abstract: INTRODUCTION: We evaluated the feasibility of employing a self-expanding stent (Neuroform) in treatment of @entity2806 and compared the results of primary and secondary stenting. METHODS: We analyzed the treatment results of 14 acute @entity385 @entity1 (11 @entity1 and three @entity1 ; median age, 65  years) who were treated with Neuroform stents. Seven @entity1 received stent placement for primary recanalization and a further seven for secondary recanalization. We performed between-group comparisons of all of overall procedure duration, recanalization rate immediately after stenting, need for additional measures after stenting, final recanalization rate, occurrence of @entity548 , early re-occlusion rate after 24  h, and 3-month functional recovery rate ( @entity5329 ). RESULTS: The median interval from femoral puncture to stent placement was 61.5  min and was significantly shorter in the primary than in the secondary group (55 vs. 95  min, p   =   0.004). The recanalization rate immediately after stenting was 42.9% and was greater in the primary than in the secondary group (71.4% vs. 14.3%, p   =   0.1). Thirteen @entity1 required various additional therapeutic measures. The final recanalization rate was 78.6%, attributable to improvements in the recanalization rate of the secondary group (71.4% vs. 85.7%). Early @entity548 was noted in four @entity1 , but only one @entity1 became symptomatic (symptomatic @entity548 , 7.1%). Good functional recovery was noted in eight @entity1 (57.1%). CONCLUSION: Placement of a self-expanding stent during endovascular recanalization of acute @entity385 was both feasible and safe. Primary use of this method may enhance early recanalization.

title: Treatment of acute XXXX : feasibility of primary or secondary use of a self-expanding stent (Neuroform) during local intra-arterial thrombolysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic transformation', 'hemorrhage']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['acute cerebral ischemia']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: BACKGROUND: @entity1575 is a @entity1575 , and nodule formation. The @entity1810 ( @entity1810 ) and @entity13358 ( @entity13358 ) are very important cytokines in hepatic fibrogenesis. The aim of this study was to examine the relationship between the changes of the serum cytokines and morphological changes following common bile duct ligation in experimental @entity35 . METHODS: Common bile ducts of fifty male @entity35 were ligated and seven male @entity35 were set aside as controls. Five @entity35 each were sacrificed in 1, 2, 4, 6, 8, and 10 experimental weeks. Light microscopic studies and liver function tests were performed during the above experimental weeks. The levels of serum @entity1810 and @entity13358 were analyzed by ELISA. Also, @entity1918 ( @entity1918 ) immunohistochemical stains were performed. RESULTS: On the eighth week after common bile duct ligation, most hepatic lobular areas had been replaced by proliferated bile ducts and fibrous tissue (typical @entity2835 ). Serum @entity1810 levels between the control group and the common bile duct ligation group showed statistically significant changes. The @entity1918 was stained at proliferated bile ducts. These findings were correlated with each other. CONCLUSION: Thus, this experiment may clarify our understanding of the mechanism in liver fibrogenesis. Also, indicated is a need to explore the therapeutic potential of these cytokines as anti-fibrotic agents.

title: Changes in serum cytokine concentration: a morphological study of liver cirrhosis induced by common bile duct ligation in XXXX .

entities_list: @entity2835 :: ('MESH:D008105', 'Disease') :: ['biliary cirrhosis']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity1918 :: ('25365(Tax:10116)', 'Gene') :: ['alpha smooth muscle actin', 'alpha-SMA']

entities_list: @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['TGF-beta 1', 'transforming growth factor-beta 1']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['diffuse hepatic fibrosis', 'Liver cirrhosis']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Molecular evidence has recently suggested a number of different pathways leading to the development of @entity0 . The links between @entity1373 and low-grade @entity513 in @entity1137 and @entity1137 are well known pathologically, but high-grade in situ and invasive @entity189 appear to have a different biological oncogenetic pathway. Morphologically there is a similarity between apocrine cells and some cases of high-grade @entity513 . In order to investigate this possibility a number of different biological markers known to occur in high-grade @entity0 were assessed in both apocrine metaplasia (APM) and a putative @entity75 called apocrine change within sclerosing adenosis ( @entity5066 ). In 64 cases of APM and 18 cases of @entity5066 we examined for expression of @entity1722 , @entity876 , @entity588 , @entity589 , @entity517 and Ki-67 proteins using immunocytochemistry. @entity1722 expression was seen in 55.6% of @entity5066 cases and in 10.9% of APM cases. @entity876 expression was detected in 27.8% of @entity5066 cases but only 1.6% of APM cases. All cases of @entity5066 and APM were negative for the anti-apoptotic protein @entity588 , but all the APM and 33.3% of @entity5066 cases showed cytoplasmic positivity for @entity589 , a pro-apoptotic protein. All the cases of @entity5066 and APM were positive for @entity517 oncoprotein, however, the mean percentage of nuclear positivity was 50% in @entity5066 and 37% in cases of APM cases. The mean percentage positivity for Ki-67, a proliferation associated antigen, was 3.6% in @entity5066 and 1.3% in APM. The results indicate that a subset of breast lesions containing APM epithelium show abnormal oncoprotein and apoptosis-related protein expression and have a higher proliferation rate.

title: Expression of @entity1722 , @entity876 , XXXX , @entity589 , @entity517 and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast.

entities_list: @entity1137 :: ('MESH:D018275', 'Disease') :: ['situ and lobular neoplasia', 'lobular carcinoma']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['ductal carcinoma of the breast', 'breast carcinomas']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['premalignant lesion']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['atypical ductal hyperplasia']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma']

answer: @entity588 :: (596,Gene) :: ['Bcl-2']


abstract: UNASSIGNED: Both @entity385 ( @entity385 ) and @entity64 ( @entity64 ) are reported to occur due to @entity715 on the arteries of the brain. As @entity6 is a risk factor for @entity64 and insulin is reported to prevent @entity715 , the role of insulin in @entity385 and @entity64 was investigated. Forty eight @entity64 victims ( @entity385  =  22, @entity64  =  26) and equal number of aged and sex matched normal volunteers participated in the study. @entity842 was determined by methemoglobin method. Insulin and Dermcidin isoform-2 (DCN2) level was determined by ELISA by using insulin and dermcidin antibody. Insulin binding to the platelet membrane was analyzed by scat chard plot. Treatment of normal platelet rich plasma (10(8)platelets/ml) with 15 Units insulin/ml produced 1.41  nmol NO. The @entity21652 from the @entity385 and @entity64 victims produced 0.38  nmol NO and 0.08  nmol NO respectively. Pretreatment of @entity21652 from @entity385 or @entity64 subjects with 15   M @entity117 followed by 15 Units of insulin/ml resensitized the platelets to the inhibitory effect of insulin. @entity19 hepatocytes treated with 0.14   M DCN2 abolished the @entity413 induced insulin synthesis by NO that can be reversed by using 15   M @entity117 . It can be concluded that presence of DCN2 in @entity64 causes a condition similar to @entity1723 and nullified the effect of insulin in the inhibition of @entity1423 in both @entity385 and @entity64 . The effect was reversed by 15   M @entity117 .

title: The impaired synthesis of insulin and its inability to inhibit XXXX in cerebrovascular accident.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'HS', 'stroke', 'hemorrhagic stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['type I diabetes']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'IS']

answer: @entity1423 :: (MESH:D001791,Disease) :: ['platelet aggregation']


abstract: UNASSIGNED: In most animals, ageing is associated with a decline in immune function (immune senescence). However, different components of the immune system seem to age differentially, and many studies do not measure the ultimate fitness consequences of immune function after @entity281 . Previous work shows that immune function may be traded off with other fitness components such as reproduction. It is possible that age alters the nature of these trade-offs, particularly in conjunction with factors such as gender and mating that can also affect investment in immune function. We tested the impact of age, sex and mating on post- @entity281 survivorship in @entity5399 flour beetles, as well as the components of baseline constitutive innate immunity and external (secreted) immune function in uninfected individuals. We also tested whether the reproductive ability of uninfected females is traded off with immune function (baseline innate and external immunity) and post- @entity281 survivorship across age groups. We found that age, sex and mating significantly affected immune components and @entity281 outcome, although the magnitude and nature of the impact varied in each case. We found that older beetles were more susceptible to @entity281 by the pathogen @entity11137 even though major components of the constitutive innate immune defence (antibacterial and phenoloxidase activity) remained unchanged or improved with age. Thus, these aspects of innate immunity cannot explain the observed decline in post- @entity281 survival of older beetles. We did not find trade-offs between the reproductive ability of uninfected females and their immune function. In contrast to innate immunity, external immunity showed an overall decline with age but was also affected by sex and mating. Finally, we show that @entity2348 alters external immunity via complex interactions between age, sex and mating status. Our work uncovers novel interactions between age, sex and mating that can determine the evolution and outcome of immunosenescence by affecting the time course of relative investment in different immune and fitness components.

title: Immunosenescence and the ability to survive XXXX in the @entity5399 @entity5399 .

