abstract: UNASSIGNED: @entity14537 ( @entity14537 , @entity19277 #117550) is an @entity21117 . Deletions or intragenic mutations of the @entity14538 , which is located at chromosome 5q35, are responsible for more than 75% of @entity14537 . Conventionally, @entity4053 was reported briefly as one of the infrequent symptoms of @entity14537 . However, Matsuo et al. published a report describing five @entity1 with @entity14537 who presented with transient @entity1717 ( @entity1717 ) in the neonatal period. We report on an additional @entity1 of @entity14537 , who presented transient @entity1717 in the neonatal period. All of this @entity1 and previous @entity1 have microdeletions at the 5q35 chromosome. Therefore, we examined the following three in considering the possibility that other factor than @entity14538 caused @entity1717 . 1) This @entity1 had no mutation of four currently known @entity1717 related genes, @entity11773 , @entity14225 , @entity29521 , and GCK. 2) He had no further deletion than commonly observed region encompassing @entity14538 by comparative genomic hybridization to DNA microarrays. 3) He had no mutation in the 5q35 region in the non-deleted chromosome using exsome sequence analysis. In conclusion, our @entity1 supported that @entity1717 could be one of the characteristic symptoms of @entity14537 in the neonatal period, and could be useful for early diagnosis.    2015 Wiley Periodicals, Inc.

title: A case with neonatal XXXX : It is a characteristic complication of sotos syndrome.

entities_list: @entity14537 :: ('MESH:D058495', 'Disease') :: ['SoS', 'Sotos syndrome']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['neonatal hypoglycemia']

entities_list: @entity1717 :: ('MESH:D044903', 'Disease') :: ['HIH', 'hyperinsulinemic hypoglycemia']

entities_list: @entity21117 :: ('MESH:C537340', 'Disease') :: ['overgrowth syndrome']

answer: @entity1717 :: (MESH:D044903,Disease) :: ['hyperinsulinemic hypoglycemia']


abstract: AIMS: Measurements of the tensile and bending strength of samples of vaginal tissue collected during corrective surgery of prolapse. MATERIALS AND METHODS: Our measurements were conducted on two samples of vaginal tissue 2 cm x 2 cm collected during surgical correction of prolapse by vaginal route in 16 post-menopausal @entity1 . The samples were collected from posterior vaginal fundus, were orientated, and then fixed on a plate holding the edges and allowing the tissue to be stretched over an orifice of 1 cm. The tensile measurements were made using a suture passed over this distance of 1 cm in one of the two samples by recording the strength curve in order to evaluate the force at @entity397 of the collagen fibres. The second sample was prepared in the same way and a piston of 1 cm diameter was made to penetrate to determine the strength of breakage of the fibres. The pressure and tensile strength curves were recorded up to @entity397 of the sample, as was the value of the tissue elongation. RESULTS: There was a great variability in the measurements of maximum strength at @entity397 of the vaginal samples and in the elongation before @entity397 of the samples. The mean @entity397 values in tensile tests were 44 and 59 N in bending with extremes of 12 and 130 N. The values of elongation before @entity397 of a 10 mm sample were 23 mm in tensile tests and 11 mm in bending tests. There was a great variability of results from one @entity1 to another. There was no relation between the values observed and the @entity1 age. There was a statistical relation between the elongation values of the samples and the maximum force before @entity397 in both the tensile and bending tests. There was also a relation between the measurement of the maximum force at @entity397 in bending and in tensile tests although there was no such relation in terms of the values of elongation before @entity397 . DISCUSSION: There is no published reference concerning the strength at @entity397 or the tensile strength curves for @entity1 vaginal tissues. Vaginal tissues are however commonly used as a suspension component in the vast majority of operations for correcting prolapse or @entity322 . These suspensions are made by passing a suture through the thickness of the vaginal tissue. The results that we report do however show that these vaginal tissues are very variable in strength from one @entity1 to another. The same finding was made in terms of the elongation values for the vaginal tissue before @entity397 . The values in bending tests showed that the highest @entity397 force values and the greatest mean elongation before @entity397 were lower than in tensile tests. CONCLUSIONS: These findings could explain some failures of these surgical procedures, which are all based on the tensile strength properties. Finally these results could be included in modelling of the reaction of vaginal tissues to the pressure experienced within the vagina.

title: A biomechanical study of the strength of vaginal tissues. Results on 16 post-menopausal XXXX presenting with genital prolapse.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A sanitary-chemical study on three kinds textile materials with different percentage content of @entity8607 silk (PAS) was carried out. Migration of chemicals was studied - low molecular compounds of @entity12773 (LMC) and @entity24924 in water extracts of the patterns tested. Thin layer chromatographic and spectrophotocalorimetric methods were employed. The summed up content of LMC of @entity12773 was established in the first extracts of 5.0 to 7.0 mg/l for the various kinds of cloth, their proper separation in monomers, dimers, trimers, etc. oligomers being attained by the thin layer chromatographic investigation. Monomer content in the first extracts reaches to 1.15 mg/l, decreasing in the following ones to complete disappearing. At the same time dimers, trimers, etc. oligomers content of @entity12773 progressively increases. The presence of @entity24924 and optical bleachers is established in the extracts investigated. The attention of the producers is drawn to a stronger control, still under production conditions, for washing out the residual quantities of non-polymerized oligomers and other chemicals of synthetic @entity8607 materials, aiming at ensuring harmless and biologically inert clothes.

title: [Migration of chemical substances out of XXXX textile materials].

entities_list: @entity12773 :: ('MESH:D002209', 'Chemical') :: ['caprolactam']

entities_list: @entity8607 :: ('CHEBI:61445', 'Chemical') :: ['polyamide']

entities_list: @entity24924 :: ('MESH:C009546', 'Chemical') :: ['triethanolamine']

answer: @entity8607 :: (CHEBI:61445,Chemical) :: ['polyamide']


abstract: BACKGROUND: Growing interest in multimorbidity is observable in industrialized countries. For Germany, the increasing attention still goes still hand in hand with a small number of studies on multimorbidity. The authors report the first results of a cross-sectional study on a large sample of policy holders (n = 123,224) of a statutory health insurance company operating nationwide. This is the first comprehensive study addressing multimorbidity on the basis of German claims data. The main research question was to find out which @entity102 and disease combinations are specific to multimorbidity in the elderly. METHODS: The study is based on the claims data of all insured policy holders aged 65 and older (n = 123,224). Adjustment for age and gender was performed for the German population in 2004. A @entity1 was defined as multimorbid if she/he had at least 3 diagnoses out of a list of 46 chronic conditions in three or more quarters within the one-year observation period. Prevalences and risk-ratios were calculated for the multimorbid and non-multimorbid samples in order to identify diagnoses more specific to multimorbidity and to detect excess prevalences of multimorbidity patterns. RESULTS: 62% of the sample was multimorbid. @entity1 in general and @entity1 receiving statutory nursing care due to disability are overrepresented in the multimorbid sample. Out of the possible 15,180 combinations of three chronic conditions, 15,024 (99%) were found in the database. Regardless of this wide variety of combinations, the most prevalent individual chronic conditions do also dominate the combinations: Triads of the six most prevalent individual chronic conditions ( @entity101 , @entity4977 , @entity1643 , @entity6 , @entity571 and @entity741 ) span the disease spectrum of 42% of the multimorbid sample. Gender differences were minor. Observed-to-expected ratios were highest when @entity10043 / @entity7391 metabolism disorders/ @entity210 and @entity571 were part of the multimorbidity patterns. CONCLUSIONS: The above list of dominating chronic conditions and their combinations could present a pragmatic start for the development of needed guidelines related to multimorbidity.

title: Which XXXX and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Women', 'person']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['chronic low back pain']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

entities_list: @entity4977 :: ('MESH:D052439', 'Disease') :: ['lipid metabolism disorders']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['chronic ischemic heart disease']

entities_list: @entity7391 :: ('MESH:C030986', 'Chemical') :: ['pyrimidine']

answer: @entity102 :: (MESH:D002908,Disease) :: ['chronic diseases']


abstract: OBJECTIVES: To investigate whether whole-body reaching (WBR) could be a task with adequate and gradable dynamic balance challenges for @entity64 @entity1 . DESIGN: A total of 23 subjects with @entity1158 , after their first @entity64 , participated in this study. The degree of dynamic balance challenges of WBR was graded by varying the distance to the targets that the subjects had to reach. A foot-pressure measurement system was used to measure the amount of center-of-pressure shift during performance of WBR and sit-to-stand transfer. The @entity2653 ( @entity2653 ) was administered, and the @entity2653 total score was calculated. Static and dynamic @entity2653 subscores were separately calculated to further understanding of the subject performance regarding balance. Paired t tests were used to examine the effects of target distance on center-of-pressure shift. Correlations between measures of center-of-pressure shift during performance of WBR and of sit-to-stand transfer, @entity2653 total score, @entity2653 static subscores, and @entity2653 dynamic subscores and measures of center-of-pressure shift during performance of sit-to-stand transfer were analyzed. RESULTS: Significant effects of distance on three of the variables representing amount of center-of-pressure shift were found (P < 0.05). The correlations between WBR and sit-to-stand transfer were positive and moderate. The correlations between WBR and sit-to-stand transfer were stronger when the subjects were reaching for a closer target than when reaching for a farther target. The correlations between WBR and @entity2653 total score were weak to moderate; the correlations between WBR and three scores of the @entity2653 across target distance were inconsistent; and the correlations were higher when the subjects were reaching for a farther target than when reaching for a closer target. CONCLUSIONS: WBR for targets at different distances imposed graded dynamic balance challenges on @entity64 @entity1 and might be an appropriate dynamic balance measure. However, WBR, as applied in this study, showed limitations in measuring the lateral dynamic stability of @entity64 @entity1 .

title: Whole-body reaching as a measure of dynamic balance in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2653 :: ('MESH:C538175', 'Disease') :: ['BBS', 'Berg Balance Scale']

