preeclampsia']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']

answer: @entity2102 :: (MESH:D017359,Disease) :: ['HELLP syndrome']


abstract: We have investigated the expression of @entity7131 ( @entity7131 ) and protein kinase A (PKA) during the phases of growth and differentiation of the @entity1 @entity694 Caco-2 cells. We studied whether differentiation correlated with the responsiveness to @entity268 and with an increased transport of the catalytic subunit of PKA into the nucleus. Also, we evaluated whether this phenomenon was affected by @entity7131 activity. High levels of activated @entity7131 were found in the plasma membranes of replicating cells. When the cells began to differentiate, plasma membrane-activated @entity7131 decreased, while the cytosolic fraction increased. On the contrary, PKA holoenzyme increased during differentiation, along with the transport of its catalytic subunit into the nucleus. Both types I and II kinase A holoenzymes increased during differentiation, with maximal type II activity found when cells were fully differentiated. In replicating preconfluent cells, the inhibition of @entity7131 by high dose @entity1359 or @entity5597 increased the amount of both PKA catalytic subunit in the nucleus and sucrase activity. During differentiation, @entity5987 increased PKA catalytic subunit in the nucleus and apoliprotein A1 mRNA levels. These effects were inhibited by low-dose @entity1359 , which activates @entity7131 in the plasma membranes. Our data suggest that @entity7131 is activated in proliferating Caco-2 cells. The inhibition of @entity7131 induces the transport of PKA catalytic subunit into the nucleus and the expression of the differentiation markers. Differentiated Caco-2 cells show a lower activation of @entity7131 and an increased transport of the catalytic subunit of PKA into the nucleus.(ABSTRACT TRUNCATED AT 250 WORDS)

title: The enterocyte-like differentiation of the Caco-2 tumor cell line strongly correlates with responsiveness to XXXX and activation of kinase A pathway.

entities_list: @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol 12-myristate 13-acetate']

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC']

entities_list: @entity5597 :: ('MESH:D013110', 'Chemical') :: ['sphingosine']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinoma']

answer: @entity268 :: (CHEBI:17489,Chemical) :: ['cAMP']


abstract: Endoscopic ultrasonography (EUS) is currently being used to evaluate and stage pancreaticobiliary @entity5 , and to perform aspiration for cytologic diagnosis. There are currently two different commercially available EUS systems for clinical use. One system uses a mechanical radial sector scanner oriented in a plane perpendicular to the long axis of the endoscope, and the other uses an electronic convex scanner that is oriented in the long axis of the endoscope. The vast majority of the current literature reports experience using the radial scanning device in the evaluation of @entity854 . We prospectively evaluated the linear probe as the sole instrument for EUS in 26 @entity1 with suspected @entity660 . The results of the endoscopic ultrasound examination were compared with the results of surgery or long-term clinical follow-up. The sensitivity and specificity of linear array EUS for benign @entity660 were 93.8% and 88.2%, respectively. The sensitivity and specificity for @entity5 were 80.0% and 88.9%, respectively. The linear array echoendoscope, employed as the only instrument for evaluation of the pancreas, is accurate in the evaluation of @entity660 . The addition of EUS-guided pancreatic biopsy would be anticipated to improve the sensitivity of the linear array instrument for detecting @entity5 .

title: Utility of a linear array ultrasound endoscope in the evaluation of suspected XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies and neuroendocrine tumors', 'malignant disease of the pancreas', 'malignancy']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['pancreaticobiliary abnormalities']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic disease']

answer: @entity660 :: (MESH:D010182,Disease) :: ['pancreatic disease']


abstract: BACKGROUND/AIMS: This study documents the clinical efficacy and @entity137 of @entity1205 and @entity1814 in @entity900 -pretreated relapsed or refractory esophageal @entity1544 . METHODOLOGY: From February 2002 to February 2007, 20 @entity1 with metastatic or locally recurrent or @entity66 previously treated with @entity900 -based chemotherapy or chemoradiotherapy were included. The median age was 66.0 (range 52-74) years, and 17 @entity1 had undergone a previous esophagectomy. A total of 36 cycles with @entity1205 60 mg/m2 plus @entity1814 80 mg/m2 were administered. RESULTS: The response rate was 25% including one complete response, and the rate of disease stabilization (% of complete response, partial response and stable disease) was 80%. The median progression-free survival was 14 weeks and the median overall survival was 26 weeks. Severe @entity1398 occurred in 12 @entity1 (grade 3/4 = 4/8) and 5 out of 20 @entity1 showed severe @entity1398 (grade 3/4 = 4/1), whereas no severe @entity1503 was observed. CONCLUSIONS: In conclusion, the combination chemotherapy of @entity1205 and @entity1814 did not show drastic clinical efficacy. However, it was considered to be a feasible regimen as @entity5 dormancy therapy in CDDP-pretreated @entity418 , and to have a potent possibility to become a useful second-line chemotherapy for relapsed or @entity418 . The control and prevention of severe @entity1398 and @entity1398 is also very important in use of this regimen.