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity11137 :: ('1428', 'Species') :: ['Bacillus thuringiensis']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection']

entities_list: @entity5399 :: ('7070', 'Species') :: ['Tribolium castaneum']

answer: @entity2348 :: (MESH:D001424,Disease) :: ['bacterial infection']


abstract: Mechanisms related to increased left ventricular filling pressure associated with @entity741 were studied in 13 @entity1 with @entity453 . Single-plane left ventriculograms were obtained using a high fidelity micromanometer-tipped catheter in the control and post-pacing periods. All @entity1 developed typical @entity158 during pacing @entity591 . Seven @entity1 (group I) demonstrated no significant changes in ejection fraction (EF) and peak systolic pressure-end-systolic volume ratio (P/Ves) after rapid pacing. End-diastolic pressure (EDP), however, increased significantly from 14.9 +/- 4.9 to 24.4 +/- 8.5 mmHg (p less than 0.01). Six @entity1 (group II) exhibited significant decreases in EF and P/Ves. Here again, EDP increased significantly from 14.0 +/- 7.6 to 28.0 +/- 7.7 mmHg (p less than 0.01). The regional myocardial function was expressed by a radial coordinate system with its origin at the center of gravity of the end-diastolic contour. In the normal segment, the end-diastolic length (EDL) was augmented by 13.6%, associated with a 22.4% increase in @entity64 excursion with pacing stress. In the @entity63 segment, EDL remained unchanged, but @entity64 excursion was significantly reduced. The diastolic pressure-volume curve shifted directly upward or more to the right, while the diastolic pressure-length curve moved up on the single curve in the normal segment and shifted directly upward in the @entity63 segment, so that pressure was higher at any given segment length in the @entity63 segment, indicating regional alteration of the diastolic properties. Thus, an @entity63 response to pacing @entity591 involves both @entity7099 , but the latter is more sensitive.(ABSTRACT TRUNCATED AT 250 WORDS)

title: An analysis of regional left ventricular function utilizing pressure-length relationship in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['anginal pain']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity7099 :: ('MESH:C564174', 'Disease') :: ['systolic and diastolic impairment']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: PURPOSE: @entity151 ( @entity151 ) has a poor prognosis, and current salvage chemotherapy for refractory @entity151 , such as @entity3895 ( @entity786 , @entity632 , @entity1891 ) or @entity1945 , has an unsatisfactory outcome, with a response rate and overall survival of less than 10% and 6 months, respectively. This phase II study evaluated the role of @entity1945 combined with @entity2879 in @entity151 @entity1 that have progressed, or relapsed, within 3 months following completion of the initial chemotherapy. MATERIALS AND METHODS: Twenty-seven @entity1 were entered into this study. Eligible @entity1 had an ECOG performance status of less than, or equal to, 2, at least one bidimensionally measurable lesion and adequate end organ function. IV @entity1945 , 1.0 mg/m2/d for 5 consecutive days, and @entity2879 , 100 mg/m2/d through days 1 to 3, were administered every 3 weeks until disease progression or undue @entity137 . RESULTS: The major @entity137 was myelosuppression. Grade 3/4 @entity417 , @entity3028 , and thrombocy-topenia occurred in 14.2, 34.8, and 27.3% of cycles, respectively. There was no treatment-related @entity204 , and other non-hematologic @entity137 were generally mild. Four @entity1 achieved partial responses, with a response rate RR of 14.8%. The progression-free survival PFS ranged from 1 to 7 months, with a median of 2.0 months (95% confidence interval 1.22~2.78 months). Twenty-five @entity1 died, with a median overall survival of 5.5 months (ranging from 1 to 21 months, 95% CI 4.32~6.68 months), and the 6-month survival rate was 32.1% (95% confidence interval 14.4~49.8%). CONCLUSION: The combination of @entity1945 and @entity2879 chemotherapy showed a modest response rate, but failed to prolong survival of refractory @entity151 @entity1 compared to @entity1945 monotherapy.

title: Phase II Study of @entity1945 and XXXX as Second-line Treatment in Chemotherapy-refractory Small-cell Lung Cancer.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['Refractory small-cell lung cancer', 'SCLC']

entities_list: @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia']

answer: @entity2879 :: (MESH:D005047,Chemical) :: ['Etoposide']


abstract: The @entity238 mutants amnesiac, @entity36379 ( @entity36379 ), and rutabaga were isolated after associative conditioning tests, during which animals were trained to associate the presence of an odor with that of @entity1457 ( @entity1457 ). In the absence of conditioning, the odor avoidance (OA) of these mutants was shown to be normal, indicating that their poor associative conditioning performance was attributable to specific @entity4207 . However, I show that the OA of the mutants is greatly decreased after their exposure to @entity1457 . This effect can last for hours. These results strongly suggest that part of the defect displayed by these mutants in associative conditioning tests does not correspond to a @entity4207 but might arise from abnormal sensitivity to stressful stimuli. I looked at the OA after @entity1457 of two previously characterized @entity36379 mutants. Df(1)N79f specifically decreases @entity36379 expression in the mushroom bodies, leading to a normal level of learning but decreased memory. Df(1)N79f mutants displayed a normal OA after @entity1457 . Df(1)N64j15 affects the entire brain expression of @entity36379 , leading to decreased learning and memory. Df(1)N64j15 animals showed a strong decrease of their OA after @entity1457 . Thus, the lack of @entity36379 "general" expression is most likely responsible for the @entity1314 , which would be responsible for the apparent @entity4207 after conditioning. In contrast, the @entity36379 phosphodiesterase accumulated in the mushroom bodies would be involved specifically in memory formation.

title: Decreased odor avoidance after electric shock in XXXX mutants biases learning and memory tests.

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['ES', 'electric shocks']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning or memory deficits', 'learning defect', 'learning or memory deficit']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity238 :: (7227,Species) :: ['Drosophila']


abstract: There is evidence that the @entity1066 is associated with rectal prolapse either overt or internal. The anterior rectal wall is affected in most cases and a modified abdominal rectopexy has been used with the aim of supporting both the anterior and posterior aspects of the rectum. Fourteen @entity1 aged 19-70 years (mean 34.2 years) in whom conservative treatment has failed, have been treated by anteroposterior rectopexy. Tenesmus, @entity548 and the passage of mucus have been abolished or greatly improved in 12, 14 and 13 @entity1 respectively. The number of attempts to defaecate per 24 h has fallen from 8.7 +/- 1.4(s.e.m.) pre-operatively to 3.4 +/- 1.0(s.e.m.) postoperatively (P less than 0.05) and the time spent in the lavatory has been reduced from 146 +/- 18(s.e.m.) min to 15 +/- 3(s.e.m.) min. Two @entity1 have developed severe @entity1142 postoperatively and two others have had persistent or recurrent tenesmus. Combined anteroposterior rectopexy has improved 12 out of 14 @entity1 with the solitary @entity1066 without external rectal prolapse when assessed at 2-48 months postoperatively.

title: Anteroposterior rectopexy in the treatment of XXXX without overt rectal prolapse.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer syndrome', 'solitary rectal ulcer syndrome']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity1066 :: (MESH:D014456,Disease) :: ['solitary rectal ulcer syndrome']


abstract: @entity1892 ( @entity1892 ) is classified as @entity706 and various entities using the gene expression of proteins are classified into three groups. The aim of this study was to clarify the clinical, biological, immunophenotypic and cytogenetic features of @entity1892 with translocation t (14; 18) and 8q24/ @entity517 . Eleven @entity1892 @entity1 with dual translation were monitored during the 2000-2009 period. The characteristics of these @entity1 included morphological, immunohistochemical and cytogenetic analysis. Study results showed that all @entity1 had aggressive characteristics, presence of B symptoms (64%), general @entity1 condition according to ECOG scale >=  2 (55%), elevated serum @entity880 dehydrogenase activity (73%), clinical stage III and IV (82%), extranodal involvement of the disease (73%), and IPI >=  2 (73%). Partial remission was achieved in 73% of all @entity1 and all @entity1 (73%) died within a short time. @entity1 were treated with @entity3726 and similar protocols (COP, CVP, CNOP), with the addition of MabThera. Immunophenotyping was performed and determined expression of the @entity2225 , CD3, @entity2282 , @entity4042 and @entity14546 markers. The cytogenetic analysis/fluorescence in situ hybridization revealed complex karyotype changes. Thus, we analyzed the presence of @entity588 , @entity4042 and @entity517 genes and found eight @entity1 to have @entity588 and @entity517 translocation genes, while three had translocation of the @entity4042 and @entity517 genes. Despite appropriate therapy, the @entity1 prognosis is poor. The median survival in these @entity1 was 1.85 years. @entity1892 with @entity588 and @entity517 rearrangement of the subgroups of @entity706 is associated with very poor survival. The presence of these two translocations has an aggressive clinical course.

title: [Clinical features in XXXX and translocation @entity588 / @entity517 "double hit" @entity706 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'Diffuse large B-cell lymphoma']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

answer: @entity1892 :: (MESH:D016393,Disease) :: ['DLBCL']


abstract: Persistent clinical @entity644 (i.e., urinary protein excretion greater than 0.5 g/24 h) is an ominous development in a @entity1 with @entity6 . It eventually leads to a decline in the glomerular filtration rate and ultimately to @entity454 or premature cardiovascular mortality. Progression of @entity8 appears to be related to arterial blood pressure and protein intake and is primarily independent of the metabolic state. More sensitive immunoassays for detecting low concentrations of albumin in urine have led to recognition of subclinical increases in albumin excretion rates in nonclinically proteinuric @entity6 @entity1 , a phenomenon named microalbuminuria. Studies have shown that @entity1 with microalbuminuria have a significantly increased risk for clinical @entity644 and cardiovascular mortality. Microalbuminuria is rarely found during the first 5 yr of a @entity1 's @entity6 , suggesting that it is a sign of early @entity8 rather than a marker for susceptibility to it. In @entity1 with @entity2175 ( @entity2175 ), an association has been found between microalbuminuria and @entity301 , but this relationship needs further investigation. In @entity1 with @entity1723 ( @entity1723 ), this subclinical form of @entity644 is associated with poor metabolic control and, more important, with marginal elevation of blood pressure. Correction of @entity4854 by intensified insulin treatment might arrest progression to persistent clinical @entity644 ; moreover, restricted protein intake and lowering of blood pressure have been shown to reduce the albumin excretion rate.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Etiology and prognostic significance of albuminuria in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease', 'glomerular damage']

