abstract: UNASSIGNED: Background: Severe @entity221 with @entity882 (SFTS) is a newly emerging @entity166 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity1 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity404 +/total lymphocytes, @entity404 + @entity2902 +/ @entity404 + cells and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells was observed in @entity1 with SFTS compared with healthy controls. In contrast, the percentage of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in the @entity1 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity1 with SFTS at different stages. The results showed that the proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells in the non-severe group was prominently higher than that in @entity1 with severe SFTS. Conversely, the proportion of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity1 with SFTS. Our investigation suggested that the proportions of @entity404 +/total lymphocytes and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in XXXX with severe @entity221 with @entity882 .

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia syndrome']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Objective:To investigate the expression of gap junction protein connexin 26( @entity3492 ) in @entity157 ( @entity157 ) and its significance. Methods:The expression of @entity3492 in liver tissue was examined by immunohistochemistry staining in 159 paraffin-embeded liver sections, including 20 samples of normal liver tissue, 30 samples of chronic @entity99 , 33 samples of liver @entity82 , and 76 samples of @entity157 . Normal hepatic cell line LO2 and @entity157 cell line SMMC-7721 were used in vitro to verify the characteristics of gap junction and @entity3492 expression pattern. The expression and localization of @entity3492 were measured by Western blotting and immunofluorescence assay, respectively. The function of gap junction between adjacent cells was detected by dye transfer assay. Results:Compared to normal liver samples, the positive rate of @entity3492 was markedly decreased in @entity99 , @entity82 and @entity157 tissues(all P<0.05). The intensity of @entity3492 staining was significantly increased in @entity157 tissues compared with those in @entity409 (NCL) tissues(all P<0.05). In NCL tissues, there was a mild to moderated staining of @entity3492 which located mainly on the membranes of hepatocytes at intercellular contacts. The positive staining of @entity3492 in @entity157 tissues was observed mainly in cytoplasm. Positive @entity3492 expression was positively associated with @entity5 size(P=0.036), but not with age, gender, histologic grade, clinical stage, underlying @entity99 and cirhosis, lymph node @entity3 and @entity455 (all P>0.05). Compared with LO2 cells, an aberrant expression and distribution of @entity3492 in SMMC-7721 cells was confirmed, which may lead to a decreased function of gap junctions. CONCLUSIONS: The aberrant expression and distribution of @entity3492 protein may be associated with hepatocarcinogenesis, and the residual gap junction in @entity157 may provide a new target for treatment of @entity157 .

title: [Expression of gap junction protein connexin 26 in human XXXX and its significance].

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['intrahepatic vascular embolism']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['non-carcinomatous liver']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: Data are presented from 1,166 @entity1 with Dukes B and C @entity694 who were entered into the National Surgical Adjuvant Breast and Bowel Project (NSABP) Protocol C-01 between November 1977 and February 1983. @entity1 were randomized to one of three therapeutic categories: 1) no further treatment following curative resection (394 @entity1 ); 2) postoperative chemotherapy consisting of @entity1487 , @entity16418 , and @entity1891 (379 @entity1 ); or 3) postoperative BCG (393 @entity1 ). The average time on study was 77.3 months. A comparison between @entity1 receiving postoperative adjuvant chemotherapy and those treated with surgery alone indicated that there was an overall improvement in disease-free survival (P = .02) and survival (P = .05) in favor of the chemotherapy-treated group. At 5 years of follow-up, @entity1 treated with surgery alone were at 1.29 times the risk of developing a treatment failure and at 1.31 times the likelihood of dying as were similar @entity1 treated with combination adjuvant chemotherapy. Comparison of the BCG-treated group with the group treated with surgery alone indicated that there was no statistically significant difference in disease-free survival (P = .09). There was, however, a survival advantage in favor of the BCG-treated group (P = .03). At 5 years of follow-up, @entity1 randomized to the surgery-alone arm were at 1.28 times the risk of dying as were similar @entity1 treated with BCG. Further investigation disclosed that this survival advantage in favor of BCG was a result of a diminution in deaths that were @entity5 related. When analyses were conducted on which events not related to @entity5 recurrence were eliminated, the survival difference between the BCG and control groups became nonsignificant (P = .40); the cumulative odds at 5 years decreased from 1.28 to 1.10. The findings from this study are the first from a randomized prospective clinical trial to demonstrate that a significant disease-free survival and survival benefit can be achieved with postoperative adjuvant chemotherapy in @entity1 with Dukes B and C @entity694 who have undergone curative resection.

title: Postoperative adjuvant chemotherapy or BCG for XXXX : results from NSABP protocol C-01.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'non-cancer']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity16418 :: ('MESH:D012673', 'Chemical') :: ['semustine']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['carcinoma of the colon']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: BACKGROUND: Cigarette smoking is associated with a more severe @entity30 ( @entity30 ) course. However, the effect of light consumption is not known. Our aim was to characterize the effect of a light @entity286 consumption on the course of @entity30 . METHODS: We analyzed the course of @entity30 during the period 1995-2007 from data collected in 2795 consecutive @entity1 in whom smoking habits were recorded. @entity1 were classified as nonsmokers (n = 1420), light smokers (1-10 cigarettes/day; n = 385), heavy smokers (>10 cigarettes/day; n = 638), and intermittent smokers (change in smoking habits; n = 352). @entity1 -years while smoking were compared to @entity1 -years without smoking. The analyses considered @entity1 -years regarding annual disease activity and therapeutic requirements. RESULTS: The percentage of years with active disease was 37% in nonsmokers versus 46% in light smokers (P < 0.001; adjusted hazard ratio 1.30 [1.19-1.43]) and 48% in heavy smokers (P < 0.001; adjusted hazard ratio 1.68 [1.57-1.81]), despite an increased use of immunosuppressants in smokers. Hospitalization rates were also increased in both groups of smokers, with 12% in nonsmokers versus 15% in both groups of smokers (P < 0.001 for both comparisons). The annual rate of intestinal resection was 4.5% in nonsmokers, 5.1% in light smokers, and 5.5% in heavy smokers, with a significant difference observed between nonsmokers and heavy smokers only (P < 0.01). CONCLUSIONS: Light smokers are doing worse than nonsmokers regarding disease activity and the need for immunosuppressants. Complete smoking cessation should be advised in all smokers with @entity30 .

title: Effects of light smoking consumption on the clinical course of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]

answer: @entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']


abstract: Bed quilts filled with silk waste were found to cause nightly attacks of @entity565 . The first symptoms appeared on an average after 7 mo of exposure at a mean @entity1 age of 30 yr. About 50% of the @entity1 could be classified as atopic. Extract of the filling material revealed positive scratch and RAST tests in most @entity1 . The bed quilts were advertised as being filled with pure wild silk (from @entity12638 of the genus Antheraea feeding on oak leaves), but it was found that in most cases the filling also included waste of cultivated silk ( @entity12638 ). The origin of the allergen was sought. Since textile products of silk are considered to be practically nonallergenic, some type of contaminant appeared the most likely candidate. No allergen was found in cocoons, chrysalis (pupa), or moths of Antheraea. However, some cocoons of @entity12638 , usually in small amounts, and excretions of the @entity12638 did contain allergen. High concentrations of allergen were found in an extract of living insects of the genus Anthrenus that was present in one batch of @entity12638 cocoons. Thus, the silk waste appeared to be contaminated with material from the @entity12638 and also with infesting insects, which together create a very potent allergen repertoire that after a short incubation time, in a considerable frequency, elicits a rise in asthmatic symptoms and high serum IgE antibody levels.

title: Nightly XXXX caused by allergens in silk-filled bed quilts: clinical and immunologic studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity12638 :: ('7091', 'Species') :: ['silkworms', 'Bombyx mori', 'silkworm', 'silk moths']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: Traditionally, the calyx of Held synapse is viewed as a highly reliable relay in the sound localization circuit of the auditory brainstem, with every presynaptic action potential triggering a postsynaptic action potential in vivo. However, this view is at odds with slice recordings that report large @entity308 ( @entity308 ). To investigate the reliability and precision of this synapse, we compared slice and in vivo recordings from medial nucleus of the trapezoid body neurons of young adult @entity19 . We show that the extracellularly recorded complex waveform can be used to estimate both presynaptic release and postsynaptic excitability. Whereas under standard slice conditions the synapse underwent large @entity308 , both extracellular and whole-cell recordings indicated that in vivo the size of the EPSPs was independent of recent history. The estimated quantal content was typically <20 in vivo, much lower than in the resting synapse under standard slice conditions. However, due to the large quantal size and summation of EPSPs, the safety factor of this synapse was generally still sufficiently large and postsynaptic failures were observed only infrequently in vivo. When present, failures were typically due to stochastic fluctuations in EPSP size or postsynaptic spike @entity308 . In vivo, the calyx of Held synapse thus functions as a tonic synapse. The price it pays for its low release probability is an increase in jitter and synaptic latency and occasional postsynaptic failures.

title: Reliability and precision of the XXXX calyx of Held synapse.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['short-term depression', 'depression', 'STD']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: PURPOSE: Genital @entity7492 are @entity455 that often require complex management and interdisciplinary care. @entity1169 was first used to treat @entity1 with @entity7492 in 2008 and has since gained acceptance as first-line therapy. MATERIALS AND METHODS: We review the presentation, course, management and outcomes of all cases of genital @entity7492 managed by @entity1169 administration at a single institution from April 2010 to July 2014. RESULTS: During the study period 9 @entity1 with genital @entity7492 were referred to our @entity2695 treatment clinic. @entity1169 was initially administered under careful outpatient monitoring at a dose of 1 mg/kg daily in  8  @entity1 . One @entity1 , a 700 gm premature @entity1 , was started on therapy in  the inpatient setting at 0.5 mg/kg daily, given the history of prematurity. All @entity1 underwent successful increase of dose to at least 2 mg/kg for the observation phase after tolerating the starting doses. One @entity1 discontinued @entity1169 prematurely per parental request due to concern regarding peripheral vasoconstriction. Otherwise, no @entity1 demonstrated significant @entity551 , symptomatic @entity1168 , @entity4053 or other major side effect requiring treatment discontinuation. All @entity1 who continued the treatment protocol had excellent response to therapy. CONCLUSIONS: @entity1169 therapy for genital @entity7492 was successfully initiated and the dosage increased in 9 young @entity1 without significant side effects and with marked improvement in all @entity1 who continued on  treatment. @entity1169 is the only Food and Drug Administration approved therapy for treatment of @entity1 with this @entity455 and should be considered first-line therapy for genital @entity7492 .