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: Alterations in the microcirculation and parenchymal cell loss are common phenomena after irradiation of different organs. Whether parenchymal cell loss is a process well dissociated from vasculoconnective damage, or a consequence of this, is much debated. However, comprehensive radiopathological studies have shown that vasculoconnective tissue is an important common target for late effects in various organs. Scoring of skin @entity8721 was used by us as a clinical assay of late tissue effects after different dose schedules. All studies were done prospectively with standardized skin area, field size and radiation quality. The @entity1 were scored regularly up to 10 years. The number of @entity1 at risk for a prescribed score versus time was calculated with the life-table method. The late effects after 5 X 2.0 Gy/wk, in the dose range 40 to 70 Gy and after 2 X 4.0 Gy/wk, in the dose range 40 to 56 Gy have been established. The skin dose is 90% of the referred dose. Dose-response curves, relating the proportion of @entity1 with a certain score at a fixed time and radiation dose and dose-latency curves, relating the latent period for a fixed proportion of @entity1 with a certain score and radiation dose, were constructed. The analysis shows that: ED10/5 yr and ED50/5 yr for 5 X 2.0 Gy/wk is 50 Gy and 65 Gy, respectively, for distinct @entity8721 ; The latent period, concerning both a certain frequency and degree of reaction, varies exponentially with dose level; The latent period for 50% of the @entity1 , to obtain a certain score, LP50, is correlated to that for 10%, LP10, with LP50/LP10 = 2.2 +/- 0.2 (S.D.). This correlation is independent of score, total dose, and fractionation; Isoeffective doses for 5 X 2.0 Gy/wk and 2 X 4.0 Gy/wk, determined from the dose-response curves, resulted in the repair exp N between 0.31 and 0.32 and alpha/beta ratio between 2.9 and 3.1 Gy and determined from the dose-latency curves in exp N between 0.30 and 0.32 and alpha/beta ratio between 3.4 and 2.9 Gy. In conclusion, frequent and careful follow-up with registration of normal tissue reactions, until at least 10% of the @entity1 have obtained the prescribed effect, is predictive for the further progression of the late effects. The fractionation characteristics for @entity8721 agree well with those for animal experimental morphological and functional endpoints for late effects in different organs and support the relevance of @entity8721 as a model for predicting late effects.

title: The predictive value of skin XXXX for late radiation effects in different normal tissues.

entities_list: @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectasia']

answer: @entity8721 :: (MESH:D013684,Disease) :: ['telangiectasia']


abstract: BACKGROUND: Symptoms are known to predict survival among @entity1 with @entity712 ( @entity712 ), but discrepancies exist between @entity1 ' and health providers' perceptions of @entity712 symptom burden. OBJECTIVE: The purpose of this study is to quantify the internal consistency, validity, and prognostic value of @entity1 perception of a broad range of @entity712 symptoms using an @entity712 -specific physical symptom measure, the 18-item @entity712 Somatic Perception Scale v. 3. METHODS: Factor analysis of the @entity712 Somatic Perception Scale was conducted in a convenience sample of 378 @entity1 with chronic @entity712 . Convergent validity was examined using the Physical Limitation subscale of the Kansas @entity296 Questionnaire. Divergent validity was examined using the Self-care of @entity712 Index self-care management score. One-year survival based on @entity712 Somatic Perception Scale scores was quantified using Cox regression controlling for Seattle @entity712 Model scores to account for clinical status, therapeutics, and lab values. RESULTS: The sample was 63% male, 85% white, 67% functionally compromised (New York Heart Association class III-IV) with a mean (SD) age of 63 (12.8) years. Internal consistency of the @entity712 Somatic Perception Scale was a = .90. Convergent (r = -0.54, P < .0001) and divergent (r = 0.18, P > .05) validities were supported. Controlling for Seattle @entity712 scores, @entity712 Somatic Perception Scale was a significant predictor of 1-year survival, with those most symptomatic having worse survival (hazard ratio, 1.012; 95% confidence interval, 1.001-1.024; P = .038). CONCLUSIONS: Perception of @entity712 symptom burden as measured by the @entity712 Somatic Perception Scale is a significant predictor of survival, contributing additional prognostic value over and above objective Seattle @entity712 Risk Model scores. This analysis suggests that assessment of a broad range of @entity712 symptoms, or those related to @entity1353 or early and subtle symptoms, may be useful in evaluating therapeutic outcomes and predicting event-free survival.

title: Psychometric Analysis of the Heart Failure Somatic Perception Scale as a Measure of XXXX Symptom Perception.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['City Cardiomyopathy']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: PURPOSE: Based largely on in vitro investigations and animal studies, investigators believe that disruptions of @entity2533 ( @entity2533 ) signaling contribute to the development and progression of @entity1 @entity14 . The purpose of this study was to directly assess the status of the @entity2533 signaling pathway in @entity14 and determine the effects of its disruption on clinical behavior and outcome. MATERIALS AND METHODS: Smad proteins are the principal intracellular components of the @entity2533 signaling pathway. We conducted a high-throughput analysis of the expression patterns of @entity2536 , phosphorylated (activated) @entity2536 (pSmad2), and @entity1594 in more than 600 @entity1 @entity14 specimens assembled in tissue microarrays. RESULTS: The vast majority (93.8%; 95% CI: 92%-96%) of @entity14 expressed phosphorylated @entity2536 , indicating the ability of the @entity5 to survive and proliferate within a microenvironment that contains bioactive @entity2533 . Twelve of 633 (1.9%; 95% CI: 1%-3%) cases failed to express @entity2536 , and 15 of 641 (2.3%; 95% CI: 1%-4%) cases failed to express @entity1594 . Moreover, 29 of 615 (4.7%; 95% CI: 3%-7%) of cases expressed @entity2536 but not its activated form (pSmad2), suggesting the presence of a @entity2533 receptor defect. Based on an analysis of 577 cases for which clinical outcome information was available, failure to express @entity2536 , pSmad2, or @entity1594 was associated with @entity5 , the presence of lymph node @entity3 , and a significantly shorter overall survival (median survival: 35 vs 58 months). DISCUSSION: Loss of Smad activation and/or expression occurs in approximately 10% of @entity14 . This subset has a poor prognosis because of its association with @entity1442 and the presence of lymph node @entity3 at diagnosis.

title: Loss of Smad signaling in @entity1 XXXX is associated with @entity1442 and poor prognosis.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'advanced-stage disease']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity2533 :: ('7040', 'Gene') :: ['TGF-beta', 'transforming growth factor-beta']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: A rapid light-induced decrease in @entity6708 is thought to play a role in regulating the permeability or light sensitivity of photoreceptor membranes. Photo-excited @entity8695 activates a @entity6370 -binding protein (G-protein) by catalyzing the exchange of bound @entity3006 for @entity3007 . This G-protein X @entity3007 complex activates the phosphodiesterase resulting in a decrease in @entity6708 concentration. We have observed two processes in vitro which may be relevant for the regulation of G-protein activation. First, we have found that free @entity3006 binds to G-protein with an affinity similar to that of @entity3007 . These two nucleotides appear to compete for a common site. Since G-protein X @entity3006 does not activate phosphodiesterase, light-induced changes in the @entity3007 / @entity3006 ratio known to occur on illumination may serve to reduce G-protein activation and hence reduce phosphodiesterase activation. Second, addition of @entity6708 in the presence of equimolar @entity3007 and @entity3006 causes @entity3007 binding to G-protein to be enhanced compared to @entity3006 binding. This effect increases as the @entity6708 concentration is increased from 0.05 to 2 mM. Thus, light-induced decreases in @entity6708 concentration may also act as a feedback control in reducing G-protein activation. One or both of these processes may be involved in the desensitization (light adaptation) of rod photoreceptors.

title: @entity6708 influences XXXX binding to frog photoreceptor G-protein.

entities_list: @entity6370 :: ('CHEBI:61292', 'Chemical') :: ['guanine nucleotide']

answer: @entity6370 :: (CHEBI:61292,Chemical) :: ['guanine nucleotide']


abstract: UNASSIGNED: Nanopipettes are an attractive single-molecule tool for identification and characterisation of nucleic acids and proteins in solutions. They enable label-free analysis and reveal individual molecular properties, which are generally masked by ensemble averaging. Having control over the pore dimensions is vital to ensure that the dimensions of the molecules being probed match those of the pore for optimization of the signal to noise. Although nanopipettes are simple and easy to fabricate, challenges exist, especially when compared to more conventional solid-state analogues. For example, a sub-20 nm pore diameter can be difficult to fabricate and the batch-to-batch reproducibility is often poor. To improve on this limitation, @entity655 ( @entity655 ) is used to deposit ultrathin layers of @entity5383 ( @entity16773 ) on the surface of the quartz nanopipettes enabling sub-nm tuning of the pore dimensions. Here, @entity16773 with a thickness of 8, 14 and 17 nm was deposited onto pipettes with a starting pore diameter of 75    5 nm whilst a second batch had 5 and 8 nm @entity16773 deposited with a starting pore diameter of 25    3 nm respectively. This highly conformal process coats both the inner and outer surfaces of pipettes and resulted in the fabrication of pore diameters as low as 7.5 nm. We show that @entity16773 modified pores do not interfere with the sensing ability of the nanopipettes and can be used for high signal-to-noise DNA detection. @entity655 provides a quick and efficient (batch processing) for fine-tuning nanopipettes for a broad range of applications including the detection of small biomolecules like RNA, aptamers and DNA-protein interactions at the single molecule level.

title: Fine tuning of nanopipettes using XXXX for single molecule sensing.