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['NIDDM', 'non-insulin-dependent diabetes mellitus']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['IDDM', 'insulin-dependent diabetes mellitus']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal failure']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: @entity571 , the most common form of @entity625 , influences a @entity1 's mental well-being, ability to work or perform activities of daily living, and personal and family relationships. Ideally, the management of this disease is multidisciplinary, involving not only the use of medication but also exercise instruction, dietary counseling, and psychosocial interventions. The effects of such a comprehensive treatment program have not been well studied. A 12-week trial of multidisciplinary assessment and management of @entity571 was conducted. In addition to receiving the anti-inflammatory agent sulindac, @entity1 were evaluated and followed up by health professionals in the disciplines of medicine, physical therapy, occupational therapy, nutrition, social work, and psychology. An initial assessment of the degree of @entity158 , @entity4 , @entity925 , stiffness, and ability to conduct activities of daily living was made, which represented @entity1 ' entry status. Subsequent assessments were made by the multidisciplinary team every two weeks for 12 weeks. Seventy-seven @entity1 completed at least ten of the 12 weeks. On entering the study, two thirds of the @entity1 had @entity158 , @entity925 , or @entity4 affecting the hip, knee, or hand. At the end of 12 weeks, 80% of the @entity1 had improvement in their @entity571 , and 71% improved in their ability to conduct activities of daily living. The results support the view that a comprehensive @entity571 can significantly reduce disability and @entity158 .

title: Medical aspects of the multidisciplinary assessment and management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['approach to osteoarthritis', 'osteoarthritis', 'Osteoarthritis']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['tenderness']

answer: @entity571 :: (MESH:D010003,Disease) :: ['osteoarthritis']


abstract: Before considering the possible biases discussed above, the results as reported in the current literature may indicate an advantage for radical prostatectomy in disease specific survival at 10 years' follow-up when compared with external radiation therapy and deferred treatment. It appears that most of the obvious biases found in the literature work in favour of radical prostatectomy. The actual advantage of radical prostatectomy with respect to disease specific survival at 10 years may therefore be less than the data complications suggest. The magnitude of these biases is, however, impossible to assess. A probable but perhaps marginal benefit for the majority of the @entity1 must, however, be put in relation to possible side effects and long term complications of the various treatments as well as the @entity1 's preferences when choosing treatment. Reliable controlled data on outcome and quality of life for the various treatments of @entity263 are needed, but we may have to wait for many years for such data. It must also be remembered that the results presented in this overview derive from a series started in the late 1970s of @entity1 treated with the surgical techniques and radiotherapy technology available at that time. Today, the frequent use of @entity1486 in early detection or screening programmes will definitely detect a larger number of low @entity263 that may be more curable by surgery or radiotherapy. This, however, remains to be proved. Moreover, new technology in radiotherapy, such as conformal therapy, may enable radiotherapists to deliver higher local doses of radiation to the prostate, which in turn may improve the cure rate for radiotherapy.

title: Radical prostatectomy, radiotherapy or deferred treatment for XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer', 'volume prostate cancers']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate specific antigen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['localized prostate cancer']


abstract: The effect of @entity1068 metabolism on the energetic parameters and intracellular pH of the isolated perfused @entity35 liver from fed @entity35 was studied by @entity9715 nuclear magnetic resonance spectroscopy. This technique allowed us to analyze nondestructively and in real time the role of low @entity26 tension on the possible injurious effect of @entity1068 on the liver cells. A quantitative analysis of nuclear magnetic resonance data recorded on a perfused @entity35 liver within a 30 mm diameter probe has been performed at 80.9 MHz. Under normoxic and normothermic conditions, the levels of phosphorylated metabolites detected by nuclear magnetic resonance were 2.8, 0.3 and 2 mumoles per gm liver wet weight for @entity855 , @entity857 and inorganic @entity6546 , respectively. The cytosolic pH was 7.25 +/- 0.05. During a period of 4 min of @entity519 induced by reducing the perfusion flow rate to 25% of its initial value (i.e., from 12 ml to 3 ml per min per 100 gm body weight), the level of @entity855 dropped to 2.2 mumoles per gm liver wet weight. Concomitantly, @entity857 and inorganic @entity6546 increased to 0.6 and 3.3 mumoles per gm liver wet weight. Cytosolic pH fell to 7.02 +/- 0.05. Perfusion of the liver with a Krebs medium containing 70 mM (0.4%) @entity1068 induced a sharp decrease in intracellular inorganic @entity6546 to reach 1.3 mumole per gm liver wet weight and after a lag time of 4 to 6 min, a decrease in @entity855 level (2.15 mumoles per gm liver wet weight). A large increase in phosphomonoesters (mainly @entity53200 ) up to 6 mumoles per gm liver wet weight was also observed.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Hepatic metabolism during acute @entity1068 administration: a @entity9715 nuclear magnetic resonance study on the perfused XXXX liver under normoxic or @entity519 conditions.

entities_list: @entity6546 :: ('MESH:D010710', 'Chemical') :: ['orthophosphate']

entities_list: @entity9715 :: ('CHEBI:37971', 'Chemical') :: ['phosphorus-31']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity53200 :: ('CHEBI:15978', 'Chemical') :: ['sn-glycerol 3-phosphate']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: To examine the characteristics of the plantar pressure distribution patterns during mid-stance phase of the gait cycle in subjects with chronic non-specific @entity1643 and asymptomatic subjects. MATERIAL AND METHOD: Twenty-three males and 17 females with chronic non-specific @entity1643 and age- and gender-matched asymptomatic subjects walked barefoot along a gait mat at comfortable speedfor three trials. The left and right plantar pressure distributions were recorded during mid-stance phase and divided into 12 areas. Descriptive statistics including mean and standard deviation of demographic data and plantar pressure were calculated, and plantar pressure distribution patterns were described. RESULTS: Mean and standard deviation of @entity158 rating scale of chronic non-specific @entity1643 group were 4.04  1.58. The average mean peak pressure of both chronic non-specific @entity1643 and asymptomatic subjects located at the fifth area (lateral aspect offorefoot) in both feet. However the modes of the peak pressure of subjects with chronic non-specific @entity1643 were in the different areas in the left and right feet. The distribution patterns of the average mean peak pressure were not the same in chronic non-specific @entity1643 and asymptomatic subjects. This altered foot contact in the subjects with chronic non-specific @entity1643 may be used to avoid @entity158 or to compensate for limited mobility of the lower limbs at pre-swing phase. CONCLUSION: At mid-stance phase of walking, the pressures on the plantar surface were unequally distributed in subjects with chronic non-specific @entity1643 .

title: Plantar Pressure Distribution Pattern during Mid-Stance Phase of the Gait in Patients with Chronic Non-Specific Low Back XXXX .

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'numeric pain']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: We examined the effects of bronchoalveolar lavage (BAL) and BAL fluid characteristics on the systemic proinflammatory cytokine expression and their relation to clinical and laboratory findings. Thirty @entity1 suspected to have @entity2 were subjected to fiber-optic bronchoscopy (FOB) and BAL. Clinical and laboratory findings were determined at baseline, 4 h, and 24 h, including lung auscultation, temperature, chest X-ray, WBC, neutrophils, and serum @entity1356 , @entity650 , and @entity310 . BAL fluid characteristics were determined including cytokine levels. Fifteen volunteers served as controls to determine serum variation of the same cytokines. Significant temperature elevation was defined as 1 degrees C increase compared to baseline. BAL was associated with temperature and serum @entity310 and @entity650 but not @entity1356 increase at 4 h. Four @entity1 (13.3%) developed temperature over 38 degrees C. In controls there were no significant changes between baseline and 24 h measurements for the same cytokines. Eleven @entity1 (36.6%) developed a significant temperature elevation 4 h after BAL. These @entity1 had a statistically significant ( p < 0.05) increase in serum @entity650 at 4 h and in @entity310 at both 4 and 24 h after BAL compared with the nonsignificant temperature increase group. BAL characteristics were not different between the two groups. On the other hand, BAL fluid @entity650 and @entity310 levels were significantly higher ( p < 0.05) in the nonfever group. Significant temperature increase was observed in 36.6% of the @entity1 undergoing BAL and associated with significant serum @entity310 and @entity650 increase at 4 h. Lung cytokines levels, alveolar macrophages, and BAL fluid characteristics are not related to temperature and serum proinflammatory cytokine increase. The hypothesis of alveolar macrophages derive from cytokine production and shift to the systemic circulation cannot be supported by our data.

title: Temperature and serum proinflammatory cytokine changes in XXXX with NSCLC after BAL.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The central nervous system has limited capacity for regeneration after @entity130 . Transplantation of neural stem/progenitor cells (NPCs) has been proposed as a potential therapeutic approach while @entity7424 ( @entity7424 ) has neuroprotective properties following various experimental insults to the nervous system. We have previously shown that NPCs transduced with a lentiviral vector for @entity7424 overexpression have an enhanced ability to give rise to neurons in vitro but also in vivo, upon transplantation in a @entity19 model of @entity1315 . Here we studied the regenerative potential of NPCs, @entity7424 -transduced or not, in a @entity19 model of @entity131 . NPC transplantation, with or without @entity7424 transduction, rescued the injury-induced @entity4207 as revealed in the Morris Water Maze. Moreover, it had beneficial effects on the host tissue by reducing astroglial activation and microglial/macrophage accumulation while enhancing generation of endogenous oligodendrocyte precursor cells. One or two months after transplantation the grafted NPCs had migrated towards the lesion site and in the neighboring myelin-rich regions. Transplanted cells differentiated toward the oligodendroglial, but not the neuronal or astrocytic lineages, expressing the early and late oligodendrocyte markers @entity5233 , @entity18900 , and @entity31247 . The newly generated oligodendrocytes reached maturity and formed myelin internodes. Our current and previous observations illustrate the high plasticity of transplanted NPCs which can acquire injury-dependent phenotypes within the host CNS, supporting the fact that reciprocal interactions between transplanted cells and the host tissue are an important factor to be considered when designing prospective cell-based therapies for CNS degenerative conditions. GLIA 2016;64:763-779.

title: Neural stem/progenitor cells differentiate into oligodendrocytes, reduce inflammation, and ameliorate @entity4207 after transplantation in a @entity19 model of XXXX .