title: XXXX for Treatment of Genital Infantile Hemangioma.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'infant']

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol', 'Propranolol']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular anomaly', 'vascular anomalies']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma']

entities_list: @entity7492 :: ('MESH:C535860', 'Disease') :: ['infantile hemangiomas']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

answer: @entity1169 :: (MESH:D011433,Chemical) :: ['Propranolol']


abstract: The aim of this study was to assess whether @entity876 codon 72 polymorphism is associated with an increased risk of @entity2 ( @entity2 ) in a South Korean population. We conducted a population-based, large-scale, case-control study including 3939 @entity1 with @entity2 and 1700 controls. @entity876 codon 72 polymorphism was determined by real-time polymerase chain reaction (PCR). The frequencies of @entity876 codon 72 polymorphisms ( @entity534 / @entity534 , @entity534 /Pro, and Pro/Pro) in @entity2 were 37.0%, 46.2%, and 16.7%, respectively; frequencies in the controls were 43.2%, 45.6%, and 11.2%, respectively (p<0.01). The @entity534 /Pro and Pro/Pro genotype were significantly associated with increased risk of @entity2 (odds ratio (OR)=1.22, 95% confidence interval (CI)=1.06-1.14 and OR=1.83, 95% CI=1.48-2.26, respectively) compared with the @entity534 / @entity534 genotype. Risk was compared in different subgroups. The OR of Pro/Pro genotype was significantly higher in @entity151 ( @entity151 ) and @entity957 ( @entity957 ) than in @entity420 ( @entity420 ). Higher OR of Pro/Pro genotype was also seen among males. However, relationships between gender, age, smoking, and genotypes were not found. @entity876 codon 72 polymorphism was associated with an increased risk of @entity2 in this Korean population; the association was especially noteworthy in @entity957 , @entity151 , and males.

title: @entity876 codon 72 polymorphism and the risk of XXXX in a Korean population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SQC']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'LC']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['SCC', 'small cell lung cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['ADC', 'adenocarcinoma']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: PURPOSE: To compare the @entity137 , gelatinolytic activity, and protein levels ( @entity1476 and @entity1495 ) produced by 3T3 fibroblasts cells after stimulation with GuttaFlow 2 and AH Plus. METHODS: 3T3 fibroblasts were incubated with elutes of GuttaFlow 2 and AH Plus for 24 h. The @entity137 of tested materials was determined using the @entity98 and the LDH assay. Supernatants of cell cultures incubated with sealers were collected to determine the levels of @entity1476 and @entity1495 gelatinolytic activity by gelatin zymography. Cell lysates were used to determine @entity1476 and @entity1495 protein levels by Western Blot. Data were analyzed using ANOVA and Tukey test (P<0.05). RESULTS: AH Plus showed significantly less cell viability (mitochondrial activity of cells) than GuttaFlow 2 (P<0.01). Moreover, GuttaFlow 2 was noncytotoxic, showing no statistically significant difference in LDH leakage levels compared to the control group (P>0.05). Specific characterization of MMPs demonstrated that GuttaFlow 2 seemed not to affect @entity1476 levels compared with the control group, while AH Plus had elevated gelatinolytic activity and protein levels of @entity1476 as confirmed by quantitative measurements. No detectable gelatinolytic activity or protein levels of @entity1495 (92 kDa) was observed in any tested group. CONCLUSIONS: GuttaFlow 2 did not showed cytotoxic effects and did not induce @entity1476 or @entity1495 expression.

title: XXXX and gelatinolytic activity of a new silicon-based endodontic sealer.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

answer: @entity137 :: (MESH:D064420,Disease) :: ['Cytotoxicity']


abstract: BACKGROUND: Despite broad clinical use of the American Association of the Surgery of @entity130 (AAST) injury scale for kidney, it has only been found to predict the need for renal surgery in single institution series. We sought to validate this scheme for morbidity and mortality in a national cohort of @entity1 with @entity8 . METHODS: A retrospective cohort design was used to determine the association between increasing AAST scores and nephrectomy, dialysis, and mortality. The cohort included all @entity1 with a @entity8 in the National @entity130 Data Bank (NTDB) from 1994 and 2003. Univariate and multivariate prediction models were used for analysis of data. RESULTS: At the time of review, a total of 742,774 @entity1 records were registered in the NTDB. @entity8 occurred in 8465 @entity1 (1.2%). Increasing injury grade was associated with a greater nephrectomy (RR 12-127), dialysis (RR 1.3-4.7), and mortality (RR 1.3-1.9) rate for blunt @entity8 . For penetrating injury, nephrectomy was the only outcome that was associated with higher grades of @entity8 with a RR of 7.7 to 31 for grades III to V @entity130 . CONCLUSION: The AAST injury scale for kidney predicts for morbidity in blunt and penetrating @entity8 and for mortality in @entity1913 . Thus, we continue to support its use as a clinical and research tool.

title: American Association for the Surgery of @entity130 Scale for kidney @entity130 predicts nephrectomy, dialysis, and death in XXXX with @entity1913 and nephrectomy for penetrating @entity130 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1913 :: ('MESH:D014949', 'Disease') :: ['blunt injury']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney injury', 'Renal injury', 'renal injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'Trauma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: We examined the effects of @entity38001 in @entity35 subjected to @entity8638 ( @entity8638 ). @entity38001 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8638 . Oxidative stress markers were assessed on days 7 and 14. @entity8638 @entity35 exhibited a marked mechanical @entity1931 , @entity1931 , and thermal @entity1931 on days 3, 5, 7, 10, and 14 post- @entity8638 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity2310 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8638 animals. @entity1234 increased and reduced @entity2041 decreased on day 14. @entity38001 significantly attenuated behavioral changes associated with @entity16 . @entity2310 decreased, while @entity1976 was increased by @entity38001 on day 3. @entity38001 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity9 pathogenesis. It is suggested that antinociceptive effects elicited by @entity38001 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of @entity38001 in @entity9 Induced by Chronic Constriction Injury in XXXX .

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia', 'cold allodynia', 'hyperalgesia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity38001 :: ('MESH:C058956', 'Chemical') :: ['Verbascoside', 'verbascoside']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde']

entities_list: @entity8638 :: ('MESH:D020208', 'Disease') :: ['chronic constriction injury', 'CCI']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: BACKGROUND: In the USA, ethnic disparities in @entity731 persist after accounting for known risk factors. Ambient air pollution is associated with increased levels of @entity731 and differs in the USA by race/ethnicity. We estimated the influence of ambient air pollution exposure to ethnic differences in common carotid @entity121 ( @entity121 ). METHODS: We cross-sectionally studied 6347 Caucasian-American, African-American, Hispanic and Chinese adults across 6 US cities in 2000-2002. Annual ambient air pollution concentrations (fine particulate matter [PM2.5] and @entity28600 of @entity1568 [NOX]) were estimated at each @entity1 's residence. @entity121 was assessed by ultrasound. RESULTS: The mean @entity121 was 19.4 and 37.6    m smaller for Hispanic @entity1 and @entity1 , 53.6 and 7.1    m smaller for Chinese @entity1 and @entity1 , and 23.4 and 38.7    m higher for African-American @entity1 and @entity1 compared with Caucasian-American @entity1 and @entity1 . After adjustment for PM2.5, the differences in @entity121 remained similar for Hispanic and African-American @entity1 but was even more negative for Chinese @entity1 (mean @entity121 difference of -58.4    m for @entity1 and -15.7    m for @entity1 ) compared with Caucasian-American @entity1 . The @entity121 difference in Chinese @entity1 compared with Caucasian-American @entity1 related to their higher PM2.5 exposures was 4.8    m (95% CI 0.2 to 10.8) for @entity1 and 8.6    m (95% CI 3.4 to 15.3) for @entity1 . NOX was not related to ethnic differences in @entity121 . CONCLUSIONS: The smaller carotid @entity121 levels in Chinese @entity1 were even smaller after accounting for higher PM2.5 concentrations in Chinese @entity1 compared with Caucasian-American @entity1 . Air pollution was not related to @entity121 differences in African-American and Hispanic @entity1 compared with Caucasian-American @entity1 .

title: Ambient air pollution and racial/ethnic differences in carotid XXXX in the Multi-Ethnic Study of @entity731 (MESA).