entities_list: @entity655 :: ('MESH:C535504', 'Disease') :: ['atomic layer deposition', 'ALD']

answer: @entity655 :: (MESH:C535504,Disease) :: ['atomic layer deposition']


abstract: BACKGROUND: British guidelines recommend treatment for mild @entity101 at a cardiovascular (CVD) risk threshold of 20% over 10 years. However, treatment is targeted at the equivalent coronary (CHD) risk of 15% over 10 years. We examined the relationship between CHD and CVD risk in @entity1 and @entity1 with mild @entity101 and assessed the accuracy of using a 10-year CHD risk threshold of 15% to identify @entity1 at a 10-year CVD risk > or = 20%. DESIGN: Cross-sectional survey of England in 1998. METHODS: We identified 5588 subjects aged 35-74 years free of @entity65 with complete data for risk assessment. Of these, 1364 (24.4%) had mild @entity101 (systolic pressure 140-159 mmHg or diastolic pressure 90-99 mmHg). The Framingham functions were used to estimate CHD and CVD event risk for each individual. RESULTS: At a 10-year CHD risk of 15%, the corresponding 10-year CVD risk for @entity1 and @entity1 , respectively was 20% and 21% in those aged < 55 years, and 24% and 25% in those aged > or = 55 years. Using a 10-year CHD risk threshold of 15% to identify @entity1 at a 10-year CVD risk > or = 20% had high specificity (>96%) in all four groups. For @entity1 and @entity1 respectively, the sensitivity was 73% (62-84%) and 62% (35-88%) in younger subjects, and 89% (85-93%) and 47% (38-56%) in older subjects. CONCLUSION: Using a 10-year CHD risk of 15% to target @entity1 at a 10-year CVD risk > or = 20% was reasonably accurate for @entity1 but missed about 50% of @entity1 eligible for antihypertensive treatment.

title: Coronary risk versus cardiovascular risk for treatment decisions in mild XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: A retrospective analysis of the University of Minnesota (Minneapolis) experience with @entity995 is presented. Seventy-five @entity1 were diagnosed with @entity995 between 1958 and 1983, of which 53 (71%) had at least one Reese-Ellsworth group V eye. Nineteen group V @entity1 and one group II @entity1 developed @entity66 recurrence. The cumulative actuarial rate of recurrence at 12 years was 36% for @entity1 with group V disease. The median time from diagnosis to recurrence for unilateral @entity1 was seven months and for bilateral @entity1 28 months (P = .001). @entity1 developing @entity66 had a 10-year actuarial survival rate postrecurrence of 34%. The four long-term survivors of extraocular recurrences had had isolated orbital or local soft tissue recurrences only. Features of group V @entity1 associated with extraocular recurrences were identified by univariate life table analyses. Clinical poor-risk factors included the nongenetic form of the disease (P = .03) and male sex (P = .02). Pathologic poor risk factors included rubeosis (P = .01), undifferentiated histology (P = .03), large @entity5 size (P = .05), and intraocular extension to the anterior segment (P = .02), retinal pigment epithelium (P = .03), choroid (P less than .001), and optic nerve beyond the lamina cribrosa (P = .02). Treatment-associated poor-risk factors included an optic nerve length of less than 5 mm removed at enucleation (P = .003). Multivariate life table analyses demonstrated the following parameters to be independent poor-prognostic factors: optic nerve length of less than 5 mm removed at enucleation (P = .001), optic nerve involvement (P = .004), and large @entity5 size (P = .01). These results will help to identify @entity1 with @entity995 who are at greatest risk for extraocular recurrence.

title: XXXX group V: an analysis of prognostic factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['extraocular disease']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma']

answer: @entity995 :: (MESH:D012175,Disease) :: ['Intraocular retinoblastoma']


abstract: BACKGROUND AND OBJECTIVES: @entity5834 is an active adulterant found in several drugs of abuse including coca paste (CP). We had previously demonstrated that @entity5834 potentiated the acute stimulant effect induced by CP seized samples. The role of @entity5834 in the expression of sensitization elicited by a CP seized sample (CP1) was here evaluated. METHODS: CP1 (equivalent dose of 10   mg/kg of @entity2072 ), @entity2072 (pure, 10   mg/kg), a combination of @entity2072 10   mg/kg plus @entity5834 2.5   mg/kg (CP1-surrogate) and saline (control) were intraperitoneally injected in male @entity35 under two different sensitization schedules. Ambulatory locomotion was recorded in 58 animals. RESULTS: After five daily CP1 injections and 5   days of withdrawal, CP1-challenged animals displayed a more robust sensitization than @entity2072 -treated animals. When a 3 injections-regime of CP1-surrogate or @entity2072 was assayed, only CP1-surrogate was able to elicit sensitization. DISCUSSION AND CONCLUSIONS: @entity5834 enhances and accelerates the CP1-induced sensitization. SCIENTIFIC SIGNIFICANCE: Results may shed light on the fast and high dependence observed in CP users. (Am J Addict 2015;XX:XX -XX).

title: XXXX enhances and accelerates the expression of sensitization induced by coca paste indicating its relevance as a main adulterant.

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['Caffeine', 'caffeine']

answer: @entity5834 :: (MESH:D002110,Chemical) :: ['Caffeine']


abstract: INTRODUCTION: State-based surveillance programs play a key role in @entity600 planning, prevention, education, support, and research activities. High-quality data are essential to all of these functions, and a key indicator of quality is timeliness. The Florida Birth Defects Registry (FBDR)-one of the largest population-based state registries in the United States-faces challenges with timeliness, as evidenced by its 18-month lag time. The goal of this study was to determine if the timeliness of the FBDR could be improved without significantly reducing the @entity1939 of @entity600 ascertainment. METHODS: Using 2006-2011 data from the FBDR, we first investigated the timing of diagnosis of @entity600 by estimating the effect of different periods of follow-up on prevalence rates reported by the FBDR. We achieved this through retrospective reconstructions of the FBDR under 5 different scenarios with progressively narrower follow-up windows for each @entity1 , and by comparing recalculated rates to the rate of the current FBDR with 1 year of follow-up. We then considered scenarios in which the time lag used to construct the FBDR was reduced (15, 12, 9, and 6 months) by using less data (from 7 to 4 quarters). Recalculated rates were again compared to the current FBDR constructed with 2 years of data and an 18-month lag. Analyses were performed overall and for 44 specific defects. RESULTS: During the 6-year study period, the FBDR identified more than 27,000 @entity1 with a defect detected during the first year of life. Restricting follow-up from 1 year to 9 months would only result in a loss of 1.4% of cases. Cutting follow-up in half to 6 months would miss 3.2% of cases, although there was significant variation across defects. Improving timeliness had a small impact on @entity1939 of ascertainment. Overall, compiling the FBDR with only 6 quarters of Florida Agency for Health Care Administration data (as opposed to 8 quarters) would improve timeliness by approximately 6 months, resulting in a registry that is 99.4% complete. DISCUSSION: Six-to-nine month improvements in timeliness were achievable with a minimal sacrifice in @entity1939 (0.6%-1.7%). Efforts to enhance data quality through the assessment of timeliness and @entity1939 indicators are not unique to @entity600 surveillance programs. Other programs, particularly those with similar passive case ascertainment protocols, can use our findings to consider a more timely release of registry data, or to design similar investigations of their own.

title: Evaluating Difficult Decisions in Public Health Surveillance: Striking the Right Balance between Timeliness and XXXX .

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['completeness']

entities_list: @entity1 :: ('9606', 'Species') :: ['infants', 'infant']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['birth defect', 'birth defects']

answer: @entity1939 :: (MESH:D001766,Disease) :: ['Completeness']


abstract: We present 3 @entity1 with @entity8817 ( @entity8817 ) and severe central nervous system (CNS) complications. All @entity1 had at least 4 positive criteria of Bohan and Peter, which confirmed a definite diagnosis of @entity8817 . They were all male, and had a relatively high @entity1011 kinase value at admission (1532-4260 U/l). Besides, progressive proximal @entity425 and @entity1910 , one @entity1 presented with rapid irreversible @entity227 . Ophthalmologic examination showed active @entity1333 . After 2 weeks of treatment with immunosuppressive drugs and being in improved, relatively stable clinical condition, all 3 @entity1 developed generalized @entity3173 . Other causes of the neurological symptoms could be excluded. In all 3 @entity1 , the course of @entity8817 was fatal. The clinical symptoms and further investigations in our @entity1 show CNS involvement in @entity8817 . Although rarely reported, CNS @entity455 can be a serious and life-threatening complication of @entity8817 .

title: Case report: severe central nervous system involvement in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['decline of vision']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vasculopathy']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis of the retina']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['muscle weakness']

entities_list: @entity3173 :: ('MESH:D004830', 'Disease') :: ['tonic-clonic convulsions']

entities_list: @entity8817 :: ('MESH:C538250', 'Disease') :: ['juvenile dermatomyositis', 'JDM']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity8817 :: (MESH:C538250,Disease) :: ['juvenile dermatomyositis']


abstract: Calsequestrin is a moderate-affinity, high-capacity @entity141 binding protein in the sarcoplasmic reticulum of skeletal and cardiac muscle that seems to act as an intralumenal @entity141 buffer. Two different isoforms have been described in mammals, the skeletal and cardiac isoforms, encoded by CASQ1 and CASQ2 genes, respectively. In this study, we present molecular phylogenetic evidence of a gene duplication event of both calsequestrin genes in teleosts, referred to as casq1a/casq1b and casq2a/casq2b. We obtained the entire cDNAs encoding the four genes in the @entity16988 ( @entity16988 Kaup). Main features and sequence identities with other fish and @entity1 calsequestrins are described. Expression profiles during larval development and in juvenile tissues were analyzed using a real-time PCR approach. In juvenile fish, casq1a and casq1b were highly expressed in skeletal muscle, whereas the highest casq2a and casq2b transcript levels were detected in heart and brain, respectively. During metamorphosis, casq2a and casq1b expression remained unchanged. In contrast, casq1a and casq2b mRNAs exhibited a continuous increase from the beginning of metamorphosis until post-metamorphosis. Transcriptional regulation of casq1 and casq2 genes by thyroid hormones (THs) was also evaluated. Larvae exposed to the goitrogen @entity8542 (TU) exhibited higher casq1a mRNA levels than untreated control, whereas expression of the remaining genes did not vary significantly. Moreover, addition of exogenous T4 hormone to TU-treated larvae increased the casq1a steady-state levels with respect to the untreated control at metamorphosis climax. Comprehensively, these results demonstrate the existence of four calsequestrin genes in teleosts differentially regulated by THs.

title: Duplication of calsequestrin genes in teleosts: molecular characterization in the @entity16988 ( XXXX ).