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal mechanical injury']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['spatial learning deficits']

entities_list: @entity7424 :: ('16000(Tax:10090)', 'Gene') :: ['insulin-like growth factor I', 'IGF-I']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: PURPOSE: Bone scan is performed as part of the evaluation of bone @entity3 . We assessed the diagnostic value of bone scan in @entity1 with @entity1358 . MATERIALS AND METHODS: Bone scan was performed at presentation in 205 @entity1 with confirmed @entity1358 . Abnormal hot areas were further evaluated by x-ray, computerized tomography or surgery. RESULTS: Of the 56 @entity1 (27%) with an abnormal bone scan 32 (57%) had osseous metastatic lesions. Overall bone @entity3 was present in 34 of the 205 @entity1 (17%). Bone scan had 94% sensitivity and 86% specificity. Of the 124 @entity1 with clinically localized, stages T1-2N0M0 disease exclusive of bone @entity3 6 (5%) had bone @entity3 only, whereas 28 of 81 (35%) with locally advanced or @entity3 had bone @entity3 , including 12 (35%) who complained of @entity158 and 19 (56%) who presented with other symptoms due to local @entity5 growth or @entity3 at other sites. Three @entity1 (9%) were asymptomatic. There was osseous @entity3 without other @entity3 , enlarged regional lymph nodes or @entity158 in 7 @entity1 , including 1 with stage T1b (2% of all with that stage), 2 with stage T2 (5%), 1 with stage T3a (4%), 1 with stage T3b (6%), 1 with stage T3c (14%) and 1 with stage T4 (6%) disease. CONCLUSIONS: Bone scan may be omitted in @entity1 with stages T1-3aN0M0 @entity5 and no @entity158 because of the low proportion of missed cases with bone @entity3 .

title: The diagnostic value of bone scan in @entity1 with XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['bone pain']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastatic disease']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']


abstract: OBJECTIVE: To assess levels of @entity148 , @entity308 , loneliness, burnout and job satisfaction among paediatric Residents, and how they influence each other. METHODS: The cross-sectional study was conducted at Necmettin Erbakan University, Meram, and Konya Meram Education and Research Hospital, @entity233 from January to June 2011, and comprised paediatric Residents and their counterparts from other departments who formed the control group. While maintaining confidentiality, a questionnaire was used to collect data that had elements of the University of California, Los Angeles, Loneliness Scale, Hospital Anxiety and @entity308 Scale, Maslach Burnout Inventory and Minnesota Job Satisfaction Questionnaire. SPSS version 13 was used for statistical analysis. RESULTS: Overall there were 74 Residents in the study; 43 (58%) working with the paediatrics department, and 31 (42%) in the control group. Overall mean age was 27.60    2.25 years. Residents who were not satisfied with the city they were living in, with their professional career and who would not choose the same career given a second chance were feeling more lonely and had higher loneliness scores (p < 0.05). In contrast, @entity148 among female Residents who were unsatisfied with their professional career and working conditions was significantly high (p < 0.05). Positive correlation was detected between the burnout levels of Residents and their @entity148 , @entity308 and loneliness scores (r = 0.74; r = 0.65; r = 0.36). In terms of @entity14783 , there was an obvious negative correlation (r = -0.57; r = -0.54; r = -0.61). CONCLUSION: Working conditions and professional liability were the main factors affecting the Residents. Informed decision and career willingness may help them feel better.

title: A sample of paediatric residents' XXXX with probable affecting factors.

entities_list: @entity14783 :: ('MESH:D007589', 'Disease') :: ['intrinsic, extrinsic and total job satisfaction']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['loneliness-anxiety-depression-burnout and job satisfaction']


abstract: The reproducibility of motor unit twitches obtained using spike-triggered averaging (STA) was examined in the @entity1 first dorsal interosseus. For each motor unit (30 total) a series of STA twitches was derived using a 30 s averaging window. Within each averaging window, eight independent measures characterizing motor unit discharge and whole muscle force properties were recorded. These included the mean and standard deviation (S.D.) of the interspike interval (ISI), the mean and S.D. of pre and post-trigger ISIs used in averaging, and mean and S.D. of whole muscle force. To determine the relative importance of the independent variables on twitch reproducibility, the variables were used in a multiple regression analysis performed on STA twitch peak force (PF), @entity1054 ( @entity1054 ) and time of @entity1547 ( @entity1547 ). It was found that PF was significantly correlated to the mean and S.D. of whole muscle force, and mean post-trigger ISI. @entity1054 was significantly correlated to the S.D. of the post-trigger ISI and mean whole muscle force while @entity1547 was related to the mean and S.D. of the pre-trigger ISI and the mean post-trigger ISI. It was concluded that by minimizing whole muscle force variability and the mean and S.D. of acceptable ISIs used in the STA process, the reproducibility of the STA twitch is improved.

title: Factors affecting the stability of the spike-triggered averaged force in the XXXX first dorsal interosseus muscle.

entities_list: @entity1547 :: ('MESH:D003731', 'Disease') :: ['HFD', 'half-force decay']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['TTP', 'time to peak force']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The following results can be derived from the clinical and radiobiological literature as well as from the authors's own experiences with 91 @entity1 analyzed retrospectively and evaluated with respect to their risk factors. 1. A postoperative irradiation is very probably sensible in @entity1 with @entity5 perforation through the renal capsule (T3/T4) and with venous or lymph node manifestations. 2. The operation method is essential, above all the transabdominal technique and the quality of lymph dissection. 3. Prospective studies are necessary in order to clear up the role of radiotherapy in @entity1 with lymph node manifestations and the other two risk factors mentioned in item 1. 4. Further studies on the @entity5 biology of the @entity1358 are necessary in order to gain prognostic criteria allowing a pretherapeutic sensitivity recognition. 5. The effect of a supplementary radiotherapy can be only that of local recurrence prevention in case of a locally advanced @entity5 and the absence of demonstrable remote @entity3 . This seems justified, because the local recurrence rate in our own @entity1 was only 3.3%.

title: [The role of postoperative radiotherapy in the treatment of XXXX ].

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['hypernephroid carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['hypernephroid carcinoma']


abstract: BACKGROUND: The WHODAS 2.0 is an ICF-based multidimensional instrument developed for measuring disability. The present study analyzes the utility of the 36-item interviewer-administered version in a sample of @entity1 with @entity162 . There is no study to date that analyses how the scale works in a sample that only comprises such @entity1 . METHODS: A total of 291 @entity1 with @entity162 (42.6% males) according to DSM-IV-TR criteria from a cross-sectional study conducted in outpatient @entity146 clinics were enrolled. In addition to the WHODAS 2.0, @entity1 completed a comprehensive assessment battery including measures on psychopathology, functionality and quality of life. Analyses were centered on providing evidence on the validity and utility of the Spanish version of the WHODAS 2.0 in @entity162 @entity1 . RESULTS: Participation domain had the highest percentage of missing data (2.7%). Confirmatory factorial analysis was used to test three models formulated in the literature: six primary correlated factors, six primary factors with a single second-order factor, and six primary factors with two second-order factors. The three models were plausible, although the one formed by six correlated factors produced the best fit. Cronbach's alpha values ranged between .73 for the Self-care domain and .92 for Life activities, and the internal consistency of the total score was .96. Relationships between the WHODAS 2.0 and measures of psychopathology, functionality and quality of life were in the expected direction, and the scale was found to be able to differentiate among @entity1 with different intensity of clinical symptoms and work situation. LIMITATIONS: The percentage of euthymic @entity1 was considerable. However, the assessment of euthymic @entity1 is less influenced by mood. Some psychometric properties have not been studied, such as score stability and sensitivity to change. CONCLUSIONS: The Spanish version of the 36-item WHODAS 2.0 has suitable psychometric properties in terms of reliability and validity when applied to @entity1 with @entity162 . Disability in @entity162 @entity1 is especially prominent in Cognition, Getting along, Life activities, and Participation domains, so functional remediation interventions should emphasize these areas in order to improve the daily living activities of these @entity1 .

title: Disability in XXXX : The 36-item World Health Organization Disability Assessment Schedule 2.0.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar', 'bipolar disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar I disorder']


abstract: OBJECTIVE: The aim of this study was to compare semiexperimentally the pulse oximetry values obtained from a finger on restrained or unrestrained sides of the body. BACKGROUND: The pulse oximeter provides a noninvasive measurement of the @entity26 saturation of hemoglobin in arterial blood. One of the procedures most frequently applied to @entity1 in intensive care units is the application of physical restraint. Circulation problems are the most important complication in @entity1 who are physically restrained. Evaluation of @entity26 saturation from body parts in which circulation is impeded or has deteriorated can cause false results. METHODS: The research sample consisted of 30 hospitalized @entity1 who participated in the study voluntarily and who were concordant with the inclusion criteria of the study. @entity1 information and @entity1 follow-up forms were used for data collection. Pulse oximetry values were measured simultaneously using OxiMax Nellcor finger sensors from fingers on the restrained and unrestrained sides of the body. Numeric and percentile distributions were used in evaluating the sociodemographic properties of @entity1 . RESULTS: A significant difference was found between the @entity26 saturation values obtained from a finger of an arm that had been physically restrained and a finger of an arm that had not been physically restrained. The mean @entity26 saturation value measured from a finger of an arm that had been physically restrained was found to be 93.40 (SD, 2.97), and the mean @entity26 saturation value measured from a finger of an arm that had not been physically restrained was found to be 95.53 (SD, 2.38). CONCLUSIONS: The results of this study indicate that nurses should use a finger of an arm that is not physically restrained when evaluating @entity26 saturation values to evaluate them correctly.