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'participant', 'men']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

answer: @entity121 :: (MESH:D009135,Disease) :: ['intima-media thickness']


abstract: Compared to in vivo development, in vitro culture of @entity1 embryos results in @entity851 . To study the potential of reversibility of @entity851 we investigated ultrastructurally day 3 @entity95 embryos after 1 day in vitro, and cultured embryos that were transferred after culture into recipient @entity95 for 1 day. Morphology was compared with ultrastructure of noncultured controls. The noncultured embryos were compacted morulae; the characteristic ultrastructure is described in detail. After 1 day in culture, morulae had developed into early blastocysts. However, unlike the results in vivo, expansion of the blastocysts did not occur and some of the cultured embryos developed trophoblast herniations. In all cultured embryos morphological signs of @entity528 were seen with swollen mitochondria, with a dense, granular appearance of the cytoplasm, and with an increase in number of lysosomes. Transfer of cultured blastocysts into uteri of day 3 pseudopregnant recipients resulted in ultrastructurally intact and expanded blastocysts. Transfer into uteri of day 4 pseudopregnant recipients and into uteri of nonpregnant recipients, however, did not yield reversibility of the unphysiological features suffered during the previous time in culture. Although blastocysts were well expanded, distinct signs of @entity130 were present, proceeding from loss of complete blastomeres to structural changes such as large lamellar structures, dilation of smooth endoplasmic reticulum and Golgi complexes, and clumping of mitochondria. We conclude that @entity851 during in vitro culture is accompanied by distinct morphological changes. As soon as 24 hr after transfer, these changes can be reversed. This compensation, however, is achieved only if embryos are transferred into recipients that are adapted to the embryo's developmental stage, which is not identical to the embryo's chronological age. Our findings demonstrate that the period of 24 hr of in vitro development matches only a few hours of in vivo development.

title: Development of preimplantation XXXX embryos after in-vitro culture and embryo transfer: an electron microscopic study.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['developmental retardation', 'growth retardation']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['degeneration']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injury to the blastomeres']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: Extracellular @entity855 is known to mediate fast, excitatory neurotransmission through activation of ionotropic P2X receptors. In this study, the localization of the P2X(2) receptor (P2X(2)R) subunit was studied in @entity35 retina by using immunofluorescence immunohistochemistry and preembedding immunoelectron microscopy. The P2X(2)R was observed in large ganglion cells as well as in a subset of amacrine cells. Double labeling revealed that 96% of all P2X(2)R-immunoreactive amacrine cells showed @entity1246 ( @entity1246 ) immunoreactivity. Subsets of P2X(2)R-immunoreactive amacrine cells expressed @entity842 synthase and substance P; however, no colocalization was observed with @entity1877 acetyltransferase, vasoactive intestinal peptide, or @entity669 hydroxylase. Nearest-neighbor analysis confirmed that P2X(2)Rs were expressed by a heterogeneous population of amacrine cells. The synaptic connectivity of P2X(2)R amacrine cells was also investigated. It was interesting that P2X(2)R-immunoreactive amacrine cell dendrites stratified in the sublaminae of the inner plexiform layer occupied by cone, but not rod bipolar cell axon terminals. Immunoelectron microscopy revealed that P2X(2)-immunoreactive amacrine cell processes were associated with cone bipolar cell axon terminals as well as other conventional synapses in the inner plexiform layer. Taken together, these data provide further evidence for the involvement of extracellular @entity855 in neuronal signaling in the retina, particularly within cone pathways.

title: P2X2 receptors on ganglion and amacrine cells in cone pathways of the XXXX retina.

entities_list: @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: To identify the presence of orexin receptor 1 (OXR1) in @entity28 @entity35 pancreas and clarify its effect and mechanism on body weight and metabolic index in @entity28 @entity35 . METHODS: The @entity28 @entity35 model was established a high-fat diet. And the serum levels of @entity413 , @entity412 and insulin were measured by Mini-Blood @entity413 meter, biochemical enzymatic method and chemiluminescent immunoassay. The pancreatic expression of @entity24210 protein was identified by immunohistochemistry. After an intracerebroventricular infusion of orexin receptor 1 antisense oligodeoxynucleotide ( @entity24210 -PS-ODNs), the effect on @entity24210 protein was detected in @entity35 pancreatic tissue with @entity28 . RESULTS: After feeding for 8 weeks, high-fat diet @entity35 appear @entity28 body weight, serum @entity413 , insulin, @entity412 and @entity165 of high-diet @entity35 were higher than those in the control group (P < 0.05). The expression of @entity24210 protein was located in the cytoplasm of pancreas Islet b-cells. The expression of @entity24210 protein in @entity28 @entity35 pancreas decreased around 16% versus the normal group (P < 0.05). After the @entity28 @entity35 were treated by @entity24210 -PS-ODNs for 72 hours, the expression of @entity24210 protein in pancreas declined from 82    6 to 65    4, reduced about 21% compare with control group (P < 0.01). CONCLUSION: The expression of @entity24210 protein is found in pancreas Islet b-cells. Hypothalamic orexin system can intervene the expression of @entity24210 protein in @entity35 pancreatic tissue with @entity28 . And it may participate in the occurrence of @entity28 and the metabolic regulation of serum @entity413 and insulin.

title: [Expression of orexin receptor 1 in XXXX pancreatic tissue with @entity28 ].

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['alimentary obesity', 'obese', 'obesity']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: Tissue Doppler imaging (TDI) is a noninvasive echocardiographic method for the diagnosis of @entity67 in @entity1 with varying degrees of @entity472 ( @entity472 ). Little is known however, on the utility of TDI in the serial assessment of @entity854 in @entity472 . OBJECTIVE: The aim of the current proposal was to examine whether treatment with @entity8671 was successful in improving @entity854 in @entity1 enrolled in the Aortic Stenosis Progression Observation Measuring Effects of @entity8671 (ASTRONOMER) study. METHODS: Conventional Doppler indices including peak early (E) and late (A) transmitral velocities, and E/A ratio were measured from spectral Doppler. Tissue Doppler measurements including early (E') and late (A') velocities of the lateral annulus were determined, and E/E' was calculated. RESULTS: The study population included 168 @entity1 (56    13 years), whose @entity472 severity was categorized based on peak velocity at baseline (Group I: 2.5-3.0 m/s; Group II: 3.1-3.5 m/s; Group III: 3.6-4.0 m/s). Baseline and follow-up hemodynamics, LV dimensions and diastolic functional parameters were evaluated in all three groups. There was increased @entity67 from baseline to follow-up in each of the placebo and @entity8671 groups. In @entity1 with increasing severity of @entity472 in Groups I and II, the lateral E' was lower and the E/E' (as an estimate of increased left ventricular end-diastolic pressure) was higher at baseline (p < 0.05). However, treatment with @entity8671 did not affect the progression of @entity67 from baseline to 3.5 year follow-up between @entity1 in any of the three predefined groups. CONCLUSION: In @entity1 with mild to moderate asymptomatic @entity472 , @entity8671 did not attenuate the progression of @entity67 .

title: Evaluating the effectiveness of XXXX in preventing the progression of @entity67 in @entity472 : A substudy of the @entity472 progression observation measuring effects of @entity8671 (ASTRONOMER) study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin', 'Rosuvastatin']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['AS', 'aortic stenosis']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['diastolic abnormalities']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']

answer: @entity8671 :: (MESH:C422923,Chemical) :: ['rosuvastatin']


abstract: @entity409 (UELS) is a rare @entity5 that typically occurs in @entity1 . The association of UELS with @entity5 other than @entity409 is exceedingly rare. The aim of the study was to report 3 cases of UELS, 2 of them being interesting because of their association with another @entity5 , vaginal @entity2875 in a teenage @entity1 and @entity981 in a middle-aged @entity1 . Besides, one of our cases of UELS, in a 58-year-old @entity1 , is an extremely rare presentation of such a @entity5 in a middle-aged adult. The @entity1 's clinical features, therapy, and pathologic results were reviewed; immunohistochemical analysis and, in 2 cases, electron microscopy were performed. In this study, all 3 @entity1 were females aged 13, 13, and 58 years. Histopathologic evaluation of resected @entity96 confirmed the diagnosis of UELS in all of them. In 2 of the cases, metachronous occurrence of UELS with vaginal @entity2875 in a teenage @entity1 and @entity981 in a middle-aged @entity1 is described. Careful clinical analysis, histologic studies, and immunohistochemistry are mandatory to distinguish UELS from other @entity99 with similar or overlapping features and to exclude the possibility of other @entity5 that may be considered in the differential diagnosis. The association of UELS with another @entity5 is exceedingly rare.

title: XXXX : synchronous and metachronous occurrence with @entity5 other than @entity409 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girl', 'woman', 'patients', 'patient']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['B-acute lymphoblastic leukemia']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'neoplasm']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Undifferentiated (embryonal) liver sarcoma', 'mesenchymal liver hamartoma']

entities_list: @entity2875 :: ('MESH:D018233', 'Disease') :: ['embryonal rhabdomyosarcoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic malignancies']

answer: @entity409 :: (MESH:D008107,Disease) :: ['Undifferentiated (embryonal) liver sarcoma']


abstract: UNASSIGNED: Horticulture makes intensive use of soil and extensive use of @entity691 (PE) sheeting and pesticides, producing an environment where the dynamics between soil and plastics can affect pesticide fate. We have determined that the presence of plastic residues in the horticultural soil of small production units equals 10% of the soil area, being meso and macro-sections the predominant fragment sizes. All soil samples were taken from different plots located in Cuartel V, Moreno district, in the suburbs of Buenos Aires city, Argentina. Laboratory experiments were conducted to see the relations among pesticide, soil and PE film. Endosulfan recovery from LDPE films (25 m and 100 m) was studied, observing evidence that indicated migration to the inside of the plastic matrix. To further analyze the dynamics of pesticide migration to soil and atmosphere, experiments using @entity10687 , @entity22429 and @entity14459 were performed in soil-plastic-atmosphere microenvironments, showing that up to 24h significant amounts of pesticides moved away from the PE film. To determine whether PE residues could act as potential pesticide collector in soil, column elution experiments were done using @entity10687 , @entity22429 and @entity14459 . Results showed an important pesticide accumulation in the mulch film (584 g-2284 g pesticide/g plastic) compared to soil (13 g-32 g pesticide/g soil). Finally, chemical and photochemical degradation of @entity316 adsorbed in PE film was studied, finding a protective effect on hydrolysis but no protective effect on photodegradation. We believe that a deeper understanding of the dynamics among soil, plastic and pesticides in horticultural productive systems may contribute to alert for the implications of PE use for plastic sheeting.

title: XXXX film incorporation into the horticultural soil of small periurban production units in Argentina.