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity16988 :: ('28829', 'Species') :: ['Senegalese sole', 'Solea senegalensis']

entities_list: @entity8542 :: ('MESH:D013890', 'Chemical') :: ['thiourea']

answer: @entity16988 :: (28829,Species) :: ['Solea senegalensis']


abstract: PURPOSE: This study was designed to determine whether vonapanitase (formerly PRT-201), a recombinant @entity1 elastase, treatment can fragment the protein @entity2362 in elastic fibers and cause dilation of @entity731 @entity1 peripheral arteries subjected to ex vivo balloon angioplasty. MATERIALS AND METHODS: Seven @entity1 undergoing lower limb amputation for @entity3657 or who died and donated their bodies to science donated 11 tibial arteries (5 anterior, 6 posterior) for this study. All arteries were @entity731 by visual inspection. The arteries underwent ex vivo balloon angioplasty and thereafter were cut into rings and studied on wire myographs where the rings were stretched and @entity2701 was recorded. After treatment with vonapanitase 2 mg/mL or vehicle control, myography was repeated and the rings were then subject to @entity2362 content measurement using a @entity13403 radioimmunoassay and elastic fiber visualization by histology. The wire myography data were used to derive compliance, stress-strain, and incremental elastic modulus curves. RESULTS: Vonapanitase treatment reduced @entity2362 ( @entity13403 ) content by 60% and decreased elastic fiber histologic staining. Vonapanitase-treated rings experienced less @entity2701 at any level of stretch and as a result had shifts in the compliance and stress-strain curves relative to vehicle-treated rings. Vonapanitase treatment did not alter the incremental elastic modulus curve. CONCLUSIONS: Vonapanitase treatment of @entity731 @entity1 peripheral arteries after ex vivo balloon angioplasty fragmented @entity2362 in elastic fibers, decreased @entity2701 in the rings at any level of stretch, and altered the compliance and stress-strain curves in a manner predicting @entity384 in vivo. Based on this result, local treatment of balloon angioplasty sites may increase blood vessel diameter and thereby improve the success of balloon angioplasty in @entity3657 .

title: Recombinant XXXX Elastase Alters the Compliance of Atherosclerotic Tibial Arteries After Ex Vivo Angioplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease']

entities_list: @entity13403 :: ('MESH:D003895', 'Chemical') :: ['desmosine']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['arterial dilation']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic']

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: A mutagenesis approach was initiated in order to examine further the folding behavior of the alpha-subunit of the @entity526 @entity2340 synthase. A random single base pair saturation mutagenesis procedure (Myers, R.M., Lerman, L.S., and Maniatis, T. (1985) Science 229, 242-247) was applied in vitro to subcloned fragments of the trpA gene, which codes for this polypeptide. Mutagenesis plasmid vectors were constructed containing three fragments of the trpA gene which together code for about half of the total @entity535 residues of the alpha-subunit. The vectors were constructed such that each strand of each trpA fragment could be altered. These trpA fragments were mutagenized in vitro (using @entity17241 , @entity5189 , @entity7783 , and @entity19592 ), and several thousands of mutants have been isolated. Thirty-two mutants, contained within the first two trpA fragments (which encompass the first 206 base pairs of the trpA gene and encode the first 63 residues of the alpha-subunit) have been sequenced. Of these, 20 (63%) contained single base pair alterations, 12 (37%) contained multiple alterations, and 17 (53%) of these base pair alterations resulted in single @entity535 substitutions. Selected mutant trpA fragments were subcloned into an overexpression vector in which the trpA gene is controlled by the tac promoter and is inducible by @entity1132 . The kinetics and extent of induction show that after 22 h of induction, the wild-type alpha-subunit constituted about 30% of the total protein. A simple one-step purification procedure for the alpha-subunit is described in which 15 mg of alpha-subunit can be obtained from 200 ml of fully induced cultures. The mutant trpA genes were induced for mutant alpha-subunit expression, and an initial examination of their properties in crude extracts was performed. Of the 17 mutant proteins examined, most were overproduced to levels comparable to that for the wild-type alpha-subunit. An analysis of the apparent stability, beta 2-subunit-activating activity, and intrinsic activity of this group of mutant alpha-subunits suggests that many @entity535 alterations have no apparent effect; there is a variety of novel functional defects; and a sequence located near residues 28 through 54 may be particularly critical for the normal folding of the polypeptide.

title: In vitro mutagenesis and overexpression of the XXXX trpA gene and the partial characterization of the resultant @entity2340 synthase mutant alpha-subunits.

entities_list: @entity19592 :: ('MESH:D011196', 'Chemical') :: ['potassium permanganate']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan']

entities_list: @entity17241 :: ('MESH:D009608', 'Chemical') :: ['nitrous acid']

entities_list: @entity7783 :: ('MESH:C029424', 'Chemical') :: ['hydrazine']

entities_list: @entity5189 :: ('MESH:C030544', 'Chemical') :: ['formic acid']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']


abstract: PURPOSE: To retrospectively assess the local control and intermediate- and long-term survival of @entity1 with liver metastases from @entity0 who have undergone percutaneous ultrasonography (US)-guided radiofrequency (RF) ablation. MATERIALS AND METHODS: This study was approved by the hospital ethics committee, and all @entity1 provided written informed consent. RF ablation was used to treat 87 @entity0 (mean diameter, 2.5 cm) in 52 female @entity1 (median age, 55 years). Inclusion criteria were as follows: fewer than @entity5 , maximum @entity5 diameter of 5 cm or smaller, and disease either confined to the liver or stable with medical therapy. Forty-five (90%) of 50 @entity1 had previously undergone chemotherapy, hormonal therapy, or both, and had no response or an incomplete response to the treatment. Contrast material-enhanced computed tomography and US were performed to evaluate complications and technical success and to assess for local @entity5 progression during follow-up. The Kaplan-Meier method was used to assess survival, and results were compared between groups with a log-rank test. Cox regression analysis was used to assess independent prognostic factors that affected survival. RESULTS: Complete @entity5 @entity39 was achieved in 97% of @entity5 . Two (4%) minor complications occurred. Median time to follow-up from diagnosis of liver @entity3 and from RF ablation was 37.2 and 19.1 months, respectively. Local @entity5 progression occurred in 25% of @entity1 . New intrahepatic metastases developed in 53% of @entity1 . From the time of first RF ablation, overall median survival time and 5-year survival rate were 29.9 months and 27%, respectively. From the time the first liver @entity3 was diagnosed, overall median survival time was 42 months, and the 5-year survival rate was 32%. @entity1 with @entity5 2.5 cm in diameter or larger had a worse prognosis (hazard ratio, 2.1) than did @entity1 with @entity5 smaller than 2.5 cm in diameter. CONCLUSION: Survival rates in selected @entity1 with @entity0 treated with RF ablation are comparable to those reported in the literature that were achieved with surgery or laser ablation.

title: XXXX : US-guided percutaneous radiofrequency ablation--intermediate and long-term survival rates.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer liver metastases', 'breast cancer']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'five tumors', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast cancer liver metastases']


abstract: BACKGROUND/AIMS: Approximately 20% of @entity1 undergoing surgery for @entity31 will retain their rectum. A single-stage proctocolectomy could be an appropriate procedure in @entity1 who are definitely not candidates for a later restorative procedure, but it is generally not advised in acutely ill @entity1 . The aim was to investigate the safety of one-stage proctocolectomy under elective and non-elective circumstances, with specific reference to identifying possible risk factors for @entity260 . METHODS: A retrospective cohort study, including 54 consecutive @entity1 undergoing proctocolectomy for @entity31 . Out of these, 27 (50%) were admitted non-electively. RESULTS: @entity260 were observed in 30 @entity1 (54%). @entity6783 , wound @entity281 , and @entity73 healing were observed in 10 (18.5%), 8 (14.8%), and 10 (18.5%) of the @entity1 , respectively. There was no difference between elective and non-elective cases. Complications were observed more often in @entity1 receiving high-dose corticosteroids (18/26 vs. 12/28; p = 0.06). Impaired perineal wound healing and reoperations were observed more often in the corticosteroid-treated group (8/26 vs. 2/28; p = 0.04 and 12/26 vs. 1/28; p = 0.0003). CONCLUSIONS: Proctocolectomy is equally safe under elective and non-elective situations, but a preoperative treatment with high-dose corticosteroids is associated with an increased risk of complications and reoperations.    2015 S. Karger AG, Basel.

title: Safety of Proctocolectomy for XXXX Under Elective and Non-Elective Circumstances: Preoperative Corticosteroid Treatment Worsens Outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired perineal wound']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Postoperative complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity6783 :: ('MESH:D013529', 'Disease') :: ['Wound dehiscence']

answer: @entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']


abstract: INTRODUCTION: The impact of duration of T1DM on outcomes following simultaneous @entity8 (PTA) is currently unknown. MATERIALS AND METHODS: A total of 451 pancreas transplants performed at a single institution between January 2003 and April 2013 (SPK n = 238, PAK, n = 97, and PTA, n = 116) were divided into three groups based on cumulative years of T1DM (0-20 years, 21-30 years, and >30 years). Early (7-day) and late (90-day) pancreas allograft loss, @entity1 and pancreas allograft survivals were analyzed. RESULTS: While, PAK was more common in recipients with >30 years of T1DM (29%, p < 0.0047), PTA was more common in recipients with 0-20 years of T1DM (41%, p < 0.0011). In all transplant types, recipients age was significantly higher the longer the duration of @entity6 . Although longer duration of T1DM correlated with a higher rate of major amputations in PAK recipients (p < 0.0032), no difference was observed in SPK or PTA. While early pancreas graft loss was 2-4% in SPK and PAK with shorter or longer T1DM (p = n.s.), it reached to 10% in PTA with T1DM > 30 years (p < 0.0097). Longer duration of T1DM affected late pancreas graft loss in PAK @entity1 (8%, p < 0.0349). @entity1 and death-censored graft survival rates were similar in all types of pancreas transplantation extracted by accumulation of years of T1DM prior to transplant. CONCLUSIONS: Longstanding T1DM does not seem to negatively impact recipient outcomes following all types of pancreas transplantation.