title: Comparison of XXXX saturation values obtained from fingers on physically restrained or unrestrained sides of the body.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'patient']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: BACKGROUND _ AIMS: To develop an individual prognostic calculator for @entity1 with unresectable @entity157 ( @entity157 ) undergoing trans-arterial chemo-embolization (TACE). METHODS: Data from two prospective databases, regarding 361 @entity1 who received TACE as first-line therapy (2000-2012), were reviewed in order to refine available prognostic tools and to develop a continuous individual web-based prognostic calculator. @entity1 with neoplastic portal vein invasion were excluded from the analysis. The model was built following a bootstrap resampling procedure aimed at identifying prognostic predictors and by carrying out a 10-fold cross-validation for accuracy assessment by means of Harrell's c-statistic. RESULTS: Number of @entity5 , serum albumin, serum total @entity648 , alpha-foetoprotein and maximum @entity5 size were selected as predictors of mortality following TACE with the bootstrap resampling technique. In the 10-fold cross-validation cohort, the model showed a Harrell's c-statistic of 0.649 (95% CI: 0.610-0.688), significantly higher than that of the @entity1416 Prognostic (HAP) score (0.589; 95% CI: 0.552-0.626; P = 0.001) and of the modified HAP-II score (0.611; 95% CI: 0.572-0.650; P = 0.005). Akaike's information criterion for the model was 2520; for the mHAP-II it was 2544 and for the HAP score it was 2554. A web-based calculator was developed for quick consultation at http://www.livercancer.eu/mhap3.html. CONCLUSIONS: The proposed individual prognostic model can provide an accurate prognostic prediction for each @entity1 with unresectable @entity157 following treatment with TACE without class stratification. The availability of an online calculator can help physicians in daily clinical practice.

title: Refining prognosis after trans-arterial chemo-embolization for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['Hepatoma Arterial-embolization']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: OBJECTIVES: We aimed to determine the efficacy of an 8-week direct blood pressure (BP) biofeedback training program for @entity1556 or stage I @entity101 @entity1 with a particular focus on the impact of the authenticity of feedback signals on the efficacy of BP regulation. DESIGNS: This study has a randomized, double-blind, parallel-group design. @entity1 AND METHODS: Fifty-nine individuals with ages from 18 to 64 years and who met the criteria for the diagnosis of prehypertenion or stage 1 @entity101 participated in this study. The @entity1 were referrals from physicians or community-dwelling volunteers. No @entity1 had taken antihypertensive medication within the previous 2 months prior to enrollment. The @entity1 were randomly assigned to the biofeedback group (n = 31) trained with real-time BP feedback signals or the control group (n = 28) trained with pseudofeedback signals. The primary outcome measures were @entity13519 (DBP). Systolic BP and DBP were assessed at baseline, 1 week after training (week 9), and 8 weeks after training (week 16) in both groups. Only 54 @entity1 had week 16 data. RESULTS: The changes in @entity13519 and DBP from baseline to week 9, from baseline to week 16, and from week 9 to week 16 were not significantly different between the groups (All P > 0.05). Both groups were able to significantly decrease BP after completing the training. A percentage of 45.2% of the @entity1 in the biofeedback group and 63.0% of the @entity1 in the control group lowered their @entity13519 by 5 mm Hg or more at week 9. The @entity13519 -lowering effects were also maintained for at least 8 weeks after the completion of training. CONCLUSIONS: The equivalent magnitude of BP reduction between the 2 study groups suggests that repeated practice in BP self-regulation was more likely responsible for the efficacy of direct BP biofeedback training than was the type of feedback signals.

title: Effect of Feedback Signal on Blood Pressure Self-regulation Capability in Individuals With XXXX or Stage I @entity101 : A Randomized Controlled Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS']

entities_list: @entity1556 :: ('MESH:D058246', 'Disease') :: ['prehypertensive']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity13519 :: ('8991', 'Gene') :: ['systolic BP (SBP) and diastolic BP', 'SBP']

answer: @entity1556 :: (MESH:D058246,Disease) :: ['Prehypertension']


abstract: The individually different effects of exposure to comparable levels of chemicals might be partly explained by dissimilar response sensitivity towards chemicals. @entity18212 ( @entity18212 ) might be the clinical endpoint of this altered sensitivity. Concerning a subclinical range of chemical sensitivity, 'challenge studies' with @entity1 reporting chemical sensitivity are needed to improve the knowledge about such differences. The chemical and general environmental sensitivity questionnaire (CGES) is a standardized screening tool for the selection of this group. In the present study 24 healthy male volunteers, half of them classified as sMCS-subjects, were experimentally exposed to @entity11575 and @entity18008 at different levels (TLV-level vs. odor threshold). The strength of self-reported sensory irritations (nasal and ocular) and symptoms of bad smell were assessed, prior, during, and after the 4 hours of exposure. The time courses of sensory irritations were affected by sMCS. Across all exposure periods sMCS-subjects showed increasing symptom scores while control-subjects did not. Symptoms of bad smell were affected by three exposure-related factors (substance, level, duration) without any additional influence from the sMCS factor. Starting from these results it could be concluded that the time-depending influence of reported chemical sensitivity is most prominent for subjective data of sensory irritations.

title: Time courses of sensory irritations due to XXXX and @entity18008 exposure: influences of self-reported multiple chemical sensitivity (sMCS).

entities_list: @entity18212 :: ('MESH:D018777', 'Disease') :: ['Multiple chemical sensitivity', 'MCS']

entities_list: @entity18008 :: ('MESH:C004912', 'Chemical') :: ['ethyl benzene']

answer: @entity11575 :: (MESH:C005222,Chemical) :: ['2-butanone']


abstract: BACKGROUND _ AIMS: The liver is frequently challenged by toxins and reactive @entity26 species. Therefore, hepatocytes require cytoprotective strategies to cope with these insults. Since the transcription factors @entity10182 and NF-kB regulate the cellular antioxidant defense system and important survival pathways, we determined their individual and overlapping functions in the liver. METHODS: We generated @entity19 lacking @entity10182 and the NF-kB @entity1992 / @entity1992 subunit in hepatocytes and we analyzed their liver by using histopathology, immunohistochemistry, quantitative RT-PCR, Western blot and Oxyblot analysis. @entity1 @entity8055 ( @entity8055 ) were analyzed by immunohistochemistry. RESULTS: Loss of either @entity10182 or NF-kB/ @entity1992 had only a minor effect on liver homeostasis, but the double knockout @entity19 spontaneously developed @entity409 and @entity82 . Upon aging, more than one-third of the female double mutant @entity19 developed @entity5 , which histologically resemble @entity1 @entity8055 , a @entity5 that predominantly occurs in @entity1 . The @entity19 @entity5 also recapitulated the immunohistochemical marker profile characteristic for @entity1 @entity8055 . Moreover, pNRF2 and NF-kB @entity1992 / @entity1992 was not detectable in the nuclei of @entity8055 @entity5 cells. The @entity19 phenotype was not due to a synergistic effect of both transcription factors on cytoprotective @entity10182 target genes. Rather, loss of @entity10182 or NF-kB/ @entity1992 altered the expression of different genes, and the combination of these alterations likely affects liver homeostasis in the double mutant @entity19 . CONCLUSIONS: Our results provide genetic evidence for a functional cross-talk of @entity10182 and NF-kB/ @entity1992 in hepatocytes, which protects the liver from @entity39 , @entity32 and @entity82 . Furthermore, the double mutant @entity19 represent a valuable animal model for @entity8055 .

title: NF-kB/ XXXX and @entity10182 cooperate to maintain hepatocyte integrity and to prevent development of @entity8055 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'Human']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity8055 :: ('MESH:D018248', 'Disease') :: ['inflammatory hepatocellular adenomas', 'iHCA']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver inflammation']

answer: @entity1992 :: (19697(Tax:10090),Gene) :: ['RelA']


abstract: OBJECTIVE: To explore the clinical value of immature platelet fraction   @entity2416   , absolute immature platelet fraction    A- @entity2416    and thrombelastograph   @entity17792    on assessment of @entity548 risk of @entity3039   . METHODS: two hundred and seventy- one @entity1 with @entity3039 were assessed based on @entity3039 -BAT @entity548 grading system. @entity2416 , @entity2416 were determined in 271 @entity1 , @entity17792 in 125 @entity1 . The correlations between @entity548 grades and @entity2416 , @entity2416 , variables of @entity17792 in subgroups were analyzed by statistical method. The predictive value of @entity2416 , @entity2416 , and variables of @entity17792 on @entity548 risk of @entity3039 @entity1 was evaluated. RESULTS: There were no significant differences in @entity548 degree in all @entity1 with different gender and disease stage   P>0.05   . Mild @entity548 rate in @entity1 was higher than that in adult   P<0.05   . PLT inversely correlated with @entity548 grade for the entire cohort   P<0.001   . In all subjects, PLT< 30*10   /L and pediatric cohorts with PLT< 30*10   /L, PLT were negatively correlated with @entity2416   P<0.05   , positive correlated with @entity2416   P<0.001   and the maximum amplitude   @entity2704      P<0.05   . Bleeding grades were significantly correlated with @entity2416 , @entity2416 , @entity2704 in all subjects and @entity1 with PLT< 30*10   /L   P<0.001   . @entity2416 , @entity2416 and @entity2704 did not correlate with @entity548 grades in @entity1 with PLT< 30*10   /L   P>0.05   . ROC curve analysis revealed @entity2416 , @entity2416 and @entity2704 had better predictive value   AUC 0.745, 0.744, 0.813, P<0.001   . Multivariate analysis showed that @entity2416 and @entity2704 were independence factors for predicting @entity548 risk in @entity3039 @entity1 and comprehensive predictive value was higher   AUC 0.846, P<0.001   than single variable. CONCLUSION: @entity2416 , @entity2416 and @entity2704 could accurately evaluate @entity548 risk inITP @entity1 . It may be considered as reference index of the treatment and observation index of curative effect.