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['polyethylene']

entities_list: @entity22429 :: ('MESH:C035988', 'Chemical') :: ['procymidone']

entities_list: @entity14459 :: ('MESH:D014274', 'Chemical') :: ['trifluralin']

entities_list: @entity316 :: ('MESH:C017180', 'Chemical') :: ['deltamethrin']

entities_list: @entity10687 :: ('MESH:D004390', 'Chemical') :: ['chlorpyrifos']

answer: @entity691 :: (MESH:D020959,Chemical) :: ['Polyethylene']


abstract: @entity9317 produced by @entity461 occurred in 4.5% of the @entity1 hospitalized in our service. Often was associated with duodenal or gastric peptic ulcer, @entity357 and with some other @entity4801 ; particularly with ambiasis. Forty four @entity1 were studied in whom the only cause to demonstrate or explain their symptomatology was the presence of @entity461 in the duodenum. The complaints disappeared after the administration of specific treatment. The clinical manifestations remained an atypic @entity1066 without defined rhythm or periodicity; however, @entity338 are frequently present. The physical exploration does not help to the diagnosis. Gastric acidity is normal. X-ray studies demonstrate irregular mucosa of the stomach and duodenum and some spastic waves. Duodenoscopy allows to watch inflammatory changes of the duodenal mucosa and rules out peptic ulcer. The diagnosis is confirmed by the demonstration of the parasite, present in the fluid aspirated from the duodenum during the endoscopy.

title: [ @entity9317 caused by XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer syndrome']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['hiatus hernia']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['heartburn and regurgitation']

entities_list: @entity461 :: ('5741', 'Species') :: ['Giardia lamblia']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic diseases']

entities_list: @entity9317 :: ('MESH:D004382', 'Disease') :: ['Duodenitis']

answer: @entity461 :: (5741,Species) :: ['Giardia lamblia']


abstract: @entity1 apical @entity1372 -dependent @entity6741 transporter ( @entity21514 ) is a potential prodrug target under study. Development of prodrugs that target @entity21514 may yield compounds with low solubility and/or susceptibility to hydrolysis. A transport uptake method is needed that increases compound solubility and avoids @entity6674 for cell lysis during postexperimental cell sample preparation. The overall goal was to develop an assay method to screen for @entity21514 uptake of novel compounds. The first objective was to determine the maximum cosolvent concentrations that are compatible with an @entity21514 active transport assay. The second objective was to develop a @entity6674 -free cell lysis method to process cell samples from these uptake studies. The following cosolvents were studied: @entity9105 ( @entity9106 ), @entity6442 ( @entity9104 ), @entity3733 ( @entity3733 ), @entity1068 , @entity1042 , @entity968 , @entity2771 , and @entity6246 . Initial studies included @entity7362 flux studies across @entity21514 -Madin-Darby @entity235 kidney monolayers using up to 10% cosolvent, as well as @entity137 studies. The effect of selected cosolvent concentrations on the @entity21514 Michaelis-Menten kinetic parameters was evaluated. Additionally, two @entity1626 -based cell lysis methods that do not use @entity6674 were evaluated in terms of percent sample recovery and @entity21514 kinetic parameters. Results showed that the maximum permissible cosolvent concentrations for @entity21514 uptake studies, without compromising assay results or causing @entity137 , are 1% @entity9106 , 1% @entity9104 , 2.5% @entity3733 , 2.5% @entity1042 , and 2.5% @entity1068 . Additionally, both @entity6674 -free, @entity1626 -based cell lysis methods provided similar recovery and @entity21514 results, compared to @entity6674 method. Hence, an assay method was developed to screen for active transport, allowing for cosolvents that can solubilize compounds and avoid @entity6674 sample treatment, which can otherwise degrade compound.

title: Method to screen substrates of apical XXXX -dependent @entity6741 transporter.

entities_list: @entity7362 :: ('MESH:D013656', 'Chemical') :: ['taurocholate']

entities_list: @entity2771 :: ('MESH:D019946', 'Chemical') :: ['propylene glycol']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile']

entities_list: @entity9105 :: ('MESH:C013959', 'Chemical') :: ['dimethylacetamide']

entities_list: @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethylsulfoxide', 'DMSO']

entities_list: @entity6442 :: ('MESH:D004126', 'Chemical') :: ['dimethylformamide']

entities_list: @entity6741 :: ('CHEBI:3098', 'Chemical') :: ['bile acid']

entities_list: @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol-400']

answer: @entity1372 :: (MESH:D012964,Chemical) :: ['sodium']


abstract: OBJECTIVE: To investigate the clinical feature of the chronic @entity1781 without @entity1952 . METHODS: Retrospective cases series study. The clinical data of 25 @entity1 (37 eyes) with chronic @entity1781 without @entity1952 , treated in Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, from October, 2005 to March, 2014, were collected. Those @entity1 had been showing visual symptoms for 6 months or longer, but missed diagnosed or misdiagnosed as other @entity2194 due to their normal or slightly changed fundi. The collected data including visual acuities, visual fields, neuroimaging and/or pathologic diagnosis were analyzed. RESULTS: Among the 25 @entity1 , there were 5 males and 20 females, and their ages range from 9 to 74 years [average (47.5    13.4) years]. All @entity1 suffered progressive @entity2194 , without @entity2358 . Except one @entity1 had a @entity10 , other @entity1 did not show systemic symptoms. The corrected visual acuities were between HM to 1.0, and their appearances of optic discs and colors of fundi were normal. After neuroimaging and/or pathological examination, it was proven that 14 @entity1 suffered @entity1653 , 5 @entity1 with hypophysoma, 3 @entity1 with @entity1781 in orbital apex, 1 @entity1 with @entity2477 , 1 @entity1 with @entity1462 in orbital apex and 1 @entity1 with @entity5150 . Among the 19 @entity1 whose suffered occupied lesions of saddle area, 14 @entity1 underwent visual field examinations, and only 4 @entity1 showed classic @entity227 caused by optic chiasmal lesions. CONCLUSION: Occult progressive @entity227 was the most important clinical feature of the disease.

title: [Clinical feature of chronic @entity1781 without XXXX .]

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['impaired vision in single eye or both eyes', 'eye diseases']

entities_list: @entity1952 :: ('MESH:D009896', 'Disease') :: ['optic atrophy']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual field defects']

entities_list: @entity2358 :: ('MESH:D020820', 'Disease') :: ['exophthalmos or abnormal eye movements']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['tuberculum sellae meningiomas']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic nerve sheath meningioma', 'compressive optic neuropathy']

entities_list: @entity5150 :: ('MESH:D020339', 'Disease') :: ['optic nerve glioma']

entities_list: @entity2477 :: ('MESH:D006392', 'Disease') :: ['cavernous hemangioma']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1462 :: ('MESH:D054079', 'Disease') :: ['vascular malformation']

answer: @entity1952 :: (MESH:D009896,Disease) :: ['optic atrophy']


abstract: BACKGROUND: The activity of lysosomal enzymes is increased in body fluids during @entity32 , in which cellular malfunction and cellular death occurs. Because chemotherapy also causes cell malfunction and death, for identifying a neurologic effect, we studied the activity of beta-glucuronidase in the cerebrospinal fluid (CSF) of leukemic @entity1 during treatment. PROCEDURE: The beta-glucuronidase activity in CSF was determined in 13 @entity1 with B-precursor @entity981 ( @entity981 ) treated with the medium risk arm of @entity981 (BFM) 95 protocol. Plasma @entity1499 ( @entity1500 ) levels were determined at 24 and 48 hr after the infusion of high-dose (5 g/m(2)/24 hr) @entity1500 (MCA phase). RESULTS: The mean (SD) beta-glucuronidase activity prior to the onset of chemotherapy was 19.9 (5.6) nmoles/ @entity11108 /ml/hr. No significant changes in activity were noted during the phases of the protocol except of the MCA3. The activity was 24.4 (6.8) on MCA2, 28.4 (9.3) on MCA3, and 24.1 (9.5) on MCA4. The beta-glucuronidase activity was positively correlated with the plasma @entity1500 levels at both 24 hr (r = 0.483, P = 0.006) and 48 hr (r = 0.676, P < 0.0001). No progressive changes were noted during the different phases of the protocol. The greatest beta-glucuronidase activity was measured in two @entity1 with @entity2359 . CONCLUSIONS: The beta-glucuronidase activity is increased in the CSF of leukemic @entity1 receiving high-dose @entity1500 and particularly in @entity2359 . It is positively correlated with plasma @entity1500 levels. No cumulative effect of the chemotherapy was observed. The increased beta-glucuronidase activity is most likely due to enzyme leakage through the cell membranes caused mainly by a toxic effect of @entity1500 on the cells of the central nervous system (CNS).

title: Correlation of cerebrospinal fluid beta-glucuronidase activity with plasma XXXX concentrations in leukemic @entity1 receiving high-dose @entity1499 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL Berlin-Frankfurt-Munster', 'ALL', 'acute lymphoblastic leukemia']

entities_list: @entity11108 :: ('MESH:C489431', 'Chemical') :: ['4-methylumbelliferone']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: BACKGROUND/AIMS: @entity3885 is the most common cause of @entity3181 in Orientals. Recently, percutaneous @entity661 (PTBA) has been successfully applied as a treatment of @entity3885 . We evaluated etiologies and clinical manifestations in our cases and the usefulness of PTBA. METHODS: Twelve cases of @entity3181 were analyzed. RESULTS: 50.3 years was the average age of the cases (ranging from 37 to 67 years). Major symptoms or signs were superficial collateral vessels on the chest or the abdomen in 6 cases, @entity843 in 3, @entity490 in 4, @entity382 in 4, @entity381 in 3, melena or hematemesis in 2, and leg @entity4 in 2. Upper @entity344 showed esophageal varices in 6 cases and two of these 6 cases had @entity2312 . Of 8 cases with @entity1575 , 4 were classified as @entity1 -Pugh class A and 4 as B. Four @entity1 with @entity82 had concurrent @entity157 including 1 @entity1 who was HBs Ag positive. Etiologies were @entity3885 in 11 cases and @entity7131 in 1 case. The main site of obstruction was IVC in 8 and hepatic vein in 4. PTBA was successfully performed in 8 cases of @entity3885 . During the mean follow-up period of 27.6 months (12-40 months), there were no reobstructions except in 2 cases. CONCLUSIONS: The most common cause of @entity3181 in our cases was @entity3885 of IVC. Percutaneous @entity661 is a very useful treatment method.