title: Impact of duration of XXXX on outcome following pancreas transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['pancreas and kidney transplantation (SPK), pancreas after kidney transplantation (PAK), and pancreas transplantation alone']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: PURPOSE: @entity1419 usually presents late in the clinical course and has a poor prognosis. No effective systemic therapy is currently available. This study aimed to determine the efficacy and @entity137 of the ECF regimen ( @entity1259 , @entity900 . and 24-h continuous infusion of @entity1487 ) in advanced @entity1419 . @entity1 AND METHOD: On day 1, @entity1259 50 mg/m(2) and @entity900 60 mg/m(2) were administered i.v., repeated every 21 days. @entity1487 (200 mg/m(2)/day was given continuous i.v. via an ambulatory infusion pump throughout the treatment course. A total of 24 @entity1 (15 @entity1 and nine @entity1 ) with advanced @entity1419 between August 1996 and April 2002 were enrolled in this study. RESULTS: Of the 20 evaluable @entity1 , two had partial response (10%) and nine had stable disease (45%), including two minor response. Grade 3/4 @entity1398 was observed in six @entity1 , while grade 3/4 @entity882 was seen in five @entity1 . There was no @entity281 or @entity548 during any of the cycles of chemotherapy. CONCLUSION: ECF regimen is well-tolerated but is not an effective treatment for advanced @entity1419 . Newer clinical trials with combination drugs should be developed.

title: @entity1259 , @entity900 , and protracted infusion of XXXX (ECF) in advanced @entity1419 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['thrombocytopenic bleeding']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['neutropenic infection']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1419 :: ('MESH:C535533', 'Disease') :: ['Intrahepatic cholangiocarcinoma', 'intrahepatic cholangiocarcinoma']

answer: @entity1487 :: (MESH:D005472,Chemical) :: ['5-FU']


abstract: BACKGROUND:: The relationships between physical activity, cognition, and development of @entity179 represent an area of intense research interest. Meta-analyses and prospective cohort studies show that greater levels of physical activity are associated with lower @entity303 risk. Most studies, however, depend on self-report data that are subject to recall and other biases. Obtaining objective and quantitative physical activity data could strengthen observational study validity. OBJECTIVE:: To examine the association between objectively measured daytime activity and @entity73 ( @entity73 ) or @entity195 ( @entity195 ). METHODS:: The objective was addressed through the development of a structured, critically appraised topic. We incorporated a clinical scenario, background information, a structured question, literature search strategy, critical appraisal, results, evidence summary, commentary, and bottom line conclusions. @entity1 included consultant and resident neurologists, clinical epidemiologists, a medical librarian, and behavioral neurology and neuropsychiatry content experts. RESULTS:: We selected a prospective, single-center cohort study of 716 cognitively normal elderly @entity1 followed for 3.5 years. Greater levels of physical activity, as measured using wrist actigraphy, were associated with a lower risk of incident @entity73 or @entity195 (hazard ratio, 0.477; 95% confidence interval, 0.273-0.832). CONCLUSIONS:: Objective measurement confirms that greater levels of physical activity are associated with decreased risk of a future diagnosis of @entity73 or @entity195 . Further studies are needed to confirm the temporal association of exercise and future cognitive health and understand the relevant underlying biological mechanisms.

title: Physical Activity Level and Future Risk of Mild @entity73 or XXXX : A Critically Appraised Topic.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease']

answer: @entity303 :: (MESH:D003704,Disease) :: ['Dementia']


abstract: OBJECTIVE: Spasticity is a common complication with @entity16 and @entity75 . Instrumented systems to evaluate @entity508 often cannot provide an immediate result, thus limiting their clinical usefulness. In this study we investigated the accuracy and reliability of the portable Neurokinetics @entity35125 Ridgidity Analyzer to measure @entity2693 of the ankle joint in 46 controls, 14 spinal cord injured (SCI) and 23 @entity15 ( @entity15 ) @entity1 . METHODS: Ankle @entity2693 measures were made twice by two raters, at speeds above and below the expected stretch reflex threshold. Ankle torque was measured with the portable device and a stationary torque motor. Inter- and intra-rater reliability was assessed with the intra-class correlation coefficient (ICC). RESULTS: Stiffness measures with the portable and stationary devices were significantly correlated for controls and @entity15 @entity1 (p < 0.01). Intra-rater reliability for the portable device ranged from 0.60-0.89 (SCI) and 0.63-0.67 (control) and inter-rater reliability ranged from 0.70-0.73 (SCI) and 0.61-0.77 (control). Ankle @entity2693 measures in SCI and @entity15 @entity1 were significantly larger than in controls for both slow (p < 0.05) and fast movements (p < 0.01), with @entity2693 being larger for fast compared to slow movements in SCI and @entity15 @entity1 (p < 0.05), but not in controls (p = 0.5). CONCLUSION: The portable device correlated well with measures obtained by a torque motor in both controls and @entity15 @entity1 , showed high intra- and inter-rater reliability for the SCI @entity1 , and could easily distinguish between stiff and control ankle joints. However, the device, in its current form, may be less accurate during rapid movements when inertia contributes to @entity2693 and the shape of the air-filled pads did not provide a good interface with the foot. SIGNIFICANCE: This study demonstrates that a portable device can potentially be a useful diagnostic tool to obtain reliable information of @entity2693 for the ankle joint.

title: Assessment of a portable device for the quantitative measurement of ankle joint @entity2693 in XXXX individuals.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['CNS lesions']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases']

entities_list: @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']

answer: @entity508 :: (MESH:D009128,Disease) :: ['spastic']


abstract: BACKGROUND AND OBJECTIVE: @entity6675 is a @entity154 with increasing incidence, easy prenatal diagnosis and extremely variable postnatal outcomes. Our objective was to systematically review the evidence regarding the association between prenatal ultrasound signs (intraabdominal bowel dilatation [IABD], extraabdominal bowel dilatation, @entity6676 [ @entity6676 ], bowel wall thickness, @entity2978 , and small for gestational age) and perinatal outcomes in @entity6675 (bowel @entity1146 , intra uterine @entity204 , @entity204 , time to full enteral feeding, length of total parenteral nutrition and length of in hospital stay). METHODS: Medline, Embase, and Cochrane databases were searched electronically. Studies exploring the association between antenatal ultrasound signs and outcomes in @entity6675 were considered suitable for inclusion. Two reviewers independently extracted relevant data regarding study characteristics and pregnancy outcome. All meta-analyses were computed using individual data random-effect logistic regression, with single study as the cluster unit. RESULTS: Twenty-six studies, including 2023 fetuses, were included. We found significant positive associations between IABD and bowel @entity1146 (odds ratio [OR]: 5.48, 95% confidence interval [CI] 3.1-9.8), @entity2978 and bowel @entity1146 (OR: 3.76, 95% CI 1.7-8.3), and @entity6676 (OR: 5.58, 95% CI 1.3-24.1). No other ultrasound sign was significantly related to any other outcome. CONCLUSIONS: IABD, @entity2978 , and @entity6676 can be used to an extent to identify a subgroup of neonates with a prenatal diagnosis of @entity6675 at higher risk to develop postnatal complications. Data are still inconclusive on the predictive ability of several signs combined, and large prospective studies are needed to improve the quality of prenatal counseling and the neonatal care for this condition.

title: Prenatal Risk Factors and Outcomes in XXXX : A Meta-Analysis.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomaly']

entities_list: @entity2978 :: ('MESH:D006831', 'Disease') :: ['polyhydramnios']

entities_list: @entity6675 :: ('MESH:D020139', 'Disease') :: ['Gastroschisis', 'gastroschisis']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['neonatal death', 'death']

entities_list: @entity6676 :: ('MESH:D013271', 'Disease') :: ['gastric dilatation', 'GD', 'GD and neonatal death']

answer: @entity6675 :: (MESH:D020139,Disease) :: ['Gastroschisis']


abstract: beta-Lactoglobulins from pooled milk ( @entity12526 ) are isolated and characterized. The complete primary structure of the major @entity2483 is presented. The @entity535 sequence was elucidated by automated Edman degradation of tryptic peptides and @entity13518 cleavage products in a liquid phase sequencer. The tryptic and cyanogen @entity4001 peptides were separated by reverse-phase ( @entity71930 ) or size exclusion (TSK 2000 SW) high performance liquid chromatography. @entity1707 beta-lactoglobulin is composed of only 159 @entity1522 in contrast to other beta-lactoglobulins which contain 162 or 166 @entity1522 . Sequence alignment with previously sequenced beta-lactoglobulins was obtained by introducing two gaps at positions 115 and 151-152. Thus @entity291 beta-lactoglobulin A reveals 62 @entity535 substitutions. The phylogenetic distance from @entity1641 @entity71931 is indicated by 49.4% and 62% @entity535 exchanges, respectively. @entity1707 beta-lactoglobulin is a mixture of two chains with @entity7647 or Thr at position 119. The free @entity1432 group is localized at position 59. The structural and functional aspects of beta-lactoglobulins and its role in @entity904 ( @entity904 ) transport are discussed.

title: @entity1707 beta-lactoglobulin I ( XXXX , Artiodactyla). The primary structure of the major component.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity12526 :: ('9825', 'Species') :: ['Sus scrofa domestica']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino-acid']

entities_list: @entity13518 :: ('MESH:D003488', 'Chemical') :: ['cyanogen bromide']

entities_list: @entity904 :: ('MESH:D014801', 'Chemical') :: ['vitamin A', 'retinol']

entities_list: @entity2483 :: ('MESH:C566443', 'Disease') :: ['beta-lactoglobulin component I']

entities_list: @entity4001 :: ('CHEBI:15858', 'Chemical') :: ['bromide']

answer: @entity12526 :: (9825,Species) :: ['Sus scrofa domestica']


abstract: @entity3981 ( @entity3981 ) of the @entity788 is a rare @entity5 with an extremely low incidence rate. While the number of reported @entity1 with @entity3981 is relatively small, a long-term survival rate has been noted in @entity1 with neuroendocrine differentiation. A 39-year-old @entity1 visited our emergency department for @entity360 . Endoscopy indicated extrinsic compression of the posterior body of the stomach, together with a large, 10-cm, central @entity1066 covered with @entity39 tissue. Abdominal computed tomography (CT) indicated a lesion that involved the whole of the @entity788 , with a @entity292 in the stomach, which was suspected of being a @entity5 of the @entity788 . Magnetic resonance imaging (MRI) of the @entity788 was performed, and the results further strengthened our suspicions by demonstrating the presence of @entity5409 and @entity5 buds. A total duodenopancreatectomy, including total splenectomy and gastrectomy, was performed, along with two independent Roux-en-Y anastomoses (one esojejunal and one hepaticojejunal). The @entity5 also had a wide opening in the stomach. The @entity1 's postoperative course was marked by partial @entity715 of the portal vein, which was treated medically. Histopathological examination provided evidence of pancreatic @entity3981 . The diagnosis of @entity3981 should be considered in the presence of cutaneous lesions, which were absent in the case of our @entity1 , and colonoscopy is also highly desirable because of the various forms associated with @entity1412 . The prognosis, which includes a 5-year survival rate of 45%, in the population with an R0 resection is better than that for ductular @entity420 , thus prompting the more aggressive management of this type of @entity5 .