title: [Application of immature platelet fraction   absolute immature platelet fraction and thrombelastograph on assessment of XXXX risk in @entity1 with @entity3039 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity3039 :: ('MESH:D016553', 'Disease') :: ['immune thrombocytopenia    ITP', 'ITP']

answer: @entity548 :: (MESH:D006470,Disease) :: ['bleeding']


abstract: OBJECTIVE: To explore significance of preoperative @entity2996 ( @entity2996 ) for screening @entity1150 in @entity3140 . METHODS: From January 2009 to December 2011, 1200 @entity1 with @entity3140 caused by @entity130 were respectively analyzed. There were 833 males and 367 females,ranging from 20 to 78 (mean 41.94 +/- 15.41) years. All @entity1 had @entity4 and @entity158 in injured limbs when enrolled. @entity2996 was used to examine upper limbs vein at 3 to 10 d after improvement of @entity4 , 1 day before reduction. Relationship among occurrence of @entity715 , gender, age and @entity174 sites were analyzed. @entity1 with @entity11942 were analyzed with respective study to decide whether combined with @entity6 , @entity101 and @entity407 . RESULTS: All @entity1 were checked by @entity2996 ,which confirmed 9 cases with @entity11942 . The rate of @entity715 was 0.75%, @entity1 than @entity1 (P < 0.01). The risk of @entity4461 occurred over 30 years, and the occurrence of @entity715 in humerus @entity174 was higher than radius ulnar @entity174 . One of 9 @entity1 combined with @entity101 and @entity407 , 1 case combined with @entity6 , and 7 cases with no complication. CONCLUSION: Upper @entity174 may occur @entity1150 ; @entity2996 should be used to check @entity11942 in qualified hospital,which can maintain medical safety,decrease occurrence of medical disputes, and ganrantee @entity1 's safety.

title: [Significance of preoperative color doppler flow imaging for screening XXXX in @entity3140 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'patient', 'women', 'Patients', 'patients']

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['trauma fracture', 'fracture']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity2996 :: ('MESH:C564543', 'Disease') :: ['color Doppler flow imaging', 'CDFI']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity3140 :: ('MESH:D038062', 'Disease') :: ['upper limb fracture', 'upper limbs fracture']

entities_list: @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clots']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']


abstract: BACKGROUND: We aimed to comprehensively evaluate lipoprotein profile including lipid particle size following a lifestyle intervention in @entity209 ( @entity209 ) volunteers and to assess the associations between lipoprotein subfractions and @entity1004 ( @entity1004 ) - a surrogate indicator of @entity731 . METHODS: 100 @entity1 (50-70 years) from the RESOLVE trial, underwent a one-year follow-up beginning with a three-week residential program combining high exercise volume (15-20 h/week), restrictive diet (-500 kcal/day), and education. For baseline references, 40 aged-matched healthy controls were recruited. Independent associations between subfractions of lipoproteins and @entity1004 were evaluated using a generalized estimating equations model accounting for variation in correlations between repeated measures. The lipoprotein subfractions profile was assessed using Lipoprint   electrophoresis allowing to separate: the very low-density lipoprotein (VLDL) fraction, then the intermediate-density lipoprotein (IDL) C, B and A, the low-density lipoprotein (LDL) with subfractions 1 and 2 as large LDL and subfractions 3 to 7 as small dense LDL (sdLDL), and the high density lipoprotein (HDL) subfractions categorized into large, intermediate, and small HDL. Apolipoproteins A1 and B were also measured. RESULTS: 78 @entity1 completed the program. At baseline, apolipoproteins B/A1, VLDL, sdLDL and small HDL were higher in @entity209 than in healthy controls; IDL, LDL size, large and intermediate HDL were lower. Despite time-related regains during the follow-up, lipoprotein subfractions traditionally involved in cardiovascular risk, such as sdLDL, improved immediately after the residential program with values closest to those of healthy controls. @entity1004 improved throughout the lifestyle intervention. Using a generalized estimating equations model, none of the subfractions of lipoproteins nor apolipoproteins were linked to @entity1004 . CONCLUSIONS: Lipoprotein subfractions traditionally involved in CVR, decreased after the 3-week residential program. During a 12 month follow-up, the time-related regains remained closer to the values of healthy controls than they were at baseline. @entity1004 improved throughout the lifestyle intervention. However, we failed to demonstrate a link between some lipoprotein subfractions and the atherogenicity directly measured from the wall thickness of arteries ( @entity1004 ). Further investigations are required to explore the atherogenicity of lipoprotein subfractions. TRIAL REGISTRATION: NCT00917917.

title: Atherogenic subfractions of lipoproteins in the treatment of XXXX by physical activity and diet - the RESOLVE trial.

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'MetS']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherogenesis']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1004 :: ('MESH:C563733', 'Disease') :: ['carotid-intima-media-thickness', 'CIMT']

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']


abstract: OBJECTIVE: The aim of this study was to compare the three different treatment methods and investigate The effectiveness of the therapeutic effect of common salt. METHODS: This retrospective study involved @entity1 who were treated in our clinic for umbilical @entity2869 between January 2010 and December 2011. The @entity1 were divided to three subgroups according to treatment methods. Group I: Cases treated with only local debridement and systemic antibiotic, group II: cases treated with local debridement, systemic antibiotic and @entity7292 , group 3: cases treated with debridement, systemic antibiotic and salt. RESULTS: In this study, 63 @entity1 with the diagnosis of @entity6052 were treated in our clinic. The @entity1 were classified into three groups; group I included 20 @entity1 , group II included 18 @entity1 and group III included 18 @entity1 . During 16-24 months of follow-up, 4 (20%) recurrences in group1 and 2 (11.1%) recurrences in group 2 were detected. Recurrence rate of group 3 was significantly different (5.55%) when compared to group 2. The mean period for returning to daily activities and work was 1 day for the @entity1 . CONCLUSION: In conclusion, we suggest that @entity2869 cases which are not complicated by abcess and cellulitis can be treated by local removal of umbilical hairs, debridement and dressing without surgery. We conclude that application of common salt (table/ cooking salt) to umbilical @entity2869 with @entity738 is a simple and highly effective way of treatment without any relapse and complications. KEY WORDS: Conservative treatment, Local debridement, Umblical @entity2869 .

title: Effective conservative treatment of umbilical XXXX : @entity7292 ? Salt?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma']

entities_list: @entity7292 :: ('MESH:D012835', 'Chemical') :: ['silver nitrate']

entities_list: @entity2869 :: ('MESH:D010864', 'Disease') :: ['pilonidal sinus', 'pilonidal sinus disease']

answer: @entity2869 :: (MESH:D010864,Disease) :: ['pilonidal sinus disease']


abstract: Inhaled @entity1483 has been shown to protect subjects with @entity565 from bronchoconstriction induced by a wide variety of stimuli, including allergen, but the mechanism of action is controversial. We have used an in vitro model of allergen-induced bronchoconstriction to examine the effects of @entity1483 and other ion transport inhibitors. @entity1 bronchial rings were passively sensitized by incubation with serum from an atopic donor and were challenged with @entity7130 . Allergen-challenged bronchial rings developed bronchoconstriction which was effectively inhibited by the @entity26510 antagonist @entity30207 (10(-7) M) and to a lesser extent by @entity9691 (10(-5) M). Assessed over 60 min @entity1483 10(-6), 10(-5), and 10(-4) M inhibited contractions by a mean (95% confidence interval [CI]) 7.9% (-23.5, 39.3%, p > 0.05), 44.2% (12.9, 75.2%, p < 0.01), and 86.9% (55.5, 118.3%, p < 0.001) respectively (n = 5). The same concentrations of @entity11623 inhibited contractions by 21.5% (-8.4, 51.4%, p > 0.05), 13.6% (-16.3, 43.4%, p > 0.05) and 51.6% (21.7, 81.4%, p < 0.01) respectively (n = 5). The @entity1372 transport inhibitor @entity6478 and the anion transport inhibitor @entity18850 ( @entity18850 ) were without effect (both 10(-4) M; n = 4). @entity1483 increased @entity1421 production by the bronchial rings by 134% (95% CI 53, 259%). @entity3352 (3 x 10(-6) M) blocked the @entity1483 -induced increase in @entity1421 production and reduced the protection afforded by 10(-4) M @entity1483 against allergen-induced contractions from 67.9% to 34.7% (mean difference 33.2%; 95% CI 9.7, 56.6%; p < 0.01; n = 8).(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of diuretics on allergen-induced contractions of passively sensitized XXXX bronchi in vitro.

entities_list: @entity7130 :: ('6956', 'Species') :: ['Dermatophagoides pteronyssinus']

entities_list: @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide', 'Furosemide']

entities_list: @entity6478 :: ('MESH:D000584', 'Chemical') :: ['amiloride']

entities_list: @entity18850 :: ('MESH:D017878', 'Chemical') :: ["4,4'-diisothiocyanostilbene-2,2'-disulfonic acid", 'DIDS']

entities_list: @entity9691 :: ('MESH:D016593', 'Chemical') :: ['terfenadine']

entities_list: @entity11623 :: ('MESH:D002034', 'Chemical') :: ['bumetanide']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin']

entities_list: @entity26510 :: ('MESH:C112381', 'Chemical') :: ['cysteinyl-leukotriene']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Recent research has addressed the hypothesis that religiosity/spirituality and sense of coherence buffer the negative effects of stress on numerous health issues. The aim of the current study was to further this work by exploring potential links between psycho-social factors such as religiosity/spirituality and sense of coherence with @entity308 . METHODS: A total number of 220 subjects of the SPILI III cohort (1988-2012) attending a primary care setting in the town of Spili on rural Crete represented the target group. All @entity1 underwent a standardized procedure. Validated questionnaires were used to evaluate sense of coherence, @entity308 levels and religious and spiritual beliefs. A multiple linear regression analysis of the Beck Depression Inventory Scale (BDI) in relation to demographic characteristics, scores on the Royal Free Interview for Spiritual and Religious Beliefs scale (RFI-SRB) and Sense of Coherence scale (SOC) was performed. RESULTS: A significant inverse association was found between BDI and RFI-SRB scale (B-coef =   -0.6999, p < 0.001), as well as among BDI and SOC scale (B-coef =   -0.556, p < 0.001). CONCLUSIONS: The findings of the current observational study indicate that highly religious @entity1 are less likely to score high in the @entity308 scale. Furthermore, @entity1 with high SOC scored significantly lower in the BDI scale. Further research is required in order to explore the potential effect of SOC and religiosity/spirituality on mental health.