title: [The usefullness of percutaneous @entity661 in the management of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients', 'patient']

entities_list: @entity382 :: ('MESH:D006529', 'Disease') :: ['hepatomegaly']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['membranous obstruction', 'Membranous obstruction']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal endoscopy']

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein C deficiency']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['transluminal balloon angioplasty']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity3181 :: ('MESH:D006502', 'Disease') :: ['Budd-Chiari syndrome']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity2312 :: ('MESH:D004932', 'Disease') :: ['gastric varices']

answer: @entity3181 :: (MESH:D006502,Disease) :: ['budd-Chiari syndrome']


abstract: The long-term efficacy of surgical correction of @entity3153 was evaluated in 45 consecutive @entity1 . Before surgery, 42 @entity1 had reciprocating @entity591 and 12 had @entity955 . The principal operative procedure was endocardial incision in 42 @entity1 , endocardial cryoablation in 2 @entity1 and epicardial cryoablation without dissection of the atrioventricular (AV) fat pad in 1 @entity1 . Two @entity1 had perioperative complications. One @entity1 had @entity548 that necessitated reoperation, and one had a right @entity64 with subsequent clearing of @entity51 . At postoperative electrophysiologic study, only the @entity1 who underwent epicardial cryoablation had conduction over an accessory connection. Two others had intermittent delta waves in the early postoperative period but no accessory connection conduction at electrophysiologic study. During a mean follow-up of 3.1 years, the @entity1 with ineffective cryoablation had recurrent @entity591 , and one other @entity1 had late recurrence of delta waves without @entity943 . Four other @entity1 had frequent palpitation, which was caused by @entity1165 in one. Seventeen @entity1 had occasional "skipped beats" without recurrence of @entity591 . Twelve of 13 @entity1 whose @entity943 limited employment before surgery returned to work after surgery. By actuarial analysis at 1, 2 and 3 years, all @entity1 were alive and 98% were free from @entity591 . Surgical correction of @entity3153 provides excellent long-term results with low morbidity. @entity1 who are disabled by @entity943 return to work after successful surgery. Delta waves may persist or recur without return of @entity943 . Minor postoperative episodes of palpitation are common and do not correlate with @entity591 .

title: Long-term follow-up after surgical correction of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebral stroke']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['premature ventricular complexes in three and sinus tachycardia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia', 'tachyarrhythmias', 'orthodromic tachycardia']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficit']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity3153 :: ('MESH:D014927', 'Disease') :: ['Wolff-Parkinson-White syndrome']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

answer: @entity3153 :: (MESH:D014927,Disease) :: ['Wolff-Parkinson-White syndrome']


abstract: BACKGROUND: Endothelial injuries regularly occur in @entity731 and during interventional therapies of the @entity432 . Disturbances in the endothelial integrity can lead to insufficient blood supply and bear the risk of @entity715 formation and acute @entity432 . At present, effective therapeutics to restore endothelial integrity are barely available. We analyzed the effect of pharmacological @entity33559 -inhibition by @entity12350 on endogenous progenitor cell-based endothelial regeneration via the SDF-1a/ @entity9843 -axis after acute endothelial damage in a @entity19 model of @entity130 . METHODS AND RESULTS: Induction of a defined endothelial injury was performed in the carotid artery of C57Bl/6 @entity19 which led to a local upregulation of SDF-1a expression. Animals were treated with placebo, @entity12350 or @entity12350 + @entity9019 . Using mass spectrometry we could prove that @entity12350 prevented cleavage of the chemokine SDF-1a. Accordingly, increased SDF-1a concentrations enhanced recruitment of systemically applied and endogenous circulating @entity9843 + progenitor cells to the site of @entity1317 followed by a significantly accelerated reendothelialization as compared to placebo-treated animals. Improved endothelial recovery, as well as recruitment of circulating @entity9843 + progenitor cells (CD133+, @entity11132 +), was reversed by @entity9843 -antagonization through @entity9019 . In addition, short-term @entity12350 treatment did not significantly promote @entity1373 . CONCLUSION: @entity12350 can accelerate endothelial regeneration after acute endothelial injury. @entity33559 inhibitors prevent degradation of the chemokine SDF-1a and thus improve the recruitment of regenerative circulating @entity9843 + progenitor cells which mediate local endothelial cell proliferation without adversely affecting vessel wall architecture.

title: Short-term inhibition of @entity33559 enhances endothelial regeneration after acute XXXX via enhanced recruitment of circulating progenitor cells.

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['neointimal or medial hyperplasia']

entities_list: @entity12350 :: ('MESH:C496398', 'Chemical') :: ['Sitagliptin']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusive disease', 'vascular occlusion']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['carotid injury']

answer: @entity1317 :: (MESH:D057772,Disease) :: ['arterial injury']


abstract: BACKGROUND: The impact of @entity2643 on ablation outcome in longstanding persistent @entity955 (LSPAF) @entity1 is not known yet. OBJECTIVE: The purpose of this study was to assess the effect of @entity2643 on procedural-outcomes in LSPAF @entity1 undergoing catheter ablation. METHODS: We enrolled 112 LSPAF @entity1 on @entity2643 and scheduled to undergo @entity955 ( @entity955 ) ablation. @entity1 were randomized to @entity2643 discontinuation 4 months before ablation (group 1, n = 56) and a control group (group 2, n = 56) in which ablation was performed without @entity2643 discontinuation. All @entity1 underwent pulmonary vein (PV) antrum and posterior wall isolation, defragmentation and extra PV triggers ablation. @entity1 were followed up for recurrence for 32    8 months post-ablation. Repeat procedures in all recurrent @entity1 were performed off @entity2643 . RESULTS: During ablation, @entity955 termination was more frequent in group 2 compared to group 1 [44 (79%) vs 32 (57%), P = .015]. After high-dosage @entity3044 , more non-PV triggers were disclosed in group 1 compared to group 2 (42 [75%] vs 24 [43%] respectively, P <.001). Group 2 had lower procedure, radiofrequency and fluoroscopy times compared to group 1 (2.7    1 vs 3.1    1 h, 69    13 min vs 87    11 min and 64    14 min vs 85    18 min respectively). At 32    8 month follow-up, on or off antiarrhythmic drug success rate was 37 (66%) in group 1 and 27 (48%) in group 2 (P = .04). During redo, new non-PV trigger sites were identified in group 2 @entity1 . CONCLUSION: Periprocedural continuous @entity2643 was associated with higher organization rate and lower radiofrequency ablation rate. However, masking non-PV triggers increased the late recurrence rate.

title: Effect of periprocedural @entity2643 on procedure outcome in longstanding persistent XXXX undergoing extended pulmonary vein antrum isolation: Results from a randomized study (SPECULATE).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: @entity3457 ( @entity3457 ) elicits activation sufficient for full development and originates from sperm head submembrane matrices. @entity3457 comprises discrete, @entity2483 (referred to here respectively as @entity3457 -I and -II) which are each necessary but not sufficient to activate oocytes. The @entity1605 , @entity3457 -I(m), becomes solubilized from the perinuclear matrix under reducing conditions (the @entity3457 transition) to generate @entity3457 -I(s). Although @entity460 transients likely play an important role in oocyte activation at fertilization, the question is open as to whether demembranated heads or @entity3457 -I(s) and/or @entity3457 -II can induce @entity460 transients. We now report that injection of demembranated sperm heads into @entity19 oocytes efficiently induced @entity141 oscillations. When injected independently, @entity3457 -I(s) and demembranated heads heated to 48 degrees C failed to generate @entity141 oscillations. However, co-injection of @entity3457 -I(s) and 48 degrees C-heated heads induced oscillations, mirroring their synergistic ability to activate oocytes. This suggests that @entity3457 -mediated activation proceeds via pathways resembling those at fertilization and provides the first direct evidence that multiple sperm components are required to induce @entity141 oscillations. We probed the @entity3457 -I(s) liberation at the center of this activation and show that in vitro it was sensitive to a profile of @entity563 protease inhibitors. These findings support a model in which @entity1 oocyte activation, including the induction of @entity460 transients, involves proteolytic processing of @entity3457 from sperm head submembrane compartments.