title: A pilot trial of @entity1205 and @entity1814 in XXXX -pretreated relapsed or refractory esophageal @entity1544 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['non-hematological toxicity']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancer']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia', 'febrile neutropenia']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer', 'refractory esophageal cancer']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

entities_list: @entity1814 :: ('MESH:C053989', 'Chemical') :: ['nedaplatin']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: The authors describe a case of a 47-year-old male smoker with a 3-month history of @entity393 , @entity392 and @entity1296 . Physical examination revealed @entity393 . Small rounded hypodensities without mass effect were evident in a computed tomography scan of the head, confirmed by brain magnetic resonance imaging as multiple @entity5409 in both cerebral and cerebellar hemispheres, without perilesional @entity4 or @entity2287 enhancement, suggestive of @entity6583 . Extraparenchymal involvement was also noted. @entity3753 and @entity619 were started. As a chest radiograph showed a bilateral reticulonodular pattern, a bronchoscopy was performed showing normal results. However, transbronchial biopsy revealed @entity2220 . Thoracoabdominopelvic computed tomography scan showed secondary lung and @entity79 . Since @entity75 were not suggestive of @entity5 , a brain biopsy was performed confirming @entity3 . This case illustrates some peculiar imagiological features of brain metastases in @entity2 , indicating that sometimes invasive procedures are required to establish a definitive diagnosis.

title: XXXX : atypical brain metastases mimicking @entity6583 .

entities_list: @entity3753 :: ('MESH:D015766', 'Chemical') :: ['Albendazole']

entities_list: @entity6583 :: ('MESH:D020019', 'Disease') :: ['neurocysticercosis']

entities_list: @entity5409 :: ('MESH:D052177', 'Disease') :: ['cystic lesions']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['secondary tumor lesions']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone lesions']

entities_list: @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss', 'neurosensory hearing loss']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Lung cancer']


abstract: Urinary output, a key parameter guiding fluid resuscitation in burn @entity130 , is an inadequate measure of renal function. In this study, the clearance of @entity6111 (CL) was used to follow the glomerular filtration rate during the first week after burn. Nineteen adults with major burns received an intravenous bolus injection of @entity6111 every other day. Plasma concentration of @entity6111 was measured over 4h and CL was calculated by a one-compartment kinetic model. The results were compared to the CL as obtained by a two-compartment model and also to the CL measured in 10 healthy controls. The results show that CL values for burn @entity1 were high. The first day after burn, median CL was 155 mL/ @entity1009 .73 m(2) (range 46-237), which exceeded that for the controls (mean 117 mL/ @entity1009 .73 m(2); P<0.01). However, on day 7 the CL approached the expected baseline (mean 122 mL/ @entity1009 .73 m(2)). CL was 10% lower when calculated from two-compartment kinetics, and a correction factor of 0.9 was applied to all results obtained by the one-compartment calculations to give results comparable to those from the two-compartment kinetics. In conclusion, CL is increased early after burn. The mechanism is unclear but it parallels the @entity455 and increased cardiac output.

title: Glomerular filtration rate is increased in burn XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['period of vascular dysfunction']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity455 and accumulation of oxidative stress have been associated with @entity740 ( @entity740 ). Dialysis modalities, @entity298 ( @entity298 ) and haemodialysis (HD) may differentially impact on vascular function and oxidative stress. METHODS: @entity1 undergoing living donor transplantation were studied for @entity455 using pulse wave velocity measurements, and inferior epigastric arteries were harvested to examine in vitro stiffness and functional properties and evidence of oxidative stress. Forty-one @entity1 were studied representing @entity298 (n = 12), HD (n = 14) and non-dialysed recipients (n = 15). RESULTS: We demonstrated differences in stiffness from in vivo and in vitro measurements such that non-dialysis < HD < @entity298 groups. The stiffness measurements did not correlate with duration of @entity740 nor dialysis duration, but did so with @entity1391 levels (r = 0.356, P = 0.02). From the in vitro isometric force experiments, HD arteries demonstrated decreased contractility and endothelium-dependent relaxation compared with @entity298 and non-dialysis vessels. Level of oxidative stress (as indicated by the @entity7707 level) was 30% higher in HD arteries than in @entity298 arteries. Protein expression of inducible @entity842 synthase, @entity1110 subunits and @entity3624 oxidase was upregulated in HD arteries, while @entity224 dismutase was downregulated. The compromised vascular function in HD arteries was improved by pharmacological means that eliminated oxidative stress. CONCLUSIONS: We report associations between vasomotor function and oxidative stress in the vasculature of @entity1 receiving different dialysis therapies. @entity66 , which may be differentially augmented during @entity298 and HD, may play an important role in the @entity455 in dialysis populations.