title: @entity3981 : a rare XXXX with a particular clinical and paraclinical presentation.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreas']

entities_list: @entity5409 :: ('MESH:D052177', 'Disease') :: ['cystic lesions']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'degenerative intraductal papillary mucinous tumor']

entities_list: @entity3981 :: ('MESH:D018267', 'Disease') :: ['ACC', 'Acinar cell carcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['upper gastrointestinal bleeding']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: OBJECTIVE: When significant coronary lesions are identified by angiography, regional left ventricular (LV) contractile function often plays a role in determining candidacy for revascularization. To improve on current subjective and nonquantitative metrics of regional LV function, we tested a z-score "normalization" of regional strain information quantified from clinically acquired high-resolution LV geometric datasets. METHODS: Test subjects (n  =  120) underwent cardiac MRI with multiple 3-dimensional strain parameters calculated from tissue tag-plane displacement data. Sixty healthy volunteers contributed strain parameter data at each of 15,300 LV grid points, to form a normal @entity1 database. Point-specific database comparisons were made in 60 @entity1 who had documented @entity453 ( @entity453 ), by angiography. @entity1 -specific, color-coded 3-dimensional LV maps of z-score-normalized contractile function were generated. RESULTS: Blinded clinical review indicated that 55% (33 of 60) of the @entity1 with @entity453 had significant regional contractile abnormalities by 1 of 3 "gold-standard" criteria: (1) Q waves on electrocardiography (ECG); (2) @entity1188 on radionuclide single-photon emission computed tomography (SPECT); or (3) @entity910 or @entity910 on echocardiography. Consistency among all gold-standard metrics was found for only 19% (6 of 31) of @entity1 with @entity453 who had >= 2 available metrics. Blinded MRI-based, multiparametric, strain z-score localization of contractile abnormalities was accurate in 89% (ECG), 97% (SPECT), and 95% (echocardiography). CONCLUSIONS: Nonsubjective normalization of regional LV contractile function by z-score calculation from a normal @entity1 database can localize and quantitatively display regional wall motion abnormalities in @entity1 with @entity453 . This high-resolution localization of regional wall motion abnormalities may help improve the accuracy of therapeutic intervention in @entity1 who have @entity453 .

title: Quantifying "normalized" regional left ventricular contractile function in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human strain', 'patients', 'Patient']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary  artery disease']

entities_list: @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesia', 'akinesia']

answer: @entity453 :: (MESH:D003324,Disease) :: ['ischemic coronary artery disease']


abstract: BACKGROUND: Hepatic metastases from @entity14 frequently recur after resection and hepatic micrometastases most likely are important in the development of such recurrences. The objectives of the current study were to assess the feasibility of the immunohistochemical detection of hepatic micrometastases from @entity14 and to determine their clinical significance. METHODS: Fifty-three @entity1 underwent curative hepatic resection for @entity14 metastases. Multiple tissue sections were cut from the advancing margin of the largest hepatic @entity3 in each @entity1 and were stained with an antibody against @entity2225 to detect hepatic micrometastases, which were defined as discrete microscopic @entity5 surrounding the dominant @entity3 . RESULTS: Normal hepatocytes and intrahepatic bile duct epithelia stained negative for @entity2225 in all @entity1 , whereas the largest @entity99 stained positive in 46 @entity1 (86.8%). Among the 46 @entity1 with @entity99 that were positive for @entity2225 , hepatic micrometastases were found immunohistochemically in 32 @entity1 (69.6%). The presence of hepatic micrometastases was associated with a larger number of macroscopic hepatic metastases (P = 0.047) and @entity1 with hepatic micrometastases were found to demonstrate a higher probability of intrahepatic recurrence (P = 0.003) compared with those @entity1 without hepatic micrometastases. In addition, @entity1 with hepatic micrometastases demonstrated a worse survival (10-year survival rate of 21.9%) compared with those @entity1 without hepatic micrometastases (10-year survival rate of 64.3%) (P = 0.017). CONCLUSIONS: Immunohistochemical detection of hepatic micrometastases is feasible in @entity1 with @entity14 . Hepatic micrometastasis indicates widespread hepatic involvement and thus predicts an increased risk of intrahepatic recurrence after hepatic resection and a poorer @entity1 prognosis.

title: Immunohistochemically detected hepatic micrometastases predict a high risk of intrahepatic recurrence after resection of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancerous lesions']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma liver metastases', 'colorectal carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumors']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma liver metastases']


abstract: INTRODUCTION: Laparoscopic (LAP) colectomy is now the "gold" standard for @entity4436 ; the role of @entity8566 ( @entity8566 ) and Open methods today is unclear. This study assessed the elective use of these methods for @entity4436 . METHODS: A retrospective review of demographic, comorbidity (Carlson Comorbidity Index [CCI]), resection type, and short-term outcomes was carried out. RESULTS: There were 125 (44.5%) LAP, 125 (44.5%) @entity8566 , and 31 (11%) Open cases (overall N = 281). The mean age, body mass index, and percentage of high-risk @entity1 (CCI score >2) of the @entity8566 group were greater (P < .05) than the LAP group (vs Open, P = ns). The Open group's mean age and percent with CCI >2 was greater when compared with the LAP group (P < .05). More Open (P < .05) and @entity8566 @entity1 had complex disease (Open, 63%; @entity8566 , 40%, LAP, 22%) and were diverted (Open, 35%; @entity8566 , 10%; LAP, 3%). Time to bowel movement was not different; however, there was a stepwise increase in median length of stay (LOS; days) from the LAP (5 days) to @entity8566 (6 days) to Open group (7 days) (P < .05 for all). The LAP complication rate (22.4%) was lower (P < .05) than the @entity8566 (42.4%) or Open groups' (45.2%) rates. The LAP surgical site infection rate (5.6%) was lower (P < .05) than the @entity8566 (12.8%) or Open groups (19.6%). CONCLUSION: The @entity8566 and Open groups had more high risk, complex disease, diverted, and older @entity1 than the LAP group; likewise, the overall complication rate and LOS was higher in the @entity8566 and Open groups. Use of @entity8566 methods likely contributed to the high minimally invasive surgery utilization rate (89%).

title: Surgical Treatment of XXXX : Hand-Assisted Laparoscopic Resection Is Predominantly Used for Complex Cases and Is Associated With Increased Postoperative Complications and Prolonged Hospitalization.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8566 :: ('MESH:D060831', 'Disease') :: ['HAL', 'hand-assisted LAP']

entities_list: @entity4436 :: ('MESH:D004238', 'Disease') :: ['diverticulitis']

answer: @entity4436 :: (MESH:D004238,Disease) :: ['Diverticulitis']


abstract: PURPOSE OF THE STUDY: To facilitate replication, we examined delivery characteristics, acceptability, and @entity308 outcomes of a home-based intervention, Get Busy Get Better, Helping Older Adults Beat the Blues (GBGB). GBGB, previously tested in a randomized trial, reduced @entity308 symptoms and enhanced quality of life in African Americans. DESIGN AND METHODS: A total of 208 African Americans aged above 55 years with @entity1 Health Questionnaire (PHQ-9) scores >= 5 on two subsequent screenings were randomized to receive GBGB immediately or 4 months later. GBGB involves up to 10 home sessions consisting of care management, referral/linkage, @entity308 education/symptom recognition, stress reduction, and behavioral activation. Interventionists recorded delivery characteristics (dose, intensity) and perceived acceptability of sessions. Baseline and post-tests were used to characterize @entity1 and examine associations between dose/intensity and @entity308 scores. @entity1 satisfaction and perceived benefits were examined at 8 months. RESULTS: Of 208 @entity1 , 181 (87%, mean age = 69.6) had treatment data. Of these, 165 (91.2%) had >= 3 treatment sessions (minimal dose). @entity1 had on average 8.1 sessions (SD = 2.6) for an average of 65.4min (SD = 18.3) each. Behavioral activation and care management were provided the most (average of six sessions for average duration = 17.9 and 22.2min per session respectively), although all @entity1 received each treatment component. GBGB was perceived as highly acceptable and beneficial by interventionists and @entity1 . More sessions and time in program were associated with greater symptom reduction. IMPLICATIONS: GBGB treatment components were highly acceptable to @entity1 . Future implementation and sustainability challenges include staffing, training requirements, reimbursement limitations, competing agency programmatic priorities, and generalizability to other groups.

title: Delivery Characteristics, Acceptability, and @entity308 Outcomes of a Home-based XXXX Intervention for Older African Americans: The Get Busy Get Better Program.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participant', 'Patient', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: OBJECTIVE: To report the use of umbilical cord blood (UCB) stem cell transplantation in @entity17454 ( @entity17454 ) when a matched sibling donor was unavailable. METHODS: Three @entity1 with @entity17454 received unrelated umbilical cord blood stem cell transplantation after a preparative regimen for the treatment of @entity1200 . The @entity1 ranged in age from 1.9 to 7.9 years. The cord blood units were 4/6 HLA antigen matches in 2 @entity1 and 5/6 in 1 @entity1 , with molecular HLA-DR match in all 3 @entity1 . RESULTS: The time for neutrophil engraftment (ANC >500/mm(3)) was 11 to 16 days, and the average time for platelet engraftment was 36 to 49 days. One @entity1 had no evidence of GvHD, 1 @entity1 grade I, and 1 @entity1 grade II. No @entity1 had chronic GvHD. The @entity1 with grade II GvHD also had gut involvement. Immunologic reconstitution demonstrated that cord blood stem cell transplantation resulted in consistent and stable T-, B-, and NK-cell development. Functional B-cell antibody responses revealed that 2 of the @entity1 in whom IVIG has been discontinued had low detectable antibody responses to @entity116 and diphtheria toxoid immunizations at 18 to 24 months after transplantation. CONCLUSIONS: Unrelated umbilical donor cord blood is an alternative source of stem cells for transplantation in @entity1 with @entity17454 when a suitable HLA-matched donor is not available. Benefits of UCB include rapid and reliable recovery of immune function, low risk of GvHD, and low viral transmission rate.