title: XXXX oocyte activation by the synergistic action of discrete sperm head components: induction of @entity460 transients and involvement of proteolysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['heat-sensitive SOAF component']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity2483 :: ('MESH:C566443', 'Disease') :: ['heat-sensitive and -stable components']

entities_list: @entity3457 :: ('OMIM:612348', 'Disease') :: ['Sperm-borne oocyte-activating factor', 'SOAF']

answer: @entity1 :: (9606,Species) :: ['Mammalian']


abstract: OBJECTIVE: To explore the relationship between histone acetylation modification in spleen @entity1961 (+)T cells and @entity2316 . METHODS: Non-obese @entity6 (NOD) @entity19 were randomly divided into 4 groups and random blood @entity413 at 12, 18, 24 and 30 weeks were detected. Urinary albumin and @entity1011 were detected by enzyme-linked immunosorbent assay (ELISA). The global acetylation levels of H3 and H4 in @entity1961 (+)T cells were measured by H3/H4 acetylation kit. The relevant mRNA expression level of histone acetylation modification enzymes was detected by real-time quantitative polymerase chain reaction (PCR) and the altered expression genes verified by Western blot. RESULTS: Compared with @entity19 from 12 weeks, there were significant increases in blood @entity413 levels and urinary albumin/ @entity1011 ratio (ACR) from 24 and 30 weeks ( @entity413 : (18.1    6.3) and (20.7    7.5) vs (7.2    3.1)mmol/L, ACR: (4.04    1.54) and (8.11    1.77) vs (2.12    0.56)mg/g). Conversely, the global acetylation levels of H3 (0.068    0.023 and 0.043    0.017 vs 0.127    0.036) and H4 (0.058    0.022 and 0.041    0.019 vs 0.082    0.032) in spleen @entity1961 (+)T cells from 24 and 30 weeks were obviously lower. The mRNA levels of such histone acetylases as P300 (15.53    6.31 and 13.76    3.62 vs 22.94    7.40) and @entity71852 ( @entity71852 ) (3.21    0.81 and 2.74    0.36 vs 5.31    0.73) declined while the protein and mRNA of @entity35594 ( @entity35594 ) significantly increased from 24 and 30 weeks. All the above differences were statistically significant (P < 0.05). The levels of H3 (r = -0.590, P = 0.043) and H4 (r = -0.702, P = 0.011) were negatively correlated with urinary ACR while @entity35594 level was positively correlated with urinary ACR from 24 and 30 weeks (r = 0.673, P = 0.016). CONCLUSIONS: With aging and progression of @entity8 in NOD @entity19 , the global acetylation levels of H3 and H4 decrease while the expression level of @entity35594 increases in spleen @entity1961 (+)T cell. And altered @entity35594 expression in spleen @entity1961 (+)T cells is closely correlated with @entity8 in NOD @entity19 .

title: [Relationship between histone acetylation modification in spleen XXXX (+)T cells and @entity2316 of nonobese @entity6 @entity19 ].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'kidney damage']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1961 :: (12504(Tax:10090),Gene) :: ['CD4']


abstract: UNASSIGNED: Astrocytomas are the most common and aggressive @entity1313 in @entity1 . Invasiveness of these @entity5 has been attributed in part to deregulation of cell motility-dependent cytoskeletal dynamics that involves actin-binding proteins such as @entity12386 . @entity1420 (P4) has been found to induce migration and invasion of cells derived from @entity0 and endothelium. However, the role of P4 in migration and invasion of @entity816 cells as well as its effects on @entity816 cytoskeleton remodeling is not known. In this work we evaluated these aspects in D54 and U251 cells derived from @entity1 @entity816 from the highest degree of @entity5 (grade IV, @entity463 ). Our results showed that in scratch-wound assays P4 increased the number of D54 and U251 cells migrating from 3 to 48h. Both @entity3927 , a P4 receptor (PR) antagonist, and an oligonucleotide antisense against PR significantly blocked P4 effects. Transwell assays showed that P4 significantly increased the number of invasive cells at 24h. As in the case of migration, this effect was blocked by @entity3927 . Finally, by Western blotting, an increase in the @entity12386 /p- @entity12386 ratio at 15 and 30min and a decrease at 30 and 60min in U251 and D54 cells, respectively, was observed after P4, P4+ @entity3927 and @entity3927 treatments. These data suggest that P4 increases @entity1 @entity816 cells migration and invasion through its intracellular receptor, and that @entity12386 activation by P4 is independent of PR action.

title: @entity1420 promotes cell migration, invasion and @entity12386 activation in XXXX @entity816 cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['Progesterone']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['primary brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumors']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytomas', 'astrocytoma']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVES: The complexity of @entity9292 is different in @entity1 with and without @entity30 and in @entity1 and @entity1 . This may affect the localization of the internal orifice. We compared the characteristics of @entity9292 and the accuracy of Goodsall's rule in predicting the position of the internal orifice in male and female @entity30 @entity1 . METHODS: A total of 191 @entity292 tracks in 182 consecutive @entity1 (110 @entity1 and 72 @entity1 ) were analyzed prospectively. Of the @entity1 , 63 were diagnosed with @entity30 . The positions of the orifices were recorded and the accuracy of Goodsall's rule determined. RESULTS: The distribution of @entity292 subtypes among @entity30 @entity1 differed significantly (p = 0.0471). Fistulas with an anterior external opening occurred more frequently in @entity30 @entity1 (p = 0.0350) and in @entity1 (p = 0.0030). Fistulas with a posterior external orifice were observed more frequently in non- @entity30 @entity1 (p = 0.0350) and in @entity1 (p = 0.0028). Overall, Goodsall's rule performed less well in @entity1 compared with @entity1 (p = 0.0633). The accuracy of Goodsall's rule overall was not affected by @entity30 . In female non- @entity30 @entity1 , the positive predictive value of a posterior external orifice was lower than in @entity1 (p = 0.0406). CONCLUSIONS: The distribution of @entity292 subtypes and the ratio of anterior and posterior external openings among @entity30 @entity1 differ significantly. @entity292 defy Goodsall's rule, particularly in @entity1 and when applied to fistulas with anterior external orifices. The popular rule, however, falls equally short in @entity30 .

title: Do XXXX in @entity30 behave differently and defy Goodsall's rule more frequently than fistulas that are cryptoglandular in origin?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity9292 :: ('MESH:D012003', 'Disease') :: ['anal fistulas']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['Many fistulas', 'fistula']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's and non-Crohn's", "Crohn's and non-Crohn's fistulas", "Crohn's", "Crohn's disease"]

answer: @entity9292 :: (MESH:D012003,Disease) :: ['anal fistulas']


abstract: The @entity99 Prevention Board (VHPB) believes that stronger action is needed to control @entity1956 . Vaccinating those identified as at 'high risk' has failed to make a significant impact on the epidemiology of the disease. Many @entity1 with @entity1956 do not fall into any of the 'classic' high-risk groups and efforts to reach these groups have been unsuccessful. The VHPB supports the recommendation of the World Health Organization (WHO) that @entity1956 vaccine should be incorporated into national universal vaccination programmes by 1997. The recommendation came initially from the Global Advisory Group of the Expanded Programme on Immunization and was endorsed in 1992 by the World Health Assembly, the governing body of WHO which consists of representatives of all WHO member states. The WHO Working Group on the control of @entity99 in Europe, which met in Munich in 1991, concluded that the routine immunization of @entity1 and adolescents should receive the highest priority. Universal @entity1 and adolescent strategies have their own benefits and drawbacks; the VHPB has looked carefully into the rationale for and against these strategies. The prerequisites for implementing these strategies are discussed. A combined @entity1 and adolescent strategy emerges as having many of the advantages of the individual approach and fewer disadvantages. Universal vaccination is clearly the most effective strategy for preventing @entity1956 . Its timely and successful implementation, even in countries with medium and low prevalence, is a priority. There is no reason why @entity1956 should not follow the success of @entity14333 , polio, diphtheria and measles vaccination.

title: VHPB: summary of strategies and recommendations. XXXX Prevention Board.

entities_list: @entity1 :: ('9606', 'Species') :: ['infants', 'people', 'infant']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['Viral Hepatitis', 'viral hepatitis']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

answer: @entity99 :: (MESH:D056486,Disease) :: ['Viral Hepatitis']


abstract: INTRODUCTION: @entity795 is a congenital @entity7881 . This @entity2526 involves the skeletal system, soft tissues, skin and vascular system. The most likely pathogenesis involves somatic mosaicism. Main manifestations included soft-tissue and @entity7174 , partial @entity11125 , @entity11122 , exostoses, @entity362 and @entity455 . The most common @entity75 are hemimegencephaly and @entity74 . We present a case of @entity795 with @entity455 which are not described previously. CLINICAL CASE: Our @entity1 is a 61 year-old male who has @entity1184 of the four limbs, @entity41163 and @entity1184 of chest and abdomen asymmetric with mild @entity7439 . Prominent and abundant of the four extremities and trunk, also asymmetric. @entity5 in the skin of trunk and left limb. Cerebral MRI shows @entity6623 and @entity600 . CONCLUSION: Clinical diagnostic criteria of @entity795 are documented in our @entity1 . He also has @entity2457 which are not described previously in the literature. We consider that both findings are not a product of causality due to the high prevalence of @entity1317 malformations in these @entity1 . We hypothesize that a single mutation, probably involving genes in relation with apoptotic control will be responsible of @entity795 and @entity455 in our @entity1 , due to a defect of angiogenesis.

title: [ @entity795 with XXXX ].

entities_list: @entity11122 :: ('MESH:C563014', 'Disease') :: ['hemihypertrophy']

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['cerebral vascular anomalies', 'vascular anomalies']

entities_list: @entity795 :: ('MESH:D016715', 'Disease') :: ['Proteus syndrome']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormalities']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Vascular tumors']

entities_list: @entity7174 :: ('MESH:D009506', 'Disease') :: ['epidermal nevi']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['multiple cavernous malformations']

entities_list: @entity2526 :: ('MESH:D025063', 'Disease') :: ['sporadic disorder']

entities_list: @entity6623 :: ('MESH:D020787', 'Disease') :: ['venous angiomas']

entities_list: @entity2457 :: ('MESH:D020785', 'Disease') :: ['brain vascular malformations']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['migrational disorders']

entities_list: @entity41163 :: ('MESH:C562546', 'Disease') :: ['macrodactyly']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['systemic vascular hamartomatous']

entities_list: @entity7881 :: ('MESH:C563621', 'Disease') :: ['hamartomatous dysplasia']

entities_list: @entity7439 :: ('MESH:D005146', 'Disease') :: ['facial asymmetry']

answer: @entity2457 :: (MESH:D020785,Disease) :: ['cerebral vascular malformations']


abstract: Angioplasty for occluded coronary arteries is less successful than for sub-total stenoses. The Magnarail system (Schneider) has been designed to improve success rates. We used the system in 112 @entity1 with @entity1563 (TIMI flow < or = 1) which the operator felt suitable for angioplasty. It was successful (defined as < 50% stenosis) in 75.9% overall, 65.9% in occlusions > 3 months and 83.3% < 3 months. Intimal dissection occurred in 26 instances, more commonly after right coronary angioplasties. One @entity1 died and one procedure was complicated by coronary perforation treated surgically. The procedure was less successful in the right coronary artery (p = 0.02). Coronary calcification (p = 0.03), the absence of a @entity432 (p = 0.04) and the absence of collaterals from another vascular territory (p = 0.04) were all associated with angiographic failure. The mean fluoroscopy time for the procedures was 22.8 +/- 16.9 minutes. The Magnarail system seems highly effective in recanalization of @entity1563 .