title: Arterial stiffness and functional properties in XXXX @entity1 on different dialysis modalities: an exploratory study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction', 'vascular stiffness', 'Abnormalities of vascular function']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Oxidative stress']

entities_list: @entity3624 :: ('MESH:D019820', 'Chemical') :: ['xanthine']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity7707 :: ('MESH:C075750', 'Chemical') :: ['8-isoprostane']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD']

answer: @entity740 :: (MESH:D051436,Disease) :: ['chronic kidney disease']


abstract: PURPOSE: To estimate the prevalence of incidental @entity45 (IPCs) in asymptomatic @entity1 addressed to magnetic resonance cholangiopancreatography (MRCP), and to correlate it with clinical and imaging features. MATERIALS AND METHODS: Magnetic resonance cholangiopancreatography performed over 26-months on 152 @entity1 with unsuspected/unknown @entity660 were reviewed to assess IPCs' features of presentation. Multivariate analysis was performed to evaluate the correlation of IPCs with clinical information and type of pancreaticobiliary findings at MRCP. RESULTS: Prevalence of IPCs was 44.7%. Cysts sized 3-24 mm (mean, 6.08 mm), and were  <=4 in number in 83.8% of @entity1 . Based on number, dimensions and relation with the main pancreatic duct, IPCs presented with @entity4929 ( @entity4929 )-like or indeterminate patterns in 31.7% and 13.1% of @entity1 , respectively. At follow-up on 24 @entity1 , no evolution was found, except in one @entity1 with proven @entity4929 showing increase in cysts number and dimensions (evolution rate of 4.1%). Features correlating with IPCs were age >= 60 years old, and history of @entity792 , showing odds ratios of 5.95 (95% CI 2.77-12.79) and 0.13 (95% CI 0.04-0.44), respectively. CONCLUSIONS: Incidental @entity45 represent a frequent finding at MRCP, correlating positively with increasing age, and negatively with @entity792 . Cysts more frequently present with @entity4929 -like pattern.

title: Incidental XXXX on 3D turbo spin echo magnetic resonance cholangiopancreatography: prevalence and relation with clinical and imaging features.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['intraductal-papillary-mucinous neoplasm', 'IPMN']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic disease']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['pancreatic cysts']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune hepatobiliary disease', 'biliary autoimmune disease']

answer: @entity45 :: (MESH:D010181,Disease) :: ['pancreatic cysts']


abstract: AIM: The objective of this study was to evaluate the optimal dose, efficacy and safety of a novel @entity5735 ( @entity5735 ) inhibitor, @entity21778 , in Korean subjects with @entity6 treated by diet and exercise. METHODS: This study was a double-blind, randomized, multicenter and parallel-group, dose-range finding study. We enrolled 145 @entity1 (91 @entity1 and 54 @entity1 ) with a median age of 53 years and a median body mass index of 25.1 kg/m(2) . The median baseline fasting plasma @entity413 (FPG) was 8.1 mmol/l, the median HbA1c was 7.9% and the median time since the diagnosis of @entity6 was 3 years. After 2 weeks of an exercise/diet programme followed by 2 weeks of a placebo period, the subjects were randomized to one of the four following groups for a 12-week active treatment period: placebo and 50, 100 or 200 mg of @entity21778 . RESULTS: All three doses of @entity21778 significantly reduced the @entity4051 c from baseline compared to the placebo group (-0.06 vs. -0.98, -0.74 and -0.78% in the placebo and 50, 100 and 200 mg groups, respectively), without a significant difference between the doses. Subjects with a higher baseline HbA1c (>= 8.5%) had a greater reduction in HbA1c. Insulin secretory function, as assessed using homeostasis model assessment-beta cell, C-peptide and the insulinogenic index, improved significantly with @entity21778 treatment. Insulin sensitivity, as assessed using homeostasis model assessment-insulin resistance, also improved significantly after 12 weeks of treatment. The 50 and 200 mg groups had significantly reduced total @entity165 and low-density lipoprotein @entity165 levels at 12 weeks compared to the placebo group. No dosage of @entity21778 affected weight or waist circumference. The incidences of adverse events were similar in all study subjects. CONCLUSIONS: @entity21778 monotherapy (50 mg for 12 weeks) improved the HbA1c, FPG level, oral @entity413 tolerance test results, b-cell function and insulin sensitivity measures, and was well tolerated in Korean subjects with @entity164 2 @entity6 .

title: A multicenter, randomized, placebo-controlled, double-blind phase II trial evaluating the optimal dose, efficacy and safety of LC 15-0444 in XXXX with @entity164 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity5735 :: ('1803', 'Gene') :: ['dipeptidyl peptidase-4', 'DPP-IV']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'type 2 diabetes mellitus']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['patients']