title: Umbilical cord blood transplantation in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'child']

entities_list: @entity17454 :: ('MESH:D014923', 'Disease') :: ['Wiskott Aldrich syndrome', 'WAS']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['combined immunodeficiency diseases']

answer: @entity17454 :: (MESH:D014923,Disease) :: ['Wiskott Aldrich syndrome']


abstract: PURPOSEThe administration of a single-course antenatal @entity228 treatment is recommended for pregnant @entity1 between 24 and 34 weeks with risk of @entity600 . The maximum effect is achieved when antenatal @entity288 are administered between 24h and 7 days before delivery. The objective of this study was to evaluate the occurrence of birth within seven days of @entity228 therapy in major obstetric situations with risk of preterm birthMETHODSRetrospective cohort study including 209 pregnant @entity1 hospitalized in risk of @entity3152 , submitted to @entity228 therapy for fetal lung maturation. The study was carried out between January 2012 and March 2014 at a university hospital. Main outcome measure was the number of @entity1 who delivered within 7 da ys after antenatal @entity228 administration. Two groups were defined according to the reason for starting @entity288 : threatened @entity3152 (Group APPT) and other indications for @entity228 therapy (Group RPPT). A Kaplan-Meier survival analysis was performed and a p value <0.05 was considered statistically significant.RESULTS46.4% (n=97) of pregnant @entity1 gave birth in the seven days following @entity228 administration. Delivery within 7 days occurred more frequently on group 2 in comparison to group 1 (57.3 versus42.4%; p=0.001). There is a statistically significant difference between the survival curve for groups 1 and 2, with a hazard ratio for delivery within 7 days 1.71 times higher for group 2 (95%CI 1.23-2.37; p<0.001)CONCLUSIONIt can be concluded that the probability of an event (birth within 7 days after @entity288 ) is smaller in the group of pregnant @entity1 admitted in the context of threatened @entity3152 than for other indications. The use of @entity288 in pregnant @entity1 admitted for suspected @entity3152 should be subject to rigorous clinical evaluation.

title: [Evaluation of XXXX administration in situations of suspected imminent @entity3152 : a retrospective cohort study in a tertiary centre].

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery', 'preterm labour', 'preterm labor']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['premature birth']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity228 :: (CHEBI:50858,Chemical) :: ['corticosteroid']


abstract: BACKGROUND: The aim of this prospective study was to compare the outcomes of @entity3330 treated by the @entity3 ( @entity3 ) in multiply injured and isolated @entity174 cases. METHODS: This study comprised 26 @entity1 (16 @entity1 , 10 @entity1 ), who had 27 @entity3330 . @entity1 were divided into two groups; @entity1230 (group I) or isolated @entity3330 (group II). The average Injury Severity Score of group I was 26.7. Operations were performed according to biological fixation principles in a submuscular manner. No bone grafting was performed to enhance the healing. The cases were evaluated based on the criteria of Schatzker-Lambert and the modified Hospital for Special Surgery (HSS) scoring system. RESULTS: The mean follow-up period was 25.8 months. Union was achieved in all cases. Two @entity1 in group I required d  bridement procedures due to @entity281 . One of them healed completely but the other did not. The average range of knee motion of groups I and II at the last control were 112.8 degrees and 121.8 degrees , respectively. The mean modified HSS scores were 73.9 and 79.9, respectively. There was no significant difference in the HSS scores or the range of knee motion. The time to full weight bearing was longer in group I owing to the concomitant injuries. CONCLUSIONS: We concluded that @entity3 is a useful method for comminuted supracondylar fractures with @entity1230 @entity1 as the results showed no significant differences when compared with those of @entity1 with isolated @entity3330 .

title: Successful results of minimally invasive surgery for comminuted supracondylar @entity3330 with @entity3 : comparative study of multiply injured and isolated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['deep infection']

entities_list: @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple trauma', 'multiple injuries']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['LISS', 'Less Invasive Stabilization System']

entities_list: @entity3330 :: ('MESH:D005264', 'Disease') :: ['distal femoral fracture', 'femoral fractures', 'distal femoral fractures']

answer: @entity3330 :: (MESH:D005264,Disease) :: ['femoral fractures']


abstract: UNASSIGNED: Interstitial triplications in conjunction with @entity8882 ( @entity8882 ) have been rarely reported. Here we report on a @entity1 with de novo triplication at 11q13.4-q14.3 and @entity8882 for 11q14.3-qter. Chromosomal analysis showed a karyotype of 46, XYqh+, der (11), and normal parental karyotypes. A single nucleotide polymorphism (SNP) array detected an 18.7   Mb copy number gain consistent with tetrasomy for 11q13.4-q14.3 (chr11:71,002,347 bp-89,725,167 bp, hg19) and absence of heterozygosity for a 45   Mb stretch on 11q and consistent with @entity8882 at 11q14.3-qter (chr11:89,843,477 bp-134,930,689 bp, hg19) in our @entity1 . FISH analysis using two probes on both sides of the tetrasomic region showed an inverted 11q13.4-q14.3 region between two direct oriented 11q13.4-q14.3 segments (11q13.4-q14.3::11q14.3-q13.4::11q13.4-qter). Previously reported features of duplication overlapping 11q13-q14 showed clinical variability. Our @entity1 presented with some of those frequently described features, such as @entity245 , @entity154 , and @entity4242 but without @entity299 . Moreover, our @entity1 had in addition a @entity75 ( @entity76 and partial absence of @entity6789 ) which has not been reported. To our knowledge, this is the sixth @entity1 reported an intrachromosomal triplication together with @entity8882 . Interstitial 11q duplication overlapping 11q13-q14 is associated with @entity717 / @entity245 , @entity4242 , and @entity154 but also other malformations.    2015 Wiley Periodicals, Inc.

title: De novo 11q13.4q14.3 tetrasomy with XXXX for 11q14.3qter.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['facial dysmorphism']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain anomaly']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['development delay']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['absence of cerebellar vermis']

entities_list: @entity6789 :: ('MESH:D061085', 'Disease') :: ['corpus callosum']

entities_list: @entity4242 :: ('MESH:D008831', 'Disease') :: ['microcephaly']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['intellectual disability']

entities_list: @entity8882 :: ('MESH:D024182', 'Disease') :: ['UPD', 'uniparental isodisomy', 'uniparental disomy']

answer: @entity8882 :: (MESH:D024182,Disease) :: ['uniparental isodisomy']


abstract: During orthodontic therapy, @entity1 frequently complain about @entity158 and discomfort, especially during insertion of fixed appliances. Skeletal anchorage using an interdental microimplant is a new concept in orthodontic treatment. The purpose of this study was to investigate differences and changes in the level of @entity158 among @entity1 in relation to orthodontic microimplant treatments. Forty microimplants were applied to the maxilla as skeletal anchors in the orthodontic treatment. The visual analog scale (VAS) was used to evaluate the @entity1 ' perception of @entity158 during this new modality treatment. The premolar extraction VAS core was used as a baseline for the complete orthodontic procedure. The mean VAS score was 35.8 mm at 24 h after premolar extraction. The mean VAS score for insertion and removal of the microimplant 24 h after the operation was 12.3 and 7.8 mm, respectively. Three months after removal of the skeletal anchors, the VAS score had decreased to 3.2 mm and was the same as with the traditional orthodontic treatment. By using the repeated-measure @entity3628 ( @entity3628 ), we found that the score 1 day after microimplant placement was significantly less than that 1 day after first premolar extraction or that 1 day after fixed appliance insertion. This result indicates that interdental microimplant did not generate any greater @entity158 than other orthodontic procedures. Therefore, @entity1 were willing to adopt the new orthodontic treatment.

title: The perception of XXXX following interdental microimplant treatment for skeletal anchorage: a retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3628 :: ('MESH:D004195', 'Disease') :: ['general linear model', 'GLM']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: Transport of ferric-siderophores across the outer membrane of gram-negative bacteria is mediated by specific outer membrane receptors. To localize the substrate-binding domain of the ferric-pseudobactin 358 receptor, PupA, of @entity15250 WCS358, we constructed chimeric receptors in which different domains of PupA were replaced by the corresponding domains of the related ferric-pseudobactin receptors PupB and PupX, or the @entity71221 receptor FhuE of @entity526 . None of the chimeric proteins composed of pseudobactin receptor domains facilitated growth on any of the original substrates, or they showed only an extremely low efficiency. However, these receptors enabled cells of @entity15250 BN8 to grow on media supplemented with uncharacterized siderophore preparations. These siderophore preparations were isolated from the culture supernatant of WCS358 cells carrying plasmids that contain genes of @entity15250 B10 required for the biosynthesis of pseudobactin B10. Hybrid proteins that contained at least the @entity1472 -terminal 516 @entity1522 of mature FhuE were active as a receptor for @entity71221 and interacted with the @entity526 TonB protein. A chimeric PupA-FhuE protein, containing the @entity1472 -terminal 94 @entity1472 acids of mature PupA, was also active as a @entity71221 receptor, but only in the presence of @entity15250 TonB. It is concluded that the @entity1473 -terminal domain of ferric-pseudobactin receptors is important, but not sufficient, for ligand interaction, whereas binding of @entity71221 by the FhuE receptor is not dependent on this domain. Apparently, the ligand-binding sites of different receptors are located in different regions of the proteins. Furthermore, species-specific TonB binding by the PupA receptor is dependent on the @entity1472 -terminal domain of the receptor.