title: Recanalization of XXXX using the Magnarail system: technique and procedural outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary occlusions']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['tapered occlusion']

answer: @entity1563 :: (MESH:D054059,Disease) :: ['coronary occlusions']


abstract: UNASSIGNED: An association of human @entity4107 alleles with autoimmune conditions is increasingly being used for diagnostic purposes. The aim of our study was to examine whether HLA class II alleles in pediatric-onset @entity409 (pAILD) may serve as diagnostic markers and if they correlate with clinical outcome parameters. @entity1533 alleles of 76 @entity1 with pAILD ( @entity775 [ @entity775 ], @entity792 [ @entity792 ], @entity991 [ @entity991 ]) and of 50 healthy blood donors as control group were analyzed retrospectively. Diagnosis of these @entity1 was confirmed by the @entity775 score including liver histology, which has been re-evaluated by a blinded liver pathologist, and by bile duct imaging, as appropriate. Our results showed significant association of @entity1533 *03 with @entity49429 and @entity792 with 82  % specificity for @entity775 . For pAILD (excluding @entity5698 ), @entity1533 *03 homozygosity had specificity of 98  %, whereas sensitivity is low. Remission in @entity1533 *03-positive @entity1 appears to be less likely. @entity1533 *13 is significantly associated with @entity991 and also with @entity49429 . CONCLUSION: @entity1533 alleles provide supportive information for diagnostic workup in @entity1 with @entity409 , but they were not suitable for differentiation within pAILD. Their prognostic value could be helpful but needs to be evaluated further. What is Known:     @entity1533 *03 is NOT associated with pediatric @entity775 in a previous national study.     In other studies, @entity1533 *03 is associated with @entity49429 .     @entity1533 *13 is associated with @entity991 .     @entity1533 *04 is described as protective for AILD. What is New:     @entity1533 four-digit typing for all alleles and for all subgroups of pAILD combined with re-assessment of liver histology     @entity1533 *03:01 is associated with pediatric @entity49429 and @entity792 .     @entity1533 *03:01 appears to be a prognostic marker.     @entity1533 *13:01 is associated with pediatric @entity49429 in mixed ethnicity cohort.     @entity1533 *04 does not show any protective effect for pAILD.

title: Human leucocyte antigens and pediatric XXXX : diagnosis and prognosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease', 'autoimmune liver disease']

entities_list: @entity991 :: ('MESH:D015209', 'Disease') :: ['PSC', 'primary sclerosing cholangitis']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['AISC', 'autoimmune sclerosing cholangitis']

entities_list: @entity4107 :: ('3126', 'Gene') :: ['leukocyte antigen (HLA) class II']

entities_list: @entity775 :: ('MESH:D019693', 'Disease') :: ['AIH', 'autoimmune hepatitis']

answer: @entity409 :: (MESH:D008107,Disease) :: ['autoimmune liver disease']


abstract: Experimental chemotherapy with @entity1466 transplanted in @entity19 has been studying to improve the prognosis of drug resistant @entity1466 . In this paper the characteristics of transplanted @entity5 were presented. Two @entity5 , CC-HM-I (HM) and @entity71234 ( @entity71234 ), were used. The characteristics of the @entity5 were studied in macroscopical findings, histological findings, growth curves, DNA amount analysis, LDH activity, alkaline phosphatase activity, and their isozyme patterns. Both @entity5 well maintained the characteristics of original and/or the beginning ones. Some differences between two @entity5 were pointed out. In morphology, HM was yellowish and hard @entity5 and the growth rate was rather slow. While, @entity71234 was dark and soft @entity5 and contained a lot of bleeding and @entity39 tissue. Its growth rate was quick and all of @entity19 with @entity71234 died of @entity5 around 50 days after transplantation. The serum level of HCG of HM was 75.8 +/- 2.8 ng/ml/g @entity5 and that of @entity71234 was 117.4 +/- 6.2 ng/ml/g @entity5 . The good correlation between the @entity5 weight and the serum level of HCG was obtained in both groups. The activities of LDH and alkaline phosphatase in the tissues of @entity71234 were about 3 times as higher as the one of HM. It was confirmed that the transplanted @entity1466 in @entity19 was useful model for the study the nature of @entity1 @entity1466 and it will contribute to the establishment of the rational chemotherapy for drug resistant @entity1466 .

title: [Characteristics of @entity1 XXXX transplanted in @entity19 (author's transl)].

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity1466 :: ('MESH:D002822', 'Disease') :: ['choriocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

answer: @entity1466 :: (MESH:D002822,Disease) :: ['choriocarcinoma']


abstract: OBJECTIVE: The aim was to gain knowledge of @entity239 ( @entity239 ) @entity1 on long-term sick leave and with particular difficulties in resuming work, and to compare them with @entity1 with @entity925 , back or joint diagnoses, and @entity308 . METHODS: @entity1 were identified by and referred from social insurance offices and were multidisciplinarily examined by three board-certified specialists in psychiatry, orthopedic surgery and rehabilitation medicine. Ninety-two @entity1 were diagnosed with @entity239 only. Three female comparison groups were chosen: @entity308 , back/joint diagnoses, and @entity925 . RESULTS AND CONCLUSIONS: Ceaseless @entity158 was reported by 73% of @entity239 @entity1 , 54% of back/joint diagnoses @entity1 , 43% of @entity925 @entity1 , and 35% of @entity308 @entity1 . The distribution of @entity158 (>50%) in @entity239 @entity1 was to almost all regions of the body, and in @entity308 @entity1 to the lower dorsal neck, upper shoulders and lumbosacral back but not in the anterior body. Reduced sleep was more evident in @entity239 @entity1 . @entity239 @entity1 did not meet more criteria for @entity1314 than @entity1 with the other @entity158 conditions. The most common dimension of "personality traits" of @entity158 conditions was the "obsessive compulsive" but at a level clearly below that indicating a @entity1314 . More @entity239 @entity1 experienced disabilities, the most common being in the mobility and domestic-life areas.

title: Long-term sick-leavers with XXXX : Comparing their multidisciplinarily assessed characteristics with those of others with chronic pain conditions and @entity308 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia', 'FM']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['somatic pain', 'pain']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality disorder']

answer: @entity239 :: (MESH:D005356,Disease) :: ['fibromyalgia']


abstract: Recently, we reported that recombinant interferon-alpha (rIFN-alpha) can induce hematologic remissions and cytogenetic improvement in newly diagnosed Philadelphia (Ph)-positive @entity1860 ( @entity1860 ) @entity1 . Although @entity379 is a structurally distinct molecule, this agent suppresses in vitro hematopoietic progenitor cells in a fashion similar to that of @entity3027 . Therefore, we initiated a study of @entity3692 at doses of 0.25 to 0.5 mg/m2/d intramuscularly in @entity1 with Ph-positive benign-phase @entity1860 . Twenty-six of 30 @entity1 entered in the study were evaluable. Six @entity1 have achieved a complete hematologic response; four, a partial hematologic response. The median follow-up period of @entity1 who are in complete remission is 7.5 months (range, 5 to 12 months). No relapses have occurred among the complete responders. So far, five @entity1 have had cytogenetic improvement with emergence of 5% to 45% diploid cells in the bone marrow. @entity221 and flulike symptoms were the most common side effects, with partial tolerance often developing after about 1 week. The majority of @entity1 tolerated therapy with minimal change in performance status. In conclusion, @entity3692 has demonstrated clinical activity in @entity1860 . On the basis of these observations and the in vitro synergistic growth-inhibitory effects of @entity3027 and @entity379 , we have started trials of combination IFN therapy in @entity1860 @entity1 .

title: Therapy of @entity1860 with recombinant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myelogenous leukemia']

answer: @entity379 :: (3458,Gene) :: ['interferon-gamma']


abstract: AIMS: Incidence of primary @entity4617 (PCTs) is not known. Literature data derive from autoptic studies or echocardiographic registries. An incidence of 1 of 1000 autoptic and 1.5 of 1000 echocardiographic study is reported but data from a general population are not available. The aim of our study was to evaluate the incidence rate of PCTs in the general population. METHODS: All @entity1 with suspected cardiac mass were evaluated with basal echocardiogram and/or transesophageal echocardiogram/cardiac magnetic resonance by Grosseto's cardiology department, the county referral center for both adult and pediatric populations. Diagnosis was confirmed at surgical excision (32), autoptic specimens (3) or by multimodal imaging when surgery was not indicated (7). The database of the county health system was interrogated to identify residents with The International Classification of Diseases-9 codes of @entity10921 . Forty-two consecutive cases of PCTs were diagnosed from 1 January 1998, through 31 December 2011, among residents in Grosseto's county. RESULTS: Incidence rate of PCTs was 1.38 of 100000 inhabitants per year. PCTs were benign in 38 @entity1 (90.5%) and malignant in four (9.5%). Twenty @entity3291 were found (48%), followed by seven fibroelastomas (15%), six @entity362 (15%), three @entity4618 (8%), two @entity2695 (5%), two @entity242 (5%), one @entity706 (2%) and one @entity2698 (2%). Incidence of benign @entity10921 was 1.24 of 100000/year; referring only to @entity3291 we found an incidence of 0.68 of 100000/year. CONCLUSION: This is the first population study on @entity10921 , a @entity395 with an incidence rate of 1.38 new cases per 100,000 residents per year.

title: Incidence rate of primary XXXX : a 14-year population study.