title: Effect of religiosity/spirituality and sense of coherence on XXXX within a rural population in Greece: the Spili III project.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: PURPOSE: Most @entity5 susceptibility genes are @entity5 suppressor genes that are biallelically inactivated in familial @entity5 through somatic deletion of the wild-type allele. Identifying the genomic losses that occur in @entity788 , particularly those that occur in @entity5 , may help localize the genes responsible for @entity788 susceptibility. EXPERIMENTAL DESIGN: Normal and neoplastic tissue DNA was isolated from fresh-frozen surgically resected tissues from 20 @entity1 with primary @entity788 (defined as having at least one first-degree relative with @entity788 ), 31 with @entity70768 ( @entity4929 ), and 7 with familial IPMNs using laser capture microdissection. Microdissected DNA was whole genome amplified using multiple strand displacement. Genome-wide allelotypes were determined using 391 microsatellite markers. The accuracy of microdissection and fidelity of the whole genome amplification were determined by comparing the genotypes of microdissected primary @entity788 to the genotypes of xenografts derived from these @entity5 and by comparing the results of amplified to nonamplified specimens. RESULTS: The concordance of genotypes between LCM whole genome amplified primary @entity788 and their corresponding @entity788 xenograft DNAs was 98%. Among the 20 primary familial pancreatic @entity420 , we found a high prevalence of loss of heterozygosity (LOH) with an average fractional allelic loss (FAL) of 49.9% of an aggregate of 2,378 informative markers. The level of FAL in the IPMNs (10%) was significantly lower than in the pancreatic @entity420 . The most common locus of LOH in the IPMNs was at 19p (LOH at 24% of markers). The regions of frequent allelic loss observed in the @entity788 were similar to those found in sporadic @entity788 . CONCLUSIONS: The allelic loss patterns of @entity5 and IPMNs provide clues as to the genomic locations of @entity5 suppressor genes inactivated in these @entity5 .

title: Genome-wide allelotypes of familial pancreatic @entity420 and familial and XXXX .

entities_list: @entity70768 :: ('MESH:C538614', 'Disease') :: ['sporadic intraductal papillary mucinous neoplasms']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['familial pancreatic cancers', 'pancreatic cancers', 'familial pancreatic adenocarcinoma', 'pancreatic neoplasms', 'pancreatic cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'familial and sporadic pancreatic cancers', 'cancers', 'familial cancer', 'neoplasms', 'familial and precursor neoplasms']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity70768 :: (MESH:C538614,Disease) :: ['sporadic intraductal papillary mucinous neoplasms']


abstract: Overcoming resistance to chemotherapy is an important goal in @entity5 treatment. In many systems, resistance to @entity8253 and @entity17074 correlates with a diminished intracellular content of drug. In @entity23198 and @entity8270 , an active outward transport of @entity8253 and vinca alkaloids occurs. @entity460 channel blockers, such as @entity1855 , inhibit this active outward transport and increase intracellular content of @entity5713 and @entity8253 in cells resistant to vinca alkaloids and @entity8253 , respectively. We report a phase I trial of @entity5713 (1.5 mg/m2 daily as iv continuous infusion X 5 days) in 17 @entity1 and concurrent @entity1855 in escalating doses. @entity1855 was administered as a loading dose (0.02-0.1 mg/kg) followed by a maintenance infusion (0.036-0.18 mg/kg/hour) for 5 1/2 days with continuous cardiac monitoring. There was no apparent augmentation of @entity5713 @entity137 when @entity5713 and @entity1855 were given concurrently. ECG change was the dose-limiting @entity137 . At 0.12 mg/kg/hour, five of nine @entity1 developed first-degree @entity616 (mean P-R interval, 0.32 seconds; range, 0.23-0.52 seconds). Junctional rhythms were noted in two of 17 @entity1 . Reversible nonspecific T-wave changes were seen in four of 17 @entity1 . Blood pressure and left ventricular ejection fractions (ultrasonic) were not altered. Five of 17 @entity1 had wbc count nadirs less than 2000/mm3, and two of 17 @entity1 had platelet count nadirs less than 100,000/mm3. Four @entity1 experienced @entity2359 . A mean @entity5713 concentration of 2.2 ng/ml (0.55 nM) and a mean @entity1855 concentration of 290 ng/ml (0.45 microM) were achieved with the concurrent 5-day infusion. The tolerable levels of @entity1855 obtained appear to be less than those which were reported to inhibit @entity5713 efflux in vitro. Additional in vitro experiments at the tolerable doses of @entity5713 and @entity1855 are recommended.

title: Phase I study of XXXX and @entity1855 given by concurrent iv infusion.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity8253 :: ('MESH:D018943', 'Chemical') :: ['anthracyclines']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity17074 :: ('MESH:D014748', 'Chemical') :: ['vinca alkaloids']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil', 'Verapamil']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['heart block']

entities_list: @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['Calcium']

entities_list: @entity8270 :: ('MESH:D002286', 'Disease') :: ['Ehrlich ascites tumor']

answer: @entity5713 :: (MESH:D014747,Chemical) :: ['vinblastine']


abstract: UNASSIGNED: Background and study aims: The clinical utility of computed virtual chromoendoscopy with flexible spectral imaging color enhancement (FICE) in capsule endoscopy (CE) remains controversial. To clarify the clinical utility of FICE-enhanced CE in evaluating @entity29 , we quantitatively assessed white light (WL), FICE, and blue mode (BM) images and examined the sensitivity of these 3 imaging modes of small-bowel lesions from @entity1 who underwent CE. Methods: The CIELAB color difference (   E) and visual analogue scales (VAS) were measured in 261CE images (3 different lesion categories) using WL and FICE set 1, 2, and 3, and BM images, respectively. Three endoscopists reviewed CE videos with WL, 3 FICE mode settings, and BM, and compared the sensitivity and detectability for small intestinal diseases from 50 @entity1 who underwent CE. Results: In the assessment of visibility in the 152 vascular lesion images, the    E and VAS of FICE set 1, 2, and BM images were significantly higher than that of WL images. In 88 @entity2681 /ulceration images, the    E and VAS of FICE set 1 and 2 images were significantly higher than that of WL images. In 21 @entity5 images, there were no significant differences in    E among these modalities. When analyzed on a per- @entity1 basis, FICE settings 1 and 2 had the highest sensitivity (100%) and specificity (97.3-100%) for @entity455 . As for erosive/ulcerative lesions, FICE setting 2 had the highest sensitivity (100%) and specificity (97.2%). For @entity5 or @entity1127 , WL had the highest sensitivity (90.9%) and specificity (87.1%). In per-lesion analysis, FICE settings 1 and 2 showed significantly superior detection ability over WL for @entity455 . In the detection of erosive/ulcerative lesions, FICE setting 2 was significantly superior to WL. In @entity5 images, there was no significant improvement with any of the settings relative to WL images. Conclusions: FICE is most useful for improving CE image quality and detection in cases of angioectasia and @entity2681 /ulceration of the small intestine.

title: Clinical utility of capsule endoscopy with flexible spectral imaging color enhancement for diagnosis of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['small bowel lesions']

answer: @entity29 :: (MESH:D015212,Disease) :: ['small bowel lesions']


abstract: INTRODUCTION: @entity130 @entity572 dislocations in @entity1 and adolescents require prompt concentric reduction. Incomplete reduction with or without retained osteochondral fragments has traditionally been addressed with open reduction. We report on the use of arthroscopy to remove loose bodies and reduce enfolded soft tissues to obtain concentric reduction in the pediatric and adolescent population. Specific note is made of underlying pathology and arthroscopic intervention. METHODS: After obtaining Institutional Review Board approval, we performed a retrospective review of @entity1 under the age of 19 who were treated with @entity572 arthroscopy following @entity572 reduction at a single @entity1 's hospital from 2006 to 2013. Clinic notes, operative reports, radiographic images, and arthroscopic photographs were reviewed. RESULTS: Seven @entity1 were identified (aged 8 to 17) who underwent @entity572 arthroscopy after a @entity572 . Intra-articular bone fragments were found in 6 of 7 @entity1 and 5 of 7 @entity1 had an incongruent @entity572 joint identified by imaging before surgery. The predominant pathology was @entity155 of a small bony fragment attached to the posterior capsular labral soft-tissue complex, which became enfolded and blocked reduction (5 of 7 @entity1 ). In all cases, the enfolded soft tissue was reduced without soft tissue or bone repair. @entity4713 were removed, and in 2 cases an avulsed ligamentum teres was debrided. Average follow-up was 10 months. No @entity2530 or recurrent instability was identified in any case. CONCLUSIONS: When incongruent @entity572 were arthroscopically evaluated after @entity130 , a consistent pattern of interposition of avulsed posterior bone fragment with attached capsule and labrum was found. Reduction of the capsulolabral complex without repair provided satisfactory short-term outcomes. Arthroscopic treatment of such cases was effective and well tolerated and could lead to considerably less postoperative @entity158 and surgical morbidity than open surgical treatment. LEVEL OF EVIDENCE: Level IV-case series.