title: Localization of functional domains in the XXXX @entity71221 receptor FhuE and the @entity15250 ferric-pseudobactin 358 receptor PupA.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity1473 :: ('CHEBI:46883', 'Chemical') :: ['carboxy']

entities_list: @entity15250 :: ('303', 'Species') :: ['Pseudomonas', 'Pseudomonas putida']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']


abstract: In previous studies, we have shown that ultraviolet (UV) B radiation perturbs the @entity1412 function of Langerhans cells (LC) by interfering with as-yet unidentified co-stimulatory signals. Recently, @entity12750 on @entity1412 were shown to deliver important co-stimulatory signals through interaction with their counter receptors @entity1361 and @entity4386 on T cells. To determine whether UVB affects the functional expression of @entity7938 or @entity2937 on LC, @entity12750 expression was studied on @entity1 LC by multiparameter flow cytometry. Little, if any, @entity7938 or @entity2937 was detected on LC freshly isolated from skin. However, following 48 h of tissue culture, expression of both @entity12750 were markedly up-regulated. To test whether these molecules were functional, primary mixed epidermal cell leukocyte reactions (MECLR) were performed. Blocking monoclonal antibody (mAb) to @entity7938 or @entity2937 both inhibited the MECLR, with anti- @entity2937 being much more effective than anti- @entity7938 . UVB radiation dose-dependently (100-200 J/m2) suppressed the culture-induced up-regulation of @entity7938 and @entity2937 on LC. Since LC exposed to the same UVB flux (UVB-LC) failed to stimulate alloreactive T cells in a MECLR, we questioned whether this was related to their inability to provide B7 co-stimulation. Indeed, when effective B7- @entity1361 signaling was ascertained by adding submitogenic doses of exogenous anti- @entity1361 mAb to UVB-LC, the proliferative response of alloreactive T cells was restored. We conclude that the suppressive effects of low-dose UVB radiation on the @entity1412 function of LC are, at least in part, due to an inhibition of functional @entity12750 expression.

title: Low-dose UVB radiation perturbs the functional expression of @entity12750 co-stimulatory molecules on XXXX Langerhans cells.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Although optimizing glycemic and non-glycemic targets reduced micro- and macro-vascular complications in @entity164 2 @entity6 , multiple barriers hinder turning evidence into practice. Mounting evidence suggests that those with onset of disease in early or mid-adult life, compared with those with onset at an older age, may have a more severe disease course and worse glycemic control. AIMS _ OBJECTIVE: We tested the hypothesis that those diagnosed at younger age would have worse glycemic control, even after adjustment for duration of @entity6 , higher BMI and other known risk factors for worse glycemic control. MATERIALS _ METHODS: A cross-sectional analysis of 560 @entity164 2 @entity6 subjects from North Indian populace in the year 1999-2012 who reported to endocrine clinic was performed. Sixty @entity1 did not report in the successive year and final data analyses were done in 500 @entity1 attending clinic regularly over a period of 10 years for evaluation of glycemic and non-glycemic targets. They were followed up at 3 monthly intervals with all @entity1 undergoing anthropometric measurement (BMI (weight in kg/height in m(2)), diet and lifestyle advice by a @entity6 educator and consultation by endocrinologist. Fasting and postprandial plasma @entity413 , A1c (3 monthly), besides evaluation of SMBG that was performed in 50% of these @entity1 regularly. Fasting lipids, S. @entity1011 and microalbuminuria were assessed annually and blood pressure recoding was done at each visit. The treatment was modified as per the investigation reports. We classified age at @entity6 diagnosis as younger (<60 years) vs older (>= 60 years). The primary outcome of interest was HbA1c >= 9%. Secondary outcomes were HbA1c >= 8% to <9% and HbA1c >= 7% to <8%. RESULTS: After adjustment for sex, duration of @entity6 , @entity1602 medications, BMI, co-morbid conditions, age <60 years at diagnosis remains significantly associated with greater odds of HbA1c >= 9% [OR 0.95(0.84-1.07)], HbA1c >= 8% to <9% [OR 1.04(0.93-1.15)] and HbA1c >= 7% to <8% [OR 1.05(0.85-1.17)] for female sex. Seventy two (72.7%) of @entity1 <60 years achieved BP <140/90mmHg (p<0.001) as compared to 62.3% of @entity1 >= 60 years who achieved BP <150/90mmHg (p<0.001) and LDL- @entity165 <100mg/dl in 33.7% @entity1 and 39.1% respectively (p<0.002). CONCLUSION: Younger age (<60 years) at @entity164 2 @entity6 diagnosis is significantly associated with worse subsequent glycemic control and lipid control, as younger @entity1 at diagnosis have fewer competing co-morbidities and complications. As @entity1 -centeredness is a priority in @entity164 2 @entity6 care, safe, aggressive and individualized treatment could benefit this higher-risk group.

title: Glycemic and non-glycemic targets in younger and older North Indian subjects with XXXX 2 @entity6 in a Tertiary care hospital: A 10 year's retrospective data analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: Recent studies reveal the role of the ankle retinacula in proprioception and functional stability of the ankle, but there is no clear evidence of their role in the outcomes of @entity3681 . 25 @entity1 with outcomes of @entity3681 were evaluated by MRI to analyze possible @entity16 . @entity1 with damage were subdivided into two groups: group A comprised cases with ankle retinacula damage only, and group B those also with anterior talofibular ligament rupture or @entity236 . Both groups were examined by VAS, CRTA and static posturography and underwent three treatments of deep connective tissue massage (Fascial Manipulation technique). All evaluations were repeated after the end of treatment and at 1, 3 and 6 months. At MRI, alteration of at least one of the ankle retinacula was evident in 21 subjects, and a further lesion was also identified in 7 subjects. After treatment, VAS and CRTA evaluations showed a statistically significant decrease in values with respect to those before treatment (p < 0.0001). There were also significant improvements (p < 0.05) in stabilometric platform results. No significant difference was found between groups A and B. The initial benefit was generally maintained at follow-up. The alteration of retinacula at MRI clearly corresponds to the proprioceptive damage revealed by static posturography and clinical examination. Treatment focused on the retinacula may improve clinical outcomes and stabilometric data.

title: RMI study and clinical correlations of ankle retinacula damage and outcomes of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow edema']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['damage to the ankle retinacula']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['ankle sprain']

answer: @entity3681 :: (MESH:D016512,Disease) :: ['ankle sprain']


abstract: PURPOSE: @entity172 receptor-positive (ER+) and -negative (ER) @entity0 are molecularly distinct diseases. We hypothesized that @entity876 mutations may lead to different transcriptional changes and carry different prognostic value in these two different types of @entity5 . EXPERIMENTAL DESIGN: We developed a 39-gene @entity876 signature derived from 213 ER+ and a separate 30-gene signature from 38 @entity5 with known mutation status and tested their prognostic and chemotherapy response predictive values in ER+ and @entity5 , respectively. RESULTS: External validation to predict @entity876 status (n = 103) showed sensitivity and specificity of 89% and 54% for the 39-gene signature, and 82% and 61% for the 30-gene signature. The 39-gene signature was predictive of worse distant @entity3 free survival in ER+ @entity5 in two separate prognostic data sets (n = 255, HR: 2.3, P = 0.005 and n = 198, HR: 2.17, P = 0.09). It also predicted for poor prognosis even with adjuvant @entity440 therapy (n = 277, HR = 2.43, P < 0.0001) but it was not prognostic in @entity5 . It was also associated with higher chemotherapy sensitivity in ER+ but not in @entity5 . The prognostic and predictive values remained significant in multivariate analysis. The 30-gene, ER-, @entity876 signature showed no prognostic or predictive values in ER+ @entity5 but it was associated with better prognosis in @entity5 . It also had no chemotherapy response predictive value in ER- or ER+ @entity5 . CONCLUSIONS: @entity876 dysfunction is prognostically most relevant in ER+ @entity5 and supports the hypothesis that different predictive or prognostic markers will be needed for different molecular subsets of @entity0 .

title: Distinct XXXX gene signatures are needed to predict prognosis and response to chemotherapy in ER-positive and ER-negative @entity0 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['Estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'ER- cancers']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: BACKGROUND: @entity740 ( @entity740 ) is associated with @entity2690 resistance (IR). Prior studies have found that in individuals with @entity740 , leptin is associated with fat mass but resistin is not and the associations with @entity1254 are conflicting. This suggests that the mechanism and factors associated with IR in @entity740 may differ. METHODS: Of the 2418 individuals without reported @entity6 at baseline, participating in the Health, Aging and Body Composition study, a study in older individuals aged 70-79 years, 15.6% had @entity740 defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2) based on cystatin C. IR was defined as the upper quartile of the homeostasis model assessment. The association of visceral and subcutaneous abdominal fat, percent body fat, muscle fat, lipids, inflammatory markers and @entity1254 were tested with logistic regression. Interactions were checked to assess whether the factors associated with IR were different in those with and without @entity740 . RESULTS: Individuals with IR had a lower eGFR (80.7    20.9 versus 75.6    19.6, P < 0.001). After multivariable adjustment, eGFR (odds ratio per 10 mL/min/1.73 m(2) 0.92, 95% confidence interval 0.87-0.98) and @entity740 (1.41, 1.04-1.92) remained independently associated with IR. In individuals with and without @entity740 , the significant predictors of IR were male sex, black race, higher visceral fat, abdominal subcutaneous fat and @entity1674 . In individuals without @entity740 , IR was associated with lower high-density lipoprotein and current nonsmoking status in multivariate analysis. In contrast, among individuals with @entity740 , @entity650 ( @entity650 ) was independently associated with IR. There was a significant interaction of eGFR with race and @entity650 with a trend for adionectin but no significant interactions with @entity740 (P > 0.1). In the fully adjusted model, there was a trend for an interaction with @entity1254 for eGFR (P = 0.08) and significant for @entity740 (P = 0.04 ), where @entity1254 was associated with IR in those without @entity740 but not in those with @entity740 . CONCLUSIONS: In mainly Stage 3 @entity740 , kidney function is associated with IR; except for @entity1254 , the correlates of IR are similar in those with and without @entity740 .

title: Correlates of XXXX resistance in older individuals with and without kidney disease.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD']

answer: @entity2690 :: (3630,Gene) :: ['insulin']