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcomas']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity2698 :: ('MESH:D006393', 'Disease') :: ['pericardial hemangiopericytoma']

entities_list: @entity4617 :: ('MESH:D006338', 'Disease') :: ['cardiac tumors']

entities_list: @entity4618 :: ('MESH:D012207', 'Disease') :: ['rhabdomyomas']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disease']

answer: @entity4617 :: (MESH:D006338,Disease) :: ['cardiac tumors']


abstract: OBJECTIVE: This study explored the value of preoperative self-reported assessment for @entity308 and @entity148 in @entity1 who had undergone heart transplantation (HTx). The initial sample was divided into subgroups of @entity1 with @entity63 (ICMP) and @entity384 ( @entity384 ). @entity1 @entity308 and @entity148 scores were measured in both subgroups and their impact on pre- and postoperative mortality investigated. METHOD: An initial sample of 152 @entity1 with either ICMP (N = 57) or @entity384 (N = 95) and end-stage @entity299 awaiting heart transplantation were assessed in a multidimensional longitudinal study, including psychological and somatic variables. One hundred and three @entity1 received a HTx and were followed up for a mean of 4.4 years. Proportional hazard models were computed to test for the influence of psychosocial and somatic factors on outcome. RESULTS: Preoperative @entity308 and state @entity148 scores were significantly higher in the ICMP group. In addition to donor and recipient age, ICMP @entity1 in the preoperative high @entity308 group also showed a significantly higher mortality after HTx. This result remained significant even after controlling for sociodemographic and somatic variables. CONCLUSIONS: @entity1 self-reported @entity308 , but not @entity148 , can contribute to the identification of subgroups of @entity1 with an unfavorable outcome after HTx. It therefore may be helpful to screen for @entity308 , particularly in @entity1 with an @entity63 cause of their end-stage @entity299 . Specific intervention programs should be further developed and evaluated.

title: Effect of XXXX on survival after heart transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['DCMP', 'dilated cardiomyopathy']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: SETTING: Machakos District, Kenya, a rural area 50 km east of Nairobi. OBJECTIVE: To assess the cost and cost-effectiveness of new treatment strategies for @entity378 @entity1 , involving decentralisation of care from hospitals to peripheral health units and the community, compared to the conventional approaches to care used until October 1997. METHODS: Costs were analysed in 1998 US dollars from the perspective of health services, @entity1 , family members and the community, using standard methods. Separate analyses were undertaken for 1) new smear-positive pulmonary @entity1 and 2) new smear-negative and extrapulmonary @entity1 . Cost-effectiveness was calculated as the cost per @entity1 successfully completing treatment (smear-positive cases) and as the cost per @entity1 completing treatment (new smear-negative and extra-pulmonary cases). FINDINGS: The cost per @entity1 treated for new smear-positive @entity1 was dollars 591 with the conventional hospital-based approach to care, and dollars 209 with decentralised care. Costs fell from all perspectives, and by 65% overall. Cost-effectiveness improved by 66%. The cost per @entity1 treated for new smear-negative/extra-pulmonary @entity1 was dollars 311 with the conventional approach to care, and dollars 197 with decentralised care. Costs fell from all perspectives, and cost-effectiveness improved by 61%. CONCLUSION: There is a strong economic case for expansion of decentralisation and strengthened community-based care in Kenya. The National @entity378 and Leprosy Control Programme will require new funds for start-up training and community mobilisation costs in order to do this.

title: Cost and cost-effectiveness of increased community and primary care facility involvement in XXXX care in Machakos District, Kenya.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['Tuberculosis', 'tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['tuberculosis']


abstract: The cerebellum is implicated in maintaining the saccadic subsystem efficient for vision by minimizing movement inaccuracy and by learning from endpoint errors. This ability is often disrupted in @entity76 , as demonstrated by saccade @entity854 . The study of saccades in these @entity1 may therefore provide insights into the neural substrate underlying saccadic motor control. We investigated the different extent of saccade @entity854 in @entity196 and @entity32889 @entity6447 , genetically undefined and with prevalent @entity76 . Reflexive and voluntary saccades of different amplitude (10  -18  ) were studied in seven @entity1 with @entity196 , eight @entity1 with @entity32889 @entity6447 and 25 healthy controls. Quantitative analysis of saccade parameters and measures of saccade accuracy were performed. Detailed neurological, neurophysiological and magnetic resonance imaging assessment was obtained for each @entity1 . Genetic and laboratory screening for @entity164 and other forms of @entity32889 @entity6447 were also performed. A lower peak saccade velocity and longer duration was observed in @entity1 with @entity196 with respect to those with @entity32889 @entity6447 and controls. Unlike subjects with @entity196 , @entity1 with @entity32889 @entity6447 showed main sequence relationships to similar saccades made by normal subjects. Saccades were significantly more inaccurate, namely hypometric, in @entity32889 @entity6447 than in @entity196 and inaccuracy increased with saccade amplitude. The percentage of hypometric primary saccades and of larger secondary corrective saccades were consistently higher in @entity32889 @entity6447 than in @entity196 and controls. No other significant differences were found between groups. Two different mechanisms were adopted to redirect the fovea as fast and/or accurately as possible to peripheral targets by the two groups of cerebellar @entity1 . @entity1 with @entity196 maintained accuracy using slow saccades with longer duration. This reflects prevalent degenerative processes affecting the pontine burst generator and leading to saccade velocity failure. On the other hand, @entity1 with @entity32889 @entity6447 reached the target with a number of fast inaccurate, mostly hypometric saccades. Different degrees of cerebellar oculomotor vermis involvement may account for differences in optimizing the trade-off between velocity and accuracy in the two groups. In addition, as suggested by spinocerebellar @entity1 having slow saccades that are no longer ballistic, visual feedback might be continuously available during the movement execution to guide the eye to its target.

title: Differences in saccade dynamics between @entity196 and @entity32889 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['spinocerebellar ataxia 2', 'spinocerebellar ataxia type 2']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['dynamic abnormalities', 'kinetic abnormalities']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['cerebellar atrophy', 'degenerative cerebellar diseases']

entities_list: @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar ataxias', 'cerebellar ataxia']

entities_list: @entity164 :: ('MESH:D017827', 'Disease') :: ['spinocerebellar ataxias']

answer: @entity6447 :: (MESH:D002524,Disease) :: ['cerebellar ataxias']


abstract: OBJECTIVE: To provide results from the largest study of new daily persistent @entity10 @entity1 to date and specifically evaluate if @entity1 with primary new daily persistent @entity10 develop @entity62 or @entity1188 on neuroimaging. METHODS: Retrospective analysis of @entity1 medical records utilizing an electronic medical record system. All @entity1 were seen at a @entity10 specialty clinic by a single @entity10 neurologist and diagnosed with primary new daily persistent @entity10 during the time period of January 2009 to January 2013. RESULTS: Altogether, 97 @entity1 were diagnosed with primary new daily persistent @entity10 (65 @entity1 and 32 @entity1 ). The mean average age of onset was slightly younger in @entity1 than @entity1 : 32.4 years vs. 35.8 years. In total, 84 of the 97 new daily persistent @entity10 @entity1 had no @entity62 or @entity1188 on magnetic resonance imaging with a gender distribution of 56 @entity1 and 28 @entity1 . The mean age of onset of this white matter negative subgroup was 31.1 years. Of these individuals, 36% had cardiovascular/cerebrovascular risk factors and 44% had a history of @entity2704 . Only 13 new daily persistent @entity10 @entity1 (nine @entity1 , four @entity1 ) demonstrated @entity62 on magnetic resonance imaging. None had @entity1188 . The mean age of onset of this white matter positive subgroup was 54.2 years, significantly older than the white matter negative population (p   <   .05). All new daily persistent @entity10 @entity1 in the white matter positive subgroup had cardiovascular/cerebrovascular risk factors and dual risk factors were noted in seven of 13 @entity1 . Only 23% had a @entity2704 history. Almost 40% of the @entity1 in the white matter negative group were imaged 3 years after @entity10 onset and at least six @entity1 were imaged at least 9 years or more after onset of new daily persistent @entity10 . Triggering events in both @entity62 positive and negative populations were typical of the new daily persistent @entity10 population as a whole and not specific to the presence or absence of brain imaging lesions except for a post-surgery trigger, which was significantly more likely to occur in the white matter positive group. @entity2704 associated symptoms occurred in 77% of the white matter negative subgroup compared with 46% of the white matter positive subgroup, which was a significant difference. CONCLUSION: @entity62 and @entity1188 do not appear to occur in primary new daily persistent @entity10 @entity1 . Only new daily persistent @entity10 @entity1 with risk factors (cardiovascular/cerebrovascular or @entity2704 ) developed @entity62 on brain magnetic resonance imaging. No @entity1 with new daily persistent @entity10 developed @entity1188 . New daily persistent @entity10 triggering events (outside of possibly post-surgery) or the presence of @entity2704 did not appear to enhance the development of @entity62 .

title: New daily persistent XXXX : A lack of an association with @entity62 on neuroimaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'Migraine', 'migrainous symptoms']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct-like lesions']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['White matter abnormalities', 'white matter lesion', 'white matter abnormalities']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity10 :: (MESH:D006261,Disease) :: ['headache']