title: Arthroscopic Treatment of XXXX Hip Dislocations in @entity1 and Adolescents: A Preliminary Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity4713 :: ('MESH:D010007', 'Disease') :: ['Additional loose osteochondral fragments']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip dislocation', 'hip joints', 'hip', 'posterior hip dislocation']

entities_list: @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsion']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Traumatic', 'traumatic dislocation']

entities_list: @entity2530 :: ('MESH:D010020', 'Disease') :: ['avascular necrosis']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Traumatic']


abstract: OBJECTIVE: To examine interactions between demographic, @entity158 , urinary, psychological and environmental predictors of quality of life (QOL) in @entity1 with chronic @entity1069 /chronic @entity2371 ( @entity2723 /CPPS). @entity1 AND METHODS: In all, 253 @entity1 previously enrolled in the National Institutes of Health @entity1069 Cohort study in North American tertiary-care clinical centres (six in the USA and one in Canada) self-reported with validated instruments, including the QOL subscales of the Short Form-12 (physical, SF12-PCS; and mental, SF12-MCS), demographics, urinary symptoms, @entity308 , current @entity158 , @entity158 coping, 'catastrophizing' (catastrophic thinking about @entity158 ), @entity158 control, social support and solicitous responses from a partner. Data were collected through a one-time survey. Covariates determined to be significant were entered into a multivariable regression model predicting SF12-PCS and SF12-MCS. RESULTS: Adjusting for covariates, regression models showed that poorer SF12-PCS scores were predicted by worse urinary function (P < 0.001) and increased use of @entity158 -contingent resting as a coping strategy (P = 0.026). Further, poorer SF12-MCS scores were predicted by greater @entity158 catastrophizing (P = 0.002) and lower perceptions of social support (P< 0.001). In separate follow-up analyses, helplessness was the significant catastrophizing subscale (P < 0.001), while support from family and friends were the significant social support subscales (P = 0.002 and <0.001). CONCLUSIONS: These data suggest that specific coping and environmental factors (i.e. catastrophizing, @entity158 -contingent resting, social support) are significant in understanding how @entity1 with @entity2723 /CPPS adjust. These data can be used to develop specific cognitive-behavioural programmes for @entity1 with @entity2723 /CPPS who are refractory to standard medical therapy.

title: Psychosocial variables affect the quality of life of XXXX diagnosed with chronic @entity1069 /chronic @entity2371 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS', 'men']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['Chronic Prostatitis', 'prostatitis']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain syndrome']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: INTRODUCTION: @entity11252 ( @entity11252 ) is a type of @entity9 where @entity1746 symptoms persist despite structurally corrective spinal surgery. This implies more @entity16 rather than simply dysfunction whereby correcting the inciting structural derangement does not provide for clinical resolution. What remains unclear is how to predict which @entity1 are likely to derive benefit from surgical intervention, and whether specific @entity158 characteristics are associated with different likelihoods of good outcome. METHODS: This study analyzed a prospective data set of @entity1 managed surgically for painful @entity614 secondary to lumbar @entity179 by the senior author at Toronto Western Hospital neurosurgery over the past 24 months. Clinical parameters include general demographics, preoperative and postoperative clinical examination, surgical details, general self-reported @entity158 and disability scores, and @entity9 scores. The screening tests used in this study were Douleur Neuropathique 4 (DN4) and Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), correlation tested by the Spearman coefficient. Multiple logistic regression analysis was used to define predictors of persistent postoperative symptomatology. RESULTS: Among 250 @entity1 treated for @entity614 , 12% exhibited @entity11252 with modest relief of leg @entity158 compared with the cohort of @entity1 in whom substantial improvement was seen. The postoperative condition was associated with abnormal preoperative screens for @entity9 , but not sex, smoking status, or preoperative @entity158 severity. Good correlation was seen between the 2 screening tests used in this study for both absolute ordinal score and thresholding as @entity9 (Spearman, P < .001). CONCLUSION: While @entity11252 was more common among younger and female @entity1 , this occurred with low overall frequency. Higher @entity9 screening scores correlated strongly with the likelihood and severity of significant postoperative leg @entity158 . Further work is required to develop more accurate prognostication tools for @entity1 undergoing structural spinal surgery for @entity614 .

title: 184   Use of @entity9 Questionnaires in Predicting the Development of @entity11252 Following Lumbar Discectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['substantial nerve damage']

entities_list: @entity1746 :: ('MESH:D020335', 'Disease') :: ['extremity']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative spondylosis']

entities_list: @entity11252 :: ('MESH:D055111', 'Disease') :: ['FBSS', 'Failed back surgery syndrome']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['lumbar radiculopathy', 'radiculopathy']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

answer: @entity614 :: (MESH:D011843,Disease) :: ['Radiculopathy']


abstract: OBJECTIVE: To determine the psychological wellbeing of sole mothers in Australia. DESIGN: Cross-sectional analyses of survey data from The Australian Longitudinal Study on @entity1 's Health. @entity1 : 9689 younger @entity1 (aged 22-27 years) surveyed in 2000 and 12 338 mid-age @entity1 (aged 47-52 years) surveyed in 1998. MAIN OUTCOME MEASURES: Demographic characteristics and economic status; prevalence of suicidal thoughts, self-harm, and psychoactive medication use; @entity308 (Center for Epidemiologic Studies Depression Scale) and @entity458 (the Mental Health Component Score of the Medical Outcome Short Form Health Survey [SF-36]). RESULTS: Among the younger @entity1 , sole mothers were more likely than other @entity1 to have experienced suicidal thoughts (odds ratio [OR], 2.18; 95% CI, 1.45-3.27) and self-harm (OR, 3.25; 95% CI, 1.97-5.38). Among the younger and mid-age @entity1 , sole mothers were the group most likely to have used medication for @entity308 (ORs, 2.75 [95% CI, 1.76-4.30] and 2.29 [95% CI, 1.56-3.37], respectively). They were more than twice as likely to have experienced @entity308 , and had significantly poorer @entity458 (P < 0.001). After adjusting for economic status, only @entity308 and @entity458 remained significantly associated with sole motherhood, and the strength of these relationships was reduced. CONCLUSIONS: Economic status partly accounts for the relatively poorer @entity458 of sole mothers. Sole mothers are more likely than other @entity1 to experience debilitating @entity458 .

title: The XXXX of sole mothers in Australia.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'PARTICIPANTS']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological health problems', 'psychological health']

answer: @entity458 :: (MESH:D020018,Disease) :: ['psychological health']


abstract: BACKGROUND: This prospective study was undertaken to assess @entity137 , resectability, and survival in @entity788 @entity1 presenting with locally advanced, unresectable disease treated with neoadjuvant @entity136 , @entity1205 , and @entity416 (GTX) and @entity136 and @entity416 (GX)/radiation therapy ( @entity1161 ). METHODS: All @entity1 presenting to the Pancreas Center were evaluated for eligibility. Forty-five @entity1 (mean age, 64 years; range, 44-83 years)-34 @entity1 deemed unresectable because of arterial involvement and 11 @entity1 deemed unresectable because of extensive venous involvement-were treated with 6 cycles of GTX. Those with arterial involvement were treated with GX/ @entity1161 after chemotherapy. RESULTS: The GTX and GX/ @entity1161 treatments were tolerated with the expected drug-related @entity137 . There were no bowel perforations, cases of @entity788 , or delayed strictures. Among those with arterial involvement, 29 underwent subsequent resection, with 20 (69%) achieving R0 resections. All 11 @entity1 with venous-only involvement underwent resection, with 8 achieving R0 resections and 3 achieving complete pathologic responses. For the arterial arm, the 1-year survival rate was 71% (24 of 34 @entity1 ), and the median survival was 29 months (95% confidence interval, 21-38 months). Thirteen @entity1 (38%) have not relapsed (range, 5-49+ months). For the venous arm, the median survival has not been reached at more than 42 months. Six @entity1 (55%) in the venous arm did not experience recurrence (range, 6.2-42+ months). CONCLUSIONS: GTX plus GX/ @entity1161 is an effective neoadjuvant regimen that can be safely administered to @entity1 up to at least the age of 83 years. It is associated with a high response rate, a high rate of R0 resections, and prolonged overall survival. @entity5 2014.    2014 American @entity5 Society.

title: Neoadjuvant @entity136 , @entity1205 , and @entity416 followed by @entity136 and @entity416 @entity1161 and surgery in locally advanced, unresectable XXXX .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic adenocarcinoma']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']


abstract: @entity1358 ( @entity1358 ) is one @entity1 @entity5 to which the immune response may control the growth of @entity5 cells. These @entity5 are infiltrated by a large mononuclear infiltrate mainly composed of T lymphocytes. To characterize the lymphocytes infiltrating @entity1358 , we analyzed the molecular structure of the T cell receptor (TCR) alpha and beta chains in @entity5 and paired peripheral blood lymphocytes from a series of 6 untreated @entity1 . We first determined V alpha and V beta gene segment usage by PCR using a panel of V specific oligonucleotide primers (V alpha 1-w29 and V beta 1-w24). A highly diverse usage of TCR V alpha and V beta gene usage was observed in 5 of 6 @entity5 . In addition, the few @entity5 overexpressed V beta specificities detected by reverse transcription-PCR were shown to contain minor T cell expansions. Strikingly, 1 of the 6 @entity5 studied displayed a skewed TCR repertoire with V beta 4 transcript representing 25% of the TCR signals. @entity5 overexpressed V beta transcripts was analyzed by @entity2612 size distribution analysis. In the particular @entity5 displaying a biased repertoire large expansions of T cell subpopulations were detected (particularly in V beta 4) specifically at the @entity5 site. Such T cells may be expanded locally in response to @entity5 antigens.

title: In vivo local expansion of clonal T cell subpopulations in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['Renal cell carcinoma', 'RCC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Clonality of the tumor', 'tumor', 'tumors']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']